ENSGT00530000062932_0 : Linker Region Query Results

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-V----GA-----------------------D-------------STHEYYCSSLPQLKE
YWQRKS---PGVP-----AGAKRNR-------KTNGSG--PETA-----------TADGC
HSPGD--SAT-GIHGEGPTSSAT---------------------------------LKDL
-------------ENPCQEPAVVLD-------LRSVK-------------ISQ-------
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------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-KRELEVQIQRLNIQ---
KEKLN--------TDLYY------MKRSLRYFE---------------------------
-----YESKDVAGCLQHSLQRIAELEWALSLL----------------------------
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---SLRGKAVIEWQ--------LEQSIGE-Q------------------LKELVKQVQLE
RDEYAQ-HIKGERAWWQQRMR--KMSPEGSSD------------PSV-CTL---KKEKK-
--------------------------------------------HDTHRVEKLE-RSLSK
LKNQRGPYCLLPF-SAEPLPLE-P---PAVPSEV-------------E--------LQHL
RKEVERMAGELQAQ-------------VDNN--QCMSVLIWGQK------ERLQQQE---
----E-R--------------------------------------------------LQ-
-----------------------------------------QQEERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEQQVKELQE
KLS---------------------------------------------------------
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--------------------EERLEAASQQN-QPLQAQLSLT--ALPGEGDGGGH-----
------------------------LDSEEEEAPQPM-PSIPED----------------L
EIWEAMRGLT--------------------------------------------------
-------------------------------------------------------DLLEE
KADLREWVEKL----------------------------------ELRFIQYWK--DRRH
Q-KVLHLIMEPGGSAKDAAPGGGLHQAG----PGQGGDESEA--A-GAAG-DNDVACGD-
YNKGHSKFPATAQNP-ADEP-SL-----GAPAPQELGAADKHVLRQVGRQGQERLALRSD
PCLPLP-------KDLCE---VSL--TDS-------------------------------
--------------VEHPG-LGINPCVPFFCRAWLPRRRR--------------------
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---------------------------------LWPQPHLPF----RPR-----ADSS--
HD----DYCS-------------------SFP-------------QLKEY----------
WQRNS----PAVP-----GEAKSNR-------KTN--GSNPETS-----------TSDGC
HSPG--DSAT-GIHGVGPTSSAS---------------------------------LKDL
-------------ESLCQEQAVVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEAQIQRLNIQ---
KRKLT--------IDLYH------TKRSLMYFE---------------------------
-----EESKDLAARLQRSSQRTEELERALSAVAATQKKKKVDRVSSP----D------RN
FSLF-----------------------------------------------------TIQ
--SLNRSKTLLKTQ--------LEQSLQE-RALLKAHVT---------QVKESLKLVQLQ
RDEYAE-HIKGERAQWQEKMR--KMSQ------------------EV-CTL---KKEKQ-
--------------------------------------------HDMHRVEELE-RSLSQ
L---------KHQ-MAEPLHLE----PPAVPSEV-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHLSLLNQAQK------ERLQRQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------KQEERI---------QQLA
EPQSGVEEL--------------------------------NNENKSALHLEQQVEELQE
KLREV--------ETVTSTQ----------------------------------------
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---------------------------------------------------------KEP
EAAVP----------APGTG-----GESVSEETPWALQEVMEKLEVGESWNSGLMDLLEE
KADLRERVEKL----------------------------------ELRFVQYWR--ERCH
Q-KINHLITEPEGSAKEAALGGGHHQAG----PRRR-DKG-A--A-GAAGDAAAS-CAH-
RNKGHSKFLAAAQNP-ANEP-GP-----EAPPPQE-L-----------------------
GAADQH-------GDLYE---VSL--TDSAQPAQ-------GEARK--GSPQDNPTAQ-P
IMQDH---------QEHPG-LGSNRSVPFFCWAWLRRRRR--------------------
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---------------------------------MWPQPCLPP----HPT-----MLEETR
QS----KLAA------------------------------------LKEY----------
QQRNS----PGVP-----AGVKMKK-------KNT--GSIPETA-----------TSGGC
HSPGDSRYQE-------L------------------------------------------
--------------------ELALD-------SSSAI-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEEKKTN---------SE--IHKAQME-QLE------AINILTLE
KTDLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGCLQYSLQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCSEAVLQWR--------LQQTIKE-RALLNAHMT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMW--KMLV------------------EA-RTL---KKEKK-
--------------------------------------------RDIHRIQELK-RSLSE
L---------KNQ-MGK-MGLQ----LPAVTSVV-------------EQLQD---EAKHL
RQEVESLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQDERL
----------------REQEEWRVQEQERLCEQNERLREQQKTLREQGERLRKQEQR---
----LCKQEERLQKQEKRLWDQEESLWEKEERL-------QKQEERLMLSQNHKLDKQLA
EPQCGFEDL--------------------------------NNEKKSALQLEQQVKELQE
RLGE----KET-------------------------------------------------
------------------------------------------------------------
-----------------------EPAASHQN-QQLETQLSLV--ALPGEGDGGEH-----
------------------------LDSEEEEAPQST-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSGFMDLPKE
KVGGKEQVEKL---------ELGFIQLSGATDGMREYITEYESQGAVPNTR---------
-----------------------HQEKEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
DHEAHGKFLTAAQNP-TDEP-AP-----GAPAPQELGA----------------------
--ADEQ--------DFYE---VSL--DDSEEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLS---PVMQDT----------------------------------------------
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---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NDDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLESVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-AHEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
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---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----LGVP-----AGAKKKK-K-----IKN--GDSPERP-----------TASDC
QSPENIQDIL--KVLVSDLNRSNGVSLPPLDKRKMPTDHTAPVLP-------TTATDTMF
L--RVAPSPDAD---LT----------QSHDAGNCSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGSL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRVRQVDSLAISSFLVDSEPK
ELCCMVGKS--NEDLRQQNSELEEKLRVLVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSETAGGNEQ--------LQHA-MEERAQLETHVG---------QLMESLKQLQVE
RDQYAE-NLKGESAMWQQRVQ--QMGE------------------QV-HTL---KEEKE-
--------------------------------------------HRERQVQELE------
--SSL--AALRSQ-MEEPPPPE----PPAGPSEA------------EERLQG---EVEQL
QKELERLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEGRL
LELEREAQRWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELARKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
LHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
ELARQELQE----------AQERLKATSQEN-QQLQAQLSLV--ALPGEGDVDQEE----
---------------------------QDEEVPQSS-LTIPED----------------L
DSREAMVAFFNA--AIARAEEEQA--------RLRVQLREQKARCRSLSH-LAAPVQSKL
EKEAV----------VPRNV-----GDSASEESSQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNEWQGKFLAISQNP-GDML-TP-----VPTGSQEFGAA-DQ------------------
------------QGDLRE---VSL--ADDIEPAQ-------GEAGV--PAAHENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
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-----------------------------------------M----LPV-----DGEERK
LE----GL-----------------------D-------------T---EGPTSSATLKD
LEVRGSGRRCSGP-----AGQPSNL-L-----PQWGLGAPLPAE-----------TAHTH
PNPND--CSL-YFLTHSSSTSSL---------------------------------LHAP
-------------QNPCQEPAVVLD-------LRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-KRELEVQIQRLNIQ---
KEKLN--------TDLYY------MKRSLRYFE---------------------------
-----YESKDVAGCLQHSLQHIAELEWALSAVTATQEKKE--------------------
----------------------------------------------------------IS
--TSSRGKAVIEWQ--------LEQSIRE-Q------------------LKELVKQVQLE
RDEYAQ-HIKGERAWWQQRMR--KMSPEGSSD------------PSV-CTL---KKEKK-
--------------------------------------------HDTHGVEKLE-RSLSK
LKNQRG----------KM--GL-P---PAVPSKV-------------E--------LQHL
RKEVERMAGELQAQ-------------VDNN--QRMSVLIWGQK------ERLQEQ----
------------------------------------------------------------
-------------------------------------------EERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEQQVKELQE
KLS---------------------------------------------------------
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--------------------EVKETVTSTPY--PRRE-----------------------
-----------------------------PEAVIPV-PV---------------------
-TGAESMRLT--------------------------------------------------
-------------------------------------------------------DLLEE
KADLREWVEKL----------------------------------ELRFIQYWK--DRRH
Q-KVHHLIMEPGGSAKDAALGGGLHQAG----PGQGGDESEA--A-GAAG-DNDVACGD-
YNKGHSKFPATAQNP-ADEP-SL-----GAPAPQELGAADKH------------------
-------------GDLCE---VNL--TDS-------------------------------
--------------VEHPG-LGINPCVPFFCRAWLPRRRR--------------------
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-------EAVLQRQ--------LQQTRKE-RVLLNAHVR---------QVTESFKQVQLE
RDEYAQ-HIKGERARWQERMQ--KMSV------------------EA-NTL---KEEKM-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KHQ-IG-PHCLL----PFSAEKEL-------------EQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALNLLSKEQK------ERLQEQEERL
QEQEE-RRL---------------QEQESLCEQKERLR-------EQGERLRKQEERLQK
QEER----------------------------LRKQEGRLRKQEERLALSQNHKLDKQLA
EPQCGFEDL--------------------------------NNENKSALQLEQQVKELQE
KLSE----VKE-------------------------------------------------
------------------------------------------------------------
------------------------TVTSAPSKKGWEAGTSLW-----GGEVPGQR-----
------------------------SSSWREGNPSPL-QSHSRD----------------V
---TP-------------------------------------------------------
--------------------------------------------------LFCFMDLSK-
KADRKEQVEKL---------ELGFIQLSGATEGMREYITEYESQGAVPNTR---------
-----------------------HQEKEDVIRPA-QNEEMKV--K-LLELQELVLPLVS-
DHEGHDKFPSAAQNP-ADEP-AP-----GAPAPQELGA----------------------
--AEEQ-------GDLRE---VSL--ADSVEPAP-------GEARE--GSPRGNPTAQ-K
IVQLL---PVMQGT----------------------------------------------
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---------------------------------MWPQPYLPP----HPM-----MLEESR
QN----KLAA--------------------------------AKKKLKEY----------
QQRKS----PGIP-----AGAKTKK-------KKT--DSSPETT-----------TSGGG
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKTN---------NE--IHKAQME-RLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCREAVLHRR--------LQQTIKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KNQ-MAKPPSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEEML
----------------REQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRK
QEERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLALSQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSALQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQLSLV--ALPGEGDGGQH-----
------------------------LDSEEEEAPRPT-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTR---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
NHEGHGKFLIAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTVQ-Q
IVQLS---PVMQDT----------------------------------------------
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---------------------------MSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GSSPETT-----------TAGGC
HSPEDIQDIL--KVLVSDLNHSNGVALPPLDKWKVPKDHTAPAPP-------AA-DDSVS
L--GRVPSPGPT---LP-----SLESPQNHDANIGPNIMDETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLSSSANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTLDQ------LEKEKKAC---------QEKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKA---------------------------
-----GESEGLAGRLQSSRQRVGELERTLSAVSTQQKKADRHNKELTKERDA------LR
LELYKNNIN--NEDLKQQNSELEEKLRVVLA--EKAAMQLGAEEL--QKKLEMSELLLQQ
F-SSRSEAPDSNQQ--------LQQA-VEERAQLEKHVG---------QLMESLKQLQVE
RDHYAE-NLKGESAMWQQRMQ--QMSE------------------QL-RTL---KEEKE-
--------------------------------------------QSESRVQELE------
--TNL--AELRSQ-MVEPPPVE----PPAGPSEA------------EQQLQA---DVEQL
QKELENLAGKLHAQ-------------VQDN--NSLSRLNRE-------------QEERL
LELEHAAELWGEQAEERKQILESM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKETVELKSQEAQGLQQQRDQYLSH---LQ----QYVAAYQQHVAAYQQLTSEKEA
LHKQVLLQTQLMDRLQHEEVQGKMA----------------------------------V
EMARQELQE----------TQERLEATSQQN-QQLQAQLSLL--ALPGEEDEMDKE----
--------------------------EKEEEASRPS-LTIPED----------------L
DSREAMVVFFNA--ALASAEEEKA--------QLRRQLREQQTRCRRLAH-LEATSQSEP
TEQAL----------VPRSG-----DNCVSGESTQALQMAMEKL------QSRFLEVMQE
KVELKERVEELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWQGKFLAAAQSP-AETT-TP-----EPASPQEFGAT-DK------------------
------------QGDLRE---VSL--ADSVEPAQ-------GEAGA--ASPPENHTAQ-Q
IIQLL---REIQNPQERLG-LGTNPCVPFFYRADDNDEVKIMVI----------------
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---------------------------------MWP----PL------------------
--------------------PPPR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKR-K-----IKN--GSSPETT-----------TSGDC
PSPEDIQDIL--EVLVSDLNRSNGVAIPPLDKWKAPKDRAAPVTP--------SADDTVS
P--GGVPSPSASPPRVT-----SMASTQNHDANNGSGPIDESTSFSSTESLRQL--SQQL
NGLVSESSSYINGEGLASPANIKNLE----------------------------------
---------------------------SRYQELSVALDSSNLK--NKQLSSKIEELK--Q
ENQETLDQ------LEKEKKEF---------EQKLAKEQGAL-REQLQVHIQTIGILVSE
KTELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDA------LK
LELYKNNKN--NEDLKQQNSELEEKLRLLAI--EKSAMQLGMEDL--QKKLEMSELLLQQ
F-SSQ-PAPDSSQQ--------LQQA-LEERAQLETHVE---------QLKDSLKQLQAE
RDQYVT-NLKEESAMWQQKMQ--QVLD------------------QM-SKL---KEEKE-
--------------------------------------------RSVCQAQELE------
--TSL--AELRNQ-IAAPPP----QEPPAGPSEA------------EQWLQA---ETERL
QKELESLAGQLQSQ-------------VKDN--ESLSHLNQE-------------QEQRL
LELEREAECWGEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLSNE---NMEITSALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKETVEVKRQEVQDLQQQRDEYLNH---LQ----HYVAACQLHVAAYQQLALEKEA
LHKQVLLQTQLMDRLQHEEVQGKVA----------------------------------M
EVARQELQE----------TQERLEAANQQN-QQLQAQLTIM--AVPGEGDGLDSEE---
---------------------------QDEEAPRPK-LSVPEE----------------L
ESREALVEFFHS--ALASAEDEQA--------RLRGQLKEQKLRCQRLCH-LAAAAQDGV
EKEAPAPR----------TG-----GDSVPAEAHQALQVAMDKL------QGRFTELMQE
KVDLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLCLVGE
RNEWYGKFLA-AQKA-AGEP-TT-----APHTCQEPSTADNE------------------
-------------GGLQE---VSL--ADNVEPPQ-------GT-LQGQT-TPENPTAQ-Q
IMQLL---REIQNPQEHPG-LGSNPCIPFFYRADDNDEVKIMVI----------------
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------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNR----PRVP-----AGVNRNR-K------TN--GSIPETA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------STSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NERQKA-ERELEVQIQTLIIQ---
KEELN--------TDLYH------MERSLRYFE---------------------------
-----EESKDLAVRLQHSLQCKGELERALSAVIATEKKKAN-------------------
-----------------------------------------------------------Q
--LSSCSKAHTEWE--------LEQSLQD-QALLKAQLT---------QLKESFQQLQLE
RDECAE-HIEGERARWHQRMS--KMLQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEELE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQSQ-------------VKNN--QHISLLNRRQE------ERIREQEERL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------RQLA
KPQSVFEEL--------------------------------NNENKSTLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLNLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPQPM-PSVPED----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELVKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VTL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPLFCWAWLPRRRR--------------------
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---------------------------------MWPHPFPP-------------------
----------------------PC-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PGGP-----AVVKKKK-K-----LKN--GSNPETS-----------TAGDD
HSPEDIQDIL--KVLVSDLNRSNGVALPSLDRWQAPKDHAASAPP-------SAAYDTVS
P--GGVPSSGTT---LT-----S-----NYDADSEPNVMDETKTFSSTESLRQL--SQQL
NGLLSESTSYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQES---------QQKLAKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLAGRLKSSRQRVGELEKTLSAVSTQQKQVEKYNKELTEERDT------LR
LELFKNNKS--NEDLKQHNSELEERLRVLTA--ENAASQLGVDEL--QKKLEMSELLLQQ
F-SSGSASTDGDQQ--------FQQA-LEDRARLETQVA---------QLTESLRQLQLE
REQYTE-NRKEERSMWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------RSVSQIRELE------
--SSV--AELRSQ-LVEPPGPE----PPAGPSEE------------EQRLQA---EAKQL
QKEVERLTGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRRILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NVEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTDMMDLKNQEVQGLQQQREQLLSQ---LQ----QYAAAW-------QQVASEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELQE----------TQERLEATTQQN-QQLQAQLSLL--ALPHGGTEVDQEDK--
--------------------------EEEEEAPLPD-VTIPED----------------L
DSREAMVAFCNA--ALASAREEQV--------RMLGQLREQRAQCRRLVH-LAVASQSEP
EKVAL----------APGSG-----GDSVPVESHQALQVAMEKL------QSRFLEVMRE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWHGRFLAAARSP-AEEP-PP-----GTKDAHELGAAMAE------------------
------------QGDLRE---VSL--ADSAEPAQ-------GATGL--DSAPENPTAR-Q
IMQLL---REIQNPEERPG-LGSNPCIPFFYRADKNDEVKIMVI----------------
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-----------------------------MGVGLPAWVDKALLSPTPPL------SQTCK
S---------------------------------NPW-----------------------
--------------------GSRREEAPGCEASGWTLALSGSEFLGKSVVLELRIHSSAL
RH----CLWK--------------------------------PWDKLKEY----------
QQRSS----PGVP-----AGAKTKK-------KTT--GSSPETT-----------TSGGC
HSPGDSRYQE-------L------------------------------------------
--------------------ELALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKEQVEHQ------LEEEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQSSLQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------FRQTLKE-RALLNAHVT---------QVTESLKQVQLQ
RDEYAQ-HIKGERARWQERMR--KMSV------------------EA-RTL---KEEKM-
--------------------------------------------RDTYRIQELE-RTLSE
L---------KHQ-IAEPSSSA----PPAGPSEV-------------EQLQD---EAKHL
RKEVESLVEKLQFQ-------------VENN--QALSLLSKEQK------ERLQEQEERL
REQEE-RRLWEQNERLREQEEWTLQEQESLREQKERLR-------DQGERLRKQE-----
---------ERLRKQEERLQKQEERLQKQEERLRKQEERLRKQEERLTLSQNHKLDKQLA
EPQCGFEDL--------------------------------NNEDKSALQLEQRVKELQE
KLSE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQWN-QQLEAHLSLM--ALPGEGDEGGH-----
------------------------RDSEEEEAPRPM-PHIPED----------------L
ECQEA-------------------------------------------------------
--------------------------------------------------MSSFMDLPKE
KADRKEQVERL---------ELGFIQLSGATEGMRDYISEYESQGAVPNTR---------
-----------------------HQEKEDVMGLA-QNEEMKV--K-LLELQKLVLPLVC-
NHEGHDKFPPAAQNR-GDEP-AP-----GAPAPQELGA----------------------
--AEEQ-------GDLCE---DTQ--EHPGLASK-----------P--CVPFFYRAAENR
EINIV---II--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETA-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNAATLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESATCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELEGLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAVTQQN-QQLRAQLSLM--AHPGEGDGLDREEEED
---------------------EE--EEEAVAVPQPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAAP----------APGTG-----DDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQDP-ADEP-AS-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGSVEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSEKT---RQNKLAEAKKKFTDY----------
RQWNI----AGV--GTRATDTKK-K-K-----INN--GTNPETT-----------TSGGC
HSPEDKQQNRAQLKEEKKASHQHQE-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-RREIEAQDHTIRILTCQ
KTELE--------TALYY------SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVS
TSLIPGESKDLAGHLHHSWHFAGELLRALSAVSTRHKKADRYIEELTKERDA------LS
LELYRNIIT--NEELKKKNAELQEKLRLAES--EKSEIQLNVKEL--KRKLERDKILLPQ
V-QTNTLQEE--------------------------------------------------
--------------TWRQ-----E-------------------------------EELRE
QEKK--------------------------------------------------------
------------------------------------------------------------
--------------------IRKQEEK---------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MW-----RQEE---------RLREQEE
---------RLREQE----------------------ERLREQEEK--------------
-----------------------------------------MREKE--------------
-------ER-------------------------IREQKEKM--Q--------------E
---------------------------------------RLPEHEERCSEPCL--PPSK-
VLCN--------------------------------------------------------
---MS----------HTGSVEPAGGEA---------------------------------
----------------------------------------------GEGS-PQDN-PSAQ
E-----I-------------------MQLF--------------C-GM------------
------------------------------------------------------------
------------------------------------------------------------
-----------KNAQQRPG-LGSNSCTPFFYRGDKKKM-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SRYQE-------L------------------------------------------
--------------------EVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEEKKAN---------NE--IHKTQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARYFE---------------------------
-----EESKDLAGRLQSSLQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
-------------------------------------------------VTESLKQVQLQ
RDEYAQ-HIKGERARWQERMR--KMSV------------------EA-RML---KEEKK-
--------------------------------------------HDIHRIQELE-RSLSE
L---------KPQ-IAEPSSPA----PAAGPSEV-------------EQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------ERLQEQEERL
QEQEE-RRLQEQ---------------EGLCEQKERLQ-------EQGERLRKQEERLRK
QEERLRKEEERLQKQEKRLWEKEERLR-------MQEERLRMQEERLALSQNQKLDKRLA
EPQCSFKDL--------------------------------EH-----------------
----------L-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QHLEAQLSLM--ALPGEGDEGGH-----
------------------------LDGEEEEVPQLM-PSIPKD----------------Q
ESQEA-------------------------------------------------------
--------------------------------------------------MSSFMDLPKE
KADRKEQVEKL---------ELGFIQLSGAREGMREY-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAALLLM-PSILEE----------------L
ESREAMVAFLNS--AVASAEEEQA--------WPRGQLKEQRVSCHCLAH-LVASVQKEP
EAAAL----------VPGTG-----GDSVCWEAHRALQGAMEKL------QSHFMELMQE
KVDLKEQMEKLEGRC---------IQLSGETDIIRKYITLYQMLKT------WHQKEYIS
S-------------------------------LAQDKEEMKVKLLELLELQELVLRLVGN
HNKWHGKFLAAAKNP-VDEP-AP-----GAP----LGAA-NK------------------
------------QGDLCK---MSL--VHSVEPAQ-------EEARE--GSPHDNPTAQ-Q
IMQLL---PEMQNPQEHPD-LGSNPCIPFFYHV------KITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MKV--K-LLELQEPVLLLMG-
HHEGHDKFLPTAQNS-AEEP-AP-----GAPAPQELGA----------------------
--AEEQ-------GDLCE---VSL--ADSVEPAA-------GEARE--GSPCGNPTAE-K
IVQLL---PVMQDTQEHPG-LASKPCVPFFYRAAENREIKIVII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FKEY----------
WQRNS----PGGP-----AG-AKNR-------ETN--GSVTETA-----------TSGGC
HSPGD--SAT-GIDGEGPTSSAP---------------------------------LKDL
-------------ESLCQELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKKTIKSLK--Q
QKKHVEHQ------LEEEKKAN--------------IEKQKT-ERELEVQIQRLNMQ---
KGKLS--------PDLYH------TKRSLRYFE---------------------------
-----EESKDLVSCLQRSLQHTGELEQALSAVTATQKKKAN-------------------
-----------------------------------------------------------Q
--FSSRSQALTEWQ--------LEQSIQE-KARLRERLT---------RMRESLKQAQLE
RDEYAQ-HLKGERARWQQRMR--KMWQEPPAPSPSLQGPLSLCFGQV-CML---KKEKK-
--------------------------------------------HDMRRIENLE-RRLST
L---------KNQ-MAEPLPPE----PPAVPSEV-------------E--------LQHL
RKELERVSAELQVQ-------------VENN--QRVSLLNRGQK------ERLR------
------------------------------------------------------------
-----------------------------------------EQEERL---------QQLA
EPQSDFEEL--------------------------------NNENKSALQLEQQVKEWQE
KLDKV-------RETVTSAP-SK-KGGEAGTSLWGGVCQAR-D-----SSSLGA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------G-----D------------------------TSHFMDHLEE
KVNL--------------------------------------------REQYWR--ERCH
Q-----------GSAKDAAMGRGHHQAG----PGQGGDEGEA--A-GAAGDAVTA-CGD-
YNKENHKFLATSQNP-ADEP-GP-----GAPVPQEL------------------------
GAAYKAC-------WRCT---QIP--TS-NSPKI-----------------FERPGRV-L
PTTTILHSQSAQEHQEHPG-LGSNRSVPFFCWAWLQRRKR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----AGAKKKK-K-----IKN--GSSPETT-----------NSGDC
HSSEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNAASLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMVAPQNHDADNVPNLMDEAKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNVTIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QVSE------------------QV-HTL---REEKE-
--------------------------------------------HNMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---ETEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KK-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVAAYQQLTSEKEA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
DMASQELQE----------TQERLEAVSQHN-QQLRAQLSLI--ALPGEGDGLDREDEE-
----------------------------EEEVPWPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------KLRGQLKEQRVRCRRLAH-LLASAQ-EP
EAAAP----------PPGTG-----GDSVCGETHRALQEAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVND
RNEWHSRFLAASQNP-AAEP-SP-----EAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGS-EPAQ-------GETGE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----KLAA-------------------AKR-------------KLKEY----------
WQRNS----PGVP-----AGAKRNR-K------TN--GSIHETA-----------TSGGC
HSPGD--SAT-GIHGESPTSSAT---------------------------------LKDL
-------------ESPCQELAVVPD-------SRSVK-------------VSQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVVHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNIQ---
KGKLN--------TDLYH------TKRSLRYFE---------------------------
-----EESKDLAVRLQHSLQRKGELERALSAVTATQKKKAE-------------------
-----------------------------------------------------------R
--FSSRSKARTEWK--------LEQSMRE-QALLKAQLT---------QLKESLKEVQLE
RDEYAE-HLKGERARWQQRMR--KMSQ------------------EV-CSL---KKEKK-
--------------------------------------------HDKYRVETLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEA-------------E--------LQHL
RKELERVAGALQAQ-------------VEYN--QRISLLNEGQK------ERLRE-----
--QQE-R--------------------------------------------------LP-
-----------------------------------------EQEERL---------QQLA
EPQNSFKEL--------------------------------NNENKSVLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------KERLEAASQQK-QQLTAQLSLM--ALPGEGDGGGH-----
------------------------LDSEGEEAPRPI-PSIPQD----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEDEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGNNCCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MA---EET-------------------
--GQSK--------------------------LAAAKKK-------FKEY----------
WQRNR----PGVP-----AAAKRNT-------KAN--GSSPETA-----------ASGGC
HSSEA-----------SSSASSS---------------------------------LHAR
-------------QSPCQEQAAVLN-------SRSIK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNDTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEGQIQRLNTE---
KKKLN--------TDLYH------MKHSLRYFE---------------------------
-----EESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPD-------------------
-----------------------------------------------------------G
--FSSRSKALLKRQ--------LEQSIRE-QILLKGHVT---------QLKESLKEVQLE
RDQYAE-QIKGERAQWQQRMR--KMSQ------------------EV-CTL---KEEKK-
--------------------------------------------HDTHRVEELE-RSLSR
L---------KNQ-MAEPLPPD----APAVSSEV-------------E--------LQDL
RKELERVAGELQAQ-------------VENN--QCISLLNRGQK------ERLREQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------EREKRL---------QQLA
EPQSDLEEL--------------------------------KHENKSALQLEQQVKELQE
KLGQV-------METLTSAE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------ASGTG-----GES-----------------S------GLMDLLEE
KADLREHVEKL----------------------------------ELGFIQYRR--ERCH
Q-KVHRLLTEPGDSAKDASPGGGHHQAG----PGQGGEEGEA--A-GAAGDGVAA-CGS-
YSEGHGKFLAAARNP-AAEP-SP-----GAPAPQEL------------------------
GAADKH-------GDLCE---ASL--TNSVEPAQ-------GEARE--GSSQDNPTAQ-P
VVQLLG---EMQDHQEHPG-LGSNCCVPCFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----KLAL-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----AGVNKNR-------KTN--GSSPETA-----------TSGGC
HSTG--DSAT-GIDGEGPTSSAP---------------------------------LKDL
-------------ESPSQELAAVLD-------SRPVK-------------ISL-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
EKKQVEHQ------LEEEKKAN--------------NEKQKA-ERKLEVQVQRLNIQ---
KGKLS--------TDLYH------MKRSLRYLE---------------------------
-----EESKDLAGCLQHSLQHEGELERALSAITATQKKD---------------------
-----------------------------------------------------------R
--SSSHRKAHMEWK--------LEWSIRE-QALLKAQLT---------QMKDSLKQVQLE
RDEYAQ-HLKGERARWQERMR--KMSQ------------------GV-CTL---KKEKK-
--------------------------------------------DVMHWVEKLE-RSLSK
L---------KNQ-TAEPLPLE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHVSLLNQAQK------ERLQEQEEK-
---------------------------------------------------------LR-
-----------------------------------------EQEERL---------QQLA
EPQSGVEEL--------------------------------NNENKSALQLEQQVEELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------KEHLEAASQQN-QQLTAQLRLM--GLPDEGDGGGH-----
------------------------LDSEEEEAPQPL-LSVPED----------------L
ESWEAMSGLMDI--LE---------------------------------------E-K--
------------------------------------------------------------
-ADLSELVKKQ----------------------------------ELRFIQYWG--ERCH
Q-NVRQLIIEAGGSAKDAAMGGGHHQAG----PAQGGDEGES--A-GAAGDAVTA-CRE-
YN-KHSKFLAAAQNP-ANEP-SP-----GAPAP-QEL-----------------------
VAADQH-------GDLCE---VSL--TDSTQPAQ-------GEARE--GSPQDNPTAQ-P
IAQD---------HQEHPG-LGSNHCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLP----PHPA-----MLEETR
ER----KLAA--------------------------------AKKKLKEY----------
QQRSS----PGVP-----AGAKTKK-------KTT--GSSPETT-----------TSGGC
HSPGDSRYQE-------L------------------------------------------
--------------------ELALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKEQVEHQ------LEEEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLASRLQSSLQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------FRQTLKE-RALLNAHVT---------QVTESLKQVQLQ
RDEYAQ-HIKGERARWQERMR--KMSV------------------EA-RTL---KEEKM-
--------------------------------------------RDTYRIQELE-RTLSE
L---------KHQ-IAEPSSSA----PPAGPSEV-------------EQLQD---EAKHL
RKEVESLVEKLQFQ-------------VENN--QALSLLSKEQK------ERLQEQEERL
REQEE-RRLWEQNERLREQEEWTLQEQESLREQKERLR-------DQGERLRKQE-----
---------ERLRKQEERLQKQEERLQKQEERLRKQEERLRKQEERLTLSQNHKLDKQLA
EPQCGFEDL--------------------------------NNEDKSALQLEQRVKELQE
KLSE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQWN-QQLEAHLSLM--ALPGEGDEGGH-----
------------------------RDSEEEEAPRPM-PHIPED----------------L
ECQEA-------------------------------------------------------
--------------------------------------------------MSSFMDLPKE
KADRKEQVERL---------ELGFIQLSGATEGMS---DEYESQGAVPNTR---------
-----------------------HQEKEDVMGLA-QN-EMKV--K-LLELQKLVLPLVC-
NHEGHDKFPPAAQNR-GDEP-AP-----GAPAPQELGA----------------------
--AEEQ-------GDLCE---VSL--ADSVEPAA-------GEARE--GSPRGNPTAE-K
IVQLL---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MLPVDGEE-----RKS-----EGSDTE
GDRTSPCG--------PT-----SSATLKDLEVGGSGRRCSDPAGQPSNL----------
LPQRG----LGAP-----LPAE-----------TA--HTQP-SP-----------NDRSL
YLSPK-----------SSSASSS---------------------------------LHAP
-------------QSPCQEQAAVLD-------SRSIK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNDTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEGQIQRLNRE---
KKKLN--------TDLYH------MKHSLRYFE---------------------------
-----EESKDLAGRLQRSPDRNFSL----F---------TI-------------------
-----------------------------------------------------------Q
--FSSCSKALLKRQ--------LEQSIRE-QILLKGHVT---------QLKESLKEVQLE
RDQYAE-QIKGERAQWQQRMR--KMSQ------------------EV-CTL---KEEKK-
--------------------------------------------HDTHRVEELE-RSLSR
L---------KNQ-MA--LPPD----APAVSL-S-------------G--------AEDL
RRSWRVVAGELQAQ-------------VENN--QCISLLNLR------------EQEERL
HGERR-G--------------------------------------------------LG-
------------------------------------------NRKEL---------QQLA
EATERLEG---------------------------------KNENK-----SQQVKELQE
KPQV--------TETS-LGR----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------EEP
EAAVQ----------LRT-G----------------------------------------
-A-------------------------------------------SLPSACRSH--GKLE
G-KVHRLLTEPGDSAKDAAPRGGHHQAG----PGRGGEEGDA--A-GAAGDGVAA-CGN-
YSEGHGKFLAAARNP-AAEP-SP-----GAPAPQEL------------------------
GAANER-------GDLCE---VSL--TNSVEPAQ-------GEARE--GSSQDKPTAQ-P
IVQLLG---EMQNHQEHPG-LGSNCCVPCFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSIPEKA-----------TSGGC
QPPRD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------SRSVE-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRVLEVQIQTLNIQ---
KEELN--------TDLYH------MKRSLRYFE---------------------------
-----EKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKAN-------------------
-----------------------------------------------------------Q
--LSSRSKARTEWK--------LEQSMRE-ETLLKVQLT---------QLKESFQQVQLE
RDEYSE-HLKGERARWQQRMR--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEELE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKKN--QRISLLNQRQE------ERIQEQEERL
RKQEE-R--------------------------------------------------IQ-
-----------------------------------------EQHKSL---------QQLA
KPQSVFEEP--------------------------------NNENKNALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPQPM-PSVPED----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELVKK-----------------------------------ELCFIHHWR--DRRH
Q-KTHHLLSEPGGCAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFLCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-QKNS----PSGP-----AVVKKKK-K-----LKN--DGSPETS-----------TARDD
HSPEEIQDIL--KVLVSDLNRSNGVALPSLDRWQAPRDHAAPVPP-------SAAAATVS
P--GGVPSPGTT---LT-----SVASLQVC-----------ALTFSSTESLRQL--SQQL
NGLLSESTSYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQES---------QQKLAKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLAGRLKSSRQRVGELEKTLSAVSTQQKQVEKKALRMDLRVKA------LA
QSVH-------------HR-------RALLQ--ELWGEHPGFPEL--N-----FSFFSVQ
F-SSGSASPDSDQQ--------FQQA-LEDRARLETHVG---------QLTESLKQLQLE
RDQYTE-NLKEERAMWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------RSVSQVQELE------
--SSL--ADLRSQ-MAESPAPE----PPAGPSEE------------EQRLQA---EASRL
QEELGRLTGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NVEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMDLKNQEAQALQQQREQLLSQ---LQ----QYAAAW-------QQVASEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELRE----------TQERLEATTQQN-QQLQAQLSLL--APPGEGAEEDEEDE--
----------------------------EEEAPLPD-VTIPED----------------I
DSQEAMVAFCNA--ALARAREEQV--------RLLAQLREQRAQCRRLAH-LATTSHGEP
EKPAL----------APGSA-----GDSVSAESHGALQLAMEKL------QSRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWQGRFLAAARSP-AEEP-TL-----GPKDAQEVGAAAAE------------------
------------QGDLLE---VSL--ADSVEPAH-------EAAGL--GPAPENPTAR-Q
IMQLL---REIQNPEERLG-LGSNPCIPFFYRADKNDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KK-
--------------------------------------------RDIHRIQELK-RSFSE
L---------KNQ-MAEPLSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEEKLQSQ-------------VENN--QALSVLSKEQK------QRLQEQEEML
----------------REQEAQRVRELERLCEQNERLREQQKTLQEQGERLRKQEQRLHT
QEE-------RLQKQEKRLWDQEERLWKKEERL-------QKQEERLVPFQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSTLQLEQQVKELQE
KLDE----EP--------------------------------------------------
------------------------------------------------------------
-------------------------AASHQN-QQLETQLSLV--ALPGEGDGGEH-----
------------------------LDSEEEEAPRST-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTW---------
-----------------------HQEMEDVIRLAQKEEEMKV--N-LLELQELVLPLVG-
NHEGHGKFLTAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMSEKT---QQRKLAGTKRKFTDY----------
HQWNS----AGV--GTGATDTKK-K-K-----INN--GTNPETT-----------TSGGC
RSPEDKQQNRAQLKEEKKASHQHRQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-RRQLEAQDHTIRILKCQ
KTELE--------TALHY------SQDAARKFEE--------------------------
------DSKDLAGRLHHSWHFAGELQRALSAMSAEHKRADRYIKELTKEREA------LS
LELHRNIIT--NEELKEKNAELQEKLRLVET--EKSETQLHIKEL--KRKLETDKILLPQ
V-QTNTLQE---------------------------------------------------
-------------KMWRQEEKLR---------------------------D---QEKLRK
HEEKMWRQEQRLRDQEKELREQEQR-------MRKQ------------------------
--------------------------------------------------------EQQM
RKQEEQMRKQEQQMRKQEEQMGEQEEQMRKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EK---QMLKQKKQ----------ML-----KHKE---------QMGKQEE
QMG--EQEEQMWKQEKQM-LKQKEQMRKQ-------EEQMAEQEEQMQKQEEQMQ-----
------------------------------------KQEEQVRKQEEQMR---K---QEE
QMWKQEEQ----MRKQEKQMGEQKEQMRKRE-EQMRKREEQ---------VRKREEQVRK
REEQMRKRE-------EQMRKREEQMRKQEEQMGEQ-EEQMRMQVERLRFKEERLWVEYE
KMQEEEEKVWGQVEKMWEK---------------KERMGEQEEKMQEERCSEPCLPPSKY
PRDMS----------HAGSLKPAREAG---------------------------------
----------------------------------------------KG--YSHDN-RTAQ
Q-----I-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-TQLP---PGMKNAQERPG-LGSTSCIPFFYRGDKKKI-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQVPTCTPDP-CVSIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREEE--
--------------------------EEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-ANEP-DP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNR----PRVP-----AGVNRNR-K------TN--GSIPETA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------STSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NERQKA-ERELEVQIQTLIIQ---
KEELN--------TDLYH------MERSLRYFE---------------------------
-----EESKDLAVRLQHSLQCKGELESALSAVIATEKKKAN-------------------
-----------------------------------------------------------Q
--LSSCSKAHTEWE--------LEQSLQD-QALLKAQLT---------QLKESFQQLQLE
RDECAE-HIEGERARWHQRMS--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEELE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQSQ-------------VKNN--QHISLLNRRQE------ERIREQEERL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------RQLA
KPQSVFEEL--------------------------------NNENKSTLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPRPM-PSVPED----------------P
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELVKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VTL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPLFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPSPYPPS------------------
--------------------SPPP-PAMSEET---RRSKLAAAKKKLKEY----------
QQKHS----PGVP-----AGAKKKK-K-----VKN--GTSPDTT------------SGGC
HPPED-----------------------------APKDCAAPTQP-------A--DDPMP
P--DGVPSSGAG---AT-----STVTPQNHD-DNCPHLMDETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGPASSANMKDLE----------------------------------
---------------------------SRYQELAIALDTSYAT--NNQLNKTIEELK--Q
EKQEILDQ------LEKEKRDC---------HQKLVKEQGSL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQVVDHKA---------------------------
-----GEAKELAGRLQSCRQRIGELERTLSAVSTQQKQAEEHNKELTKERDA------LK
LELYRNTKS--NEDLLQQKSELEEKLRVLLT--QKAAMQLEVEDL--QKKQEMTELLLQQ
F-SSACDSSDSNMK--------LQRA-MEERAQLETHVG---------QLMESRTQLQLE
RDKYAD-ELIKETAMWQEKIK--KMSD------------------QV-VVL---QEEKE-
--------------------------------------------RCLRQMQELE------
--NNL--FQHRTQ-TAEPPCPE----PPAGPSEV------------EQQLQA---ETDQL
RTELESLAGQLQAQ-------------VRDN--ESLSRLNQE-------------QEERL
LELERAAERWDEQEKQHRQVLETI------------------------------------
------------------------------------QSDRTTIS--RALSQNRLLKEQLA
ELQSGFIRMSNE---NMEITSALHSEQHI-----------KK-------ELAKKLGQLHE
NLGEMKETMDQKNQEAQSLQEQRDQYLTY---LQ----QYVAAY-------QQLVSEKEA
LHKEMLLHIQVIDQIKHESVVSKAE----------------------------------A
EMARQELQV----------AQERLQAADQQN-QELQAQLSST--ELPEEGYELSDEEV--
---------------------------KDDDPHQPI-LTIPAD----------------F
ETQEAMVAYVNM--ALASAEKERA--------QLREQLKKHRARFQRLVK-LTDLTRKAP
QEVTP----------APATR-----TEAVSEEEYQALQGAMENL------QSRFIEVMRE
KADLKERLEELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKGKLL---ELQELVLQLVKE
REKRHGKFLAAAQSP-AVET-TP-----GSAAPQELGAADVQ------------------
------------QADLCE---VSL--VDG-EPAQ-------EETEE--GSPPENLTAQ-Q
IIQLL---HEIQNPQERPG-LGNSPCIPFFYRADENDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAVLLLM-PSILEE----------------L
ESREAMVAFLNS--AVASAEEEQA--------WPRGQLKEQRVSCHCLAH-LVASVQKEP
EAAAL----------VPGTG-----GDSVCWEAHQALQGAMEKL------QSHFMELMQE
KVDLKEQMEKLEGRC---------IQLSGETDIIRKYITLYQMLKT------WHQKEYIS
S-------------------------------LAQDKEEMKVKLLELLELQELVLRLVGN
HNKWHGKFLAAAKNP-VDEP-AP-----GAP----LGAA-NK------------------
------------QGDLCK---MSL--VHSVEPAQ-------EEARE--GSPHDNPTAQ-Q
IMQLL---PEMQNPQEHPG-LGSNPCIPFFYHV------KITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WHRNS----PGGP-----AGAKKNR-------KTN--GSSPETA-----------TSGGS
HSPG--DSAT-GIDGEGPTSSAP---------------------------------LKDL
-------------ESPSQELAAVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNIIKSLE--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKT-ERELEVQIQRLNRQ---
IKKLN--------TDMNH------TKRSLRYFE---------------------------
-----EESKDLAGRLQQTLQCIEELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LEQSIQE-KARLKAQLT---------QMKDSLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTRRVEELK-RSLSK
L---------KNQ-MAKPLPPE----PPAVPAEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQPQK------ERLQEQEEKL
RKQEE-R--------------------------------------------------LR-
-----------------------------------------EQDEKL---------QQLA
EPQSGVEEL--------------------------------NNENKSALQLEQQVEELQE
KLE---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEASSQQS-QQLNAPLNLT--ALPGEGDG-GH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGFMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSAEDAAMGGGHHQAG----PAQGGDE-----G-GAAGDTIMA-CAD-
HNNEHSKLLTSSQNP-AHEP-RP-----GAPAP-QEL-----------------------
RAANQH-------GDLCE---LSL--SVSAETGQ-------GEARE--GSPHDNPTAQ-P
ITQE---------HQEHPG-LGSNRCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GHSPERP-----------TASDC
QSPEN-----------------------------VPTDHIAPAPP-------TAATDTMF
L--GVAPSPDAD---LT----------QVLLLEPGMGR-PRWGTFGM------M--GVEM
NLAYCVPVXXXXXXXXXX-XXXXXSE----------------------------------
---------------------------NRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGSL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDA------LK
LELYKNSKS--NEDLRQQNSELEEKLRVLVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSSAAGGNEQ--------LQHA-MEERAQLETHVS---------QLMESLKQLQVE
RDQYAE-NLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRERQVQELE------
--TSL--ATLRSQ-MEEPPPPE----PPAGPSEA------------EEQLQG---EVEQL
HKELERLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEGRL
LELEREAQRWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELARKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
IHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
ELARQELLE----------AQERLKATSQEN-QQLQAQLSLL--VLPGEGDVDQEE----
---------------------------EDEEVPQSS-LAIPED----------------L
DSREAMVAFFNA--AIARAEEEQA--------RLRVQLREQKARCRSLSH-LAAPVQSKL
EKEAV----------VPRNV-----GDSASEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-GDVL-TP-----VPTGSQEFGAA-DQ------------------
------------QDDLRE---VSL--ADDIEPAQ-------GEAGV--PAPHENPTAQ-Q
IMQLL---REIQNPRERTG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------FTDY----------
HHWNS----AGV--GTGATDTKK-K-K-----INN--GTNPETT-----------TSGGC
HSPED-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------YIKELTKEREA------LS
LELHRNIIT--NEELKEKNAELQEKLRLVET--EKSEIQLHIKEL--KRKLETDKILLPQ
V-QTNTLQE---------------------------------------------------
-------------KMWRQEEELR---------------------------D---QEKLRK
HEKKMWRQEQRLRNQEKELREQEQW-------MQKQ------------------------
--------------------------------------------------------EQQM
RKQEQQMRKQEEQMWKQEEQMRKLEEQMRKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EK------------------------------------------------
QMG--EQEEQMRKQEEQM-RKL--------------------------------------
------------------------------------------------------------
---------EEQMRKQEKQMGEQEEQMRKQE-----------------EQMRKLEEQMRK
REEQVRKRE-------EQVWKREEQMWEQEEQMGEQ-EKKMRKQVERLRFK-ERLWVEYE
KMQEEEEKVRGQVE----K---------------KERMGEQEEKMQEERCSEPCLPPSKY
PRDMS----------HADSLKPAREAG---------------------------------
----------------------------------------------KG--YSHDN-RTAQ
K-----I-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-TQLP---PGMKNTQERPG-LGSTSCIPFFYRGDKKKI-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSEET---RQSKLAAARKKLREY----------
QQRNS----PGVP-----AGAKKKR-K-----IKN--GSNPETA-----------TADGC
HTPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKAPKDRAAPAAP--------TVDDTVS
P--GGVPSPCASPPRVT-----SMASTQNHDAKNEPFLIEESKCLSSTESLRQL--SQQL
NGLVSESSSYINGEGLATSANIKDLE----------------------------------
---------------------------SRYQELSLALDSSNLT--NKQLSSKIEELK--Q
QHQETLDQ------LEKEKKEF---------EQKLMKEQGSL-REQLQVHIQTIGILVSE
KTDLH--------TALVH------TQQAVRQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSAVSTQQKQADKHNKDLTKERDA------LK
LELYKNNKD--NEDLKEHNSELEERLRVCMK--EKEALQLGVQEL--EKKLEMSELLLQQ
F-SSGSKPPDSNQQ--------LQQA-LEERARLETRVG---------QLKDTLKHMQLE
RDKYVE-NLKEDNAFWQERMK--QMSE------------------KM-QQL---KEEKE-
--------------------------------------------HSVSQVQELE------
--ASL--AELKKQ-IEVPPA----QEPPAGPSEV------------EERLQA---EAEQL
QKELENLAGQLRAQ-------------VQDN--EGLSRLNWE-------------QEQRL
LELERAAECWGEQAEERKQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQNGFVRLSNE---NMEITSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELKETVELKSQEAESLQQQRDQYVSH---LQ----QYVAAYQQHVAAFQQLASDKEM
LQKQVLLQTQLMDRLRHEEVQGKAE----------------------------------A
EMARQELQE----------TQGRLEAATQQN-QQLQAQLNLM--AMPEEGDGLDGEE---
---------------------------KDGEAAPPK-LSMPED----------------L
ESREALVAFCNS--ALASAEEEQA--------RLRGQLKEQRLRCKRLAR-LVAPGT---
-------------------T-----EDSVPGETHQALQVAMDKL------QSRFLELMQE
KVDLKERVEDLEHRC---------IQLSGETDTIGEYITLYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVDE
RNEWQGKFLATAQNP-AGEP-TT-----APP-AQELGAASGR------------------
------------GDDLRE---VSLADSDSAEPPQ-------GEALSRHT-GVENPTAQ-Q
IMQLL---CEIQNPRERPG-LGNNPCVPFFYRADENDEVKITVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
QS----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PGVP-----ARAKRNR-------KTN--GSVPETA-----------TSGGC
HLPG--DSAT-GIGREGPTSSVP---------------------------------LKDL
-------------ESPSQELAAALD-------LRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQTLNVQ---
KGKLS--------TDLFR------TKRSLRYFE---------------------------
-----EESKDLADRLQCSLQRKGELEQVLCAVTATQKKKAN----L--------------
------------------------------------------------------------
--SSSHRKACMEWK--------LEWSTRE-QALLKAQLT---------QLKESLREAHLE
RDEYVE-HLKGERARWQHRMK--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLCK
V---------KNQ-MAKPQHPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSPLNQPQK------ERLG------
-R----------------------------------------------------------
------------------------------------------QEERL---------QQLV
EPHRGVEEL---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------EHLEAARQQN-QQLQDQLSLM--ALPGEGDGG-H-----
------------------------LDSEEEEGPRPM-PSVPED----------------L
ESWEVMSSLMDL--LE---------------------------------------E-K--
------------------------------------------------------------
-TDLRERVEKL----------------------------------EVQFIQYWR--KRCH
Q-KIRHLINEPGGSVKDAAR-GGHIQAG----PGQGGDEGEA--A-GAAGDGVAA-CAD-
NNEH--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQVPTCTPDP-CVSIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-ANEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--ASPHDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSIPEKA-----------TSGGC
QPPRD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------SRSVE-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRVLEVQIQTLNIQ---
KEELN--------TDLYH------MKRSLRYFE---------------------------
-----EKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKAN-------------------
-----------------------------------------------------------Q
--LSSRSKARTEWK--------LEQSMRE-EALLKVQLT---------QFKESFQQVQLE
RDEYSE-HLKGERARWQQRMR--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEKLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKNN--QRISLLNQRQE------ERIREQEERL
RKQEE-R--------------------------------------------------IQ-
-----------------------------------------EQHKSL---------QQLA
KPQSVFKEP--------------------------------NNENKNALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPRPM-PSVPED----------------P
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKK----------------------------------ELCFIHHWR--ERCH
Q-KTHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GHLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFLCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MTGETR
ES----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----AGAKKDG-------KTN--GSVPETG-----------TSGGC
HSPE--DSAT-GILGEGPTSFAP---------------------------------LKEL
-------------ESPCQELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKKTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NETQKA-ERELEVSFSRPPGN---
T---------------EH------AER-ETKYG---------------------------
-----PESKDLADRLQCSSQRTEELEQVLCAVTATQKKKAN----L--------------
------------------------------------------------------------
--SSSHRKARMEWK--------LEWSTRE-QALLKAQMT---------QVRFCRGRE---
----------G-------------------------------------------------
-----------------------------------------------RKMTPES-RGPYC
L---------LPL-SAEPLSPE----PPAVPPEE-------------E--------LQYL
RKELERVSAELQAH-------------VENQ--QHVSLLNQGQK------ERLRRQEEKL
RE----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEQQVEELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAARQQN-QQLQDQLSLK--ALPGEGDGG-H-----
------------------------VDSEEEEGPRPM-PSVPQD----------------L
ESWEAMSSLMDL--LE---------------------------------------E-Q--
------------------------------------------------------------
-TDLREHVEKL----------------------------------EVQFIHYWR--ERCH
Q-KIHHLIHEPGGSVKDAAR-GGHHQAG----PGQGGDEGEA--A-GAAGDGVAA-CAD-
HNNEHGKLPTSSQNP-VEDP-GP-----GAPAPQE-T-----------------------
GDAHKH-------GDLCE---VSL--NDIEEPAH-------GEATE--GSPHKNPAAQ-T
ITQEH---------QEHPG-LGRNRSVQFFCWAWLPRRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPYLPP----HPM-----MLEESR
QN----KLAA--------------------------------AKKKLKEY----------
QQRKS----PGIP-----AGAKTKK-------KKT--DSSPETT-----------TSGGC
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKTN---------NE--IHKAQME-RLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCREAVLQRW--------LQQTIKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KNQ-MAEPPSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEEML
----------------REQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRK
QEERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLALSQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSALQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASHQN-QQLETQLSLV--ALPGEGDGGQH-----
------------------------LDSEEEEAPRPT-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTR---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
NHEGHGKFLIAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DVFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTVQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------K--Q
QKKQVEHQ------LEVEKKAN--------------NEKQR-------------------
--KLN--------TDLYH------MKRSLRYYE---------------------------
-----DESKDVAGYLQHSLQRIAELERALCCHHHTGE-----------------------
-----------------------------------------------------------E
--GDQCDKALIEWQ--------LEQSIQE-KARLKAHLT---------WLKESLKQVQLE
RDEYAQ-HIKGEQ--RQQRMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------HDTCPVEKRE-RSLCK
L---------KNQ-RAEPLLPD-P---PAMPSEV-------------E--------LQNL
RKQLERMAGELQAQ-------------MENN--QRISVLNWGQK------ERLQ------
------------------------------------------------------------
-----------------------------------------EQEKRL---------QQLA
KPQSGFKEL--------------------------------NNENKSALQLEHQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAARLQN-QQLKAQLRPL--WPTPTGDGGGH-----
------------------------LDSEEEEAPRPM-LTVPED----------------L
ESWEAMSSFM--------------------------------------------------
-------------------------------------------------------DLLEE
KTDLT---------------------------------------------------LSSH
R-KVHHLIVEPGDSAKDAAPGGGLHQAG----PGQQGDEGEA--A-GAAG-DDAVACGD-
YNEEHSKFLATAQNP-ADEP-SP-----GAPAPQELGA----------------------
--ANKH-------GDLCE---VSL--TDSVEPAQ-------GEARD--GSPHGNRTSQ-P
IVQDH---------QEHPG-LG-------FCWTWLLRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGIP-----AGGKKKK-K-----IRT--GDSPGRT-----------TADDC
QAPEDIQDIL--KVLVSDLNHSNGVALPPLDKRKAPQNCAAPTSP-------TA-DDTMF
L--GVVPPPDAD---LP-----GKASPQNHDADSCSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKDLE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSNTIEELK--Q
QNQEALDQ------LEKEKKEY---------EQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALGH------TQQAAKQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSAVSTQQKQADRYNKDLTKERDA------LK
LELYKNNKN--TEDLKQQNSELEEKLRVLVA--EKAAAQCGVEEL--QKKLEMSELLLQQ
F-SSQAEAPDSNQQ--------LQQA-MEERAQLEVHVN---------QLMESLKQLQME
RDQYAE-NLRGESTMWQQKMQ--QMAE------------------QV-RTL---REEKE-
--------------------------------------------HSQSQVQELE------
--TSL--AELRSQ-MEEPSSAE----PPAGPSEA------------EQRLQA---EAEGL
QRELELVAGQLHAQ-------------VRDN--ESLSRLNRE-------------QEERL
LELERAAERWSEQDEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKETVELKSQEAQSLQEQRDQYLAH---LQ----QYAAAYQQCTATCEQLTSEKEA
LHKQFLQQTQLMDQLQHEEVQGKMA----------------------------------A
EIARQELKE----------AQERLKATSQEN-QQLQAQLSLL--ALPGEEEVDKEE----
---------------------------QEEESPQPH-LTIPQD----------------L
DSQEAMVAFLKT--ALASAQEAQA--------QLRGQLREQKARCRHLAH-LAAPAHREP
EKEAL----------VSESV-----SSGVSGESHQALQAAMEKL------QSRFLEVMQE
KVELKERVEELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKIKLL---ELQELVLRLVSE
RNEWQGKFLAAAQSP-ADVP-TP-----GSSGPQELGVA-DQ------------------
------------QGDFGE---VSL--ADNAEPAQ-------GEAAA--ASLPENPTAQ-Q
IMQLL---REIQNPQECPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LKEY----------
QQRKS----PGVP-----AGAKTKK-------KKT--GSSPETT-----------TSGGC
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVI-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKTN---------NE--IHKAQME-QLEMSGGWGTINILTLE
KADLK--------ITLYH------TKRAARHFE---------------------------
-----EESEDLAGRLQYSLQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SLSCREAVLQWR--------LQQTIKE-QALLNAHVT---------QVTESLKQVQLE
QDEYAK-RIKGERARWQERMW--KMSV------------------EV-RSD--PSEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KNQ-MAEPLSLV----PPAATSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSVLSKEQK------QRLQEQEEKL
---------------------QEVRELERLCEQNERLREQQKTLREQGERLRKQE-----
--ERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLTLSQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSTLPLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQD-QQLETQLSLM--ALPGEGDGGEH-----
------------------------LDSEEEEAPQPT-PNIPED----------------L
ESREAMVNVTPL--FW--------------------------------------------
-------------------------------------------------LQSSFMDLPKE
KVDGTEQVERP---------ELGFVQPSGVTDGMRESFTIYESQGAVPNTW---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLEVQKLVLPLVG-
NHEGHGKFLTTVQNP-ADEP-AP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLS---PIMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MTE--RRYM
RFRLFQSTSYINGEGLTS-SSMKDLE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------EQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLANRLQSSRQRVGELERTLSAVSTQQKQVDRCNKDLSKERDT------LK
LELYKNNKN--NEDLRQQNSELEEKLRVLVA--EKAATQSGVEEL--QKKLEMSELLLQQ
F-SSQSEASDSSQQ--------LQHA-MEERAQLETHVG---------QLRESLKQLQIE
RDQYAE-SLKGESAMWQQRMQ--CMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRESQVQELE------
--TSL--AELRSQ-MEEPPAPE----PPAGPSEV------------EEWLKA---EVERL
QKELDSLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEERL
LQLERAAERWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKETVELKSQEARGLQEQRDQCLSH---LQ----QYAAAYQQHVAAYQQLTSEKEA
LHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
EIARQELQE----------VQERLEATSQEN-QQLQAQLSLL--ALPGEGEEDHEE----
---------------------------LDEEAPRPS-LTIPED----------------L
DSREAMVAFFNT--AIASAEEEQA--------RLRGQLREQKARCRSLAH-LASPAQSKL
EKEAV----------APGSP-----GDSVSGESHQALEVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKIKLL---ELQELVLRLVNE
RNEWQGKFLAVAQNP-VDVP-TP-----EPAGTQEFGAA-DQ------------------
------------QGDLRE---VSL--ADNVDPAQ-------GEAGA--PTPLENPTAQ-Q
IMQLL---REIQNPRERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MEDVIRLAQKEEEMKV--N-LLELQELVLPLVG-
NHEGHGKFLTAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-QWNS----ADV--GTGATDNKR-K-K-----INN--GTNPETT-----------TSGGC
RSPEDKQQNPAQLEEEKKASHQHQQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-RRQLEAQVHTIQILMCQ
KTELE--------IALYY------SQDATRKFE---------------------------
------ESKDLAGCLHHSWNFAGELQRALSAVSTQHKHADRVSPTTCPVPWE------PS
FA---------DGGMSLKP----------------------------------MSLFPFG
V-QTNTLQEE--------------------------------------------------
-------------KMWRQEEKLQDQ------------------------------EKIRK
QKEKMWRQQDTLREQEEKMRQ---------------------------------------
--------------------------------------------------------QEEM
WRQEQRLREQEKELREQEEQMREQEEKMQEQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EE---KMWEREKK----------MW-----RQEE---------RLRQQEK
---------QMREEE------------K--------------------------------
-----------------------------------------M-----------R---EQE
KMWRQEEKL----RKQEKELRELEEQMREQE-EQMREQEEQM--RELEEQMRELQEQMRE
QEEQMRELE-------EQMRELQEQMREQDEQMREQ-DEQMREQDERLRLKEDTLWEKE-
KMCEEEEKTRGQE--------------------------------------------EKM
RGWTS----------HPGSVEPARGAG---------------------------------
----------------------------------------------DSS--PHDN-CTAQ
Q-----I-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MQLL---PGTKNAHECPV-LGSTSCIPFFYRGDKKKM-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPHPFPP-------------------
----------------------PS-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PGGP-----AVVKKKK-K-----LKY--DSNPETS-----------TAGDD
HSPEDIQDIL--KVLVSDLNRSNGVALPSLDRWQAPKDHAASAPP-------SA-DDTVS
P--GGVPSPGTT---LT-----SMA---------DPNVMDETKTFSSTESLRQL--SQQL
NGLLSESASYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQEF---------QQKLSKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLATRLKSSRQRVGELEKTLSAVSTQQKQAEKYNKELTEERDT------LR
LELFKNNKV--NEDLKQHNSELEERLRILAA--ENAASQLGMEEL--QKKLEMCELLLQQ
F-SSGSASPDSDQR--------FQQA-MEDRTRLETHVG---------QLTESLKQLQLE
RDQYTE-SLKEERAIWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------HSVSQVQELE------
--SSL--AELRSQ-MVEPAAPE----SPAGPSEE------------EQRLQA---EAERL
QKELECLAGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NVEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMELKSQEVQGLQQQREQLLSQ---LQ----QYAAAW-------QQVASEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELRE----------TQERLEATSQQN-RQLQAQLSLL--APPGEGEEVDEED---
---------------------------TEEEAPQPD-VTIPED----------------L
DSREAMVAFCNA--ALASAREERA--------RLLGQLREQRVQCQHLAH-LSATSHRVP
EKEVP----------TPGST-----GDSVSGESHRALQVTMEKL------QRRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVGF----------------
--------LAAARSP-AEEG-RS-----GEGVST---EASAL------------------
------------SKDLRE---VSL--ADSAEPAQ-------EAAVL--GCAPENPTAR-Q
IMQLL---REIQNPEEHPG-LGSNPCIPFFYRADKNDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLPP----HPA-----MSEKTR
QD----KLAA--------------------------------AKKKLKEY----------
QQSKS----PGVP-----AGAKTKK-------KKT--GSSLETT-----------TSGGC
HSPEDSRYQE-------L------------------------------------------
--------------------AVALD-------SNSAT-------------INH-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEEKKAN---------NE--IHKAQME-QLE------TINILMLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLASRLQYSLQRTQELEWALSAVSTQQQEED--------------------
-----------------------------------------------------------R
--MSSTSCPVPWQP----------------GLP----DG---------GVTESLKQVQLE
RDEYAQ-HITGERARWQERMW--KMSV------------------EA-CTL----KEEK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KPQ-MAEPLSPA----PPAGTSEV-------------KQLQD---EARHL
RKEVERLEGKLQSQ-------------VENN--QALSLLSKEQK------ESFRDQEERR
----------------VR-EQERVREQERLREQERVLREQGERLREQGERLRKQEERLRK
EEERLQKEEE------RLLWDQE---------------------ERLALSQNHTLDKQLA
EPHCNFEDL--------------------------------NNENKSALQLEQQVKELQE
KLGE----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQLSVM--ALPGEGDGGGH-----
------------------------LDSEEEEVPWPM-LSIPQD----------------L
ENREA-------------------------------------------------------
--------------------------------------------------MSGFMDLPKE
KADGKEQVEKL---------ELGFIQLSEATDSMREYVTVYESQGAVPNTW---------
-----------------------HQDMEDVIRLAQNEEEMKV--N-TLELPKLVLPLVG-
DHEGHGKFFATPQNP-ADEP-AP-----GAPAPEELGA----------------------
--AGKQ-------GDFSE---VSL--DNSVEPTP-------GEARK--GSPHDNPTAE-Q
IVHLL---PVMQDTQEHPG-LATKPCMPFFYRASENREINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNAATLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESATCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELEGLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAY-------QQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAATQQN-QQLRAQLSLM--AHPGEGDGLDREEEED
---------------------EEEEEEEAVAVPQPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQNP-ADEP-TS-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGSVEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------VG-----ADSS--
HD----DYCS-------------------SFP-------------QLKEC----------
WQRNS----PAVP-----GEAKSNR-------KMN--GSNPETS-----------TSDGC
HSPG--DSAT-GIHGAGPMSSAS---------------------------------LKDL
-------------ENLCQEQAVVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEAQIQRLNIQ---
KRKLT--------IDLYH------TKRSLMYFE---------------------------
-----EESKDLAARLQRSSQRTEELERALSAVAATQKKKK--------------------
------------------------------------------------------------
--SLNRSKTLLKMQ--------LEQSLQE-RALLKVHVT---------QMKESLKQVQLE
RDEYAE-HIKAERAQWQEKMR--KMSQ------------------EV-CTL---KKEKQ-
--------------------------------------------HDMHRVEKLE-RSLSQ
L---------KNQ-RSEPLHPE----PLAVPSEV-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHLSLLNQAQK------ERLRRQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------KQEERI---------QQLA
EPQSGVEEL--------------------------------NNENKSALHLEQ-----QE
KLREV--------ETVTSTQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GESVSEETPWALQEVMEKLEVSESWNSGLMDLLEE
KADLREHVEKL----------------------------------ELLFVQYWRERCPSS
E-KINSPYTEPEGSAKEAGTGGGHHQAG----QDDE-IEG-R----CLTGDAAAA-CAH-
RNKGAQKFLAAARNP-AMSP-NP-----YPRLP---------------------------
----LS-------KDLYE---VSL--TDSAQPAQ-------GEAKK--GSPQDNPTAQ-P
IMQDH---------QEHPG-LGSNRSVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----KLA---------------------------------------------------
------------------------------------------------------------
LAKK--KSAT-GIDGEGPTSSAY---------------------------------LKDL
-------------ESPSQELAAVLD-------SRPVK-------------ISL-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
EKKQVEHQ------LEEEKKAN--------------NERQKA-ERELEVQVQRLNIQ---
KGKLS--------TALYR------TKRSLRYFE---------------------------
-----EESKDLAGRLQHSLQHKGELERAFSATQ--KEED---------------------
-----------------------------------------------------------R
--FSSHRKAHMEWK--------LERSIRE-QAVLKAQLT---------RMKDSLKQVQLE
RDEYAQ-HLKGERARWQERMR--KMSQ------------------EI-RTL---KKEKK-
--------------------------------------------DVMHRVEKLE-RSLSK
L---------KNQ-MAEPLPPE----PPAVPPEE-------------E--------LQHL
RKEVDRVSAELQAQ-------------VENY--QHVSLLNQAQK------ERPWEQEEK-
---------------------------------------------------------IC-
-----------------------------------------EQEERL---------QQLA
EPQSGVEEL--------------------------------NNENKSALQLEQQVEELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------KEHLEAASQQN-QQLTAQLRLM--ALPGEGDGGEH-----
------------------------LDSEEAAAPQPL-PSVPED----------------L
ESWEAMSGLMDI--LE---------------------------------------E-T--
------------------------------------------------------------
-ADLSELVKKP----------------------------------ELR--LYWG--QRCH
Q-NVPQLIIEAGGSAKDAAMGGGHHQAG----PAQGGDEGES--A-GAAGDAVTA-CRE-
YN-KHSRFLAAAQNP-ANEP-GP-----GAPDP-QEL-----------------------
VAADQH-------GDLCE---VSL--TDSTQPAQ-------GEARE--GSPQDNPTAQ-P
IAQE---------HQEHPG-LGSNCCVPFFCWAWLPRRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPT-----MLEETR
QS----KLAA--------------------------------AKKKLKEY----------
QQRNS----PGVP-----AGVKMKK-------KNT--GSIPETA-----------TSGGC
HSPGDSRYQE-------L------------------------------------------
--------------------ELALD-------SSSAI-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEEKKTN---------SE--IHKAQME-QLE------AINILTLE
KTDLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCSEAVLQWR--------LQQTIKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMW--KMLV------------------EA-RTL---KKEKK-
--------------------------------------------RDIHRIQELK-RSLSE
L---------KNQ-MAEPPSPA----LPAVTSVV-------------EQLQD---EAKHL
RQEVESLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQDERL
----------------REQEEWRVQEQERLCEQNERLREQQKTLREQGERLRKQEQRL--
-----CKQEERLQKQEKRLWDQEESLWEKEERL-------QKQEERLMLSQNHKLDKQLA
EPQCGFEDL--------------------------------NNEKKSALQLEQQVKELQE
RLGE----KETV----TS-APSK-KGW---------------------------------
------------------------------------------------------------
----------------------EEPAASHQN-QQLETQLSLV--ALPGEGDG-EH-----
------------------------LDSEEEEAPRST-PPKH-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------PRGPGEPGGHGEYITEYESQGAVPNTR---------
-----------------------HQEKEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
DHEAHGKFLTAAQNP-TDEP-AP-----GAPAPQELGA----------------------
--ADEQ-------GDFYE---VSL--DDSEEPAP-------GAARE--GSPHDNPTAQ-Q
MVQLP---PVMQDTQEHPG-LPSNPCVPFFYQAAENREINIII-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------E--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-ERELEVQIQRLNRQ---
IKKLN--------MDTYH------TERSLRYFK---------------------------
-----EESKDLSGRLQHTVQRIGELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LERSIQE-KARLKECLT---------RMRESLKKAQLQ
RDEYAQ-HLKGERARWQERMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------DVMHWVEKLE-RSLSK
L---------KNQ-TAEPLPLE----PPAVAPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHVSLLNQAQK------ERLRRQ----
---EE-K--------------------------------------------------LR-
-----------------------------------------EQEERL---------QQLA
KPQSGVEEL--------------------------------NNENKCAPQVEQQAAELLE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASQQS-QQLNAPLNLM--ALPGEGDGGGH-----
------------------------LDSEEEEGPRPM-PSVPED----------------L
ESWEAMSGIMDH--WE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVKKQ----------------------------------ELPSIQYWG--ERCH
Q-NVHLLIIEEGGSAKDAAMGGGHHQAG----PAQGGDEGEA--A-GTAGDAVVA-CAD-
LNNKHSKFLAAAQNP-AHEP-SP-----GAPPP-QEL-----------------------
GAANQH-------GDLCE---VSL--TDSAEPAQ-------GEAKE--GSPNDNPTAQ-P
IVQD---------HQEHPG-LGSNRSGPFFCWAWLRRRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLEVRGPGPWPSDPGGQPSNLLPQRGLGAPLPAETAH
TPPSPNDCSLYLSPQSSSNSSSLHAPQSRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREEE--
--------------------------EEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-ANEP-DP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLPP----HSA-----MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----AGAKKNR-------KTN--GSSPETA-----------TSGGS
HSPG--DSAT-GIDGEGPMSSAP---------------------------------LKDL
-------------ESPSQELAAVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNIIKS-----
-LWVSPWGPEERGWGSLK-KAN--------------NEKQKT-ERELEVQIQRLNRQ---
IKELN--------TDMNH------TKRSLRYFE---------------------------
-----EESKDLAGRLQQTLQCIEELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LEQSIQE-KARLKAQLT---------QMKDSLKQAHVD
REEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTHRVEELK-RSLSK
L---------KHQ-MGEMGL---------VPGI------------------------RGL
WRGLEC------------------------P--REV-----------------G------
------------------------------------------------------------
---------------------------------------------------------GWK
GFEAEGKRS--------------------------------NNKNKSALQLEQQVEELQE
TLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEASSQQS-QELNAPLNLT--ALPGEGDGGEH-----
------------------------LGSEEEEAPQPM-PSVPQD----------------L
ESWEAMSGCMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSVEDAAMGGGHHQAG----PAQGGDEGRV--R-R-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PH-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GSSPEKT-----------TANDC
QSPEDIQDIL--KVLVSDLNRSNGVSLPPLDKRKAPTDHTAPAPP-------TADDDTMF
L--GVVPSSDAD---LT-----SMASPQSHDAGNSSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKRDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADKYNKDLTKERDA------LK
LELYKNNKN--NEDLKQQNSELEEKLRVLVA--EKAAAQSGVEDL--QKKLEMSELLLQQ
F-SSQSEASDSNQQ--------LQHA-MEERAQLETHVG---------QLMESLKQLQME
RDQYAE-NLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRESQVQELE------
--TSL--AELRSQ-MEEPPPPP----PPAGPSEV------------EQRLQG---EVEQL
QKELENLTEQLRAQ-------------VQDN--ESLSHLNRE-------------QEERL
LELERAAERWSEQTEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGELQE
RLGELKETVELKSQEAQSLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
VHKQLLLQTQLMDQLQHEEVQSKMA----------------------------------A
EMARQELQK----------TQERLEATSQEN-QQLQAQLSLL--ALPGEGDEEQEE----
---------------------------QEEEAPRPS-LTIPED----------------L
DSKEAMVAFFNT--AIASAEEEQT--------RLRVQLREQKARCRSLAH-LSTPVQSK-
---------------IPSNV-----SDSVSEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKIKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-VDVP-TP-----VPTGSQGFGAA-DQ------------------
------------QGDLRE---VSL--ADSIEPAQ-------GAPGA--LTPPENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------VG-----ADRS--
HE----DYCS-------------------SFP-------------QLKEY----------
WQRNS----PAVP-----GEAKSNR-------KTN--GSNPETS-----------TSDGC
HSPG--DSAT-GIHGVGPTSSAS---------------------------------LKDL
-------------ESLCQEQAVVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEAQIQRLNIQ---
KRKLT--------IDLYH------TKRSLMYFE---------------------------
-----EESKDLAARLQRSLQRTGELERALSAVAATQKKKK--------------------
------------------------------------------------------------
--SLNRSKTLLNTQ--------LEQSLQE-RALLKAHVT---------QMKESLKQVQLE
RDEYAE-HIKGERAQWQEKMR--KMSQ------------------EV-CTL---KKEKQ-
--------------------------------------------HDMHRVEELE-RSLSQ
L---------KNQ-RSEPLHLE----PPAVPSEV-------------E--------LQHL
RKELERVSAELQAL-------------VENH--QHLSLLNQAQK------ERLQRQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------KQEERI---------QQLA
EPQSGVEEL--------------------------------NNENKSALHLEQQVEELQE
KLREV--------ETVTSTQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GESVSEETPWRPYGSPGGEEM--------------
------------------------------------------------PISEWEARARQG
E-KINHLITEPEGSAKEAALGGGHHQTG----GAAG-AAG-A--A-GAAGDAAAS-CAH-
RNKGHSKFLAADQNP-ANEP-GP-----EAPPPRS-L-----------------------
GLL----------TNLYE---VSL--TDSAQPAQ-------GEARK--GSPQDNRTAQ-P
IMQDH---------QEHPG-LGSNRSVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQSSLPP----DPM-----MPEETR
WN----KLAA--------------------------------VKKKLKEY----------
QQRKS----PGVP-----AGAKTKK-------KKT--GSSPEAT-----------TSGGC
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKAN---------NE--IHKAQME-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYALQRIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SLSCREAVLQWR--------LQQTIKE-QALLNAHVT---------QVTESLKQVQLE
QDKYTK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELK-RSFSE
L---------KNQ-MAEPLSLV----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEEKLQSQ-------------VENN--QALSVLSKEQK------QRLQEQEEMI
----------------REQEVQRVRELERLCEQNERLREQQKTLQEQGERLRKQEQRLHT
QEERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLVPFQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSTLQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQD-QQLETQLSLM--ALPGEGDGGEH-----
------------------------LDSEEEEAPRST-PNIPED----------------L
ESPEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTW---------
-----------------------HQEMEDVIRLAQKEEEMKM--N-LLELQELVLPLVG-
NHEGHGKFLTAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------LKESLKQAQLE
RDEYAQ-HLEGEEARWQQRMR--KMLQ------------------EV-RTL---KEERQ-
--------------------------------------------QDMRQVEKLE-RRLST
L---------KNQ-MAEPLPPE----PPAVSPEE-------------E--------LQHL
RKELGRVSAELQAQ-------------VENH--QHVSLLNQAQK------ERLREQEER-
---------------------------------------------------------LR-
-----------------------------------------EQEERL---------QQLA
-----------------------------------------NNENKSALQLEQQVEELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLHLM--ALPGERDGGGH-----
------------------------LDSEEEEAPEPM-PSVPED----------------L
DSWEAMSGLMDI--LE---------------------------------------E-K--
------------------------------------------------------------
-ADLSELVKKQ----------------------------------EPPSIQYWG--ERCH
Q-NIHHLIIEAGGSSEDAAMGGGHHQAG----PAQGGDEGES--A-GAAGDAVTA-CRE-
YN-KHSKFLAAAQNP-ANEP-GP-----GAPAP-QEL-----------------------
VAAHKH-------GDLCG---VSL--TDSSEPAQ-------GEARE--GSPHDNLTAQ-P
IAQD---------HQEHPG-LGSNRSVPFFCWAWLWRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQHCLPS----HPT-----MLEETQ
QR----KLAA--------------------------------AKKKLKEY----------
QQRNS----SGVP-----AGTKTKK-------KKT--GSSPERT-----------TSGGC
HSPGDSWNQE-------L------------------------------------------
--------------------KVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LCENIESLV---
-RKQVEHQ------LEKEKKAN---------NE--IHEAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARCFK---------------------------
-----EESKDLAGRLQSSLQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LQQTRKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAQ-HIKGERAQWQERMW--KMSM------------------EA-HAL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
R---------KPQ-MAEPSSSA----PPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGKLQSQ-------------VENN--QQERL---------------QKQEEKI
---------------------------QELCEQKERLREK--------------------
----------------------QKRLWEKEERLRKQEERLRMQEERLLLSQNHKFDKQLA
EPQCDLEDL--------------------------------NNENKSTLQLEQQIKELQE
KLSK----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAAGQQN-QQLEAQLSLM--ALPGQGNEGGH-----
------------------------LDGEEEEVPQLM-PSIPKG----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------MSGFMDLPRE
KVDGEEQVENL---------ELGFIQLSGATDGMREHFTVYGSQGAVPNTW---------
-----------------------HQEEEDVSSLAQNEEEMNV--K-LLELQELVLPLVS-
DHEGHDKFLPTAQNP-ADEP-AP-----GAPAPQELGA----------------------
--AHEQ--------DFYE---VSL--ANSMEPAP-------GEDRE--GSPHGNPTAQ-K
IVQLL---PVMQDTQEHPG-FASKPCVPFFYRAAENREIKIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MEWK--------LEWSTRE-QALLKAQLT---------QLKESLKEAHLE
RDEYVQ-HLKGERARWQQRMK--KMSQ------------------EV-YTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNR-MAKPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQTLK------ERLR------
-E----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQSGRHQVL-------------------------G-SPVSNNENKSALHLEQQIEELQG
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAARQQN-QQLQDQLSLM--ALPGEGDGGEH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGLMDL--LE---------------------------------------E-Q--
------------------------------------------------------------
-TDLRERVEKL----------------------------------EVQFIQYWR--ERCQ
G-MAGGA-PGPGAPAPQETG-DAHKHGG----DGVGGD-----------GRGL-H-CAQ-
IPH--------S-------L-SP-----N-------------------------------
SQLPLS-------KDLCD---MSL--TDSQEPAH--------EATE--GSPHNNPAAQ-T
ITQEH---------QEHPG-LGSSRSVPFCCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PH-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----AGVP-----AGAKKKK-K-----IKN--GSSPEKA-----------TTNDC
QSPEDIQDIL--KVLVSDLNRCNGVSLPPLDKRKAPTDRAAPAPP-------AAADDTMF
L--GVVPSPDAD---LT-----SMASPQSHDAGNCSDLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKRDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDA------LK
LELYKNNKN--NEDLRQQNSELEEKLRVLVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSEASDSNQQ--------LQHA-MEERAQLETHVG---------QLMESLRQLQME
RDQYAE-NLKGESAMWQQRIQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HKESQVQELE------
--TSL--AALRSQ-MEEPPPPK----PPAGPSEV------------EERLQG---EVEQL
QKELENLMGQLKAQ-------------VQDN--ESLSLLNRE-------------QEERL
LELERAAERWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGELQE
RLGELKETVELKSQEAQGLQEQRDQYLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
VHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
EMARRELQE----------AQARLEATSQEN-QQLQAQLSLL--ALPREGDVEQEE----
--------------------------EEEEEAPRPS-VTIPED----------------L
DSKEAMVAFFNT--AIASAEEEQA--------RLRVQLREQKARCRSLAQ-LAAPVQSKL
EKETE----------VPRNV-----SDSVSEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVSE
RNEWQSKFLAVSQNP-VDVP-TP-----VPTGSEELGAA-DQ------------------
------------QGDLRE---VSL--ADSVEPVQ-------GKAGP--PAPPENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MKA--N-TLELQKLVLPLVG-
DHEGHGKFFTSPQNL-ADEP-AP-----GAPAPEELGA----------------------
--AGEQ-------GDFYE---VSL--DNSMEPTP-------GEARK--RSPHDNPTAQ-Q
IMHLL---PGMQDTQEHPG-LASKPCVPFFYQASEDREINIIIV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPHPFPP-------------------
----------------------PS-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PGGP-----AVVKKKK-K-----LKN--DSTPETS-----------TAGDD
RSPEDIQDIL--KVLVSDLNRSNGVALPSLDRWQAPKDHAASAPP-------SA-DDTVS
P--GGVPSPVAA---LT-----SVASLQNCDADSDPNVVDEAKTFSSTESLRQL--SQQL
NGLLSESTSYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQEF---------QQKLAKEQVSL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLATRLKSSRQRVGELEKTLSAVSTQQKQAEKHNKELTEERDT------LR
LELFRNNKS--SEDLKQHNSELEERLRVLAA--ENAARQLGVEEL--QKKLEMSELLLQQ
F-SSGSVSHDGDQQ--------FQQA-VEDRARLETHVG---------QLTESLAQLQLE
RDQYTE-NLKEERAVWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------RSVSQVQELE------
--SSL--AELRSQ-MAEPPAPQ----PPAGPSGE------------EQRLQA---EAERL
QKELERLAGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFIRLTNE---NMEMTNALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMELKSQEVQGLQQQREQLLSQ---LQ----QYTAAW-------QQVTSEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELRE----------TQERLEASSKQN-RQLQAQLSLL--ALPGAGEDVEEEEEEA
-------------------------EEAEEEAPQRD-VTIPED----------------L
ESREAMVAFCNA--ALSSAREERA--------RLRGQLREQRAQCRRLAH-LVARSHSEP
GKEVP----------TPGST-----GESESGENHRALQVAMEKL------QSRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWQGRFLAAARSP-AGEP-AP-----GPGDAQGLGAATAE------------------
------------QGDLLE---VNL--ADSAEPAQ-------DVAGP--GSAPENPTAR-Q
IMQLL---REIQNPEEHLG-LGGSPCIPFFYRADRNDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPYLPP----HPM-----MLEETR
QK----KLAA--------------------------------AKKKLKEY----------
QQRNS----PAVP-----AGAKTKK-------KKT--GSSPETT-----------TSSGC
HSPGD--YQE-------L------------------------------------------
--------------------ATALQ-------SSSMT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLIRKQ
QKEQPEHQ------LEEAKKAN---------NE--IHKGQTE-QLE------AINILTLE
KEDLK--------TALYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALCAVSTQQREED--------------------
-----------------------------------------------------------R
--SSSCSEAILQRR--------LQQTLKE-RALLNTHVT---------QVTESLKQVHLQ
REEYAH-CIKAERARWQERMR--KISL------------------ET-LLL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLLE
F---------QNR-MAEPPSLA----PPAVTSVV-------------EQLQD---EAKQL
RKEVEVLEGKLQSQ-------------VKNN--QALSLLSKEQK------QRLQEQEQRL
----------------QEQEEQRAREQERLCQQKEMLRQK-EMLREQGKRLRKQEQRLRK
EEERL-----------------------------------RKEEERLALSQNHKLDKQLA
EPQRGFEDL--------------------------------NNENKSAVHSEQGVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQWN-QQLETQLSLK--ALPGEGTGDHS-----
------------------------EEE--ERAPAGM-GD---------------------
------------------------------------------------------------
--------------------------------------------------------Y---
-QKGSRSGLPH---------QLVVIQPSGATDGMRESFTVYESQGAVPNTR---------
-----------------------HQEMEDVIRLARNQEEIKV--K-LLELQELVLPLVG-
NHEGHGKFLTAAQNP-ADEP-AP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNSVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLL---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPHPFPP-------------------
----------------------PC-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PGGP-----AVVKKKK-K-----LKN--DSDLETS-----------TAGDD
HPPEDIQDIL--KVLVSDLNRSNGVALPSLDRWQAPKDHAASAPP-------SAADDTVS
P--GGVPSPGTP---LT-----SVASLQNCDADSEPNVMDETKTFSSTESLRQL--SQQL
NGLLSESTSYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQES---------QQKLAKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLAGRLKSSRQRVGELEKTLSAVSTQQKQAEKYNKELTEERDT------LR
LELFKNNKS--NEDLKQHNSELEERLRVLTA--ENAASQLGVEEL--QKKLEMSELLLQQ
F-SSGSASPDADQQ--------FQQA-LEDRARLETHVG---------QLTESLRQLQLE
RDQYTE-NLKEERAMWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------RSVSHIQELE------
--SSV--AELRSQ-LAEPPAPE----PPAGPSEE------------EQRLQA---EAERL
QKEVEHLTGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NMEMASALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMDLKNQEAQGLQQQRDQLLSQ---LQ----QYAAAW-------QQVSSEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELQE----------TQERLEATTQQN-WQLQAQLSLL--APPEGGAEVDEEDK--
----------------------------EAAAPLPD-VTIPED----------------L
DSREAMVAFCNA--ALASAREEQV--------RLLGQLREQRAQCRRLAH-LAAASQGEP
EKAAL----------APGSG-----GDSVSAESHWALQVAMEKL------QSRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWQGRFLAAAHSP-AEEP-AP-----GPEDAQELGAAVPE------------------
------------QGDLRE---VSL--ADSTEPAQ-------EAAGP--GSAPENPTAR-Q
IMQLL---REIQNPEERPG-LGSNPCIPFFYRADKNDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSEKT---RQNKLAEAKKKFTDY----------
RQWNI----AGV--GTRATDTKK-K-K-----INN--GTNPETT-----------TSGGC
HSPEDKQQNRAQLKEEKKASHQHQE-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-RREIEAQDHTIRILTCQ
KTELE--------TALYY------SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVS
TSLIPGESKDLAGHLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDA------LS
LELYRNIIT--NEELKKKNAELQEKLRLAES--EKSEIQLNVKEL--KRKLERDKILLPQ
V-QTNTLQEE--------------------------------------------------
--------------TWRQ-----E-------------------------------EELRE
QEKK--------------------------------------------------------
------------------------------------------------------------
--------------------MRKQEEK---------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MW-----RQEE---------RLREQEG
---------KMREQE----------------------GKMREQ-EK--------------
-----------------------------------------MREKE--------------
-------ER-------------------------IREQKEKM--Q--------------E
---------------------------------------RLPEHEERCSEPCL--PPSK-
VLCN--------------------------------------------------------
---MS----------HTGSVEPAGGEA---------------------------------
----------------------------------------------GEGS-PQDN-PSAQ
E-----I-------------------MQLF--------------C-GM------------
------------------------------------------------------------
------------------------------------------------------------
-----------KNAQQRPG-LGSNFCIPFFYRGDKKKM-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------ERLEAASQQN-QQLTAQLSLM--ALPGKGDGGEH-----
------------------------LDSEEEEAPRPI-PSIPQD----------------L
ESREAMSGFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVEKE----------------------------------ELGFFQYYR--ERCH
Q-KVYHPITKPGGSAKDAAPGGGHHQTG----PGQGGDEGEA--A-GAAG-DGVAAGGD-
Y-KGHSKFLVTAQNP-AHEP-SP-----GAPAPQELGA----------------------
--AHKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFRWVWLPRRRK--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPYLPP----HPM-----MLEESR
QN----KLAA--------------------------------AKKKLKEY----------
QQRKS----PGIP-----AGAKTKK-------KKT--DSSPETT-----------TSGGG
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKTN---------NE--IHKAQME-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALSAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCREAVLQRR--------LQQTIKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KNQ-MAEPPSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEEML
----------------REQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRK
QEERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLALSQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSALQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQRN-QQLETQLSLV--ALPGEGDGGQH-----
------------------------LDSEEEEAPRPT-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTR---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
NHEGHGKFLIAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNNVEPAP-------GAARE--GSPHDNPPVQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------PA-----GA-KKNR-------KTN--GGVPETA-----------TSGGC
HSPAD--SAT-GILGDGHTSFAP---------------------------------LKEL
-------------ESSCQELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKKTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKT-ERELEVQIQRLNMQ---
KRKLS--------TDLYH------TKRSLRYFE---------------------------
-----EESKDLVSRLQCSLQHIGELEQALSAVTATQK-KAN-------------------
-----------------------------------------------------------Q
--FSSRSQALIEWQ--------LERSIQE-KARLKARLT---------RMKESLKQAQLE
RDEYAQ-HIE-ERARWQQRMR--KMLQ------------------EV-CML---KKEKK-
--------------------------------------------HDTHQVENLE-RSLSK
L---------KNQ-MAEPLPPE----PPAVPSEE-------------E--------LQHL
RKELKRVSAELQAQ-------------VENN--QRVSLLNRGQN------KRLR------
------------------------------------------------------------
-----------------------------------------EQEERL---------QQLA
EPQSDFEEL--------------------------------NNENESALQLEQQVEELQE
KLDEV-------REMVTSAP-SK-KGWEAGTSLWGGVCQAR-D-----SSSLGA------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------G-----D------------------------TSHFMDHLEE
KVNL--------------------------------------------REQYWR--ERCH
Q-----------TTSS--------------------GWPSEA--A-GALGDAVTA-CGD-
YNKENHKFLATAQNP-ADEP-GP-----GAPVPQEL------------------------
GAADKEC-------WHCT---QIP--TS-NSPKI-----------------FERPRRV-L
PTTTILHSQSAQEHQEHPG-LGSNCSVPFFCWAWLQRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------ME-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELGRALSAGSTQQQEED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LRQTRKE-RALLNAHVT---------RVTESLKQVQLE
RDEYAQ-HIKGERAQWQERIR--KMSM------------------EA-HAL---KEEKK-
--------------------------------------------RDIHRMQELE-RSFSE
L---------KHQ-IAEPPSPV----DPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGKLQFQ-------------MENN--QALSLLSKEQK------ERLQEQEERL
REQQE--R-------LQKQEERRLREEERLCEQKERLREKQKRLGEQGERLRKQEERLRK
EEERLQKQE--------------ERLWEKEERLRKQEKKLQMQEERLALSQNHKFNKQLA
EPQCSFEDL--------------------------------NNKNKSALQLEQQVKELQE
KLSK----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQSSLM--ALPGQGDGGGH-----
------------------------LDTEEEGVPRPM-PTIPKD----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSGFMDLPRE
KVDGKQQVVKR---------ELGFIQLSGATDGMREHITVCEIQGAGPNTQ---------
-----------------------HKEE-EASRLAQKEEEMKV--K-LLELQDMVLPVVG-
DHEGHDKFLPAAQNP-LDEP-AP-----GAPAPQELAA----------------------
--AEEQ-------SDFQ----------YSVEPAP-------GQARE--GSPRDNPTAQ-K
ILQLL---PVTQDTQEHLG-LATKPCVPFFYRAAKNREINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQEPAVVLD-------SRSVE-------------IGQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRELEVQIQTLNIQ---
KEELN--------TDLCH------MKRSLRYFE---------------------------
-----EKSKDLAVRLQHSLQRKGELESVLSDAMATQKKKAN-------------------
-----------------------------------------------------------Q
--XXXX------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXXXX-QQLTAQPSLM--ALPGEGHGREH-----
------------------------LASEGEEAPQPM-PSVPED----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSKLVKKK----------------------------------ELCFIRHWR--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDDGEA--A-AAAA-DGIAAYSN-
YNNGHRKFLAAAHNP-ADEP-SL-----GAPAAHELGA----------------------
--ADKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFRWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQTRLPP----HPA-----MAEETQ
QS----KLAA-------------------AKK-------------KLKKY----------
WQRNS----PGVP-----ARVKRNR-------KTN--GSVPETA-----------TSGGC
HLPG--DSAT-GIGGEGPTSSAP---------------------------------LKDL
-------------ESPCQELAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
EKKQVEHQ------LEEEKKAN--------------NETRKA-ERELEVRIQRLNIQ---
KGKLS--------TDLFH------TKRSLRYFE---------------------------
-----EESKDLAGCLQCSSQHTGELEQALSAVTATQKKKVD----RQ-------------
------------------------------------------------------------
--SSSHRKARMEWK--------LEWSTRE-QALLKAQMT---------QLKESLRQAHLE
RDEYVQ-HLKGERARWQQRMK--KMAQ------------------EV-CTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNR-MAKPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENQ--QHVSLLNQGQK------ERLRRQEEKL
RE----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEQQVEELQE
KVG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQK-QQLTAQLRLM--ALPGKGDGGQH-----
------------------------LDSEEEEGPRPM-PSVPQD----------------L
ESWEVMSGLMDL--LE---------------------------------------E-K--
------------------------------------------------------------
-ADLREHVEKL----------------------------------EVQFIHYWR--ERCH
Q-KIRHLINESGGSVKDVAL-RGHHQAG----PGQGGDEGEA--A-GASGDGVTA-CAD-
HNHQHSKLLTSSQNS-AHEP-GP-----GAPAPQE-L-----------------------
GAAHKH-------GDLRD---MSL--TDSTETGQ-------GEARE--GSPHNNPTAQ-P
ITQEH---------QEHPG-LGSNRSVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MECPAQ--------------------
-----------------------------------------------------------K
--SSSHSKACMEWK--------LEQSLRE-QALLKAQLT---------QMKDSLKQAHLE
RDEYAQ-HLKGERARWQQRMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------DNMRLVEKLE-RSLLK
L---------KNQ-MAKPLPPE----PPAVPAEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QH-------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------NNENKSALQLEQQVEELQE
TLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQK-QQLTAQLRLM--ALPGEGDG-EH-----
------------------------LDSEEEEGPRPM-PSLPED----------------L
ESWEAMSGFMDH--RE---------------------------------------D-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLITEAGGSAEDAAMGGGHHQAG----PAQGGDEGEA--A-GAAGDAVMV-GSD-
YNNKHSKLLTSSQNP-AHEP-GP-----GAPDP-QEL-----------------------
GAAHKH-------GDLCE---VSL--TVSGETGQ-------GEARE--GSPHDNPTAQ-P
IVQD---------HQEHPG-LGSNLCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQHCLPS----HPT-----MLEETR
QR----KLAA--------------------------------AKKKLKEY----------
QQRNS----SGVP-----AGMKTKK-------KKT--RLSPPTS-----------SHSGG
WVPLCHRYQE-------L------------------------------------------
--------------------EVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LSENIESLK--Q
QKKQVEHQ------LEEVXXXX---------XX--XXXXXXX-XXX----------X---
---------------------------PTETTE---------------------------
-----ETSGTSAGRKAPT------------HLAHSQPGEE--------------------
-----------------------------------------------------------G
--SSLS-----------------FHHIPT-GSLITWSHG---------WVTKSLKQVQLE
RDEYAQ-HIKGERARWQERMQ--KMSM------------------EA-PTL---KEEKK-
--------------------------------------------CDIHRIQELE-MSLSE
L---------KNQ-MAEPPSSA----PPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGKLQSQ-------------VENN--QALSLLSKEQK------ERLQEQEERL
----------------QEQQE----------------------------KLQKQEERLRE
-------QEERRLQEQERQCEQKERLWEQQKRLGEQGERLRMQEERLALSQKHKFNKQLA
EPQCSFEDL--------------------------------VEQKHTA--LEQQVKQLQE
KLSE----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAANQEN-QQLEAQLSLM--ALPGQGDGGGH-----
------------------------LDTEEEGVPRPM-PSVPED----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------TSGFMDLPKE
KVDGKEQVENL---------ELGFIQLSGATDGMREHFTVYGSQGAVPNTR---------
-----------------------HQEEEDVSSLAQNEEEMNV--K-LLELQELVLPLVG-
DHEGHDKFPPAAQNR-GDEP-AP-----GAPAPQELGA----------------------
--AHEQ-------GDFYE---VSL--ANSVEPAP-------GEDRE--GSPHDNPTAQ-K
IVQLL---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MSEET---RQSKLAAAKKKLREY----------
QQKNS----PGV-------GAKKKR-K-----IKN--GSSPETT-----------TSNDC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKAPKDRAAPAAP--------TVDDTVS
P--GGVPSPCASLPRVT-----SMTSNQNHDAENGPILIDDSKCLSSTESLRQL--SQQL
NGLVSESSSYINGEGLASSANIKDLE----------------------------------
---------------------------SRYQELSLALDSSNLT--NKQLSSKIEELK--Q
QNQETLDQ------LEKEKKEF---------EQKLAKEQGSL-REQLQVHIQTIGILVSE
KTELQ--------TALVH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVSELERTLSAVSTQQKQVDRHNKDLTKERDT------LK
LELYKNNKN--NEDLKQQNSELEEKLQVMVR--EKAAMQLGMEEL--QKKLEMSELLLQQ
F-SSQSKSPDSSQE--------LHQA-LEERTQLEAHVG---------ELRDLLKQLQLE
RDQYAE-TLKEENAIWQQKMQ--QMSE------------------QM-HRL---REEKE-
--------------------------------------------HSMSQVQELE------
--ANL--AELKNQ-IVVPPA----QEPPARPLEE-----------EQQRLHA---ETEQL
QKELESLAEQVQAQ-------------VKDN--EGLSRLNRE-------------QEQRL
LELERAAECWGEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLV
ELQNGFVKLSNE---NMEITTALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKEMVELKSQEAQNLQQQRDQYMSH---LQ----QYMAAY-------QQLASDKEL
LHKQVLLQTQLMDRLQHEEVQGKVA----------------------------------A
EKALQELQE----------TQGRLESATQQN-QQLQAQLSLM--AMPGEGDGLDSEE---
---------------------------KEEEAAQPK-LSMPEN----------------L
ESREAVVAFFNS--ALASAEEEQA--------RLRGQLKKQKLRCQRLAH-LVAPGQQVQ
EE-------------AAAPS-----GDSVPGETHQALQVAMDKL------QGRFLELMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKENMKMKLL---ELQKLVLCLVSE
RNERQGKLLAAAQDP-AAEP-AT-----APP-AQELGAANGQ------------------
------------GGSLAS---GPEWEQGGRAWEQ-------GERLSMN------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQVSTCTPDP-CVSIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-VEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----SPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLESVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEDVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMGLMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-AHEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----AGAKKKK-K-----IKN--GSSPETT-----------NSGDC
HSSED-----------------------------TPKDNAASLQP-------S--DDTVL
P--GSVPSPGAS---LT-----SMVVPQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNVTIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QVSE------------------QV-HTL---REEKE-
--------------------------------------------RSMSRVQELE------
--TSL--AELRNQ-MAEPSPPE----PPAGPSEV------------EQQLQA---ETEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KK-------ELGKKLGELQE
KLSELKETVDLKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVAAYQQLTSEKEA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
DMASQELQE----------IQERLEAVSQQN-QQLRAQLSLI--AHPGEGDGLDREDEEE
---------------------E------EEEAPWPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------KLRGQLKEQRVRCRRLAH-LLASAQ-EP
EGAAP----------PPETG-----GDSVCGETHRALQEAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVND
RNEWHSRFLAAAQNP-ADKP-NP-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGS-EPAQ-------GETGE--GSSRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPHLPC-------------------
----------------------PS-PGMSEET---RRSKLAAAKKKLREY----------
QQRNS----PGVP-----AGAKKKK-K-----IKN--GSNPETT-----------TTDDC
NSPEDIQDIL--KVLVSDLNHSNGVVLPPLDKWKAPQDCAAPVPP-------SAA-DPVL
P--ASVPSPDAG---IA-----SMASLQNYDADDGPDLMDETKTFSSTESLRQL--SQQL
NGLVSESTPYVNGEGLTSSTNMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KSELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSAVSTQQKQADKYNKELTKERDA------LK
LELYKNNKN--NEDLTELNSELEERLQVLLT--EKEAMQLGMEEL--QKKLEMSEVLLLQ
F-SSQSESPDSNQQ--------LQQA-MEERAQLERKVE---------QLTELLKQLQVE
RDQYAE-NLKEESAVWKQKIQ--QVLE------------------QM-RML---KEEKE-
--------------------------------------------RSANQVLELE------
--TNL--AELKSQ-LAESSLPP----APVGPSEA------------EQQLQA---EAQQL
QKELENLAGQLHAQ-------------VQDN--ENLSRLNQE-------------QEERL
LALEREAEVWNEQAEDRKQILETM------------------------------------
------------------------------------ESNRTTIS--RALLQNRELKEQLA
ELQDGFVRLSNE---NMELTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHMVAYQQLASEKEA
LHQQFLVQTQLLDQLQHEEVQGKVV----------------------------------T
DMVRKELQE----------TQKRLETTSQQN-QQLQAQLGLL--AVPAEVDEADKE----
--------------------------E-REEDAQPR-LTIPED----------------L
DSREAMVAFCNE--ALASAEEEKA--------QLRRQLREQKEHCQRLAQ-LAAPSQSEA
KQDAM----------GLGSG-----GDSVSGESQQAIQMSMEKL------QSRFLEVMQE
KMELKERVEELEHRC---------IQLSGETDTIGEYIALYQNQRAFLKERHREKEEYIS
R-------------------------------LAQDKEDMKVKLL---ELQELVLRLVGE
RNQWQGRFLAASQSP-AAEP-TP-----DPSSSQELEAA-YE------------------
------------QGDLRE---VSL--SDHVDPVP-------GEAAV--ASPPENPTEQ-Q
ILQLL---REIQNPQEYAG-LGSNPCIPFFYRADENDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQLCLPP----HPM-----MLEETQ
QS----QLAA--------------------------------AKKKLKEY----------
QQRNS----PGVL-----AGVKTKK-------KKT--GSSPETT-----------TSGGC
HSPGDSQNQELE------------------------------------------------
---------------------VALD-------SSSTT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LYENIESLV--R
SSVFL---------FLQEKKAN---------NE--INKAQTE-QLE------TINILTLE
KADVK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGCLQYSLQRIQELERALSAVSTQQQEED--------------------
-----------------------------------------------------------R
--V-----TVLQRQ--------LQQTRKE-RALLNAHMT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMR--KMSV------------------EA-HTL---KEEKK-
--------------------------------------------HHIHRIQELE-RSLSR
L---------KHQ-MGKMGLVT----GI--------------------------------
------------------------------------------------------------
------RGLWGGLECHREVGGW--------------------------------------
------------------------------------------------------------
------KSF--------------------------------EAE-------------GKR
SVPA----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQFSLM--ALPGQGDGGGH-----
------------------------LDTEEEGVPWPM-LSIPED----------------L
ESREV-------------------------------------------------------
--------------------------------------------------TSSFMDLPRE
KVDGKQQVENL---------ELGFIQLFGAIDGMREHITVYERP----NTR---------
-----------------------HMEEE-ASRLAQNEEEMKV--E-GVQ--HLSPLPSG-
EAAGAARYGVAAHSR-DPSPPGT-----CGVGRQEQGR----------------------
--LAVY-------SDHCLPVSEDF--HNSVEPAV-------GEARE--GSPRDNPTAQ-K
ILQLL---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------GC
HSPGDSRNQE-------L------------------------------------------
--------------------EVALD-------SSSTT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LYENIESLK--Q
QKKQVEHQ------LEEEKKAN---------NE--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKHAARHFE---------------------------
-----EESKDLAGHLQYSLQRIQELERALSAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCGEAVLQRQ--------LQQTRKE-QALLNAHVT---------QVTESLKQVQLQ
RDEYAQ-HIKGERAWWQERMQ--KMLM------------------EA-HAL---REEKK-
--------------------------------------------HDIHRIQELE-RSLSE
I---------KHQ-IAEPPSPV----DPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGQLQFQ-------------MENN--QALSLLSKEQK------ERLQEQKERL
REQQE--RLQEQEERLQEQEERRLREEERLCEQKERLQEKQKRLGEQGERLGKQEDRLRK
QEERLRK----------------------------EEERLQKQEERLLLSQNHKFDKQLA
EPQCDLENL--------------------------------NNKNKSALLLEQQVNELQE
KLSE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAANQEN-QQLETQFSLM--ALPGEGDGGGH-----
------------------------LDTEEEGVPRPM-PSIPED----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------MSSFMDLPKE
KVDGKEQVENL---------ELGFIQLSGATDGMREYITVYGSQGAVPNRR---------
-----------------------HQEE-EVNSLDQNEEEMNV--K-LLELQELVLPLVG-
DHEGHDKFLPAAQNP-VDEP-AP-----GAPAPQELGA----------------------
--AHEQ-------GDFYE---VSL--ADSVEPAP-------GEARE--GSPHDNPTAQ-K
ILQLL---PVMQDTQ---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PH-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GSSPEKT-----------TASDC
QSPEDIQDIL--KVLVSDLNRSNGVSLPPLDKRKAPTDCAAPAPP-------TADDDTMF
L--GVVPSPDAD---LT-----SMASPQSHDAGNCSNLMEETKTFSSTESLRQL--SQQL
NGLVSETTSYINGEGLVS-SNMKELE----------------------------------
---------------------------SRYQELAGALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDA------LK
LELYKNNKN--NEDLRQQNSELEEKLRISVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSEASDSNQQ--------LQHA-MEERAQLETHVG---------QLMESLKQLQME
RDQYAE-TLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRESQVQELE------
--ASL--AELRSQ-TEEPPPPQ----PPAGPSEV------------EERLQG---EVEQL
QKELEKLTGQLRAQ-------------VQDN--ESLSLLNRE-------------QEERL
LELERAAERWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
LHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
EIARQELQK----------TQERLEATSQEN-QQLQAQLSLL--AIPGEGDVEEE-----
---------------------------EEEAAPQPS-LTIPED----------------L
DSKEAMVAFFNT--AIASAEEKQA--------QLRMQLKEQKARCRSLAP-LAAPVQSKL
EKEAV----------VPRSV-----NDSVSEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIN
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNDWQSKFLAVSQSP-ADVP-TP-----VPTGSQEFGAV-EQ------------------
------------QGDLRE---VSL--ADSVETTQ-------GDAGA--PAPPENHTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MQ-----------------------------------
------------------------------------N-DCTTI-SRML-TQNHELKEQLS
ELRNGLVKLTNE---NMEITSH------------V-----KRELGK-------KLGK---
---------LKETMELKSQEQQQDQYL------------SHLQ--QYMATCQQLTSEKEG
LHNQLLLWTQLADQLQQQEAQSKAV----------------------------------A
KMACQELWE--------IQE--CLEAFSQQN-QQPQAQLSLM--ALPGEGDGLDSEEEV-
------------------------------EVPQPM-PSILED----------------L
ESQKAMGAFF--NSAVASAEEEQR--------MA---------------H-LLALAQKEP
EVAAP----------APGTG-----GDSMCGETHWALQVAMER--L------RFMELMQE
KVDLKERGRILPAAIPLSSRSYSCFMRCRTSRSTQAWAAAFAFL-------------FCT
R-----L--------------------------LRTMR----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MA---EET-------------------
--RQSK--------------------------LAAAKKK-------FKEY----------
WQRNR----PGVP-----AAAKRNR-------KAN--GSSPETA-----------ASGGC
HSSEA-----------SSSASSS---------------------------------LHAP
-------------QSPCQEQAAVLD-------SRSIK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNDTIKSLK--Q
QKKQVEHYSV--FLFLQEKKAN--------------NERQKA-ERELEVSGGCHLLG-FS
PKGSN--------PEIEHREKETKYGPSFEPHL---------------------------
-----NSSKDLAVRLQRSSQHIGELEWSLCAVAATPKKKPD-------------------
-----------------------------------------------------------G
--FSSRSKALLKWQ--------LEQSIRE-QILLKGHMT---------QKSS-WRE----
----------INMAQWQQRMR--KMSQ------------------EV-CTL---KTEKE-
--------------------------------------------HYTHRGEELE-MSLSK
L---------KNQ-TAEPLPPD----PAAVSSEV-------------E--------LQDL
RKELGRVAGELQAQ-------------VENN--QRISLLNRGQK------ESLHEQE---
----E-R--------------------------------------------------LR-
-----------------------------------------EQEKRL---------QQLA
EPQNDLEEL--------------------------------KNENKSALQLEQQVKELQE
KLGQV-------TEMLTSAE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------ASGTG-----DES-----------------S------GLMDLLEE
KADLREHVDKL----------------------------------ELGFIQYRR--ERCH
Q-KVHRLLTEPGDSAKDAAPGGGHHQAG----PGQGGEEGEA--A-GAAGDGVAA-YGN-
YSEGHGKFLAAARNP-AAEP-SP-----GAPAPQEL------------------------
GAADKH-------GDLCE---VSL--TNSVEPAQ-------GEARE--GSSQDNPTAQ-P
IVQLFG---EMQDHQEHPG-LGSNCCVPCFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLPP----HPA-----MAGEIR
ES----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----AGAKKNG-------KTN--GSVPETA-----------TSGGC
HSPG--DSAT-GILGDSPISFAP---------------------------------LKEL
-------------ESPCQELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELQVQIQTLNVQ---
KGKLS--------TDLFH------AKRSLRYFE---------------------------
-----EESKDLADRLQCSSQRKGELEQVLSAVTATQKKKAN----PQ-------------
------------------------------------------------------------
--SSSHRKARMEWK--------LEWSIQE-QALLKAQLT---------QLKESLKEAHLE
RDEYVQ-HLKGERARWQQRMK--KMSQ------------------EV-YTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNR-MAKPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQTLK------ERLQ------
-E----------------------------------------------------------
------------------------------------------QEEKL---------QQLP
EPQSSVEEL--------------------------------NNENKSTLHLEQQIEELQG
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAARQQN-QQLQDQLSLM--ALPGEGDGGEH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGLMDL--LE---------------------------------------E-Q--
------------------------------------------------------------
-TDLRERVEKL----------------------------------EVQFIHYWR--ERCH
Q-KIRHLINEPGGSVKDVAR-GGHHQAG----PGQGGDEGEA--A-GAAGDDVAA-YAD-
QNNEHSKLLTSSQNP-VEEP-GP-----GAPAPQE-T-----------------------
GDAHKH-------GDLCD---MSL--TDSQEPAH--------EATE--GSPHNNPAAQ-T
ITQEH---------QEHPG-LGSSRSVPFFCWAWLPRRKR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MA-----EETP--
QN----RLAA-------------------AKK-------------KLKEY----------
WQRNS----PAVP-----GEAKSNR-------KTN--GSNPETS-----------TSDGC
HSPG--DE----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-KRQLEAQIQRLNIQ---
KRKLT--------IDLYH------TKRSLMYFE---------------------------
-----EESKDLAARLQRSSQCTGELQRALSAVAATQKKKKA-------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------D------------------RV-CTL---KKEKQ-
--------------------------------------------HDMHRVEKLE-RSLSQ
L---------KNQ-RSEPLHPE----PLAVPSEV-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHLSLLNQAQK------ERLRRQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------KQEERI---------QQLA
VPQSGVEEL--------------------------------NNENKSALHLEQQVEELQE
KLREV--------ETVTSTQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GES-----------------------SGLMDLLEE
KADLRERVEKL----------------------------------ELRFVQYWRE-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------M--GG-PV--------------LGHW
WHSGG-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------ISLAVPSLP--P
HGNSSVFL------FLQEKKAN---------NE--IHEAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKCAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALSALSTQQQEED--------------------
-----------------------------------------------------------W
--SSSRSEAVLQRQ--------LQQTRKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
R---------KHQ-MAEPPSPV----DPAGTSEV-------------DQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEERL
QEQQE--R-------LQEQEERRLREEERLCEQKKRLREKQKRLGEQGERLRKQEERLRK
EEERLQKQE--------------ERLWEKEERLRKQEKRLRIQEERLALSQNHKFNKQLA
EPQCSFEDL--------------------------------NNENKSTLQLEQQVKELQE
KLSE----EFL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLEAQLSLM--ALPGQEDEGGH-----
------------------------LDGEEEEVPQLM-PSIPKG----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPRE
KVDGKQQVEKL---------ELGFFQLSGATDGMREHITVYESQRAGPNTR---------
-----------------------HQEE-EASRLAQNEEEMKV--K-LLELQDMVLPVVG-
DHEGHDKFLPAAQNP-VNEP-AP-----GAPAPQELGA----------------------
--AEEQ-------GDFQ----------DSVEPAP-------GQARE--GSPRDNPTAL-K
ILQLL---PVTQDTQEHPG-LATKPCVPFFYRAAKNREINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MMSKKT---QQRKLAGTKKKFPDY----------
HQWNS----AGV--GTGATDTKK-K-K-----ISN--GTNPETT-----------TSGGC
HSPEDKQQNRAQLKEENKASHQHQQ-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-TRQLEAQDHTIGILMCQ
KTELE--------TALHY------SQDTARKFEE--------------------------
------DSKDLAGRLHHSWHFAGELQRALSAMSAEHERADRYIEELTKEREA------MS
LELFRNIIT--NEELKEKNAELQEKLRLVET--EKSEIQLHIKEI--KRKLETDKIPLPQ
V-QTNTLQE---------------------------------------------------
-------------KMWRQEEELR---------------------------D---QEKLQK
HEEKMWRQEQRLRDQEQQMREQEQQ-------MREQ------------------------
--------------------------------------------------------EQQM
RKQEEQMRKQEEQMRKQEEQMRKQEEQMRKQ-----------------------------
------------------------------------------------------------
------------------------------------------------------------
----------EE---QMLKQ----------------------EE---------QMRKQEE
QMG--KQGS---------------------------------------------------
------------------------------------------------------------
-RWGSRR------------------------------SRCGS--RRTGEQMGEQEEQMRK
QEEQMGEQE-------EQMRKQEEQMRKQEEQMGEQ-EEQMRKQVERLQFKEERLWDEYE
KMQEEEEKIRGQVEKRREK---------------KERMGEQEEKMQEERCSEPCLPPSKY
PSDMS----------HPGSLEPAREAG---------------------------------
----------------------------------------------KG--YSHDN-RTAQ
Q-----I-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-MQLP---PGMKNAQERPG-LGSTSCIPFFYGGDKKKI-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPM-----MLDETQ
RS----QLAA--------------------------------AKKKLKEY----------
QQRNS----PGVP-----AGAKTKK-------KKT--GSSPETT-----------TSGGC
HPPGDK------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------Q
QKKQVEHQ------LEEEKKAN---------ND--IHKTQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQSSLQRIQELERALSAVSAQQWEED--------------------
-----------------------------------------------------------R
--VSPTNCPIP-WQ--------P-----E-REIVACPAT---------------------
------------SPSLQG-PF--PLCF------------------GQ-ART--LKEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
R---------KHQ-MAEPPSPV----DPAGTSEM-------------EQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEERL
----------------QEQEERRLREEERLCEQKKRLWEKQKRLGEQGERLRKQEERLRK
EEERLQKQE--------------ERLWEKEERLRKQEKRLRIQEERLALSQNHKFNKQLA
EPQCSFEDL--------------------------------NNENKSTLQLEQQVKELQE
KLSK----EFL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLEAQLSLM--ALPGQGDEERH-----
------------------------LDGEEEQVPQLM-PSIPKG----------------L
ESQEATVSLTFP--VP--------------------------------------------
-------------------------------------------------A------LPPS
SV----------------------------VP-PRPPLCSLEPSG---------------
------------------------------------------------------------
---------------------GV-----GRPEQGRLAV----------------------
--YSEP-------RLPLS---EDF--QDSVEPAP-------GQARE--GSPRDNPTAL-K
ILQLL---PVTQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSVPEKA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------SRSVE-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRVLEVQIQTLNIQ---
KGKLN--------TDLYH------MKRSLRYFE---------------------------
-----EKSKDLAVCLQHSLQRKGELESVLSNVMATQKKKAN-------------------
-----------------------------------------------------------Q
--LSSRSKARTEWK--------LEQSMRE-EALLKVQLT---------QLKESFQQVQLE
RDECAE-HLKGERARWQQRMR--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEKLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKKN--QRISLLNQRQE------ERIQEQEERL
RKQEE-R--------------------------------------------------IQ-
-----------------------------------------EQHKSL---------QQLA
KPQSVFEEP--------------------------------NNENKNALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPRPM-PSVPED----------------P
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKK----------------------------------ELCFIHHWR--DRCH
Q-KTHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPLLCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------MLPV----DVN-----ERKS--
EG--------------------------------------------LDTE----------
GKRIS----PCAL-----SCSQQQK-ALGGGAVTT--QASPPTSSHSGDSVPLCQLSQST
HTPA--LMIVLYLSPHSSSTSSS---------------------------------LHVP
-------------QSPCQEQAVVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLE--Q
QKKHVEHQ------LEEEKKAN--------------NEKEKT-ERELEAQIQRLNIQ---
KKKLT--------IDLYH------TKRSLIYFE---------------------------
-----EESKDLAGRLQCSSQCTEKLERALSAVTATQKKK---------------------
------------------------------------------------------------
--SSKRSKTLLKTQ--------LEQSLKE-CEQLKAHTT---------QMKESLQKVQLE
RDEYAE-RIKGKRARWQERMR--QMSQ------------------EL-WTL---KKEKQ-
--------------------------------------------HNMHRVEELE-RSLST
L---------KNQ-M---------------------------------------------
------VSAELQAQ-------------VENH--QHISLLNQAQK------ERLREQEERL
RRQEE-R--------------------------------------------------LQ-
-----------------------------------------EQQERL---------QQLA
EPQSGIEEL--------------------------------NNENKSALHLEQQVEELQQ
KLHEV-------NETVTSTH----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GES-----------------------RGLMDLLEE
KADLRERMEKL----------------------------------EHQFIQYCR--ERWH
Q-KIKHLVTEPEGSAKEATPGGGHHQAG----PGRR-NE--A--P-GAAGGAVAA-WVD-
GNKGHSKFLAAAQNP-ADEP-GP-----GAPPPQE-L-----------------------
GAADQH-------G----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------M----LPV-----DGEERK
LE----GL-----------------------D-------------T---EGPTSSATLKD
LEVRGSGRRCSGP-----AGQPSNL-L-----PQWGLGAPLPAE-----------TAHTH
PNPND--CSL-YFLTHSSSTSSL---------------------------------LHAP
-------------QNPCQEPAVILD-------LRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-KRELEVQIQRLNIQ---
KEKLN--------TDLYY------MKRSLRYFE---------------------------
-----YESKDVAGCLQHSLQRIAELEWALSAVTATQEKKE--------------------
----------------------------------------------------------IS
--TSSRGKAVIEWQ--------LEQSIRE-Q------------------LKELVKQVQLE
RDEYAQ-HIKGERAWWQQRMR--KMSPEGSSD------------PSV-CTL---KKEKK-
--------------------------------------------HDTHRVEKLE-RSLSK
LKNQRG----------KM--GL-P---PAVPSEV-------------E--------LQHL
RKEVERMAGELQAQ-------------VDNN--QRMSVLIWGQK------ERLQEQ----
------------------------------------------------------------
-------------------------------------------EERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEQQVKELQE
KLS---------------------------------------------------------
------------------------------------------------------------
--------------------EVKETVTSTPY--PRRE-----------------------
-----------------------------PEAVIPV-PV---------------------
-TGAESMRLT--------------------------------------------------
-------------------------------------------------------DLLEE
KADLREWVEKL----------------------------------ELRFIQYWK--DRRH
Q-KVHHLIMEPGGSAKDAAPGGGLHQAG----PGQGGDESEA--A-GAAG-DNDVACGD-
YNKGHSKFPATAQNP-ADEP-SL-----GAPAPQELGAADKH------------------
-------------GDLCE---VSL--TDS-------------------------------
--------------VEHPG-LGINPCVPFFCRAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------EAVLQRQ--------LQQTRKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMR--KMSM------------------EA-RTL---KEEKK-
--------------------------------------------RDIYRIQELE-RSLSE
L---------KHQ-MAEPPSSA----PPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGKLQSQ-------------VENN--QALSLLSKE----------LQKQEEKI
----------------HEQEERRLQEQERLCEQKEMLREQQKRLGEQGDRLRKQEERLQK
QEERLRKQEERLQKQEERLWEKEERLWEKEESL-------RMQEERLLLSQNYKFNKQLA
EPQCSFEDL--------------------------------NNENKSALQLEQQVKELQE
KLSE----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQWN-QQLETQLSLM--ALPGQGDGGGH-----
------------------------LDSGEEGVPRPM-PSVPQD----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSGFMDLPKE
KVDGKEQVENL---------ELGFIQLSGATDGMRECFTVYGSQGAVPNTR---------
-----------------------HQEEEDVSSL--------V--K-LLELQELVLPLVG-
DHEGHDKFLPTAQNP-ADEP-AP-----GAPAPQELGA----------------------
--AHEQ-------GDFYE---VSL--ANSMEPAP-------GEDRE--GSPHDNPTAQ-K
ILQLL---PVTQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----AGAKKKK-K-----IKN--GSSPETT-----------NSGDC
HSSED-----------------------------TPKDNAASPQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMVAPQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGLASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNVTIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QVSE------------------QV-HTL---REEKE-
--------------------------------------------RSMSRVQELE------
--TSL--TELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQV---ETEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KK-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAY-------QQLTSEREA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
DMASQELQE----------TQERLEAFSQQN-QQLRAQLSLT--ALPGEGDGLDREDDE-
----------------------------EEEAPWPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------KLRGQLKEQRVRCRRLAY-LLASAQ-EP
EAAAP----------PPGTG-----GDSVCGETHRALQKAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVND
RNEWHSRFLAVAQNP-ADEP-NP-----GTPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGS-EPAQ-------GETGE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQTRLPP----HPA-----MAEETQ
QS----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PSVP-----ARVKRNR-------KTN--GSVPETA-----------TSGGC
HSPG--DSAT-GIGGEGPTSSAP---------------------------------LKDL
-------------ESPCQELAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQTLNMQ---
KGKLS--------TDLYR------TKRSLRCFE---------------------------
-----EESKDLADRLQCSSQRKGELQRALSAVTATQKKA------DR-------------
------------------------------------------------------------
--SSSRSKARMEWQ--------LEQSIQE-QALLKAQLT---------QLKESLKQAHLE
RDEYAQ-HLKGERARWQQRMR--KMSQ------------------EV-YTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNR-MAKPLPPD----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQTLK------ERLR------
-E----------------------------------------------------------
------------------------------------------QEERF---------QQLP
EPQSGIEELV-------------------------CCPTWGNNENKSALQLEQQVEELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EVKETVTSAPS-KK-GREAALW--P-LPTGDGGEH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGLMDL------------------------------------------------
------------------------------------------------------------
----RERVEKL----------------------------------EVQ------------
--KIRHLINEPVGSAKDVAL-RGHHQAG----PAQGGDEGEA--A-GASGDGVTA-CAD-
HINEHSKLLTSSQNP-VDEP-GP-----GAPPPQE-L-----------------------
GAAHKH-------GDLCE---LSL--SVSAETGQ-------GEARE--GSPHDNPTAQ-P
IAQEH---------QEHPG-LGSNRCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSIPQTA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------SRSVE-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRVLEVQLQTLNIQ---
KEELN--------TDLYH------MKRSLRYFE---------------------------
-----EKSKDLAVRLQHSLQRKGELESVLSDVMATQKKKAN-------------------
-----------------------------------------------------------Q
--LSSPSKAGTEWK--------LEQSMRE-EALLKVQLT---------QLKESFQQVQLE
RDEYSE-HLKGERARWQQRMR--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEKLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKNN--QRISLLNQRQE------ERIREQEERL
RKQEE-R--------------------------------------------------IQ-
-----------------------------------------EQHKSL---------QQLA
KPQSVFEEP--------------------------------NNENKSTLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPQPM-PSVPED----------------P
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNAATLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESATCVNGEGPASSANLKDLE----------------------------------
------------------------------------------------------------
-----------------EKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELEGLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAVTQQN-QQLRAQLSLM--AHPGEGDGLDRVEEED
---------------------EDE-EEEAVVVPQLM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQNP-ADEP-AS-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGSVEPAQ-------GEARE--GSPHDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSIPEKA-----------TSGGC
QPPRD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------SRSVE-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NKKQKA-KRVLEVQIQTLNIQ---
KEELN--------TDLYH------MKRSLRYFE---------------------------
-----EKSKDLAVRLQHSLQRKGELESVLSNVMATQKKKAN-------------------
-----------------------------------------------------------Q
--LSSRSKARTEWK--------LEQSMRE-EALLKVQLT---------QLKESFQQVQLE
RDEYSE-HLKGERARWQQRMR--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEKLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKKN--QRISLLNQRQE------ERIQEQEERL
RKQEE-R--------------------------------------------------IQ-
-----------------------------------------EQHKSL---------QQLA
KPQSVFEEP--------------------------------NNENKNALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHG-EH-----
------------------------LDSEGEEAPQPM-PSVPED----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELVKK-----------------------------------ELCFIHHWR--DRRH
Q-KTHHLLSEPGGCAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------KEHPG-LGSNCCVPLFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MAEETRQSKLALAKR--------------------
-----------------------------------------------------------K
--SSSRSKACMERQ--------LEQSLRE-QALLKAQLT---------QIKDSLKQAHLD
RDEYVQ-HLKGERARWQQRMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------DNMRLVEKLE-RSLSK
L---------KHQ-MAEPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQAQK------ERLGRQEERL
QQLPE-A--------------------------------------------------QS-
------------------------------------------------------------
GVE----EL--------------------------------NNENKSALQSEQQVEELQE
TLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEASSHQN-QQLQDQLSLT--ALPGEGDGGEH-----
------------------------LGSAEEEAPRPM-PSLPED----------------L
ESWEAMSGCMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSAEDAAMGGGHHQAG----PAQGGDEGEA--A-GAAGDAVKA-GSD-
YNSKHSKLLTSSQNP-AHEP-SP-----GVPAP-QEP-----------------------
GAAHKH-------D----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQVPTCTPDP-CVSIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-ANEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETP
QN----RLAAA----------------KK----------------KLKEY----------
WHRNS---------------------------------PAVPAE-----------AKRNR
----------------KTNGSSP---------------------------------ETST
-------------SAGCHSARDV-S-------LGHPR-------------YSH-------
------------------------------------------------------------
------------------------------------------------CSLIFLIPR--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNVQ---
KKKLI--------IDVYR------TKRSLIYFE---------------------------
-----EESKDLAARLQRSSQRTEELERALSAVTATQKKAAD----K--------------
------------------------------------------------------------
--SSSRSETLLKTQ--------LERSLQE-RALLKAHVT---------QVKESLKLVQLQ
RDEYAE-HIKAERAQWQETMR--KMSQ------------------EL-CTL---KKEKL-
--------------------------------------------HDMHRVEELE-RSLSQ
L---------KHQ-MAEPQPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQPQK------ERLGRQEER-
------------------------------------------------------------
----------------------------------------------L---------QQLA
EPQSGVEEL--------------------------------NNENKSALYLEMQVEELQE
KLGQV-------NETGTSIQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GESV-----------------------SGETP---
-QALQEVMEKL----------------------------------E--VSESWN--RPRR
A-GVGRSLL-----RGDPIILAPERPYG----P-PG-GEGGA--A-RAAGVAVAA-GAD-
RNKGHRKFLAAAQSP-DNEP-GP-----GAPPPQE-L-----------------------
GAAHKH-------GDLCE---LSL--SDSAKTGQ-------GEATE--GSPHDNPTAQ-P
IAQEHQEHQEHQEHQEHPG-LGSNRCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETA-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNAATLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESATCVNGEGPASSANLKDLE----------------------------------
---------------------------VRGPGP---------------------------
------WP------SDPEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELEGLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAVTQQN-QQLRAQLSLM--AHPGEGDGLDREEEED
---------------------EE--EEEAVAVPQPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAAP----------APGTG-----DDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQDP-ADEP-AS-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGSVEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MVLPVVG-
DHEGHEKFLPAAQNP-VNEP-AP-----GAPAPQELAA----------------------
--AEER-------GDFQ----------DSVEPAP-------GQARE--GSPCDNPTAQ-K
ILQLL---PVMQDTQEHPG-LATKPCVPFFYRAAKNRKINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GHSPERT-----------SASDC
QSAENIQDIL--KVLVSDLNRSNGVSLPPLDKRKVPTDHTAPAPP-------STAAATMF
L--GVVPSPDAD---LI----------QSHDAGNCSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDA------LK
LELYKNGKS--NEDLRQQNSELEEKLRVLVA--EKAAAQLGAEEL--QKKLEMSELLLQQ
F-SSQSEASGSNEQ--------LQQA-MEERAQLESHVG---------QLMESLKQLQVE
RDQYAE-NLKGESAMWQQRVQ--QMAE------------------QV-HAL---KEEKE-
--------------------------------------------QRESQVQELE------
--ASL--AELRSQ-MEEPPPPE----PPTGPSEA------------EERLQG---EVEQL
QKELEGLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEGRL
LELEREAQHWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELARKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLTAYEQLTSEKEA
LHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
EMARQELQE----------AQERLKASSQEN-QQLQAQLSLL--VLPGEGDMDQEE----
---------------------------QDEEVPQPS-LTIPED----------------L
VSREAMVAFCNA--AIARAEEEQA--------RLRVQLREQKARCRSLAH-LAAPVQSKL
EKEAV----------VPRDM-----GDSVSEESNQALHVAMEKL------QNRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-ADVP-AP-----VPTGSQEFGAA-DQ------------------
------------QGDLRE---VSL--ADDTEPAQ-------GEAGV--PAPQENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MA---EET-------------------
--GQSK--------------------------LAAAKKK-------FKEY----------
WQRNR----PGVP-----AAAKRNT-------KAN--GSSPETA-----------ASGGC
HSSEA-----------SSSASSS---------------------------------LHAR
-------------QSPCQEQAAVLN-------SRSIK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNDTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEGQIQRLNTE---
KKKLN--------TDLYH------MKHSLRYFE---------------------------
-----EESKDLAGRLQRSSQRIGELEWSLCAVAATQKKKPD-------------------
-----------------------------------------------------------G
--FSSRSKALLKRQ--------LEQSIRE-QILLKGHVT---------QLKESLKEVQLE
RDQYAE-QIKGERAQWQQRMR--KMSQ------------------EV-CTL---KEEKK-
--------------------------------------------HDTHRVEELE-RSLSR
L---------KNQ-MAEPLPPD----APAVSSEV-------------E--------LQDL
RKELERVAGELQAQ-------------VENN--QCISLLNRGQK------ERLREQEERL
QEQQE-R--------------------------------------------------LR-
-----------------------------------------EREKRL---------QQLA
EPQSDLEEL--------------------------------KHENKSALQLEQQVKELQE
KLGQV-------METLTSAE----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------ASGTG-----GES-----------------S------GLMDLLEE
KADLREHVEKL----------------------------------ELGFIQYRR--ERCH
Q-KVHRLLTEPGDSAKDASPGGGHHQAG----PGQGGEEGEA--A-GAAGDGVAA-CGS-
YSEGHGKFLAAARNP-AAEP-SP-----GAPAPQEL------------------------
GAADKH-------GDLCE---ASL--TNSVEPAQ-------GEARE--GSSQDNPTAQ-P
VLQLLG---EMQDHQEHPG-LGSNCCVPCFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----KLAA-------------------AKK-------------KFKKY----------
WQKNS----PRVT-----AGAKRNR-K------TN--GSIPETA-----------TSCGC
QSPGD--SAT-AFHGEGPTSSAT---------------------------------LKDL
-------------ESPCREPAVVWD-------SRSVK-------------VNE-------
------------------------------------------------------------
------------------------------------------------LKNTIESLK--Q
QNKDLEHQ------LEEEKKEN--------------NKRRQA-EWGLEVQIHVLNVE---
KEKLQ--------TDLCR------TKGVLRHFE---------------------------
-----EESKDLAGHLQRSFQCIEELERALSAVATTQKVFT--------------------
----------------------------------------------------------IQ
--FSSRSRELSRRQ--------LQQSKEE-KARLKTQLT---------RLKELLTQVQLE
RDQYAC-QIEGERARWQQRMS--KMSQ------------------EI-NIL---KNDKR-
--------------------------------------------RYMRQVEEL----QSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKQLERVAGKLQAQ-------------VEKN--HRISLLNQVQE------ETLREQE---
----E-R--------------------------------------------------LQ-
-----------------------------------------EQQERL---------QQLA
KPQSVFEEL--------------------------------NNENKSTLRLEQQVKELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASKQN-QQLTAQLGLM--ALPGEGD---------
---------------------------GG--EPRPM-LSVPED----------------L
ESGEAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKQ----------------------------------EIRFIQYWR--ERCH
Q-KIHHLLTEPGGHAKDAALGGGDHEAG----PGQEGDEGEA--A-GAAA-DGIGSCGN-
DNNGHRKFLAAAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TTS---AQ-------GEARE--GPPCDNPTAQ-P
IVQDH---------QEHPG-LGSNGCLPFFGWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLPP----HSA-----MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----AGVKKNR-------KTN--GSSPETA-----------TSGGS
HSPG--DSAT-GIDREGPTSSAP---------------------------------LKDL
-------------ESPSQELAAVLD-------SRFVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNIIKSLV--R
VQWVSPWGPEERGWGSLEKKAN--------------NEKQKT-ERELEVQIQRLNVQ---
KKKLT--------IDVYR------TKRSLIYFE---------------------------
-----EECKDLAGRLQQTLQCIEELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--SSSHRKACMEWK--------LEWSTRE-QALLKAQLT---------QMKDSLKQAHLE
REEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTHRVEELK-RSLSK
L---------KHQ-MAKPLPPE----PPAVPAEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQPQK------ERLGRQEERL
----------------------------------------------------------R-
-----------------------------------------KQEEKL---------PQLA
EPQSGVEEL--------------------------------NNENKSALQSEQQVEELQE
TLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEASSQQS-QQLNAPLNLT--ALPGEGDGGEH-----
------------------------LGSAEEEAPQPM-PSLPED----------------L
ESWEAMSGCMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSAEDAAMGGGHHRAG----PAQGGDEGGV--C-GAAGDAITA-CAD-
HNNEHSKLLTSSQNP-AHEP-RP-----GVPDP-QEL-----------------------
GAAHKH-------GDLCE---VSL--TVSAETGQ-------GEARE--GSPHDNPTAQ-P
IAQE---------QQEHPG-LGSNLCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MSFRRSFI------------------
--------------------VPPL-HGMSEET---RQQKLARARKKLAEY----------
QQKHN----LPSS-----YIKKKK--------VKN--DSSSETT-----------ATDGC
CPPEDG-----------------------------RPL---P--------------MTLF
P--IEPPAPLT--------------------------PISIPRTFSSTESLRQL--SQHI
NNLVSEVPQKL-------------------------------------------------
---------------------------GPRRGLAVALDSSYLT--NKQLSSKVEELQ--Q
QNQELMDQ------LEKEKKEY---------QQKSMKEQGAL-REQLQVHIQTIGILVSE
KSDLH--------SALFH------TQRAIRQKE---------------------------
-----GESEDLASRLRSSWQRIGDLERTLSAVSTKQKQVDKDNKELTKERDA------LK
MELYKNNKN--NEDLKQTNSELEERLRLLVS--EKAALKHQFDEM--QKKLDFSELLLLQ
F-TTPTEAHNSSLQ--------LQQI-LEDREKLEKRVA---------E----MKRLQMD
RDHYLE-ILKGDTAMWQEKMH--EMSE------------------KM-RIL---KEEKE-
--------------------------------------------HSVTQVRELE------
--ASL--AELKSQ-IAEPRPPE----PPAGPSET------------EQQLQA---EAEQL
QKQLESLEGQLHAQ-------------LQEN--ESLSQQNLE-------------QWQRL
RVLEQQAELWGNQTEERKKILETI------------------------------------
------------------------------------ENDRATIS--RAVSQNLELKKQLA
ELQDGFIKMSND---KMEIASALHSEQHV-----------KM-------ELAKKLGQLQE
KLGELKETVELKNDEAKSLQQERDQYLLY---VQ----Q--------------LISERET
LHRELLQQTQAMDQLQQEKAQGAMV----------------------------------A
ERAHQELQE----------TQELLEAASQQN-QQLQAQLSLM--DTPGKEAGADEE----
-------------------------------AARPK-PGIPED----------------L
ESREAMVTFFSS--ALASAEEEQA--------QLHGQMREQKVR-------------CSA
LQAGP----------GPGIG-----GDIVSGETYRALQVDMEKL------QNRFVALMQE
KVDLKEQVDELEHRC---------VQLAGETETIGEYVILYQYQKAALKKQQHENEEYVR
Q-------------------------------MAREKEDMKAKML---ELQGLMMQLLNQ
RDKDHSQVLPDTHSA-AEEP-TP-----GPSALQELGAH--K------------------
------------QGDFYE---VSL--ADK-EPAQ-------KVPRR--GSGPENHTVQ-Q
IMELL---HDMQYPHDKTA-LGVNPCLPLFYRNKAKNQFKVWMA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPYLPP----HPM-----MLEESR
QN----KLAA--------------------------------AKKKLKEY----------
QQRKS----PGIP-----AGAKTKK-------KKT--DSSPETT-----------TSGGG
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEAKKTN---------NE--IHKAQME-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQHIQELERALCAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSCREAVLQRR--------LQQTIKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KNQ-MAEPPSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEEML
----------------REQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRK
QEERLRKEEERLQKQEKRLWDQEERLWKKEERL-------QKQEERLALSQNHKLDKQLA
EPQCSFEDL--------------------------------NNEKKSALQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQRN-QQLETQLSLV--ALPGEGDGGQH-----
------------------------LDSEEEEAPRPT-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGTEQVERR---------ELGFVQPSGVTDGMRESFTVYESQGAVPNTR---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
NHEGHGKFLIAAQNP-ADEP-TP-----GAPAPQELGA----------------------
--AGEQ-------DVFYE---VSL--DNNVEPAP-------GVARE--GSPHNNPTVQ-Q
IVQLS---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------IQ---
KGKLS--------TDLFH------MKRSLRYFE---------------------------
-----EESKDLADRLQCSLQRKGELERALSAVIATQKNKVD----RV----N------GN
FSLF-----------------------------------------------------TIQ
--FSSRSQALIEWQ--------LEQSIQE-KARLKASLT---------QLKESLREAHLE
RDEYVE-HLKGERARWQHRMR--KMSQ------------------EV-CTL---KKEKQ-
--------------------------------------------HDTHRVENLE-RSLSK
L---------NNR-MAKPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQAQK------EKLR------
-E----------------------------------------------------------
------------------------------------------QEETL---------QQLV
EPQSSVEEL--------------------------------NNENKSALQSEQQVEEVQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EVKETVTSK---------EPEA--AVPAPGTGGE------
------------------------------------------------------------
-----SSGCMDH--LE---------------------------------------K----
------------------------------------------------------------
-ADL--------------------------------------------REQYWR--ERCH
Q-NVHHLVTEPGASAKDAAMGGGHHQAG----PGQGGDEGEA--A-GAAGDAVAA-CGD-
YNKGHHKFLATAQNP-ADKP-GP-----GAPAPQE-L-----------------------
GAADKH-------GDLCE---MSL--TDSEEPAQ-------AEATE--GSPQDNHS----
-------------HQEHPG-LGSNRSVPFFCWAWLQRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------MAVLPLM-PSIPEE----------------L
ESWEAMVAFLNS--AVASAEEKQA--------WPRGQLKEQRVSCQCLAH-LVASVQKEP
EAAAL----------VPGTG-----GDSVCGEAHRALQGAREKL------QSHFMELMQE
KVDLKEQIEILERRC---------IQLSGETDIIRKHITLYQMLKM------WHQN----
S-------------------------------LAQDKEEMKVKLLELLELQELVLRLVGN
HNKWHGKFLAAAKNP-VDEP-AP-----GAP----LGAA-NK------------------
------------QGDLCK---MSL--AHSVEPAQ-------EEARE--GSPHDNPTAQ-Q
IMQLL---PEMQNPQEHPG-LGSNPCIPFFYHV------KITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------MQ-----------------------------------
------------------------------------N-DCTTI-SRML-TQNHELKEQLS
ELRNGLVKLTNE---NMEITSH------------V-----KRELGK-------KLGK---
---------LKETMELKSQEQQQDQYL------------SHLQ--QYMATCQQLTSEKEG
LHNQLLLWTQLADQLQQQEAQSKAV----------------------------------A
KMACQELWE--------IQE--CLEAFSQQN-QQPQAQLSLM--ALPGEGDGLDSEEEV-
------------------------------EVPQPM-PSILED----------------L
ESQKAMGAFF--NSAVASAEEEQR--------MA---------------H-LLASAQKEP
EVAAP----------APGTG-----GDSMCGETHWALQVAMER--L------RFMELMQE
KVDLKERGRILPAAIPLSSRSYSCFMRCRTSRSTQAWAAAFAFL-------------FCT
R-----L--------------------------LRTMR----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQARLPP----HPA-----MAEETR
QS----KLAA-------------------AKR-------------KLKEY----------
WQRNS----PGVP-----AGAKRNR-K------TN--GSIHETA-----------TSGGC
HSPGD--SAT-GIHGESPTSSAT---------------------------------LKDL
-------------ESPCQELAVVPD-------SRSVK-------------VSQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QNKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNIQ---
KGKLN--------TDLYH------TKRSLRYFE---------------------------
-----EESKDLAVRLQHSLQRKGELERALSAVTATQKKKAE-------------------
----------------------------------------------------------RQ
--FSSRSKARMEWK--------LEQSMRE-QALLKAQLT---------QLKESLKEVQLE
RDEYAE-HLKGERARWQQRMR--KMSQ------------------EV-CSL---KKEKK-
--------------------------------------------HDKYRVEKLE-RSLSK
L---------KHQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VEYN--QRISLLNEGQK------ERLREQEERL
QEQQE-R--------------------------------------------------LP-
-----------------------------------------EQEERL---------QQLA
EPQNSFKEL--------------------------------NNENKSVLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------KERLEAASQQK-QQLTAQLSLM--ALPGEGDGGGH-----
------------------------LDSEGEEAPRPI-PSIPQD----------------L
ESREAMSGFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVEKE----------------------------------ELGFFQYYR--ERCH
Q-KVYHPITKPGGSAKDAAPGGGHHQAG----PGQGGDEGEA--A-GAAG-DGVAAGGD-
Y-KGHSKFLVTAQNP-AHEP-SP-----GAPAPQELGA----------------------
--AHKH-------GDLCE---VSL--TDSVEPVQ-------GEARE--GSPHDNPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNR----PRVP-----AGVNRNR-K------TN--GSIPETA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------STSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NERQKA-ERVLEVQIQTLIIQ---
KEELN--------TDLYH------MERSLRYFE---------------------------
-----EESKDLAVRLQHSLQCKGELERALSAVIATEKKKAN-------------------
-----------------------------------------------------------Q
--LSSCSKAHTEWE--------LEQSLQD-QALLKAQLT---------QLKESFQQLQLE
RDECAE-HIEGERARWHQRMS--KMSQ------------------EI-CTL---KKEK--
--------------------------------------------QDMRWVEQLE-WSLSK
L---------KNQ-TAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQSQ-------------VKNN--QHISLLNRRQE------ERIREQEERL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------RQLA
KPQSVFEEL--------------------------------NNENKSTLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEVASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPQPM-PSVPED----------------P
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELLKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VTL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPLFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQTRLPP----HPA-----MAEETQ
QS----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PSVP-----ARVKRNR-------KTN--GSVPETA-----------TSGGC
HSPG--DSAT-GIGGEGPTSSAP---------------------------------LKDL
-------------ESPCQELAVVLD-------SRSVK-------------ISE-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQTLNMQ---
KGKLS--------TDLYR------TKRSLRCFE---------------------------
-----EESKDLADRLQCSLQRKGELQRALSAVTATQKKA------DR-------------
------------------------------------------------------------
--SSSHRKARMEWK--------LEQSIQE-QALLKAQLT---------QLKESLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNR-MAKPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQSQK------ERLQ------
-E----------------------------------------------------------
------------------------------------------QEERF---------QQLA
EPQSGVEEL--------------------------------NNENKSALQLEQQVEELQE
TLD---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQK-QQLTAQLRLM--ALPGEGDGGEH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGLMDL------------------------------------------------
------------------------------------------------------------
----RERVEKL----------------------------------EVQFIQYWR--ERCH
Q-KIRHLINEPVGSAKDVAL-RGHHQAG----PAQGGDEGEA--A-GASGDGVTA-CAD-
HINEHSKLLTSSQNP-ADEP-GP-----GAPPPQE-L-----------------------
GAAHKH-------GDLCE---LSL--SVSAETGQ-------GEARE--GSPHDNPTAQ-P
IAQEH---------QEHPG-LGSNRCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----ILAE-------------------AKR-------------KFKEY----------
WQRNS----PGGP-----AGAKKNR-------KTN--GSSPETA-----------TSGGW
HSPG--DSAT-GIDGEGPTSSAP---------------------------------LKDL
-------------ESLCQELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LK-TIKSLK--Q
QKKHVEHQ------LEEEKKAN--------------NEKQKT-ERELEVQIQRLNRQ---
IEKLN--------TDMYH------MERSLRYFE---------------------------
-----EESKDLSGRLQHTVQCIGELEKALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LEQSIQE-KARLRERLT---------RMRKSLKQAQLE
RDEYAQ-HLKGERGRWQQRMR--KMWQ------------------EV-CTL---KKDKK-
--------------------------------------------DDMHWVEELE-RRLST
L---------KNQ-MAEPLPLE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VQNH--QHVSLLNQAQK------ERLQEQEEKL
QKQEE-R--------------------------------------------------LR-
-----------------------------------------EQEERL---------QQLA
EPQSGVEEL--------------------------------NNENKSALQVEQQVEERQE
KVG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQS-QQLNAPWNLM--ALPGEGDGGGH-----
------------------------LDSEEEEGPRPM-LSVPED----------------L
ESWEAMSGIMDH--WE---------------------------------------E-M--
------------------------------------------------------------
-AVLSELVKKQ----------------------------------ELRFIHYWR--ERCH
Q-NVHQLIIEAGGSAEDAAMGGGHHQAG----PAQGGDEGEA--A-GAAGDAVVT-CAD-
LNNKHSKFLAAAQNP-ADEP-GP-----GAPPTHQEL-----------------------
GAADQH-------GDLCE---VSL--TDSAEPAQ-------GEAKE--GSPNDNPTAQ-P
IVQD---------HQVHPG-LGSNRSGPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----AGAKKKK-K-----IKN--GSSPETT-----------NSGDC
HSSED-----------------------------TPKDNAASLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMVAPQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGLASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNVTIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSQCEAPDANQQ--------LQQA-IEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QVSE------------------QV-HTL---REEKE-
--------------------------------------------RSMSQVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KK-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAY-------QQLTSEKEA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
DMASQELQE----------TQERLEAVSQQN-QQLRAQLSLI--ALPGEGDGLDRENEE-
----------------------------EEEAPWPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------KLRGQLKEQRVRCRHLAH-LLASAQ-EP
EAAAP----------PPGTG-----SDSVCGETHRALQEAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVND
RNEWHSRFLAAAQHP-ADEP-NP-----GAPAPQELGSA-NQ------------------
------------QGDLCE---VSL--AGS-EPAQ-------GETGE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQVPTCTPDP-CISIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREE---
--------------------------EEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
HSEWHGRFLAAAQNP-ANEP-AS-----GVPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWP----PL------------------
--------------------PPPR-PGMSEET---RQSKLAAAKKKLREY----------
QQKHS----PGVP-----AGAKKKR-K-----IKN--GSSPETT-----------TSGDC
PTPEDIQDIL--KVLVSDLNRSNGVAIPPLDKWKAPKDSADLVTS--------SADDTVS
P--GGVLSPCASPLRGT-----SMATTQNHDAENGPVPIDENTSFSSTESLRQL--SQQL
NGLVSESSPYINGEGLASPANIKKLE----------------------------------
---------------------------SRYHELSLALDSSNLT--NKQLSSKIEELK--Q
ENQETLDQ------LEKEKKEF---------EQKLAKEQGAL-REQLQVHIQTIGILVSE
KTELQ--------TALAH------TQQAARQKA---------------------------
-----GESENLASRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTKERDT------LK
LELYKNNKS--NEDLKQQKSELEEKLRLMAT--EKAAMQLGMEEL--QKKLEMSELLLQQ
F-STQ-PTPDSSQQ--------LQQA-LEERAQLETCVG---------QLQDSLRQLQAE
RDQYVA-NLKEDSTVWQHKMQ--QMNE------------------QL-NKL---RAEKE-
--------------------------------------------HSMSQVQELE------
--TSL--AELRNQ-A----------APPSGPSET------------EQRLQA---EAEQL
QKEVESLARQLQAQ-------------VKDN--ENLSLLNQE-------------QEQRL
MELERAAECWGEQAEERKQMLESM------------------------------------
------------------------------------QSDRTTIS--RALTQNRKLKEQLA
ELQNGFVRLSNE---NMEITSALHSEQHV-----------KK-------ELAKKLGQLQE
NLGELKETVEVKSQEAQDLQQQRDQYLGH---LQ----QYVAA-------YQQLAAEKEL
LHKQMVLQTQLVDQLQHEDMQGRMA----------------------------------V
ETARQELQE----------AQGRLEAANQHN-QQLQAQLTLM--AVPGEGTELDIEDE--
--------------------------DKAGEAPRPK-LSVPEE----------------L
DSREAVVEFFNS--ALASAEEEQA--------RLRRELKEQKLRCQRLAH-LVAPAQDGV
EKEAPAPGTEGDSVSAPGTG-----GDSVPVETHQALQVAMDKL------QGRFTELMQE
KVDLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLHLVGE
RNEWQGKFLA-AQNP-AGEP-TV-----APPAPQELGAAENQ------------------
-------------GGLLE---VSL--SDNVEPTQ-------GEALLGQT-LTENPTAQ-Q
IMQLL---REIQNPQERLG-LGSNPCIPFFYRADDNDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGAKRNR-K------TN--GSIPETA-----------TSGGC
QSPGD--SAT-GFHGEGPTSSAA---------------------------------LKDL
-------------EI--REPAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LE-------------------------------EVQIQRLNIQ---
KKQLN--------TDLYD------TKCSLRYFE---------------------------
------ESKDLAGCLQYSLQCIGELERALSAVTTTEEKE---------------------
----------------------------------------------------------IS
--FLSRSRAPVEWQ--------LEQSIQE-KARLK--------------LKESFQQVQLQ
RDNYAQ-QIKGERARWQQRMR--KMSQ------------------EV-YTL---KTEKE-
--------------------------------------------HYTHRVEDLE-RSLSK
L---------KNQ-MVKMG------LPPAVPSEV-------------E--------LQHL
RKELERVAVELQAQ-------------VKNN--QCISLLNWGQE------ERIREQEERL
RKQE--------------------------------------------------------
------------------------------------------------------------
---------------------------------------------ESALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQPSLM--ALPGEGHGGEH-----
------------------------LDSEGEE-------SVPED----------------L
ENREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKK----------------------------------ELCFIRHWR--ESCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGVAAYSN-
YKNGHRKFLATAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GGELK---RSA--ALG----------------------------R-P
NSWDH---------KHEPP-LQANLFLSN-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LREC----------
WQRNS----SGVP-----GGAKRNR-K------TN--GSISETA-----------NSGDC
HSPGD--SAT-GFHGEGPTSSAT---------------------------------LKDL
-------------KSPCQELAVVLD-------SKSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEYQ------LEEEKKAN--------------SKTQRA-EWQLEVQIERLNTE---
KDELH--------TDLCR------TKGVLRHFE---------------------------
-----EESKDLAGHLQCSLQCIGELERALSAVATTQKV----------------------
----------------------------------------------------------NS
--FSSRSKACMKWK--------LEHSIQE-QALLKAQLT---------QLKELPIQVQLE
KDEFAQ-HIKGERARWQQRMR--KMSQ------------------EV-CTL---KKK-K-
--------------------------------------------HDACRVEKLE-RSLSK
L---------KNQ-RAEPLPPE-P---PAVTSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKNN--QRISLLNRGQK------EMLWEQEEKL
R-----------------------------------------------------------
-----------------------------------------EQEERL---------QQLA
KPQSVFKEL--------------------------------N---KSALQLEPQVKELQK
-L----------------------------------------------------------
------------------------------------------------------------
------------------------GEVETQK-QQLTAQLSLM--ALLGEGDGGGH-----
------------------------LDSEGEEAPRPM-PSVPEA----------------L
ESWEATSGLM--------------------------------------------------
-------------------------------------------------------DLLEE
KTDLREWVEKL----------------------------------ELRFIQSWR--ERCH
H-KVHHLNTEPGGSAKDAAPGGGHHQAG----PGQKGDEGEA--A-EAAR-DDVAACGD-
YSEGHSKFLATAQNP-ADEP-SP-----GSPAPQELLA----------------------
--AHKH-------GDLCE---VNL--TDSVEPAQ-------GKARE--GSPHDSPTAQ-P
IVQDH---------QVHPG-LGSNHCVPFFCWVWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MLPVD-VNE----RKS-----EGLDTE
GN----RICPCIHGAGPT-----SCATLKDLE-------------VGGSG----------
WRCSD----QAGQ-----PSNLLPQ-------QGL--GAPLPAE-----------TAHTH
PSPN--DCSL-YLSPDSCSTSSP---------------------------------LHAP
-------------QSPCQEQAVVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLE--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNVQ---
KKKLI--------IDVYR------TKRSLIYFE---------------------------
-----EESKDLAARLQRSSQRTEELERALSAVTATQKKAAD----K--------------
------------------------------------------------------------
--SSSRSETLLKTQ--------LERSLQE-RALLKAHVT---------QVKESLKLVQLQ
RDEYAE-HIKAERAQWQETMR--KMSQ------------------EL-CTL---KKEKL-
--------------------------------------------HDMHRVEELE-RSLSQ
L---------KHQ-MAEPQPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSPLNQPQK------ERLGRQEER-
------------------------------------------------------------
----------------------------------------------L---------QQLA
EPQSGVEEL--------------------------------NNENKSALYLEMQVEELQE
KLGQV-------NETGTSTQ----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------KEP
EAAVP----------APGTG-----GESS-----------------------GLMDLLEE
KADLRERVEKL----------------------------------EHRFTQYWR--ER--
---LGGQSK-----AGGATPGGGHHQAG----PRRR-DEGGA--A-GAAGVAVAA-GAD-
RNKGHRKFLAAAQSP-DNEP-GP-----GAPPPQE-L-----------------------
GAAHKH-------GDLCE---LSL--SDSTETGQ-------GEATE--GSPHDNPTAQ-P
IAQEHQEHQEHQEHQEHPG-LGSNRCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------MEWK--------LEQSMRE-QALLKAQLT---------QLKESLKEAQIE
RDEYAQ-HLKGERARWQQRMR--KMSQ------------------EV-CLL---KKEKQ-
--------------------------------------------HDKYRVEKLE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ--------------------HMSLLNRQQE------ERIREQEDRL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------QQLA
KPQSVFEEP--------------------------------NNENKSALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASQQN-QQLTAQLSLM--ALPGKGTGDRS-----
--------------------------EEEERAPQPM-PSVPED----------------L
ESREAMSGFM--------------------------------------------------
-------------------------------------------------------DHLEE
KDAISEWEGEL----------------------------------QGCW-----------
--RVYHPITKPGGSAKD---------AG----PGQGGDEGRV--C-NISAGVGVGVGVA-
-----------VTEP-QPPR-SL-----GLPTNPR-------------------------
--LPLS-------KDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFRWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----SQYQE-------L------------------------------------------
--------------------ATALQ-------SSSMT-------------ITQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKEQLEHQ------LEEAKKAN---------NE--IHEAQTE-QLE------AINILTLE
KEDLK--------TALYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELERALCAVSTQQREED--------------------
-----------------------------------------------------------R
--SLSCSEAILQRR--------LQQTLKE-RALLNAHVT---------QVTESLKQVHLQ
REEYAH-CIKAERARWQERMR--KISL------------------ET-LLL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSG
L---------QNR-MAEPPSLA----PPAVTSVV-------------EQLQD---EAKQL
RKEVEVLEGKLQSQ-------------VKNN--QALSLLSKEQK------QRLQEQEQRL
----------------QEQEEQRAREQERLCQQKEMLREQ-------GKRLRKQEQRLRK
EEERLRKEEERLQKEEERLWVQEKRLWEKDERLQKQEERLRKWEERLALSQNHKLDKQLA
EPQRGFEDL--------------------------------NNENKSAVHLEQGVMELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQRN-QLLETQLSLM--ALPGEGDG-EH-----
------------------------LGSEEEEAPRPT-PNIPED----------------L
ESREA-------------------------------------------------------
--------------------------------------------------TSSFMDLLKE
KADGKEQVEKL---------ELEVIQPSGATDGMRESFTVYESQGAVPNTR---------
-----------------------HQQMEDVIRLARNKEEIKV--K-LLELQELVLPLVG-
NHEGHGKFLTAAQNP-ADEP-AP-----GAPAPQELGA----------------------
--AGEQ-------DDFYE---VSL--DNSVEPAP-------GAARE--GSPHDNPTAQ-Q
IVQLL---PVMQDTQ---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPM-----MLEETR
QS----QLAA--------------------------------AKKKLKEY----------
QQRNS----RGVP-----AGAKTKK-------KKT--GSNPETT-----------TSGGC
HSPGDSQNQE-------Q------------------------------------------
--------------------AVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LCENIESLK--Q
QKKQVEHQ------LEEEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQSSLQRIQELERALSALSTQQQEED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LQQTRKE-RALLNAHVT---------QVTESLKQVQLQ
RDEYAQ-HIKGERAQRQEGMR--KMSM------------------EA-HAL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
L---------KHQ-MAEPPSSA----PPAGTSEV-------------EQLQD---EAKHL
RKEVESLEGKLQSQ-------------VENN--QALTLLSKEQK------ERI-------
----------------QEQEERRLREEERLCEQKERLREKQKRLGAQGERLRKEEERLRK
EEERLQKQE--------------ERLWEKEERLRKQEKRLRMQEERLALSQNHKFNKQLA
EPQCSLEDL--------------------------------NNENKSVLQLKQQVKELQE
TLSKVKEMEHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQLSLM--ALPGQGDGGGH-----
------------------------ADSEEERVPQPM-PSVPED----------------M
ESQEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPRD
KVDGKQQVEKL---------ELGFIQLSGATEGMREHITVYESQWAGPNTR---------
-----------------------HQEE-EASRLAQNEEEMKV--K-LLELQDMVLPVVG-
DHEGHEKFLPAAQNP-LDEP-AP-----GAPAPQELGA----------------------
--VEE--------QDFQ----------DSVEPAP-------GQARE--GTPCDNPTAQ-K
ILQLL---PVVQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WHRNS----PGGP-----AGAKKNR-------KTN--GSSPETA-----------TSGGS
HSPGDTLSSV-AVGESRQRP----------------------------------------
-------------------KSSVL---------------------------GS-------
------------------------------------------------------------
------------------------------------------------L-RRVYQFE--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKT-ERELQVQIQRLNRQ---
IKKLN--------TDMNH------TKRSLRYFE---------------------------
-----EESKDLAGHLQQTLQCIEELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LERSIQE-KARLKAQLT---------QMKDSLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTRRVEELK-RSLSK
L---------KNQ-MAKPLPPE----PPAVPSDV-------------Q--------LQHL
RKELERVSAELQAH-------------LENH--QHVSLLNQPQK------ERLGRQEERF
------------------------------------------------------------
--------------------------------------------------------QQLA
EPQSG------------------------------------NNENKSALQLEQQVEELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEASSQQS-QQLNAPLNLT--ALPGEGDGGEH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMTALWH---HG---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------KLPFIEYWG--KRCH
SVRIHQLLTEAGQCLFFFGGGCRHHQVG----PAQGGDEVRVHIS-AGVGVGMWG-GGR-
QR---------ADTP-S-----------RSPAPQELV-----------------------
GCHNMHGV--------TE-----P--SASAPNWA-------GEARG--GS-APQPHCS-A
ITQE---------HQRRAR-LGQQPLGAVFLLAWLPRRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETA-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNAATLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESATCVNGEGPASSANLKDLE----------------------------------
---------------------------VRGPGP---------------------------
------WP------SDPEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELEGLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAVTQQN-QQLRAQLSLM--AHPGEGDGLDREEEED
---------------------EE--EEEAVAVPQPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAAP----------APGTG-----DDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQDP-ADEP-AS-----GAPAPQELGAA-NQ------------------
------------QGDLCE---VSL--AGSVEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPA-----MLEETR
ES----KLAA--------------------------------AKKKLKEY----------
QQRNS----PGVP-----TGVKTKK-------KNT--GRSPETT-----------TSGGC
HSPGDSRYQE-------L------------------------------------------
--------------------EVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
QKKQVEHQ------LEEEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQSSSQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
--SSNRSEAVLQRQ--------LRQTLKE-RALLNAHVT---------QVTESLKQVKLQ
RDEYAE-HIKGERARWQERMR--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
M---------KPQ-MAEPPSPA----PPAGPSDV-------------EQLQD---EAKHL
RKEVESLVEKLQSQ-------------VENN--QALNLLSKEQK------ERLQEQEERL
REQEE-RRLREQ---------------EGLCEQKERLQ-------EQGERLRKQEERLQK
QEERLRMEEERLQKQEKRLWDQEERLWEKEERLRKQEERLRMQ-ERLALSQNQKLDKQLA
EPQCGFKDL--------------------------------NNENKSALQLEQQVKELQE
KLSE----EYL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-RHLEAQLSLM--ALPGEGDEGGH-----
------------------------LDGEEEEAPQLM-PSFPKD----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADGKEQVEKL---------ELGFIQLSGAREGMREYITIYESHGAVPNTR---------
-----------------------HQED--IIRLAQKEEEMKV--K-LLELQEPVLLLMG-
HHEGHDKFLPTAQNS-AEEP-AP-----GAPAPQELGA----------------------
--VEEQ-------GGE--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------LPT----HPT-----MAEETR
QS----KLAV-------------------AKT-------------KFKEY----------
WQRKS----RRVT-----AGAKRNR-K------TN--GSIPETA-----------PFGGC
QSPGD--SAT-GFHGEGPTSSAT---------------------------------LKDL
-------------ESPCQEPAVVWD-------SRSVK-------------INQ-------
------------------------------------------------------------
------------------------------------------------LKNTIEYLK--Q
QKKELEHH------LEEEKKAN--------------NKTQRA-EWELEVQIEILNTE---
KNELH--------TDLCR------TKGVLRHFE---------------------------
-----EESKDLAGHLQCSLQCIGELERALSAVATTQKD----------------------
----------------------------------------------------------VS
--FSSCSRELSWWR--------LKKSTEE-KARLKTQLT---------RLKELLTQVQLE
RDQYAC-QIEGERARWQQRMS--KMSQ------------------EM-DTL---KKSKN-
--------------------------------------------HYTHRVEEL----QSK
L---------KNQ-MAEPLPPE-P---PALPSEV-------------E--------LQHL
RKQLERVAGELQAQ-------------VKKN--QCISLLNRVQE------ERLRKQE---
----E-R--------------------------------------------------LQ-
-----------------------------------------EQQEKL---------QQLA
KTQSVFEEL--------------------------------N---KSTLHLEQQVRELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASKQN-QQLTAQLGLM--ALPGEGAGSGL-----
------------------------HSEGG--EPRPM-PSVPED----------------L
ESGEATSSLM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKQ----------------------------------EIRFIQYWR--ERCH
Q-KTHHLLTEPGGHAKDAALGGGP-QAG----PGQGGDEGEA--A-GAAA-DGIGACGD-
DNNGHRKFLAAAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VNL--SSS---AQ-------GEARE--GPPCDNPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFGWAWQPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPHPFPP-------------------
----------------------PC-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PSGP-----AVVKKKK-K-----LKN--DGSPETS-----------TARDD
HSPEEIQDIL--KVLVSDLNRSNGVALPSLDRWQAPRDHAAPVPP-------SAAAATVS
P--GGVPSPGTT---LT-----SVASLQNYDADSEPNVMDETKTFSSTESLRQL--SQQL
NGLLSESTSYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQES---------QQKLAKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLAGRLKSSRQRVGELEKTLSAVSTQQKQVEKCNKELTEERDT------LR
LELFKNNKS--NEDLKQHNSELEERLRVLTA--ENAASQLGMEEL--QKKLEMSELLLQQ
F-SSGSASPDSDQQ--------FQQA-LEDRARLETHVG---------QLTESLKQLQLE
RDQYTE-NLKEERAMWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------RSVSQVQELE------
--SSL--ADLRSQ-MAESPAPE----PPAGPSEE------------EQRLQA---EASRL
QEELGRLTGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NVEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMDLKNQEAQALQQQREQLLSQ---LQ----QYAAAW-------QQVASEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELRE----------TQERLEATTQQN-QQLQAQLSLL--APPGEGAEEDEEDE--
----------------------------EEEAPLPD-VTIPED----------------I
DSQEAMVAFCNA--ALARAREEQV--------RLLAQLREQRAQCRRLAH-LATTSHGEP
EKEAL----------APGSA-----GDSVSAESHGALQLAMEKL------QSRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGE
RNEWQGRFLAAARSP-AEEP-TL-----GPKDAQEVGAAAAE------------------
------------QGDLLE---VSL--ADSVEPAH-------EAAGL--GPAPENPTAR-Q
IMQLL---REIQNPEERLG-LGSNPCIPFFYRADKNDEVKIMVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

MPDGTNRTEPNRTAPLLPPLRRRRDAPRGGTALLRQGRRLPRAPPARARRGARRELDAGG
AGHAGSCSPGPGRALIAGERIPPRERAGDAEVGHSAWEGAALPAAAPRRAGGPGRAERCP
RGPGGAVLRWGRCGAGRPGGDPPAVSAGPRSRTPPPWAGPESGHGGGPGRHSRPAPGEAG
RAGSGAERGGGARPASGPGVGRALGAEPGCR-PHRSARRLTW------------------
--------------------PGRGAD-MADGS---RQSKLAAAKKKLKEY----------
QQKNS----PGAT-----AGAKKKR-K-----AKE--GSRPETP-----------TNDDR
QSPENIQNIL--KVLVSDLNRSNGVAIPSLDKRKAYFDSDVATRNAD----QLAADVPVL
SNSNSLPSCASVLPAPG-----STQLTQIHEAEDRKNTLDENRSLSSTESLRQL--SEQL
NGLVAQSTSYVNGESGVSSTNIKEME----------------------------------
---------------------------K-------------------------------Q
QNQEAVNQ------LEKEKKEF---------EQKFSKEQAAL-REQLQVHIQTIGILVSE
KSELQ--------TALGH------TQQAARQKS---------------------------
-----GEAEDLAARLQSSRQRVSELERTLSSISMQQKQSEKHNKELVKERDN------LK
LELYKQSKG--SEEIKQQNSELSEKLRSVVS--ENSAMKLDVEDL--HKKLEMAELMIQQ
F-SNHTGNVDANQQ--------LQMA-LEERASLETQIT---------QLSESLHQLRAE
RDQYVE-KLKEEGSIWQQRVQ--QLSE------------------QV-HTM---AEEKE-
--------------------------------------------KHVAQIQELE------
--SNV--TELLSK-SAVKSMDV-EPSLPAGPTAA------------ELSLQE---EIKRL
QHEKEELHGQYQAQ-------------VRDN--EQLSHLNQE-------------QEERL
LELEKTVQRYNEESVDRQQILESM------------------------------------
------------------------------------QSDKATIS--RALSQNRELKEQLA
ELQNGFVKLTNE---NMEVTSALQSEQHV-----------KK-------ELAKKLGQLQE
NLGELKETLELKTQEARALQEQRDQYYGH---LQ----QYTVAY-------QQLAAEREE
LQKQYLLQTQLMDRLQHEEVQGKVT----------------------------------V
EMHLKELQQ----------TKESLEAVAKEN-KELQAQISQL--AAELDGRMLHR-LDGD
---------------------GVESEVMSEEMKNPS-FVIPEK----------------F
ESQEEMVTFLTS--AMSQVEKERE--------KMRQQLAVQKQQCRNLLQ-QIAALRQEQ
QHNI---------TLSEDST-----MDSVPVEVHEALKTAMEKL------QSRFTDLIQE
KADLKERLEELEHRC---------IQLSGETDTIGEYIALYQSQRAILKQRHQEKEEYIS
R-------------------------------LAQDKEEMKIKLL---ELQDLVMRLVKE
RNEWYSKYVAAAQSPELLAS-QN-EKALPVERRIELNATD--------------------
------------GEGLRE---VNLADEAEQDAAALHQSSFYPTDTKAAQPSQEDPTAK-Q
IMQLL---REIQNPQERSGSLLENPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLPP----HSA-----MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WQRNS----PGGP-----TGAKKNR-------KIN--GSSPETA-----------TSGGS
HSPG--DSAT-GIDGEGPTSSAP---------------------------------LKDL
-------------ESPSQELAAVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNIIKS-----
-LWVSPWGPEERGWGSLEKKAN--------------NETQKA-ERELEVQIQTLNVQ---
KGKLS--------TDLYH------TKRSLRYFE---------------------------
-----EESKDLAGRLQQTLQCIEELERALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LEQSTQE-KARLKAQLT---------QMKDSLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTHRVEELK-RSLSK
L---------KNQ-MAEPLPPE----PPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQTQK------ERLGRQEERL
----------------------------------------------------------Y-
------------------------------------------------------------
-----------------------------------------------ALHLEQQVEELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEASSQQS-QQLNAPLNLT--ALPGEGDGGGH-----
------------------------MDSEEEEGPRPM-PSVPED----------------L
ESWEAMSSFMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGCAEDAAMGGGHHQAG----PAQGGDEGEA--A-GAAGDAVTA-CAD-
HNNELSKLLTSSQNP-AHEP-GP-----GAPAP-QEL-----------------------
RAANQHNPRLPLSKDLCE---VSL--TDSAETGQ-------GEAKE--GSPSDNPTAQ-S
IVQD---------QQEHPA-LGSNLCVPFFCWAWLRRRR---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPA-----MLEETR
ER----KLAA--------------------------------AKKKLKEY----------
QQRNS----PGVP-----AGAKTKK-------KNT--GSSPETT-----------TSGGC
HSPGDSRYQE-------M------------------------------------------
--------------------EVALD-------SSSAT-------------IKQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLA--R
SSVFL---------FLQEKKAN---------KE--IHKAQTE-QLE------TMNILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EDSKDLAGRLQYSLQRIQELERSLSAVSTQQREED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LQQTRKE-RVLLNAHVR---------QVTELFKQVQLE
RDEYAQ-HIKGERARWQERMR--KMSV------------------EA-HAL---KEEKM-
--------------------------------------------RDILRIQELE-RSLSE
L---------KHQ-IAEPPSSV----PPAGPSEV-------------EQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------ERLQEQEER-
-------R---------------LQEQESLHEQKERLR-------EQGERLRKQEERLQK
QEERLRKQEGRLRK--------------QEERLRMQEERLRMQEERRAHSTSL-------
------DGL--------------------------------S-----------------E
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------DPS--GHLSTGDEGGH-----
------------------------LDSEEEEAPRLM-PNIPED----------------L
ECQEA-------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GHSPERP-----------TASDC
QSPENIQDIL--KVLVSDLNRSNGVSLPPLDKRKVPTDHIAPAPP-------IAATDTMF
L--GVAPSPDAD---LT----------QSQDAGNCSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEXLTS-SNMKELE----------------------------------
---------------------------NRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGSL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDAL------K
LELYKNSKS--NEDLRQQNSELEEKLRVLVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSSAAGGNEQ--------LQHA-MEERAQLETHVS---------QLMESLKQLQVE
RDQYAE-NLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRERQVQELE------
--TSL--AALRSQ-MEEPPPPE----PPAGPSEA------------EEQLQG---EVEQL
HKELERLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEGRL
LELEREAQRWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELARKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
IHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
ELARQELQE----------AQERLKATSQEN-QQLQAQLSLL--VLPGEGDVDQEE----
---------------------------EDEEVPQSS-LAIPED----------------L
DSREAMVAFFNA--AIARAEEEQA--------RLRVQLREQKARCRSLSH-LAAPVQSKL
EKEAV----------VPRNV-----GDSASEESSQALHAAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-GDVL-TP-----VPTGSQEFGAA-DQ------------------
------------QGDLRE---VSL--ADDIEPAQ-------GEAGV--PAPHENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-QRNS----PGGP-----AGAE-NR-------ETN--GSVPETA-----------TSGGC
HSPG--DSAA-GILGDGHTSFAP---------------------------------LKEL
-------------ESSCRELPAALD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKKTIKSLV--R
VQWGPLTP------RRQSWASR---------FQ--IQTLKXX-XXXXXXXXXXXXXX---
XGKLS--------TDLYR------VKRSLRYFE---------------------------
-----EESKDLAGHLQCSSQHRGELERALSAVTATQKKKAK----R--------------
------------------------------------------------------------
--SSSHWKAYMEWK--------LERSIRE-QALLKAQLT---------RMEESLKQAQLE
RDEYAQ-HLEGERAQWQQRMR--KMSQ------------------EV-RTL---KEERQ-
--------------------------------------------HDMRRVEELE-RSLST
L---------KNQ-MAEPLPLE----PPAVPSEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENN--QRVSLLNRGQK------ERLQEQEERL
QE----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQSDFEEL--------------------------------NNENKSALHLEQQIEELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASQQS-KQLQDQLNLM--ALPGEGTGDAQ-----
------------------------RKRREP------------------------------
QEEGGTSGLMDL--LE---------------------------------------E-Q--
------------------------------------------------------------
-TDLRERVEKL----------------------------------QVQFIRYWR--QRCH
Q-KIRHLINEPGGNVKDAARGGGHHQAG----PGLGGDEGKA--A-GASRDGVGA-CSD-
YSEGHSKLLASSQNP-ADEP-GP-----GAPVPQE-L-----------------------
GAAHKH-------GDLCE---MSL--TDSEEPAQ-------GEDTE--GSPHNNPTAQ-P
IVQEHQ------ENQEHPG-FGSKRPVLFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPYLPP----HPM-----MLQETG
EN----KLAA--------------------------------AKKKLKEY----------
QQRKS----PGVP-----AGTKTKK-------KKP--GSSPETT-----------TSGGC
HSPGDSQYQE-------L------------------------------------------
--------------------AVALE-------SSSVT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLK--Q
HKKQVEHQ------LEEAKKTN---------NE--IHKAQTE-QLE------TINILTLE
KADLK--------ITLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQYALQRIQELERALCAVSAQQQEED--------------------
-----------------------------------------------------------R
--SSSCSEAVLQRQ--------LQQTIKE-RALLNAHMT---------QLTESLKQVQLQ
RDEYAK-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------CDIHRIQELE-RSLSE
L---------KNQ-MAKPPSLA----PPAVTSVV-------------EQLQD---EAKHL
RQEVEGLEGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEEML
----------------GQHE-AQVWEQERLCEQNERLREQQKTLQEQGERLRKQEER---
----LRKEEERLQKQEKRLWDQEERL--------------QKQEERLALSQNHKLDKQLA
EPQCSFEDL--------------------------------NNENKSALQLEQQVKELQE
KLDE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQD-QQLETQLSLM--ALPGEGDGGEH-----
------------------------LDSEEEEAPQPM-PNIPED----------------L
ESWEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPKE
KADRTEQVERR---------ELGFIQPSGTTDGIRESFTIYEIQGAVPNTR---------
-----------------------HQEMEDVIRLAQKEEEMKV--K-LLELQELVLPLVG-
NHEGHGKFLIAAQNP-ADEP-AP-----GPPAPQELGA----------------------
--AGEQ-------D----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNR-K------TN--GSISETA-----------TSGGC
QSPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------STSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NERQKA-ERELEVQIQTLIIQ---
KEEVN--------TDLCH------MERSLRYFE---------------------------
-----EESKDLAVHLQYSLQCKGELERALSAVIATEKKKAN-------------------
-----------------------------------------------------------Q
--LSSRSKARTEWW--------LEQSLRD-QRLLKAQLT---------LLKKSFEKVQLQ
KDEYAA-SIKGERALWQQRMR--KMSQ------------------EV-YTL---KTEKE-
--------------------------------------------HYMHRVEELE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VKNN--QHISLLNRRQE------ERIREQEDRL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------QQLA
KPQSVFEEP--------------------------------NNENKSALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EERLEAASQQN-QQLTAQPSLM--ALPGEGHGGEH-----
------------------------LASEGEEAPQPM-PSVPED----------------L
ENREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKK----------------------------------ELHFIHHWR--ERCH
Q-KIHHVLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE------------------------EARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFRWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------M----LPV-----DGEERK
SE----GL-----------------------D-------------TEVDRGPTSSATLKD
LQVRGSGRRCSDP-----AGQPSKL-L-----PQWGLGAPLPAE-----------TAHTH
PSPND--CSL-YFLTHSSSMSSL---------------------------------LHAP
-------------QSPCQEPAVVLD-------LRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNNTIKSWS--S
VFLF-----------LQEKKSN--------------NEKQ----SQKAVQIQRLNIQ---
KEKLN--------TDLYH------MKRSLRYFE---------------------------
-----YESKDLAGCLQHSLQRIAELERALSAVTATQEKKE--------------------
----------------------------------------------------------IS
--TSSRGKAVIEWQ--------LEQSIRE-------------------------------
-----------QKAWWQQRMR--KMSPKGSSD------------PSV-CTL---EKEKK-
--------------------------------------------HDTRRVEKLE-RSLSK
LKNQRA----------EPLPLE-P---PAVPSEV-------------E--------LQHL
RKEVERMAGELQAQ-------------VDNN--QRMSVLIWGQK------DRLQEQE---
----E-R--------------------------------------------------LW-
-----------------------------------------EQEERL---------QQLA
EPQSGFEEL--------------------------------NNENKSALQLEHQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EVKETVTSIPH--PRRA-----------------------
-----------------------------GKRA----P----------------------
-ASGEGRGFM--------------------------------------------------
-------------------------------------------------------DLLEE
KGDLREWLEDR----------------------------------AW----QWE--LQGC
Q-RVHHLITEPGGSAKDAAPFQEPSPPRSWGRVGRQGQESLT--D-SVE-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPM-----MLDETQ
RS----QLAA--------------------------------AKKKLEEY----------
QQRNS----PAVP-----AGAKTKK-------KKT--VSSPETT-----------TSGGC
HSPGDSRNQE-------L------------------------------------------
--------------------EVAPD-------SRSTT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LYENIESLK--Q
QKKQVEHQ------LEEEKKAN---------NE--IHEAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKCAARHFE---------------------------
-----EESKDLAGRLQYSLQRIQELGRALSAVSTQQQEED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LQQTRKE-RALLNAHVT---------QVTESLKQVQLE
RDEYAQ-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
R---------KHQ-IAEPPSPV----DPAGPSEV-------------DQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEER-
---------------LQEQEERRLREEERLCEQKKRLREKQKRLGEQGERLRKQEERLRK
EEERLQKQE--------------ERLWEKEERLRKQEKRLRIQEERLALSQNHKFNKQLA
EPQCSFEDL--------------------------------NNENKSTLQLEQQVKELQE
KLSK----EFL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLETQLSLM--ALPGQGDGGGH-----
------------------------LDGEEEEVPQLM-PSIPKG----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------TSSFMDLPRE
KVDRKQQVEKL---------ELGFFQLSGATDGMREHITVYESQRAGPNTR---------
-----------------------HQEE-EASRLAQNEEEMKV--K-LLELQDMVLPVVG-
DHEGHDKFLPAAQNP-VNEP-AP-----GAPAPQELGA----------------------
--VEEQ-------SDFQ----------DSVEPAP-------GQARE--GSPRDNPTAL-K
ILQLL---PVTKDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------V-RTL---KEERQ-
--------------------------------------------HDMRQVEKLE-RRLST
L---------KNQ-MAEPLPPE----PPAVTPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENN--QRVSLLNRGQK------ERLR------
-E----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQSDFEEL--------------------------------NNENKSTLQLEQQIEELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLQDQLNLM--ALPGEGDGGGH-----
------------------------LDSE-EEGPRPM-PSVPED----------------L
ESWEAMSGLMHL--LE---------------------------------------E-K--
------------------------------------------------------------
-TDLRECVEKL----------------------------------QLQFIQYWR--ERCH
Q-KIHHLINEPGGSAKDVAL-RGHHQTG----PGQGGDESEA--A-GAAGDAVTA-CGD-
YNKGHSKLLASSQNR-ADEP-DP-----GAPPPQE-L-----------------------
GAAHKH-------GDLRE---MSL--TDSAEPAH-------REAKE--GSPHNNPTAQ-P
ITQEH---------QEHPG-LGSNRPVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----KLAL-------------------AKR-------------KLKEY----------
WQRNS----PGGP-----AEAKKNG-------KTN--GSVPKTA-----------TSGAH
THPSPNDCSL-YLSHNSSSTSSS---------------------------------LHVP
-------------QSPSQELAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEVITCL--------------A-------FLPKVQIQTLNVQ---
KGKLS--------TDLYR------TKRSLRYFE---------------------------
-----EESKDLAGRLQHSLQRKGELQRALSAVTATQKKAD--------------------
-----------------------------------------------------------R
--SSSRSKARMEWK--------LEQSLRE-QALLKAQLT---------QMKDSLKQAHLE
RDEYVQ-HLKGERARWQQRMR--KMSQ------------------EV-CTL---KKEKQ-
--------------------------------------------HHMRLVEKLE-RSLSK
L---------KNQ-MAKPLPPE----RPAVPPEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQPQK------ERLQEQEEKL
RKQEE-R--------------------------------------------------LR-
-----------------------------------------EQDEKL---------QQLA
EPQ----SG--------------------------------NNENKSALQLEQQVEELQE
TLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQK-QQLQDQLSLT--ALPGEGDGGGH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGFMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSAEDAAMGGGHHQAG----PAQGGDEGEA--A-GAAGDAVMV-GSD-
YNNKHSKLLISAQNP-AHEP-RP-----RAPAP-QEL-----------------------
GAAHKH-------GDLCE---LSL--SVSAETGQ-------GEARE--GSPHDNPTAQ-P
IAQEHQ------EHQEHPG-LGSNRCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETR
QS----ILAE-------------------AKK-------------KLKEY----------
WHRNS----PGGP-----AGAKKNR-------KTN--GSSPETA-----------ISGGS
HSPG--DVSL-GGQAPG------------------------------------------D
-------------RGPCQELAAVLD-------SRSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNIIKSLE--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNRQ---
IKKLN--------TDMNH------TKRSLRYFE---------------------------
-----EESKDLAGRLQQTLQCIEELEQALSAVPATQEEKEI-------------------
-----------------------------------------------------------S
--FSSRSQALIEWQ--------LEQSIQE-KARLKAQLT---------QMKDSLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMWQ------------------EV-CTL---KKEKK-
--------------------------------------------DDTRRVEELK-RSLSK
L---------KNQ-MAKPQPPE----PPAVPAEE-------------E--------LQHL
RKELERVSAELQAH-------------VENH--QHVSLLNQPQK------ERLQEQEEKL
REQEE-R--------------------------------------------------LR-
-----------------------------------------EQDEKL---------QQLA
EPQSGVEEL--------------------------------NNENKSALQLEQQVEELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EECLEASSQQS-QQLNAPLNLT--ALPGEGDG-GH-----
------------------------LDSEEEEGPRPM-PSVPED----------------Q
ESWEAMSGFMDH--RE---------------------------------------E-M--
------------------------------------------------------------
-ADLSELVEKP----------------------------------ELPFIEYWG--ERCH
Q-NVHQLLTEAGGSAEDAAMGGGHHQAG----PAQGGDEAPLPPG-GAAGDAIMA-CAD-
HNNEHSKLLTSSQNP-AHEP-RP-----GAPAP-QEL-----------------------
RAANQH-------GDLCE---LSL--SVSAETGQ-------GEARE--GSPHDNPTAQ-P
IHQE---------HQEHPG-LGSNRCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNR----PRVP-----AGVNRNR-K------TN--GSIPETA-----------TSGGC
QPPGD--SAT-GFHREGPTSSAT---------------------------------LKDL
-------------ESPCQERAVVLD-------STSVK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NERQKA-ERELEVQIQTLIIQ---
KEELN--------TDLYH------MERSLRYFE---------------------------
-----EESKDLAVRLQHSLQCKGELESALSAVIATEKKKAN-------------------
-----------------------------------------------------------Q
--LSSCSKAHTEWE--------LEQSLQD-QALLKAQLT---------QLKESFQQLQLE
RDECAE-HIEGERARWHQRMS--KMSQ------------------EI-CTL---KKEKQ-
--------------------------------------------QDMRRVEELE-RSLSK
L---------KNQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQSQ-------------VKNN--QHISLLNRRQE------ERIREQEERL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------RQLA
KPQSVFEEL--------------------------------NNENKSTLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EEHLEAASQQN-QQLTAQLSLM--ALPGEGHGGEH-----
------------------------LDSEGEEAPQPM-PSVPED----------------L
ESREAMSSFM--------------------------------------------------
-------------------------------------------------------DHLKE
KADLSELVKKQ----------------------------------ELRFIQYWQ--ERCH
Q-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GAAA-DGIAAYSN-
YNNGHRKFLAAAHNS-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLRE---VTL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPLFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PR-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GHSPERP-----------TASDC
QSPENIKDIL--KVLVSDLNRSNGVSLPPLDKRKVPTDHIAPAPP-------TAATDTMF
L--GVTPSPDAD---LT----------QSHDAGNCSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------NRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKKDY---------QQKLAKEQGSL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDAL------K
LELYKNSKS--NEDLRQQNSELEEKLRVLVA--EKAAAQLGVEEL--QKKLEMSELLLQQ
F-SSQSSAAGGNEQ--------LQHA-MEERAQLETHVS---------QLMESLKQLQVE
RDQYAE-NLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRERQVQELE------
--TSL--AALRSQ-MEEPPPPE----PPAGPSEA------------EEQLQG---EVEQL
HKELERLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEGRL
LELEREAQRWSEQAEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELARKLGELQE
RLGELKETVELKSQEAQGLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
IHKQLLLQTQLMDQLQHEEVQGKMA----------------------------------A
ELARQELQE----------AQERLKATSQEN-QQLQAQLSLL--VLPGEGDVDQEE----
---------------------------EDEEVPQSS-LAIPED----------------L
DSREAMVAFFNA--AIARAEEEQA--------RLRVQLKEQKARCRSLSH-LAAPVQSKL
EKEAV----------VPRNV-----DDSASEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-GDVL-TP-----VPTGSQEFGAA-DQ------------------
------------QDDLRE---VSL--ADDIEPAQ-------GEAGV--PAPHENPTAQ-Q
IMQLL---REIQNPRERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--RNS----PGVP-----AGAKRNR-K------TN--GSGPETA-----------TADGC
HSPGD--SAT-GIHGEGPTSSAS---------------------------------LKDL
-------------ESLCQELAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LNNIIKSLK--E
QKKQVQHQ------LEVVTKQ---------------TMRNKA-ERELEVQIQRLNTQ---
KGKLN--------TDLYH------MKRSPRYFE---------------------------
-----YESKDLAGRLQHSLQRIAELERALSAVTATQEKKE--------------------
----------------------------------------------------------IS
--TSSHSKAVIEWQ--------LEWSIWE-QALLNAHMT---------WLKELLKQVQLE
RDEYAQ-HIKGERAWWQQRMR--KMSQ------------------EV-CTL---KKEKK-
--------------------------------------------HDTRRVEKLE-RSLGP
Y-------CLLPF-SAEPLPLE-P---PAVPSEV-------------E--------LQHL
RKEVERMAGELQAQ-------------VDNN--QRMSVLIWGQK------ERLQEQK---
----E-R--------------------------------------------------LQ-
-----------------------------------------QQEERL---------QQLA
EPQSGFEKL--------------------------------NNENKSALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EERLETSSQQN-QPLQAQLSLM--VLPGEGDGGGH-----
------------------------LDSEEEEAPQPM-PTVPED----------------L
ESWEAMSGLM--------------------------------------------------
-------------------------------------------------------DLL-E
KVDLREWVEKL----------------------------------QLRFIQNWK--DRCH
H-SSH--YNRAGGSAKDAAPGG--HQAG----PGQGGDECEA--A-GAAG-DNAVACGD-
YNEGHGKFPATAQNP-ADEP-SP-----GTQPRRSWEQ------------GQERLTLRSD
PRLPLP-------KDLCE---VSL--TDS-------------------------------
--------------VEHPG-LGINPCVPFFCRATLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQARLPP----HPA-----MAEETR
QS----KLAA-------------------AKR-------------KLKEY----------
WQRNS----PGVP-----AGAKRNR-K------TN--GSIHETA-----------TSGGC
HSPGD--SAT-GIHGESPTSSAT---------------------------------LKDL
-------------ESPCQELAVVPD-------SRSVK-------------VSQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QNKQVEHQ------LEEEKKAN--------------NEKQKA-ERELEVQIQRLNIQ---
KGKLN--------TDLYH------TKRSLRYFE---------------------------
-----EESKDLAVRLQHSLQRKGELERALSAVTATQKKKAE-------------------
----------------------------------------------------------RQ
--FSSRSKARMEWK--------LEQSMRE-QALLKAQLT---------QLKESLKEVQLE
RDEYAE-HLKGERARWQQRMR--KMSQ------------------EV-CSL---KKEKK-
--------------------------------------------HDKYRVEKLE-RSLSK
L---------KHQ-MAEPLPPE-P---PAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VEYN--QRISLLNEGQK------ERLREQEERL
QEQQE-R--------------------------------------------------LP-
-----------------------------------------EQEERL---------QQLA
EPQNSFKEL--------------------------------NNENKSVLQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------KERLEAASQQK-QQLTAQLSLM--ALPGEGDGGGH-----
------------------------LDSEGEEAPRPI-PSIPQD----------------L
ESREAMSGFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVEKE----------------------------------ELGFFQYYR--ERCH
Q-KVYHPITKPGGSAKDAAPGGGHHQAG----PGQGGDEGEA--A-GAAG-DGVAAGGD-
Y-KGHSKFLVTAQNP-AHEP-SP-----GAPAPQELGA----------------------
--AHKH-------GDLCE---VSL--TDSVEPVQ-------GEARE--GSPHDNPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQVPTCTPDP-CVSIPRTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SGRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGEGAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQIQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLEAVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-ANEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--ASPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPPRFPP-------------------
----------------------PH-PGMSEET---RQSKLAAAKKKLREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GSSPEKT-----------TANDC
QSPEDIQDIL--KVLVSDLNRSNGVSLLPLDKRK--------------------------
---------------------------------------------------------QQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKRDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQVDKYNKDLTKERDA------LK
LELYKNNKN--NEDLRQQNSELEEKLRVLVA--EKAAAQSGVEEL--QKKLEMSELLLQQ
F-SSQSEASDSNQQ--------LQHA-MEERAQLETHVG---------QLMESLKQLQVE
RDQYAE-TLKGESAMWQQRVQ--QMAE------------------QV-HTL---KEEKE-
--------------------------------------------HRETQVQELE------
--TSL--AELRSQ-MEEPPPPQ----PPAGPSEV------------EQRLQG---EVEQL
QKELENLTGQLRAQ-------------VQDN--ESLSHLNRE-------------QEERL
LELERAAERWSEQTEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITNALQSEQHV-----------KK-------ELAKKLGELQE
RLGDLKETVELKSQEAQSLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
VHKQLLLQTQLMDQLQHEEVQSKMA----------------------------------A
EMARQELQK----------TQERLEASSQEN-QQLQAQLSLL--ALPGEGDAEQEE----
---------------------------Q-EEAPRPS-LTIPED----------------L
DSKEAMVAFFNT--AIASAEEEQA--------RLRVQLREQKARCRSLAH-LATPVQSKM
EKEAL----------VPRNV-----SDSMSEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVSE
RNEWQGKFLAVSQNP-VDVP-TP-----VPTGSQGFGAA-DQ------------------
------------HGDLRE---VSL--ADSIEPAQ-------GMAGV--PAPPENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LREY----------
QQKNS----PGVP-----AGAKKKK-K-----IKN--GCSPEKT-----------TANDC
QSPEDIQDIL--KVLVSDLNRSNGVSLPPLDKRKAPTDHTAPAPP-------TAADDTMF
L--GVVPSPDAD---LT-----SMASPQSHDAGNSSNLMEETKTFSSTESLRQL--SQQL
NGLVSESTSYINGEGLTS-SNMKELE----------------------------------
---------------------------SRYQELAVALDSSYVT--NKQLSSTIEELK--Q
QNQDTLDQ------LEKEKRDY---------QQKLAKEQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQQAARQKA---------------------------
-----GESEDLASRLQSSRQRVGELERTLSTVSTQQKQADKYNKDLTKERDA------LK
LELYKNNKN--NEDLKQQNSELEEKLRVLVA--EKAAAQSGVEDL--QKKLEMSELLLQQ
F-SSQSEASDSKQQ--------LQHA-MEERAQLETHVG---------QL----------
------------------------------------------------HTL---KEEKE-
--------------------------------------------HRESQVQELE------
--GSL--AELRSQ-MEEPPPPP----PPAGPSEV------------EQRLQG---EVEQL
QKELENLTEQLRAQ-------------VQDN--ESLSHLNRE-------------QEERL
LELERAAERWSEQTEERKQILESM------------------------------------
------------------------------------QSDRTTIS--RALSQNRELKEQLA
ELQNGFVRLTNE---NMEITSALQSEQHV-----------KK-------ELAKKLGELQE
RLGELKETVELKSQEAQSLQEQRDQCLSH---LQ----QYAAAYQQHLAAYEQLTSEKEA
VHKQLLLQTQLMDQLQHEEVQSKMA----------------------------------A
EMARQELQK----------TQESLEATSQEN-QQLQAQLSLL--ALPGEGDEEQEE----
---------------------------QEEEAPRPS-LTIPED----------------L
DSKEAMVAFFNT--AIASAEEEQT--------RLRVQLREQKARCRSLAH-LSTPVQSK-
---------------IPSNV-----SDSVSEESNQALHVAMEKL------QSRFLEVMQE
KVELKERVEELEHCC---------IQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYIS
R-------------------------------LAQDKEEMKIKLL---ELQELVLRLVNE
RNEWQGKFLAVSQNP-VDVP-TP-----VPTGSQGFGAA-DQ------------------
------------QGDLRE---VSL--ADSIEPAQ-------GAPGA--LTPPENPTAQ-Q
IMQLL---REIQNPQERPG-LGSNPCIPFFYRADENDEVKIMVV----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPHPFPP-------------------
----------------------PS-PGMSEET---RQKKLAAAKKKLREF----------
QQKNS----PGGP-----AVVKKKK-K-----LKY--DSNPETS-----------TAGDD
HSPEDIQDIL--KVLVSDLNRSNGVALPSLDRWQAPKDHAASAPP-------SA-DDTVS
P--GGVPSPGTT---LT-----SMASLQNCDADSDPNVMDETKTFSSTESLRQL--SQQL
NGLLSESASYVNGEGLTS-ANMKDLE----------------------------------
---------------------------SRYQELAVALDSSYLT--NKQLSSKIEELK--Q
QNQDTVQQ------LEKEKQEF---------QQKLSKEQVAL-REQLQVHIQTIGILVSE
KAELH--------TALAH------TQQAARQKA---------------------------
-----GECEDLATRLKSSRQRVGELEKTLSAVSTQQKQAEKYNKELTEERDT------LR
LELFKNNKV--NEDLKQHNSELEERLRILAA--ENAASQLGMEEL--QKKLEMCELLLQQ
F-SSGSASPDSDQR--------FQQA-MEDRTRLETHVG---------QLTESLKQLQLE
RDQYTE-SLK--GAIWQQRMR--QMSE------------------QV-HTL---KEEKE-
--------------------------------------------HSVSQVQELE------
--SSL--AELRSQ-MVEPAAPE----SPAGPSEE------------EQRLQA---EAERL
QKELECLAGQLQAQ-------------VQDN--ESLSRLNRE-------------QEERL
LQLEREAEVWGEQAEERRQILESM------------------------------------
------------------------------------QSDRTTIS--RAVSQNRELKEQLA
ELQDGFVRLTNE---NVEMTSALQSEQHV-----------KK-------ELAKKLGQLQE
KLAELTEMMELKSQEVQGLQQQREQLLSQ---LQ----QYAAAW-------QQVASEKEA
LHRQFLVHTQLLDQLQHEQMQGKTA----------------------------------E
DRARQELRE----------TQERLEATSQQN-RQLQAQLSLL--APPGEGEEVDEED---
---------------------------TEEEAPQPD-VTIPED----------------L
DSREAMVAFCNA--ALASAREERA--------RLLGQLREQRVQCQHLAH-LSATSHRVP
EKEVQ----------TPGST-----GDSVSGESHRALQVTMEKL------QRRFLEVMQE
KAELKERVDELEHRC---------IQLSGETDTIGEYIALYQNQRAVLKERHPN------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MR-------------------
------------------VFCINCKVTVGACS---SHEYHCSSFPPFTDY----------
HQWNS----AGV--GTGATDTKK-K-K-----INN--GTNPQTT-----------TSGGC
HSPEDSSV--FLFLQEKKASHQHQE-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------AL-RREIEAQDHTIRILMCQ
KTELE--------TALYY------SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVS
TSLIPGESKDLAGRLHHSWHFAGELQRAVSAVSTWHKKADRYIEELTKERDA------LS
LELYRNTIT--NEELKKKNAELQEKLRLAES--EKSEIQLNVKEL--KRKLERDKILLPQ
V-QTNTLQEE--------------------------------------------------
--------------MWRQ-----E-------------------------------EELRE
QEKK--------------------------------------------------------
------------------------------------------------------------
--------------------IRKQEEK---------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MW-----RQEQ---------RLRDQEG
---------KMMREQ----------------------EKMWEQEKK--------------
-----------------------------------------MQEQEEKMR---D-----Q
KMWGQEEKM-------------------------IREQKENM--Q--------------E
---------------------------------------RLPEHEERCSEPCL--PPSK-
VLCN--------------------------------------------------------
---MS----------HTGSVEPAGGEA---------------------------------
----------------------------------------------GEGS-PQDN-PTAQ
------I-------------------MQLL--------------P-GM------------
------------------------------------------------------------
------------------------------------------------------------
-----------KNAQERPG-LGSNSCIPFFYRGDKKKM-KIINI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------XXXXXXXX-------------------
----------------------XA-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPED-----------------------------TPKDNAASLQP-------S--DDTVL
P--GGVPSPGAS---LI-----SMAASQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQS--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEA
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------TQERLEAVTQQN-QQLRAQLSLM--AHPGEGDGLDREEEEE
---------------------E----EEAAEVPPPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLASAQKEP
EAAVP----------APGTG-----GDSVCGETHRALQGAMEKL------QIRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RNEWHGRFLAAAQNP-ADDP-TS-----GAPVPQELGAA-DQ------------------
------------QGDLCE---VSL--ASSVEPAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPCLPP----HPA-----MLEETR
EN----KLAA--------------------------------AKKKLKEY----------
QQRSS----PGVP-----AGVKTKK-------KNT--GRSPETT-----------TSGGC
HSPGDSRYKE-------L------------------------------------------
--------------------EVALD-------SSSAT-------------VHQ-------
------------------------------------------------------------
------------------------------------------------LNENIESLV--R
KKQV----------ETSEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFE---------------------------
-----EESKDLAGRLQSSLQRIQELERALSAVCTQQREED--------------------
-----------------------------------------------------------R
--SSNRSEAVLQRQ--------LRQTLKE-RALLNAHVT---------QVTESLKQVLLE
REEYAQ-HIKGERARWQERMR--KMSV------------------EA-HTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
I---------KPQ-MAEPPSPA----PPAWPSDV-------------EQLQD---EAKHL
RKEVESLVEKLQSQ-------------VENN--QALNLLSKEQK------ERLQEQEERL
REQEE-RREERR---------------------LQDLQ-------EQGERLRKQEERLRK
QEERLRMEEERLQKQEKRLWDQEERLWEKEERLRKQE-------ERLALSQNQKLDKQLA
EPQCGFKDL--------------------------------NNENKSTLQLEQQVKELQE
KLSE----EHL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-RHLEAQLSLM--ALPGEGDEGGH-----
------------------------LDGEEEEVPQLM-PSIPKD----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------MVSLTVPAP-
L---------------------CHLPL-----------------------W---------
-----------------------SLPD-PLMFLVPEQERL----------------ALC-
S--------------------DP-----R-------------------------------
--LPLS-------EDLCE---VSL--ADSVEPAA-------GEARK--GSPRGNPTAE-K
ILQLL---PVMQDT----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MLP------------V-----DGEERK
SE----GSDT-------------------EGD-------------RTSPYGPTSSATLKD
LEVRG----SGDP-----AGQPSNL-H---------------TQ-----------RGLGA
PLPND--CSL-YLSPNSCSTSSS---------------------------------LHAP
-------------QSLCQEPAVVRD-------SRFIK-------------INL-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLS--S
V-----FL------FLQEKKEN--------------NKRQQA-KRGLEVQIKILNTE---
KKQLH--------TDIFH------TKRSLRYFE---------------------------
-----EQSKDLAGRLQCSLQRKEELERVLSAVAATQNKKLD-------------------
-----------------------------------------------------------G
--FLSHSRAHMERM--------LQQSLRD-QALLKAQLT---------QLKETFKQGLSE
RDEYAQ-CMKGEKARWQQKMT--KMSQ------------------EV-DKL---KKENN-
--------------------------------------------HYMHWVEELE-RL-SE
L---------QKQ-TAEPLPPE-P---AAVPSEV-------------E--------LQHL
RKELERVAGELQAQ-------------VEKN--QRVSLLNRVQE------ETLQKQ----
---EE-R--------------------------------------------------LQ-
-----------------------------------------EQQERL---------QQLA
KPQSVFKEL--------------------------------N---KSTLHLEQQVKELQE
KLD---------------------------------------------------------
------------------------------------------------------------
--------------------EMKETETSTPS-KK-------------GW-----------
----------------------------------------EAG----------------T
SLWGGEISFM--------------------------------------------------
-------------------------------------------------------DHLEE
KADLSELVKKQ----------------------------------EIRSIQYWR--ERLG
G-Q--GMAGGPGGHAKDAALGGGDHEAG----PGQGGDEGEA--A-GAAA-DGIGSCGN-
DNNGHRKFLAAAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TTS---AQ-------GEARE--GPPCDNPTAQ-P
IVQDH---------QEHPG-LGSNGCLPFFGWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------PQPSLPP----HPA-----MAEETQ
HN----KLAA-------------------AKK-------------KLKEY----------
WQKNS----PRVP-----AGANRNT-K------TN--GSIPEIA-----------TCGGC
HPNDC---SL-YLSPHSCSTSSS---------------------------------LHAP
-------------QSPCQELAAVLD-------SRSAE-------------ITQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--Q
QKKQVEHQ------LEEEKKAN--------------NDRQQA-ERELQVSFLLFQHL---
L-GSN--------PDIDH------TEGRTKY-----------------------------
-----RPSKDLAVRLRHSMQCEGELERILSAVIATEKKAA--------------------
----------------------------------------------------------NQ
--LSSRSKARTEWW--------LEQSVRE-QALLKVQLT---------QLKKSFEQVQLE
KDEYAD-RIKGERALWQQRMR--KMSQ------------------EV-YTL---KTEKE-
--------------------------------------------HYTHRVEELE-RSLSE
L---------KNQ-MAEPLAPE-APTA-------------------------------AP
EEELERVAGELQAQ-------------VKNN--QHI-------K------ERIREQEERL
RKQEE-R--------------------------------------------------LQ-
-----------------------------------------EQHEKL---------QQLP
KPQSVFEEP--------------------------------NNENKSALQLEQQVKELQE
KLG---------------------------------------------------------
------------------------------------------------------------
--------------------EVKETETSTPS-KK-------------GWEAGSSL-----
------------------------L--GGEVA---------------------------V
GERGCLPSAM--------------------------------------------------
-------------------------------------------------------GA---
--------------------------------------------------------LSSR
R-KIHHLLSEPGGRAKDAALGGGHHQAG----A-QGGDEGEA--A-GDAA-DGIAASSN-
YNNGHRKFLAAAQNP-ADEP-GP-----GAPAPQELGA----------------------
--ADKH-------GDLCE---VSL--TSS---AQ-------GEARE--DPLLDKPTAQ-P
IVQDH---------QEHPG-LGSNCCVPFFCWAWLPRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MIF----LPT-----LF---D
VL----VLAA--------------------------------VLGQLKEY----------
QQRNS----PGVP-----AGAKTKK-------KKT--GGSPETT-----------TSGGC
HSPGDSRNQE-------L------------------------------------------
--------------------EVALD-------SSSAT-------------INQ-------
------------------------------------------------------------
------------------------------------------------LYENIESLK--Q
QKKQVEHQ------LEEEKKAN---------ND--IHKAQTE-QLE------TINILTLE
KADLK--------TTLYH------TKRAARHFEGGNLGTPSSFNLALRQVFRGSPLGPIS
TSVITEESKDLAGRLQYSLQRIQELERALSALSTQQQEED--------------------
-----------------------------------------------------------R
--SSSRSEAVLQRQ--------LWQTLKE-RALLNAHVT---------QVTESLKQVQLE
RDEYVQ-HIKGERARWQERMW--KMSV------------------EA-RTL---KEEKK-
--------------------------------------------RDIHRIQELE-RSLSE
R---------KHQ-MAEPPSPV----DPAGPSEV-------------EQLQD---EAKHL
RKEVESLVGKLQSQ-------------VENN--QALSLLSKEQK------QRLQEQEERL
REQQE--RLQKQEERLQEQEERRLREEERLCEQKERLQEKQKRLGEQDERLRKEEERLRK
GEERLRKEE--------------ERLRKEEERLRKQEKRLRMQEERLALSQNHKFNKQLA
EPQCSFEDL--------------------------------NNENKSTLQLEQQVKELQE
KLSK----ECL-------------------------------------------------
------------------------------------------------------------
------------------------EAASQQN-QQLEAQLSLM--ALPGQGNEGGH-----
------------------------LDGEEEEAPQLM-PSIPKG----------------L
ESQEA-------------------------------------------------------
--------------------------------------------------TSSFKDLPRE
KVDGKQQVEKL---------ELGFIQLSGATDGMREHITVYESQGAEPNTQ---------
-----------------------HQEE-EASRLAQNEEEMKV--K-LLELQDAVLPVVG-
DHEGHDKFLPAAQNP-VNEP-AP-----GAPVPQELAA----------------------
--AEEQ-------GDFQ----------DSVEPAP-------GQARE--GSPRDSPTAL-K
IVQLL---PVTQDTQEHPG-LASKPCVPFFYRAAKNREINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------LG-----ANSS--
HD----DYCS-------------------SFL-------------QLKEY----------
WQRNS----PAVP-----AEAKRSR-------KTN--GSSPETA-----------TSAGC
HSPR--DSAT-GIHRVGPTSCAT---------------------------------LKDL
-------------ESPCQEQAVVLD-------PRAIK-------------ISR-------
------------------------------------------------------------
------------------------------------------------LNNTIKSLE--Q
QKKQVEHQ------LEEEKKAN--------------NEKQKA-KRKLQVIFSSPPGN---
ISFLLFQHLLGSNPEIEH------TEKETN--Y---------------------------
-----RPSKDLAGRLQRSSQRTGELERALSAVTATQKKK---------------------
------------------------------------------------------------
--SSKRSKTLLKTQ--------LRQSLEE-RALLKAHVT---------QMKESLQQVQLQ
RDEYAG-HIKGERALWQERMR--KMSQ------------------EL-CTL---KKEKQ-
--------------------------------------------HNMHRVEELE-RSLSQ
L---------KNQ-MAEPLPLE----PPAVAPEE-------------E--------LQHL
RKELERVSAELQAQ-------------VENH--QHVSLLNQAQK------ERLREQEERL
RE----------------------------------------------------------
------------------------------------------QEERL---------QQLA
EPQKVTP-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------LFWLQSGLMDLLEE
KADLRERVEKL----------------------------------EHQFIQYWRER--CH
Q-KIKHLITKPEGSAKEATPGGGHHQAG----PRRR-DKGGA--P-GAAGDAVVA-WVD-
SNKGHSKFLAAAQNP-ADEP-GP-----GAPPPRS-L-----------------------
GL---P-------TNLCE---VSL--TDSAETGQ-------GEARK--GSPHDNPNAQ-P
IVQDH---------QEHPG-LGSNHSGPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQTRLPP----HPA-----MAEETQ
QS----KLAA-------------------AKK-------------KLKEY----------
WQRNS----PSVP-----TRVKRNR-------KTN--GSVPETA-----------TSGGC
HSPG--DSAT-GIGGEGPTSSAP---------------------------------LKDL
-------------ESPCQELAVVLD-------SRSVK-------------ISQ-------
------------------------------------------------------------
------------------------------------------------LKNTIKSLK--K
---QVEHQ------LEEKAN----------------NVKQKT-ERELEVQIQTLNMQ---
KGKLS--------TDLYH------TKRSLRCFE---------------------------
-----EESKDLADRLQCSLQRKGELEQVLSAVTTTQKKKED----R--------------
------------------------------------------------------------
--SSSHRKARMEWK--------LEWSTRE-QALLKAQLT---------QLKESLKQAHLE
RDEYAQ-HLKGERAQWQQRMR--KMSQ------------------EV-YTL---KKEKK-
--------------------------------------------DDMRRVEKLE-RSLSK
L---------KNQ-MGKMGLVP----LDSQTKQN-------------K--------TKQI
NK---------------------------------------------------------Q
KP----------------------------------------------------------
------------------------------------------SSGAQ---------LLLA
SPNCGFTAII-------------------------PPPQ--------------MVANLQT
TSD---------------------------------------------------------
------------------------------------------------------------
--------------------EEHCG-----------------------------------
--------------------------------WLTM-----------------------G
PSWQQVAAYQQL--TS---------------------------------------E-K--
------------------------------------------------------------
-EVL-----------------------------------------HRQLLQQ--------
----TQLMNQL-------QQ-----------------QEEHL--E-AASQQKQQL-TAQ-
LRLMHSKLLTSSQNP-ADEP-AW-----GCPQAWQEQG---------------VLALHSD
PRLPLS-------KDLCE---LSL--SVSAETGQ-------GEATE--GSPHDNPTAQ-P
IAQEHQ------EHQEHPG-LGSNRCVPFFCWAWLRRRRR--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------MWPQPRLP-------------------
----------------------PR-PAMSEET---RQSKLAAAKKKLREY----------
QQRNS----PGVP-----TGAKKKK-K-----IKN--GSNPETT-----------TSGGC
HSPEDIQDIL--KVLVSDLNRSNGVALPPLDKWKTPKDNADSLQP-------S--DDTVL
P--GGVPSPGAS---LT-----SMAVSQNHDADNVPNLMDETKTFSSTESLRQL--SQQL
NGLVCESTTCVNGEGPASSANLKDLE----------------------------------
---------------------------SRYQQLAVALDSSYVT--NKQLNITIEKLK--Q
QNQEITDQ------LEEEKKEC---------HQ----KQGAL-REQLQVHIQTIGILVSE
KAELQ--------TALAH------TQHAARQKE---------------------------
-----GESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDA------LR
LELYKNTQN--NEDLKQEKSELEEKLRVLVT--EKAGMQLNLEEL--QKKLEMTELLLQQ
F-SSRCEAPDANQQ--------LQQA-MEERAQLEAHLG---------QVMESVRQLQME
RDKYAE-NLKGESAMWRQRMQ--QMSE------------------QV-HTL---REEKE-
--------------------------------------------CSMSRVQELE------
--TSL--AELRNQ-MAEPPPPE----PPAGPSEV------------EQQLQA---EAEHL
RKELESLAGQLQAQ-------------VQDN--EGLSRLNRE-------------QEERL
LELERAAELWGEQAEARRQILETM------------------------------------
------------------------------------QNDRTTIS--RALSQNRELKEQLA
ELQSGFVKLTNE---NMEITSALQSEQHV-----------KR-------ELGKKLGELQE
KLSELKETVELKSQEAQSLQQQRDQYLGH---LQ----QYVAAYQQQVATYQQLTSEKEV
LHNQLLLQTQLVDQLQQQEAQGKAV----------------------------------A
EMARQELQE----------AQERLESVTQQN-QQLRSQLSLM--AHPGEGDGLDREEEEE
---------------------E---EEEVEAAPRPM-PSIPED----------------L
ESREAMVAFFNS--AVASAEEEQA--------RLRGQLKEQRVRCRRLAH-LLALAQKEP
EVAAP----------APGTG-----GDSVCGETHRALQGAMEKL------QSRFMELMQE
KADLKERVEELEHRC---------IQLSGETDTIGEYIALYQSQRAVLKERHREKEEYIS
R-------------------------------LAQDKEEMKVKLL---ELQELVLRLVGD
RSEWHGRFLAAAQNP-AHEP-AP-----GAPAPQELGAA-DQ------------------
------------QGDLCE---VSL--TGSAEAAQ-------GEARE--GSPRDNPTAQ-Q
IMQLL---REMQNPRERPG-LGSNPCIPFFYRADENDEVKITVI----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MSSCRSHI------------------
--------------------YPPP-HGMSEEN---RQQKLARARKKLAEY----------
QLKHN----LPSS-----YIKKKKE-N-----VNN--GSSSETT-----------ATDSC
CPPEDV-----------------------------SLGCGVPSRDNTESLGGHSTDDSLS
P--GSVPSPNAR---LT-----STETLKDHDVDDVSDLVDKIETFSSTESLRQL--SQHI
NSLVSESSSYVNGTGFSSSIDLKEME----------------------------------
---------------------------NRYHELAVALDSSYLT--NKQLSSKVEELQ--Q
HNQELMDQ------LEKEKKEY---------QQKSMKEQGAL-REQLQVHIQTIGILVSE
KSDLH--------SALVH------TQQAIRQKE---------------------------
-----GESEDLASRLHSSRQRIGDLERTLSAVSTKQKQVDKDNKELTKERDA------LK
MELYKNNKN--NEDLKQTNSELEEKLRFLVS--EKEALKRQFDEM--QKKLDFSELLLLQ
F-ATPTEAQNSSLQ--------LQQI-LDDREKLEKRVA---------E----MKRLQID
RDHYLA-ILKGDTAMWQEKMK--EMSE------------------KM-HIL---KEEKE-
--------------------------------------------HSVTQVRELE------
--ASL--AELKSQ-IAEPRPPE----PPAGPSET------------EQQLQA---EAEQL
QKQLESLEGQLHAQ-------------LQEN--ESLSHQNLE-------------QWQRL
RVLEQQAEMWGDQAEERKKILETM------------------------------------
------------------------------------QNDRATIS--RAVSQNLELKKQLA
ELQDGFIKLSND---KMEITSALQSEQHV-----------KM-------ELAKKLGQLQE
KLGELKETVELKNDEAKSLQQERDQYLLY---VQ----QYH------AAAYQQLVSEKET
LHRELLQQTQAVDQLQQEKVQGAMV----------------------------------A
ERARQELQE----------TQERLEAASQQN-QQLQAQLSLM--APSWEGSSL-------
------------------------------------------L----------------P
FVCKSFVTSFNS--ALASAEEEQA--------QLSGRLTEQQVR-------------CLA
LQAAA----------GPGTG-----GDVVSGETYRALQVDMEKL------QNRFVELMRE
KVDLKEQVDELEHRC---------IQLAGETETIGEYVTLYQYQRAALKKQQHENEEYVR
E-------------------------------MAREKEDMKAKML---ELQGLVMQLLNQ
HDKDHGKVLLDTHSA-AQEP-IP-----GPSALQELDAP--E------------------
------------QGDFYE---VSL--ANK-EPAE--------VAKR--GAAPENHAAQ-Q
IMELL---HQIQSPSDKTG-LGVNPCLPLFYRNKEKNHFKVWIA----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------M
GQEKWGW---------GRTG-----HSCDV--------TLLFWL------QSGFMDLPRE
KVDGKQQVENLELGF---------IQLSGATDGMREHITVYESQGAGPNTRHQEE-E-AS
R-------------------------------LAQNEEEMKVKLL---ELQDMVLPVVGD
H-EGHDKFLPAAQNP-VNEP-AS-----GAPAPQEQGD----------------------
-----------------------F--HHSMKPAP-------GQARE--GSPRDNPTAQ-K
ILQLL---PVTQDTQEHPG-LATKPCMPFFYRAAENREINIIII----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

Query Results

"ENSGT00530000062932_0"

ENSGT00530000062932_0