ENSGT00530000063078 : Linker Region Query Results

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-----------------------MDIKEESLLPY-YTAQSG--AEVGMFNGLFDSATGKL
QQQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------R-YGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAP-F-DELLGH-------GQST-NSTKGKKR--KAGKTLEL---TRLLPL-----
KFVR-ISVHKRD--------EQQLRLKFATGRSCY-------LQLCPP---PESKDDLFS
YWEKLIDLLRPPVDSNTST---HAIP----AGDMM--STPFLDEELKIP-------KKKG
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----------KRKSGH------------RKKRD---LYKV-SVKS---LP-A-TTDVSAI
SSS-AF---------SGGEET-HDSHISTIVSRIPTPKVSSKVLA-RE-SA---------
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-------------------------------------SEAIV--CDLVDSLS-LAAN---
--M-PEGLG-QINK-ATVGE-------------------------AAL-GARGSKSHLTI
ASD-------GKM-SPKSMKIALAGMASKSLEYI---P--SSPASLSRKE-IMTVTNSRI
ET-TG----ETAN--DPVP------------VVLALTLPSESHSSEETG-RRKAYETNTK
AHK------ERRSR--RDQRAKERVGSR-SEQHQRTG---------------------EG
H-KTEGDKEFQKSTSHR-GVG-----D--------------------DKK--------DK
-GSKRN-RWHKGVSHVPITKESRN-----SHKLSRTISTASSA-----STSK--------
-RMGRISLFLRNIRANLAGKSLA---------P-RGQ---DVGIMTKTLE-TTDVKAIME
A-EDGQGLE-II-DSVTSEV-------------METVTFEAH------------------
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-------------------------MKKNKG--K-SV---------------DTRGPGHL
QNMLDEG-EYA-PFLS-----APMLES------NFI--Q---------------------
-VN------------R-RGESIYVHNRANWVTVGICSSSSTQ----KTPNV--------M
LLAHLKPTTQKH-----------EAQL---FENLLAS-P-TEKLVL---TRFLPL-----
QFVT-LSVHDAK--------SMRLKVKLVSGRAYY-------LQLCVP---ANKQDALFS
QWMDLISLLNEKKAKTS--KVSEVSS-LSEITNST--EVTSSMDIMDIT-----AFTNAQ
ATHMYL---PVHVTESMNFSEFTDATDI---TDVTDIPENEV-TE---FPDIK-------
---------I-----V---------TEVTEVIE---ATEV-------KSI-SDATNSPGV
TVVFENDDIIR--AKQEEKEKRDSVVKTSCLRDAR-SKHEFKQ-----------------
---------SS--------------------------------------------K----
--------------------HVTISD-ITLTFEGERCFQTPLTPLKSEADLC---G----
--ELT-EATSEEKKTGFKNTALKSLEARSLRADSDTS---GLNTFSVLPL----ISISFP
HFTLL-------------------------------------------------------
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-----------------------------------------------M------------
---------------GSS---GLAGE--------------R--RTQARR----GCTWCRN
QRG--------------------LTSD------LWP--Q---------------------
-VT------------R-FGE------VANTVTMGVAASSPAL----ELPDL--------L
LLAGPTKENG----------------------------C----QEL---LGLFPL-----
QFVE-LFVHDES--------RQQLKVKFCTGRAFY-------LQLRAP---AETRHLEFG
QWVR--------------------------LLYRL--RYH-----------------AGQ
GAVPFTQEES-------EDE---GWDEE---TIEDPE-------------TKE-------
--------------------G-----------ETLLPTQL--QAR---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
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-------------------------VSSESMLPY-YTAASG--RAVGMFN----TSMGEL
QKQLYKG-EYD-AFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVGIVSTSPILPL----PNV--------M
LLARPVSYI-DNQSTL-------EGSSYKRKMRPSP--HPSNTLEL---TRLLPL-----
KFVK-ISVHDRE--------KQQLRLKLASGRSFY-------LQLCPP---SDAREDLFS
YWEKLIYLLRPPIEGYSST---HAIP----AGDGL--EAPVFMAEDKSP-------SQE-
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------------PIIL------------HSEGE---QDKV-SIKS---LH-MG-PE----
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-------------------------MNKIRGLPPAV-RDPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGHWMDAYERSATVILGVTSSVPSLPL----PNV--------L
LMANLTWPHGP-------------------LSTSSN--PGAPVITL---SRILPL-----
KYVE-LQIYDRT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKIPSSSIET--TP-ECSLPSSSQ
ASETI--MLLAAERASGSLLGLSE------------------------------------
--------------RYKL----------------------TGDRHND-------AATVTD
KPK---------------------RCKTPPLMASS--------------INMPMRATLTH
SLWEQEDPN-ENFL-----------------QVPVASSLG--------------------
----------------------------------ENFLGP--------------------
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------------------------------MKRGYDP-------KPAL------------
---------------GGAGEEGTCEMGH-------GRQKRP--LFPAYP----KGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHDEC--------RRQLKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--HFH-----------------SAE
GAVPFTQEYA-------LED---DGEEE---DDDDDD--------D--------------
-------------------------------------DEE--SRM---------------
------------EVRLDPQ---------------------------------------AS
ELWGL-------------------------------------------------------
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-----------------------MTANSECLLPY-YTAQSG--SGVGMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAAGH-EGLA--------------GRTKGKGR--KSSKTLEL---TRLLPL-----
KFVR-ISVHDRD--------KQQLRLKFATGRSCY-------LQLCPP---LDAREDLFA
YWEKLIYLLRPPVDSNSST---YAIP----AEEMI--CMPAFEEEDKTS-------L-G-
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------------AGDL------------HAKGD---QDQV-SIRS---LH-MV-SEVCGA
TSA-AY---------VGGEGIQHGSHKSTSKTNIAIPRTKSKEHV-K--ESAT-------
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---------------E-GAAGSGQAG---------GDK-ADA-------------TL---
--T-GARGS-KTHV-ATAGS-------------------------AKG------------
--------------SPKSLKVGLAANKPLEGIPS---T---SS-SFSPEG-AGNIGVEPA
-------AGKTAG--EPDKNSAAGSFTPTR-------LSDKGGQAKRQQ-SSHIR---TE
VHK------ERRER--RERREKDRTVSRST--HHRRG---------------------EG
RH-KTGDKISRKSTG------RRTVRE--------------------DK---KG--KS--
--SKHS-STHKGISRSPITKESRS-----SHKSGRSLSTTSSG-----SANK--------
-RMGRIGSFLKTVKANLTTKGVA---------SVRGR---DMDVTAKREE-RTTMEAIME
TAESGQGLD-LT-GSVTSEV-------------METMTFETH------------------
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------------------------------------------------------LT----
-------------------------VQCTRP--L-FHAKSH--QIHRICIPI----MGDL
QKALERG-EYI-PLR------APVFES------NFI--Q---------------------
-VN------------K-RGESIYLHNRPNYVTMGICASSPEL----HLPNV--------M
LLAHSTPPSSQENI--------STRPA---RSKHVG---SEDKLVL---TRYLSL-----
KLVD-LSVHSVE--------ERRLKLRLVNGCAYY-------LALCAP---PEKQTRLFH
QWMQLIDRLK--------------------------------------------------
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-------------------------------------MSSVPHGKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDQEPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETNKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
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-------------------------MEDRCMLPYYYTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DLI--Q---------------------
-IS------------K-RGEVIDVHNRA-MVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKRDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGNTL--DSSVFEEVQRSP-------VG--
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------------YDTK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
AYY-DY---------IIEI-----------------------------------------
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-------------------------------------MSSVTHRNT-WWKLK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEQN--PGVGL-----GVEEGLL
CQKVRSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWIDIYKASNTMALGVTSSVPCLPL----PNV--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIIL---KRILPL-----
KFVE-LQVCDRL--------QRILRLRTVTEKIYY-------LKLHPN-----HPATVFH
FWIRLVQILQKGLSITTKD---PKIL----VTHCLVPKNCCSPSGD-SKL-VQKKPQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQFRSSKKMETNK--D-SS---E
-R-Y--------------------SGKTSNEDSIP--CT----------RDLCWRDSFTY
GEWERENPS-GPQP--------------LSLLSTLAASTRPH------------------
----------------------------IYVPTKELF-R---------------------
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------------------------------MKGSRE----------HLLTGYM-------
-------------------------EEA--GLNY-G----------VML----GVEGGAL
YQLLRTP-EYN-LFTE----S-AMFES------DFV--Q---------------------
-VT------------S-RGALLDIHNISSRVTLGVTSSVPSL----PLPNV--------L
LIARFTIP-H----------------------------HGSPHKEL---TKLFPL-----
KLVR-LTVHKKE--------LRLLKLLLANHRSYY-------LQLQHK---H--PDIVFQ
LWIRLVHILHSGLSITFKD---SRIA----LPKQF--DFI-----------------NP-
---------------------------S---SSESSLYEHDI-WEMDTELHST-------
-------------ADRKQKGGK---RSTQQPRLLLEG-TVSNQRSEKAES-PSEESNSAK
SDQAEWNNVNGSSLHECEL------CVQLPPDSPK-EKKE--------------------
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RPRAPSREGDLSYGLWERDTP-----AGMMPLSRLSSLIAVGHSLAPRDW-RMFLQK---
--------VQRQK-----------------------------------------------
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-------------------------MNR--FRNI-RCLRLF--HSPPKW----VPTLGQL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGGPVYLHHRTNRLTMGVAASLPGL----VLPDI--------L
LLARPPE--G----------------------------EESSRLDL---TRMIPL-----
DLAH-LYVHDLA--------TWRLKLRLVTGRYYY-------LELDAP---DEELGFLFD
RWIRLIDLLRQPARAWAPR---TLHS----P--PL--ELR-----------------LS-
------------------------------------APPAST-WRLQEAGRSK---GPEH
GCQGHFLYMT--VTPQRQRKAK-----------SLKRNRVKSQAV-------------GD
SEPLLWSQLELASVRKKSKHRHEKCRPGRALDRGQ-TEIQVSGD----------------
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-------------------------------------------SEEPSLVIR---T----
--IFSIVSS----TANQRPSSVKSTTSE-----TDVVGARERL----AETPSFCLSGGSP
DFS--GSCDQMERFLLQEDIE-----ALMDPTSTTMSSSSLGPEAPRAPF-YQPAAY---
--------ASLAR-PGE------------KARPL--------------L-PQRVHSEPLI
SWK------APFIL---DQ--SQRAPPV--------------------------------
----------P------AASQRAPPVPVSHQK----------APPAPAPS--QRAPRIPA
-PSQRGPRVPAPSQGAPRVPAPSQRAPVIPSPYLKTPAVPTPY-LKTPAVPAPSQRAPAV
PTPYLKTPAIPAPSQRA-PAVPTPYLKTPAVPATSQRAPLAPAVPQKARSLILPGGDVLE
RSKPKGKPE--L---V------------VGAQEVNVVELRTQATSLELPFT--TA-RESQ
EVLISKSWEISLEGLTGRRKLEGRAHGKK-EEFSLDLGGIKSKEVERQKRWVKIQAAALE
EPLKEDTRPFSVEGLALAKLIIMASS---KEQ-QLRPQ-AVTLPSWLSLTPKGSAVSREG
--SELFDLKQVSWLERTPVEVREQPESSVWTKESTKHWRKVEELPRHLMEDSKV------
---SFHALSPSSSPSMESGPRPPIALPATRWEDVEPQPIPLTP-----SKRDVKARMSQQ
PLRTPEEAI-----------------------------------------GMPSQPSLAV
TGSSSSMLFPVLVGTDSIRGSAPSVPMVKEEARSFTALPRLGHGGERKWALKGD------
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-------------------------MNADFLLPY-YTAQSG--SSMSMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GQA----TKRKKR--KAAKNLEL---TRLLPL-----
KFVR-ISVQDHE--------KQQLRLKFATGRSCY-------LQLCPA---LNTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WMPVFQEDRR-S-------L-G-
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------------ALNL------------QGKGD---QDHV-SIQS---LH-MV-SEVCGA
TSA-AY---------AGGEGLQNDFHKPTNVLNVSIPKTSTE-LA-EE-P-AT-------
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---------------G-AIKEAAAAG---------AAAGTAT--GTIAGALS-VAAA---
--N-SA-PG-QVST-AIAGA-------------------------ATI-GAGGNKSNMAL
AGT-------ASM-APNSTKVAVAGAAGKSSEHV---S--SASMSLSREG-SVSLAIAGV
VL-TSRTAAETDM--DAAA------------GPPVSTRQSKSSLSGQHGR--ERTQASAE
GCK------EG-----RERREKDRALGR-SSHRRRTG---------------------ES
RHKTRGDKIARKSSSRS-SFSHRANRD--------------------DKN--EKGCGNPG
-SSRHG-DSHKGVSHTPISKESRT-----SHKSGRSLSTTISG-----S-SK--------
-GLGRISSFLRNVRANLTTKAVG---------TPHGG---DVDIMAKMAE-RSTNVAIAE
TAEGGQGLE-MV-GSMTPDI-------------METVTFEAH------------------
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------------------------TMGG-------RSLRCS--VVPACA----PEGPGWL
QRHLLSG-EFD-QLRN-----FTIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPTKEDG----------------------------C----PQL---LGLFPL-----
QFVQ-LFIHDES--------RQQLKVKFCTGRAFY-------LQLRAP---AETRALEFS
KWVR--------------------------LLYRL--RFH------------------GQ
GAVPFTQEEW-------GDE---DWDEE---TD--LEDQERD-WRDQV------------
--------------------------------------KG--GLS---------------
------------RAREAGR---------------------------------------EV
GTWGLRGEPRPLLNLKG---CD-------TQ---A------DSSI---------------
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-------------------------------------MSSVPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGESN--PGVAL-----GVEEGLL
CQMLHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KG-GRNWREIHIASNTTALGVTSSVPCLPL----PNI--------L
LMANVKWHQGQ-------------------SQTWNRP-STVPNIFL---KRILPL-----
KFVE-LQVCDRH--------QRILRLRTVTEKMYY-------LKLHPD-----HPETVFH
FWIRLIQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-GQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QKHLSFRSSKKV-------ESNRN
SSEK--------------------GSSG--EDSIP--CT----------RDLRWRASFTS
GEWERENPS-GLQP--------------LSLLSTLAASSGPQ------------------
----------------------------LAPPIGNSI-----------------------
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-------------------------MKKNKR--E-SI---------------DEHDPGHL
QNMLDGG-GYA-PFVS-----PPMIQS------NFI--Q---------------------
-VN------------R-RGESIYVHDRANWVTVGICSSSSTH----KIPNV--------M
LLAHLKPTAQKH-----------GKPL---FKSLLTS-P-TEKLVL---TRFLPL-----
QFVT-LSVHNAE--------NMCLNVKLVSGRAYY-------LQLCVP---ANKKDALFS
QWMDLICLLHQEKAKAS--KVSEVSS-LSEITNST--EVTSSMAIMDIT-----AFN---
---------PIHVTESIHFSEFSDITDI---TDVTDIPENEV-ME---CPDVR-------
---------I-----I---------MEVTEVIEAIEATEV-------KNT-SDATNFSGV
TVVFENDDIIR--AKQEEKV-LENFLKPGCLRDTR-SKSEFKQ-----------------
---------TS--------------------------------------------K----
--------------------HVTISN-ITLTFKGERCFQTSLTPIKNETNIS---K----
--EMS-NETSEEMKTDFKNTAFKTESRKWSGILASVT--EF----ISCPL----KQQNFQ
CQSLIHSLNI--------------------------------------------------
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------------------------------------MLSSVPQRKT-QWKSK---KTVQV
TRSYPIFP-------------SLNVGEEVRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KK-GRNWIDVYKASNTMAVGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-SKAPNIIL---KRILPL-----
KFVE-LQVCDRL--------QRILRLRTVTEKIYY-------LRLHPD-----HPETVFR
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNSCSPSGD-SNL-VQKKPQACK
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------PRQL--RSS----K--K-TQTKRD
-S-P--------------------EKDTPSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQP--------------LSLLSTLAASMGPQ------------------
----------------------------LSPLIGNCI-----------------------
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------------------------------MMRGPET-------KPAP------------
---------------GGA--------------------ECP--LVPAYP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKDNG----------------------------R----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAE
GAVPFTQEYL-------TME---DGEYD---EDDEDEEEDDL-IEREELQ----------
------------------------------------------EDM---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
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------------------------------------MLTSVPHRKT--CKLK---KTVKV
TKSYPTFP-------------SLNAWEEFRGL-LPADTELN--SGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SMVFES------NFV--Q---------------------
-V------------KR-GRNWMNICKTSNTMALGVTSSVPCLPL----PNI--------L
LMASVRWHQGQ-------------------SQTWNRP-ATAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QRILRLRTVTEKIYY-------LKLHPD-----HPQTVFH
FWVRLVQILKEGLSITTKD---PRIL----VTHCLVPKNNCSPSED-TKL-IQKKLQAPK
PSESL--MQLMAKGESEALSQIFD------------------------------------
--------------DLHQ------------------QKRFRNNKKVKMN-----------
KGCS--------------------GNGGCRKDDIP--CT----------HDFSWRDSLTH
GEWERENPS-GPQP--------------LSLLSTLAASTRPQ------------------
----------------------------LAPPIGMSR-GLRGQP-GVPPQS---------
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-------------------------MKKSNR--K-SPTRID--EKDDICVPD-SKDPGEL
QNMLNGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPTT----KTPNV--------M
LLAHLTPTAQKD-----------SEPL---FTSLLTS-PSPENLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRIKVKLVSGRAYY-------LQLCAP---ACKQEALFC
QWVELISLLNKEKAKAS--KVSEVSS-LSEITNST--DITGSVDIMDIA-----AFPAIQ
TSHLSTCSDPNNDVESVDFSEFTDITDV---TDVTDIPENEV-TE---APDIN-------
---------I-----V---------TEVTEVTD---I--------------CGVTASSGV
RVVFENDDILK--AKQEEKEKMENILKSGCLRDTK-SKNEFRE-----------------
---------SP--------------------------------------------K----
--------------------RVTISN-LALTFEGERCFQTTLTPEEDETEKS---K----
--EMS-DRPREIRTMDSESTTLKAEEPRSRRTDSD---T---SDKC-K------------
LLN---------------------------------------------------------
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-------------------------MSKIRGLPPEV-KEPC--SGVEL-----GVENGLL
CQLIHSA-EFN-LFSN-----SVVFES------NFI--Q---------------------
-V------------TK-SGRWMNLGEDSNTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGQ-------------------LSTCSTP-GLAPVVTL---SRILPL-----
RYVE-LQIYDRP--------QRILQVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWTRLVRILWKGLSITTKD---PRIR----ITHCLVPKLPRFSTKT--TP-ESSLPGSSQ
PSETL--LLLAAEQTNSSFSELSG------------------------------------
--------------RTQL----------------------TANRSTD-------TAIKID
SSSS--------------------C-KTPLPVVSQ--VN----------VNIPMRATLSH
SLWEQDDPN-EHLL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
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------------------------------------EMSSVPHGKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDREPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------NQTWTRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETNKN
RSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHSRVRMVTVGIVCTSPILSL----PDV--------M
VLARPIKIC-EEHVRR-------GRF----AKGRGR--SPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLIYLLRPPVESYCST---STLL----TGDAAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHRMASAASPSTSTPAAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGTATGPRTDVAIAGAATSP--ATGAMT-IAT----
-TK-SAGPG-QVTP-ALEGA-------------------------AIK-NPGENKSSKSM
AGA-------ANI-SSDGVSLALVGAASTSSEGTS--TTMAGAASLSQDS-SLSAAFAGS
MM-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSHPSAK
AWN------EKKER--RE-KDRHP--SRKSSHHRKAG---------------------ES
HRRTAGDK-NQKASSHRSVSGHKNTRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHRSTKKESRT-----TQELGKNRSASSTG-----PLRK--------
-KASKISSFLRSLRATPGSKTRV---------TSYDR---EIDIVAKMAE-KQNIEAKVE
KAQGGQELEMIS-GTMTSET-------------TEMIVFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGQPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPD-----SVVFES------NFI--Q---------------------
-V------------KR-GRNWRDVYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------NQTWNRP-SVAPNIFL---KRILPL-----
KFVE-LQVCDHY--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCSSPSGD-SKL-VQKKFQASQ
PSESL--IQLMTKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQL--RSSRKV-------ETNKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALAFS-LRA----
-G--S-DPR--VLR-----VIPESCGVWS--RNAGHRDLSP-LFPTGLSKTMMCGTSRAP
RVP--------------PDAVDAIDAFSCCMGGV------RDLLCRLPMWSFLSFPFLEL
L-----------K----------------------------GLLTAWVG-MQRVKRK---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPKV-REPG--PGVAL-----GVENGLL
CRLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-V------------NK-PTDWMDVWEGSTPIILGVTSSVPSLPL----PNV--------L
LMANVTWPQNQ-------------------FSTWNT--PRVPVITL---SRILPL-----
KYVE-LQIYDRT--------QRILRLRTVTEKIYY-------LRLHDK-----HPEAVFQ
FWIRLVRILQKGLSITTKD---PRIQ----FTHCLVPKMPSPSTET--T--VSSLSSSSQ
TSETL--RLLAAEQKSGSCLGLST------------------------------------
--------------RTQL----------------------TSNRNTQ-------TAIEIG
SCH---------------------SYKKPSLVTSP--FN----------LNIPMRATLNH
SLWEQEDPD-EHFL-----------------QVPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGAGL-----GVEEGLL
CRVVHSP-EFN-LFLD-----SVVFES------NFI--Q---------------------
-V------------KR-GRNWRDVYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------NQTWNRP-SIAPNIFL---KRILPL-----
RFVE-LQVCDHY--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCSSPSGD-SKL-VQKKLQASQ
PSESL--IQLMTKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSRKV-------ETNKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPHRKT-WKKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQMLHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
------------------------------------------------------------
---------------------------------------------------ILPL-----
KFVE-LQVCDCH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLIQILQKGLSITTKD---RRIL----FTHCLVPKNCCSPSGD-SKL-EQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNHLSFRSSKKV-------ETKKN
SSEK--------------------DSSG--EDSIP--CT----------YDLRWRASFTY
GEWERENPS-GLQP--------------LSLLNTLVASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSRESLLPY-HTAQSG--AGAGLFN----TTMGKL
QRQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPLLPL----PDV--------M
LLARPATGC-DDHAGR-------SQT----TKAKNR--KAAKTLEL---TRLLPL-----
KFVR-ISIHDRE--------KQQLRLKFATGRSCY-------LHLCPP---LDSREDLFT
YWEKLVYLLRPPVDSQSST---YAIP----AGDMI--CMPMFEE-DRRS-------P-T-
------------------------------------------------------------
------------AMDF------------QGRGD---QDQV-SVRS---LH-AG-SEVAGA
TSA-AF---------AGGEGLPLDFYNPDPVPSGAMANTKPRELD-EE-SA-A-------
------------------------------------------------------------
---------------G-AMMQVATAD---------ATEGD-------------LNMT---
--E-FHASE-ERSM-AIEVT-------------------------VTK-GPEGNKSNIAM
GGA-------AKT-SLRTRKRALAHGAKNLEYPS------STSTSLSPEA-SMSMV--GV
EA-TRKTTKGKAY--QEDE------------GTLISALPQEDQDSEQEDRPRRVS----Q
AHR------GRRER--REHRQKERALR--GSRPRGSS---------------------EG
RHKTVGDKAIRKTAGRS-SGGRRATRD--------------------DKK--EKGHGSPG
-DSKRG-TVHKGVSHAPITKESRT-----SHKSARSLSTGSSL-----STNK--------
-RLSRISSFLRNVRANLTTKTVA---------LSHDK---DVDILAKAVE-RKRMEAIME
TAESGQGLE-IA-GSVTSEA-------------TETVTVAAHQ-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-TTMRIN--KQDALCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICFSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TETL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMSLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMDVTDVT-----TFTAIL
TPYMYAGTGPEHVRDSIDFPEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EMK-DKTSEEKMPDFQSTALKAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSAP-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------IFV--Q---------------------
-V------------TK-PGNWMDDCEGPTTVILGVTSSVPSLPL----PNI--------L
LMANVTWPQGQ-------------------FSTWSTP-GSAPVITL---SRILPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPETVFQ
FWIRLVNILQRGLSITTKD---PRIR----ISHCLVPKLPCRSAE---TS-ESSLPSSSQ
PSESS--MLLAAEQNSDRFLNLSG------------------------------------
--------------TSQL----------------------TVPRNTS-------SATEIE
NFNC--------------------NDNTSLPASSP--VI----------SNIPMRATLSH
SLWEQENAD-EYNM-----------------QAPVASSLG--------------------
----------------------------------ENFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------FALVSNS------DFM--Q---------------------
-IS------------K-GGGVIDVHNHPRMVTVGIAST-SPL----PLPDV--------M
LLARPATSCHDHVG--------RGQA----TKGRGH--KAAETLEL---TRLLPL-----
-VVR-TSVHDRQ--------KQQLRLKFAPGRSCF-------LQLCPP---LHARETSF-
HWEELIHLPRPPGDSRSST---HAVP----ARPGW--RKR-----------------RGQ
P----------------------------------------S-AATAGPGGPG--PGEPQ
DPPHSLGVSGASSPLMP-------------------------------------------
-----------------------GGGDQICPPKPT-T---KPDTA-K-----PTRP---A
TGAAA------------------------------GAVAG-AAARAPGRAPCG--R----
--------------------H-------------------------RAAAVA---G----
--AAAKGPG----DS---------------------------------------NSSLAV
AGV--ADVP------WRNIKVAVAGAASQAPERTASA---AGSTALS-RA-QLSVALGRS
SGH-QPGAGTAQD-SA-------------AGPPEDRKTQQEARKERRER-RERRDKDRAP
SRT---------------G--SR----RH-----SAG---------------------DS
RSKSGSRK-GARSSGRSLSSRRSP-RE--------------------ERK--ERGRGSPG
-RSRRSSAHEGVTTR--------------GHQSGRSPSRVRAS-----CTCK--------
-RLGRSSSSLRRGKATTSTTSAA----------QLSRDVD---LVPKRVE-RSSVEAILE
AA----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTVGDK-NQKPSSHRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHNR---EVDIVAKMVE-KQNVEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSG-----------------
---------------------AKRTVSSEYVLPY-YTARDY--RGMGVFN----NSMGDL
QWQLYKGGEYE-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPMLPL----PDV--------M
LLARPAKAC-DEHVKR-------GPL----TKKRNQ--KPSRTLEL---TRLLPL-----
KFVK-ISVHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYILRRPADSSSST---PTVQ----TADTAC-S-----DD-KSL-------L-VS
------RWR--------------GE-----------------------NPREGSSDFVLC
FTCPL-CPPLAQASDL------------YEEEA---LDS-----G---LL-KL-SEVCGA
TSS-AF---------AGGEGIQLATAA-AGS-----------------------------
------------------------------------------------------------
----------TKGGTATTTGGVAAVGSTTSSTTGMVIAGTTTRPGATAGAMG-LAA----
-TK-SASSG-QVTT-ALAGT-------------------------ATK-EPGKDVASKAM
AAS-------ANL-SSEDIKVLLAGAATSTSSMGT---STAGATSISQDN-SMNMVFAGA
MT-TSGPVREKAA--QSQA------------APLVSTLQSE-----------------AE
ARK------EKRGR--REKKDRNA--SKKSSHHHRTGERH--------------------
GHRSGGDK-SRKSTAHLSVSGHKNKRD--------------------ERK--EKRRSHTR
-SKGHG-SSHKG--------ESRS-----SHKVGKKRSSASSS-----SLSK--------
-KSSKISSFFRNFITVPASKTTI---------TSADR---EVGIVSKTVE-KCNIQAKVE
TGQKGQELE-IS-GTMMSET-------------KETVI----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MAMKRESLLPY-YTAQSG--SEVGMFN----TAMGKL
QQQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAP-F-DELPGH-------GQST--SIKGKKR--KAGKTLEL---TRLLPL-----
KFVR-ISVHKRD--------QQQLHLKFATGRSCY-------LQLCPP---PESKDDLFS
YWEKLIDLLRPPVDSNSST---YAIP----AGDMM--NMPFLDEELKVP-------NRKK
GNR---------------------------------------------------------
----------RKKGGH------------RKKGE---PDQV-SVKS---LP-MATTDVSAI
NSS-AF---------AGGEGTHHDSDISTIVSRIPTPKISSKVLA-RE-SA---------
------------------------------------------------------------
-------------------------------------SEAIM--CDLVDSLS-LAAS---
--M-PEGLE-QINK-ATVGE-------------------------AVV-GARGSKSHLTI
TSP-------GKM-SPKNMKIALAGMASRSLEYI---P--NSPTSLSRKE-IMTITNPRI
ET-TGESVGETAN--DPVP------------VVLALTLPSESRSREETG-RQKARETDTK
AHK------ERRSR--RDQRAKERVGSR-SEHHQRTG---------------------EG
H-KTAGDKDFRKSASHR-CVG-----D--------------------NEK--------DK
-GSKRN-RWHKGVCHVPITKESQS-----SHKLSRTISTASSA-----STSK--------
-RMGRISLFLRNIRASLAGKGLA---------P-RGQ---DVGIMTKTLE-TTDVKAIME
A-EDGQGLE-II-DSVTSEV-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNKIRGLPPEV-REPG--PGVEL-----GVEDGLL
CQLLHSP-EFN-LFSD-----SVVFES------YFI--Q---------------------
-V------------TE-PGNWMDVCEGSTTMILGVTSSVPSLPL----PNV--------L
LMANVTWPRSR-------------------FSTQSTP-GHAPVITL---RRILPL-----
KYVE-LRICDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSSNCPET--TP-ESSLPSSSQ
PSETL--MLQAAEQTSGSFSQLSS------------------------------------
--------------RPQL----------------------TADRSID-------TAIGIS
SSI---------------------RDKTPLPVVSS--VN----------LKVPMRATLQH
SLWEQEDPD-EHFL-----------------HVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPHRKT-WWKWK---KTVKV
TRSYPTFS-------------SPNAWKAFRGL-LPVDGEPN--PGVGL-----GVVEGLL
CQKVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWLDIHKASDTTALGVTSSVPCLPL----PNI--------I
LMASVKWHQGQ-------------------SQTWNRP-STAPSIFL---KRILPL-----
KFVE-LQVCDRL--------QRILRLRTITEKIYY-------LKLHSD-----HPETVFH
FWIQLVEILQKGLSITTKD---PRIL----VTHCLVPTDYCSPSGD-AKL-VQKKLPASQ
PSESL--IQLVAKEESEVLSQILA------------------------------------
--------------DLHQ------------------QHQPSFRSSKKA-------ETNKH
S--S--------------------EKETPCEDSIP--CT----------RDLHWRDSFMN
GEWERENPS-GPQP--------------LSLLSTLAASTRPQ------------------
----------------------------LAPPIGNLI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKR--LLNT-RRTQPP--QDTQKW----VPILGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGAPAFVHHRTNKLTMGVAASLPGL----VLPDI--------L
LLARPPE--G----------------------------KEPSNLSL---TRMIPL-----
DLAH-LYVHDLP--------SWRLKLRLITGRYYY-------LELDAP---DHELGFLFD
RWIRLINLLHEPTISWAPR---TMGT----L--AL--DTP-----------------LG-
------------------------------------GTPAST-WRLQVGIQTA-----VE
VAERTFPYKI--FSSQKQRKSK-----------TVKQ-KLKSQAV-------------GD
SLPLIWSQLQPAEEQVEVTEK--KSYVDACPDGSK-TLIHVS------------------
------------------------------------------------------------
--------------------------------------------EKASITIR---T----
--IFSIISG----TMNQEH-------SN-----SKATTGRGGL----IETPTQCVPRDSP
DLPFVDSCDDMDTFLWTQDLE-----DLIDTESTTLSSP--LHPSYPPAF-YIFPQA---
--------SSRPK-SGD------------KARPAGPKKQAKP-----LS-SQKAASVPAT
SGK------TPFIL---DQ--SNKVPAE--------------------------------
----------P------APTQKAPTLPAPSQK----------APAAPWSA--QKSSTVPS
-LYYKAPPP--VSQKAPPVPGPPRKVAVLVSPPQKTVPPAPKL-QQAPAAPQKA------
-VPPKKDLVPNTQSQKA-PTVRHQK-----PPDSKAKPSGDAS--------VVPAGDTL-
QRKPEGKQEPVV---L------------MGGQKTKVVDMRTQATTLQLPNA--TTKKQSK
EILISKTQEFTLEGLKARSKMEDKAHKMK-EETTVNLPDLKSKETGTQKKWVLTQEVAVE
GPHPEDTRPFSVEGLALAKMMIMSNS---KQQ-HVEPA-AVSLPSWFSMTSRGSNMSVLA
--NLPFNSSHMTLPEGRHVEVRERPSSQTRVKENTQPQRERKLPTDDSCNSDGRI-----
--------------FMGRVHSRELELPNTA------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGEL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHARH-------ARTT---TKGRGR--KPTKILEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVDSSSST---PTLP----TREGAN-L-----EDDKSL-------M---
------------------------------------------------------------
------------TTEL------------HGEGD---QDEF----R---LH-KP-REVSRA
NSS-AY---------AGGEGIHHGHRGMPSSPAVMRSAGMAKGAA-NR-AAS--------
------------------------------------------------------------
--------------------GMAVAGSATSSTAGLAVAGAKTSS--SSGALS-LAA----
-TK-STSTG-QVST-ALSGA-------------------------TVK-CPGESGSNKAI
AGA-------VNI-SSEGTNVA-LGAASMSSVGAS--TLTTGAASISPGS-SMSVVFAGT
MT-TGTAAAER-SG-CLVV------------GPLVSTLQSEGYMSERDG-SQKVSQPNAE
TRK------GKKER--REKKDRTS--SRKSSHHHRTGECHHRTGEGHHRRGERHHRTGEG
HHRTGGNKSTRKSSSHRSLSGHDK-RD--------------------DRK--EKGQSHAR
-SRGH--SSHKSGTHGSAARVSRT-----AHKLGKIKSANSSS-----AISK--------
-KSSKIGSFFRNLRAMPGSKTGV---------PSHDR---EVDFVAKSLE-KCNIETKVE
KTPDGKDLE-IC-STMTSES-------------METIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLPSTPPSGRPWQKSK---KILDV
QRCYQAYH-------------CPDSTMVIRGL-PPAIEEPD--PGVEL-----GVEDGLL
CQLLHSP-EFN-LFPN-----SAVFES------NFI--Q---------------------
-V------------TK-YNNWRNIYDSSTTVALGVTSSVPCLPL----PNI--------L
LMAKVKWPKGQ-------------------SPKWICP-IEMPTITL---KRILPL-----
KFVE-LQVCNWS--------QRILRVRTVAEKIYY-------LKLHID-----HPEVVFQ
FWVRLLCILDRGLSITTKD---PRIH----VPHCLVPKVCKSSGNGPEAV-ENSKPLPAG
PSESL--ALLMAKGMSEASKRPAN------------------------------------
--------------LTHH------------------KKPVRTTDINLMEI--I-RDIQAR
-NPE--------------------QESSSQETIQR--NK----------GDLCLRDSFSH
SMWERENPS-GLQS--------------LSLLSTLAASIHCF------------------
----------------------------GPQP----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPQRKT-WWKSK---KTVKV
TRSFPTFP-------------SLNAWEEVRGL-LSVDGEPN--PGVGL-----GVEEGLL
CQMLRSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------RK-GRNWIDIYKPSNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIKL---KRILPL-----
KFVE-FQVCDRL--------QRILRLRTVTEKIYY-------LRLHQD-----HPETVFH
FWIRLVQILHTGLSITTKD---PRIL----FTHCLVPRINCSPSGD-SHS-VQKKSQVSQ
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------HDEFSSRSS----K--K-TQTKKD
-S-S--------------------ERETHREDGIP--CI----------RDLSWRNSLTY
GEWERENPS-GPQP--------------LSLLSTLAASTGLQ------------------
----------------------------LAPLIGRSL-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--SSMSAFK----TSMGDL
QRQLYNRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLAQPTKIC-EQHVRR-------GRF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLIYLLRPPVESYCST---PTLL----SGDAPS-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGTASAASPSTSTPGAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGTATGPRTDVAIAGAATSP--VTGAMS-IAT----
-TK-SAGPG-QVTT-ALTGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSEGTS--TSMAGAASLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSQPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAG---------------------ES
HRRRAGDK-NQKASSH----------------------------------------RNVR
-GKRHG-SSRKSSTHSSTKKESRT-----TQELGKNQSASSTG-----ALHK--------
-KASKISSFLRSLRATPGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTMTSEK-------------TEMIVFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNKIRGLPREV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SMVFES------NFI--Q---------------------
-V------------TK-PGNWLDVYKGSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGQ-------------------SSTRGTP-GCAPVITL---SRILPL-----
KYVE-LRICDRL--------QRILRVRTLTEKIYY-------LKLHEK-----HPEAVFQ
FWIRLVKILQQGLSITTKD---PRIQ----FTHCLVPKMSSSSTGT--TP-ESSLPSSSQ
PSESF--MLLAAEQTSGSFSHLAG------------------------------------
--------------RSQL----------------------PADRNTD-------PATEVD
NSDS--------------------CHKTLSPVVSP--IN----------MNVPMRAVLSH
SLWEQDNPD-EHFL-----------------QTPVASSLG--------------------
----------------------------------QNFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KAAP------------
---------------GGA--------------------DRP--LAPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRSP---PETRDCEFG
RWVR--------------------------LLYRL--RFH-----------------SPT
CAVPFTHEDT-------APE---EEEE--------E---EE---------EVK-------
--------------------E-----------GQLQPPEF--QAT---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDP-------KPVR------------
---------------GGA--------------------DRP--VVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKESG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHDES--------RHQLKVKFRTGRAFY-------LQLRAS---AETRDREFG
RWVR--------------------------LLYRL--RFH-----------------SPA
SAVPFTHEDT-------APE---EDEEE---EG-------------------E-------
--------------------Q-----------GQLQPPEV--R-----------------
---------------AGPR---------------------------------------AQ
GWLGLDPGSEGGGLGLDPGSEG-------GELGRA------RPESLG-------------
-----------------------------LNPH-----------------PL---L----
--LLLRDSK----EA---------------------A-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEVGFLFH
CWVRLINLLQEPAPTWGPR---TKRT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQEQPSSR---HAVR
VAEHNFPYKT--VAARRQRKAE-----------ALRR-SFKSQAV-------------GD
SLPLVWSQLEHADVRKKPAEK--KSHSDPCPDGTH-TQIR---F----------------
------------------------------------------------------------
-------------------------------------------SEKTSISIW---T----
--IFSIISS----TANQTRSSPKASLIP-----GV-------L----VPSPG-----VPD
PGYRLSSQ---------SGLL-----NVTDSEGSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-RRE------------KARPMGSHQGPGS-----PP-CQKAPSGPVT
SYK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASPWKPPPGLAPPQKAPAASAPPRKAPAVPAAS--QKASAASA
-PPRKAPAVPAASQKAPAASAPPQKAPAVPAPSQKT-----KA-PAVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALPTSPTQYQIALGPPASWGKLPGDFDVL----PTGIPGRAVLE
RSQSGGKPEPAV---T------------VRTQETDVVEMMTQAKSPESPFT--VTKMESK
DILVSQSEEVTLEALRGDRKLEDRAHWQKLEERSLGLPGVRSKELEQRKRWVKTKELAVE
GPSQEHSRLFSAEVPTLAKVMIMANS---KEQ-HSKPA-LVSLPSWLLVTSQASATSVMA
--SMPPRPGQLSSLEGKPVVVRGQPESHTWLKEGKRQWGE--------MEEPPWDPEGP-
PNVPFRSKPTSASLKRGGISQAPIPVPAAGWEDF--LPSS--LSESPISKMEATARAPQR
PKRALQEPV-----------------------------------------RMPAQHPLAT
VGSSSEILLPMLLELETLRDTATKAEEIQEESGVFNLPP---------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNNR--K-SPARTY--KQTSPCAPH-APSPGDL
QNMLDGG-EYA-PFIS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVAVGICSSSSIH----KTPNV--------M
LLAYLTPTAQKD-----------TEPL---FRSLLTS-PSTEKLVL---TRFLPL-----
QLVT-LSVHDAK--------NMRLKVKLVSGRAYY-------LQLCAP---ANKQDTLFS
QWVDLISLLNQEKAKVS--KVSEVSS-LSEITNST--EITGSVDIMDIA-----AFTAVQ
TPYVHAHSDSLYVMDSIGFSEFTDITDI---TDVTDVPESEV-PE---VPDVR-------
---------I-----V---------TEVIEV----------------TDN-SDVTNYSGV
TVVFENDDLIR--AKQEEKEKMENILKTGCLRNTK-SKGELKK-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFETTLTPVESEANML---K----
--KMG-GKTSEEKTTDSQTTALKTVGSRYLEENG----M---VP----------------
----LTHLQRKDHF-LFTEA--------------------A----------KVIFNV---
----------KV------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MAVASSFPGL----LLPDL--------V
LLARPVQS-K----------------------------KQPPRLEL---TRLLPA-----
QLVR-LFVHSEA--------GWRLKLRLASGRSFY-------LRLVAE---PAEGCLLFN
RWRFLIYLMQGPIPAWARS---PDEQ----AAQDE--SAP-----------------MSA
AEAPPKRKEV-------AF------PPQ---YPVPRTKGSPG-W----------------
TWDKALHYPGPLSQLMDQQSAQDL---------PEV----MSRAE-------------AA
PMSFRSQQ-KL-PVRREEKQK--RSTPGSL--------VEV-------------------
------------------------------------------------------------
-------------------------------------------EGQPSVTIR---T----
--LFSTISG----SHLSKAAAPA----E-----TSSSGPSRPP----SQEH---------
----PKEPGTANKLPLPQ------------------------EQPQPQEL-PQEQPQ---
-------PQELPQ-EQP------------QPQELPQDQLQGT-----SR-PKERDSSGEP
RTV------ALYIL---KK--LR--PGM--------------------------------
----------PGGSGGSAASLRKP--PGSPQSSPRTTRGTVRSPPRPHSP--APVSRLCG
-KPSRSHRAGSPE---HGNRAKRWSAPVPGAPANPLPRPPNCI---------------RF
FFYFFKIYFI--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-KEPGVEDGMEL-----GVEEGPL
CQLIHSP-EFN-LFSN-----SAVFES------NFT--Q---------------------
-V------------TE-PGNWMNVCEGSTTTILGVTSSEPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-SDAPVITL---SRILPL-----
KYVE-LRICDQV--------QRVLRVRTVTEKIYY-------LKLHEK-----HSEAMFQ
FWIRLVRILRKGLSITTKD---PRIQ----FTHCLVPKMPTSSTEA--TP-ESSLPSSSQ
PSETV--MLLAAEQTSGSFLQLSG------------------------------------
--------------RPQY----------------------TADRNID-------TAIETD
DFNC--------------------YHKIPSPVASP--VN----------VNIPMRATLTH
SLWEQEGPD-EQFQ-----------------QVPAASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSS--ELDF-K-------KITPSQ----KFIMGDL
QRLLNQG-EYA-LFAS----V-PMFES------RFV--Q---------------------
-IN------------Q-RGELINLHNRPTCVTIGVCAASSPMPSGMLLAHKVPVSPQEIM
ANLQKFSEHP----------------------------SQVEQLAL---SRFLPL-----
KFVE-LSVHSTD--------KKQLMLKLVNGRSYY-------LELCAP---PDQQQQLFH
HWLKLISLLKRPEDTSNTN---VNII----CK-DS--GTN-----------------HE-
---------------------------K---APSPNNPPDNS-NNSQNMPNTK-T-EEET
VTEQTSSNQV-------PHSGSVGPTEKSGRG----RATFSSSQEA--IR-LDATMQSKN
KDPLDTVNSRSKE-RRKSRTD--K----MKPKKEK--TSQPSGN----------------
------------------------------------------------------------
----------------------------------------RKSGSKSRIGCF---K----
--LYSR------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDALCTPH-SHDPGHL
QNMLDGE-EYA-PFVY-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------REPL---FKSLLIS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQVKAKVS--KVSEVSS-LSGITNST--DITGSMEVMDIT-----AFTAIP
TPYMHTGTGPVHVRDSIDFLEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TE---VRE---ATEV-------TDS-LDATKCSGV
TVMFENNGLIR--AKQEEEEKMKDILKPGYLQDTK-SKSELKE-----------------
---------FP--------------------------------------------K----
--------------------HITISN-ITVNFEGKGYFQTTLTPVESEANTS---K----
--EME-DKTSEEKTPDFKSTALKAEESRSLRTESNTS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------RDCCMTSY-YSAKSS--LAMSMFN----TSMGKL
QRQLYKG-EYP-IFQY-----APVFES------DFI--Q---------------------
-VS------------R-KGEVIDVHNRARMVTVGIVRTSPHLTL----PDV--------M
LLAQPAAIC-DDSNRH-------GPA----ARKRGK--KPTQILEL---TRLLPL-----
KFVE-ISIHNSK--------KQQLCLKLATGRSFY-------LQLCPP---TDR-GDLFI
QWKKLIYILRPSVNAHSRT---QATP----ARNIL--DITGSKKREEVP-------SG--
------------------------------------------------------------
------------KSQK--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-IS------------K-RGEVIDVHNRVRMVTVGIASTSPIL----PLPNV--------M
LLARPVVYLEDPPP--------FPEPG---SRSMLH--FPSKTLEL---TRLLPL-----
KFVK-ISVHDRD--------KQQLRLKLASGRSFY-------LQLCPP---SDAREDLFS
YWEKLIYLLRPPVEGYSST---HAIP----AGDGV--EVP--------------------
-----------------------------------------V-FMLQNDGGEG--DGNKE
IWCRSPPRTSPTLALCPESARK--------------------------------------
-----------------VEGLKNKGWGAGCVSMNK-SHPHAPDTL-G-----T-RQHTDS
ASWGWGFHQSPPLILMGLG--G-------SQPSAAGAADGGEAASAGEAFPCPGDT----
--------------------DRDLLT-HHYTIQGVPSVSPPSTPSVPSIAVA---V----
--AASRGPA----GKA-------------------TAGVTPGLGVA-VMESQGPGLSLAL
AGT--ATAQVTETMSAGSVSLVLAGAASMSPDSVSMVS--AGAGSLSPSG-PISVASAGA
GGLAVAGIGVIAP-PLE------------PEPPLVSTLQTEGYMSERDG-SQRLAPSSTP
EAV---------------K--EG----RSSRRRSRHR---------------------EG
RGRKGGEK-DAGGGGQKKSSRRAV-TS--------------------KDT--QKAGHRPR
-RSRRSPSSRKASS--PSIKDSRT-----SHKPGKTTA-----------PTK--------
-KPSRIASFLRSFSRSSQSTKST----------SVLTNVGGTAEAPKAVATEIDMSAILE
NME-STEMEMETITELVSPAEEEEEEEEEEEEELVSLLMDSQRPAPPLPCP--PESRH--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSVPHRKT--WKSK---KTVKV
TKSYPTFP-------------SLNAWEEFRGL-LPADAEPN--SGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWINIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVRWHQGQ-------------------SQTWNRP-ATAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QRILRLRTVTEKIYY-------LKLHPD-----HPQTVFR
FWIRLVQILKEGLSITTKD---PRIL----VTHCLVPKNNSTPSED-SKL-VQKKLQAPQ
PSESL--MQLMAKGESEALSQIFE------------------------------------
--------------DLHQ------------------QKCFRN-KKMKMN-----------
KACS--------------------EKAPSRKDDIP--CT----------HDFSWRESLTY
GEWERENPS-GPQP--------------LSLLSTLAASTRPR------------------
----------------------------LVPLIGTLR-GLIGLP----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MGSDCLSPY-CKAQIS--SAMGMFN----TTMGLL
-CQLYKG-EYD-NFKY-----APILES------DSI--Q---------------------
-IS------------K--GEVADEYNRVGMVTLHIACTSPTLPL----PDV--------M
LLASPATCC-EDHVVQ-------GQA----IKGRGH--KATKTLEL---TRFLTV-----
KFVR-ISVHELE--------KQQLRLF---CRSCN-------LQLCPP---LHAKEDLFT
YQEKLMYLLHLPVDTNSST---HAIP----GDTL---CMPGLEEEAGTG-------P-A-
------------------------------------------------------------
------------AADC------------QGKGD---HDQG-SIRS---LH-IV-SQVSGA
SSS-AYP--------GGGEGIKYAPHKPTTTPDTAKPTSPAKGAA-AG-TI---------
------------------------------------------------------------
------------------------------------AVTVAK--GAVAGAVS--------
-----GADT-EHSR-AVARA-------------------------ATK-GPRHSKSSLAV
AGV-------ATV-PSKNIKVAVAGAASQTTERT---VSTEGSTPLSREQ--PERGVPGA
AA-VKQPGAETAQ--DSAGP------------------------------PEDPKSGP-S
GRP------GRRGGRGGNCGARTALPAGRAPPQDRGL---------------------S-
RRKSGSHKVSEQSSGGS-LTSRRSPRE--------------------EQK-EKA--AAAE
-GSRRG-SAHKGLSRKPFA---RV-----SLTSGRSLSTVSSS-----STSK--------
-RLSSTSFFLRNLKASLSTKSAA---------QRSPR---DVDIVSKRVE-RSSREAILQ
TTECDQEAI-I--GARMLDT-------------VELVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNPESLLPY-HTAHSR--SARGMFN----TAMGKL
QRHLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPATGC-EEHGGR-------GQA----TKEKGH--KATKTLEL---TRLLPL-----
KFVR-ISIHNRE--------KQQLRLKFATGRSCY-------LQLCPA---LDTREDLFT
YWEKLVYLLRPPVDSNSST---YALP----A-DML--CMPVFEEEDERS-------P-A-
------------------------------------------------------------
------------GADF------------QGKGH---QDQV-SIRS---LH-VV-SEVAGA
TSA-AF---------AGGEGTRQASHKPDAAAATPK----PAELH-RE-SAAEPHVE---
---------------LAAA-----------VAAR--------------------------
---------EAAGAAA-VVTGGTAVG---------FAAGIAA--DTAAGALS-VALT---
--K-SAARD-RLGA-AVAGA-------------------------ATA-GPGGSRTNLAI
AGT-------ANL-SPESRNLALAGAAKIPGFAS---G---SSTGLSQRA-RRTPTFAGT
EG-ARKT----VA--GNVE------------RALLSDAQSGGAEGEQAGRQPR-------
--Q------GQR-----ERRDKERTFR--GSRRRRAA---------------------DT
RHEAGGDKINRKASGRS-LAGHRAARE--------------------DK--D-KARGSPG
-GGR-R-APHKGIGHAPIPKESRA-----SHKSGRSLSTASSG-----LATK--------
-RLGRIGLFLRNVKANLTTRTTG---------SLRGR---DVGVLPKAVD-RSGLEAIEA
--SNCQGLE-SA-GTGTSDI-------------METVTFEAP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSVPHRKT--WKSK---KTVKV
TKSYPSFP-------------SLNAWEEFRGL-LPADAELN--SGVGL-----GVEKGLL
CQMVRSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWKNIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-ATAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QRILQLRTVTEKIYY-------LKLHPD-----HPQTVFQ
FWIRLVQILKEGLSITTKD---PRIL----VTHCLVPKNSSSPSED-SKL-IQKKLQACQ
PSESF--MQLMGRGESEAVSRIFE------------------------------------
--------------DLHQ------------------QKRFRSNRKMKMN-----------
KTCS--------------------DKDASRKDDIP--CT----------HDFSWRDSLSH
GEWERENPS-GLQP--------------LSLLSTLAASTRPR------------------
----------------------------LAPPIGKCI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRPEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PFRA----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------GDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMCT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNFPYKKPPVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVGKKPAEK--KW--TYPPDRTH-TQGSDS-S----------------
------------------------------------------------------------
-------------------------------------------PIREDITIW---T----
--IFSIISS----TAKQTQSSPKACTSA-----SEEATGQGPV----VESPSYCVSADSP
DCFFLGSGSSLDPCLWHQDME-----DLMDSESSTLSSAASGLAPYPLAA-RLSTPY---
--------SSIPR-GRE------------KARSMGSHQGRGP-----PP-CQT---GPVT
SRK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWTPPPGLAPPQKVSAASAPP--------------------
-----------------------WKAPAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALQTSPPQYQMAPGSPASRGRLPGD--VL----PTGIPGRAALE
RSPSGGRPEPAV---T-VPAV------TVGTQETD-VVMTTQVKSLESPFT--VTKKESK
DILVSKTQEVTLEVFGGQGKLEDRAHLAKLEERSLDPPGARSKELEQRKRWVETKELAVE
GPSQELSRPFSVETLTLAKLTILANS---KEQ-RVKPS-LVSLPSWLLATSQASATSVMA
--SMPFHPGQLSSPEGKPVVVREQPESHTWVKEGKRQWGES--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQAPIPLPASRWEGL--PPSP--LSETPISKTEATAKASQQ
PKRLSQEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVFNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKRGREQ-------KPAL------------
---------------GGA--------------------GSP--LVPARP----ARRPGRL
QRCLLSG-EFD-QLRD-----LPMFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDEG--------RWQLKVKLRTGHCFP-------DQEPLAAPLPL--TSALG
PGVR--------------------------L--------S-----------------GPE
GAGPQGRGQA-------PVP---LVDPQ---GP-S----PAA-APPQV--KPV-------
--------------------R-----------PALSRAQP--QAV---------------
------------EARLDPQ---------------------------------------LS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCILPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPC---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNR--LQNI-RRLQPP--QGPPKW----VPILGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-RGGPVYVHHGINRLTMGVAASLPGL----MLPDI--------L
LIAQPPE--G----------------------------REGAGLVL---TRMIPL-----
DLVH-LYVHDLF--------TWRLKLRLVTGRYYY-------LELEAP---DSEVGFLFD
RWIRLINLLREPATTWAPR---AMHT----P--RL--DVP-----------------LA-
------------------------------------EPPAST-WHLQPS-----------
-----FPYKM--LAAHRQKKAA-----------APKR-RFRCQAV-------------GD
SVPLICSQLEHADVGKKSKEK--KSHPDTCPDSSY-TQIHAS------------------
------------------------------------------------------------
--------------------------------------------EKASVTIR---T----
--IFSIVSS----TANQTRSSAKAGTSD-----SGEATGQRRL----LETPSHCITEDSP
DFFFPCSYDHLDPYLWRYHIQ-----DLMDLESSTLSSTSFSVAPYPPPA-YLSAPY---
--------SSFPR-ASE------------KPRPTGSPQGRGP-----PP-SQRAPCVPVQ
SCK------APFIV---DQ--SQKIPAV--------------------------------
----------P------APSRKAPALRAPPQEALE--SSTWKALAVPGPS--QKAFTMPG
-PIRKAPRVSAVPWNPPAIPAPSRRAPPVSAVPRKA-------------PSAPA------
ISQKAVSLFLPGDSQKA-PTSPTQHQMARGSSTSWGNAPANFDLL----PTGLPDRDTLQ
RSKTEGKPEPAV---M------------VGTKQTDVVEMRTQTKSLELPFT--TTKKESE
DIMISKTREMTLEGLRGWGKSEDRMCRAK-EEMSLDLPGGRSKEVVQQRRWVKTQELAIE
GPPEEHSRPFSVEGLALAKMMIMANS---KEK-RLRAA-LVSLPSWLSVTSHTSATPTMG
--STPFSSNRLEGP---PVMVTEWPESHTWMKENKQQWTEMKEPPWDRARPSKV------
---PLHSKATSGSPKMESISQVPIPLPASRWEDL--PPSP--LVETPISRMEATARVLQQ
PTRTSQEPM-----------------------------------------TVPNQRPLAM
VGSFSKIILPTLVEIENTRDTAIQVEKIKEESPIFN------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------RMTSVPPRQS-WWNSK---KTVKV
IRPYPTFP-------------SLNAWEKFRGL-LPVEGEPN--PGVGL-----GVEEGLL
CQMVRSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RSGGRNWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-STAPSIIL---KSILPL-----
KFVE-LQICDHH--------ERVLRLRTVTEKIYF-------LKLHPD-----HPEIVFL
FWIRLVQILQKGLSITTKD---PSIL----VTHCLVPKSLCSPCGK-SEL-VPKKPQGPR
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------RKQYR--RSKKIQI--N-------
KTNA--------------------GKATPSENSVP--CT----------RDLSWRDALSY
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLTGGISI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MMRGHET-------NPTP------------
---------------GGAG-----GM-----------TGCP--LVPAFP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKDNG----------------------------C----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
GAVPFTQEYP-------TLE---EGEEE---EDDDDDEEDEL-IEREL------------
------------------------------------------QAT---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-THVPEAD---FQVTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FTTWSTP-GDAPVINL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIK----FTHCLVPKMPTNSTET--TP-ENSLLSSPQ
PSEPL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSH
SLWEQEDWN-EHLL-----------------QVHIASYLG--------------------
----------------------------------EHFLGA--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAI-RETG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNRMNNCEGSATIILGVTSSVPSLPL----PNV--------L
LMANVTWPQDQ-------------------FSNWTTS-SVAPIITL---SRILPL-----
KYVE-LQICDRS--------QRILRVRTVTEKIYY-------LRLHDQ-----HPQAVFQ
FWIRLVNILQKGLSITTKD---PRIQ----FTHCLVPKIPSSSTEA--T-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDALCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TETL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDME--------NMRLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALVSLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMDVADVT-----KFTAIL
TPYMYAGTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPAESEANTS---K----
--EME-DKTSEEKMPDFQSTALKAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLFAP-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MRK-------KKSSVD--EQGSLWLPQ-SPDLGHL
KNILDAG-EYG-SFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNGANWVTVGICSSNPIL----KTPNV--------M
LLAHLTPEARKE-----------SEPL---FKSLLTS-PSTEKVVL---TRFLPL-----
QFVT-LSVHSAK--------NMRLKVKLISGRAYY-------LQLCAP---VYKQDIIFS
QWVDLITLLYQKKARTS--KVSEVSS-LSEITNST--DITSSMDIMDIA-----AFAELR
AAHSHTRIHSANTTESADFSEYTDVTDITD---VTDVPENGA-TD---VPDIR-------
---------I-----V---------TEVTEVTE------------DVKEP-KEATNISEV
TIVFENDDIIK--AKQEEKE---NVLKHGCLRDTK-SKNQLRE-----------------
---------SP--------------------------------------------K----
--------------------HVTISN-LTLTFQGEKCFQTTLTPVKSEENIS---K----
--EKC-DKTLEGKMTDLPKTDLKAKESRSTRNDSNTSDGK-TK-----------------
----LGGYLLKQYP-L-REK--------------------SFTLGSQTRG-FVSLYL---
----------LLQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKP-WWNSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQIVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRHWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-STAPSIIL---KSILPL-----
KFVE-LQICDHH--------ERILRLRTVTEKIYF-------LKLHPD-----HPETVFL
FWIRLVQILQKGLSITTKD---PSIL----VTHCLVPKSLCNPCGK-SEL-VQKKPPCSR
PSESL--MQLMAQGESEALSQIFA------------------------------------
--------------DLHQ------------------QKQYR--RSKEMQI--N-------
KTSS--------------------EKATPSEDSIP--CT----------RDLSWRDAFTY
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLTGGTVMMGLIWWSSRDRLEFK-LRI----
-GTVS----------------------WG--PQGNSRGPHP-LPFCLLV-----------
-------------------------FASYAIE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNNR--K-SATRIN--EEDDICIPD-SQDPGEL
QNMLDGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSPTH----KIPNV--------M
LLAHLTPAAQKD-----------SEPL---FESLLTS-PSSEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRIKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNQEKAKAS--KVSEVSS-LSEITNST--DITGSVDIMDIA-----AFTAMQ
ASHLHTCSDP---IESTDFSEFTDVTDV---TDVTDVPENEI-TE---APDIR-------
---------I-----V---------TEVTEVTD---L--------------CDATGGSGV
TVVFENDDILR--AKQEEKDKTETILKPGCLRDTK-SRNEFRD-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-LTLTFEGERCIQTTLAPEENEMNKA---T----
--EMS-NRPSEIKTTDSKSTALKAEESRYVRFHWP--------FKC-K------------
LSNFKSR-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRPEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRA----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------GDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFR
CWIRLINLLQEPPPTWAPR---TMCT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQVGPQ-----LHIR
VAEHNFPYKKPQEATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVGKKPAEK--KSHPDFHPDRTH-TQVH---F----------------
------------------------------------------------------------
-------------------------------------------SEKTSITIW---T----
--IFSIISS----TAKQTQSSPKACTSA-----SEEATGQGPV----VESPSYCVSADSP
DCFFLGSGSSLAPCLWHQDME-----DLMDSESSTLSSAASGLAPYPPAA-RLSTPY---
--------SSILR-GRE------------KARSMGSHQGRGP-----PR-CQT---GPVT
SRK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWTPPPGLAPPQKISAASAPP--------------------
-----------------------WKAPAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALQTSPPQYQMAPGSPASRGRLPGD--ML----PTGIPGRAALE
RSPSGGRPEPAV---T----------------ETD-VVMTTQVKSLESPFT--VTKKESK
DILVSKTQEVTLEAFGGQGKLEDRAHLAKLEERSLDPPGARSNELEQRKRWVETKELAVE
GPSQKLSRPFSVETLTLAKLTILANS---KEQ-RVKPS-LVSLPSWLLATSQASATSVMA
--SMPFHPGQLSSPEGKPVVVREQPESHTWVKEGKRQWGES--------KGSSWDPEGP-
PKVPLRSKPTSASPKREGISQAPIPLPASRWEGL--PPSP--LSETPISKTEATAKASQQ
PKRLSQEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVFNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTANSY--RSMDVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHVRH-------TRT----TKGRGR--KPAKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVESCSST---PTLQ----TGDARI-L-----EGDKSL-------L---
------------------------------------------------------------
------------TTEL------------HRERD---HDAV----G---LH-KL-GDVSGA
SSC-AY---------VGGEGDYHVPHGSTTSLK---STEGGAAG--T---TS--------
------------------------------------------------------------
--------------------GLAVAGTTTSSGGGVAVAGVGAGS--VGGAVS-LAA----
-TR-STSTS-QVST-TLAGA-------------------------AAK-GSRESGSGKAI
VGA-------ASI-SSEGTNLVLAGAASTSSTGMD-----------SADS-SMSVVFAGA
VK-TGKAAAVSAE--GQVG------------APLVSTLQSEGYMSERDG-SQKVSHPRDE
TRK------EKKER--REKKDKSS--SRKSSRHRRTG---------------------EG
HHRTGGEK-TRKSSSHRSVSGHGNKRD--------------------DKK--EKGQSGTR
-GKGH--SPHKSGSHSSSGKEGRT-----ARKPGKSRSSTSSG-----TLNK--------
-RSSKISTFFRSFRVIPGSKPMV----------RHDR---EVDFVAKTVE-KRNIEAKVE
KAPVGEDVE-IH-GTVTSET-------------METIIIETKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSDSLLPY-YTAQSG--SGMSMFN----TTMGKL
QQQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GKA----TKRKKR--KAAKTLEL---TRLLPL-----
KFVR-ISVHDHE--------KQQLRLKFATGRSCY-------LQLCPA---LDTRDDLFA
YWEKLIYLLRPPMESNSST---CAIP----AEDVM--CMPVFEEERR-S-------L-G-
------------------------------------------------------------
------------AADL------------QGKGD---QDQV-SIRS---LH-VV-SEVCGA
TSA-AY---------AGGERLQHDFHKPTDNLNVSTPKTSTE-LA-EE-T-AT-------
------------------------------------------------------------
---------------G-VTKEAAAAG---------AAAGAAT--GSIAGALS-VAAA---
--K-SA-PG-QVSA-AIAGV-------------------------ATI-GAGGSKSNMAL
AGI-------ASM-APKSTEVAVAGAAGKSLECV---S--SASTSLSPEG-SVTLAIVGV
GP-TSRAAAETDT--DAAA------------GPPLSTQQSKSNLSGQHGI--ERTQARAE
ARK------ERRER--KERREKDRALRR-SFHRRRTG---------------------ES
RHKTRGDKIARKSSNRS-ASSHRASKD--------------------DKK--KKGHGSPG
-SGRHG-GSHKGASHTPILKESRT-----SHKSGRSLSTTSSG-----S-GK--------
-RLGRISSFLKNVRTNLTTK------------APHGR---DVDIMAKTVE-RSTMVAIAE
TVEGGQGLE-AP------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SAGLRKGLF-----LTAME--RSFQPW----VPLLGRL
QRTVMEG-EYL-PLGP----LLPMLES------DFL--Q---------------------
-VT------------S-QGEPIFLHNKENPVTMGVASSLPGR----LLPDL--------I
LLARPVGD-Q----------------------------KH-QGLEL---TRLLPT-----
DLAR-LSVHHVA--------SRRLKLRLASGRSFY-------LQLDAG---PREGCFLFN
RWRYLVYLLRRPRPAWGPQ---AHKD----QALGQ--GCK--------------------
------------------------------------LKGGGS-WGCGTSGSMK---EAAG
VWNTRFPREEAAGN-----KTKMS---------QAAKAKMMSRAV-------------GD
SIPFMTQL-ES-PGWKGEEKK--WAW----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESMLPY-YTAASG--RATGMFN----TSMGEL
QRQLYKG-EYD-PFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVGIASTSPVLPL----PNV--------M
LLARPIAAS-DDPQPP-------S--RFK-----HR--KSAKTLEL---TRLLPL-----
KFVK-ISIHDSD--------KQQLRLKLASGRSFY-------LQLCPP---SDAREDLFA
YWVKLIYLLRPPLEAYSST---QDGP----VGDTI--EVPML------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDAFCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----LPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMCLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALISLLNQEKAKVS--KVSEFSS-LSGITNST--DITGSTDVMDIT-----AFTAIL
TPYMYAGTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEI-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLENILKPGCLQDT--SKSDLKE-----------------
---------SS--------------------------------------------K----
--------------------RVTISN-ITLTFEGKRYSQTTLTPVESEANTS---K----
--EKE-DKTSKEKMPDFQSTALKAEESRSLRTESNTSVL---SPHIKS------------
PLNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNNR--K-PTARID--VQNALCVSH-AHGPGDL
QNMLDGG-EYA-LFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KTPSV--------M
LLAHLTPTVAKD-----------TEPL---FKSLLTS-CCTEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---AYNQDTEFS
QWVNLISLLNQEKAKVS--KVSEVSS-LSEITNST--EITGSIDIMNIA-----AFTAVR
TPYRHACTDPAHVMESIDFSEYTDITDI---TDVTDVPENEI-TE---VPDVR-------
---------I-----V---------TEITDV------TEV-------TDN-SDATNFSEV
TVVFENDDMIK--AKQEEKDKMKNILKPGCLRNTK-SKNEFKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISD-ITLTLEGKKCFQTTLTPVESEANIC---K----
--EMG-DKTSEDKTTDFQNPALKTLESRSMRIDSDTSAL---SPHIKS------------
SSNFLNVVPHLSPP-FSGER----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNR--LRNI-RLLRPP--QGRPKW----VPILGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-RGGPVYVHHGTNRLTMGVAASLPGL----MLPDI--------L
LIAQPPE--G----------------------------REGAGLIL---TRMIPL-----
DLVH-LYVHDLY--------AWRLKLRLVTGRYYY-------LELEAP---HNEVGFLFD
RWIRLINLLQEPATTWAPR---TMHT----P--PL--EVS-----------------LA-
------------------------------------EPPAST-WHLQVGPQLL---T---
VAQPTFPYKM--LKAHRQKKTM-----------AFKR-RFRSQAV-------------GD
SVPLIWSQLEHADTTKKSKEK--KSHPDTCPDGSY-TQIHAS------------------
------------------------------------------------------------
--------------------------------------------GKISPLPC---H----
--H----------RWPLTSIHLQAGTSD-----SDEATGERRL----LETPSHCISENGP
DFFFPHSYDHLEPFMWQQHIQ-----DLMDLESSTLSSTSFSLSPYPPSA-YLSTPY---
--------SSFPR-PSE------------KHRPTGSRQGQGP-----PP-SQRAPCVPVQ
SSK------APFIV---DQ--SQKIPAV--------------------------------
----------P------ALSRKAPVLQAPPHK----------ALAVPGPP--QKVFAMPG
-PIWKGPRVSAVPQKPPAIPAPSRRAPPVPAVPQKAPAVQAPR-LPQKTPSAAT------
ITQKGMSLFFPGSSQKP-PTLPTQHQMAHGLPTARGKPPVNFDLL----PTGPPGRDALQ
RNKTEGKPEQGV---T------------VGTKQTDVVAMRTQTKSLGVPFT--TTKKESE
DIMMGKTREMTLEGLRGWGKSEDRTHRAK-EEISLDLPGGRSKEVEQQKKWVKMQELAIE
DPPEEHRRPFSVEGLALAKMMIIANS---KEQ-RLRPT-LVSLPSWLSVTSHTSAMSTMG
--SMPFNSNQLKGP---SVTVREWPESHTWVKKNKQQWTEMKEPPWDTVRPSKA------
---HLRAKATSGSPKMEPVSQAPIPLPASQWEDL--PPSP--LMDSPISRMEATARLLQQ
PTRTSQEPV-----------------------------------------TVPNQRPVAR
AGSSSKIILPMLVEIDNMRDKDIKVEKIKEDPPIFNPPP-SGHTQQATWHRQIRRVRKWI
--------------------------------GGGN----------C--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDITNCSGV
TVVFENNDLIR--ARQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NTTSEEKTPDFQSMALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MLPY-YTAESS--PSMGMFN----TTMGKL
QWQLYKG-KYTTIFRY-----APMFES------DFI--Q---------------------
-IS------------K-TGEVTDVHNRAQMVTLAIVHSSPCLTL----PDV--------M
LLARPAVVC--DNARC-------GPD----TQERGS--LPAQLLEL---TRLLPL-----
IFVK-ISIHNSI--------KKQLHLKLATGRSFFFSFLFFFFFLCPP---SDASEDLFV
HWENLVYILRPSWLGTLQT---HLCL----RK-------------------------CT-
GA----------------------------------------------------------
------------YAMK------------FYEE----KEQI-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNRG--K-P---AD--EQDALCIPQ-PHRPGRL
KNMLDGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSPDY----KTPNV--------M
LLAHLTPAAQKD-----------TEPL---FKSLLTS-PSTEKLVL---TRSLPL-----
QLVK-LSVHDWK--------NMRLKVKLANGRAYY-------LQLCAP---LRKQEALFS
RWVHLISLLSKDRVKAS--QVSTFSS-LSEITNST--DVTGSADITDVA-----AFRELQ
PPPRPARPPSAHVLESADFSEITDVTDV---TDITDSPEDVA-EE---IPDIK-------
---------I-----V---------TEVTELIE---AMEV-------AHG-SGAIHASGV
TVVFENDDIIR--AKQEEKE---NVLKPGCLRNSI-SKKDLQD-----------------
---------SP--------------------------------------------K----
--------------------RVTISN-ITLTIQGERCFQTTLTPIKSEESIF---K----
--KMG-VETSEEKMTECKDTALKAPLQIFLKNNSECIHIQHAYMHSNGMG---KQQVIFI
CN----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------R-----AAMRR--LWRF-FFPPPP--PEPPKW----VPILGEM
QKTLQMA-EYL-PLRP----L-PMFES------NFT--Q---------------------
-VT------------N-NGSPALLHNKSNKLTMGVAASLPGL----VLPDI--------L
LIARPPE--D----------------------------EECSSLIL---TRMIPL-----
DLAR-LYVDDLP--------TWRLKLRLRSGRHYF-------LALDAP---EHELAFLFD
RWIRLINLLRGPKLSKTPK---T-------EHSLL--EIP-----------------PE-
------------------------------------VTLAST-WHFQVQSQGK---LTVE
VADPIFPCKI--FSSHKPKKTKMKLT------KPIKH-SLRSQAV-------------GD
SVPLIWSQLQSSEDQMKVTKN--KSYLHACSDRPE-RLIHVS------------------
------------------------------------------------------------
--------------------------------------------DKASITIR---T----
--IFSIISN----TINQAH------KCD-----SEEDTSQARL----IETPSKCISQNDT
GFPVVVPSSHLDTLLWAQNLE-----DLMSPEYATLSS---LNTSYPPAF-YIFPPN---
--------PSFLK-SKD------------KARPTGSKKHVSP-----LC-SHKAASVPIE
SRK------MPFIL---DQ--SNKVPAK--------------------------------
----------P------APAQMASALPTPSQK----------TPTALWSR--GKASAALG
-HFFKSQPS--DSQKTPTTPGHPWKPQVITAPTQKTLTPNQKL-LQAPAHSQKAM-----
-HTKKDHLIVNTRSQKD-PTAPYQK-----ALDSRAKALGDPRTL--------QGGGVL-
ERKTEGKQEPVL---L------------VGGQNTTVVDVRAQTMPLHLPFA--TTKKQSK
EILIGKTQ----EALKGREKLEDCAHKME-EETTVNLPNLKSKETEMQ-KWVLTKEIAVE
SPYTEDNRPFSAEGLALAKMKIMANS---KHH-QLKPA-TISLPSSFSVTSNVSSMSVLT
--NLPFNTSQTTFSDGSQVVVIEQSGSYTKVNKENTRHQMERKPAEDLPVSSNP------
----------------------RI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KPAP------------
---------------GGA--------------------DRP--LVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FAIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHNES--------RQQLKVKFRTGRAFY-------LQLRAP---AETRDREFG
RWVR--------------------------LLYRL--RFH-----------------SLA
CAVPFTHEDT-------APE---DEDEE-----EG-----E---------EGE-------
--------------------E-----------GQLRPPEV--------------------
--------------RVGPR---------------------------------------AR
GCWARKDGK-GPGRPAG------------SEGGRL------DPGCLGLREEGRRTR----
--------------------PGS-----LHVTH-----------------PF---L----
--LLLRGSK----EK---------------------ATGSGS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTAQSY--RSMGVFN----TSMGDL
QRQLNKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPVLPL----PDV--------M
LLARPTKVC-EEHARP-------ARP----TRRRGH--KATKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVESFSST---PTLQ----TTDAVT-T-----DDDKCL-------V---
------------------------------------------------------------
------------TTEH------------HGEGD---QDEF----R---LH-KL-RDVSGA
SSS-AY---------VGGEGIPHAPQRMTRSPIDMKTPGTAKGAA---------------
------------------------------------------------------------
--------------------------------TSVAIAGTATSP--AAGAVS-LAA----
-TK-SGGTG-QVNT-ALAGA-------------------------ATK-GPGESGSSKAI
AGA-------ANI-SSESTNVVLVGAASTSSLGTS--TGTTGAASVSPES-STSIVFAGA
LM-TNKPAAERAE--GPAI------------APLVSTLQSEGYMSERDG-SQKVSQPNTE
VRK------ERRER--REKKDRTT--TRKTSRHHRTG---------------------ES
HHRTGGDKSTKKSSSHRSLSSHGKARD--------------------DKK--ERGQSNKR
-GRGR--SSHKSASHGSTAKESRR-----AHKLGKSRSATSSG-----TVSK--------
-QSSRIGSFFRSFRVIPGSKAVV---------TKRDT---EVDIVAKTVE-KCNIEAKLE
KTPDGKDVE-IC-GTMTSET-------------METIIIEAKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEGQCMLPY-YTAESS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-TGELIDVHNRARMVTVAIVRTSPYLTL----PDV--------M
LLARPAVVC--DNARC-------GPA----TQERGS--PPAQLLEL---TRLLPL-----
MFVK-ISIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGNTS--DSSMFEEVHRSP-------MA--
------------------------------------------------------------
------------YAMK------------FCEE----KEQI-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKPVHQP-------KPAP------------
---------------GGAGEAGLGGM-----------AERP--LFPACP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------C----LQL---FGLFPL-----
QFVQ-LFVHDES--------RRELKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
GAVPFTQAYS-------ALE---DEEED---DD----EDDYD--ED--------------
-------------------------------------EDL--QAM---------------
------------EARLDPQ---------------------------------------IS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHGKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDQEPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------EINKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSG-----------------
---------------------AKRTVSSEYVLPY-YTARDY--RGMGVFN----NSMGDL
QWQLYKGEEYE-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPMLPL----PDV--------M
LLARPAKAC-DEHVKR-------GPL----TKKRNQ--KPSRTLEL---TRLLPL-----
KFVK-ISVHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRRPADSSSST---PTVQ----TADTAC-S-----DD-KSL-------L-VS
------RWR--------------GE-----------------------NPREGSSDFVLC
FTCPL-CPPLAQASDL------------YEEEA---LDS-----G---LL-KL-SEVCGA
TSS-AF---------AGGEGIQLATAA-AGS-----------------------------
------------------------------------------------------------
----------TKGGTATTTGGVAAVGSTTSSTTGMVIAGTTTRPGATAGAMG-LAA----
-TK-SASSG-QVTT-ALAGT-------------------------ATK-EPGKDVASKAM
AAS-------ANL-SSEDIKVLLAGAATSTSSMGT---STAGATSISQDN-SMNMVFAGA
MM-TSGPVREKAA--QSQA------------APLVSTLQSE-----------------AE
ARK------EKRGR--REKKDRNA--SKKSSHHHRTGERH--------------------
GHRSGGDK-SRKSTAHLSVSGHKNKRD--------------------ERK--EKRRSHTR
-SKGHG-SSHKG--------ESRS-----SHKVGKKRSSASSS-----SLSK--------
-KSSKISSFFRNFITVPASKTTI---------TSADR---EVGIVSKTVE-KCNIQAKVE
TGQKGQELE-IS-GTMMSET-------------KETVIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LSW-----------------
---------------------KKRTMSSECLLPY-YTANSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHVRH-------ART----TKGRGR--KPTKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVESCSST---PTLQ----TGDARI-L-----EGDKSL-------L---
------------------------------------------------------------
------------TAEL------------HRERD---HDAV----G---IH-KL-GDVSGA
SSC-AY---------VGGEGAYHAPHGSTTSLK---STEGGAAG--T---TS--------
------------------------------------------------------------
--------------------GLAIAGTTTSSGGGVAVAGVGAGS--VGGAVS-LAA----
-TR-SSSTS-QVST-TLAGA-------------------------ATK-GSGESGSGKAT
VGA-------ASI-SSEGTNLVLAGAASTSSTGVD-----------SADS-SMSVVFAGA
AT-TGKAAAASAE--GRVV------------APLVSTLQSEGYMSERDG-SQKVSHPRDE
TRK------EKKER--REKKDKSS--SRKSSRHRRTG---------------------EG
HHRTGGDK-TRKSSSHRSVSGHGNKRD--------------------DKK--EKGQSGTR
-GKGH--SPHKSGSHSSSGKEGRT-----ARKPGKSRSSTSSG-----TLNK--------
-RSSKISTFFRSFRVIPGSKPMV----------GHDR---EVDFVAKTVE-KRNVEAKVE
KAPVGEDVE-IH-GTVTSET-------------METIIIETKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------MSAFK----TSMGDL
QRQLYNRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLAQPTKIC-EQHVRR-------GRF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLIYLLRPPVESYCST---PTLL----SGDAPS-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGTASAASPSTSTPGAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGTATGPRTDVAIAGAATSP--VTGAMS-IAT----
-TK-SAGPG-QVTT-ALTGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSEGTS--TSMAGAASLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GQAV------------GPLISTLQSEGYMSERDG-SQKVSQPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAG---------------------ES
HRRRAGDK-NQKASSHRSASGHKNTRD--------------------DKK--EKGHSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----TQELGKNQSASSTG-----ALHK--------
-KASKISSFLRSLRATPGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTMTSEK-------------TEMIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------QPAMGSGCLFPS-YTAQSG--SAMGMFS----TAMGKL
QRQLRGG-EYD-LFRY-----APVFES------DFI--Q---------------------
-VS------------K-RGEVIDVHNRVRMVTVGIACTSPLLPL----PDV--------M
LLARPAPSC-EDQGGR-------GQA----TKGRGR--KAAKTLEL---TRLLPL-----
KFVR-ISVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LDAKEDLFT
LWEQLIYLLRPPVDSISST---HAVP----AGDVP--CVPGLEEEAGTR-------P-A-
------------------------------------------------------------
------------DAAC------------RGQGD---QDQA-SIRS---LH-MD-SEVSRA
SSS-AY---------AGGEGVEYAPHKSTTTPDTAKPTPPAKGAA-AG------------
------------------------------------------------------------
----------------------TM------------AVTAAK--GAVAGAVS-VAD----
--------T-EHST-AVAGA-------------------------ATK-GPGDSTSSLAV
AGV-------AYV-PSKNIEVAVAGAASQTTERA---ASTGGATASSPES-SLSVALAGA
AA-ADQPGAGTAQ--------------------------------DSAAGPPEDPKTQQE
ARK------ERREK--RDRRDKDRALSRTSSRRHATA---------------------HS
RRKAGSRKVGKKSSGGF-FTSRRSPRE--------------------EPK-GKKGRGSRG
-SSRRS-SAHRGYRRRPVAKESWA-----SPRSGRSRSTVSSS-----STSK--------
-RLSRISSFLRNLKASLSTKPAA---------QRRPR---AVDIASKRVE-RSR-ETFLE
AAECDQAMV--I-GARTSET-------------VETVAFEAS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSG-----------------
---------------------VKRTLSSEYALPY-YTAHNY--RSVGLFN----TSMGDL
QRQLYKGGEYE-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNHVRMVTVCIMSTSPILLL----PDV--------M
LLARPAKVC-DEHTRC-------SLL----TKKRSQ--KPKRTLEL---TRLLPL-----
KFVK-LSIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTRADLFC
YWEKLVYLLRPPAGSCSST---PMDQ----TGDAAT-P-----KD-KSL-------L---
------------------------------------------------------------
------------GSDL------------HGEGD---QDS-----M---VL-KL-HEVRGA
SSS-AY---------AGGEGIQQAA---AGS-----------------------------
------------------------------------------------------------
----------SKGEVAGTMSGVAVLGATTSPTAGMAMAGTVTGP--KGGATN-MAA----
-AK-STGLS-QVTT-AVAGT-------------------------ATK-DTAEGGSSKAM
AAA-------ANI-SSSDVNVVLVGAANTSSAGTS---TMVGTAGVTQDN-SVSVVFAGA
MT-TRAPVAEKAE--GSEV------------APLVSTLQSEGYMCERDG-SQKVPQVNAE
ARK------EKRER--REKKNRNA--SKKTSHHHRTGESH--------------------
HHRGDGDK-SQKSSSHWSVSGHGNKRT--------------------ERK--EKGQSKVR
-GRGHG-STHKSSSHSSANKESRT-----SHKLGKRRSAASSC-----SLRK--------
-KSSKISSFLRNFITVLCSKTAL---------ISRER---EGDVMAKKVE-KCNRDEDG-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVDL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------NFI--Q---------------------
-------------VTK-PGSWMDVYEGSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGQ-------------------FSTWSSP-DCAPVVTL---SRILPL-----
KFVE-LQICDRL--------QRILRVRTVTEKIYY-------LRLHEH-----HPEAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSNSSTEI--MP-ESSLLPSAQ
PSESF--MLLTAEQTSGSFSNITG------------------------------------
--------------RPQL----------------------TADSSTN-------VAIKID
NLDS--------------------S-KTPLRVASP--VS----------LKIPMRAALSH
SLWEQENPD-EHFL-----------------QAPVASSLG--------------------
----------------------------------ENFFGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SHASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-VN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNQ--LQNA-RRLERP--RGAPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VPSSRR-----------------------------------------------------
--------------------------------------PGATGSPS---PRMIPL-----
DLVR-LYVHDLS--------TWRLKLRLVSGRYYY-------LALDAP---EGEAGFLFD
RWIHLINLLQEPAATWAPR---TLHT----P--PL--DLS-----------------LD-
------------------------------------KAPAST-WHLQVGPQVH-RP----
---ECFPYKM--WTAQRQRKAK-----------AHKR-RFKSQAV-------------GD
SVPLIWSELEHTDVRSKALEK--KSHPDPSPGGSD-TQVRIP------------------
------------------------------------------------------------
--------------------------------------------GKGSITIK---T----
--IYSIVSS----TANQTQSSLQACTSD-----SDEASGRGRM----AETPPR-------
PGFFPSFCDHLDPYLWHQDID-----DLMDLESSTLSSASFDLAPYPPAT-YLS------
------------R-AGE------------TNRPVGSQQRPWL-----PP-CQKTPFFPAT
LCR------APFIV---DR--SQKVPAV--------------------------------
----------A------APSGKPSAVPGPSQKVPP----------VSAVP--QKAPAQTG
-TSQKTQAVSAISQKAPPTPGPSRKALAASAPLQKVLPPSKKT-LPAPTLPQKVM---SL
PVPKR---DIPATSQKV-PSSPIQQKMALSSPTSPGKHPASVHML----PGRIPGRDA--
-----GRPKREV---M------------VGTQETKTVKTRTQALSLELPFS--TTKKESE
DVLISKTREVTLRGWRGQGKVEDRARRAK-EETTLDLPGMRSKVAEQQKTWVKSQGLTVE
AP-QEHGRPFTAEGLAFAKLVITANS---KGP-RLKPT-WVSLPSWLSVTSQTSAVSAMA
--SVPFGPSRLSSLAGTPVVVREQPEPHTWVKEDVQQWTQGKEPPQGPAGPSKG------
---HLRSKPTPGSPKMELASQAPIPLPASQWEDL--PPTP--HSESPISKMEATVRMLQQ
TRRTA-------------------------------------------------------
--------EPVLLDMEGRRDSGTKAEKTK-ESGIFNPPPRYWELADV-------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KAAP------------
---------------GGA--------------------DRP--LAPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRSPPEPPETRDCEFG
RWVR--------------------------LLYRL--RFH-----------------SPT
CAVPFTHEDT-------APE---EEEEE------EE---EE---------EVK-------
--------------------E-----------GQLQPPEF--QAT---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKTSE---------S----GSVSIER-SSNKGNL
QTMLDEG-EYA-PFTS-----VPMLES------NFI--Q---------------------
-VN------------R-RGESVYLHNRANWVTVGICASSPNL----SFPNV--------M
LLAHLESNSKKE-----------DEPT---FDDFLSP-TSEVQLVL---SRVLPL-----
QFVT-ISVHDAP--------KMCLKVKLVSGRAYY-------LQLCAP---SHKQDVLFQ
QWIELISLLKSTTAFTVGQKVSKVHENIDKMTNA--------EDDIQINNEISEQLVYIQ
DPESD--------------------------TILENKPSNNI-T----------------
----------------------------------------------------------IS
EVAFEE-----------------------CESKSE-------------------------
------------------------------------------------------------
-------------------------------------VNNQISLKESETIIQ---K----
--EIN-DPDHDEKKIVVSEPATKAEGFRDSRNDLLTSGL---YSFSIFPL----ISLSFP
FSTFL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------T----
-------------------------MKRNKR--K-PTTRNN--EQDAISVPP-SQDPGDL
QNMLDGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSKTQ----KTPNV--------M
LLAHLTPEAQKD-----------KEPL---FQSLLIS-PSPENLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRIKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNEEKAKAS--KLSEISS-LSEITNST--DITGSMDIMDIA-----AFTAVE
TPHEYTCSDPVHAVESIDFSDFSDVTDV---TDVTDVPENEV-TE---APDIN-------
---------I-----V---------TEVTEVTD---L--------------CDVPNS-EV
IVVFENDDILR--AKQEEKEKMENILKPGCLRDTK-SKNEFKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-VTLTFQGERCFRTTLTEEESETSSS---K----
--GLS-ARTSEIKITDFKNTALKFEESR--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------PL-------L----LLPDV--------M
LLTCRATSCHDHVG--------RGQA----TKGRGR--KATETLEL---TRLLPL-----
-VVR-ISVHDRQ--------KQQLRLKFA-GRSCF-------LQLCPP---LHARDLFS-
HWEELIHLPRPPGDSRSST---HAVP----LHDTR--ARV-----------------GGR
GGA------------------------------------SPA-LPLQGQGAQD--QVSLR
SLHTAGVS-GASSPLVP-------------------------------------------
-----------------------GGRGSNMPPKPT-T---KPDTA-K-----PTRP---A
TGAAA------------------------------GAVAG-AVRVAGAVRVAD--T----
--------------------E-------------------------HSTAVA---G----
--AAAKGPG----DS---------------------------------------NSSLAV
AGV--ADVP------WKNIKVAVAGAASQTPERTASA---AGSTALC-RA-QLSVALGRS
SGH-QPGAGTAQD-SA-------------VGPPEDRKTQQEARKERRER-RERRDKDRAP
SRT---------------G--SR----RH-----SAG---------------------DS
RSTSGSRK-GA--------SRRSP-RE--------------------ERK--ERGRGSPG
-RSRRSSAHEGVRTPSPRAPD--------GSRSGRSPSRVSAS-----CTCE--------
-QLGRSSSFLRRERQST---AST----------SLSRNVD---LLPKRVE-RSSVEAILE
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MTMKSEFLLPY-YTAKNG--SGMSMFN----TAMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGVACTSPVLPL----PDV--------M
LLAHPAPGC-EELTRR-------GQA----TKGKSH--KAAKTLEL---TRLLPL-----
KFVR-ISVHNHG--------QQQLRLKFATGRSCY-------LQLCPP---AEAREDLFA
YWERLIYLLRPPVESTSST---YAIP----AEDTM--CMPVLDEDRM-S-------L-A-
------------------------------------------------------------
------------LTDP------------QGRED---SDQV-SVKS---FH-LD-ADVNRV
GSA-AF---------TGGEEIPHGTHKSTASVSVP--ITKSAELA-KN-VAAG-------
------------------------------------------------------------
---------------T-------------------TVEATAT--GGVAGALS-VTVT---
--K-SADSG-EVSA-AIAGA-------------------------AAT-GAAGGRGRVAI
AGT-------GKM-SPQGTNITLAGAASKSKEYV---S--HTATSLSSED-NTKAAIARV
GP-LSKSAGETAP--FPA--------------PLMSALPSASFLGGEAE-QQTRSRG---
SSR------AHKDK--RERREKDRAVGR-SSHHARAG---------------------EG
HRKRGREKMGRKSPSRR-DTGNV---K--------------------N------------
----KG-SPRDSAGHIPIAKEPWS-----AYKWGRSFANASSS-----STSK--------
-RLGRISSFLRNIRANLVAKGLA---------SQRIR---DMDIMAKTVE-TTNMEAIVE
TAESGQGLE-IV-GSVTSEV-------------METMTFDA-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEGQCMLPY-YTAESS--PAMGMFN----TSMGKL
QWQLYKG-KYT-IFRY-----APMFER------DFI--Q---------------------
-IS------------K-TGEVIDVHNRARMVTVAIVRTSPCLTL----PDV--------M
LLARPAVVC--DNARC-------GLA----TQERGS--PPAQLLEL---TRLLPL-----
MFVK-ISIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----VGNTS--DSSRSPMVSVYL-------AGL-
TF----------------------------------------------------------
------------FAIC------------SLPR----PYAM-KISR---LH-MN-AEMSGP
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MGPPLWPDLQEPPPPGTSSQ----------I-RSPLLCDVIKPAP
HHDVTVRVVPPPRFLPLLLRPLPS-DGDIAMRRDRGP-------KPAL------------
---------------GGAGEVEPGGMA------------------A-SP----TGRPRRL
QRYLQSG-EFD-QFRD-----FPIFES------NFV--QFCPDIYPAPT------SDLWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLEVKLNTSRTFY-------LQLRAP---LKTRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
SAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKK-------NKMEAD--EQEPLWIPQ-SHGLGHL
KNILDGG-EYS-PFIS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPIL----KTPNM--------M
LLAHLTPEARKE-----------SDPI---FKSLLTP-SSTENLVL---TRFLPL-----
QFVT-LSVHSAK--------NMRLKVKLISGRAYY-------LQLCAP---VYKQDIIFS
QWVDLIALLTQEKARTS--KVSEVSS-LSEITNST--DITDSMDIMEMT-----AFSEIR
AMHPHARIYSANINQSADFSEFTDVTDITDVTDVTDIPEYQA-TD---VPDIK-------
---------I-----V---------TEVTEVIE----------------E-KDDTNISGV
TVVFENDDILK--AKQEEKE---NVMKHGCLRNMN-SKNEFRE-----------------
---------SP--------------------------------------------K----
--------------------HVTISD-LTITFQGEKCFQTSLAPIKSEGNIC---K----
--VMD-DETREEKMTDLPKAGLKATVSRSTNTDSDTSDGE-MK-----------------
----LGRYLLKQSS-REKSF--------------------TYSLGSQHRG-FVFLYL---
----------TLQ-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLSPEV-REPC--SGVEL-----GVENGLL
CQLIRSP-EFN-LFSN-----SMVFES------NFI--Q---------------------
-V------------TK-PGKWMNASEDSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGE-------------------CSTWNTP-GVGPVITL---SRILPL-----
RYVE-LQICDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWIRLVKILRKGLSITTKD---PRIR----FTHCLVPKLTGLSTET--TP-ESSLPGSTQ
PSETL--LLLAAEQTSGSFSKLSG------------------------------------
--------------RTQF----------------------TADRSTK-------TAIKID
SSSS--------------------CNKTPSPVASP--VS----------VNIPMRATLSH
SLWEQDDPH-DHLL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSESLLPY-YTAQSY--RSMGVFN----TSMGDL
QRQLFKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKIC-EEHARQ-------GRL----AKGRGR--KPAKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVDSFSSA---PTVQ----NTDTT--------GDSRSL-------G---
------------------------------------------------------------
------------AAEL------------HGEGD---QKEV----R---LH-KT-REVSAA
NSS-AY---------AGGEGIQHASRGMAGAA----------------------------
------------------------------------------------------------
----------------------------AGTASGMAIAGVATSP--ATGAVS-IAT----
-TK-SAGSG-QVTA-ALVGA-------------------------ATK-NQEESESSKTV
AGA-------ANI-SSDGINLALVGITSTSSAGTS--NRTAGAASLSQDS-SSSLVFAGT
MT-TGAS---------AAV------------GPLVSTLQSEGYMSERDG-SQKVSQPCAE
AQK------EKKER--RQKKDRNP--SRKSSHHHRKG---------------------GE
KT--------RKASSHRSSSSPRNTRD--------------------DKK--GKAHSHRR
-SKRHG-PSRKSSSHTSARKESRT-----AHKLGKSRSAASSG-----TLSK--------
-KASKISSFLRSLRPSPGSKAVA---------PPQDT---EVDIMTKTVE-KCNIEAKVD
KAQDGKELEVIS-SSMTSET-------------MEMIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSIPHRNT-WWKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDREQN--PGVTL-----GVEEGLL
CQLLHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWIDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHRGQ-------------------SQTWNRP-STAPNIIL---KRILPL-----
KFVE-LQVCDRL--------QRILRLRTVTEKIYY-------LKLHPN-----HPATVFH
FWIRLVQILQKGLSITTKD---PRIL----VSHCLVPKNCCSPSGD-SKL-VQKKPQASQ
PSESL--IRLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQFSFRSSKKM-------ETKKD
SSVK--------------------DTSREDEDSIP--CT----------RDLSWRESFTY
GEWERENPS-GPQP--------------LSLLSTLAASTRPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSVPHRKT-WRKSK---KTVQV
TRSFPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWIDINKAPNTVALGVTSSVPCLPL----PNV--------L
LMARVKWHPGQ-------------------SQTWNRP-SKAPKIIL---RRILPL-----
KFVE-LQVCDRL--------QRILRLRTVTEKIYY-------LKLHPD-----HPKTVFH
FWIRLIQILQTGLSITTKD---PRIL----VTHCLVPKNCYSPSGN-SKL-VQKKPQASH
PSESL--LQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------RNQFRSCKKMKIHK----------
-ICT--------------------EKYTAREDSIP--CT----------RDLSWRESFTC
GEWERENPS-GPQP--------------LSLLSTLAASTWPQ------------------
----------------------------LAPSIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAI-RDPG--PGVEL-----GVVDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNI--------L
LMANVTWPHGP-------------------FSTHSA--LGAPVITL---SRILPL-----
KYVE-LQIYDRT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMFNSSTET--TT-ESSLPTSSQ
NSEAI--MLLAAEQNSSSLLELSN------------------------------------
--------------RHQL----------------------SGDRNT---------ATETD
NSG---------------------NCKTTPLVASS--------------TSMPMRAALTH
SLWEQEDSC-ENFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MSAKNESLLPY-YTAQSG--SGVGMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAPGC-EEFPGR-------GQT----TKGKNR--KAGKTLEL---TRLLPL-----
KFVR-ISVHNRE--------KQQLRLKFATGRSCY-------LQLCPP---LEGRDDLFI
YWEKLIYLLRPPVDSNSST---YAIP----AEDMV--CMPLLEEEEKNS-------A-T-
------------------------------------------------------------
------------AVEP------------QGKGE---PDQV-SVRS---LP-MA-TDVNGV
SSA-AF---------AGGEGIHHDSYRSSPVPSASTPKAKPKDLT-KE-PA---------
------------------------------------------------------------
----------------------------------------AV--GGLAGALS-LAAA---
--R-SVGPG-QKNA-ALAGS-------------------------AVM-GARGSKSHLAI
ASA-------GKM-SPKSMKAALAGTASRSLEYI---S--STSTSLSRKD-SLTVAIAGI
EP-TSKSVGEAAA--DPA---------------PAALALSESHTDGQTG-EQRAPEGSTE
ANK------ERRER--RERRAKDRAGS-RSSRRQRTG---------------------ES
RRKTAGDKAVRKPASRR-STR--AAAE--------------------K-----K----EK
-GSKHG-RSHKGVSHVPITKESRS-----SHKSGRTLSTSSSA-----SANK--------
-RVGRISLFLRNIRANLAAKGLA---------SQRGQ---DMDIVAKTLE-TTDVEAIME
T-ENGQGLD-II-GSVTSEV-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSQSTLPH-YTAESS--LAVGVFN----TSMGKL
QRQLYQR-EYT-IFQY-----APVFEN------GFI--Q---------------------
-VS------------R-KGEMIDVHNRARLATLGIIHTSPYLTL----PSV--------M
LLARSGTIC-DYYNRH-------SPA----AQDR----------EI---TRLLPL-----
KFIK-ISLRNRE--------KQQLHLKLATGQIFL------------------------L
TWENLSYILRPLVEHNKGT---QAIP----AGDTL--DTLGLRKTISV------------
------------------------------------------------------------
---------------Q------------WC------LYQA-SIRS---LH-IN-PEVFRA
TDQ-DY---------AGEE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSNDRVLPY-YTAHSY--RSMGVFN----TSMGTL
QRQLHKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVTDVHNRVRMVTVCIASTSPVLPL----PDV--------L
LLARPTKIG-EDHARR-------AWL----IKGRGLL-KPSKTLEL---TRLLPL-----
KFVK-ISVHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPMESCSSS---PTLD----TGDAKI-S-----EDSKSL-------L---
------------------------------------------------------------
------------ASQD------------QGEGD---QES-----G---HQ-KL-RDVSGA
TSA-AF---------AGGEGTKQGTSVFAATRT---------------------------
P---------GSAKVGAAGAAG-----------------GT-------------------
-------------AVAAVTTGSLAGAAGTAATAGVAKPGTATSS--ASGAVS-MAA----
-TK-SPGSA-RVAT-ALAGT-------------------------ATK-NQGRGGSNKVI
AAA-------ANI-SCEGVDVVLAGAASTSSEVSS----GGGVVTTSQES-TVSVVFAGT
MT-TEGPAAEK--EDPLVM------------APLVSTLQSEGYMCERDG-SQRVSQTTPE
LQK------EKRER--RE-KDRNA--SRKSSHHRTAGAN---------------------
QHSTSRDK-NRKSSSHRSVSGHGKARE--------------------DKK--GKGQSSLR
-GKRHGS-AHKS--------QSRT-----AHKPRKSRSGASSE-----SMGK--------
-HSSKIGSFLRSFLIRPTSKAWV---------TSRDR--KGLDIVAKKVE-KHNMETKVE
KG---KDLE-IM-STVTSET-------------TERIIYEAKS-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MRPPLYPGVPEPP-----------------L-QRPLLCDVIQPTP
F-------------------------GDIAMRRERGP-------KPAL------------
---------------GGAGEAELGGMA------------------EFSP----TGRPRQL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q-------FCPHIH--------
PVT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RRQLKVKLSNHRAFY-------LQLQAP---PETRDREFG
QWVR--------------------------LLYRL--RFR-----------------SA-
PAVPFTRE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTPHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGRGR--KPSKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPTDSCSI----PILP----TGDT--------------------------
------------------------------------------------------------
------------GSDI------------HGEGD---QDS-----G---RQ-KL-RDVSGA
TSA-AY---------AGGEGIQPAIPASVAIGS---------------------------
R---------GPAKGVAAGASV-----------------GT-------------------
-------------VAAGITTG---------PSAGVAKVGTATCP--PSGAIS-MAA----
-NK-SPGSG-QIVT-SLAGT-------------------------ASS-DSGGCGSSKNL
AAV-------VNI-STEVIDVVLAGAASSSSECTS----TGGAASVNPDS-NLNVAFAGT
MT-TKGPAADK--PE----------------APLVSTLQSEGYMCERDG-SQKVSHTGSE
PRK------EKRER--PEKKDRNA--SRKGSHHRRTGAS---------------------
HRSSGKEK-PRKSSSHRSVSGHGKTRE--------------------DKK--GKRQSSIR
-GKRRSS-SHKS--------ESRT-----AHKPRKNRSSASSX-----X--X--------
-XXXKISSFLRSFIIRPTSKPGA---------NSCDM--GGVDIVTKTVE-KHNLEAKME
KG---SELE-FS-GIVT-ET-------------TERIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDALCTPH-SHDPGHL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGTQKD-----------TESL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAS---ACKQDTLFS
QWVALIYLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMNVMDIT-----AFTAIP
IPYMHAGTGPVHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVTEVRE---ATEV-------TDS-LDVTKCSGV
TVMFENNDLIR--AKQEEKEKMKDILKPGCLQDTK-SKSELKE-----------------
---------SP--------------------------------------------K----
--------------------HVTISN-LTVTFEDKGYFQTTLTPVESEANTS---K----
--EME-DKTSEEKMSDFKSTALKAEESRSLRTESNTSVL---SPHIKS------------
SSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGKGC--KPSKTLEL---TRLLPL-----
KFVK-ISVHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPMTNCISN---STLP----TGETSV-D-------TKST-------L---
------------------------------------------------------------
------------VSEI------------RGEGD---QNS-----R---PQ-SS-PTVSEA
TSA-AF---------AGGERTQPAAAAAVTPVSAKARAAGTAGAA-AG-TAGA--AAGT-
A---------G-----------AAAGTAGATAGTAGATAGTAGATAGTAGATAGMAGATA
GTAAETAGTAAGTAGAVKAAGGPMAAAVTAPSAGMTKAETATSP--TSGVIS-LAAT---
TTK-PPGSG-QVAA-AMIGS-------------------------AAK-DQVGGESSKAM
ALA-------ANI-TLENVDVALAGAANSISESPP----AGGDASGSPDT-GLNVAFAGS
IK-TKAPAEDK--PE----------------APLVSTLQSEGYMCERDG-SQKVSQTSSE
AKK------EKRER--RE-KDRTS--SRKSSHHRRTGTS---------------------
RHS-SKEK-SRKTSSYRSVSG--KTRE--------------------D-K--GKGHGRLR
-GKRHSS-SHKS--------ESRT-----GHKTRKNRSPAGLG-----SVSK--------
-RATKITSFFRSFLIRPTPKAGD---------TSCDR--GGVDIVTKLVEKKQDIEAVME
KS---KDLE-FK-DTVISET-------------MEKIILETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHGKT-WRKSK---NTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDREPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPRNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKAENEALSQIFA------------------------------------
--------------DLHQ------------------QNQL--RSSKKV-------ETNKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSAPPRKS-WWTSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGETN--PGVGL-----GVEEGLL
CQMLHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRNWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWRQGQ-------------------SQTWNKP-SRAPSINL---KSILPL-----
KFVE-LQIWDDQ--------ERILRLRTVTEKIYY-------LKLHPD-----HPETVFR
FWTRLVQILQKGLSITTKD---PTIL----VTHCLVPKSLCSPGGK-TEL-VQKKSEGLQ
PSESL--THLMAQGESEALSQIFS------------------------------------
--------------DLHQ------------------QKQYSSSRSKKVQI--N-------
KTSS--------------------EKATPCEDSIP--CT----------CDLNWRDAFMF
GEWERENPS-GPQT--------------LSLLSTLAASSRPR------------------
----------------------------LSLTGGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSQFKLPH-YTAQSS--PAMGMFN----TSMGKL
QQQLYKG-EYS-IFKY-----APMFES------DFI--Q---------------------
-VS------------K-KGEVIDVHNRARMVTVGIVRTSPHFTL----PDV--------M
LLARPAAMC-DDYNRY-------GPA----TLEKGY--KPTQILEL---TRLLPL-----
KFVT-ISIHNGK--------KQQLHLKLATGRSFY-------LQLCPP---SNT-RDLFV
HWENLVYILRPPVEAYSGS---QAIP----IGNTL--DITGFEEKNKSP-------GA--
------------------------------------------------------------
------------NVIH------------VYGRD---QDQV-GIKT---LH-MN-PTVFGT
TYY-GY---------AGEE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MMKKTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVS-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYTRTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PG---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFECKRYFQTTMTPVESEANTS---K----
--EME-NKTSEEKTPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVLHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MTGQSGLPD-YTAGNS--PATG-FN----MPMGKL
QRQLYKG-EYN-MFKY-----APMFES------DFM--Q---------------------
-VN------------R-RGKIVDVHKRSQMVTVAIVRTSPSLTL----PDV--------M
LLAQPSTVP---SASC-------GPA----TRDKRC--KPTEASEL---TRMFPF-----
KFVK-ISIHNAV--------KQQIRLKLVTGRSFY-------LQLCSP---SNT-KDLFV
HWENLVYLLKPPVESYSGT---EARL----AGKTI--GSHVSFQEYRSV-------VA--
------------------------------------------------------------
------------YAMK------------FCGK----KDKF-SIGR---FD-MR-LATYGP
TYF-AD---------ERET-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MMKKTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FQSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDTE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYTRTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKK-----IENILKPG--------KSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKTPDFQSMALKAEESRYVRQEHAKGIL---RHEILI------------
KKCVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------TMGHKSKLA---L-------GAVGRL--LDPACS----LEGPGWL
QRHLLSG-EFD-QLRD-----FSIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGP-KEDR----------------------------C----LQL---LGLFPL-----
QFVE-LFVHDAS--------RQQLKVKLCTGRAFY-------LQLRAP---AKTRDLEFG
QWVR--------------------------LLYRL--RFH-----------------AGQ
GAVPFTQEEW-------GDE---EGDEE---TDGDLEERERD-WR--D------------
--------------------------------------Q----VS---------------
------------RA----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKP-WWNSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------LLGASEQP--------ALL---------------------------
----------------------------------------GVFFCI---LRILPL-----
KFVE-LQICDHH--------ERILRLRTVTEKIYF-------LKLHPD-----HPETVFL
FWIRLVQILQKGLSITTKD---PSIL----VTHCLVPKSLCNPCGK-SGV-RNLLLPAFR
FELLL--SGILLNLELEGFLL---------------------------------------
--------------G---------------------------------------------
------------------------------------------------------------
--WGQQAP--------------------TVLLSLLLNSSPPV------------------
----------------------------LGLEVCTAV-DGSLCGC---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRNVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GEAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSTET--TP-ENSLLSSPQ
PSKSL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KPQP----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPIRAVLSH
SFWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MGLPLWPDLQEPPPPGTSSQ----------T-RSPLLCDVIKPAP
HHDVTVRVLPSPRFLRLLLRPLPS-DGDIAMRRDRGP-------KPAL------------
---------------DGAGEVEPGGMA------------------A-SP----TGRPRRL
QRYLQSG-EFD-QFRD-----FPIFES------NFV--QFCPHIYPAPT------SDLWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLEVKLNTSRTFY-------LQLRAP---LKTRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
STVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARI----IKGKGC--KPSKTLEL---TRLLPL-----
KFVK-ISVHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPMTNCISN---STLP----TGETSV-D-------TKST-------L---
------------------------------------------------------------
------------VSEI------------RGEGD---QNS-----R---PQ-SS-PTLSEA
TSA-AF---------AGGERTQPAAAAAVTPVSAKARAAGVAGAA-AG-TAGA--T----
-------------------------------AGTAGATTGTAGATAGTAGVTAGMAGATA
GTAAETAGTAAGTAGAARAAGGPMAAAVTAPSAGMTKAETATSP--TSGVIS-LAAA---
TTK-PPGSG-QVAA-AMVGS-------------------------AAK-DQVGGESSKAM
ALV-------ANI-TLESVDVALAGAANSISESPP----AGGDASGSPDT-GLNVAFAGS
IK-TKGPAEKK--PE----------------APLVSTLQSEGYMCERDG-SQKVSQTSSE
TKK------EKRER--RE-KDRTS--SRKSSHHRRTGTS---------------------
RHG-SKDK-SRKAPSFRSVSG--KTRE--------------------D-K--GKGHGRLR
-GKRHSS-SHKS--------ESRT-----GHKTRKNRSPAGMG-----SVSK--------
-RATKITSFFRSFLIRPTPKAGD---------TSCDR--GGVDIVTKLVEKKQDIEAVME
KS---KDLE-FN-DTVISET-------------MEKIILETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKNTTS--K-STMRIN--KQDALCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-SG-------------------------------------ST----HIPNV--------M
LLAHWTPGALQ------------NFPL---FKGLLTS-PPEHKLVI---IQFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSTDVMDIT-----AFTAIL
TPYMYAGTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITDCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQGTK-S-----------------------
------------------------------------------------------------
----------------------------------KRYFQTTLTPVESEANTS---K----
--EME-DKTSEEKMPDFQSTALKAEESRSLRTESNTSVL---SLHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNKIRGLPPAV-RDPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYEKSATMIIGVTSSVPSLPL----PNV--------L
LMANVTWPHGP-------------------FSTSST--PGAPVITL---SRILPL-----
KYVE-LQIYDYT--------KRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKIPNPSIKT--TP-ESSVPASSQ
PSENG--MLLAAERTNGSLLGLSK------------------------------------
--------------RHQL----------------------TGDRSTE-------TTIEIN
SSS---------------------SCKTPPLVASS--------------VNMPMRATLTH
SLWEQENPN-ESFL-----------------QVPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRNSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------NQTWNRP-STAPNIFL---KRILPL-----
KLVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSLSGD-LKL-VQKKLQASQ
PSESL--IQLMTKGESEVLSQIFA------------------------------------
--------------DLHQ------------------QNQL--RRSKKV-------ETNKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALAFS-FRA----
-G--S-DPE--VLR-----VIPESCGVWS--RNAGHRDLSP-LFPTGLSKTVMCGTSRAP
RVP--------------PDAVDAIAAFSCCIGGV------RDRLCRLPMWSFLSFPFLEL
L-----------K----------------------------SLLTAWIG-MQRVKRK---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKR--LLNI-RRTQPP--QDPQKW----VPILGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGAPAFVHHRTNKLTMGVAASLPGL----VLPDI--------L
LLARPPE--G----------------------------KDCPNLNL---TRMIPL-----
DLAH-LYVHDLP--------SWRLKLRLITGRYYY-------LELDAP---DHELDFLFD
RWIRLINLLHEPTISWAPR---TMNT----P--PL--DAP-----------------LD-
------------------------------------GAPAST-WLE--------------
VAQRTIPHKI--FSSQKQRKTK-----------TVKR-TLRSQAV-------------GD
SLPLIWSQLKPPEDQMKVTEK--KSYLNACHDRSK-TLIRVS------------------
------------------------------------------------------------
--------------------------------------------EKASITIR---T----
--IFSIISG----MMNQ--------ESD-----SEGTTGRGGL----IETPTQCIAHDSP
GLPIIDSCDHMDTFLWTQDLD-----ELMDTESTSLSS-SLYTSPYPPAL-YI-------
----------FPK-SND------------KAMPVGSVKYMGP-----LS-SQKAASAPIP
PGK------APFIL---DQ--STKVPAE--------------------------------
----------P------APAQKAPALPAPARK----------TPAAPWST--QKSPAKPS
-LFYKVPPS--ISQKPPSIPAPPRKAPVLVAPPQKTLPPIPKL-LQVPAGPQKA------
TPPKKELLVLNTQSRKA-PTARYQ-----KTPDSRAKAPEDTSVL----PAG----DML-
ERKSEGKQQPVV---L------------VRGQKTKVVDMRAQATALQLPSA--TTKKQSK
EILISKTQ----EALTCRGKSEDRAHKMR-EETTVNLPDLKSKEIEKQKKWVLTQEVAVE
GLHTENNRAFSVEGLALAKMMIVAKS---KQQ-HLKPD-TISLPSWFSMTSRGSAMSTLA
--DFPFNASQMALSEDTQVVVRS----PTKVKENTQLQVEE-KPPEDLLRTSKE------
---TIIELPKTDSPKVGKTAQFPTTMTTSGLENTSRPMTPLTSLTSPITKTDSSVGVPQK
PGVKH----------------------------------------QGLKQAQTQQQPLAV
LGSTSEVLLPIVLEMENKKKMSMKEEILVKE---FGTPH-AQVFDISSWHPLSTLIYICI
QRERERER----ERERE-------EEEEEEREGGEESRFSRLNSVHCVC

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKNK------SSVNKQ--AQDALCISQ-SHNLGHL
KNILDGG-EYA-PFVS-----PPVLES------NFL--Q---------------------
-VS------------R-RGESIYLHNRANWVTVGICSSCPTL----KIPNV--------M
LLAHMTPAVYKN-----------TEPL---FTTLLKS-PSPEKLVL---TRFLPL-----
QFVT-LSVHDAK--------HMRLKVKLVSGRAYY-------LQLCAP---MYKQDDIFS
QWVNLISCLSQEKAKAS--KVSEVSS-LSKITNST--DITDSMDIMDIA-----AFEEIQ
TIQDHTHIYSSNIGESTDFSKFTDVTDITDVTDVTDIPENEV-TK---VPDIN-------
---------I-----F---------TEVTEVIEVLEAT--------------GVPDPSGV
TVIFENDDIIR--AKQEEKE---YVLKHGCLRDSK-NKNEFRE-----------------
---------TP--------------------------------------------K----
--------------------HVTISN-ITLTFQNERCFQTTLTPIKSGEIIP---E----
--ESI-DKTSKENMTDFQNTALKATESRYVEQKQYKKDYS------VNPTFRLCIH----
------LLLYC-CD---KTL----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MTDIRGLPPIMVGEPD--PGVAL-----GVEEGLL
CQLLHSP-EFN-LFPN-----SAVFES------NFI--Q---------------------
-V-----------RKT-NDWWVDTEDWSTTVVLGVTSSVPCLPL----PNI--------F
LMAKITWPQGH-------------------LSTWNKS-INAPTVTL---SRILPM-----
KFVE-LMVYDKS--------QRILRVRTVTEKIYY-------MKLHPK-----HPTAVFH
FWIRLVNILQKGLSITSKD---PSIH----VNHCLVPKTPSTIILE--ES-TEYDPSDSQ
ARERL--MLLMAPQGHEAFSDLSL------------------------------------
--------------DLTT----------------------KQDQLKTC--PTNNQTTKIS
KAE----------------------------IEEE--AK----------YNSDLTFLLMC
ECMNQ-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNDQFMLPY-YTAQSS--PAMGMFN----TPMGKL
QRQLYKG-EYA-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGDLIDVHNRARMVTVGIVRTSPGLTL----PDV--------M
LLAQPAATNGDNSARC-------GPA----TQKRGS--KPTQILEL---TRLFPL-----
KFVK-ITIHNSI--------KQQLRLKLITGRSFY-------LQLCSP---SDT-RDLFV
HWENLIYILRPPMEAYSGP---QAML----DGNTL---SYVFEEEHPSP-------VA--
------------------------------------------------------------
------------YAMK------------FCGR----KDQF-SIMR---LR-MS-TEVSGA
TYF-SY---------GRQT-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGPPTEV-REPG--PGMEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-THAPEAD---FQVTK-PGKWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FTTWSTP-GDAPVINL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSTET--TP-ENSLLSSPQ
PSESL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NWSS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSY
SLWEQEDQN-EHLL-----------------QVPIASSLG--------------------
----------------------------------EHLLGA--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNDWEEFRGL-LPVDREPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHHGQ-------------------NQTWNRP-SIAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-LQKKLQASQ
PSESL--IQLMTKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETSKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SRGMQV-------QKYYSP--PDSLAM----NLLTGEL
QKHLFNG-EYD-PFRQ-----TPIFES------DFI--Q---------------------
-VS------------K-KGQLIDIHNHLNVVTLGILATCPTM----SLPNI--------M
LLAKPLCIPNIMK---------CPT--------PVF--IHRRQVEL---SRLFPL-----
KFVK-LSVKDRE--------KCQIKMRLANGRTFY-------LQLYAS---PEIEKEMFE
KWERLISMLRPSSEDTVTM---RRAS----VATST--VLQ-----------------VVQ
TAP---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNNK--K-L---TD--EQDALCVPQ-SQDPGYL
QNMLDKG-EYD-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTQ----KTPNV--------M
LLAHLTPAAQKDTE--------DTEPL---FESLLTC-PSTEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---ADKQDTLFS
QWMDLISLLNQEKAKAS--KVSEVSS-LSEITNST--EITESMDIMDIT-----AFSAVS
SPHMYSYTDAIQVTESIDFSEFTDVTDV---TDVTDVPENVI-PE---VPDIR-------
---------I-----V---------TEVTEVTD---N--------------FDVTNFSGV
TVVFENDDIIK--AKQEEKEKTENVLKPGCLRDTK-SRNEFKE-----------------
---------SS--------------------------------------------K----
--------------------RVTISN-ITLTFQGERCFQTTLTPLESEANTS---K----
--EVY-DKTSSKKMTNFKSRALKFVESRNVKTDSDTSGG---WI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNGDSLLPY-YTAQSG--SSMSMFN----TTMGRL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GQA----NKRKKR--KAAKNLEL---TRLLPL-----
KFVR-ISVHDHE--------KQQLRLKFATGRSCY-------LQLCPA---LNTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WMPVFQEDRR-S-------L-E-
------------------------------------------------------------
------------AVDL------------QGKGD---QDQV-SIRS---LH-MV-SEVCGA
TSA-AY---------AGGERLQHDFHKPTNVLNVSIPETFTE-LA-EE-P-AT-------
------------------------------------------------------------
---------------G-ATKEAAAAG---------AAAGAAT--GTIAGALS-VAAA---
--N-SA-PG-QVSA-AIAGV-------------------------ATI-GAGGSKSNMAI
AGA-------ASM-APNSTKVAVAGAAGKSSEHV---S--STSMSLSREG-SVSLAIAGV
EL-TSRTAAETDM--DAAA------------GLPVSTRQSKGSLSGQHGR--EQTQASAE
ACK------EG-----RERREKDRALGR-SSHRCRTG---------------------ES
HHKTRGDKIARKSSSRS-SFSHRASRD--------------------DKK--EKGCGSLG
-SSRHG-DSHKGVSHTPISKESRT-----SHKSGRSLSTTGSE-----S-SK--------
-RLGRISSFLRNVRANLTTKAVG---------IPHGR---DVDIMAKTVE-RSTNVAIAK
TAEGGQGLE-MV-GSMTPDI-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEVGFLFH
CWVRLINLLQEPAPTCTPR---ATRT----A--PL--DMP-----------------LA-
------------------------------------EAPAST-WHLQDQPISR---HAVR
VAEHNFPRKT--VAAQRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHSDPRPDRTH-TQIR---L----------------
------------------------------------------------------------
-------------------------------------------PEKTSITTW---T----
--IFSIISS----TANQTQSSPKACTSA-----CDEATGQGHV----VESPSHCVSADRP
DGFFLGSCSSLDPCLWHQDTE-----DLMDSEGSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KARPMGSHQGPGP-----PP-CQKAPSGPVT
SCK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPS--Q-------
----KAPAIPAPTWKASAASASPRKASALPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKKKSLLLPAPSQKALPTSPTQYQMALGPPASRGKLPGDFDVL----PTGIPGRAVLE
RSQSGGKPEPAV---T------------VRTQETDVVEMTTQAKSPESPFT--VTQKESK
DILISQTEEVTPEAFRGQGKLEDRAHWVKLEERSRDLPGVRSKEMEQRKRWVKAKELAVE
GPSQEHSRPFSVEALTLAKLMITANS---KEQ-RSKPA-VVSLPSWLLATPQASATSMMA
--SVPSRPGQLSSLEGKPVVVREQPESHTWVKEGKRPWG--------EMKEPPWDPEGP-
PKVPFRSKPTSASLKREGISQAPIPLTASPWEDL--RPSP--LSETPISKMEATARASQQ
PKRVSQEPV-----------------------------------------RMPAQHPLAT
VGSSSEILLPILLELETVRNTATKAEEIQEESGVLNLLPSLQHSQHSEWPDAGA------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSIET--TP-ENSLLSSPQ
PSESL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KLQL----------------------TADRNND-------TAIEID
NRSS--------------------Y-KIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPE-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MGLRRGRGQ-------RREK------------
---------------------DPSPRTW-------QAFSHS--PPVALG----APGPGHL
QRCLLDG-EYD-QLCD-----FPIYET------NFV--Q---------------------
-VT------------R-SGE------VANKVTMGVAASTPAL----ELPDV--------L
LLARPRSGPG----------------------------CSDQELQL---FEMIPL-----
QFVQ-LFVHSEG--------RRQLKIKLGSGRTFY-------LQ-----------NREFG
CWVR--------------------------LLFRL--RFP-----------------AGG
DGPPFTQALT-------LED---DRDEE---ASGGAGAGAGE------------------
------------------------------------------GQD---------------
------------EERPCPS---------------------------------------MG
EVQGA-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MDSDRESAD-PSTQSC--PVLPMFH----SSVGKL
HQLLGKG-EYT-LLKD-----VPTFES------DFI--Q---------------------
-VN------------R-RGEVIDVHNTVNMVTIGVAYTGQHLPG----PDV--------M
LLAQPATHC-VASASD-------DSD----TQRTDF--KASESLEL---TRLLPL-----
KFVK-LSIYNHD--------KKQFQLKLATGRSFY-------LQLCPP---SNSKEDVFA
CWEDLVGLLRPPMEAYSGT---QAQP----AGDMV--SIPGLEAEDRRS-------P---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPHRKT-WNKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDGEPN--PGVGL-----GVEEGLL
GQMVHSP-EFN-LFPE-----SVVFES------NFV--Q---------------------
-V------------RK-GRNWIDIYKACNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHHGQ-------------------NQTWNKP-STAPKIIL---KRILPL-----
KFVE-LQVSDRL--------QRVLRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLIQILQKGLSITTKD---PRIL----VTHCLVPKSSCSPSGD-SQL-VQKKPQASQ
PSESL--MQLMAKGESEALCQIFA------------------------------------
--------------DLHQ------------------HHLFSSRSSRK-------TENKKD
SS-G--------------------KKTSLSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQS--------------LSLLSTLAASTGPQ------------------
----------------------------LAPLIGSSI-HPCIHLTFI-------KY----
-F--L-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------GLPLLCDVIKPTP
LCDVTVPVAPHPRFVPRLLPPLQSRCGDIAMKRERGP-------KPAF------------
---------------GGAGEAELGGMA------------------A-SP----TGLPRGL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--S-------APTSILPLTSHLWP
QVT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKLSNHRTFY-------LQLQAP---PKTREREFG
QWVR--------------------------LLYRL--HFQ-----------------SA-
PAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--SSMSAFK----TSMGDL
QRQLYNRGEYN-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLAQPTKIC-EQHVRW-------GRF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----SGDAPP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGTASAASPSTSTPGAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGTATGPRTDVAIAGAAMSP--ATGAMS-IAT----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSEGISLALVGAASTSLEGTS--TSMAGAASLSQDS-SLSAAFAGS
IT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSQPSAE
VWN------ENKER--REKKDRHP--SRKSSHHRKAG---------------------ES
HRRRAGDK-NQKASSHRSASGHKNTRD--------------------DKK--EKGYSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----TQELGKNQSASSTG-----ALQK--------
-KASKISSFLRSLRATPGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTMTSEK-------------TEMIVFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------VMTSVPPRKS-WWKSK---KTVKV
IRSYPTFP-------------SLNTWEKFRGL-LPVDVEPN--PGVDL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWIEIYKATKTMALGVTASVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-SAAPSIIL---KRILPL-----
KFVE-LQICDHH--------DRILQLRTVTEKIYY-------LKLHPD-----HPETVFQ
LWMRLVQILQKGLSITTKD---PTIL----VTHCLVPKCLHSPGGK-SEL-VLKKPQGPQ
PSESL--MQLVVKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQFSSRRSKKMEI--N-------
KSSS--------------------EKATPPEDSIP--CT----------CDLSWRDELTY
GEWERENPS-GPQP--------------LSLLGTLAASSRPQ------------------
----------------------------LSLHRGMNEIDCRA------------------
-G----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGSRKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKTPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------PL-------L----PLPDV--------M
LPTCRATSCQDHVG--------RGQA----TKGRGR--KAAETLEL---TRLLPL-----
-KVR-ISVHNQQ--------KQQLRLKFAPGRSCF-------LQLCPP---LHARETSF-
PLEKLIHLLRPLGDGRSST---HAVP----AGDMT--GAP-----------------GLE
EEA------------------------------------GPA-LPLQGQGGQD--QVSLR
SLLTASGVSGASSPLMP-------------------------------------------
-----------------------GGRGSNMPPQTH-D---QARHR-Q-----THTSCHRG
CSWGR------------------------------GGGGG-KGAGAGAVRVAD--T----
--------------------E-------------------------HSTAVA---G----
--AAPKGPG----DS---------------------------------------NSSLAV
AGV--ADVP------WRNIKVAVAGAASQAPERTASA---AGSTALS-RA-QLSVALGRS
SGH-QPGAGTAQD-SA-------------AGPPEDRKTQQEARKERRER-RERRDKDRAP
SRT---------------G--SG----RH-----SAG---------------------DS
RSKSRSRK-GARSSGRSLSSRRSP-RE--------------------ERK--ERGRGSPG
-RSRRSSAHEGVTAR--------------GHQSGRSPSRVRAS-----CTCE--------
-RLGRSSSPLRRGKAPLGPSPPP----------SSSRNVD---LLPKRVE-RSSVEAILE
AA----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSGESLLPY-HTAQSA--SGAGMFH----TTMGKL
QRQLHKG-EYD-MFKH-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPATGC-DEHAGR-------NQA----TKSRSR--KAARTVEL---TRLLPL-----
KFVR-ISVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LDTREDLFA
YWEKLIYLLRPPVDSNSST---YAIP----AGDMI--CMPVPEEEDRRS-------L-A-
------------------------------------------------------------
------------AADF------------QGKGD---QDQV-SIRS---LH-VG-SEVAGA
TSA-AF---------AGGEGIQLNFHKPTAMPDAANTNVKPAELD-NE-ST-V-------
------------------------------------------------------------
---------------G-SVMEVEVAG---------VAAGTAE--GTGAGALS-MAVT---
--K-FTAPE-QQST-ATAAI-------------------------ATK-GPRGCKTNTAT
AGA-------AKT-SPRSMKMALAGAPNNLEYAS------STSTSLSPEA-SMTVA--GA
GL-TSKTVRGTAH--DEDE------------EPLISTLSQEDQMSEQDGRPQRAS----Q
PRK------GRRER--RERREKERARR--SSQPRRSA---------------------ES
RHKAGGDKIIRKAANRS-SAGRRATRD--------------------DKK--EKGRSSSA
-GSKRG-TAHKGISHAPITKESRT-----SHKSGRSLSTASSG-----SATK--------
-RLSRISSFLRNVRANLTTKTAA---------SARDK---DVDILAKAVE-RTRMEAIIE
SAESGQGLE-IA-GSVTSET-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKT-WWKSK---KTVKV
RRSYSTFP-------------SLNAWEKFRGL-LPVDGETN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRDWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVIWHQGQ-------------------SQTWNRP-STVPSINL---KSILPL-----
KFVE-LQIWDHH--------ERILRLRTVTEKIYF-------LKLHPD-----HPETVFR
FWIRLVQILHKGLSITTKD---PTIL----VTHCLVPKSLCSPGGK-SEL-VQKNSKGLQ
PSESL--THLMAQGESEALSQIFS------------------------------------
--------------DLHQ------------------QKQYSSSRSEKVQI--N-------
KTSS--------------------EKATPCEDSIP--CT----------CDLNWRDAFMF
GEWERENPS-GPQP--------------LSLLSTLAASSRPR------------------
----------------------------LSLIGGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MTMTSDSLLPY-YTAQSG--SGVGMFN----TAMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAPGC-EDFPGR-------SQT----TKGKSR--KAAKTLEL---TRLLPL-----
KFVR-ISVHNRE--------KQQLRLKFATGRSCY-------LQLCPP---LEGRDDLFA
YWEKLIYLLRPPVDSNSST---YAIP----AEDMV--CMPLLEEDDKTS-------I-A-
------------------------------------------------------------
------------AAEF------------QGKGD---PDQV-SVRS---LP-VV-TDVSGI
SSA-AF---------AGGEGIHHDSHKPTSLPSVSTPKANPKDLA-KE-PSTE-------
------------------------------------------------------------
------------------------------------TTAASV--GSLVGALS-LAGP---
--R-SVSSG-QTNA-DIAGG-------------------------AAM-GARGSKSHLAI
AST-------GKM-SPKSVKAALVGTASKSLEYI---S--SASSSVSRKD-SMTMAIVRL
EP-TSKSVEETAT--DPA---------------L--TLPSESHTTEQTR-QPKAPEANTE
ANK------ERRER--RERRAKDRAGSSRSSRQQRTG---------------------ES
RRKAAGEKVVRKSTSRR-SAR--ADKK--------------------EK---GT----LR
-GSKRN-RSHKGVSHVPITKESRS-----SHKSARTLSTASSA-----STSK--------
-RVGRISLFLRNIRANLAAKGLA---------SQRGQ---DTDIVAKTLE-TTNVEAIME
T-ESGQGLD-II-GSVTSEV-------------METVIFEAP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSIPHRKT--WKSK---KTVKV
TKSYPTFP-------------SLNAWEEFRGL-LPVDAELN--SGVAL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KK-GRNWINIYKVSKTMALGVTSSVPCLPL----PNI--------L
LMAS-----GQ-------------------SQTWNRP-AIAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QGILRLRTVTEKMYY-------LKLHPD-----HPQTVFH
FWIQVVQILKEGLSITTKD---PRIL----VTHCLVPKNNCSSSED-SKL-VQKKLQASQ
PSESL--MQLMAKRESEALSQIFE------------------------------------
--------------DLHQ------------------QKPFRSSK--KMN-----------
KACS--------------------EKDPPPKDDIP--CT----------HDFSWRESLTY
GEWERENPS-GPQP--------------LSLLSTLAASTWPR------------------
----------------------------LAPPIGTSR-GPIRLP-EDSLEFH-LRA----
-G--S-GLE--VLK-----VMPECSGLGV--G----------------------------
------------------KAVTLSVFLPCSLIHQ------G-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPQRKT-WNKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDGEPN--PGVGL-----GVEEGLL
CQMVHSP-EFS-LFPE-----SVMFES------NFV--Q---------------------
-V------------KK-GRSWVDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-SAAPKIIL---KRILPL-----
KFVE-LQVCDRL--------QRVLRLRTVMEKIYY-------LRLHPD-----HPETVFH
FWIRLVQILQNGLSITTKD---PRIL----VTHCLVPKNSCSPSGD-AKL-VQKKPQASQ
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------HNQFSSRSS----K--K-TENKKH
-S-S--------------------EKNSPSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQP--------------LSLLSTLAASTGPQ------------------
----------------------------LSPIIGTVM-GLVQLPSWD-------RP----
-G--I-PPQ--AQ--------VQVLGSWG-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSN-----SAVFES------NFI--Q---------------------
-V------------TK-PGNWMDVCERSTTVILGVTSSVPSLPL----PNI--------L
LMANVTWPQGQ-------------------FSTWSVP-GCAPVVTL---SRILPL-----
KYVE-LRICDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWIRLVKILQRGLSITTKD---RRIQ----FSHCLVPKLPSSTE----TS-AGSLPSSRQ
PSEST--MLLAAEQTSDPFSNLSG------------------------------------
--------------KSQL----------------------TADRNTN-------TAIEID
NSNS--------------------FDKTPSPVASP--VI----------SNIPMRATLSH
SLWEQENPD-EHFL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MRPPLYPEVQEPP-----------------L-QSRLLCDVIKPTP
LSGVTVRVAPPPRFLPRLLPPLPSRCGDIAMRRERGP-------KPAL------------
---------------GGAGEAELGGMA------------------A-SP----TGHPRQL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGLAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RRQLKVKLSNHRAFY-------LELQAP---PESRDREFG
QWVR--------------------------LLYRL--RFQ-----------------SA-
PAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MAP-----AVMRR--LWRF-FFPPPP--PEPPKW----VPILGEM
QKTLQMA-EYL-PLRP----L-PMFES------NFT--Q---------------------
-VT------------Y-NGTPALLHNKSNKLTMGVAASLPGL----MLPDI--------L
LIARPPE--D----------------------------EECSSLIL---TRMIPL-----
DLAR-LYVDDLP--------TWRLKLRLRSGRHYF-------LALDAP---EHELAFLFD
RWIRLINMLRGSKLSKTPK---T-------EPSLL--EIP-----------------PE-
------------------------------------VTLAST-WHFQVQSQGK---LTVE
VADPTFPCKI--FSSHKPK-TKMKLT------KPIKH-SLRSQAV-------------GD
SVPLIWSQLQSSEDQMKVTKT--KSYPHACSDRPE-PLIHVS------------------
------------------------------------------------------------
--------------------------------------------DKASITIR---T----
--IFSIISN----TINQAH------KSD-----SEEDTSQGRL----METPSKCLSQNST
GFPVTVSSNQLDTLLWAQNLE-----DLMNPEYATLSS---LNTSYPPAF-YIFPPN---
--------PSFLK-SKD------------KARPTGSKKHVSP-----LS-SHKAACVPIE
SRK------MPFIL---DQ--SNKVPAK--------------------------------
----------P------APAQMASALPTPSRK----------TPTALWSR--GKASGALG
-HFFKSQPS--VSQKTPTTPGQPLKPQVITAPTQKTLTPNQKL-LQAPAHSQKAM-----
-HTKKDHLIVNTRSQKD-PTAPYQK-----ALDSRAKASGDPRTL--------QGGGVL-
ERKTEGKQEPVL---L------------VGGQNTTVVDVRAQTMPLHLPFA--TTKKQSK
EILISKTQ----EALKGREKLEDCAHKMK-E-TTVNLPNLKSKETEMQ-KRVLTEEIAVE
NPYTEDNRPFSAEGLALAKMKIMANS---KHQ-RLKPA-TISLPSSFSVASNVSSMSMLA
--NLPFDTSQTTFSDGSQVVVIEQSGSCTKVNKENTRHQMERKPAEDLPVSSNP------
----------------------RI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKQGQGS-------LSAL------------
---------------GGAGEAGPGGM-----------AERP--LVPAHP----HGRLGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHDES--------RLQLKVKFRTGRAFY-------LQLRAP---PETREREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
VAVPFTLEDS-------VLD---SEDDD---DDDD--EEEEL-LPP--------------
-------------------------------------EEL--QAI---------------
------------EARLDPQ---------------------------------------AS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKR--LFKI-RRTQAP--QEPQKW----VPILGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGAPALVHHKTNKLTMGVAASLPGL----VLPDI--------L
LLARPPE--D----------------------------RDCSNLNL---TRMIPL-----
DLAH-LYVHDLP--------TWRLKLRLITGRYYY-------LELDAP---DHELGFLFD
RWLRLINLLHEPTISWAPR---TMTP----C-L---------------------------
------------------------------------------------------------
------------LSAHG----------------QMAKHKFRSQAV-------------GD
SLPLLWSQLQPPKDQMKVTEK--KAYPGACPAGSK-TLIHVS------------------
------------------------------------------------------------
--------------------------------------------EKASITIR---T----
--IFSIISG----TMNQDNST--------------SKASRGRL----IETPTQRVSHNAH
DLSFTDSRGHMDTFLWTQDLD-----KLIDTESTSLSS-PLRMSPYSPAF-YIFPPG---
--------SSLTK-SND------------KAKPK-------P-----IG-SMKYMSSPIT
SGK------TPFIW---DK--SNKVPAE--------------------------------
----------P------APAQKAPAAPRSTQK----------------------SSAKSS
-PFYKTPPS--GSRKTPSVPGPPRKAPVLVTQPQKTLTPVLKR-PKAPAGSQKA------
VPPKKDILVLNTQCQAP--TARS------QAPDSKAKAPVDPSML--------QAGDML-
ERKSEGKQEPG-----------------VGEQKRKAVEMK--ATSPQLPST--TNKKQSK
EVLISKTQEITVEALKSRGKSEERVHKM--EKTTVNLPDLKSLEIESQKKWVLTKEVAVG
GPCLEDSRPFSVEGLALAKMMIMANS---KQQ-HLKPT-TISLPSWFSMTSRASAMSVLA
--NLPFNTSQMTLPERTQVVVREQPSSYTEMRENKPHQTEKN-PPKGSVGARIVG-----
-----TDLCGMGSPLGS------RMQRGWRWEPGS----VFTLEAT-QEMMVAWTRGC--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------NGCYGPKLT---L-------GAVGRL--PVPACA----PEGPGWL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPTKEDG----------------------------C----LQL---HGLFPL-----
QFVQ-LFVHKES--------RQQLKVKFCPGRTFY-------LQLRGP---AETRDLEFS
QWVR--------------------------LLYRL--RFY-----------------SGQ
GAVPFTQQEW-------GYE---EETDG------DQEEREGL-AG--L------------
--------------------------------------Q----VR---------------
------------EARLNPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIS-EEHVRR-------GRF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDAAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGMASAASPSTSTPGAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGIATGPRTDVAIAGAATSP--ATGAMS-IAT----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSEGTS--TSMVGAASLSQDS-SLSAAFAGS
MM-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-CQKVSQPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAG---------------------ES
HRRTAGDK-NQKASSHRSVSGHKNTRD--------------------DKK--EKGHSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----TQELGKNRSASSTG-----PLRK--------
-KASKISSFLRSLRATPGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTMTSEK-------------TEMIVFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHGKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDQEPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETNKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNADFLLPY-YTAQSG--SSMSMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GQA----TKRKKR--KAAKNLEL---TRLLPL-----
RFVR-ISVQDHE--------KQQLRLKFATGRSCY-------LQLCPA---LDTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WMPVFQEDRR-S-------L-G-
------------------------------------------------------------
------------AVNL------------QGKGD---QDQV-SIQS---LH-MV-SEVCGA
TSA-AY---------AGGEGLQNDFNKPTNVLNASIPKTSTE-LA-EE-P-AT-------
------------------------------------------------------------
---------------G-GIKEAAAAG---------AAAGAAT--GTVAGALS-VAAA---
--N-SA-PG-QVSA-AIAGA-------------------------ATI-GAGGNKGNMAL
AGT-------ASM-APNSTKVAVAGAAGKSSEHV---S--SASMSLSREG-SVSLAIAGV
VL-TSRTAAEADM--DAAA------------GPPVSTRQSKSSLSGQHGR--ERTQASAE
GCK------EG-----RERREKDRALGR-SSHRRRTG---------------------ES
RHKTRGDKIAQKSSSRS-SFSHRANRD--------------------DKK--EKGCGNPG
-SSRHR-DSHKGVSHTPISKESRT-----SHKSGRSLWTTSSG-----S-SK--------
-GLGRVSSFLRNVRANLTTKVVG---------TPHGR---DVNVMAKMAE-RSTNVAIAE
TAEGGQGLE-TV-GSMTPDI-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHGKT-WRKSK---NTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDREPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPRNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKAENEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETNKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKP-WWNSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQIVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRHWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-STAPSIIL---KSILPL-----
KFVE-LQICDHH--------ERILRLRTVTEKIYF-------LKLHPD-----HPETVFL
FWIRLVQILQKGLSITTKD---PSIL----VTHCLVPKSLCNPCGK-SEL-VQKKPPCSR
PSESL--MQLMAQGESEALSQIFA------------------------------------
--------------DLHQ------------------QKQYR--RSKEMQI--N-------
KTSS--------------------EKATPSEDSIP--CT----------RDLSWRDAFTY
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLTGGISI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNRR--K-SV---------------DEPSPGHL
KNMLEEG-EYS-PFVT-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSAH----KIPSV--------M
LLAHLKPTARTH-----------GEQL---FESLLTT-PSSEKLVL---TRFLPL-----
QFVT-LSVHDAE--------SMRLKVKLVSGRAYY-------LQLCGP---ANKQDGLFA
QWKDLIGLLHQEKARAS--KVSRGSN-LSELTNNT--EVPSSMDIMAVT-----AFADTQ
TPATHLGADPVQVAESMNFSEITDVTDI---TDVTDIPENEV-TE---FPDIK-------
---------I-----V---------TEVTEVIEALEVTEV-------KSS-SDATNFSGV
TVVFENDDIRR--AKQEEKV---DVLKPGCLRDTR-SKTEFKE-----------------
---------SS--------------------------------------------K----
--------------------RVTISN-ITLTFEGERCFQTLLTPIQSEATLP---K----
--EMS-EAASEDKKADSRNAALKTVESRYVGRQVPEA--SK----GTCKQ----I-----
CV----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKKNKS--K-SKKLVN--KQDALCIPH-YYRLGHL
KNILDGG-EYA-PYVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNHVF----KTPNM--------M
LLAHLTTEARKE-----------QEPL---FKTILKS-SSPGNLVL---TRFIPL-----
QFVT-ISVHSAK--------NMRLKVKLINGRSYY-------LQLCAP---MYKQDIIFS
QWVDLIPLLNQEKAKTT--QVSEISS-LSEITNST--DITGSLDITDIT-----ALPELQ
TMCSKTQRCPCNIMESEDFSEYTDATDVT---DVTDVLENEV-TD---VQDIK-------
---------I-----V---------TEVT----------------EVSEV-QISTNVSGV
KIVFENDDIIK--NKQEEKD---NNLKHRSLRDTK-TKNDYRD-----------------
---------SP--------------------------------------------K----
--------------------HVSISN-RTLALEDEETFQTTLTPVKSKEDIC---K----
--EIY-DETSEEKMISLQNTHLKATESRSKHSTLERLFRDHLQ---TLPSVRSQLTSQFP
ESNLLGVNYSKMSSTGGSTY--------------------GSPRPRPPHL-YGVIH----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSG-----------------
---------------------GKRIRSSECVLPY-YTARSY--RSMGVFN----TSMGDL
QRQLYKGGEYE-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHAKR-------GLL----PKKRTQ--MPKRTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVDSCSST---PTIQ----TGDAGT-P-----EDIKSL-------L---
------------------------------------------------------------
------------ASDL------------CGEGD---QDS-----G---LL-KL-HEVRGA
SSS-AF---------AGGEGIQLAALA--AS-----------------------------
------------------------------------------------------------
----------ATGGAARTVGGVAAVGTTTGPTAGTAVAGTATRP--AAGAMS-MAA----
-AK-SAGSG-QVTT-ALAGT-------------------------AIK-ESGEGRASKAV
AAS-------ASV-SADNINVAMAGAASSSSAGTS---T-AGAASVSQD--SMNVVFAGT
MM-TKAPMGEKAE--GSAV------------VPVVSALQSESYMCERDG-SQKVSQVSAE
ARK------EKRER--REK-NRTA--SRKSSHHRRTGESH--------------------
RHRSGGHK-SRKSSSHHSVSGHRSKRE--------------------EKK--EKGSRKAR
SSRGRS-SPHKNASRSSSNKGSRT-----SRKAGKGRSAASSS-----SVSK--------
-KSSKISSFLRSFLTASSSKIAL---------GSRDR---EVDIMTKTVE-KRNIETKVE
KGQAGQELE-LY-GTMTSET-------------TETIIFEAVSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MDVKEESLLPY-YTAQSG--AEVGMFNGLFDTATGKL
QQQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------R-YGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAP-F-DELLGH-------GQST-NSTKGKKR--KAGKTLEL---TRLLPL-----
KFVR-ISVHRRD--------EQQLRLKFATGRSCY-------LQLCPP---PESKDDLFS
YWEKLIDLLRPPVDSNTST---YAIP----AGDMM--STPFLDEELKIP-------KKKG
------------------------------------------------------------
----------KRKSGH------------RKKRD---LYKV-SVKS---LP-A-TTDVSAI
SSS-AF---------SGGEET-HDSHISTIVSRIPTPKVSSKVLA-RE-SA---------
------------------------------------------------------------
-------------------------------------SEAIV--CDLVDSLS-LAAN---
--M-PEGLG-QINK-ATVEE-------------------------AAL-GARGSKSHLTI
AST-------GKM-SPKSMKIALAGMASKSLEYI---P--SSPASLSRKE-IMTVTNSRI
ET-TGKSVGETAN--DPVP------------VVLALTLPSESHSNEETG-RRKAYETSTK
AHK------ERRSR--RDQRAKERVGSR-SEQHQRTG---------------------EG
H-KTEGDKEFQKSTSHR-GVG-----D--------------------D-K--------DK
-GSKRN-RWHKGVSHVPITKESRS-----SHKLSRTISTASSA-----STSK--------
-RVGRISLFLRNIRASLAGKSLA---------P-RGQ---DVGIMTKTLE-TTDVKAIME
A-EDGQGLE-II-DSVTSEV-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCSP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSDCLLPY-YTAKSG--SGVGMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPSLPL----PDV--------M
LLARPATSC-EEYGGH-------SQP----AKGRNR--KAAKALEL---TRLLPL-----
KFVR-ITVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LDARKDLFA
YWEKLIYLLRPPVDSNSST---YAVP----AEDM---CMPVLEEDRM-S-------L-G-
------------------------------------------------------------
------------ASDL------------QGKGD---QDQV-SIRS---LH-MA-SEVCGA
TSA-AY---------AGGEGVPHDSHKPVGVPDASSPKTKPTDFA-KE-SATG-------
------------------------------------------------------------
-----------------ASTEVAVAG--------------AT--GGTAGAFS-LSVS---
------KTG-DVS--TISGG-------------------------AVL--G-GSKSNIAI
AGT-------ASK-SPKSIKVAVAGATSKVSEHV---S--SESKNISPEEGTMSVVTAGI
EP-ASKTAGEEDN--SPGE------------ELPMVTLLSESSVSEPHGRRR--AHASAE
GRK--------EGK--REKRDKDRALSDRSTHHRRTG---------------------ES
RRKSSRDKLARKSSSQS-SSSHHASRE--------------------DRK-EKHRR-SPG
-GSRTR-SSHKGASHTLLTKDSRT-----SHKSGRSMSTTSSG-----S-SK--------
-RLSRIGSFLKNVKANLTTKAVA---------SQRGR---DVDITAKTEE-KNTMEAIVE
AGESGQDLK-MA-GSVSSEI-------------KETVTFITH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
------AD---FQVTK-PGNWRNVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GEAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSTET--TV-SGNP--SPR
AQEPQ--LKLPGLTQEGSFFQ---------------------------------------
-----------------L----------------------EEKENND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPIRAVLSH
TFWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAI-RDPG--PGVEL-----GVVDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNI--------L
LMANVTWPHGP-------------------FSTSST--LGAPVITL---SRILPL-----
KYVE-LKIYDRT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSNSSTET--TT-ESSLPASSQ
NSEAI--MLLAAEQNSSSLLERSN------------------------------------
--------------RHQI----------------------SGDRHTD-------TATETH
NSD---------------------NCKTTPLVASS--------------ASMPMRAALTH
SLWEQEDSN-ENFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MK--KN--R-NKKAMN--KQEALFIPH-YYKLGHL
KNILDGG-EYA-PYVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPIF----KTPNM--------M
LLAHLTPEARKE-----------PDPL---FKTLLKS-SSSGTLVL---TRFIPL-----
QFVT-LSVHCAK--------NMRLKVKLINGRSYY-------LQLCAP---VYKQDIIFS
QWVDLIPLLNQEKMKNT--KVSEVSS-LSELTNST--DITGSMDITDIT-----AFRELQ
PRHPKTHRYPCNIMESADFSEYTDVTDVTDVTDVTDILDNGV-TD---VQDIK-------
---------I-----V---------TEVT---------EV----SEVSDV-KVATNISGV
KIVFENDDIIK--TKQEEKE---YTLKHRSLRDTK-TKSDYRD-----------------
---------SP--------------------------------------------N----
--------------------HVTMSN-IALTLQDEGCFQTTLTPVKSKEDIY---K----
--EIC-DEASEENMIRLQNIHLKATESRSTRTDSDISD-GELK-----------------
----LGRYLHKQYSSREQSF--------------------THSLGSLPRG-VVFLHL---
----------LL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTMSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MGQPLWPHLQEPPPPGTSSQ----------T-RSPLLCDVIKPAP
HHDVTVRVVPPPRFLPRLLRPLPS-DGDIAMRRDRGP-------KPAL------------
---------------GGAGEVEPGGMA------------------A-SP----TGRPRRL
QRYLQSG-EFD-QFRD-----LPIFES------NFV--QFCPHIYPAPT------SDLWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLEVKLNTSRTFY-------LQLRAP---LKTRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
STVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------VP-----------------
---------------------NEETMSSECMLPY-YTAHGY--RSTGVFS----TSMGNL
QQQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVTDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPVKAC-EEHSVP-------DRI----IKRRGR--KATKNLEL---TRLLPL-----
KFVK-ISVHNRD--------KQQLRVKLATGRTFY-------LQLCPS---SDAREDLFS
YWEKLIYLLRPPVESYSSI---PTLD----TGDATI-TSGCLTEDDRSL-------L---
------------------------------------------------------------
------------SAVT------------QGEGN---QNEV----R---LH-KL-HEVSGA
TSA-AY---------AGGEGIQHAFHSSVTKSPGPARKGAAAGAT-TG-PVGGTVVAGMT
TGSAAGTMMTGAMVGSAAGAAM-AGAMAGSTAGTAAAGSTTRGSAAGA-----TMAGAMA
GS--AAGTAAAGSTTTGSAAGTAAAGAMAGSGAGPAMAGTAASP--AVGSMS-MAA----
-TK-STGPR-QANA-TLAGA-------------------------AAK-GPRESGSSKAM
A---------AGM-SSEGANVVLVRAASTTSVATSN-TSAAAT---TQ-GSSVSVVMAGT
TR-KS-------AV-GSVE------------RPLVSTLQSEGYMSERDG-SQRASHPRAE
TQE------K-KER--RE-KDRHV--SKNSSRHHRTG---------------------ES
RRKTGGHKSSRKSSSHRSVASHEATKD--------------------DKK--EKGHSRRR
-RKGHSSSSHKSVSHSPSRKESRT-----APKLGKSLSTISSA-----SVSK--------
-KSSRISTFLRSFKVGS---------------KAQDK---EMDIVAKTVE-RCNIETTVE
KAEQGQEL--IS-GTLTSET-------------METIIFEAKPV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPY-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDITNCSGV
TVVFENNDLIR--ARQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVVSEANTS---K----
--EME-NTTSEEKTPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNEPCLPY-YTAHSY--RSLSVFR----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
LLARPAKVY-EEHARQ-------GWF----AKGRRR--RPPKTLEL---TRLIPL-----
KFVK-ISIHNHE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVDSYSSA---PTLL----TGDTVP-------EDNKSL-------L---
------------------------------------------------------------
------------AAEH------------HRKGN---QSET----G---FH-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGMARAASLDTSTAGAAEGA-A-------------
------------------------------------------------------------
---------------AKTAGGV--AGAATGPRAGVAIAGAAMSP--ATGAVS-IAA----
-TK-PAGPG-QVIT-TLVGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDSVDFALVGAASTSSAGTS--TTMAGAASLSQDS-SLSTAFAGS
MT-TGKCVAERNQ--GPAL------------GPLVSTLQSEGYMSERDG-SQKVSQPSAE
AWN------EKKER--REKKDKRP--SRKSSHHRKAG---------------------ES
HRRTAGDK-TQKASSHRSTSGHKNTRD--------------------DKK--EKGRSKVR
-GKGRG-SSRKSSSHSSTKKELRT-----THKLGKNRSASSTG-----ALSK--------
-KASKISSFLRSLRATAGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KA---QELEVIS-GTMTSEM-------------TEMIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEDCCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
VLARPAAVC--DNARC-------GPA----TQKRDS--LPAEILEL---TRLLPL-----
MFVK-ITIHNSV--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---RAIL----AGNTL--DSSVLEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KPAP------------
---------------GGA--------------------DRP--LVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKESG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRAP---AETRDREFG
RWV---------------------------------------------------------
--LPFTHEDT-------APE---EEDEE---EEEE-----E---------EGE-------
--------------------E-----------GQLRAPEV--------------------
--------------RAGPR---------------------------------------AQ
GCWARKDGKEGPGRPAGAWSLG-------SEGGRL------DPASEG-----GGLR----
--------------------HGSLRL-KKEVTH-----------------AF---L----
--LLLRGSK----EK---------------------ATGSGS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------T----
-------------------------MKKNKR--N-PTTRIN--ERDAISIPT-SQDPRNL
QNMLDGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSETR----KTPNV--------M
LLAHLTPEAQKN-----------TKSL---FQSLLTS-PSPQNLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNEEKAKVS--KLSEVSS-LSEITNST--DITGSGDIMDIA-----ACTTLQ
SPPLCLCSEPVHAVESTDFSDFTDVTDVTDVTDVTDVPENED-TE---APDIN-------
---------I-----V---------TEVTEVTD---L--------------CDDPNCSEV
TVVFENDDILR--AKQEEKEKMGNTLKPGCLRDTK-IKNEFRE-----------------
---------PS--------------------------------------------K----
--------------------HVTISN-VTLTFQGERCFHTTLTQEESDTSSS---N----
--QLS-TRSSEIRTTEFKNLALKAEESRYVSNKIRNLKG---HHMRTIHAKRSELNIKLR
KYNFLNIK--LR-K-LS-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRPEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------GDCSGLVL---TRMIPL-----
DLIH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMCT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNFPYKKSPVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVGKKPAEK--KSHPDFHPDRTH-TQAH---F----------------
------------------------------------------------------------
-------------------------------------------SEKTSITIW---T----
--IFSIISS----TAKQTQSSPKACTSA-----SEEATGQGPV----FESPSYCVSADSP
DCFFLGSGSSLDPCLWHQDME-----DLMDSESSTLSSATSGLAPYPRAA-RFSTPY---
--------SSIPR-GRE------------KARSMGSHQGRGP-----PP-CQT---GPVT
SRK------APFLV---DQ--SQTLPAV--------------------------------
----------P------ASSWKPPPGLAPPQKVSAASTPP--------------------
-----------------------WKASAVPAPPQKAPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKAPQTSPPQYQMAPGSPASRGRLPGD--VL----PTGIPGRAALE
RSPSGGKPEPAV---------------TVGTQETD-VVMTTQVKSLESPFT--VTKKESK
DILVSKTQEVTLEAFRGQGKLEDRAHLAKLEERSLDPPGARSKELEQRKRWVETKELAVE
DPSQEHSRPFSMETLTLAKLTILANS---KEQ-RVKPS-LVSLPSWLLATSQASATSMMA
--SMPFHPGQLSSPEGKPVVVREQPESHTWVKEGKRQWGES--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQAPLPLPASRWEGL--PPSP--LSETPISKTEATAKASQQ
PKRLSEEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVFNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHGKT-WRKSK---KRVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDREPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPA-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPRNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKAENEALSQIFA------------------------------------
--------------DLHQ------------------QNQLSFRSSKKV-------ETNKN
SSGR--------------------DSSR--EDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
LLAHLKPTEQEH-----------GEEL---FTSLLTS-PAAEKLVL---TRFLPL-----
QFVT-LSVHNVK--------NMCLKVKLVSGRAYY-------LQLCVP---ANKQDALFS
QWMDLIYHLNQEKAKAS--TVSEVSS-LSEITNST--EVTSSMDIMGIT-----ASADIQ
TTHTYPCTDPVHVTESINFSEFTDVTDI---TDVTDIPENEV-TE---FPDVN-------
---------I-----V---------TEVTEVIE---AAEV-------KSS-SEATSFSGV
TVVFENDDIRK--AKQEEKRKEENVLKTGCLRDSR-SKTQFRV-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGERCFQTTLTPIKSETNVS---K----
--EMS-DVTAEKKKTDLKNTALKTMGSRCVRSLRTESDTSGLNSFPVFPL----ISISFP
LFTLL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------SSSECLLPY-YTAQSG--SGVGMFN----TVMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPLLPL----PDV--------M
LLARPATGC-EEFPGR-------GQA----TKGKNR--KGSKTLEL---TRLLPL-----
KFVR-ISVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LEAREDLFT
YWEKLIYLLRPPMDSNSST---YAIP----AEDMI--CMPVFEEDNRST-------L-T-
------------------------------------------------------------
------------AAEF------------QGKGD---QDQV-SIRS---LH-MV-SEVSGA
TSA-AY---------AGGEGIQQDSHKPAAVLGVPTPKTKYPELV-KE-S--D-------
------------------------------------------------------------
---------------T-GITEA-------------AEAGVAA--RTSTGTLS-VAAV---
--K-SASSG-QGGT-AAAGG---------------------------------SQGSILI
AGT-------ANI-SPTNIKVAVAGAIGQSSEYL---S--SLSTSLSPGG-SSSVAIAGV
GP-TSNTVAEIIN--DPAEGETVLG------------ESLEG-------GQLQISHAGAE
ARK------ERRER--RERREKERARGR-SSRHRRVG---------------------EG
RRKTAGDKLGRKPSGHR-A--SREDKK--------------------EK-----GRGSPR
-GSRHS-PSHKGISHTPITKESRT-----SHKSGRSLSTTSSG-----SASK--------
-RLSRISSFLRNVRANLTTKAVA---------SPQGQ---DVDITAKTVE-KTNMEAIVE
TGESGQGVE-IV-GSVTSEI-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MEK-------NKQSED--DKDPVWIPE-AFRLGRL
KNVLDGG-EYA-PFIT-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTIGICSSNPVL----KTPNV--------M
LLAHLTPEARKE-----------SEPL---FKRLLSS-SSTDKLVL---TRFLPL-----
QFVT-LSVHSAK--------NMRLKVKLISGRAYY-------LQLCAP---VYKQDIVFS
QWVDLITLLNQEKARTS--KVSEVSS-LSEITNST--DITGSMDIMDIT-----AFAELQ
AVHSHTRIYSDTVTQSADFSEFTDVTDITDVTDVTDIPETGA-TD---VPDIK-------
---------I-----V---------TEVTEVIE----------------D-KEAPNVPGV
TVVFENDDIIK--AKEEEKE---NVLRHGCLLDIK-SKNEFKD-----------------
---------AS--------------------------------------------K----
--------------------HVTISD-LTLTFQGERCFQTTLTSIKSEENIS---I----
--ETG-DKALEEKLTDLPNARLKATESRRTRTDSDTTDGE-AK-----------------
----PGRYLFKQYS-FREKF--------------------FTRSLGSLPG-FVFLYL---
----------LIH-----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGRGR--KPSKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPTDSCSS----PILP----TGDTST-P-----EETKSL-------L---
------------------------------------------------------------
------------GSDI------------HGEGD---QDS-----G---RQ-KL-RDVSGA
TSA-AY---------AGGEGIQPAIPASVAIGS---------------------------
R---------GPAKGVAAGASV-----------------GT-------------------
-------------VAAGITTG---------PSAGVAKVGTATCP--PSGAIS-MAA----
-NK-SPGSG-QIVT-SLAGT-------------------------ASS-DSGGCGSSKNL
AAV-------ANI-STEVIDVVLAGAASSSSECTS----TGGAASVNPDS-NLNVAFAGT
MT-TKGPAADK--PE----------------APLVSTLQSEGYMCERDG-SQKVSHTGSE
PRK------EKRER--PEKKDRNA--SRKGSHHRRTGAS---------------------
HRSSGKEK-PRKSSSHRSVSGHGKTRE--------------------DKK--GKRQSSIR
-GKRRSS-SHKS--------ESRT-----AHKPRKNRSSASSG-----STSK--------
-KSSKISSFLRSFIIRPTSKPGA---------NSCDM--GGVDIVTKTVE-KHNLEAKME
KG---SELE-FS-GIVT-ET-------------TERIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KPAS------------
---------------GRA--------------------DRP--LAQAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVHDVS--------RQQLKVKFRTGRAFY-------LQLRAP---PETRDCEFG
RWVR--------------------------LLYRL--RFH-----------------SPT
CAVPFTHEDT-------VPE---ESE---------D---ED---------EVE-------
--------------------E-----------GQLQPPEF--HAT---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAV-SDSG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFPD-----SVVFES------NFI--Q---------------------
-V------------TK-AGNWTDVFEGSTIVILGVTSSVPSLPL----PNI--------L
LMANISWPQSP-------------------FSTWITP-GAAPVITL---SRILPL-----
KYVE-LQIYDRI--------QRILRVRTVTEKIYY-------LRLHKN-----HPEAVFQ
FWIRLVRILRKGLSITTKD---PRIR----FNHCLVPKRTRHSTET--TP-ENSLPSSSQ
PSETF--LLQEAEQTTDRFLELSG------------------------------------
--------------RTQP----------------------PADRNTN-------TAIKKD
ESN---------------------CCNILSKVASP--IT----------INIPMRTTLWH
SLWEQEDPG-GHCL-----------------QAPAASSLG--------------------
----------------------------------ENFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAI-RDPG--PGVEL-----GVVDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNI--------L
LMANVTWPHGP-------------------FSTCST--LGAPVITL---SRILPL-----
KYVE-LQIYDRT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSNSSTET--AT-ESSLPASSQ
NSEAI--MLLAAERNSSSLLELSN------------------------------------
--------------RHQT----------------------SRDRHTD-------TATETD
NSG---------------------NCKSTPLVASS--------------ASMPMRAALTH
SLWEQEDSN-ENFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------MGPPLPDLQEPPPPGTSSQ----------T-RSPLLCDVIKPAP
HRDVTVRVVPPPRFLPRLLHPLPS-SGDIAMRRDRGP-------KTAL------------
---------------GGAGEVEPGGMA------------------A-SP----MGRPRRL
QRYLQSG-EFD-QFRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLEVKLNTSRTFY-------LQLRAP---LETRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
SAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------NFI--Q---------------------
-TRRQ---EVDIKVTK-PGSWMDVYEGSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGQ-------------------FSSWSTP-DCAPVVTL---SRILPL-----
KFVE-LQICDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSSSSTRI--TP-ESSLPSSTQ
PSENF--RLLAAEQTSDSFSNISG------------------------------------
--------------KPQL----------------------TADCNTN-------IAIKID
NLDS--------------------Y-KIPSRVASP--VN----------LNIPMRAALSH
SLWEQENPD-EHFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNKIRGLPPEA-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSN-----SAVFES------YFI--Q---------------------
-V------------TE-PGNWMDVCEGSTTMILGVTSSVPCLPL----PNV--------L
LMANVTWPRSR-------------------FSTQSTP-GHAPVITL---RRILPL-----
KYVE-LRICDRL--------QRILRVRTVTEKIYY-------LRLHKK-----HPEAVFQ
FWMRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMTNNCTET--TV-TETIH----
------------------------------------------------------------
---------------PPR----------------------PPRVSID-------TAIGID
NSI---------------------SDKTPLPVVSS--VD----------LKVPMRATLSH
SLWEQENPD-EHFL-----------------HVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKRRHEP-------RPAL------------
---------------GGAGEAVPGGM-----------AERP--LVPAYP----AGRPGRL
QRHLQSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTVGVAASSPAL----ELPDL--------L
LLAGPTKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFIHDES--------RCQLKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------AAH
GAVPFTQEDS-------APE---DLDDD---EEDE----EDE-LEC--------------
-------------------------------------EEL--HAM---------------
------------EARLEPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRNVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPETVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSTET--TP-ENSLLSSPQ
PSKSL--VLLAAEQTSGSFSPLSG------------------------------------
--------------KPQP----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MATKSECVLPY-YTAQSA--SGVGLFN----TAMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPATST-EDPAGR-------GP-----NKGRKR--RATRPLEL---TRLLPL-----
KFVR-ISIHDHG--------KQQLRLKFATGRSCY-------LQLCPP---LDAREDLFA
YWEKLIYLLRPPVDSNSST---YAIP----AEDTI--CMPSFEEEDRTS-------L-T-
------------------------------------------------------------
------------AAEF------------QGKGD---QDQV-SIRS---LH-LV-HEVHRA
TSA-AY---------AGGERTKYDLHKSTTLPDASTPKRKLTILS-KE-STAR-------
------------------------------------------------------------
---------------A-GAA-------------------------AIAGTLG-VAAT---
--K-SASSG-QVSK-AIARG-------------------------VAI-EARGSKSHLTI
TGT-------SKT-SPKSFRVARAGTASKSVEHI---P--NTGTGLCPEG-SVGITR--V
DV-THENVEL-ES--D------------LAIELLSSPLLNESRMGRQAG-QQRIS--LDT
ARK------EKRER--REQREKDRG-----RHQTRTG---------------------EG
HRKTEGDKITRKSSHRA-T---RDDKK--------------------ET---GS--VGSW
-ENRRN-ISHKGRGHIPISKESRT-----SHKSGRSFSTASSA-----STNK--------
-RLGRINSFLKNIRSNLTTKGIA---------SPRGI---T-------VE-RANMEAIME
TAEHGQGLE-II-NSVTSDI------------VVETMTLESH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPPTKT-WWKSK---KTVKV
TRSYPTFP-------------SLTAWEEFRGL-LRVDGEPN--PGVGL-----GVEEGLL
CQKVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-SRNWIDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-SIAPNIIL---KRILPL-----
KFVE-LQVCDRL--------QRILRLRTVTEKIYY-------LKLHPN-----HPECVFH
FWTRLVQILQKGLSITTKD---PNIL----VTHCLVPKNCCNPSGD-AKL-VQKKLQVSH
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQFSFRSSKKL-------ETNKD
SSGK--------------------GGHE--EDSIP--CT----------RDLRWRDSFMY
GEWERENPS-GPQP--------------LSLLSTLAASTRPQ------------------
----------------------------LAPPIG--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTVSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKVC-EEHVRQ-------GWF----AKGRGR--RPVKNLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LH-KT-CDVSAA
TSS-AY---------AGGEGIQHASHRTASAASLSRGTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAMS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSV
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTASLSQDS-SLSAAFAGS
MT-TRKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKLSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRR--------
-KASKIGSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

MEIMLGQRHLRESNSLWPGSPESLYRGPWWLLEVPLKRQRGPGEAATASSYSPAQRLQSF
PQSPCLECGLPVLPSPELAEQRALGFGSELCRKGPGAPPETGPNFRVAPPHPLCVQGLER
TFLRGAAPFFLVLPCMGPGECCQLAPPDPPDPCMRSQRGPPGCVTPARLPLLS-SAVPES
HSQSALPAES---ILALLQQPPPPPPQSPDLQAHRDSLSPMKPRKPSP------------
-----------------------VVLPGELHLPE---VEAE--LSFPLC----FPKPGPL
QRAVAEG-NYP-PLGP----FTAMIES------DFL--Q---------------------
-VT------------N-KGEPVFLHKKENPVTMAVASSFPGL----LLPDL--------V
LLARPVQS-K----------------------------KQPPRLEL---TRLLPA-----
QLVR-LFVHSEA--------GWRLKLRLASGRSFY-------LRLVAE---PAEGCLLFN
RWRFLIYLMQGPIPAWARS---PDEQ----AAQDE--SAP-----------------MSA
AEAPPKRKEV-------AF------PPQ---YPVPRTKGSPG-W----------------
TWDKALHYPGPLSQLMDQQSAPAL---------PEVMSEVMSRAE-------------AA
PMSFRSQQ-KL-PVRREEQQK--WAWPQAC--------GGG-------------------
------------------------------------------------------------
-------------------------------------------GEGAGAG----------
-------------A--GAGTRAW----R-----RGRAGPGHPA----GQSAVGCFLRSEP
TLFRRSTPGSLVEVEGKG-------------------------RPPPPCS-PAL--W---
-------LGALPE-A---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMLPL-----
DLVH-LCVHDLS--------AWLLKLRLVSGRQYY-------LALDAP---DKEVGFLFH
CWVRLINLLEEPAPTWTRR---TMRT----A--PL--DVP-----------------LA-
------------------------------------EAPAST-WHLQDQPISR---HADQ
GR----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KPAP------------
---------------GGA--------------------DRP--LVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKESG----------------------------R----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRAP---AETRDREFG
RWVR--------------------------LLYRL--RFH-----------------SPA
CVVPFTHEDT-------APE---EEDEE---EEEE-----E---------EGE-------
--------------------E-----------GQLRAPEV--------------------
--------------RAGPR---------------------------------------AQ
GCWARKDGKEGPGRPAGAWSLG-------SEGGRL------DPASEG-----GGLR----
--------------------HGSLRL-KKEVTH-----------------AF---L----
--LLLRGSK----EK---------------------ATGSGS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MVTNSECLLPY-YTAQSS--SGTGMFS----TTMGKL
QRHLHKG-EYD-MFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILLI----PDV--------M
LLARPATNC-EEFEGF-------SQA----TKGKSR--KGPKPLEL---TRLLPL-----
KFVR-ISVHDRQ--------KQQLRLKFATGRSCY-------LQLCPP---LDAREDLFT
YWEKLIYLLRPPVDSNSST---YATP----AEDML--CMPALADEDRTS-------L-A-
------------------------------------------------------------
------------AQDS------------QGKGD---QDQV-SIRS---LH-VV-PEVTRA
TSA-AY---------AGGEGVKPGSHTSNATPKISTSKSRSTEFA-QD-S----------
------------------------------------------------------------
------------------------------------TEAVAA--GTASGTLS-VAAT---
--K-SG-SG-EVNA-ALAGA-------------------------ASVG---EGESKSPR
AGT-------DKT-PPKSLSVALAGAVNQFSEPR---S-----DGFSPEN-SMSAAFAGG
EA-TSNEPGKAPN--PAAGG----------------TMASKSPKGA-EAGQQRMPPASEA
TLK------ERREK--KKRED--RATS-RGSSHRKTH---------------------EG
RHRTSEDKMARKSSSSH---------------------------------------RSAR
-GGRHN-RAPKGISRSPIEKESRT-----SHKSGRSLSTTSSG-----STPK--------
-RRGKISSFLRNVKANLRTKGMA---------SLRGG---DVDVVAKTVE-KTKLEAIVE
TAESGQGVE-IV-SSVTSEV-------------TEAVIVEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNEPCLPY-YTAHSY--RSMSVFR----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
LLARPAKVY-EEHARQ-------GWF----AKGRRR--RPPKTLEL---TRLIPL-----
KFVK-ISIHNHE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVDSYSST---PTLL----TGDTAP-------EDNKSL-------L---
------------------------------------------------------------
------------AAER------------HRKGD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGMASATSLDTSTAGAAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGV--AAAATGPRAGVAIAGAAMSP--ATGAVS-IAA----
-TK-PAGPG-QVIT-TLAGA-------------------------AIK-NPGENESSKSM
AGV-------ANI-SSDSINLALAGVASTSSAGTS--TTMAGAASLSQDS-SLSTAFAGS
-T-TGKCVAERTQ--GPPL------------GPLVSTLQSEGYMSERDG-SQKVSQPSAE
AWN------EKKER--REKKDKRP--SRKSSHHRKAG---------------------ES
HRRTAGDK-TQKASSHRSISGHKNTRD--------------------DKK--EKGRSKAR
-GKGRG-SSRKSSSHSSTKKESRT-----THKLGKKRSASSTG-----ALSK--------
-KASKISSFLRSLRATAGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KA---QELEVIS-GTMTSEM-------------TEMIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKR--LWNM-RRAQPP--QGPPMW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGGPVFVHHSANRLTMGVAASLPGL----VLPDI--------L
LIAQPPQ--S----------------------------RDCSGLTL---TRMIPL-----
DLAH-LYVHDLP--------TWRIKLRLITGRYYY-------LELDAP---DHELGFLFD
CWIRLINLLHEPNMTWVPR---TLKT----P--PL--DLP-----------------LE-
------------------------------------VAPAST-WQLQVGSQCV---E---
VAKNIYPYNS--RTAQKQRKAK-----------VLKH-KLKSQAV-------------GD
SLPLMCSQMGHPDVKKKP-TK--KFHPDACPERSN-TQIHVS------------------
------------------------------------------------------------
--------------------------------------------DKDSITIR---T----
--IFSIISK-------------TACTSN-----SEGATGWGGL----IQTPSHCISGDSP
NFIFLNSYKHMDTFMWPQGFE-----DLMDPESSALSS-SLHLSPYPPAL-YCSPPH---
--------SSFPR-SKA------------K--PMSSMKNRRP-----LP-SKK---VPIT
IRR------GPFIL---DQ--SHKVRDV--------------------------------
----------P------ALPRKAPAAPPSTQKAIP--DLSWKASPLLPGP--QKTPHIPD
-LSWKTPVLLKFPHTS--------------AIPQKEMLPP--------------------
-TPKKECLVPHTPSQKF-LASSSQYQQVNDLPTSGAKAPIDPCM----------LGGVLG
RNKTEGKQEPVM---L------------VGLHETKVIDIRNQTRTLESPST--TTQKESK
DILISKSM-------------EGRFYEKK-EEVTVDHHDKKSKEVGQQKRWVTTKKMAIE
LPLPEGSRPFSVEGLTLAKLMITANS---QEQ-HLKPP-VVSLPSWLSMASRASTMSRMA
--NMPFACSQM--K---PVVVREQPEFHMWVKNENTQQWTKRGPSWDPVGSSKPR---VQ
S-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

MEIMLGQRHLRESNSLWPGSPESLYRGTWWLLEVPLKRRREPGEAATASSYSPAQRLQSF
PQSPCLEWGLPVLPSPELAEQRALGFGSELCRKGPGASPDKGPNFRV-PPHPLCGQGLER
TFLRGAAPFFLVLPCMGPGECCQLAPPDPPDPCMRSQWGPPGCVTPGRLPLLS-SAVPES
HSQSALPAES---ILALLQQPPPPPPQSPDLQAHRDSLSPMKPRKPSP------------
-----------------------VVLPGELHLPE-GEVEAE--LSFPLC----FPKPGPL
QRAVAEG-NYP-PLGP----FTAMFES------DFV--Q---------------------
-VT------------N-KGEPVFLHKKENPVTMAVASSFPGL----LLPDL--------V
LLARPVQS-K----------------------------KQPPRLEL---TRLLPA-----
HLVR-LFVHSEA--------GWRLKLRLASGRSFY-------LRLVAE---PAEGCLLFN
LWRFLIFLMQGPIAAWARS---PDEQ----AAQLV--TSR-----------------SLF
TR-PLSRCPE-------SL------QVK---LCEEKQKGKSS-SKSH-------------
LPPIMFSFTASLHELLH-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNKR--E-SI---------------DEHDPGHL
QNMLDGG-GYA-PFVS-----PPMIQS------NFI--Q---------------------
-VN------------R-RGESIYVHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLKPTAQKH-----------GKPL---FKSLLTS-P-TEKLVL---TRFLPL-----
QFVT-LSVHNAE--------NMCLNVKLVSGRAYY-------LQLCVP---ANKKDALFS
QWMDLICLLHQEKAKAS--KVSEVSS-LSEITNST--EVTSSMAIMDIT-----AFN---
---------PIHVTESIHFSEFSDITDI---TDVTDIPENEV-ME---CPDVR-------
---------I-----I---------MEVTEVIEAIEATEV-------KNT-SDATNFSGV
TVVFENDDIIR--AKQEEKV-LENFLKPGCLRDTR-SKSEFKQ-----------------
---------TS--------------------------------------------K----
--------------------HVTISN-ITLTFKGERCFQTSLTPIKNETNIS---K----
--EMS-NETSEEMKTDFKNTAFKTESRKWSGILASVT--EF----ISCPL----KQQNFQ
CQSLIHSLNI--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKS-WWTSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGETN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRNWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-SRAPSINL---KSILPL-----
KFVE-LQIWDDQ--------ERVLRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILHKGLSITTKD---PTIL----VTHCLVPKSLCSPGGK-TEL-VQKKSKGLQ
PSESL--THLMAQGESETLSQIFS------------------------------------
--------------DLHQ------------------QKQYSSSRSEKMHI--N-------
KTSS--------------------EKATPCEDSIP--CT----------CDLNWRDAFMF
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLTGGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------N----NSLGKL
QRQLYNG-DYS-VFKD-----VPMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNSVQMVTVGITYTSPNLTI----PDV--------M
LLARPAVSC-AVNARH-------DRD----TSGRGF--KSTKSLEL---TRLLPL-----
KFVK-LSVYNYV--------KKQIHLKLATGRSFY-------LQLCPS---SDAKEDLFA
RWEDLVYLLRPPVEVYSGT---QAEP----AGDTM--DIPVLE-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKKNKN--K-SKKAMN--KQDTLFIPH-YYRLGHL
KNILDGG-EYA-PYVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPIF----KTPNM--------M
LLAHLTPEARKE-----------PEPL---FKTLLKS-SSSGTLVL---TRFIPL-----
QFVT-LSVHSAK--------NMRLKVKLINGRSYY-------LQLCAP---VYKQDIIFS
QWVDLIPLLNQEKIKNT--KVSEVSS-LSELTNST--DITGSMDI---T-----AFTELR
TRPPKTHRYPCNIMESADFSEYTDVTDITDVTDVTDILDNGV-TD---VQDIK-------
---------I-----V---------TEVT---------EV----SEVSEV-KMATNISGV
KIVFENDDIIK--TKREEKE---YTPKHRSLRDTK-TKGDYRD-----------------
---------SP--------------------------------------------N----
--------------------HATISN-IALALQDEGCFQTTLTPIKSKEDIY---K----
--EIC-DETSEENMIGLQNIHLKATESRSTRTDSDISD-GELK-----------------
----LGRYLHKQSSSREPPF--------------------THSPGSLSRG-SVFLPC---
----------C-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGLEL-----GVENGLL
CQLIHSP-EFN-LFSD-----SVVFES------NFI--Q---------------------
-V------------AK-PGNWKDVCERSTTVILGVTSSVPSLPL----PNV--------L
LMANVTSPRGP-------------------FSTWNTP-GDAPVITL---SRLLPL-----
KYVE-LQIYDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPETVFQ
FWIRLVKILQKGLSITTKD---QRIE----FTHCLVPKMPTSSMET--TS-ENSLLSTPQ
PSETL--MLLAAEQTNGSVSRLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIETG
NYRS--------------------Y-KIPSPVASP--IN----------LNIPMTAALSH
SLCDQEDP--HHFL-----------------QVPAASSLR--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTAQSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKIC-EEHARK-------GRF----AKGRGR--KPTKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPADSCSSA---PTVQ----TLDTT--------GDNRSL-------G---
------------------------------------------------------------
------------AAEL------------HGEGD---QSEV----G---LH-KT-REVSAA
SSS-AY---------AGGEGIQHASKACSKTA----------------------------
------------------------------------------------------------
----------------------------ARTASGMTTAGVATGP--GTGAKS-IAA----
-AK-SAGSG-QGTA-ALVGA-------------------------ATK-NQGESEASKGV
AGA-------TSV-SSDGINLALVGIASSSSAGTS--SLTAGAASLSQDS-SSSLVFASA
TA-TGAA---------AAA------------GPLVSTLQSDGYMSERDG-SQRVLQSHAE
ARK------DKKER--RHKKDRNT--SRKSSHHHRKG---------------------GE
KT--------RKASAHRSSSSPRNARD--------------------DKK--GKGHSHSR
-GKRHG-PSRKSSSHTAARKESRS-----SHKLVKSRSAGSAG-----TLSK--------
-KASKISSFLRSLRPSSTSKALV---------PLKDT---EVDILTKTVE-KRNIEAKVE
KAPDGKEVEVLS-SSVTSET-------------VEMIIFETKST----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------P--LVAALP----PRRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------C----LQL---LGLFPL-----
QYVK-LFVHDEN--------RQQLKVKFTTGRAFY-------LQLRAH---PESRESEFG
QWVR--------------------------LLYRL--RFG-----------------SAG
RDVPFTHEDL-------TPC---DSEEH---TEEV-------------------------
------------------------------------------------------------
--------------RAGGR---------------------------------------RF
GLWRND--WVEPGRWSGSWTCG-------SEE----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPSAV-RDPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNV--------L
LMANVTWPHGP-------------------FSTSST--PGAPVITL---SRILPL-----
KYVE-LQIYDRA--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKIPNSSTEI--TP-ESSLPSSSQ
ASETI--MLLAAERASDSLLGFSK------------------------------------
--------------RHQL----------------------TGDGHTD-------TTPVKD
KSN---------------------SCKTPPLMASS--------------TNMPMRATLTH
SLWEQEDPN-ENFL-----------------QVPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDTTNCSGV
TVVFENNDLIR--ARQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NTTSEEKTPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MDVYEGSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGQ-------------------FPSWSTP-DCAPEVTL---SRILPL-----
KFVE-LQICDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMSNSSTST--TP-ESSLPSSTQ
PSENF--MLLAAEQTSGSFSNISG------------------------------------
--------------RPQL----------------------TADSNTN-------VAIKID
NLDS--------------------Y-QTPARVVSP--VN----------LNIPMRAALSH
SLWEQENPD-EHFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKQGHEP-------KPAF------------
---------------GGAGEAGPGVM-----------AERP--LVPACP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKFRTGRAFY-------LQLRAP---PESRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
GPVPFTQDYS-------ALE---DDEDD---DE----DEDGD-LPA--------------
-------------------------------------GEL--QAM---------------
------------EARLDPQ---------------------------------------MS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKSNR--K-SPTRID--EKDDICVPD-SKDPGEL
QNMLNGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSPTI----KTPNV--------M
LLAHLTPTAQKD-----------SEPL---FKSLLTS-PSPENLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRIKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNKEKAKAS--KVSEVSS-LSEITNST--DITGSVDIMDIA-----AFPAIQ
TSHLSTCSNPNNDVESIDFSEFTDITDV---TDVTDIPENEV-TE---APDIN-------
---------I-----V---------TEVTEVTD---I--------------CEVTASSGV
RVVFENDDILK--AKQEEKEKMENILKSGCLRDTK-SKNEFRE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-LTLTFEGERCFQTTLTPEEDETDKS---K----
--EMS-NRPSEIRTMDSESTTLKAEESRYVKQGDANKNE---NQEC-N------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------LIPL-----
DLVH-LYVHDFF--------TWRLKLRLVTGRYYY-------LELEAP---DSEVAFLFD
RWIRLINLLREPATTWTPR---TMHT----P--PL--DVS-----------------LA-
------------------------------------EPPAST-WHLQDPPLCK---RTVT
VAQPSLPNKT--LTAQRQKKVK-----------ALKR-RFKSQAV-------------GD
SVPLIWSQLEHADVKKKSTEK--KPHSDVCADRSH-TQIHTS------------------
------------------------------------------------------------
--------------------------------------------EKTSITIR---T----
--IFSIISS----TINQAY------ASD-----SDEATGQRRL----LETPSHCLSDEGP
DFFFPGSHGHWHPHLWQANIE-----DLMDFESSTLSSASFSPASFPPAA-YLSTPY---
--------S-FPR-ASE------------KPRFVGSRQGRGP-----PA-SEKAPCVSAP
SYK------TPFVV---DR--SQKTPAD--------------------------------
----------P------TLSQKAPALH----------PPPWKALAVAGPS--QKVSTTPG
-PPQKAPHVLAIPPKTPAIPRSYWKDTPVLAVPQKAPPAP--------ALPQKAM---SY
PVPN----GGSGSSQKA-LTSPVQQHTALGSPTLSGKVPADFDIA----PAGIPGRDMLQ
RSKPEGKPEPVV---M------------AGTQEMNVVEMKTQTKALELPFS--TTKKKSE
EVVISKTQEMTMEGLRGWVKSEDRVHQAQ-EELSVELPGLRSKEMEQQKRWVKMKELAIE
GPPEEHRRPFSVEGLALQNDD------------HSQFQ-TAALETHFGLTSLLA-FSDFP
--CLYYANSGLN------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKRGHEP-------KPAF------------
---------------GGAGEAGPGVM-----------AERP--LVPACP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKFRTGRAFY-------LQLRAP---PESRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
GAVPFTQDYS-------ALE---DDEDD---DE----DEDRD-LPA--------------
-------------------------------------GEL--QAM---------------
------------EARLDPQ---------------------------------------MS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGFPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-VPSWR-S---GPVTK-PGNWKDVCERSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FSTWNTP-GDAPVVTL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPETVFQ
FWIRLVEILQKGLSITTKD---PRIE----FTHCLVPKMPTSSMET--TP-ENSLLSTPQ
PSETL--MLLAAEQTSGSFSWLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIETG
NCRS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSH
SLWEQEDPR-EHFL-----------------QVPAASSLG--------------------
----------------------------------EHFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------R-----AAMRR--LWHF-IFPPPP--PEPPKW----VPILGEM
QKTLQMA-EYL-PLRP----L-PMFES------NFT--Q---------------------
-VT------------N-NGTPALLHNKSNKLTMGVAASLPGL----VLPDI--------L
LIARPPE--D----------------------------QESSSLIL---TRMIPL-----
DLAR-LYVHDLP--------TWRLKLRLRSGRHYF-------LALDAP---EHELAFLFD
RWIRLINMLRGPKLSRTPK---T-------ERSLL--EVP-----------------PE-
------------------------------------VTPAST-WHFQVQSQGK---LTVE
VADPTFPCKI--FSSHKPKKTKMKLT------KPIKH-SLRSQAV-------------GD
SVPLIWSQLQSSEDQMNVTKN--KSYLHGRSDRPE-PLIHVS------------------
------------------------------------------------------------
--------------------------------------------DKASLTIR---T----
--IFSIISN----TINQAH------KSD-----SEEDASQGRL----LETPSRCISQNDT
SFPVVVASDHLNTLLWAQNLD-----DLRNPEFATLSS---LSTSYPPAF-YIFPPN---
--------PPFPK-SKD------------KARPTGSKRHVSP-----PP-SHKASSVPIE
SRK------MPFIL---DQ--SNKVPAE--------------------------------
----------P------APAQMASALPSPSRK----------TPTALWSR--GKSSAAPG
-HVYKSQPS--VSQKTPTTPGYPWKPQVITAPSQKTLTPNQKL-LQVPTHSQKAM-----
-HPKKDHLLVNAPSQKD-PTAPYQK-----ALDSWAKAPGDPRTL--------QGGDML-
ERKTEGTQEPVL---L------------VEQQSTMVVDVRAQTMPLHLPFA--TTKKQSK
EILIGKTQ----EALKGREKLEDRAHNME-EETTVNLPNLKSKETEMQ-KWVLTEEIAVE
SPYREDSRPFSAEELALAKMKIMANS---KHQ-QLKPA-TVSLPSSFSMTSNVSSMSMLA
--NLPFNTSRMTFPDGSQVVVIEQSGSHTKVNKENTWHQMERKPAEDLPVNSNP------
----------------------RI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEDCCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
VLARPAAVC--DNARC-------GPA----TQKRDS--LPAEILEL---TRLLPL-----
MFVK-ITIHNSV--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---RAIL----AGNTL--DSSVLEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MVTNSESPLPC-YAAKSG--FVATIFG----TSIGKL
QQHLHKG-EYY-MFRS-----TLMFES------DFV--Q---------------------
-IT------------K-SGELIDVHNHMNLMTMGVACTSPILPIPTQIPDV--------V
LLARQATSC-EQCHSQ---------A----PKRKKC--KAEEPLEL---TRLLPL-----
KFVK-ISVHDRK--------KQQLHLKFATGRSFY-------LQLRGP---LDACEDLFT
CWESLIDLLQPPFESISGT---YATP----AEDIL--CLPALADADRAS-------LAAS
DAHSRDYWDQVSIH----------------------------------------------
-SVHSDLEVTGATSDD------------HGRDY---WDQV-SIRS---VH-SD-PKVTRA
TSA-AY---------ASGEGDQPSSRTSTGTPKVYTPKTRSGGSA-EE-SAPGTKRE---
------------------------------------------------------------
---------------------AA-----------------AA--RVASGVPS-V------
------EAS-QENT-ALPEA-------------------------AFI-GEGGSK-----
----------------------------------------------SPVA----------
-----------------------------------------GP-GGAKAGQQGTPKASKA
SRK------EHRER--KE-RREDRPLSR-SSYHRRTR---------------------EG
HHKTEGDKMAQKSSSRS-SSGHRTHRV--------------------NKN--EGGHLRAK
-SSRHS-HSPKGLSHTRLEKEPRS-----SNKSRRSLSAVSSE-----STPK--------
-RLSRFSSFLENIRANLGMKGAA---------SLHGG---KVDTVPKRVE-ETDLEATAE
MAEFGQGVE-V--DSETSMV-------------KKKVTFRSPLPSTHSQKPQRAPGAPQQ
SLL---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKSDR--K-PTTRIN--EQDALSVSH-SQGPGDL
QSMLDGG-EYD-HFIS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYVHNRANWVTVGICSSSPTH----KIPTV--------M
LLAHLTPTVPKD-----------KEPL---LKSVLTS-PPTEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---ACKQDTLFS
KWVDLISLLNQEKAKLS--KVSDVSS-TSENTNST--DITGSLDIMDIQA----AFTAMP
SLYTHAYSDPV-VVDSIDFSEFTEITDI---TDVTDIPENEI-PE---VSDVR-------
---------I-----F---------TEVTDV------TEV-------TDF-SDATHFSGV
TVVFENDDIIR--AKQEEKEKRKNILKPGCLRNSK-SKSELKE-----------------
---------PS--------------------------------------------K----
--------------------HVTISN-ITLTFEGRRYFHATLTPGESERTIC---K----
--EMS-EKSSEVKMTDFQNPALNTMGSR--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKS-WWTSK---KTVKV
IRSYPTFP-------------SLNAWEKFRGL-LPVDGETN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRNWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-SRAPSINL---KSILPL-----
KFVE-LQIWDDQ--------ERVLRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILHKGLSITTKD---PTIL----VTHCLVPKSLCSPGGK-TEL-VQKKSKGLQ
PSESL--TRLMAQVESETLSQIFS------------------------------------
--------------DLHQ------------------QKQYSSSRSEKMHI--N-------
KTSS--------------------EKATPCEDSIP--CT----------CDLNWRDAFMF
GEWERENPS-GPQP--------------LSLLSTLAASSRPR------------------
----------------------------LSLTGGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNDPVMLPY-YTAQSS--PAMGMFN----TPMGKL
QQQLYKG-EYA-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-SGEVIDVHKRAQMVTVGIVRTSPCLTL----PDV--------M
LLAQPAATSGDNSARC-------GPA----TQERGS--KPTPILEL---TRLFPL-----
KFVK-ITIHNSI--------KQQLRLKLITGRSFY-------LQLCCP---SDT-TDLFV
HWENLIYILRPPMEAYSST---QAML----AESTL--GSHVLEEEHRSP-------VA--
------------------------------------------------------------
------------YAMK------------FCDR----NDQF-SIRR---LR-TN-TEVFRP
TYF-HY---------GRET-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSLPPRKA-WWKPK---KTVQV
IRSCPTFP-------------SLNAWGKFRGL-LPVDREPN--PGVGL-----GVEEGLL
CQMVHSQ-EFN-LFPN-----SAVFES------NFV--Q---------------------
-V------------KK-GRNWIEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-STAPHIIL---KRILPL-----
KFVE-LRICDRI--------ERVLRLRTLTEKIYY-------LKLHPD-----HPQTVFH
FWMRLVQILQNGLSFTTKD---TSIL----VTHCLVPTSLCSPSGE-SEV-R----KSSQ
PSESL--MQLMAKGESEALSQIFS------------------------------------
--------------DLHQ------------------KNQFSSSISDKLHS--M-P-----
--LF--------------------TKATCREDNIP--CT----------IDLSWRDSFTY
GEWERENPS-GPQP--------------LSLLGTLAASTRPW------------------
----------------------------LALPIGMVV-GFIEGPSWASLEFK-LRT----
-RTMS-PPG--DSR-----I----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKLC-EEHVIQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTA-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAM------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------DKKE---REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKVVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEVGFLFH
CWVRLINLLQEPAPTWTPR---TTRT----A--PL--DMP-----------------LA-
------------------------------------EAPAST-WHLQDQPISR---HAVR
VAERNFPHKT--VAAQRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHSDPRPDRTH-TQIR---L----------------
------------------------------------------------------------
-------------------------------------------PEKTSITTW---T----
--IFSIISS----TANQTQSSPKACTSA-----SDEATGQGHV----VESPSHCVSADSP
DGFFLGSCSSLDPCLWHQDTE-----DLMDSGGSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KAGPMGSHQGPGP-----PP-CQKAPSGLVT
SCK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPS--QKAPAVPA
-PSQKAPAIPAPSRKASAASASPRKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKKKSLLLPAPSQKALPTSPTEYQMALSPPASRGKLPGDFDVL----PTGIPGRAVLE
RSQSGGKPEPVV---T------------VRTQETDVVEMTTQAKSPESPFT--VTKKESK
DILISQTKEVTLEAFRGQGKLEDWAHWAKLEERSPDLPGVRSKELEQRKRWVKAKELAVE
GPSQEHSRPFSVEALTLTKLMITANS---KEQ-PSKSA-LVSLPSWLLATPQASATSMMA
--SVPSRPGQLSLLEGKPVVVREQPESHTWVKEGKRPWGEMKEQPWGEMKEPPWDPKGP-
PKVPFRSKPTSASLKREGISQAPIPLTASPWEDL--RPSP--LSETLISKMEATARASQQ
PKRVSQEPM-----------------------------------------RMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLLPSLQHSQHSEWPDAGA------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GSA----TQNTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLIYILRPPVEAYSGT---KAIL----AGNTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------LCKE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------LEERSY-YSAKSS--LAMGMFN----TSMGKL
QRQLYKG-EYP-IFQY-----APVFES------DFI--Q---------------------
-VS------------R-KGEVIDVHNRAQMVTVGIVRTSPHLTL----PDV--------M
LLAQPVAIC-DDSNRH-------GPA----AQKRGK--KPTQILEL---TRLFPL-----
KFVE-ISIHNSK--------KQQLRLKLATGRSFY-------LQLCPP---TDR-GDLFI
QWKKLIYILRPSVNAHSRA---RATP----ARNIL--DITGFKKREEVP-------SG--
------------------------------------------------------------
------------KYQK------------DGAR------------V---LR-EN-S-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MKKNR--K-PTSRID--VQNALCVPH-PHGPGDL
QNMLDGG-EYT-LFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTC----KTPSV--------M
LLAHLTPTVPKD-----------TEPL---FKSLLTS-PCTEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---AYKQDTLFS
QWVNLISVLNREKAKVS--KVSEVSS-LSEITNST--EITDSMDIMDIT-----AFAAVQ
TPYTHVCTGPVHVMESIDFSEYTDITDI---TDVTDIPENEI-TE---VPDVR-------
---------I-----V---------TEITDV------TEV-------TDN-SDATHFSEV
TVVFENDDIIK--AKQEEKEKMKNILRPGCLRNTK-SKNEFKE-----------------
---------SS--------------------------------------------K----
--------------------RVTISD-ITLTLEGTKCFRTTLTSVESKVNIC---K----
--EMD-NKTSEDKTTDFQTAALKAIESRSMSIDSDSTAL---SPHIKS------------
SSNFLNVVPHLSPP-FSGER----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------MAGERRS---Q-------ARKGRL--PVPACA----PEGPGWL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPTKEDG----------------------------C----LQL---HGLFPL-----
QFVQ-LFVHKES--------RQQLKVKFCTGRTFY-------LQLRGP---AETRDLEFS
QWVR--------------------------LLYRL--RFY-----------------SGQ
GAVPFTHSRP-------APH---CESPS------AGSETLSP-TQ--L------------
--------------------------------------Q----VR---------------
------------EARLNPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MCS----RPLS--------
------------------------------------MCRNVISST--WKDLEEIKEDSKS
HKILSNLP-------------FPECLGRIQGP-LSCGSRAE--PWSGP-----RCGGG--
--TALPG-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWRDIYKASYTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRILPL-----
KFVE-LQVCDHH--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKV-SNHHCQPPA
KARAV--R----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-THTPEAD---FQVTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-VDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSIET--TP-ENSLLSSPQ
PSESL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KLQL----------------------TADRNND-------TAIEID
NRSS--------------------Y-KIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MLPL-----
DLAH-LYVHDLS--------ACRLKLRLVTGRYYY-------LELDAP---DNELGFLFD
RWIRLINLLHEPATTWAPR---TLST----P--TM--GLV-----------------HV-
------------------------------------VPPAST-WRLQAQPQSK---RSVM
IAKPTFPYKL--MASQRQKKTK-----------TLKR-RFKSQAV-------------GD
SVPLIWSHAEHAQAKKKPTEK--S-QPKLYLDTSQ-TKIQVS------------------
------------------------------------------------------------
--------------------------------------------EKPSITIR---T----
--IFSIISN----TINHGH------SSD-----SEVGTVLGGL----VETPVRCISEDSQ
EPSLVGSYDCLDAYLWQQDVE-----DLMDPDTSTLSSSSFSPAPGPPAF-YFPHAL---
--------PSGRK-HKE------------KAG-----QRPRP-----LR-SQKSPSTRAT
SSR------VPFIL---DQ--SKKVSAV--------------------------------
----------R------APSQKTSAAPGPSRRVPTAPGAPQKVPTAP-------GP----
-PQKKAQAIPAPSQKPPPMLASPQKPPAVPFLSQKSPPTL--------ALPPK---AVSP
TLQRKKSLFIPTPSQKA-VTSPSQYKMTPER--------ADFGLG----PKIGPRRDVAE
RRKQEGAPQPML---F------------VGTQEMDVLETRTQKTSMELPFT--TTKKQSE
EVVISKAREITLDGLKGRGLLEDKVHRKK-EKISLDMPGFRSKERGERHRWLKTQELAIE
GGPEEQSRPFSVEGLTLQDDDHGQLQGAPPETSCSRPA-LLAL----SSP-GI-YVSRGY
--RAL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNR--LWNI-RRMEPF--QGPAKW----VPTLGEL
QKTLQKG-EYM-PLRP----L-PMFES------NFV--Q---------------------
-VT------------S-RGAPAYVHHRANLLTMGVAASLPGL----LLPDL--------L
LIAQPPE--G----------------------------RECSNLVL---TRMIPL-----
DLVH-IYIHDLS--------AWRLKLRLVTGRYYY-------LELNAP---DKEVGFLFD
RWIRLIHLLRGPATTWAPR---PLHV----P--PT--DLA-----------------HA-
------------------------------------APPAST-WRLQVG-----------
-----P------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTAHSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARL-------GRH----IKGKGR--KPIKILEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPAESSTTT---PVMQ----TADMV--------EDNRTS-------M---
------------------------------------------------------------
------------ASEI------------RGQGD---RNEV----G---HR-KA-FGVSAA
SSS-AY---------AGGEGIRHSPRHKASAVASASSPKARAIPL-AS-SPKASAVS---
------------------------------------------------------------
-----SATSTKASAVPSAMSTTGTAAGAAGIASGTTVAG-VTSP--ATGTLS-VAT----
-IK-PTGPG-QVTA-AVAGT-------------------------ATK-NPGESESGKTI
AGA-------ASI-SSDGINLALVGAMSTSSAGTS--SFTTGTSNISQESSSSSMVFAGT
MM-TGTS---------EAV------------GPLVSTLQSEGYMSERDG-SQKVSQPRAE
AQK------EKRER--REKKDRHP--SRKSSHHHRKG---------------------GD
KSRKGGDK-SRKTSSHRSLSGHKNVRD--------------------DKK--DKGKSSAR
-DKRHS-STRKSSSHTTTRKESRS-----SHKLGKSRSASSSG-----TLSK--------
-KASKISSFLRGLRAPSGSKVTV---------TSADR---EVDIMTKTVE-KHNIEAKVE
KAQEGEELGRIS-GTMTSET-------------TEMIIFETKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDALCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TETL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDME--------NMRLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMDVTDVT-----AFTAIL
TPYMYAGTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPAESEANTS---K----
--EME-DKTSEEKMPDFQSTALKAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLFAP-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MAP-----AVMRR--LWRF-FFPPPP--PEPPKW----VPILGEM
QKTLQMA-EYL-PLRP----L-PMFES------NFT--Q---------------------
-VT------------N-NGTPALLHNKSNKLTMGVAASLPGL----MLPDI--------L
LIARPPE--D----------------------------EECSSLIL---TRMIPL-----
DLAR-LYVDDLP--------TWRLKLRLRSGRHYF-------LALDAP---EHELAFLFD
RWIRLINMLRGPKLSKTPK---T-------EPSVL--EIP-----------------PE-
------------------------------------VTLAST-WHFQVQSQGK---LTVE
VADPTFPCKI--FSSHKPK-TKMKLT------KPIKH-SLRSQAV-------------GD
SVPLIWSQLQSSEDQMQVTKT--KSYPHACSDRSE-PLIHVS------------------
------------------------------------------------------------
--------------------------------------------DKASITIR---T----
--IFSIISN----TINQAH------KSD-----SEEDTSQGRL----METPSKCLSQNST
GFPVTVSSNQLDTLLWAQNLE-----DLMNPEYATLSS---LNTSHPPAF-YIFPPN---
--------PSFLK-SKD------------KARPTGSKKHVSP-----LS-SHKAACVPIE
SRK------MPFIL---DQ--SNKVPAK--------------------------------
----------P------APAQMASALPTPSRK----------TPTALWSR--GKASGALG
-HFFKSQPS--VSQKTPTTPGQPLKPQVITTPTQKTLTPNQKL-LQAPAHSQKAM-----
-HTKKDHLIVNIRSQKD-PTAPYQK-----ALNSRAKASGDPRTL--------QGGGVL-
ERKTEGKQEPVL---L------------VGGQNTTVVDVRAQTMPLHLPFA--TTKKQSK
EILISETQ----EALKGREKLEDCAHKMK-E-TTVNLPNLKSKETEMQ-KRVLTEEIAVE
NPYTEDNRPFSAEGLALAKMKIMANS---KHQ-RLKPA-TISLPSSFSVASNVSS--MLA
--NLPFDTSQTTFSDGSQVVVIEQSGSCTKVNTENTRHQMERKPAEDLPVSSNP------
----------------------RI------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRKS-WWTLK---KTVKV
IRSYPTFP-------------SLNAWEKFRDL-LPVDGETN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------RR-SRNWKEIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------SQTWNRP-SRAPSINL---KSILPL-----
KFVE-LQIWDDQ--------ERVLRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILHKGLSITTKD---PTIL----VTHCLVPKSLCSPGGK-AEL-VQKKSKGLQ
PSESL--THLMAQGESETLSQIFS------------------------------------
--------------DLHQ------------------QKQYSSSRSEKMHI--N-------
KSSS--------------------EKATPCEDSIP--CT----------CDLNWRDAFMF
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLTGGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------PSPTFDFLLRLLPTFGSRGGGVAMKRGHEV-------RPAL------------
---------------SGAGEAGPGGMA------------------A-YP-----GRPGRL
QRHLLSG-EFD-QLRD-----FTIFES------NFV--QFCSPSILSLI------SDLWP
QVT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPGKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RCQLKVKFRTGRAFY-------LQLRAQ---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------SVQ
GPVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------I-------RAQTTS--VPTGCP----DFGMGDL
RRCLASG-EYG-GLKD-----CPLFES------NFM--Q---------------------
-VT------------K-TGD------VANRVTVGIAATSPTL----EMPDL--------M
LLCTANP--S----------------------------LSYKELQL---FGLLPL-----
KFVR-LYVHDES--------RYQLKVRLANGRTFY-------LQLLTH---PLKQDEVFG
QWIR--------------------------LLYRL--RFY-----------------HTD
APLTYEQ-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNNESCLPY-YTAHSY--CSMNVFR----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGDVIDVHNRVRTVTVGIVCTSPILPL----PDV--------M
LLARPAKVC-EEHARQ-------GWF----AKGRRC--RPPKTLEL---TRLIPL-----
KFVK-ISIYNHE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFS
YWEKLVYLLRPPVESYSST---PTLL----SGDTAP-------KDSESL-------L---
------------------------------------------------------------
------------AAEL------------HRKGN---RSET----G---LH-KP-CDVSAA
TSS-AY---------AAGQGIRYASHGMASATSLNTSTAGAAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGV--AGTTTGPRAGVAIAGAAMSP--ATGAVS-IAA----
-TK-PAGPD-QVIT-VLAGA-------------------------TIK-NPGENESSKSM
AGA-------ANI-SSDSINLALVGVASPSSAGTS--TTMAGAASLSQDN-SLSTAFAGS
MT-TGKCVAERTQ--GPAL------------GSLVSTLQSEGYMSERDG-SQKVSQPSAE
AWN------EKKER--REKKDKRP--SRKSSHHRKAG---------------------ES
HRRTAGDK-TQKASSHRSISGHKNTRD--------------------GKK--EKGRSKVR
-GKGRG-SSRKSSSHSSTRKELRT-----THKLGKNQSTSSTG-----ALSK--------
-KASKISSFLRSLRATAGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KA---QELEVTS-GTMTSEM-------------TEVIVFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSIPHRKT--WKSK---KTVKV
TKSYPTFP-------------SLNAWEEFRGL-LPVDAELN--SGVAL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KK-GRNWINIYKVSKTMALGVTSSVPCLPL----PNI--------L
LMAS-----GQ-------------------SQTWNRP-AIAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QGILRLRTVTEKMYY-------LKLHPD-----HPQTVFH
FWIQVVQILKEGLSITTKD---PRIL----VTHCLVPKNNCSSSED-SKL-VQKKLQASQ
PSESL--MQLMAKRESEALSQIFE------------------------------------
--------------DLHQ------------------QKPFRSSK--KMN-----------
KACS--------------------EKDPPPKDDIP--CT----------HDFSWRESLTY
GEWERENPS-GPQP--------------LSLLSTLAASTWPR------------------
----------------------------LAPPIGTSR-GPIRLP-EDSLEFH-LRA----
-G--S-GLE--VLK-----VMPECSGLGV--GXXXXXXXXX-XXXXXXXX-----XXXXX
XXX--------------GKAVTLSVFLPCSLIHQ------G-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSR-----------------
---------------------IKKTMSSECLPPY-YTAHSY--RSMGVLN----TSMGEL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPILPL----PDV--------M
LLARPAKVC-EEHVRR-------NRI----T---GRR-KPSKTLEL---TRLLPL-----
KFVK-ISIHDRD--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFS
YWEKLVYLLRPPVESCSSA---PTLQ----TGDIPI-V-----DDIKSQ-------T---
------------------------------------------------------------
------------SSEL------------HGEGD---QDS-----G---PR-KC-GELSGA
SSS-AY---------AGGERIPPGSSTLVAPSSTRPVSAGTAGPT-YS-MA---------
-----------------A------------------------------------------
---------------AGSRAG---------STASLAMVGSSTST--ASCAGS---LS---
TTK-HPGSG-HLTA-AVAGS-------------------------ASK-ELKGGGVGKTL
AAA-------TTVGSSEGVNVAVAGTASTSSVDVS----TAGVTSRSADS-SLSVVFAGT
ML-TNAPEEKKGKVEPSAA------------PPLVSTLKSEGYMCERDG-SQKQ---GPE
IHK------EKREK--REKKEKTT--SQKSSHHHRTSES---------------------
HHRVSKDK-PRKSSSHKSVSSHGHKKE--------------------DHKKPPKGQSTVR
-GKRRGRSSSAK--------ESKP-----AHKPRKTRSGGATG-----ASGK--------
-KPSKISSFLRNLIAIPSSKTMV---------SSHNR---EVDIMAKKVE-KCNIETKVE
KG---QEGQ---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGKGC--KPSKTLEL---TRLLPL-----
KFVK-ISVHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPMTNCISN---STLP----TGETSV-D-------TKST-------L---
------------------------------------------------------------
------------VSEI------------RGEGD---QNS-----R---PQ-SS-PTVSEA
TSA-AF---------AGGERTQPAAAAAVTPVSAKARAAGTAGAA-AG-TAGA--AAGT-
A---------GPAAGPAAGTAGPAAGTAGAAAGTAGAAAGTAGATAGTAGATAGMAGATA
GTAAETAGTAAETAGAARAAGGPMAAAVAAPSAGMTKAETATSP--TSGVIS-LAAT---
TTK-PPGSG-QVAA-AMIGS-------------------------AAK-DQVGGESSKAM
ALA-------ANI-TLENVDVALAGAANSISESPP----AGGDASGSPDT-GLNVAFAGS
IK-TKSPAEDK--PE----------------APLVSTLQSEGYMCERDG-SQKVSQTSSE
A-K------EKRER--RE-KDRTS--SRKSSHHRRTGMS---------------------
RHS-SKDK-SRKTSSYRSVSG--KTRE--------------------D-K--GKGHGRLR
-GKRHSS-SHKS--------ESRT-----GHKTRKNRSPAGLG-----SVSK--------
-RATKITSFFRSFLVRPTPKAGD---------TSCDR--GGVDIVTKLVEKKQDIEAVME
KS---KDSE-FK-DTVISET-------------MEKIILETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MATKEESLLPY-YTAQSG--AEVGMFNGLFDTATGKL
QQQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------R-YGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAP-F-DELLGH-------GQAT-SSIKGKKR--KAGKTLEL---TRLLPL-----
KFVK-ISVHKRD--------QQQLRLKFATGRSCY-------LQLCPP---PESKDDLFS
YWEKLIDLLRPPVDSNTST---YAIP----AGDMM--STPFLDEELKIP-------KKKG
------------------------------------------------------------
----------RRKSGH------------RRKRD---LYKI-SIKS---LP-E-ATDMSAI
SSS-AF---------AGGEGI-YDSHISTIVSRIPTPKVSSKVLA-RE-SA---------
------------------------------------------------------------
-------------------------------------SEAIV--CDLVDSLS-LAAN---
--M-PEVLG-QINK-ATVGE-------------------------AAV-GARGSKSHLTI
ARA-------GKM-SPKSMKIALAGMASKSLEYI---P--SSPASLSRKE--MTIANSRI
ET-TGKSVGETAN--DPVP------------VVLALTLPSESHSSEETG-CRKAYETNTK
AHK------ERRSR--RDQRAKERVGSR-SEQHQRTG---------------------EG
H-KTAGDKEFQKSTSHR-GVG-----D--------------------DKK--------DK
-GSKRN-RWHKGVSHVPITKESRS-----SHKLSRTISTASSA-----SASK--------
-RMGRISLFLRNIRASLGGKSLA---------P-RGQ---DVGIMTKTLE-TTDVKAIME
A-ENGQGLE-II-DSVTSQV-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MGPPLWPDLQEPPPPGTSSQ----------T-RSPLLCDVIKPAP
HHDVTVRVVPSPRFLPLLLRPLPS-DGDIAMRRDRGP-------KPAL------------
---------------DGAGEVEPGGMA------------------A-SP----TGRPRRL
QRYLQSG-EFD-QFRD-----FPIFES------NFV--QFCPHIYPAPT------SDLWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLEVKLNTSRTFY-------LQLRAP---LKTRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
STVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSDCLLPY-YTAKSG--SGMGMFN----TSMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPSLPL----PDV--------M
LLARPATGC-EEYGGH-------GQS----TKGRKR--KAAKALEL---TRLLPL-----
KFVR-ISVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LDARKDLFA
YWEKLIYLLRPPVDSNSST---YAVP----AEDM---CMPVFEEDRT-S-------L-G-
------------------------------------------------------------
------------GADL------------QGKGD---QDQV-SIRS---LQ-IV-SEVCGA
TSA-AY---------AGGEGVQYNSYKPIGVPDASTPKTKPMDFA-KE-SATG-------
------------------------------------------------------------
-----------------ATAEVAVAG--------------AA--AGTAGALS-LAGT---
------KFG-DAS--SIAGG-------------------------AVL--R-GSKSNIAI
AGT-------ASM-SPKSIKVAVAGAASKTSEHI---S--GASTNISPED-TMSVAIAEI
EP-TSKTVGERDN--CPAE------------EPPVSTLLSESSASGPQGRRH--AHASAE
--R--------RGK--RERREKDRALSGRSTHHRRTG---------------------EN
RRKTSRDKIARKSSSRS-SSSHRASRE--------------------DRK-EKRRRSSPG
-DSKTR-SSHKDVSHTLITKESRT-----SHKSGRSVSTTSSG-----S-RK--------
-RLDKIGSFLRNVKANLTTKGGG---------SPRGR---HVDVVAQTVE-KNTMEAIVE
AGESGQELE-MV-GSVTSEI-------------KETVTFTAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---MQTSRAALHCPRLGPGSDSPIGAPR-MGPCVSAEVT--------KPPLGS-S-----
-------------PTGPWPRPVSPTPGEAELQGPRP----------AAWVGWEWGP-WVV
DPWMGTLPTP-----APA-----AIMKC--FWNT-RPAQPL--QGSQKW----VPVLGKL
QKTLQKG-EHL-PLRP----M-PMFES------NFV--Q---------------------
-VT------------D-AGSPVLMHHSANRVTMGVAASLPGL----VLPDI--------L
LVARP-Q--A----------------------------RDGSCLEL---TRVIPL-----
DCAR-LYVHNVS--------ARRLKLRLVTGRCYY-------LALEAP---DPELGFLFN
CWVRLAHLLREPATARPPR---PPHP----P--GQ--DAL-----------------LA-
------------------------------------TVPAST-WRLQDLAHSS---CTAA
IGEPAFPPKK--LSIQKSRKAK-----------C----RLQSRAV-------------GD
SVPLLWPKHECADLRMKPAGK--RSARSANTDRCA-IQIHDP------------------
------------------------------------------------------------
--------------------------------------------GKPSITIR---T----
--IFSVISS----TVQQ------ACAPD-----SEEAPGREGL----IATPSRCVSPASC
SLSPLGSYDSWETLLWHGDIK-----DSLVPEASTRSSSSSGKAPPSPAL-FVFPPC---
--------PSFPS-PRD------------KARDADLQVGQWP-----PP-SRKARSGAGP
QQR------APGIT---EQ--PQRVPAV--------------------------------
----------P------APSWKTPTVSAGPQK----------SPAAPHSS--QEAKAVLS
-PPYKPPPQ------------------------------ALTA-PPAHTGPQK---AACP
PAPEKQPLLLPSWVQQV-PAPPPRPRAAPSRPAFQGKPPAQLDKA----LAGLPGADVTE
KNKPQRTGVHGV---L------------VGAQETNVIDMRTQKVSLDLPFT--ATTKQSK
EVLLSQTQEVTRGALRGQAKSEGTACRRT-EAPSLGLPGARSKEEQQQKSRERTQQVAIK
APERECSRAFSVEGLMMAKLMIMGSS---REQ-CPRPP-GASRPSWLSGTSRAAATSVDG
QVSLPLNPSRLSLLEGTQVVVRGQPKPHPWVKEKAQQQRAREPPSAGPSKG---------
---ALGSVPGSDSP-LAADPLVPIPLPASLWEDMPQPPLPPAS----SSGAKAPARAPQQ
FSRAPQGPP-----------------------------------------RVPRQRP-AM
TGSSSEGVLPVLLEIQSVREAATKAQMTKGDLSFLHPLARCVEP----------AIRACC
QLCYPPEGGAGSRRSLSHLCPDGWTALVALGVGSGKHRF----------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEDCCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTMGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKRES--PPAEILEL---TRLLPL-----
MFVK-ITIHNSV--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSDT---RAIL----AGNTL--DSSVLEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYC-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGSRKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKTPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPQRKT-WYKLK---KTIKV
TRSYPTFP-------------SLNAWEELRDL-LPVDQEPY--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KK-DRNWIDMYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STVPNIIL---KRILPL-----
KFVE-LQICDRP--------QRILQLRTVAEKIYY-------LRLHPD-----HPRTVFH
FWIRLVQILQTGLSITTKD---PRIL----VSHCLVPKNSCSPSGD-SKL-VQKKLQAPQ
PSDSL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------HNQFSSRSS----K--K-TDTKKD
-S-S--------------------EKDTPSEDCIP--CT----------RDLSWRDSLTC
GEWERENPS-GPQP--------------LSLLSTLAACTRPQ------------------
----------------------------LTLLIGTVM-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIR--LRNR-RRPELL--QGTPKW----VPILGEL
QKTLQKG-EYL-PLRP----M-PMFES------NFV--Q---------------------
-VPSSHPYVGGSQEGG-SGGPVFVSHRTNRLTMGAAASLPGL----LVPDI--------L
LIGQPAE--G----------------------------RDYSGLVL---TRMIPL-----
DLTQ-LCVHDLS--------SWCLKLRLVSGHSYY-------LALDAP---DNEAGFLFD
CWIRLIHLLREPAFTWAPR---TVRA----D--CL--DMP-----------------LA-
------------------------------------EAPAST-WHLQVGPQLH---QPAR
VAEHTFPYKT--VATQRQRKAK-----------PLKR-RFKSQAV-------------GD
SVPLIWSQLEHA--RKKPAEK--KSHPEPRPERPH----TQTHF----------------
------------------------------------------------------------
-------------------------------------------SETTSITIR---T----
--IFSIFSS----TTNQTQSAPKACTSE-----CNEATGQGHM----VKAPSHCISADSP
DCFFLGSCNSWDPCLWHQDMG-----DLMGSESSTLSSASLDLAPCPSAA-CLSTLY---
--------SSIPR-DRD------------KAGPMGSQQGPGP-----PP-FQKAPSVPAT
SCK------APFLV---EQ--SQKLPAA--------------------------------
----------P------ASSWKAPAVSGPPQKAPAIPAPPGKAP---------------P
-LSQKAPAVPAPSQKAPPPS---QKAPAVPAPSQKTPPPSSQKAPTVPTIPQK---AVSP
PAPKRKSLVLPAPSQKALPTSPTQYRMALGSPASQGKIPGDFDAL----PTGIPGRAVLE
SSKSGREPEPAV---V------------VGTRETGVVEM-TQALSPEWPFT--TT-KDSK
DILVSKTREATLEAFRGQRKLEDRVHWAK-EERSLDQPGVRSKEMEQWKGWMQTKERAIG
GPSREHSRPFSVEGLTLARRMIMVNS---KEQ-GSRHD-LVSLPSWLSQAS---GTPMMA
--SVPFHSSQRSSLEGKPVVIREQPESHAWVKEREQQWAKAKEPPWDPEGL---------
PKLPLRSRPTSASLKREGISEVPIPLPASRWEDL--LPSP--LSETPVTKTEAAARTSQQ
PRRVSQEPL-----------------------------------------TMPAQHPLAT
VGSSSEILWPVLLELETVRNTTTKAEETQEEAGVSSLPPR--------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MVTNSESLRLPY-YTAKSG--SAAGMFN----TSMGKL
QRQLHKG-EYD-MFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNSVRMVTVGVARTSPILLI----PDV--------M
LLARPAANW-EELQGH-------GQA----SKRKKL--RAGKPLEL---TRLLPL-----
KFVK-ISVHDHE--------KQQLRLKFATGRSCY-------LQLCPP---HDAGEDLFT
YWEKLIYLLRPPVDSNSST---YATP----AEDML--CMPALAEEDRAS-------L-A-
------------------------------------------------------------
------------SPDA------------QGKGE---QDQV-SIRS---LH-LV-PEVTRA
SSA-SY---------AGGEEIQSCSHRSTATPTKSPKVLAPGPKG-EA---AA-------
------------------------------------------------------------
---------------A-GAA----------------------------------VAA---
--G-TSGSG-QVST-ALAGA-------------------------ASL-GVGG--GRSPV
VGT-------GKT-SPESMSVALAGAVGLFSEPV---S--RAGSCFSPED-SMSAAFAGG
EA-TSKDTGEAAN--ALAVR----------------VMASAGP-GGAEAGQQGAPQASKA
TRK------EHRER--KERREKDKPVSR-SSYHHRTQ---------------------ED
RHKTEGDKMARKSSSRV-NK------K--------------------EK-----------
-GSHHS-ARSSRDGRTPLGKESRT-----SHKSGRSLSTKSSV-----STPK--------
-RIGRFSSFLRNIRANLVTKGAA---------SLRGG---DTDIVSKRVE-KTDMEAVME
TAEHGQGVE-VI-HCVTSEI-------------IKTVTTEAS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNADFLLPY-YTAQSG--SSMSMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-KEYAGH-------GQA----TKRKKR--KAAKNLEL---TRLLPL-----
KFVR-ISVQDHE--------KQQLRLKFATGRSCY-------LQLCPA---LDTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WVPVFQEDRR-S-------L-G-
------------------------------------------------------------
------------AVNL------------QGKGD---QDQV-SIQS---LH-MV-SEVCGA
TSA-AY---------AGGEGLQNDFHKPTNVLNVSIPKTSTE-LA-EE-P-AT-------
------------------------------------------------------------
---------------G-AIKEAAAAG---------AAAGAAT--GTVAGALS-VAAA---
--N-SA-PG-QVST-AIAGA-------------------------ATI-SAGGNKSNMAL
AGT-------ASM-APNSTKVAVAGAAGKSSEHV---S--SASMSLSREG-SVSLAIAGV
VL-TSRTAAETDM--DAAA------------GPPVSTRQSKSSLSGQHGR--ERTQASAE
GCK------EG-----RERREKDRALGR-SSHRRRTG---------------------ES
RHKTRGDKIARKSSSRS-SFSHRANRD--------------------DKK--EKGCGNPG
-SSRHG-DSHKGVSHTPISKESRT-----SHKSGRSLSTTISG-----S-SK--------
-GLGRISSFLRNVRANLTTKAVG---------TPHGR---DVDIMAKMAE-RSTNVAIAE
TAEGGQGLE-MV-GSMTPDI-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------SSPG-----
ASTHARVPRAPA--------AWRLKLRLVTGRYYY-------LELDAP---DSEVGFLFD
RWIRLISRLQQPATSWAPR---TLHT----P--PT--GLS-----------------HL-
------------------------------------GPPAST-WRLQVPSRHR---HSVT
TAEPTFPYKI--LTAQRQKAKHT-------HRQTLKR-KFKSQAV-------------GD
SLPLVWSQLEHVDARKKSTEK--KPQPD-PSGRPK-TEIQVS------------------
------------------------------------------------------------
--------------------------------------------EKPSITIR---T----
--IFSIISN----TTDHME------S-------SPKAVVYPGL----LETPLHCISEHSP
ETPLLGTCDHLDMCAWQQHVD-----NLMDPETSTMSSCSICPADYTPNF-PSFN-----
----------------E------------KAR--------PL-----PP-TWKPLAVPTA
RHK------APFIL---DQ--SKRVSAM--------------------------------
----------P------APLQM-SAAPGPSQKATAYSPAPKKAPFQK-------PPHVPT
-IPRKASAVPGPSQKPRHAPAIPQKAPVMVAPSQRAPGTF--------GVSPK---AVSH
PAPNRKSVFLPAPSQKG-LTSPTQHRMTLGP--------DSVSMV----PSRSHGGDMLE
KRKPEEKPEPVK---L------------MGTKEKNVVDTRTQKTTVEVPFT--TTEKKSE
EVLIRRAQEITVNGLQGKGKLEDRVHTMK-EEIALDMPGFKSKEVGQQKKWVKTKKLAIQ
EAPQEQTRPFSVEGLTLAK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------VSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKVC-EEHVRQ-------GWF----AKGRGR--RPVKNLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LH-KT-CDVSAA
TSS-AY---------AGGEGIQHASHRTASAASLSRGTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGDIAVAGTATGPRTDVAIAGAATSP--ATGAMS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSV
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTASLSQDS-SLSAAFAGS
MT-TRKCAAERTE--GPAV------------GPLTSTLQSEGYMSERDG-SQKVSPPCAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKLSSHRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKIGSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKSNR--K-SPTRID--EKDDICVPD-SKDPGEL
QNMLNGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSPTI----KTPNV--------M
LLAHLTPTAQKD-----------SEPL---FKSLLTS-PSPENLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRIKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNKEKAKAS--KVSEVSS-LSEITNST--DITGSVDIMDIA-----AFPAIE
TSHLSTCSNPNNDVESIDFSEFTDITDV---TDVTDIPENEV-IE---APDIN-------
---------I-----V---------TEVTEVTD---I--------------CEVTASSGV
TVVFENDDILK--AKQEEKEKMENILKSGCLRDTK-SKNEFRE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-LTLTFEGERCFQTTLTPEEDETDKS---K----
--EMS-NRPSEIRTMDSESTTLKAEESRYVQQGDAK------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLSPEV-REPC--SGVEL-----GVENGLL
CQLIRSP-EFN-LFSN-----SMVFES------NFI--Q---------------------
-V------------TK-PGKWMNASEDSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGE-------------------CSTWNTP-GVGPVITL---SRILPL-----
RYVE-LQICDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFQ
FWIRLVKILRKGLSITTKD---PRIR----FTHCLVPKLTGLSTET--TP-ESSLPGSTQ
PSETL--LLLAAEQTSGSFSKLSG------------------------------------
--------------RTQF----------------------TADRSTK-------TAIKID
SSSS--------------------CNKTPSPVASP--VS----------VNIPMRATLSH
SLWEQDDPH-DHLL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MNGGRES-------KQAV------------
---------------RGQ--------------------NWP--LVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----LPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVRDVS--------RQQLKVKFHTGRAFY-------LQLRAP---ADTRDREFG
RWVR--------------------------LLYRL--RFH-----------------SPA
CAVPFTHEDA-------APE---EEEEE---E-------EE---------GSQ-------
--------------------D-----------LQLRPQEL--QSM---------------
------------EVKLDPQ---------------------------------------IS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGSRKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKTPDFQSTALEAEESRYVRQEHAKGIL---RHEILI------------
KKCVE-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKK-------NRKAVE--EQEPLWIPQ-SHGLGHL
KNILDGG-EYA-PFIS-----PPILES------NFI--Q---------------------
-VN------------R-KGESIYLHNRANWVTVGICSSNPIL----KTPNV--------M
LLAHLTPEARKE-----------SEPI---FKSLLAS-SSTENLVL---TRFLPL-----
QFVT-LSVHSAK--------NLRLKVKLISGRAYY-------LQLCAP---VYKQDIVFS
QWVDLITLLNREKTRTS--KVSEVSS-LSEITNST--DITGSMDIMDIT-----AFEELQ
AINPNTRIYSASIAESTELSEFTDVTDITDVTDVTDSPEYED-TD---VPDIK-------
---------I-----V---------TEVTELME----------------D-KEATNISGV
TVVFENDDIIK--AKREEKE---NILKHGCLRDMK-SKNEFRE-----------------
---------SP--------------------------------------------K----
--------------------RVTISN-LTLTFQGEKCFQTTLTPIKSEESIS---K----
--VMS-HESTKETMTDLPNYSLKATESRSVAWGNTVGIGG-CS-----------------
----L-RIQMCSSS-REKSF--------------------TYFLGSQPRG-FVFLYL---
----------ML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRPEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------GDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMCT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNFPCKKSLVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVGKKPAEK--KSHPDFHPDRTH-TQAH---F----------------
------------------------------------------------------------
-------------------------------------------SEKTSITIW---T----
--IFSIISS----TAKQTQSSPKACTTA-----SEEATGQGPV----VESPSYCVSADSP
DCFFLGSCSSLDPCLWHQDME-----DLMDSESSTLSSATSGLAPYPPAA-RLSTPY---
--------SSIPR-GRE------------KARSMGSHQGQGP-----PP-CQR---GPVT
SCK------APFLV---DQ--SQTLPAV--------------------------------
----------P------ASSWTPPPGLAPPQKVSAASAPP--------------------
-----------------------WKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKAPQTSPPQYQMAPGSPASRGRLPGD--VL----PTGIPGRAALE
RSPSGGKPEPAV---------------TVGTQETD-VVMTTQVKSLESPFT--VTKKESK
DILVSKTQEVTLEAFRGQGKLEDRAHLAKLEERSLDPPGARSKELEQRKRWVETKELAVE
GPSQELSRPFSVETLTLAKLTILANS---KEQ-RVKPS-LVSLPSWLLATSQASATSVMA
--SMPFHPGQLSSPEGKPVVVREQPESHTWVKEGKQQWGES--------KGSPWDPEGPP
PKVPLRSKPTSASPKREGISQAPIPLPASRWEGL--PPSP--LSETPISKTEATAKASQQ
PKRLSQEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVFNLPPR--------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGRGR--KPPKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPTDSCSSS---PTLH----TGNTSI-L-----EDNKSL-------L-V-
------------------------------------------------------------
---------RPEHSDI------------HGEGD---QDS-----V---RQ-KL-RDVSGA
TSA-AF---------AGGEGTQPATTAAAAAGV---------------------------
R---------GPAKGAAAGAVG-----------------GT-------------------
-------------VAAGVITG---------PSAGVAKAGTAASS--TSGALS-IAT----
-TR-SPGSS-QVAT-ALAGT-------------------------GSK-DSGGSGSSKAL
AAV-------ANI-SSEGTDLVLAGAASSSSESTS----AGGATSVTPEG-SLSVVFAGT
MT-TKGPAADR--PE----------------APLLSTLQSEGYMCERDG-SQKVPHIGSE
PRK------EKRER--RENKDRNP--SRKSTGKDKT------------------------
------KT-TRKSSSHRSISSPGKKRE--------------------SKK--GKAHSNLK
-GKRHGS-THKS--------ESRT-----AHKPRKSQSTTSSG-----SGSK--------
-KSSKISSFLKSFLIRPTSKTAV---------SSRNR--GGVDIVSKKVE-KHNVEAKME
KG---KEVE-YS-STVTAET-------------MERIIFEAKCV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNKIRGLPPEV-REPE--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------NFI--Q---------------------
-TCVPGAD---FQITE-PGNNMEVYDRSTTMILGVTSSVPSLPL----PNI--------L
LMATVTWPQGQ-------------------FSTQRTP-GDAPVITL---RRILPL-----
KYVE-LRICDRL--------QRILRVRTVTEKIYY-------LRLHRN-----HPEAVFQ
FWIRLVKILKKGLSITTKD---PRIR----FTHCLVPKMSSSSTES--TP-ENSLPSSSQ
PSETL--MLLAAEQTTDHFSQLSG------------------------------------
--------------RAHL----------------------TEDRSID-------PPVQKD
KSH----------------------KKISSPVASS--CN----------LKIPMRATLGH
SLWEQEDSN-EHFL-----------------NVPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSVPHRKT--WKSK---KTVKV
TKSYPTFP-------------SLNAWEEFRGL-LPADAEPN--SGVGL-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWINIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVRWHQGQ-------------------SQTWNRP-ATAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QRILRLRTVTEKIYY-------LKLHPD-----HPQTVFR
FWIRLVQILKEGLSITTKD---PRIL----VTHCLVPKNNSTPSED-SKV-KPLPEGT--
------------------------------------------------------------
-------------------------------------GCKQ--EAEACS-----------
QRQA--------------------PKAPSRKDDIP--CT----------HDFSWRESLTY
GEWERENPS-GPQP--------------LSLLSTLAASTRPR------------------
----------------------------LVPLIGTLR-GLIGLP----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------MEPPPPGTSSQ----------T-GSPLLCDVIKPDP
---------PAPHFLPRLLPPLPS-GGDIAMRRDRGA-------KPAV------------
---------------GGAGEVEPGGMA------------------A-SS----TGHPRRL
QRYLQSG-EFD-QLRD-----FPIFES------NFV--QFCPHIYP--------------
-VT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------R----LQL---FGLFPL-----
KFVQ-LFVHDES--------RCQLEVKLNTSRTFY-------LRLRAP---LETRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
SAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSESLLPY-YTANNY--QSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAKVC-EEHARQ-------VWS----AKGRGR--RPAKMLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFS
YWEKLVYLLRPPVENYSST---PTLQ----TRGMTS-------EDDRSL-------V---
------------------------------------------------------------
------------AGEL------------QGEGD---RNET----G---VH-KL-CEVSAA
SSS-AY---------AGGEGIQRG---MPSAASVATNPSGTTAGA-A-------------
------------------------------------------------------------
---------------TGAAGGLAVAGTGTGPRGGMALAGAATRP--ATGAMS-IAA----
-TK-PAGSG-EGTA-TLVGA-------------------------ATK-SAEAGGSSKAV
AGA-------TNI-SSGSMDVVLVGAASASSAGTS--TTTAGTASLTQDS-SLSVAFAGS
MA-TGKPGAERTE--GPAL------------GPLVSTLQSEGYMSERDG-SQKVSRSSAD
ARK------EKKEK--KGKKDRNH--SRKSSRHHRTG---------------------ES
HHRLGGDK-TRKTSSHRSVSGHKHKRD--------------------DKK--EKGQPSAR
-GKEHG-SSRKSSSHSATKKESRM-----THKLGKSRSAASSG-----TLSK--------
-KASKISSFFRSFRATPSSKTRV---------ASHDR---EVDIMAKSVE-KRNIEAKVE
KTPAGQELELIS-GTVTSET-------------TEMIIIETKAV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MGSNTALSH-CSTQSR--HMLHMFN----NSLGKL
QRQLDKG-EYD-IFKH-----IPMFES------DFI--Q---------------------
-IS------------K-RGEVLDVHNSVQMVTVGIAYTDPNLAI----PDI--------M
LLARPALSC-AANARH-------DKD----TQGRGL--KSIKSLEL---TRLLPL-----
KFVK-LSIYNHE--------KKQLHLKLTTGRSFY-------LQLCTL---SDSKEDLFS
YWEDLVYLLRPPVEAYSGT---QAEP----VGDMM--DIPVLEAEDKKS-------PAHI
------------------------------------------------------------
------------LILQ------------NIP-----------NTY---FP-YT-ISSVEH
F-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MMTSVPPRTS-WWNSK---KTVKV
IRSYTTFP-------------SLNAWGKFRGL-LPVDREPN--PGVGL-----GVEEGLL
CQMVHSP-EFN-LFPN-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWKKIYRASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWLQGQ-------------------SQTWNRP-STAPSIIL---KSILPL-----
KFVE-LQICDHH--------ERILRLRTVTEKIYF-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PSIL----VTHCLVPKSLCSPCGK-SEL-VQKKPPSPQ
PSESL--MQLMAQGESEALSQIFA------------------------------------
--------------DLHQ------------------QKQYSARRSKKIQI--N-------
KTSS--------------------DKATPSEESVP--CT----------RDLSWRDAFTY
GEWERENPS-GPQP--------------LSLLGTLAASSRPR------------------
----------------------------LSLS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MHNNVQMVTVGIAYTTPSLTM----PDV--------M
LLAQPAVSC-AANARN-------SQD----TQIKDL--KSTKSLEL---TRLLPL-----
KFVK-LSIYNHE--------KKQFHLKLATGRSFY-------LQLYLP---SDAKEDLFA
CWEDLVYLLRPPLEAYSGT---QAQP----AGDMI--SLPVLEAEDRKS-------PAAM
------------------------------------------------------------
------------ELR--------------GQGD---QDQD-SIKS---LP-TV-TNVSGV
TSH-AY---------SGGEGIRQ--LASHTYSVCRN--TLSLLIP-SA------------
------------------------------------------------------------
----------------------GSSH---------RAAVAPQ--GSSEGNVS-KQDGDHR
VSQVRDEVL-RKSK-EKEST-------------------------PAK-RPSHPGG----
------------M-EEDE----------SSLKSH--------------------RTTQGG
KTEDESNLKGQGH--GSSF------------QELVSF----SFI--QKGS-RWVPRFPF-
------------------------------------------------------------
---LPAFYWL--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-VSSCSWRLIL-------------------GQ---GL-FTLPSSLP---TRILPL-----
KFVE-LLIYDKS--------QQILRLRTVTEKTYY-------LKLHSN-----YPDVVFW
LWTRLVKILQKGLSFTTKD---PNVN----IPYCLVPRILPNSSDP-KER-PESNSSSSS
DGHNQ--IITEEKGAADNLSQLSM------------------------------------
--------------RKRS-QS-----EVLFRTEWGTQSQVSSSSTSRESLPNNKTGFSGG
SRHF--------------------FSTQIQEQHSH--CVHELGLLPREETASQWTDTGSY
GLWERENPS-VPQP--------------LSLLSTLAASTRRF------------------
----------------------------WPLL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRLEPL--QGTPKW----VPVQGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVYVNHTTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWCLKLRLVSGRQYY-------LALDAP---DNEAAFLFP
RWIRLIHLLQEPPPAWAPR---TMHT----A--SL--DVP-----------------LA-
------------------------------------KVPAST-WHLQVGPQLH-RPGRVR
VAEHNSPYKKSAVATRRQRKAK-----------ALRR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHPDSRPDRTH-TQVH---F----------------
------------------------------------------------------------
-------------------------------------------SEKTSVTIW---T----
--IFSIISS----TASQAQSSPKACTSA-----SDEATGQGHL----VESPSYCVSADSP
DCFFLGSCSSLDPCLWHQDME-----DLMDSESSTLSSAASGLAPYPPAA-CLSTPC---
--------SSIPR-GRE------------KARPMGSHQGPGP-----PP-CQKAPAGPVT
SCK------APFLV---DQ--SQKLPAA--------------------------------
----------P------ASSWKPLPGLAPPQKVPAASAPPWKAPAVPAAS--QKA-----
----------------PAASAPPWKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALPTSPPQYQMALGSPASRGRLPGDFDVL----PAGIPGRAVLE
RSQSGGKTEPAV---M------------VGTQQTDVVEMTTQVKSLESPFT--MTKKESE
DILISKTQEVTLEAFRGQRKLEDPAHLAKLEERSLDLPGVRSKELEQRKRWVKAKELAVE
GPSRGHSRPFSVEALTLAKLTIMANS---KEQ-RVKPA-PVSLPSWLLATSQASATSVMA
--SMPFHPGQLSSPEGKPVVVREQPGSHTWVKEGERQWGES--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQAPIPLPASRWEGL--LPSP--LSETPISKTEATAKASQQ
PKRLSQVPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGAGL-----GVEEGLL
CQVVHSP-EFN-LFPD-----SVVFES------NFI--Q---------------------
-V------------KR-GRNWRDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVKWHQGQ-------------------NQTWNRP-SIAPNIFL---KRILPL-----
KFVE-LQVCDHY--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCSSPSGD-SKL-VQKKLQASQ
PSESL--IQLMTKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQL--RRSRKV-------ETNKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALAFS-LRA----
-G--S-DPG--VLR-----VIPESCGVWS--RNAGHRDLSP-LFPTGLSKTMMCGTSRAP
RVL--------------PDAVDTIAAFSCCMGGV------RDLLCRLPMWSFLSFPFLEL
L-----------K----------------------------GLLTAWVG-MQRVKRK---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNEAMLPY-YTAQGS--RAVSMFN----AAMGKL
QRQLYKG-EYS-VFRY-----APMFES------DFI--Q---------------------
-IN------------K-RGELIDVHNRVQVMTVGIASTSPSLPL----PDV--------M
LLARPADPR-EEYATS-------GPD----AQREGP--KPSKPLEL---TRLLPL-----
KFVK-ISIHNHH--------LQQLHLKLTTGCSFY-------IQLCPS---PDAR-DLFT
YWEKIVYLLRTPVDYSCTL---SKQP----GDTMDK-TVPVVETEDKNI-------A---
------------------------------------------------------------
-------------SSI------------LNKSS---HSQNEMLPF---FH-LYIAQ---Y
SSDLTV-----------G------SVTSTE------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRPVSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----NKGKGC--KSSKILEL---TRLLPL-----
KFVK-ISIHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPMTNCISN---STLP----TGDTST-D-------TKST-------V---
------------------------------------------------------------
------------VSEI------------RREGG---QDS-----Q---LQ-SS-PTVSEA
TSA-TF---------AGGEKTQPAAAVAVTPGSAKARVAGVAGAT-AG-TTEA--AAGT-
A---------G-------------------------------------------------
----AIAGTAAGTAGAARAAGGTMAAAVTAPSAGMTKAETATSS--TSGVIS-MAAT---
-TK-SPGSG-QVAA-AMVGS-------------------------AAK-DQEGSESSKAM
ALV-------ANI-TLESVDLALAGAANSLLEPPS----AGGDASGSLDT-GLNVAFAGS
IK-TKGPAEDK--PE----------------APLVSTLQSEGYMCERDG-SQKVSQTSSE
AKK------EKRER--RE-KDRAS--SRKSSHHRRTGTS---------------------
RHS-SKDK-GRKAPSYRSVAG--KTRE--------------------DIK--GKGHGSLR
-GKRRSS-SHKS--------ESRT-----GHKTRKNRSPAGMG-----SVSK--------
-RATKIKSFFRSFLIRPTTKAGD---------TSCDR--GGVDIVTKLVEKKQDIETMME
KS---KDLE-LK-DTVISET-------------MEKIILETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--RSMSVFR----TSMGDL
QQQLHKREEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
LLARPAKVY-EEHATQ-------DWF----AKGRRR--RPPKTLEL---TRLIPL-----
KFVK-ISIHNHE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLIYLLRPPVDSYSST---PTLL----TGDTAP-------EDNKNL-------L---
------------------------------------------------------------
------------AAEL------------HRKGD---QSET----G---LH-KS-CDVSAV
TSS-AY---------AGGEGIQHASHGMA------------AEGA-A-------------
------------------------------------------------------------
---------------ARTAGGM--AG-TTGPRAGVAIAGTAMSP--ATGAVS-IAA----
-SK-PAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDSMNLALVGVASTSLAGTSS-TTMAGAAHLSQDS-SLSMAFAGS
MT-TGKCVAERTQ--GPAL------------GPLVSTLQSEGYMSERNG-SQKLSQPSAE
AWN------EKKER--RKKKDKRP--SRKSSHHRKAG---------------------ES
HRRTAGDE-TQKASSHRSISGHKNTRD--------------------DKK--EQGRSKVR
-GKGRG-SSRKSSSHSSTKKESRT-----THKLGKNRSTSSTG-----ALSK--------
-KPSKIMSFLRSLRATAGSKTRV---------TSHDR---EVDIVAKMAE-KQNIEAKVE
KA---QELEVIS-GTVTSKM-------------MEMTIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-THVPEAD---FQVTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FTTWSTP-GDAPVINL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVSKMPTNSTET--TP-ENSLLSSPK
PSEPL--VLLVPEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSH
SLWEQEDQN-EHLL-----------------QVHIASYLG--------------------
----------------------------------EHFLGA--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------LCVGNIRSYFSF-RSFTAC--AASRNQI----SIMGDL
QRVLGKG-EYA-PFTS-----APIFES------NFV--Q---------------------
-VN------------R-RGEPIYVHNRPNCVTVGICASSPSLSL----PNV--------M
LLAHTVTKS-PQEVTS-------KPW----KVSKQP--PTMEQLEL---SRFFPL-----
KFVE-ISVHNAE--------KRRLKLKLASGRSFY-------LELCGP---PDEQHLLFR
QWLRLISLLKLPQDRYNNT-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------SGTSSQ----------T-RNPLLCDVIKPFP
HHDATVRVVPPPRFLPRLLRPLPS-GGDIAMRRDRGP-------KPAL------------
---------------GGAGEVEPGGMA------------------A-SP----KGRPRRL
QRYLQSG-EFD-QFRD-----FPIFES------NFV--QFCPDIYPAPTSILPLTSDLWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPAKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDKS--------RCQLKVKLNTSRTFY-------LQLRAP---LKTQDREFG
QWVR--------------------------LLYRL--HFL-----------------SA-
STVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EYN-LFPD-----SAVFES------NFT--Q---------------------
-LVSTA-PRSLLQVTK-PGNWMDVFEGSTTVVLGVTSSVPCLPL----PNV--------L
LMANITWPQGP-------------------FSTWSKP-GDAPVITL---RRILPL-----
KYVE-LQICDRL--------QRILRVRTVTEKIYY-------FKLHEK-----HPEAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKT---STDT--TP-ESSLSPSSQ
PSESL--LLLAAEQTNDNLLQFSE------------------------------------
--------------QPSV----------------------TTARHTK-------ITTEKD
NSN---------------------SNKTPSETASP--IS----------LNIPMRATLSH
SLWEQENSG-EPAI-----------------ETPVASALG--------------------
----------------------------------DNFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPHRKT-WNKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDGEPN--PGVGL-----GVEEGLL
SQMVHSP-EFN-LFPE-----SVVFES------NFV--Q---------------------
-V------------RK-GRNWIDIYKACNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHHEQ-------------------NQTWNKP-STAPKIIL---KRILPL-----
KFVE-LQVSDRL--------QRVLRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLIQILQKGLSITTKD---PRIL----VTHCLVPKSSCSPSGD-SQL-VQKKPQASQ
PSESL--MQLMAKGESEALCQIFA------------------------------------
--------------DLHQ------------------HHLFR--SSRK-------TENNKD
SS-G--------------------KKTSPSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQS--------------LSLLSTLAASTGPQ------------------
----------------------------LAPLIGSSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PLL----PLPDV--------M
LLARPATSCHDHVG--------RGQA----TKGRGR--KAPELGAH---QAPALD-----
-VVR-TSVHDRQ--------KQQLRLKFAPGRSCF-------LQLCPP---LHAGETSF-
HWEELIHLPRPPGDSRSST---HAVP----AGDMT--RAP-----------------GLE
EEA------------------------------------RPA-LPLQGQGGQD--QVSLR
SLLTASGCRGPPLRLCR-------------------------------------------
-----------------------GGGDQICPPKPT-T---KPDTA-K-----PTPP---A
TGAAA------------------------------GAVAGAAGAGAGAVRVAD--T----
--------------------E-------------------------HSTAVA---G----
--AATKGPG----DS---------------------------------------NSSLAV
AGV--ADVP------WKNIKVAVAGAASQAPERTAST---AGSTALS-RA-QLSVALAGA
AAATSLGQGPLRT-RR-------------W----GRPRTAEARKERRER-RERRDKDRAP
SRT---------------G--SR----RH-----SAG---------------------DS
RSN-------ARSSGRSLSSRRSP-RE--------------------ERK--ERGRGSPG
-CSRRSSAHEGVTARSPRAPD--------GSRSGRSPSRVRAS-----CTCK--------
-RLGRSSSSLRRGKAPL-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLTSIPHRKT--WKSK---KTVKA
TKSYPTFP-------------SLNAWEEFRGL-LPVDAEPN--SGVGL-----GVEKGLL
CQMVHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------KR-GRNWIKIYKASNTMALGVTSSVPCLPL----PNI--------L
LMARVRWHQGQ-------------------SQTWKRP-AIAPNIIL---KRILPL-----
KFVE-LQVCDHL--------QRILRLRTVTEKIYF-------LKLHPD-----HPQTVFH
FWIRLVQILKEGLSITTKD---PRIL----VTHCLVPKNNCSLSED-SK----KKLQASQ
RSESL--MQLMAKGESEALSQIFD------------------------------------
--------------DLHQ------------------QKRFRSNKKMKMN-----------
KACS--------------------D--PPWRDDVP--CT----------HDFSWRESLAY
GEWERENPS-VPQP--------------LSLLSTLAASTRPR------------------
----------------------------LALPVGMSR-GSIQLP-GDSLEFH-LRA----
-S--P-AWR--S------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MET-------ESFRIR--LESMSV----DPRGGHL
QKYLYNG-EYD-HFRH-----IPIFES------DFI--Q---------------------
-VS------------K-KGGILDIHKKVTLVTIGVMATSPAL----MLPNI--------M
LLAKHVWQATLEHCACMPGCRLCGGTA---PRTRSK--EHGVQMEL---TRLFPL-----
KFVK-LTIHDSN--------KYQIKMRLANGCRYY-------LQLYAP---SDREKVLFE
KWKFLISILLPHPQGQGRG---YSSS----W-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKSNR--K-STTRIN--EQDAIYVPR-SQDPGGL
QNMLDEG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNQANWVTVAICSSSPSH----GTPNV--------M
LLAHPTPAARKD-----------TEPL---FQSLLTS-PSPEKLVL---TRFLPL-----
QFVT-VSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---AHEQDTLFC
QWVELISLLNQEKAKAS--KMSEFSS-FSEITNST--EITSSLDIMDIA-----AFTAVQ
PQHMYTYIDTVHAIESIDFSEFTDNTDV---TDITDIPENEV-TE---VPDVK-------
---------I-----V---------TE---VRD---L--------------CDVTNHAEV
TEVVEGDDILR--AKQEEEEKLENILKPECPQDSK-TKNELKE-----------------
---------SS--------------------------------------------N----
--------------------SVTISN-ITLNFEGEKCFHTTVTPEENETNTS---K----
--EMS-DKTSEIRTTDFNNVALKAADSRYVR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRPEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------GDCSGLVL---TRMIPL-----
DLIH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMCT----A--PL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNFPYKKSPVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVGKKP------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------ACTSA-----SEEATGQRPV----FESPSYCVSADSP
DCFFLGSGSSLDPCLWHQDME-----DLMDSESSTLSSAASGLAPYPPAA-RLSTPY---
--------SSIPR-GRE------------KARSMGSHQGRGP-----PP-CQT---GPVT
SCK------APFLV---DQ--SQMLPAV--------------------------------
----------P------ASSQKPPPGLAPPQKVSAASAPP--------------------
-----------------------WKASAVPAPPQKAPPPSQKA-PSVPTIPQK---AVCP
TAPKRKSLLLPAPSQKALQTSPPQYQMAPGSPASRGRLPGD--VL----PTGIPGRAALE
RSPSGGKPEPAV---------------TVGTQETD-VVMTTQVKSLESPFT--VTKKESK
DILVSKTQEVTLEAFRGQGKLEDRAHLAKLEERSLDPPGARSKELEQRKRWVETKELAVE
GPSQELSRPFSVETLTLAKLTILANS---KEQ-RVKPS-LVSLPSWLLATSQASATSMMA
--SMPFHPGQLSSPEGKPVVVREQPESHTWVKEGKRQWGES--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQAPIPLPASRWEGL--LPSP--LSETPISKTEATAKASQQ
PKRLSEEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVFNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTANSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHVRY-------TRP----TKGRGR--KPAKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVESCSST---PTLQ----TGDVTT-E-----D-DKSL-------L---
------------------------------------------------------------
------------LVST------------YRDPS---KQGM----G---LW-ET-------
GSG-AY---------VGGEGIQHVPQGSDLAKK---SAEGAAAAG-TT-EGL--------
------------------------------------------------------------
--------------------GLAVAGSRMSTGGGVAVAGVGTGS--TTGAVS-LAA----
-TK-STGTS-QVSM-ALAGA-------------------------TTK-SSGESRASKAI
AGA-------ANI-SSEGTNLALVGAASTSSMGGD-----------SPES-STSLVFAGT
VT-TGSPA----------A------------PPLVSTLQSEGYMCERDG-SQKVSHPSTG
ARK------EKKER--RERKDKSS--SRKSSRHRRTG---------------------ES
HHRTGGDK-TRKSSSHRSLSDHGNR-D--------------------DKK--EKGQSGTR
-GRGR--GSHKGGSRSSTTKEGRA-----THKLGKSRSTTSSG-----TLSK--------
-KSSKITSFFRSIRVIPGSKTAV----------THDR---EVDFVAQAVE-KRNLEARVE
KAPVGQDLE-IC-GTMRSET-------------METIIIETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGFPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSD-----SVVFES------NFI--Q---------------------
-V------------IK-PGNWKDVCERSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWNTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------RRILRVRTVTEKIYY-------LRLHEK-----HPETVFQ
FWIRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSTET--TP-ENSLLSTPQ
PSETL--MLLAAEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNDD-------TAIETG
NYRS--------------------C-KIPSPVASP--IN----------LNIPMRAALSH
SLWE--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MMRGHEI-------KPAP------------
---------------SGT--------------------ECP--LVPGYP----TGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPAKDNG----------------------------R----LQL---FGLFPL-----
QFVQ-LFVHNES--------RWQLKVKFRTGRAFY-------LQLRAP---AESRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAE
GAVPFTQEYS-------PVE---DGDD-------EDDEDDDL-IEREEVGGGA-------
--------------------G-----------ML-GRSQI--QAM---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGRGR--KPSKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPTDSCSS----PTLP----NGDIAT-P-----EEAKSL-------L---
------------------------------------------------------------
------------GSEI------------HGEGD---QDS-----G---RQ-KL-RDVSGA
TSA-AF---------AGGEGTQPATTAS--------------------------------
-------------AGVAAGAAG-----------------GT-------------------
-------------VATGVTTG---------PSAGVARVGPATGS--PSGAVS-MAA----
-AK-SPGSG-QIIT-ALAGT-------------------------ASK-ESGVSGSSKSL
AAV-------ANI-SSEVIEVVLAGAASSSSESTS----AGGAVGATPDS-SLSVAFAGA
LT-TKGPAADK--PE----------------APLVSTLQSEGYMCERDG-SQKVSHTSSD
TRK------EKRER--REKKDRNS--SRKSSHHRRTGAS---------------------
HRSSGKDK-SRKSSSHRSVSGHGKTRE--------------------DKK--GKRHSSSR
-SKRHGS-SHKS--------ESRT-----AHKSRKSRSAASSG-----SVSK--------
-KSSKIGSFLRSFIIKPTSKPRV---------TSRDR--GGVDIVTKTVE-KHNIETKME
KG---NELE-FS-GTVT-ET-------------TERIIFEAKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------IFV--Q---------------------
-V------------TK-PGNWMDDCEGPTTVILGVTSSVPSLPL----PNI--------L
LMANVTWPQGQ-------------------FSTWSTP-GSAPVITL---SRILPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LRLHEK-----HPETVFR
FWIRLVNILQRGLSITTKD---PRIR----ISHCLVPKLPCRSAE---TS-ESSLPSSSQ
PSESS--MLLAAEQNSDRFLKLSG------------------------------------
--------------TSQL----------------------TVPRNTS-------SATEIE
NFNF--------------------DDNTSLPASSL--VI----------SNIPMRATLSH
SLWEQENAD-EYNT-----------------QAPVASSLG--------------------
----------------------------------ENFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MDRKSESLLPY-YTAQNG--SGVGMFN----TTMGKL
QRQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAP-C-EDVSGR-------GLSS-N--K---G--KKRKTLEL---TRLLPL-----
KFVK-ISIHKRD--------KQQLRLKFATGRSCY-------LQLCPP---PESKDDLFY
YWEKLIYLLRPPVDSNSST---YAIP----AGDMM--SMPLLDEEHKIT-------QKAD
------------------------------------------------------------
---------------T------------QGKKE---PDQV-SVKS---LT-V-ATEMSEI
SSS-AF---------AGGEGIHHDSHIATVVSRVPTPKMNSKVLS-RE-SV---------
------------------------------------------------------------
-------------------------------------TGAIV--GDLVGTFS-LPAN---
--R-SIGSG-HKNK-PTAGE-------------------------TVM-GARGSKSYLTI
TSA-------GKM-SPKSMKMALSGVASKSLEYI---P--NSSSSLSRKE-IMTITNSRI
ET-TGKPAGETAN--EPVP------------VILSLTVPSESHSSEDSS-HRKAYTA--K
VRK------ERRTR--RDQRAKERVSSR-GEHHHRTG---------------------ES
R-KTAGDKEFRKSVGHR-GGS-----N--------------------DKK--------DK
-GSKRS-RSHKGVSHIPITKESRS-----SHKLGRTLSTASSV-----STNK--------
-RMGRISLFLRNIRANLAAKGLA---------PQRGQ---DIDIISKTLE-KTDVNAVME
T-EDGQGLE-II-DSVTSEV-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLQPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FTTWSTP-GDAPVINL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVSKMPTNSTET--TP-ENSLLSSPQ
PSEPL--VLLAPEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSH
SLWEQEDQN-EHLL-----------------QVHIASYLG--------------------
----------------------------------EHFLGA--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------NEETMSSECMLPY-YTAHSS--RSTGVFS----TSRGDL
QQQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVTDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPVKAC-EEHSVP-------DRI----IKRRGR--KATKNLEL---TRLLPL-----
KFVK-ISVHNQD--------KQQLRVKFATGRTFY-------LQLCPS---SDAREDLFS
YWEKLIYLLRPPVESYSSI---PTLD----TGDATI-TSGCLTEDDRSL-------L---
------------------------------------------------------------
------------SAVT------------HGEGN---QNEV----R---LH-KL-HELSGA
TSA-AY---------AGGEGIQHAFHSSGTAAAGLTTTGSAAGTA---------------
-----------------------------------AAGA---------------------
---------------TGPTAGTAVTAARMASTTKFAVAGTATSP--AVGSMS-MAA----
-TK-STGPR-QANA-TLAGA-------------------------AAK-GPRESGSIKAM
A---------AGM-SSEGANVVLVRAASTTSVATSN-TSAAAT---TQ-GSSVSVVMAGT
TR-KS-------AV-GSVE------------RPLVSTLQSEGYMSERDG-SQRASHPRAE
TQE------K-KER--RE-KDRHV--SKNSSRHHRTG---------------------ES
RRKTGGHKSSRKSSSHRSVASHEAMKD--------------------DEK--EKGHSRRR
-RKGHSSSSHKSVSHSPSRKESRT-----APKLGKSLSTISSA-----SVSK--------
-KSSRISTFLRSFKIGS---------------KAQDK---EMDIVAKTVE-RCNIETTVE
KAEQGQEL--IS-GTLTSET-------------METIIFEAKPV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MK--KN--R-NKKAMN--KQEALFIPH-YYRLGHL
KNILDGG-EYA-PYVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPIF----KTPNM--------M
LLAHLTPEARKE-----------PEPL---FKTLLKS-SSSGTLVL---TRFIPL-----
QFVT-LSVHSAK--------NMRLKVKLINGRSYY-------LQLCAP---VYKQDIIFS
QWVDLIPLLNQEKIKNT--KVSEVSS-LSELTNST--DIAGSMDITDIT-----AFRELR
PRHPKTHRYPCNIMESADFSEYTDVTDVTDVTDVTDMLDNGI-TD---VQDIK-------
---------I-----V---------TEVTEVTEVTEVTEV----SEVSDV-KMATNISGV
KIVFENDDIIK--TKQEEKE---YTLKHRSLQDTK-TKSDYQD-----------------
---------SP--------------------------------------------N----
--------------------PVTMSN-IALALQDEGCFQTTQTPVKSKEDIY---K----
--EIC-DETSEENMIRLQNIHLKATESRSTRTDSDISD-GELK-----------------
----LGRYLHKQCSSREQSF--------------------IHSLGSLPRG-FVFLHL---
----------LL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTVSNESCLPY-YTARSY--YSMSEFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKNLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------L---
------------------------------------------------------------
------------AAEL------------PREED---QSET----G---LH-KT-CDVSAA
TSS-VY---------AGGEGIQHASHRMASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAMS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSV
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTASLSQDS-SLSAAFAGS
MT-TRKCAAERTE--GPAV------------GPLISTLQTEGYMSERDG-SQKVSPPSAE
AWN------EKKAR--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKLSSRSSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHG-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVMDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGSTS--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHRKT-WRKSK---RTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVAL-----GVEEGLL
CQMLHSP-EFN-LFPD-----SAVFES------NFV--Q---------------------
-V------------KG-GRNWREIHTASNTTALGVTSSVPCLPL----PNI--------L
LMANVKWHQGQ-------------------SQTWNRP-STVPNIFL---KRILPL-----
KFVE-LQVCDRH--------QRILRLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLIQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKV-EQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QKHLSFRSSKKV-------ETNKN
SSEK--------------------DSSG--EDSIP--CI----------RDLRWRASFTC
GEWERENPS-GLQP--------------LSLLSTLAASSGPQ------------------
----------------------------RAPPIGNSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
------AD---FQVTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSIET--TP-ENSLLSSPQ
PSESL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KLQL----------------------TADRNND-------TAIEID
NRSS--------------------Y-KIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KAAR------------
---------------GGA--------------------DRP--LAPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRSP---PETRDCEFG
RWVR--------------------------LLYRL--RFH-----------------SPT
CAVPFTHEDT-------APE---EEEEE---EEEEE---EE---------EVK-------
--------------------E-----------GQLQPPEF--QAT---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------VNSQFLLLNCTPHSS--STMSMFN----TAMGKL
QQQLYKG-EYT-MFSY-----TPMFES------DFI--Q---------------------
-IN------------K-RGEMIDVHNRAQTLTLGVVRTSPCLAL----PDV--------M
LLARPAPID--EHAG----------G----KQERVI--KPAQALEL---TRLLPL-----
KFVK-ITIHNSN--------KKQLRLKLATGHSFY-------LQLSPP---ADTTEDLFA
HWENLVHILRPAVDAHSHT---QEDT----ADNTL--TVPEPKEEDTSP-------E---
-A----------------------------------------------------------
------------HAMK------------F-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSMDVMDIT-----AFTAIL
TPYMYAGRGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDN-SDTTNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKIPDFQSTALEAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNNR--N-STTRIN--KQDAISVPP-FQDAGDL
QNMLDGG-EYA-PFVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KTPNV--------M
LLAHLTPEAQKD-----------TEPL---FQRLLTS-PSPENLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---ACKQDTLFC
QWVELISLLNQEKAKVS--KLSEVSS-LSEITNST--DITGSVDIMDIA-----AFAAIQ
TPHMYTCSDPVNAIESIDFSEFTDVTDV---TDVTDVPENEV-TE---APDIK-------
---------I-----V---------TEVTEVMD---V--------------CDVPNNSEV
TVVFENDDILR--AKQEEKEKMENILKPGCLRDTK-IKNECKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-VTLTFEGERCFHSTLTPEESDINSF---K----
--RMSIIRTSEIRTTDFSNTALKAEESRSMRTDSGTSDK---------------------
-YKLLN------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFTSVPPRKT-WRKSK----TVKV
TRSYSTFS-------------SLNAWGEFRGLFLPVDGEPN--PGVGL-----GVEEGLL
CQMIHSP-EFN-LFPQ-----SVVFES------NFV--Q---------------------
-V------------KR-RRNWIKIYKSCNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHHGQ-------------------NQTWNRP-PTAPKINL---KRILPL-----
KFVE-LRVCDRF--------QRILRLRTVTEKIYY-------LKLHPD-----HPDTVFR
FWIRLVQILRKGLSITTKD---PSIL----VTHCLVPKNCCSPSRD-SKL-VRKKPKASQ
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------LNQYSSKKM----------EIN--
KSSS--------------------ESDNPCEDCIP--CT----------RDLSWRDSFTF
GEWERENPS-GLQP--------------LSLLSTLAACTGPQ------------------
----------------------------LAPLIGKAT-GLMWAPPWDNLRAR-IRS----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKNQSKLPH-YTAQSS--PAMGMFN----TSMGKL
QQQLYKG-EYT-IFKY-----APMFES------DFI--Q---------------------
-VS------------K-KGEVIDVHNRARMVTVGIVRTSPHFTL----PDV--------M
LLARPAAIC-DDYNRH-------GPA----TQEKGY--KPTQILEL---TRLFPL-----
KFVT-ISIHNGK--------KQQLRLKLATGRSFY-------LQLCPP---SNT-KDLFV
YWENLVYTLRPPVEAYSGS---QATP----VGDTL--DITGFEEEDNSP-------EA--
------------------------------------------------------------
------------NAIH------------FYGRD---QDQV-DIRS---LH-MN-PELFGT
TSY-GY---------AGEE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSR-----------------
---------------------VKRTLSSECVLPY-YTARNY--RSMGVFN----TSMGDL
QRQLYKGGEYE-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVMDVHNRVRMVTVCIVSTSPVLPL----PDV--------M
LLARPAKVC-EQRTKH-------GLL----TKKRNQ--KPKRTLEL---TRLIPL-----
KFVK-ISIHNRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPPDSCSST---PTIR----TGDAAT-P-----DD-KSL-------L---
------------------------------------------------------------
------------ASDI------------CGEGD---QDS-----G---LL-KF-HEVRGA
SSS-AF---------AGGEGIQLATAAAAGS-----------------------------
------------------------------------------------------------
----------AKGGAAGTMGGGTAVGTSTSPTVGLAMAGAATGP--TGGAMS-VAA----
-AK-PAGSG-QDTM-ALAGA-------------------------ATK-ETAEGRASKAM
AAG-------TSV-SSDNINAVLAGAASTSSMGTS---T-AGATSVSRDN-SVSVVFAGA
MT-TKAPAEEKAK--GSVV------------APLVSTLQSEGYMCERDG-SQKVPKASAE
ARK------ERRER--REKKDRHA--SRKSSHHRRVGESH--------------------
RHRSGGDK-SRKSSSHQSVSSHRNKRD--------------------ERK--GKGSSKGR
-SKGHG-SPHKSRSHSSSNREPRA-----SHKVGKKRSTASSS-----SLTK--------
-KSSKISSFLRSFISSPSSKTAL---------ISRDQ---EVDIVTKTVE-RRNIETKME
KGQGGQEVE-IC-GTMTSET-------------METIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------MVPALFFPW-----CSSLRAHQRA-------GRCG------------
---------------DGRHGPKSALRAV-------REMGSS--GLAACA----LEGPGWL
QRHLLSG-EFD-QLRN-----FTVFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPTKENG----------------------------C----LQL---LGLFPL-----
QFVQ-LYIHDES--------RQQLKVKFCTGRAFY-------LQLQGP---AETRDLEFG
KWVR--------------------------LLYHL--HFQ-----------------AGQ
GAVPFTQ-EW-------GDE---DEE-----TGGDQEDREWD-WRDQL------------
--------------------------------------Q----DR---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTVSSEYLLPY-YTAHSY--RSMGVFN----TSMGEL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHARH-------ART----TKGRGG--KPMKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVDSCSST---PTLR----TGDEAT-L-----EDDKSL-------V---
------------------------------------------------------------
------------TPEL------------HGEGD---QDEF----R---LH-KP-HEVSRA
TSS-GY---------AGGEGIHHAHHRMPGSPAVLKTSGTTEGAA-SR-SAT--------
------------------------------------------------------------
--------------------GMAVAGTATSATTGLAVAGAGTRP--SSGAQS-ISA----
-TK-AIGPG-QVNTVALAGA-------------------------TAK-CLGESGSNKAI
AGV-------VNI-SSEGTNVA-LGAASTSSVGNS--TVTTGTDNLSSAS-SMSVVFAGA
VM-TGTPTGKD-----PVA------------APLVSTLQSEGYMCEQDG-SQKVSQPSAD
TRK------GKKER--REKKDRTS--SRKSSHHHRTG---------------------ES
HHRMGGNKSTQKSSSHRSLSSHDK-RD--------------------DKK--EKGQSHVR
-KRGH--HSHKSGS--SVAKESRT-----AHKSGKIKSANSSG-----TVSK--------
-KSSKIGSFFKSLKVISGSKAAA---------TTHNR---ELDFVAKTVE-KCNIEAKIE
KAQDGQ-ED-IC-STLTSET-------------METIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MIPL-----
DL-AHLYVHDLS--------AWRLKLRLVTGRYYY-------LELDAP---DSEVGFLFD
RWMRLISQLQQPATSWAPR---TLHT----P--PT--GLS-----------------HL-
------------------------------------GPPAST-WRLQVPSHRR---HSVT
TAEPTFPYKI--LTAQRQKAKHT-------HRQTLKR-KFKSQAV-------------GD
SLPLVWSQLQHVDARKKSTEK--KPQSDLPSGRLK-TEIQVS------------------
------------------------------------------------------------
--------------------------------------------EKPSITIR---T----
--IFSIISN----TPDHME------S-------SPKAVVYPGL----LETPLHCISEDSP
EMPLLGTCDDLDMCAWQQHVD-----NLMDPETSTMSSCSIHPAAYTPNF-PSFN-----
----------------K------------KAR--------PL-----PP-NWKPLAVPTA
PHK------APFIL---DQ--SKRVSAM--------------------------------
----------P------AALQM-STAPGPSQKATAYPPVPQKAPFQK-------PPHVPT
-VPQKAPAMPGPSQKPRHAPAIPQKPPVMAVPSQRAPGTL--------GVSPK---AVSH
PAPNRKSVFLPAPSQKG-LTSPTQHRMTLGP--------DSVSVV----PSRSHRGDVLE
KRKPEEKPEPVK---L------------MGTKEKNVVETRTQKTTVEVPFT--TTEKKSE
EVLIRRAQEIAVDGLKGKGKLEDRVHMMK-EEIDLDMPGFKSKEVGQQKKWVKTKKLAIQ
QAPQEQTRPFSVEGLTLAK-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LQNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGRVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEVGFLFH
CWVRLINLLQEPAPTWTPR---TTRT----A--PL--DMP-----------------LA-
------------------------------------EAPAST-WHLQDQPISR---HAVR
VAEHNFPHKT--VAAQRQRKAK-----------VLKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHSDPRPDRTH-TQIC---L----------------
------------------------------------------------------------
-------------------------------------------PEKTSITTW---T----
--IFSIISS----TANQTQSSPKACTSA-----SDEATGQGHV----VESPSPCVSADRP
DGFFLGSCSSLDPCLWHQDTE-----DLMDSEGSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KAGPMGSHQGPGP-----PP-CQKAPSGPVT
SCK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPS--Q-------
----KAPAIPASSRKPSAASASPRKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKKKSLLLPAPSQKALPTSPTQYQMALGPPPSRGKLPGNFDVL----PTGIPGRAVLE
RSQSGGKPEPAV---T------------VRTQETDVVEMTTQAKSPESPFT--VTKKESK
DILISQTEEVSLEAFRGQGKSEDRAHWAKLEERSPDPPGVRSKELEQRKRRVKAKELAVE
GPSQEHSRPFSVEALTLAKLMITANS---KEQ-RSKPA-LVSLPSWLLATPQVSATSMMA
--SMPSRPGQLSSLEGKPVVVREQPESHTWVKEGKRPWG--------EMKEPPWDPEGP-
PKVPFRSKPTSASLKREGISQAPIPLTASPWEDL--RPSP--LSETLISKMEATARVSQQ
PKRVSQEPV-----------------------------------------RMPAQHPLAT
VGSSSEILLPMLLEVETVRNTGTKAEETQEESGVLNLLPSLQHSQHSEWPDAGA------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPTI-RDPG--PGVEL-----GVVDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNI--------L
LMANVTWPHGP-------------------FSTCST--LGAPVITL---SRILPL-----
KYVE-LQIYDWT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQRGLSITTKD---PRIQ----FTHCLVPKITNSSTET--AT-ESSLPASSQ
NSEAI--MLLAAQRNSSSLLELSN------------------------------------
--------------RHQT----------------------SRDRHTD-------TATETD
NSG---------------------NCKTTPLVASS--------------ASMPMRAALTH
SLWEQEDSN-ENFL-----------------QAPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNADFLLPY-YTAQSG--SSMSMFN----TTMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GQA----TKRKKR--KAAKNLEL---TRLLPL-----
KFVR-ISVQDHE--------KQQLRLKFATGRSCY-------LQLCPA---LNTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WMPVFQEDRR-S-------L-G-
------------------------------------------------------------
------------ALNL------------QGKGD---QDHV-SIQS---LH-MV-SEVCGA
TSA-AY---------AGGEGLQNDFHKPTNVLNVSIPKTSTE-LA-EE-P-AT-------
------------------------------------------------------------
---------------G-AIKEAAAAG---------AAAGTAT--GTVAGALS-VAAA---
--N-SA-PG-QVST-AIAGA-------------------------ATI-GAGGNKSNMAL
AGT-------ASM-APNSTKVAVAGAAGKSSEHV---S--SASMSLSREG-SVSLAIAGV
VL-TSRTAAETDM--DAAA------------GPPVSTRQSKSSLSGQHGR--ERTQASAE
GCK------EG-----RERREKDRALGR-SSHRRRTG---------------------ES
RHKTRGDKIARKSSSRS-SFSHRANRD--------------------DKN--EKGCGNPG
-SSRHG-DSHKGVSHTPISKESRT-----SHKSGRSLSTTISG-----S-SK--------
-GLGRISSFLRNVRANLTTKAVG---------TPHGG---DVDIMAKMAE-RSTNVAIAE
TAEGGQGLE-MV-GSMTPDI-------------METVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNKR--N-SI---------------NEHDPGHL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYVHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLKPTAQKH-----------GESL---FKSLLTS-PSTEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCVP---ANKQDALFS
QWMDLICLLNQEKAKAS--KVSEVSS-LSEITNST--EVTSSMAIMDIT-----AFADIQ
TPHMYLCTEPVHVTESISLSEFTDVTDI---TDVTDIPENEV-TE---LPDVR-------
---------I-----V---------TEVTEVVEAIEATEV-------KNS-SDATNVSGV
TVVFENDDILR--AKQEEKV-Y-----------IR-SKCEFKQ-----------------
---------TS--------------------------------------------K----
--------------------HVTISN-LTLTFEGERCLQTTLTPIKSETNIS---K----
--EMS-DKTSEEKKTDFKDTALKTVESRYVT-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRNP-------KRAP------------
---------------GGP--------------------DRP--LVPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------C----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRAP---EETRDREFG
RWVR--------------------------LLYRL--RFH-----------------SPA
CPVPFTHEDT-------APE---EDEEE---EEVEEEEEEE---------EEG-------
--------------------E-----------EGQRPPEL--QAI---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNGDSLLPY-YTAQSG--SSMSMFN----TTMGRL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTMGIARTSPILPL----PDV--------M
LLARPATGC-EEYAGH-------GQA----TKRKKR--KAAKNLEL---TRLLPL-----
KFVR-ISVHDHE--------KQQLRLKFATGRSCY-------LQLCPA---LNTRDDLFA
YWEKLIYLLRPPMESNSST---CGIP----AEDMM--WMPVFQEDRR-S-------L-E-
------------------------------------------------------------
------------AVDL------------QGKGD---QDQV-SIRS---LH-MV-SEVCGA
TSA-AY---------AGGEGLQHDFHKPTNVLNVSIPKTSTE-LA-EE-P-AT-------
------------------------------------------------------------
---------------G-ATKEAAAAG---------AAAGAAT--GTVAGALS-VAAA---
--S-SA-PG-QVSV-AIAGV-------------------------ATI-GAGGSKSNMAI
AGT-------ASM-APNSTKVAVAGAAGKSSEHV---S--SRSMSLSREG-SMNLAIAGV
EL-TSRTAAETDM--DAAA------------GLPVSTRQSKSSLSGQHGR--ERTQASAE
ACK------EG-----RERREKDKALGR-SSRRRRTG---------------------ES
RHKTRGDKIAQKSSSRT-SFSHRASRD--------------------DKK--EKGCGSPG
-SSRHG-DSHKGVSHTPISKESRT-----SHKSGRSLSTTSSG-----S-SK--------
-RLGRISSFLRNVRANLTAKAVG---------TTYGR---DVDIMATTVE-RSTNVVIAE
TAEGGQGLE-MV-GSMTPDV-------------METMTFETH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------ATEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPQRKT-RWKSK---KTVKV
TRSFPTFP-------------PLNAWEEVRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQMLHSP-EFN-LFPD-----SVVFES------NFV--Q---------------------
-V------------RK-GRSWIDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------SQTWNRP-STAPNIKL---KRILPL-----
KFVE-LQVYDQL--------QRILRLRTVTEKIYY-------LRLHPD-----HPETVFH
FWIRLVQILHKGLSITTKD---PRIL----VTHCLVPKNSCSPSGD-SNL-VQKKPQASQ
PSESL--MQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------HDEFSSRSS----K--K-TQTKWD
-S-S--------------------EKDTPSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQP--------------LSLLSTLAASTRPQ------------------
----------------------------LTSHIGTVM-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLSPEF-REPC--SGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-V------------TK-PGKWVNVYEDSTTVTLGVTSSVPSLPL----PNV--------L
LMANVTWPQ---------------------LSTWNTP-GVAPVITL---SRILPL-----
RYVE-LQICDRP--------QRILRVRTVTEKIYY-------LRLHEK-----HPEAVFE
FWIRLVKILQKGLSITTKD---PRIC----FTHCLVPKLPRFSTET--TP-ESSLPGSSQ
PSETL--LLLAAEQTSGSFSELSQ------------------------------------
--------------RTQF----------------------TADRSTD-------TAIKIG
SSSS--------------------CNKIPSPVASP--IS----------VNIPMRATLSH
SLWEQDDPN-EHLL-----------------QAPAASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQNTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCSP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGNTS--DSSVFAEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPAI-RDPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATIILGVTSSVPSLPL----PNI--------L
LMANVTWPQGP-------------------FSTCST--LGAPVITL---SRILPL-----
KYVE-LQIYDRT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFR
FWIRLVKILQKGLSITTKD---PRIH----FTHCLVPKMPNSSTET--TP-ESSRPASSQ
SSETI--MLLAAERAGSSVLDLSN------------------------------------
--------------RHRF----------------------SEDRYTD-------T--KTD
NSS---------------------NCKTASPVASL--------------IGMPMRATLIH
SLWEQEDSC-ETLL-----------------QAPVASSLG--------------------
----------------------------------DNFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MKLDGESQ--KGQEL-----E------
------------------------------------------------------------
------------------RHLQSLLHYG--PGGDLLS---ALPA----PP----------
----QHPTHGQ-------------------CQ----------------------------
--MA-PGAEPDMEQTIHSPQHLPEELRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLRSSKKVEIN-----------
KNSS--------------------GRDSSREDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALVFS-LRA----
-G--S-DPG--VLR-----VIPESCVVWS--RDASHRDLSP-LFPTGLSKTLMCGTSRAP
RVP--------------PDAVDATAAFSCCVGGV------RGLLCRVPMWSFLSFPFLEL
L-----------K----------------------------SLLTAWVG-VQRVKRK---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKR--LFNL-RRTQPP--KDPQKW----VPILGEL
QKTLLKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-HGAPAFVHHRANRLTMGVAASLPGL----LLPDI--------L
LLAQPPE--S----------------------------RECSNMNL---TRMIPL-----
DFAH-LYVHDLP--------SWRLKLRLITGRYYY-------LELDAP---DDELSFLFD
RWIRLINLLHEPTISWAPR---TMDM----V--PL--DTP-----------------LG-
------------------------------------GAPAST-WSLTLLSLPL---SPVE
AAERTFPYKI--FSSQKQKKTK-----------AVKQ-RLKSQAV-------------GD
SIPLIWSHLQPAEPVELTEKK--SYLSDACPNESK-TLIHVS------------------
------------------------------------------------------------
--------------------------------------------EKASITIR---T----
--IFSIISG----TMNQEH-------SS-----TKVTSGRAHL----IETPTQCISHNSP
GLPIIDSRDHMEPFLWTKDLE-----DLIDTESTTTLSSSLQPSSYPPAF-YILPPS---
--------PSYHK-SSD------------KARHPGSTKHNRP-----LS-SQKAASAPVT
SGK------TPFIL---DK--SNKVPGE--------------------------------
----------P------APSQKAPSLPAPSQKAQK-------------------------
-----SSGKSNLSQKAPPTPGPSRKVPVPVSPPQKTLPPTP-------APSQKA------
MPPKKEHLAPNTQSQKS-D--RRQKQISQKSVDSRAKAPGDASK--------LPAGDML-
DRKPEGKQEPVL---L------------VAGQKSKVVDVRAQAMTLTLPTT--TTKKQSK
EILISKTQEITLETLKARGKVEDRGHKTK-EETTVNLPNLKSKEIGMQKKWVTTHEMAVE
APPTEDKRAFSVEGLALAKMMIMANS---TQD-HLKSA-TISLPSWFSLTSRGSAMSTLP
--DLPFQSSQMILPDGGQVEVREQSTSQIKEKENTQPQVEE--TPEDLYHPDGRI---FK
LACTQP------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MTTKPESLLPY-YTAQSG--SGVSMFN----TAMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPILPL----PDV--------M
LLARPAPGC-EDFPGR-------GQT----IKGKNR--KAAKALEL---TRLLPL-----
RFVR-LSVHNRE--------KQQLRLKFATGRSCY-------LQLCPP---LEGQDDLFT
YWEKLIYLLRPPVESNSST---YAIP----AEDMV--CIPLLDEEDKPN-------A-A-
------------------------------------------------------------
------------VAQC------------QGKGD---PDQV-SIRS---LP-MV-TDVTGV
SSA-AF---------AGGEGLHHNSRKPTTVQGVSIPETKSKDLA-KE-SATG-------
------------------------------------------------------------
------------------------------------AAAAAA--GGLAGALS-LAAT---
--R-SVDSG-QINA-AIAGG-------------------------AIM-GARGSQSHLSI
TSS-------GKM-SPESMKVALAGTASRSLEYI---S--SASTSISQKE-NMAMAIAGI
EP-TSKSVGETAS--DSDTA------------ALASTLPRESQKTEQTA-QPKAPEDNTE
ANK------ERRER--RERRAKDRAGS-RSSHHHRTG---------------------EG
HHKTAGDKGVRKSASSR-SAH--------------------------------T----LR
-GSKRN-RSHKGVSHVPITKESQS-----SHKSGRTLSSASSV-----STSK--------
-RLGRISLFLRNIRANLATKGLA---------SQREQ---DVNIVAKTLE-TTNVEAIME
T-ESGQALD-IT-GSVTSEV-------------METVIFEAS------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------PAL------------
---------------GRAGKAGPGGM-----------AG---------E----RGRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-SGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPSKENG----------------------------H----LQL---FGLFPL-----
QFVR-LSIHNES--------RRQLKVKFSTGRTFY-------LQLRPR---PETGDREFG
QWVR--------------------------LLYRL--RFH-----------------AAH
EAVPFTQAPE-------DD------------DD-C----------E--------------
-------------------------------------DEA--GDT---------------
------------EARLDPQ---------------------------------------TS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-PTMRIN--KQDALCTPH-SHDPGHL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEISS-LSGITNST--DITGSLDVMDIT-----AFTAIP
TPYVQAVTDPVHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVTEVRE---ATEV-------TDN-LDVTKCSGV
TVVFENDDLIR--AKQEEEEKIKDILKPGCLQDTK-SKSELKE-----------------
---------SP--------------------------------------------K----
--------------------HVTISN-ITVTFEGKGYFQTTLTPVESEANTS---K----
--EME-DKTSEEKTPDFKSTALKPEESRSLRTESNTSVL---SPHIKS------------
SSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKIC-EEHVRH-------AQT----TKGRGR--KPTKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVDSCSST---PTLH----TAEAVP-L-----EDDKGL-------M---
------------------------------------------------------------
------------TTEL------------HREGD---RDEF----R---LH-KPPREVSRA
TSS-GY---------AGGEGLHHAHSRMPGSPAVARAAGTAEGAA-AR-AVG--------
------------------------------------------------------------
--------------------SMA--GAATSTISGLAMAGAKTSS--SSGALS-LAA----
-TK-TSSTG-QVST-ALSGA-------------------------TSR-SPGESGSNKAI
AGA-------LSI-SSESTNVA-LGAASTSSADAS--VPTTGTASLSPGS-SLNVVFAGA
LT-TGAPAAEKAAA-CSAV------------GPLVSTLQSEGYMSERDG-SQKVSLPRAE
TRK------EKKER--REKKDRTS--GRKSSHHHRTR---------------------ES
HHRTGGDKSTRKSSSHRSLSGDDK-RE--------------------DKK--EKGKTHGR
-SKGH--SSHKGGGHSAGAKESRT-----AHKLGKIKSITSSG-----AVSK--------
-KSSKIGSFLKNLKVIPGSKTVV---------RSHDR---GLDFVAKTVE-KRNIEAKLE
KAPGSKDLE-IS-GTMTSET-------------METIVIEAKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPSAV-RDPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGNWMDAYERSATMILGVTSSVPSLPL----PNV--------L
LMANVTWPHGP-------------------FSTSST--PGAPVITL---SRILPL-----
KYVE-LQIYDRA--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKIPNSSTEI--TP-ESSLPSSSQ
ASETI--MLLAAERASDSLLGFSK------------------------------------
--------------RHQL----------------------TGDGHTD-------TTPVKD
KSN---------------------SCKTPPLMASS--------------TNMPMRATLTH
SLWEQEDPN-ENFL-----------------QVPVASSLG--------------------
----------------------------------ENLLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKRGHES-------RPAL------------
---------------GGAGEAAPGGM-----------ADRP--LVPAYP----TGRPGRL
QRHLQSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPTKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RCQLKVKFRTGRAFY-------LQLRAP---PETRDREFG
QWVR--------------------------LLYRL--RFH-----------------SAQ
GAVPFTQEDW-------ALE---GPDDD---AEDEEDEAEAQ-VEC--------------
-------------------------------------EQL--QAM---------------
------------EARLDPQ---------------------------------------MS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MKK-------NRKAVE--EQEPLWIPQ-SHGLGHL
KNILDGG-EYA-PFIS-----PPILES------NFI--Q---------------------
-VN------------R-KGESIYLHNRANWVTVGICSSNPIL----KTPNV--------M
LLAHLTPEARKE-----------SEPI---FKSLLAS-SSTENLVL---TRFLPL-----
QFVT-LSVHSAK--------NLRLKVKLISGRAYY-------LQLCAP---VYKQDIVFS
QWVDLITLLNREKTRTS--KVSEVSS-LSEITNST--DITGSMDIMDIT-----AFEELQ
AINPNTRIYSASIAESTELSEFTDVTDITDVTDVTDSPEYED-TD---VPDIK-------
---------I-----V---------TEVTELME----------------D-KEATNISGV
TVVFENDDIIK--AKREEKE---NILKHGCLRDMK-SKNEFRE-----------------
---------SP--------------------------------------------K----
--------------------RVTISN-LTLTFQGEKCFQTTLTPIKSEESIS---K----
--VMS-HESTKETMTDLPNYSLKATESRSVAWGNTVGIGG-CS-----------------
----L-RIQMCSSS-REKSF--------------------TYFLGSQPRG-FVFLYL---
----------ML------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGP-------------------FSTWSTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSIET--TP-ENSLLSSPQ
PSESL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KLQL----------------------TADRNND-------TAIEID
NRSS--------------------Y-KIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------M-EPPLLCDVIKPDP
HHD-------PPHFLPRLLPPLQA-GGDIAMRRDRGA-------KPAL------------
---------------GGAGKVEPGGMA------------------A-SP----TGRPRRL
QRYLQSG-EFD-QLRD-----FPIFES------NFV--S-------ARTSILPLTSDPWP
QVT------------R-LGE------VANEVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---FGLFPL-----
KFVQ-LFVHDES--------RCQLEVKLNTSRTFY-------LRLRAP---LETRDREFG
QWVR--------------------------LLYRL--RFL-----------------SA-
SAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRLEPL--QGTPKW----VPVQGEL
QKTLQKG-EYL-PLCP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMRT----A--SL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNSPYKKSLVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHPDSRPDRTH-TQVH---F----------------
------------------------------------------------------------
-------------------------------------------SENTSITIW---T----
--IFSIISS----TANQAQSSPKACTSA-----ADEATGQGHV----VESPSCCVSADSP
DCFFLGSCSSLDPCLWHQDME-----DLMDSESSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KARPMGSHEGPGP-----PP-CQKAPAAPVT
SCK------APFLV---DQ--SQKLPAA--------------------------------
----------P------ASSWKPPPGLAPPQKVPAASAPPRKAPAVPAAS--QKA-----
----------------PAASAPPWKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALPTSPPQYQMALGSPASWGRLPGDFGVL----PTGIPARAVLE
RSQSGGKPEPAV---T------------AGTQGTDVVEMTTQVKSLESPFT--MTKKESK
DILISKTQEVTLEAFRGQGKLEDPAHLAKLEERSLDLPGVRSKELEQQKRWVKTKELAVE
GPSQEHSRPFSVEALTPAKLTIMANS---KDQ-RVKPA-LVSLPSWLLATSQASATSMMA
--SMPFHPGQLSSPEGKPVVVREQPKSHTWVKEGKRQWCDS--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQPPIPLPASRWEA----------------------KASQQ
PKRLSQEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTAHSY--SSMSAFK----TSMGDL
QRQLYNRGEYD-VFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLAQPTKIC-EEHVRR-------GRF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLIYLLRPPVESYCST---PTLL----SGDAPS-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HREGD---QSET----G---LY-KP-CDVSAA
TSS-AY---------AGGEGIQHASHGTASVASPSTSTPGAAEGG-A-------------
------------------------------------------------------------
---------------ARTAGGMAVAGTATGPRTDVAIAGAATSP--ATGAMS-IAT----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSEGTS--TSMAGAASLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYVSERDG-SQKVSQPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAG---------------------ES
HRRRAGDK-NEKASSHRSASGHKNTRD--------------------DKK--VKGHSNVR
-GKRHG-SSRKSSNHSSTKKESRT-----TQELGKNPSASSTG-----ALHK--------
-KASKISSFLRRLRATPGSKTRV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTMTSEK-------------TEMIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MMKKTS--K-STTRIN--EQDALCTPH-SHDPRDL
QSMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGARKD-----------TEPL---FQSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDTE--------NMRLKVKLVSGRAYY-------LQLCTS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DVTGSTDVMDIT-----AFTAIL
TPYMYTRTGPEHVRDSIDFSEFTDITDI---TDVTDLPENEV-PE---VPDIR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-NKTSEEKTPDFQSMALKAEESRSLRTESNTSVL---SPHIKS------------
PSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEGQCMLPY-YTAESS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-TGEVIDVHNRARMVTVAIVRTSPCLTL----PDV--------M
LLARPAVVC--DNARC-------GPA----TQERGS--PPAQLLEL---TRLLPL-----
MFVK-ISIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGNTS--DSSMFEEMYRSP-------MA--
------------------------------------------------------------
------------YAMK------------FFEE----KEQI-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------MRPPLYPEVQEPP-----------------L-QRSLLCDVIKPTP
LRDVTVPVAPPPRFL----PPLLSRCGDFAMRRERGP-------KLAL------------
---------------GGAGEAELGAMA------------------A-SP----TGRPRGL
QRHLLSG-EFD-QLRD-----LPIFES------NFM--Q---------------------
-VT------------R-LGE------VANKVTMGVAASSPAL----ELPDL--------L
LLASPAKENG----------------------------H----LQL---FGLFPL-----
QFVQ-LFVHDES--------RWQLKVKLSNHRAFY-------LQLQAP---PETRDREFG
QWVR--------------------------LLYRL--RFQ-----------------SA-
PAVPFTQE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEEQCTLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQNTDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLIYILRPPVEAYSGT---KAIL----AGNTS--DSSVFGEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------LCKE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------QIRGLPPEV-REPC--SGVEL-----GVGDGLL
SQLIHFP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-V------------TN-PGKWMNLCEDSNTVIRGVTSSVPSLPL----PDI--------L
LMATVTWPQGQ-------------------LSTWNAP-ELAPVMTL---SSILPL-----
RYVE-LQIYNRP--------QRILRVRTVTEKIYF-------PKLHEK-----HPEAVFQ
FWIRLVRILQKGLSVTTKD---PRIR----FTHCLVNMTSLLT--A--TP-ESSLPGSSQ
PSETL--LLLAAEQTSSSFLELSG------------------------------------
--------------RTQL----------------------TANRSTD-------TAIKIK
CSSS---------------------HKTPLPVVSQ--VN----------VNTPLRATLSH
-----NDPN-EHLL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-THAPEAD---FQVTK-PGNWRDVCEGSATVILGVTSSVPSLPL----PNV--------L
LMANVTWPRGQ-------------------FSTWSTP-GDAPVITL---SRLLPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIE----FTHCLVPKMPTSSIET--TP-ENSLLSSPQ
PSESL--VLLAAEQTGGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NCSS--------------------Y-RIPSPVASP--IN----------LNIPMRAVLSH
SLWEQEDPD-EHLL-----------------QVPVASSLG--------------------
----------------------------------EHFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNTESLLPY-HTAQSG--SGVGMFN----TTMGKL
QRQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPAAGC-EEHGRG-------Q-----AAKGKGR--KAAKALEL---TRLLPL-----
KFVR-ISIHDRE--------KQQLRLKFATGRSCY-------LQLSPP---LHGREDLFA
HWEKLIYLLRPPVDSNSST---YAIP----AGDML--CMPEFEEEDGRS-------A-A-
------------------------------------------------------------
------------GADF------------QGKGD---QDQV-SIRS---LH-VV-SEVAGA
TSA-AF---------AGGEGPPRDAHKPSRSTHAAELALGSAAGA------TA-------
------------------------------------------------------------
---------------A-AAAAGTAAG---------FAAAIAA--GTAAGALG-VAIT---
--K-PG------------------------------------------------------
-GA-------PSA-SPKSAAAAVAGAAKTPGFPS---D---SSTSLSPEP-SKALAFAGA
AG-------------EAAQDAAAARL---------TQARRAGGAAEPA----------GR
GRG------RRRER--RERREKERARR--GSRRRRPA---------------------DS
RHKASGDKGPRKASSRA-SAGRRAARE--------------------DQ---ERGRRSPG
-DARR---AQPSGGHAPAATESRT-----SHRSGRSASTASSG-----SARK--------
-RLSRIGVFLRNVRANLATRTVA---------SARRR---GVDALAKTAE-GGGMEAILE
AAESGQLAG-A--GSGTH-G------------ILETVTFGAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MKGGRDL-------KAAP------------
---------------GGA--------------------DRP--LAPAYA----PCRPGRL
QRHLLSG-EFD-QLRD-----FPIFES------NFV--Q---------------------
-VT------------R-FGE------VANKVTMGVAASSPAL----ELPDL--------L
LLAGPDKENG----------------------------H----LQL---LGLFPL-----
QFVQ-LFVHDES--------RQQLKVKFRTGRAFY-------LQLRSP---PETRDCEFG
RWVR--------------------------LLYRL--RFH-----------------SPT
CAVPFTHEDT-------VPE---EDE---------D---ED---------EVE-------
--------------------E-----------GQLQPPEF--QAT---------------
------------EARLDPQ---------------------------------------VS
ELWGL-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNPR--R-STTKIN--EHGALRNSC-SGGPGEL
QNMLNGG-EYA-LSLF-----PPMLES------NFI--Q---------------------
-VN------------R-KGESIYIHNRANWVTVGVCSSSPNN----KIPNV--------M
LLAHLTPTTQRD-----------KKSL---FKSLLSS-P-RQKLVL---TRFLPL-----
QFVN-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAP---AQKQETLFC
QWVELIALLNQEKIKTT--KVSEVSS-LSEITNST--DITGSGDIMDST-----VFAALQ
SQQMHECIEPTHVMGSTDFSEYTDVTDI---TDVTDVPENEV-LE---VPEVR-------
---------I-----V---------TEVTEVTD----------------I-PDVPKYDSV
KMVFENDDIKR--AKQQVKEKLENVLKTGCLRNSKRDKNDLKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISN-VKLTCEDQRCFRTTLTPKVSETNLS---K----
--ETD-DKTSEERKTDVEDTAVKPEESRYFRSSENAQFL---SLHIKS------------
SSTFLNFVPHLPPL-FSEG-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RCLEPL--QGTPKW----VPVLGEL
QKTLQKG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RNCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEVGFLFH
CWVRLINLLQEPAPTCTPR---ATRT----A--PL--DMP-----------------LA-
------------------------------------EAPAST-WHLQDQPISR---HAVR
VAEHNFPRKT--VAAQRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHSDPRPDRTH-TQIR---L----------------
------------------------------------------------------------
-------------------------------------------PEKTSITTW---T----
--IFSIISS----TANQTQSSPKACTSA-----CDEATGQGHV----VESPSHCVSADRP
DGFFLGSCSSLDPCLWHQDTE-----DLMDSEGSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KAGPMGSHQGPGP-----PP-CQKAPSGPVT
SCK------APFLV---DQ--SQKLPAV--------------------------------
----------P------ASSWKPPPGLAPPQKAPAASAPPRKAPAVPAPS--Q-------
----KAPAIPAPTWKASAASASPRKASALPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKKKSLLLPAPSQKALPTSPTQYQMALGPPASRGKLPGDFDVL----PTGIPGRAVLE
RSQSGGKPEPAV---T------------VRTQETDVVEMTTQAKSPESPFT--VTQKESK
DILISQTEEVTPEAFRGQGKLEDRAHWVKLEERSQDLPGVRSKELEQRKRWVKAKELAVE
GPSQEHSRPFSVEALTLAKLMITANS---KEQ-RSKPA-VVSLPSWLLATPQASATSMMA
--SVPSRPGQLSSLEGKPVVVREQPESHTWVKEGKRPWGEMKERPWGEMKEPPWDPEGP-
PKVPFRSKPTSASLKREGISQAPIPLTASPWEDL--RPLP--LSETPISKMEATARASQQ
PKRVSQEPV-----------------------------------------RMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLLPSLQHSQHSEWPDAGA------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------MLRR--LWNF-IFPP-P--PEPPKW----VPILGEM
QKTLEMA-EYL-PLRP----L-PMFES------NFT--Q---------------------
-VN------------N-NGTPALLHNKPNKLTMGVAASLPGL----VLPDI--------L
LIARPPD--G----------------------------QECSSLIL---TRMIPL-----
DLAR-LYVHDLT--------TWRLKLRLRSGRHYF-------LALDAP---EHELAFLFD
RWIRLINMLREPKLSRGPK---SVAV----DPSHR--ETA-----------------PE-
------------------------------------GTPAST-WHFQTQSQGE---LTVE
VAAQPFPCKI--FSSQKPKKTKVKLTKVKQPGQPVKH-TFRSQAV-------------GD
SVPLIWSQLQSSEDQMEVTRN--KSDLDACSERPE-PLIDVS------------------
------------------------------------------------------------
--------------------------------------------DKTSVTIR---T----
--IFSIVSK----TTNQAH------KSD-----SEEDTGRDPR----METPTKCISQNNS
CLPV-VDSDHLDTLLWPPNID-----HLMGIPSNTVTS---LNSSFPAAF-YIFPPS---
--------PSFLK-SKD------------KARSTISKKHARP-----LS-SHKAASVPIE
SGK------MPFIL---DQ--SNKVPAK--------------------------------
----------P------APAQMASALPIPSPK----------IPTSQWSR--QKSSATPS
-CFYKSQPS--VSQKTPTIPGHPQKPQVVTAPTQKTLTLNQKF-LQALAHPQKAM-----
-HLKKDHLLINTRSQKD-PTAQYQK-----ALDSRAKDLVNPSTL--------QGGDML-
ERKTEGKQEPVL---L------------VGEQNKKVVDMRAQTMSVNLPFA--TTKKQSK
EILISKTQEVTLEALKGREKLEDRVHKME-EETTVNLPGLKSKETEMQKKWVLNKEVAFE
GPYTEDNRPFSVEGLALAKMMIMANS---KHQ-HLKPA-TISLPSSFPMTNKVSSMSVLA
--NLPYNTRQMTFPERTQVVIVEKSGSHTKVNKEKTQHQKERKLPEDLLSTAQK------
----------------------PI-----SLDDKSEPLTSFTSSISPTSETKTSVKVPQK
PVVKHQGLK-----------------------------------------AQSQHHPSLV
TRSTSEILLPVNLRTENKGKTATKAEMPVKESGARHTQQRPKDLR---------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-PTMRIN--KQDAVCTPH-SHDPGHL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TEPL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDAE--------NMRLKVKLVSGRAYY-------LQLCAS---ACKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMDVMDIT-----AFTAIA
TPYMYAGTGPVRVRDSIDFSEFTGITDI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVTEVTE---ATEV-------TEN-LDVTKCSGV
TVVFENDDLIR--AKQEEEEKTKDILKPGCLQDTK-SKSELKE-----------------
---------SP--------------------------------------------K----
--------------------HVTISN-ITVTFEGKGYFQTTLTPVESEANTS---K----
--EME-DKTSEEKTPDFKSTALKAEESRSLRTESNTSVL---SPHIKS------------
SSNFLKLVPHLSPL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSFPHRKT-WRKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CQVVHSP-EFN-LFPD-----SVVFES------NFI--Q---------------------
-V------------KR-GRNWRDVYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHQGQ-------------------NQTWNRP-SVAPNIFL---KRILPL-----
KFVE-LQVCDHY--------QRILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCSSPSGD-SKL-VQKKFQASQ
PSESL--IQLMTKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQL--RSSRKV-------ETNKN
SSGK--------------------DSSR--EDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALAFS-LRA----
-G--S-DPR--VLR-----VIPESCGVWS--RNAGHRDLSP-LFPTGLSKTMMCGTSRAP
RVP--------------PDAVDAIDAFSCCMGGV------RDLLCRLPMWSFLSFPFLEL
L-----------K----------------------------GLLTAWVG-MQRVKRK---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSSECLLPY-YTANSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVGIASTSPILPL----PDV--------M
LLARPTKVC-EEHVRH-------ART----TKGRGR--KPTKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVESCSST---PTLQ----TGDARI-L-----EGDKSL-------L---
------------------------------------------------------------
------------TAEL------------HRERE---HDAV----G---LH-KL-GDVSGA
SSC-AY---------VGGEGAYHAPHGSTASLK---STEGGAAG--T---TS--------
------------------------------------------------------------
--------------------GLAIAGTTTSSGGGVAVAGLGAGS--VGGAVS-LAA----
-TR-SSSTS-QVST-TLAGA-------------------------ATK-GSGESGSGKAT
VGA-------ASI-SSEGTNLVLAGAASTSSTGVD-----------SADS-SMSVVFAGA
MT-TGKAAAASAE--GRVV------------APLVSTLQSEGYMSERDG-SQKVSRPRDE
TRK------EKKER--REKKDKSS--SRKSSRHRRTG---------------------EG
HHRTGGDK-TRKSSSHRSVSGHGNKRD--------------------DKK--EKGQSGTR
-GKGH--SPHKSGSHSSSGKEGRT-----ARKPGKSRSSTSSG-----TLNK--------
-RSSKISTFFRSFRVIPGSKPMV----------GHDR---EVDFVAKTVE-KRNVEAKVE
KAPVGEDVE-IH-GTVTSET-------------METIIIETKSV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPHRKT-WNKSK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-FPVDGEPN--PGVGL-----GVEEGLL
GQMVHSP-EFN-LFPE-----SVVFES------NFV--Q---------------------
-V------------RK-GRDWIDIYKTYNTMALGVTSSVPCLPL----PNI--------L
LMASVKWHHGQ-------------------NQTWNKP-STAPKIIL---KRILPL-----
KFVE-LQVSDHL--------QRVLRLRTVTEKIYY-------LKLHPD-----HPKTVFH
FWIRLIQILQKGLSITTKD---PRIL----VTHCLVPKNSCSPSGD-SQL-VQKKPQASQ
PSESL--MQLMAKGESEALCQIFV------------------------------------
--------------DLHQ------------------HNLFSSRSSKK-------TENKKD
SS-G--------------------KKTSPSEDSIP--CT----------RDLSWRDSFTY
GEWERENPS-GPQS--------------LSLLSTLAASTGPQ------------------
----------------------------LAPLIGSSI-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSI
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSPPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTVGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MSG-----------------
---------------------VKRTLSSEYALPY-YTAHNY--RSVGLFN----TSMGDL
QRQLYKGGEYE-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNHVRMVTVCIMSTSPILLL----PDV--------M
LLARPAKVC-DEHTRC-------SLL----TKKRSQ--KPKRTLEL---TRLLPL-----
KFVK-LSIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTRADLFC
YWEKLVYLLRPPAGSCSST---PMDQ----TGDAAT-P-----KD-KSL-------L---
------------------------------------------------------------
------------GSDL------------HGEGD---QDS-----M---VL-KL-HEVRGA
SSS-AY---------AGGEGIQQAA---AGS-----------------------------
------------------------------------------------------------
----------SKGEVAGTMSGVAVLGATTSPTAGMAMAGTVMGP--EGGATN-MAV----
-AK-STGLS-QVTT-AVAGT-------------------------ATK-DTAEGGSSKAM
AAA-------ANI-SSSDVNVVLVGAANTSSAGTS---TVVGTAGVTQDN-SVSVVFAGA
MT-TRAPVAEKAE--GSEV------------APLVSTLQSEGYMCERDG-SQKVPQVNAE
ARK------EKRER--REKKNRNA--SKKTSHHHRTGESH--------------------
HHRGDGDK-SQKSSSHWSVSGHGNKRT--------------------ERK--EKGQSKVR
-GRGHG-STHKSSSHSSANKESRT-----SHKLGKRRSAASSC-----SLRK--------
-KSSKISSFLRNFITVLCSKTAL---------ISRER---EGDVMAKKVE-KCNRDEDG-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPEV-REPG--PGVEL-----GVENGLL
CQLIHSP-EFN-LFSN-----SVVFES------NFI--Q---------------------
-------------VTK-PGNWRDVCEGSATMILGVTSSVPSLPL----PNV--------L
LMANVTWPQGP-------------------FTTWSTP-GDAPVINL---SRLLPL-----
KYVE-LRIYDRL--------QCILRVRTVTEKIYY-------LKLHEK-----HPEIVFQ
FWVRLVKILQKGLSITTKD---PRIK----FTHCLVPKMPTNSTET--TP-ENSLLSSPQ
PSEPL--VLLAAEQTSGSFSQLSG------------------------------------
--------------KPQL----------------------TADRNND-------TAIEID
NCSS--------------------Y-KIPSPVASP--IN----------LNIPMRAALSH
SLWEQEDRN-EHFL-----------------QVHIASYLG--------------------
----------------------------------EHFLGA--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------M----
-------------------------MK--KN--R-NKKAMN--KQEALFIPH-YYRLGHL
KNILDGG-EYA-PYVS-----PPILES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSNPIF----KTPNM--------M
LLAHLTPEARKE-----------PEPL---FKTLLKS-SSSGTLVL---TRFIPL-----
QFVT-LSVHSAK--------NMRLKVKLINGRSYY-------LQLCAP---VYKQDIIFS
QWVDLIPLLNQEKIKNT--KVSEVSS-LSELTNST--DITGSMDITDIT-----AFRELR
PRHPKTHRYPCNIMESADFSEYTDVTDITDVTDVPDMLDNGI-TD---VQDIK-------
---------I-----V---------TEVT---------EV----SEVSDV-KMATNISGV
KIVFENDDIIK--TKQEEKE---YTLKHRSLRDTK-TKSDYRD-----------------
---------SP--------------------------------------------N----
--------------------PVTMSN-IALALQDEGCFQTTQTPVKSKEDIY---K----
--EIC-DETSEENMIRLQNIHLKATESRSTRTDSDISD-GELK-----------------
----LGRYLHKQYSSREQSF--------------------IHSLGSLPRG-FVFLHL---
----------LL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEDHCMLPY-YTAQSS--PAMGMFN----TSMGKL
QQQLYKG-EYT-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNASC-------GPA----TQKRDS--PPTEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---KAIL----AGNTL--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLSPEV-REPC--FGVEL-----GVENGLL
CQLIHSP-EFN-LFPN-----SVVFES------NFI--Q---------------------
-V------------TK-AGKWMNVCADSTTVILGVTSSVPSLPL----PNV--------L
LMANVTWPQGQ-------------------HSTWNTP-GVTPIITL---SRILPL-----
RYVE-LQIHDRL--------QRILRVRTVTEKIYY-------LQLHEK-----HPEAVFQ
FWIRLVRILRKGLSITTKD---PRIR----FTHCLVPKLPRLSTET--TP-GSSLPGSSQ
PSETL--LLLAAEQTSGSFSELSG------------------------------------
--------------RTQL----------------------TADRSTN-------TAIKID
SSSN--------------------Y-KRLSPVVSP--IS----------VNMPMRATLSH
SLWEQDDPN-EHLL-----------------QAPVASSLG--------------------
----------------------------------ENFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSNESCLPY-YTARSY--YSMSAFK----TSMGDL
QRQLYKRGEYD-IFKY-----APMFES------NFI--Q---------------------
-IN------------K-KGEVIDVHNRVRMVTVGIVCTSPILPL----PDV--------M
VLARPTKIC-EEHVRQ-------GWF----AKGRGR--RPVKTLEL---TRLLPL-----
KFVK-ISIHDRE--------KQQLRLKLATGRTFY-------LQLCPS---SDTREDLFC
YWEKLVYLLRPPVESYCST---PTLL----TGDTAP-------EDNKSL-------V---
------------------------------------------------------------
------------AAEL------------HRERD---QSET----G---LH-KP-CDVSAA
TSS-AY---------AGGEGIQRASHRTASAASLSRSTPGTAEGA-A-------------
------------------------------------------------------------
---------------ARTAGGIAVAGTATGPRTDVAIAGAATSP--ATGAVS-IAA----
-TK-SAGPG-QVTT-ALAGA-------------------------AIK-NPGENESSKSM
AGA-------ANI-SSDGISLALVGAASTSSAGTS--TSMAGTTSLSQDS-SLSAAFAGS
MT-TSKCAAERTE--GPAV------------GPLISTLQSEGYMSERDG-SQKVSLPSAE
AWN------EKKER--REKKDRHP--SRKSSHHRKAS---------------------ES
HRRTAGDK-NQKPSSRRSVSGHKNMRD--------------------DKK--EKGHSNVR
-GKRHS-SSRKSSTHSSTKKESRT-----THELGKNRSASSTG-----ALRK--------
-KASKISSFLRSLRATPGSKARV---------TSHDR---EVDIVAKMVE-KQNIEAKVE
KAQGGQELEMIS-GTVTSET-------------TETIIFETKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MLSSVPRRTP-WWKPK---KTVQV
TRSYPTFP-------------ALNAWEEFRGL-LAVDGEAN--PGVSM-----GVEEGLL
CQMVHSP-EFN-LFPD-----SVMFES------NFV--Q---------------------
-V------------KK-GRNWTDIYKASNTMALGVTSSVPCLPL----PNI--------L
LMASVRWRQGQ-------------------SQTWNRP-STAPRIML---KRILPL-----
KFVE-LRVYDRL--------QRVLRLRTVTEKIYY-------FRLHPD-----HPETVFH
FWIRLLQILQEGLSITTKD---PRIL----VTHCLVPKNYCSPSGD-TKL-VQKKPRAPQ
PSESL--LQLMAKAESEALSQIFA------------------------------------
--------------DLHP------------------QNQFR--SSKKVET--K-K----D
--GS--------------------GSSI--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------LAMGSDCLSPY-CKAQIS--SAMGMFN----TTMGLL
-CQLYKG-EYD-NFKY-----APILES------DSI--Q---------------------
-IS------------K--GEVADEYNRVGMVTLHIACTSPTLPL----PDV--------M
LLASPATCC-EDHVVQ-------GQA----IKGRGH--KATKTLEL---TRFLTV-----
KFVR-ISVHELE--------KQQLRLF---CRSCN-------LQLCPP---LHAKEDLFT
YQEKLMYLLHLPVDTNSST---HAIP----LGTRY--ACLGWRKRPGRA-------Q-L-
------------------------------------------------------------
----------------------------RPTAR---ARGT-MTRS---LH-IV-SQVSGA
SSS-AYDR-----GGGGGEGIKYAPHKPTTTPDTAKPTSPAKGAA-AG-TI---------
------------------------------------------------------------
------------------------------------AVTVAK--GAVASTIS--------
-----GADT-EHSR-AVARA-------------------------ATK-GPWHSKSSLAV
AGV-------ATV-PSKNIKVAVAGAASQTTERT---VSTEGSTPLSREQ--PERGVPGA
AA-VKQPGAETAQ--DSAAA------------------------------RGPQDQTKQE
ARK------ERRER--RELRGKDRAPSGQSSRRHRTG---------------------D-
SSKSGSHKVSEQSSGGS-LTSRRSPGE--------------------EQK-EKA--VAAE
-GAAGA-AP-----RTRAS---AA-----SPSSGRSLSTVSSS-----STSK--------
-RLSSTSFFLRNLKASLCNKSAA---------QRCPR---DVDIVSKRVE-RSSREAILQ
TTECDQEVI-I--GARMLDT-------------VELVTFEAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------MPG-----------------
---------------------MKRTMSSECLLPY-YTAHSY--RSMGVFN----TSMGNL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPVLPL----PDV--------M
LLARPAKVC-EEHARR-------ARF----IKGRGY--KPSKTLEL---TRLLPL-----
KFVK-ISIHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPVNSCISN---PSIP----TADTST-E-------TKST-------L---
------------------------------------------------------------
------------VSEI------------HGEGD---RDS-----K---FQ-TS-QDVSEA
TSA-AF---------AGGERTQPNIAAILTTGLAKARAAGAAAGT-GA-AG----TAGT-
A---------GAAGAT--GAAG-ATGAAGSAR----AAGG-AGS-----ARAAGATGSAR
AAGATGSARAAGATGSARAAGGNTAAAVMTPLAGLARAGTPTSP--VSGVIS-IAAT---
TSK-SPGSG-QVAT-GLTGT-------------------------ASK-DQERSESSKAM
AVV-------ANI-TTESVDVVLAGAASFTSESPS----AEGDAYGSPDT-GLNVAFAGS
IT-TKGPAEDK--PE----------------APLVSTLQSEGYMCERDG-SQKVSHTSSE
TQK------EKRER--RE-SDRKG--SRKSSHHQRTGAS---------------------
RHSSSKDK-GRKTSSYRSVSGHGKTRE--------------------DKK--EKGRGSLR
-DQRHSS-SYRS--------ESRT-----GHKSRKNRPAASGG-----FVSK--------
-RATKIRSFFRAFLVRPTLKTEN---------TSGER--GGVDIVTKLVE-KQDIETTVE
KS---KDLE-FS-DTMASES-------------MEKIILETKPI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------PGQQLLLPY-F--MAQ--SGCAVG----LFNTGKL
QRHLCKG-EYD-RHLQYSCLSSPLFHI------SFI--Q---------------------
-SP------------K-GGGVIDVHNHPRMATVG-------I----ASTSP--------L
LLARPATSCHDHVG--------RGQA----TQGRGR--KAAETLEL---TGSCPD-----
-VVR-ISVHDRQ--------KQQLRLKFAPGRSCF-------LQLCPP---LHARETSF-
HWEKLIHLRCPPGDSRRST---HAVP----LGTTR--ARV-----------------GGR
GGA------------------------------------SPA-LPLQGQGGQD--QVSLR
SLLTASGV-SGASSAYA-------------------------------------------
-----------------------GGRGSNMPPKPT-T---KPDTA-K-----PTRP---A
TGAAA------------------------------GAGAG-A--------AAN--T----
--------------------E-------------------------HSTAVA---G----
--ATAKGPG----DS---------------------------------------NSSLAV
AGV--ADVP------WKNIKVAVAGAASQAPERTASA---AGSTALC-RA-QLSLALGRS
SGH-QPGAGTAQD-SA-------------VGPPEDRKTQQEARKERRER-RERRDKDRAP
SRT---------------G--SR----RH-----SAG---------------------DS
RSTSGSRK-GR-SSGRSLSSRRSP-RE--------------------ERK--ERGRGSPG
-RSRRSSAHEGVTAR--------------RHQSGRSPSRVSAS-----CTCE--------
-RLGRSSSSLRRGKAPLGPSPPP----------SSSRNVD---LLPKRVE-GSSVEAILE
AA----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MWFSPEWSI----
-------------------------MKKINR--K-S---TN--EQDALCTPQ-PCSPGGL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNRANWVTVGICSSSSTQ----KTPNV--------M
LLAHLTPAAKKR-----------SEPL---FESLLTS-PSTGKLVL---TRFLPL-----
QFVT-LSVHDAK--------NLRLKLKLVSGRAYY-------LQLCAP---PYKQEALFS
QWVDLISLLNHEKIKVL--KASEVSS-FSEITNST--DITGSVDIMDFT-----EFSTIQ
NPHPYTWTEGIHVMDSLDFLELEDVTDV---TDVTDVPENEV-PE---VPDVN-------
---------I-----V---------TEITEVVE---ATED-------THS-SDASNFSGV
TVVFENDDIIR--AKQEEKEIVEITMKPGCLRDTK-SKSEFKE-----------------
---------SS--------------------------------------------K----
--------------------HVTISD-ITLTFQGERCFHTTLSAARSEAKIS---K----
--EMS-DKISEEKTTDLKNTVLKAVDSRSMRTHSHPSGL---YSFSVFPL----ISISFP
LFT---L---LLFI-FPHSY--------------------T----------LTLNTT---
----------LFP-AKA------------KS-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MKLDGESQ--KGQEL-----E------
------------------------------------------------------------
------------------RHLQSLLHHG--PGGDLLS---ALPA----PP----------
----QHPTHGQ-------------------CQ----------------------------
--MA-PGVCDHHQR--------ILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLVQILQKGLSITTKD---PRIL----VTHCLVPKNCCSPSGD-SKL-VQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLHQ------------------QNQLRSSKKVETN-----------
KNSS--------------------GRDSSREDSIP--CT----------RDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-GGIPCHCGAALVFG-LRA----
-G--S-GPG--VLR-----VIPESCVVWS--RDASHRDLSP-LFPTELSKTLMRGTSRAP
RVP--------------PDAVDATAAFSCCVGGV------RGLLCRVPMWSFLSFPFLEL
L-----------K----------------------------SLLTA--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MKRTMSSESLLPY-YTAHSY--RSMGVFN----TSMGDL
QRQLYKGGEYD-IFKY-----APMFES------DFI--Q---------------------
-IS------------K-KGEVIDVHNRVRMVTVCIASTSPILPL----PDV--------M
LLARPTKVC-EEHAKQ-------GRF----TKNKGR--KPAKTLEL---TRLLPL-----
KFVK-ISIHDHE--------KQQLRLKLATGRTFY-------LQLCPS---SDAREDLFC
YWEKLVYLLRPPAESCSST---PTLQ----TGDATT-I-----DDDKSL-------V---
------------------------------------------------------------
------------ASEL------------RGTGS---PDG-----G---IH-KL-REVSAA
TSS-AY---------AGGEGIQVAAVSATTST-----SGAA-EGA-AG-TAG--------
------------------------------------------------------------
--------------------GLAAAGAATGTTAGAAVAGAAASP--TAGAVS-LAT----
-TK-STGSG-QVTT-ALAGT-------------------------ASS-DSGEGGTSKAV
AGA-------ASI-TSDGMNVVIVGAASTTSSA----VNSPGASSVSPES-SLSVVFAST
VT-TNVPTAEKKEG---PS------------PPLVSTLQSEGYMCERDG-SQKISKIHAE
VRK------ERKER---DKKNRNT--SRKSSRHRRTG---------------------EG
HHRTGGDK-NRKSSSHRSVSGRAR--D----------------------D--KKGQGNVR
-SRGH--GSHKSASHSPTTRESRT-----AHKPGKSRSATTSS-----SVSK--------
-KSSKIGSFLRSFRAIPGSKMAD---------TSHDR---EVDIMAKTVE-KHNIEAKVE
KDKDGQELG-IT-GTMTSEM-------------TETIIFEAKSI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MIW--LRNR-RRLEPL--QGTPKW----VPVQGEL
QKTLQKG-EYL-PLCP----L-PMFES------NFV--Q---------------------
-VT------------H-QGGPVFVNHRTNRLAMGVAASLPGL----VLPDI--------L
LIGQPAE--D----------------------------RDCSGLVL---TRMIPL-----
DLVH-LCVHDLS--------AWRLKLRLVSGRQYY-------LALDAP---DNEAGFLFH
CWIRLINLLQEPPPTWAPR---TMRT----A--SL--DVP-----------------LA-
------------------------------------KAPAST-WHLQDQPVSR---HAVR
VAEHNSPYKKSLVATRRQRKAK-----------ALKR-SFKSQAV-------------GD
SVPLIWSQLEHADVRKKPAEK--KSHPDSRPDRTH-TQVH---F----------------
------------------------------------------------------------
-------------------------------------------SENTSITIW---T----
--IFSIISS----TTNQAQSSPKACTSA-----ADEATGQGHV----VESPSCCVSADSP
DCFFLGSCSSLDPCLWHQDME-----DLMDSESSTLSSAASGLAPYPPAA-CLSTPY---
--------SSIPR-GRE------------KARPMGSHEGPGP-----PP-CQKAPAAPVT
SCK------APFLV---DQ--SQKLPAA--------------------------------
----------P------ASSWKPPPGLAPPQKVPAASAPPWKAPAVPAAS--QKA-----
----------------PAASAPPWKASAVPAPPQKTPPPSQKA-PSVPTIPQK---AVSP
TAPKRKSLLLPAPSQKALPTSPPQYQMALGSPASWGRLPGDFGVL----PTGIPARAVLE
RSQSGGKPEPVV---T------------AGTQGTDVVEMTTQVKSLESPFT--MTKKESK
DILISKTQEVTLEAFRGQGKLEDPAHLAKLEERSLDLPGVRSKELEQQKRWVKTKELAVE
GPSQEHSRPFSVEALTPAKLTIMANS---KDQ-RVKPA-LVSLPSWLLVTSQASATSMMA
--SMPFHPGQLSSPEGKPVVVREQPKSHTWVKEGKRQWCDS--------KGSPWDPEGP-
PKVPLRSKPTSASPKREGISQPPIPLPASRWEGL--LPSP--LSETPISKTEATAKASQQ
PKRLSQEPV-----------------------------------------KMPAQHPLAT
VGSSSEILLPMLLELETVRNTATKAEEIQEESGVLNLPPSLQHSQHFE------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------PVRGLFN----REMGPL
QRQLQQG-EYS-LLKF-----APMLES------EFL--Q---------------------
-IN------------K-RGDITDVHNELQTVTVGVACTSPNFPG----PNV--------L
LLARPVLSP-EERPQK-------LNT-----LRRRR--APAKKLELTRLWRLLPL-----
SFVK-ISVHNAE--------KQQLRFKLASGRTFY-------LQLCPQ---LGAQDDVFE
LWVKVINMVRPPSTVFSYP---SYVK----ALSTPD--SSNLEETESIP-------S-V-
-------Y----------------------------------------------------
------------TPEL------------VSPIQ---EDAR-SRRS---M-----------
----ALSM-------GGPPSFHPLSHS---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------MGPL
QRQLQQG-EYS-LLRF-----APMLEN------EFL--Q---------------------
-IN------------K-RGDVADVHNERQTVTIALACTNPNFPG----PNV--------L
LLARRVLSP-EEQPPK-------MKT-----LQNRR--APV------NLFRLLPL-----
TFVN-ISVHNAE--------KEQLRFKLASGRNFY-------LQLCHQ---LGVQEDVFK
LWVKVINMLQPPSA----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNTS--K-STMRIN--KQDALCTPH-SHDPRDL
QNMLDGG-EYA-PFVS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYLHNQANWVTIGICSSSSTH----KIPNV--------M
LLAHLTPGAQKD-----------TETL---FKSLLTS-PPAEKLVL---TRFLPL-----
QFVT-LSVHDVE--------NMRLKVKLVSGRAYY-------LQLCTS---AYKQDTLFS
QWVALISLLNQEKAKVS--KVSEVSS-LSGITNST--DITGSMDVTDVT-----AFTEIL
TPYMYAGTSPEHVRDSIDFSEFTDITNI---TDVTDLPENEV-PE---VPDVR-------
---------I-----V---------TEVIEVRE---ATEV-------TDS-SDITNCSGV
TVVFENNDLIR--AKQEEKEKLKNILKPGCLQDTK-SKSELKE-----------------
---------SS--------------------------------------------K----
--------------------PVTISN-ITLTFEGKRYFQTTLTPVESEANTS---K----
--EME-DKTSEEKMPDFQSTALKAEESRSLRTGSNTSVL---SPHIKS------------
PSNFLKLVPHLSAL-FSRE-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MKKNKG--K-SV---------------DXRGPGHL
QNMLDEG-EYA-PFLS-----PPMLES------NFI--Q---------------------
-VN------------R-RGESIYVHNRANWVTVGICSSSSTQ----KTPNV--------M
LLAHLKPTTQKH-----------EAQL---FENLLAS-P-TEKLVL---TRFLPL-----
QFVT-LSVHDAK--------SMRLKVKLVSGRAYY-------LQLCVP---ANKQDALFS
QWMDLISLLNEKKAKTS--KVSEVSS-LSEITNST--EVTSSMDIMDIT-----AFTNAQ
ATHMYL---PVHVTEGMNFSEFTDATDI---TDVTDIPENKV-TE---FPDIK-------
---------I-----V---------TEVTEVIE---ATEV-------KSI-SDATNSPGV
TVVFENDDIIR--AKQEEK--VYSVVKTSCLRDAR-SKHEFKQ-----------------
---------SS--------------------------------------------K----
--------------------HVTISD-ITLTFEGERCFQTPLTPLKSEADLC---G----
--ELT-EATSEEKKTGFKNTALKTLEARYVRKENPLI--HSLNIYRAPPM-----RWVLR
IWQ---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSRESLLPY-HTAQSG--AGAGLFN----TTMGKL
QRQLHKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIASTSPLLPL----PDV--------M
LLARPATGC-DDHAGR-------GQT----TKAKSR--KAAKTLEL---TRLLPL-----
KFVR-ISIHDRE--------KQQLRLKFATGRSCY-------LHLCPP---LDSREDLFA
YWEKLIYLLRPPVDSQSST---YAIP----AGDMI--CMPMFEE-DRRS-------P-A-
------------------------------------------------------------
------------AMDF------------QGRGD---QDQV-SVRS---LH-VG-SEVSGA
TSA-AF---------AGGEGLPLDFYSPDPMPDGAMANTKPRELD-EE-SA-A-------
------------------------------------------------------------
---------------G-AMMQVAAAD---------ATEGN-------------LNVT---
--K-SHASE-EQST-AIEVT-------------------------VTK-GPEGSKSNIAM
AGV-------AKT-SLRTRKTALAHGAKNLEYPS------STSTSLSPEA-SMTMF--GA
EA-TRKTAKGKAD--QEDE------------GTLISALPQEDQESEQEERPRRVS----Q
ARR------GRRER--RERREKERALR--GSRPRGSA---------------------EG
RHKTVGDKAIRKTAGRS-SGGRRATRD--------------------DKK--EKGHGSPG
-DSKRG-TVHKGVSHAPITKESRT-----SHKSARSLSTGSSL-----STNK--------
-RLSRISSFLRNVRANLTTKTVA---------LSHNK---DVDILAKAVE-RKRMEAIME
TAESGQGLE-IA-GSVTSEA-------------TETVTVAAHQ-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIPGLPPEV-REPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------IFI--Q---------------------
-V------------TK-PGNWMDDCEGPTTVILGVTSSVPSLPL----PNI--------L
LMANVTWPQGQ-------------------FSTWSTP-GSAPVITL---SRILPL-----
KYVE-LRIYDRL--------QRILRVRTVTEKIYY-------LRLHEK-----YPETVFQ
FWTRLVNILQRGLSITTKD---PRIR----ISHCLVPKLPCRSAE---TS-ESSLPSSSR
PSESS--MLLAAEQNSDRFLNLSG------------------------------------
--------------TSQL----------------------TVHRNTN-------SATEIE
TFNC--------------------KDNTSSPASSP--VI----------SNIPMRAALSH
SLWEQENAD-EYHI-----------------QAPVASSLG--------------------
----------------------------------ENFWGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MSSVPHRKT-WRESK---KTVKV
TRSYPTFP-------------SLNAWEEFRGL-LPVDGEPN--PGVGL-----GVEEGLL
CPMLHSP-EFS-LVPD-----SAVFES------NLV------------------------
--------------KA-GRNWREIHTASNTTALGVTSSMPCLPL----PNI--------L
LMANVKWHQGQ-------------------SQTWNRP-STAPNIFL---KRIFPL-----
KFVE-LQVCDRH--------QCILQLRTVTEKIYY-------LKLHPD-----HPETVFH
FWIRLTHILQKGLSITTKD---PRIL----VTHCLL---------------EQKKLQASQ
PSESL--IQLMAKGESEALSQIFA------------------------------------
--------------DLLQ------------------QNHLSFRSSKKV-------ETNKN
SS----------------------EKDSSGEDSIP--CT----------CDLRWRASFTY
GEWERENPS-GLQP--------------LSLLSTLAASTGPQ------------------
----------------------------LAPPIGTAM-EVIFCHCGAVLVFS-LRA----
-G--S-GPG--VLR-----VIPESCEVGW--SDVGH--PSP-LFPTGLSKTQMCGTSRAP
RVP--------------QMLLTLQL-------------------LCFALWEM--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNR--LQNI-RHMEPF--QGPSKW----VPTLGEL
QKTLQRG-EYL-PLRP----L-PMFES------NFV--Q---------------------
-VT------------N-RGAPAYVHHRTNGVTMGVAASQPGL----VLPDI--------L
LIAQPPE--G----------------------------RECANLVL---TRMLPL-----
DLTR-LYVHDLS--------SWRLKLRLATGRCYY-------LELDAP---RNEAGFLFD
RWIRLINLLQEPATTWLPR---TPHR----P--AR--DPA-----------------SV-
------------------------------------KPPAST-WRLQDQPQSG---RLVM
TVEPNFPYKM--LTLQKQRKAR-----------TLKR-KFKSQAV-------------GD
SVPLIWSQQEHAEPRKKSAEK--KSQRNLHPDTSQ-TQIQVT------------------
------------------------------------------------------------
--------------------------------------------EKPSITIR---T----
--VFSIVSN----TINHTQFSSKCCSSD-----SDTATVLGGL----IETPIGCASADTP
DISLLESYDPFNTYLWQQDIE-----NLMDPDTSTLSLSSFSPATYPPRF-SLPAAY---
--------SSSHR-RNE------------KAQALGSGQRQRP-----PP-SQKTAAARVA
AWK------VPFLR---DQ--SKRVSAM--------------------------------
----------H------DPSQKMSTAPGPPRG----------PPVVPAVT--QKTPTVHG
-PPWKAPPVSVTSRKAAASPGPARKAPPVSPTSRKAVSSS--------------------
-VPGRKSVFLPAPSQKA-LTSPTQQQMTPDA--------ATLGTL----PTGGPRGCVLE
RSQREGMPGPLM---F------------VGTQEMDLIETRTQKTSQDLPFT--TTKKESE
EVVLTKALKITLDGLKGRGKLEDKVHRKK-EEISLDKPGLTSQTVGQQQKWLKTQEVVIQ
GPPEEQSRPFSVEGLTLAKLMIMANS---KEP-PLRPA-TVNPSSWLSNPPMPDMST-V-
---SPSEVPLPQGT---PEVVGEQSLFGTWVKERMHPWAEGSMYHWVEAQPQVPK---EA
SEVPGLPRHEASSLMMDNVPPDPISLPASRWEEA--PLWP--ISLTPISEMKAS--VFQQ
PKRASLEPERQSDQLEGRSDQLKKTPDQFEGIPDQLERIDQLKRMSDQLEGMSDQSPLAI
TKLSSDVILPTLVENENMMDMAPEVEDIEELG-VYSPSA-SIQSSQSL-H----------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MSKIRGLPPVV-RDPG--PGVEL-----GVEDGLL
CQLIHSP-EFN-LFSD-----SVVFES------TFI--Q---------------------
-V------------TK-QGHWMDAYERSATVILGVTSSVPSLPL----PNV--------L
LMANVTWSQGQ-------------------LNTCST--PGAPVITL---SRILPL-----
KYVE-LQIYDKT--------QRILRVRTVTEKIYY-------LRLHEK-----HPQAVFQ
FWIRLVKILQKGLSITTKD---PRIQ----FTHCLVPKMPNSSTTT--TP-ESSLPSSSQ
PIETL--MLLAAEQTTSSLLGLSR------------------------------------
--------------KHQL----------------------TGARQTD-------TTTEAD
NHN---------------------SYKSPSLVASP--------------INIPMRATLLH
SLWEQEDPN-ENFL-----------------QAPVASSLE--------------------
----------------------------------KNFLGP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MNSDSLLPY-YTAQSG--SRVGMFN----TAMGKL
QRQLYKG-EYD-IFKY-----APIFES------DFI--Q---------------------
-IT------------K-RGEVIDVHNRVRMVTVGIACTSPSLPL----PDV--------M
LLARPATNC-DEYAGR-------GQA----TKGRGR--KATKALEL---TRLLPL-----
KFVR-ISVHDRE--------KQQLRLKFATGRSCY-------LQLCPP---LDARNDLFA
YWEKLIYLLRPPVDSNSST---YAIP----AEDL---SMPVLDEDGT-S-------L-G-
------------------------------------------------------------
------------AVDL------------QGKGD---QDQV-SIRS---LH-MV-SDVCGA
SSA-AY---------AGGEGVQHDSHKPTGGSNVSISKKKSAELA-KK-SSTR-------
------------------------------------------------------------
-----------------VTKETAAAG--------------TA--GATVSTSS-VPVTSVP
VTK-CVSPG-DVR--SIAGD-------------------------ATP--EAEGSSNIAI
AGS-------ASR-SSAF-NKAIVKAASKSSENI---S--GISSNL-PTEGIMSVTIAEI
ES-TSKIAVEVEN--SPTA------------GPSITTLLREHSETGTHRRQR--SQTSVE
GRKERRERRERRER--RERREKDRALGGRSTHHRRTG---------------------ES
RRKTSSDKVARKSPSHS-SSSHRASRE--------------------DRK-DKGRS----
-------GSHKGVSHTPITKDSRT-----SHKSGRSLSTASSG-----S-SK--------
-RLNRISSFLRNVRANLTTKAGG---------SPRGR---NVDIVAKTME-RNTMEAIVE
AGESGQDLE-VV-SSVTSEI-------------METVTFTAH------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MEDCCMLPY-YTAQSS--PAMGMFN----TSMGKL
QRQLYKG-EYS-IFRY-----APMFES------DFI--Q---------------------
-IS------------K-RGEVIDVHNRARMVTVGIVRTSPCLTL----PDV--------M
LLARPAAVC--DNARC-------GPA----TQKRDS--PPAEILEL---TRLLPL-----
MFVK-ITIHNSI--------KKQLHLKLATGRSFY-------LQLCPP---SDASEDLFV
HWENLVYILRPPVEAYSGT---RAII----AGNTL--DSSVFEEVQRSP-------VG--
------------------------------------------------------------
------------YAMK------------FCEE----KEQF-RISR---LH-MN-AEMFGS
TYY-DY---------TIEI-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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-------------------------------------------------

Query Results

"ENSGT00530000063078"

ENSGT00530000063078