Query Results 

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-----------------------------------------MKQRKGQEPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKIIWKITKPP-TCVLVRVRWWGETSNGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKADHLPIGRVQING
LAQLSPTHQINGFFTIVSLTSRKLGELQVSLSLEPLSETYNSYSPHLHTDRTQN------
-----TESSSNQFLVPSGS---HGIPTVKADGKELAANGS-RSSTP---RKKDHLYFAEN
SDTIKDSFFGPQYRLNSGQSLE-----SVTVKAKAP-HKQIALFNRTECQPQIRTAAQSH
SDSCVLSSDNPPTKDLLSALLEQGNKLRNAMVVSAMKSSPDASML-LDKVHPSVKEDSLT
S---------------------SAQNQLKDHIEDQVLSATE-HTFRKHDIKTDTRAIQLL
LGSTELCKDHCWDGLGSPPDSPSPGSDVYCSSEPNDPQYDQSLLENLFYTA-PKSDNSIS
DFLSEDEDIIPAKKMNQAKALGRSSKVLEPKDHKLMKG--------TASQKTKNL-----
AEQQLLLEIPEDAQVMTLNVDRLALLGRTHSVRIIIETMGVPVESPEM-TSDKKNSTGKP
LKPTI--------GKKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDG-MVKFQ
QRSVFPVQFGGLMIQHWWNSNLTFQIYAKKTPQKKPEVIGSALFPLRAVIQSELLSFTDQ
LPVQQENG---QTALGPLKVTMELVRDNKDFIGINTKLT-SNTQHTPPCAATSPEKILQE
SKQDTTC---------TKNPQNLKQIHEETTRKAQNFVLPSPKSPISVATSSS-AFMTMP
TSHSLVNQTNESTTENALLLHVLLMVPDGKDFITGESQKQPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1083)

CNIYLICKFFSTEEVTRS
VTAWSTTQPVFNFSQ---VIPISLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LH

ENSGT00510000048072_0_Linker_1_2 (1083, 1400)

QFYVSFKDPKISRLLLDAKYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEDGTP-PPSGPRPAHFLDQPS-AASVAMAEDQGNGLMEHHFEFRVEMVKGLTPL-
--QATVWGEADCYVQYYFPFQDSQSSVLRESEFLENGITVKAFRTATTLCIPDPIFNSEH
HHTLLLPTEVPVQRLLLSAFSAHSLMPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTR----HHEDVGIQTFNLPLTPRFENSKELRS-QSSGLLDVGI
RYRRNLRTAEGALATRTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAARALAEQEPALQFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEITF-AI
YHENTKSVSDVASIQSCKEYLL-GVVKVPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1868)

VLLPENTGLLHGLE
LMQKVVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLKDPVKTDEE---E---L
ATVTISTPRLWLPLHCVLLAGHKHIHKNTYCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGSES-MERPHQTDSWIGSAYVDLARL
GEKSTRTLTVSGVYPLFGRNASNLSGAALRVHVVL-SL---SPHTEPTHE-LDSVDCSSH
SESEQIHRGN-HEMQLSPPC---GHQKSPASTQVPCTSTTAEVCLA-Q--ESPAMSDD-T
FAVSILV

PF00168 // ENSGT00510000048072_0_Domain_3 (1868, 1974)

ERAMHLSLKGIPLTERKVTVPSCCVSFATA-VESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLIHFKEERQARRGMETQAS-LIPVYSP---FSFPASDMYAAFPSG
IARHTQDQLTHTSSKDLDFSSL-----G---KNNTIRSPASRHEEHVQNIRRFHESLQ-Q
GDTVSKSENRLNTLPLS-SSPSILTSLRKNLSELDEIQQYFSQKLNKPFVPLSPRTNPAI
LQCQENHRDQPGPEV--S-SRDL---QSQCILEKSSNLVLQVSSLISDLQTIT--KNS-Q
AALTSHRAR---SRSQKVTTLPDAQDTEAVQERSTTPD--EPSARAAEAATNSPPPLALQ
ETSNG-EGMFQESLGHTVLVSRMQS-------------------S---EETEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPDKVHRESLSSPSPEPAPR-
GALRARGSFPSSPKMAV-----------SSHLPGQSAPS--LVACEGGTSKARVG-EAA-
STNPQPSTLLQRSGTQRSSAFIGWN-SP--RTDQDKEPRLKAQADNEA------ASS---
-------------ELSDS-------------TDST-EKS--PQCLTSQRKRENREKSPVK
------------------------SPNIRQKQVITGSEV-STKQS----LLPEPIVVPNF
FLPPQQLEASLRMLSLSSALPPPVTEDQDKSEATSGAF---------SRRPCRPRPHSL-
-------PPNLSEEETRR---IARI--FASQFPKTD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------SALLDQGNKLRDAMVVSAMKSSPDMEIE-LSEVPPFVETDGFK
AAAK----------------------------ISSHHSLSD-ITSQQLDLNSEDRAIQLL
LGNADLSPVRFWDQTGSLWDSLSIGSEVY-DSELNDPHYDQSLLESLFYTA-PKSDSSLS
DFLSDED-VNPSKETGKTKTVTKADSANPQKD-----SSAFDQDQQLA------------
-PLDVHTE---EIRVASLSIDKLALLGRIHLARVIIESLRIPPES-TQVTPRKKGLMGKP
PRPAS--------VNKCTFFVEYHFPVGASKNEKGQVSVTTEVVRIASSKITDG-VVKFQ
QRFVFPVRFGGTMIEHWWSSDLAFKIYMRKSTQKKPVAVGSALLQLCKVIQSELLTVSDE
IPVEKEGD---QIQVGPLKVSLELAADNKDFTSTTARSA-AAAQQVPAHAVRSPRLEFRE
PNRNGVN---------AESCVKF-SNHEDLQKKGA-------ASTNIGW--PP-QAVSTS
GARNLMAQTPA-SEDYGLLLHVLLMVPDGKDFIAEQYGLHASCNVYLNCKLLSTEEATRS
AVIWGTTQPAFNFSQ---VMPFSLTSKHLERLKNNVMVIEAWNKMGSPGSDRLLGLVKLP
LHQFYISFKDPKISHLLLQAQYPVVAVDSYMPVIDVFTGSKSGSLRVILAMGSADQIVAL
QRLKNEEGMV-PPITRRPAHSLDPP-PPKPTMLLEREGEELMEHVFEIHVESVKGLTPL-
--QSTVWGEADCYVQYHFPVQEPGSGALQGTELHEDGIKLKPFRTATALCIPDPVFNDEH
HHSLLVPADVPVQRFLVSAFMAPGA-VGGGIQFEVWCRYRITSLREKL------------
-GNSSAFGAETAFCSAVVLS---NNTNISSGKATEEI-SATSSHQRFSIKLNPGLLDVSV
RYHRFVKT-AGI-TTQAVSLSVQIHRAAGLQAAARAVAEKNPSVQYYAGVGVNAYVSVHL
SFLPETERRNTQAVARSFCPEFEHHME--FPCNLIVQKSSGEASCLGELLQSANIIF-SV
YHQMVKSATDTLAARTSRDYLL-GTVTVPTRDLLRRR-SGITGWYPVTLAEDALPSHRTN
IMQAIGGGLELSVTFARHGDRERVLEAAKLLGWNSEESPEDSLD-----ESDEWEQSDNP
VAVTISTPRVWLPVHCVLLAGQMHLNRSTYCYLRYKLYDQEATWTSLRRPKLSEDAKNVT
VNFKKPNKVTLRRSQGLIWFFREEKLEIQVWWAYGRENDVERPLDTDRLIGSAYVDLGAL
AERSRATLSVGGVYPLFRCNAADLAGAAVRVHIALSST---SAAL--TSR-LHCAEEYSS
GEDESTEKAPDPSQQGPENH---CQNLDIVNSEISSEK--------PQE--GDVEFLENT
VA

PF00168 // ENSGT00510000048072_0_Domain_3 (1863, 1956)

VNILVERAMHLSLKGSPLTEREVTAPSSCVTFAVA-GADAPVTTSVIENTDSPVWDFQ
QQARLSKELLLDPQQTLVFKVWHKAAETERVIGFASVDLSPLLSGFQLVCGWYNITDFSG
QCRGQIKIAVSPLQNINNLKEEKQARIRTQTPNS-SLPQQVK---DSFPV------SPSN
VSSFSK-QMSNTLSKNSARCPLKQAPGPVPSRINSPKPHALRHEEHMQNVRRFHESLQ-Q
AEGNAQRAAKVDSLSLS-SRASLLTALRNNLSELDEVQRYFSQKLTRSFPDFSYGNTPRP
S-HEEQESDHQGLR---SREAHP---NGYHLLKKSSQLVSQVSNLINDLQTIT--KNS-K
DSSVGHQDN---SRKPSAARVPHQKGGKARTEVHQG----QGESDSTNSRSDTQLPCSF-
----G-RHILQELLDQAVPESKHPLPTG---------------CMRRDEGVFATQPPSEE
EYEEDVIEPRTLNEITTLTDKTSPWSSVLSEVELGAE-QQPLNVGPEDQGDADC--LQK-
-GNRRRSSSLASVPQGTEG--LKSLN-GVTEKKTGKEL----L------RSARSS-----
-E------VHQTVGGPVENGNCSWDRKF--NAEQIKQN-----AEFHA------ASEELL
EFPGVFGLTIPKTTVRK----------KENAQPSF--------V-WSHTA----------
-----K--------------------------------G-CSLTAL---LRPEPVVVPNF
FLPPQQMEASMRMLS---------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVSKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTEDVLLSKQ
GFRENTEPSSTPFLVPSRP---HDIHTIKIDGKESAANSS-RSTTL---RGKDHVYFAEN
SDTIKDSFFGLQHHLNSGQSLE-----SVTLKGKAP-WKQMSLLNSSEFQPQIRTVAKSR
SDSCISSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPTKEDSLR
AS-T------------Q-IRT-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNIWDGLGSPPDSPSPRSDVYCSSELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDTVPSENMNQSKALARSSKLLESGDHKPKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQVMTLSVDKLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKLTT--------AKKRTFFVEYHFPVGFSESRLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIDHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQENG---QTPFGPLKVTMELVTDNKDFTGVNTKLS-GNTHCTPLCAPTNPNKALPE
LNQDKTC---------TKNPQNLNQIHEETAKKAQKLVLPNRKSPSPIAPYPS-TFMAMP
ASHNLVNQTNESAIESALLLHVLLMVPDGKDFIIGESEKQPPCNVYLNCKLFSTEEATRS
VIAWGTTQPVFNFSQ---VIPVSLSSTYLERLKNNVMVIETWNKVWSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSRRPAHFLDQPT-VASVAMAEDRGNGLMEHCFEICVKMLQGLTTF-
--QATVWGEADCYVQYHFPVQHSQSSVLKGPEFPENGITLKPFRTATTLCVPDPIFNSDH
HHSLLLPAEVPVQRLLLSAFSAQGVVPGGGVQFEIWYRYYFPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---RREDVGMQTFNLPLTSMIEDRKELRN-QSSGFLDVVL
RYRRSPRTAVEVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKVLAEQEPALQFSATVGVNASVTTHL
SFLPQEKQRRTRPVACSFCPEFSHHIE--FTCNLVTQHCSGEASFLAELLEFAEVVF-AV
YHENTKSAGDIISIQSCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAEPMGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPTHCVLLAGHKHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIV
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNTS-VERPHQTDSWIGSAYVDLARL
GERSAKTLTVSGVYPLFGQNASNLSGAALRVHVVLSSL---SSHPEPTHE-LDSMDCSSY
SESEQLPRRN-NEVQFSPPEEVSCHQKSPTSTQVPCGSTTDEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQRTLVFKVWHKG-EEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFKEEKQARRGGETSGS-LIPVYSP---ISFPASDMYAALSSH
MARQTLDQLTHISSKELDFSSP-----G---RSGTTRSQASRHEEHVQNVRRFHESLH-Q
GEALLPSDDKLTTTPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTHMTI
SQHQESCRDHPGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALKSHRAR---SRSNKATTLPDAQYTEALQERCTTPD--EPLARAPDKGTDSPPPPALK
ETSYG-GRILHESLSHTVPITKMQI-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-EIISPQPDEVQREGPSCPSPGPFCR-
EELTVKNSFLSSPERAV-----------NSHLPRQGSPSQSLVACEGEASKAKVGGESA-
SASPRPLPCLTLSGAQQSSTFVGWS-SP--QVDQNKEPKSEAPVENEP------ATS---
-------------ELRDS-------------ADSF-KKL--PVNLASQSRRENHKGPPIN
------------------------SSDIRQRQMTTGSEM-STKRSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATTGAL---------SHRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKSQGPGGGRSRRK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKITKPP-ASVLVRVRWWGETSDGT
LFCPRDALQTEPKVVRTTTRYAIRCGPKQFTSYLTXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXVSLALEPLSETYDSYSPLPTTDMTDNLLLTEQ
GFRENTEPNNIQFLVSPK---PQRIPTAKIGGKELAANSS-RSTTP---KGKDHLYFAET
SDTVKDPFFGLQHHPDSEQNSD-----SMTLKSKAP-RKQMSLLNSTDLQSQIKTVSKSH
SESCILSSNNPPTKDLLSALLEQGNKLRNAMVISTMKSTPDTSML-LDEVDLPMKKDFLT
EST-------------Q-IKA-LSRDKLKDHTEGHFLSPTE-NAFWKHDTNTDAGAIQLL
LGXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXKSESSVS
DFYSEEDDNVTSKKLKQSNAPDRYPKVLESRDHKLKNT---------AGKRSRNL-----
IEQQIQSETPEETQRVTLSPDRLALLGRTHSVRIIIETMGVPPQSPQV-TLGQKNFPGRP
SKLTP--------AKKRTFFVKYHFPVGFSKSGVGKTALVTEVVRLASSKITDG-MVKFQ
HRSVFPVQFDGPMIEYWWNSSLVFQIYAKNAPQKKPEVIGSASLPLRAVIQSELLSFNKL
LPVQQEDC---QSSLGPLKVTVELVLDNKDFAGVTAKHN-SKTHHTLLGALLSPDKTLLE
SSQLASR---------IRNPQKPEQIHEDIANKAQNLALADPKSPRPVVPNLSADFVNVP
TSHNVVNQTNGSSKKNALLLHVLLMVPDGKDFITGDSEKQPPCNIYLNCKLFSTEEVAKS
AIAWGTTQPVFNFSQ---VIPVSLSSKYLERFKNNVMIIETWNKVRRPGQDKLLGLVKLP
LHQFYMSFKDPQISHILLDAQYPVVAVDSSMPVIDVFSGQQNGSLRVFLAMGSAEQIMAL
QRLKNEEEVR-PPFGCSSAHISNPPS-AASVATVEEQGNVLADHHFELHIEKVKGLALL-
--QATVWGEADCYVQYYFPVQDSQSSVVKEPELLEKGITVKPFRSATTLCVPDPIFTSEH
HHSLLLPAEVAVQRLLLSVFSAQGV--PGGVQFEVWYRYYYPTVKDQM------------
-VAKGTLPL-SRICAMVTTQ---HHEDVGIQTFSLPLTPRLESRKELRN-QSSGLLDVGL
RYRRTLRTAEGVLAARTVSISVQIIRACGLQAAAKALAEQEPALQFSAAVGVNAFVTTHL
SFLPKGELRQTRPVACSFCPEFSHHIE--FPCQVVTQHSSGEACFLAELLEFAEVTF-AI
YHENTKSVGNITSINLFKDYLL-GIVKVPTKELLVKR-SGIIGWYPIILPEDGTLPHSLD
LMQKIVGGLELSISFTHPGDREWVLEAAELLGWSYE----DKLKDLTKMNKN---E---P
AIITISTPRLWLPTHCVLLAGQTHIHKSTHCYLRYKLYDHDGFWTPLKKPKECTNKKLVM
VTFKTSKRAEVTRSPSLLWYFREERLEVQVWRAYGNDS-VERPHQTDTWIGSAYVDLARL
GERSSETLTVSGVYPLFGRNASNLSGAAVRVHVVLSSQ---APHLGPVPE-GDSMDCSSH
SESEQLPRTS-TEIQLSPPR---S-SKSSASIQVPSNSNATEVDP-----EEPAKQEG-T
FT

PF00168 // ENSGT00510000048072_0_Domain_3 (1863, 1956)

VSILVERAMHLSLKGSPLTKRKVSVPSCRVSFVTA-EEPSPVYTHVVENTDSPIWNFQ
QQSXXXXXXXXXXXXNMVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
DCQGQIKVAVSPLENLMHFKEERQARRGVETPGS-RIPIYSS---FSFPASDML---PSS
FVSQAPEPFAQTSSKEFDFSST-----G---RSGITRTQASRHEEHVQNIRRFHESLQ-Q
GETALPSDNGLVSSP---SRPSILTSLRKNLSELDQIQRYFSQKLTKPLPPFSPQSHSSS
LQCQESQRHQLGPR--TS-SLDP---ESQCILEKSNNLVLQVSSLITGNF----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLSSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTVFGPLKVTMELVTDNKDITGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKQLRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLAKAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPQPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKAQGPGGGRSRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLSVNKVIWKIAKPP-ACVLVRVRWWGETSEGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLEHLPVGRVQISG
LAQLSPTHHIDGFFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTT---ENVLLSEQ
GFRECSEASNTQFLVPSR------IPTTKTDGKDLAANSS-RSTPP---RGKDHLYFAEN
SDTIKDSFCGLQHHLNSGQSLE-----SVTLKGKAP-WKQMSLLNSSEFQPQISTVAKSH
SDSCVLSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LEEVHPSMKEDFLR
ASS-------------Q-IKA-LSRNQDKDHIEDHLLPPTEK-----HDTKADTRAIQLL
LGSAELSQGRYWDGLGSPPDSPSPGSDVYCSSEPSDPQYDQSLLENLFYTA-PKSDTSIS
DIFSEDD-DVPSKTMSQSKALARSPKVLESNDHKSK----------KMGKKNRNL-----
VEQQMLSKTPEDAQVMTLSVDKLALLGRTHSARIIIETMGVPPDSPQD-TSGKKTFPGRP
PKLT---------SKKRTFFVEYHFPVGFSKNGLTKTTLITEVVRLASSKIIDG-VVKFQ
QRSVFPVQFGGPMIKHWWNSNLTFQIYTKKAPQKKPEVIGSASLPLRTVIQSELLSFSDQ
LPVQQENG---QTPLGPIKVTVELVLDNKDFTGVNTELS-SNTQHTPFSALTNPDKTLPE
TVQDVTC---------TKNPQTLNQTYEETVKKMQNLMLPTPKSPSPFIPNSS-TFMAAP
ASHDLVNEMNGSTEESALLLHVLLMVPDGKDFVSGESEK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSSNVYLNCKLFSTEEVTRS
VIAWGTTKPVFNFSQ---VIPVSLSSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKVSRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-TPFNPRPAHFLDQPS-VASVAMAGDHGNGLMEHHFELLVDKVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSNVLKGPEFLENGITLKPFRSAATLCVPDPVFNSGH
HHSLLLPAEVPVQRLLLSAFSAHGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDGGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRQTRPVACSFCPEFSHHSE--FSCNLVTQHCSGEACFLAELLEFAEVTF-AV
YHEDTKSASDITSIHSFKDYLL-GVVKIPTKDLLMKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1864)

IVFPEEGVLPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAKLLGWSFE----NNLKDFVKMDKE---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKSTYCYLRYKLYDHEGFWTPLKKPKESTNKKQVM
VTFKASKRAEVTRSPSLLWYFREERLEIQVWRAYGNES-VERPQQTDSWIGSAYVDLTRL
GERSARTLTVSGIYPLFGRNASNLSGAALRVHVVLSSL---SPHPGPTHE-LDSMDCSSH
SESEQVPRGI-DEIQLSPPH---GHQKSPASTQIPCNNTTAEVCAA-Q--EGPPESDG-T
FTV

PF00168 // ENSGT00510000048072_0_Domain_3 (1864, 1974)

SILVERAMHLSLKGSPLTQRKVSVPSCCVSFVTA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFKEERQARREVENPGS-LIPVYSA---FSFPASAVYAAFPGR
TVGQTPELPAHPSSKEADFSSP-----G---TSGSTRSQASRHEEHVQNIRRFHESLQ-Q
AEAVLPDADRLAASPLS-SRTSILTSLRRNLSELDQMQRYFNQKLTKPLLPLSPQMHTAI
LQSQESQTDRLRPA--AS-SLDP---ESQCILEKSNNLVLQVSSLITDLQTLT--RNS-Q
GSVSSHQAR---SRSREVTALPDAQDRGTMQERSTSPD--LPLARAPDESRSSPPPSALK
ETSSG-RGKLHEALEHRIPITKMQS-------------------TEDT---EAGLAFSDE
DYEEDIIEPRTLNEITTATDKTSPWSSFMSDAS-EGRSPQPDEAQREGFSCPS-ESFPR-
EELRVRSSFLSSPERNV-----------DAHFHRQGSPSQSTVSCEGVVSKARVG-EPA-
SADPQLTSHMTLLGGQQSDTCVGWH-SP--KANQDQGPKPQSQAKKEV------ASD---
-------------ELSDS-------------ADSS-EKL--ALQPASQSRRENHKEPPIT
------------------------CPDIRQKQTTSGSEV-STRQSL---LLPEPVVVPNF
FLPPQELEASLRMLSISAALPPPATTDQDKSKATRGSL---------SQRPCRPRPSSL-
-------PPTLPEEETRR---IARI--FSSQFSQKD------------------------
-------------------------------------------------------

-----------------------------------MQQRRPR------------------
-----ASAPAPGVSRRRRGAGVRV--------------GVGEGWRSAAAP----FRSLTS
LRSAAPGDIPASTSLPPLVEGPPRCVLCCTVGRIVWTAAKPPSAAVLVRLRWWGETSDGT
VFHPSSK--PGQAAG--SSRYTVRCGPRQLTAYLTDMGMLVLEVLTKPDRLPVGRVQITE
LSQLSPSHPISGFFTIVSPTADKLGELQVSLVLEPLSDTYKTSSSGPTTATSSDM-----
------------TPAPSQQ----MQT--TPPGQEPV--NKSRVTTP--SWGKDHSFFQEN
SENIKDVSS---------ASHHRLILPDEHLKVNPLSQQSVSFPSSTDPEAPL------S
TNTHVFSLHNPTTKDLLSALLDQGNKLRDAMVASAMKSSPDMEIE-LNEVPPFVKPDGFR
-------------AAAKSPKG--LNSTFMPPPEDTHLFTSE-VTGQQLDLNSEERAIQLL
LGSADLSPVHFWDQPGSLLDSLSVGSEVY-DSELNDPHYDQSLLESLFYTT-PKSDSSTS
DFLSDED-VNPSKKVSKTKTVKKADSVNAQKD-----STASDQDQKVTEIKPSCSPTRQL
APPDVDTE---EAHVTSLSVDRLALLGRIHLARVIIESLRIPLES-SQITPRKKGLMGKP
PRPAS--------VNKCTFFVEYHFPVGASKNEKGQVSLTTELTRIASSKITDG-VVKFQ
QRFVFPVRFGGTMIEHWWSSDLAFKIYMRKSTQRKPVAIGSAVLQLCKVIQSELLTFSCE
IPVEKEGD---QMQVGPLKLSVELAADNKDFTCTTARCSVAVQQQVPPRAIRSPQMELWE
PNRDRVN---------AESCLKF-RNHVDSEKTGA-------ACTNVVQ--PP-RSVSTP
VARNLMTQLPA-AEDYGLLLHVLLMVPDGKDFVAENSGL

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1083)

HTSCNVYLNCKLLSTEEATRS
AVVWGTTQPTFNFSQ---VMPFSLTSKHLERLKNNVMVIEAWHKMGNPGNDRLLGLVKLP
LH

ENSGT00510000048072_0_Linker_1_2 (1083, 1399)

QFYISFKDPEISHLLLQAHYPVVAVDSYMPVIDVFTGSKSGSLRVILAMGSADQIVAL
QRLKNEEGME-PPITQRPAHFLDPP-PTKLTMQLEREGEELMEHVFEIHVESVKGLTPL-
--QSTVWGEADCYVQYYFPVQEAGSGALPGTELHTDGIELKPFRTATTLCVPDPVFNDEH
HHSLLVPADVPVQRLLVSAFMAPGA-VGGGIQFEVWCRYYYPNVRDQM------------
-VAKGTLPL-SRLCAMITMQ---HREEIGIQTFNLPLVPRTDSSEEFHL-RSSGLLDVSV
RYQRSVKMAARR-TAQTV

PF00168 // ENSGT00510000048072_0_Domain_2 (1399, 1547)

SLSVQIHRAAGLQAAARAVAEKNPSVQYYAGVGVNAYVSVHL
SFLPETERHSTRAVARSFCPEFEHHVE--IPCNLIVQKSSGEASCLGELLQSANITF-SV
YHQSIKSATDTMAARTSRDYLL-GTVTIPTRDLLRRR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1888)

ITLSEDVMPSHCTN
IMQTVVGGLELSVTFAHHNDRERILKAAQLLGWNGEESLEDSMD-----ESDEWEPSDSP
MVVTISTPRVWLPLHCVLLAGQMHLSKSTCCYLRYKLYDQEAMWTLLKRPKLCEDKKNVT
VNFKKGHKVTLRKSQGLIWFFREEKLEIQVWWAYGKENGMERPLDTDRLIGSAYVDLRAL
AERSRRTLSVGGVYPVFRCNAADLAGAAVRVHIALTST---SAAPT-L-T-PHCTEEHSN
SEDESTERAPDPSQQISESQ---SQNLDVRSSEITDGK--------RQE--DDVVFLEST
IAVSILVERAMHLSLKGSPLTEREVAA

PF00168 // ENSGT00510000048072_0_Domain_3 (1888, 1945)

PSSCVSFAVA-GADAPITTPVIENTESPVWDFQ
QQVRLSKELLLDPQQTLVFKVWHKA-GKVCRAALRRVVFCIHFLG---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGAGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-TSVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYGIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTKNVLLSER
ELRENTESSNTQSMIPSR---SCRGPAIKIDGKELAGHSS-RSTTP---RGKDHLYFAEN
SNAVKGSLWGLQQHLNQGTNVE-----TITLRGKAP-QKQLSLLNSSEFQPQISTVAKSH
SDSCILSSNTPPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSML-LDKVPPPMTEAIPR
SS-A------------L---N-SSENHFKGHSADHLLALAD-T-----------GAIQLL
LGSAELSQGHFWNGLGSPPDSPSPGSDEYCSSDLNDPQYDQSLLENLFYTV-PKSDVGTS
ELPSEDDGVEPSRTTNQSKASGRS-KVVESNEQKQ-KR--------AAVKKSRNP-----
VDQQELSRTPGHTPSMSLSVDRLALLGRVHSVRIIIETMGVPPDSPHM-TPSRKNFAGKP
PKPTAA--------KKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDG-VVKFQ
QRFVCPVEFGGPMIEHWWDSNLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQ
LPVQPENG---LSSLGPLKVTMELVLGHKDFTGISAKLS-SSTQPAPVSAATSSDTILPE
TGQDTAC---------TRNPQSSNKIHEETTKKTQNLVLPDQESANSVASNSS-IFMAMP
S-CNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNVYLNCKLFSTEEVSRS
VVSWGTAQPVFNFSQ---VIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSAQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPEKQGTRLMEHHFEFCVVMVKGLTPL-
--QATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEH
HHSLLLPTDVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNVRDQM------------
-VAKGTLPL-SRVCAMVTMQ---YREDVGMQSFNLPLTSGLEHSKELKN-QSSGFLDVGL
RYRRSPRTAEGILAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDITSIQSCKDYLL-GIVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDKGLPQDLD
LMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFE----SIPKDLVKKEEE---V---P
ATVTISTPRLWLPIHCVLLAGHTNIHKNTYCYLRYKLYNQEAFWTPLRKPKESTNKNQVL
ITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPHQTDSWIGSAYVDLSRL
GEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPL---SPHTEPARE-LDSMDCSSH
SESEQRPRKS-DALQLSPPH---VLQTSPTSTQVHGNSAAAQVCPV-Q--EGPPELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTDRKVSVPSCCVSFATA-TELSPVYTHVVENTDSPIWGFH
QQARLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPMESLMHLKEERQARRGIETPGA-LIPLFSA---LSFPASAGCDAFPRP
IARHVEGQLAHTSPKEDDFSSP-----A---RNGAIRSQATRHEEHVQNIRRFHESLQ-H
GEAVLTSDEKLTTAPSS-SHTSILTSLRKNLSELDEIQKYFSQKLSKPFLPFSSQSSPAV
SQSQESQRDPVAAGT--G-RQDP---ESQCILEKSNHLVSQVSSLISDLQTLT--RGS-Q
AALTSQQAR---SRSRAVTTIPDAQGTEAAGEGSTTLA--EPLAGAIEASTDSLPPPVEE
P--SKGGGMLHESLEQTVPITRVQS-------------------F---DDTEVGPDYSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDMS-EVLSPQPTEVQREGPSCP-PEPFPR-
EELKVKS----SPQKAV-----------SPQ-PAQGSPSQS-GVCEGGAYKMEVE-DLA-
SAKPQPVPSLTFSEAQEGIDSVGWR-AS--Q---VRKPVPEMLAESEA------FSS---
-------------EFSDS-------------SESF-EKF--PLHLPSQSKRED----YKD
------------------------SPAVRQKQVPTASEV-STRQTL---LLPEPVVVPNF
FLPPQQLEASLRMISHSPGLPPAATTDQDKSEATRGAL---------AQRPCRPRPYSI-
-------PPNLPEEETRR---IARI--FSSQYSKKTEET---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPVGARGRKK--
---RGLSDISPSTSLPPLVEGQLRCFLRLTVNKVIWKIAKPP-TCILVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQISG
LAQLSPTHHINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYSPLPTTDMTENVVLSEQ
EFRESTEPNNTQFLVPSR---PRRIPTTKMDGKELTANSS-RSTTP---RGKDHLYFAEN
SDAIKDSSFGLQHHLNSGQSLE-----CMTLKGRAP-RKQMSVLNSSEFQPQITTVAKSH
SDSCIVSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDEVHPPMKEDFLR
ASTHHPESTFPY---HR-IKA-LSKNQFKDHIEDHLLPPTK-STFWKHDTKADTRAIQLL
LGSAELSQGHYWNGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLESLFYTV-PKSDTSIS
DFFSED-DIVSSKKMSQSEALAISPKVLESND-KLKKR--------AAGKKNRNL-----
VEQQ-ISETPEDARVMTLSVDRLALLGRTHSVRIIIETMRVPPDSPQM-TSGKKSFSGRP
PNVTA--------TTKRTFFVKYHFPVGFSKGGLGKTALITEVVRLASSKITDG-MVKFQ
QRSVFPVQFDGPMIEHWWNSNLTFQIYTKKTPQKKPEVIGSASMPLRSVIQSELLSFSNQ
LPVRQENG---QTPLGPLKVTVELVIHNKDFTCVNTKLR-NSTQHGPLCTLTSPDKTLSE
PGQHVTC---------TKNPENLNQIHEEVAKKVQNLILSNPKSPSPVVPNPS-TFMAVP
ASHNLANQTDGSTKESALLLHVLLMVADGKDFITGESDKPPPCNVYLNCKLFSTEEVTRS
IIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVQSPGQDKLLGLVKLP
LHQFYVSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPS-IASVTMAEDQRNGLMEHHFELHVESIKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEFLENGISLKPFRSATTLCVPDPIFNSEH
HHSLLLPAEVPLQRLLLSVFSAQGPMPGGGVQFEIWCRYYYPNVRDQM------------
-VARGTLPL-SRICAMVTMQ---HHEDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
KYRRTPRTAEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVEIIRACGLQAAAKALAELEPALQFSATVGVNAFVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHVE--FSCNLVTQHCSGEACFLAELLEFAEVTF-AI
YHEDTKSATDITSIQSIRDYLL-GVVKVPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

IILPEDGALPHCLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NNLKNLVTMDEE---E---P
ATVTISTPRLWLPIHCVLLAGQKHIHKNIHCYLRYKFYDHEAFWTPLKKPKESPNKKQVM
VTFKASKRAEVNRGPSLLWYFREERLEVQVWRAYGNDS-VERPHQTDSWIGSAYVDLVRL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSP---SPHPGPAHE-LDSVDCSSH
SESEQFPRRH-DEIQRSPSP---DHQKSPASTQVPCNTTTGEVCPA-Q--EGPDELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGIPLTERKVSIPSCCVSFATA-DEPSPVFTHVVENTDSPIWNFQ
QQSRLSKEFLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQSRRGMETPGS-RIPIHSP---FSFPASGMYAAFPGW
VARWTPEQPAHTSSRGLDFSSP-----T---RSSTARSQASRHEEHVQNIRRFHESLQ-Q
GEAVLPHDDKLTTLPLSSSRTSILTSLRRNLSELDQIQRYFSQKLTKPLLPLSPQPP-AV
MQSQETHRDHPGPG--AS-SLDP---DSQCLLEKSNNLVLQVSSLITDLQTIT--RNS-Q
ASLSSHQAR---SRSGEVPTLPDAQDTGAMQERRTAPS--MSVAQVMDEGRNCLTPPTLE
ETSSR-RGLLHESLGHTVPNTRMQS-------------------SEET---EADPVYSDE
DYEEDIIEPRTLNDITTVTDKTSPWSSFMSDTS-EIISLQPDEVHREGPSCPS-KPFPR-
EELKGKSSPLSSPGRAV-----------NPHLLRQGSPRQSLVACEGEASQARDG-EPA-
LTDPQLISQVILSGAQQSKTSMGLS-SP--RADQDQEPKPEAQTENEA------AST---
-------------ELSDS-------------ADSF-EKF--PLSLASQSRKESHQGLPIN
------------------------CPDIHQKQATSGSEV-STRQSL----LPEPIVVPNF
FLPSQQLEASLRILSLSTALPPPATTDQDKSEASSRPL---------SGRPARPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-TSVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATDVTKNVLLSER
ELRENTESSNNQSMIPSR---SCRVPAIKIDGKELAGNSS-RSTTP---RGKDHLYFAEN
SDAVNGSLCGLQQHLSHGTNVE-----TITLRGKAP-QKQLSLLNSSEFQPQMSTVAKSH
SDSCILSSNTRPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSML-LDKVPPPMTEDIPR
SS-A------------L---N-SSENQSKGHSADHLLPSAD-T-----------RAIQLL
LGSAELSQGHFWNGLGSPPDSPSPGSDEYCSSDLNDPQYDQSLLENLFYTL-PKSDVCTS
ELLSEDDGVEPSRTMNQSKASGRS-KVVESNEHKQKKR--------AAVKKSRNP-----
VDQQELSRTPEHTPAMSLSVDRLALLGRVHSVRIIIETMGVPPDSPHM-TPSRKNFAGKP
PKPTAA--------KKRTFFVEYHFPVGFSKSGLGKTTLITEVVRLASSKITGG-VVKFQ
QRFVCPVEFDGLMIEHWWDSNLTFQIYAKKTPQKKPEVIGSASLPLQAVIQSELLSFSSQ
LPVQQENG---LSSLGPLKVTMELVLGSKDFTGISAKLS-SSTRLAPVSAATSSDTILPE
AGQDTAY---------TKNPQSSNKIHEETTKKTQDLVLTDPESANSVASNS----MAVP
S-RNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNVYLNCKLFSTEEVTRS
VVSWGTAQPVFNFSQ---VIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGQQNGSLRVFLAMGSSAQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPEEQGTGLMEHHFEFCVVMVKGLTPL-
--QATVWGEADCYVQYCFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEQ
HHSLLLPTDVPVQRLLLSAFSAQGLGPGGGVQFEVWCRYYYPNVRDQM------------
-VAKGNLPL-SRICAMVTMQ---YREDVGMQSFNLPLTSRLEHSKESKS-QSSGFLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIFRACGLQAAAKALAEQEPALQFSAIVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDITSIQSCKDYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDKGLPQDVD
LIQKIVGGLELSVSFAHPGDRERVLEAAELLGWNFE----NIPKDLAKT-EE---V---P
VTVTISTPRLWLPIHCVLLAGHTNIHKNTYCYLRYKLYNQDAFWTPLRKPKESTNKNQVL
ITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPQQTDSWIGSAYVDLSRL
GEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPL---SPHTEPARE-LDSMDCSSH
SESEQHPRKS-DELQLSPPR---VLQTSPTSTQVHGSSAAAEVRPT-Q--EGPPELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTDRKVSVPSCCVSFATA-TEPSPVYTHVVENSDSPIWSFH
QQARLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPMESLMHLKEERQGRRGREPPRS-MIPLFSP---LSFPASAICDAFPGP
VARHIQGQLVHTSPKEDDFSSP-----A---RNGAIKSQAARHEEHVQNIRRFHESLQ-Y
GEAILTNEEKPTTAPSS-SHTSILTSLRKNLSELDEIQKYFNQKLSKPFLPFSSQSSTAV
SQSQESHRDPVGTGT-LE-HQDP---ESQCILEKSSNLVLQVSSLISDLQTIA--RAS-Q
AALTSQQAR---SRSRAVATLPDVQDNEAAGEGSSTLE--EPLAGAIEASTHFLPPPVEE
P--SKGGGMLRESLEQTVPIPRVQS-------------------S---DDTEVGPDYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDMS-EVLSPQPSEVQREGPSCP-PEPFPR-
EELKVKS----SPQKTV-----------SPQ-SAQGSPSQS-VVCEGGAYKIEVE-DLA-
STKPQPVPNLTFSEAQESSDSVGWR-SS--QINQDRKPRPEILAESEA------FSS---
-------------EYSDS-------------SESF-EKF--PLHLPSQSKRKD----YVD
------------------------SPAVRQKQVPTGSEV-STRQKL---LLPEPVVVPNF
FLPPQQLEASLRMISHSPGLPPAATADQDKSEATRGAL---------AQRPCRPRPSSL-
-------PPNLPEEETRR---IARI--FSSQYSKKTEEA---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPVGKVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPTTDVTENALLSER
GPRENTESSNTQSMILSKS-Y--GAPTIRSDGKELAGNSS-RSTTP---RGKDHLYFAEN
PDAVKSSLCGLQQHLNSGPSLE-----TVSPRDKSP-QKQMSLLNSSKFQTKISTVSKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMLISAMNSSPDTSML-LDKVPPPVIEDPFT
SS-V------------P---N-SSKDQFKDHSDNHLLPWTE-PMFCKDDTKADTRAIQLL
LGSAELSHGQFWNGLGSPPDSPSPGSDVYCSSDLNDPQYDQSLLETLFYTV-PKSEVSTG
DFLSEDDSMEPSKTMNQSKASGRSSKVVGSSEHQLKKR--------ASVKKSRNV-----
ADKEVLSRTPGHTTATSLSVDRLALLGRIHSVRIIIETMGVPPDSPRM-TPSRKSFAGKP
PKPAAAT----SAAKKCTFFVEYHFPVGFSKSGLGKTALITEVIRLASSKVADG-VVKFQ
QRFVCPIEFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLPLRAVIQSEQLSFSNQ
LPVQQENG---SSSLGPLKVTLELVLGNKDFTVVSAKLS-SPSKHTSLSAATSPDTILPE
TLQDTTC---------TKNPQNSNQIHEETAEKTQNLVLSNPKSANPIDS-NS-GFMTIP
H-HHLVHQTNGSSRENSLLLHVLLMVPDGKDFVSGELEKPPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNVYLKCKLFSTEEVTTS
AISWGTPQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPENQGNRLMEHHFEFHVVMVKGLMPL-
--QATVWGEADCYIQYYFPFQDSQPRVLQGPDFLENGITLKSFRTPTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSIFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGMQNFNLPLTPRLENSKELKN-QSSGLLDVGL
RYRRSPRTTEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTRHVACSFCPEFSHHIE--FPCNLVIQHSSGEACFLAELLEFAEIIF-AI
YHENTKSVSDIASIQSCKEYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDEGLPQSLE
FMQKIVGGLELSVSFTHPGDRERVLEAAELLGWTFD----SSLKDLVKVEEE---V---P
ATVTISTPRLWLPIHCVLLAGHKNIHKNTYCYLRYKLYSQEAFWTPLRKPKEATNKNQVV
ITFKASKRAEVTRSPSLLWYFREEKLEIQVWRAYGNDS-LERPHQTDSWIGSAYVDLSRL
GEKSARTLTVSGVYPLFGRNASDLSGAALRIHVVLSPL---SLHTEPTRE-LDSMDCSSH
SESEQLPRTN-DGLQLSPPC---VLQKSLASTQVDCNSTAAEVCPA-Q--EGSPEQDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVSIPSCCVSFATA-TEPSPIYTHVIENTDSPIWNFQ
QQSRLSKELLLDPHQALVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLLHLKEERQARRGTAAPDS-LIPLFSH---FSIPASSMCDTFPGP
IERHIQGQLAHTSPEEVDFSSL-----A---RNGTIRSQAARHEEHVQNIRRFHESLQ-H
GEAVLASDEKLATVPLS-SQTSILTSLRKNLSELDEIQKYFTQKLSKPFLPFSSHSSPAI
SKSLESQRDYVGPET--S-SRDP---ENQCILEKSSNLVMQVSSLISDLQTIT--RDS-Q
AALASHQAR---SRSRTVTTLPDAQDTEALQGRSTTPE--EPLARAGEASTNSLPAPVLE
EISEG-GGLLHELVEHAVPITRVQR-------------------S---DDTEVDPELSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFTSDMSGEVISPQPNEVQREGSSCP-PGPFPR-
EELKVRSSLMSSPQKAV-----------NPQ-AGRGSPSHS-IACEGGAYKTKVE-ESA-
SAQPLLVPGLTVSGAKESNDSVGWG-SP--QKKQDKRPMPEILAERET------FSS---
-------------EFSDS-------------SESF-EKF--PLYLPSQSKRENLKEPPMD
------------------------SPSVRQEQVTTGPGM-STRQSL---LLPEPIVVPNF
FLPPQQLEASLRMISHSPALPPPATTDQDKSETTRGAL---------AQRPCRPRPNSL-
-------PSNFPEEETRR---IARI--FSSHYSQKPGEA---------------------
-------------------------------------------------------

MQSSTGLSLCACADGGAPVRSRRGSVAKHPGYCSLLAGRRPGAFPSPGFREAVRGRAASS
CLPGCPALPVAGERRRRGRDGGRTRLGRWDRSWIGEELGLVMKQRKGLGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-TCVLVRVRWWGETSDGT
LFCPKDALQTEPSTVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITRLDHLPVGRVEISG
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYNSYNPFPTTDKTENVLFSER
GFREDAEPCNTQFLVPSRP---QRIPTIKADGKELAASSS-RSTTL---RGKDHLYFTEN
SDTMKDSFFGLQHHLNSGQSLE-----SVTLKGRAA-QKQMSLLSSSEIQPQITTVAKSR
SDSCILSSNHPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDKVPPPMMEESLR
AS-T------------Q-MRA-FPQNRLKDHKEDHLPSPTE-NTFWKHDTKADTSAIQLL
LGSAKLSQGHLWDGLGSPPDSPAPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDSSIS
DFLSEDDDSVPSKKMNQSKAVARSPKILESRDQKLKK---------AAGKKNRNL-----
VEQQMLSGAPEDAQAMTLSVDRLALLGRTHSVRMIIEAMRVPPDSPQV-TPGRKNDAGRP
LKLTT--------ARKRTFFVEYHFPVGFSKSGSGKTALITEVVRFASSKIADG-MVKFQ
QRFVFPVRFGGPMIQHWWNSNLTFQIYTKKTPQKKPEVIGSASLPLRAVIQSELLSFSDQ
LPVQHENDQIDQIPLGPLKVTVELVTDNKDFTGVNTKLS-SNIQHTPHCEPTSPDKILPE
ANQDITS---------TKNLKNLNQIYEETTKKAQNLVLPNPKSLSPVAPHPS-NLMTPP
ASHNLVSRTNGSTQEDALLLHVLLMVPEGKDFTPG

PF00168 // ENSGT00510000048072_0_Domain_1 (996, 1044)

ESEKQASCNVYLNCKLFT-EEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLDRLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISHLLLEAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQQP-VASVAMAEDQRDGLMEHHFEFHVEMLKGLVPL-
--QATVWGEADCYVQYYFPVQDSQASALKGPEFLENGIALKPFRTATTLCVPDPIFHSEH
HHSLLLPPEVPVQRLLLGAFSAKGVVPGGGVQFEIWCRYYYPNVRDQM------------
-VATGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRSLRTAEGVLAARTVSISVQIIRACGLQAAAKALAEQEPALQFSASVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSYHLE--FPCNLVTQHSSGEACFLAELLEFAEITF-AI
YHENTKSVSDITSIQSCKEYLL-GVVKIPTKELLIKR-SGITGWYPVILPEVGGLPHGLE
LMHTIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----DSLKDLVKMDEE---E---P
ATVTISTPRLWLPLQCVLLPGHRHIHKSTHCYLRYKLYDLEAFWTPLKKPKESANKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPNPEPPRE-LDSMDCSSH
SESEQLPRRN-EEIQLTPPY---GHPKLPVPTQIPCSSTTAEVCLA-Q--EGSSELDG-T
FAVSILVERAMHLSLKGSPLTERK

PF00168 // ENSGT00510000048072_0_Domain_3 (1885, 1952)

VPVPSCCVSFATA-DEPSPIYTPVVGNTDSPVWNFQ
QQSRLSKELLLDPKQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLENLMRFKEERQARRGVETTGS-LIPVYSP---FSFPASDMYAPLPSC
IARSTPDQPAHISSKELDFSSP-----R---KSGTTRSQASRHEEHVQNIRRFHEFLQ-Q
GEAALPNDDKSTTSPLS-SNTSILTSLRKNMSELDQIQRYFSQKLTKPFLPLSPQTPTTI
LECQESPRDNVGPGA--S-RLDP---ESKCILEKSNNLVLQVSSLITDLQTIT--RNS-Q
AVLSSHRAR---NRSKEVTTLPDLQDAEALQEQSPTPD--EPLARAPDEGTNSPPAPVPE
ETSNG-RGLLSESLGRMVPITRMQS-------------------S---EDTETGPADSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDIS-EIISPPPDEVPRRGPSCPSSEPFPR-
EELKGRSGFLSGPDRAA-----------NL-------PREDPAACENETSTGEVR-EPA-
SANPRLLPFLKLSGAKQSSTFVGQR-PP--RADQNKEPKREAQAEDKA------ASS---
-------------ELSDS-------------ADSF-ENF--PLHLVSQNKRETPKGPPVH
------------------------SPDTRQKQEATGPEV-SARQSH---LLPEPIVVPNF
FLPPQQLEASLRMLTLSTALPPAATTAQVSWPIKPGAKLEAAEATVHGKEGCPPAPRCPL
RGWSPRQPPCCPCPGEAHSLSLHRSPGLPSSLSPHTPPGPGGTGRLKTWDHGGTEALRRA
PHNNREVPGAGTAACLLHSSPFRWTPPRSACISRERTQRPWRLRACGTAACWAPS

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDVSPSTSLPPLVEGQLRCFLKLTISKVVWKIAKPP-VCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKLDHLPVGRVQING
LAQLSPTHQINGFFTIVSPASKKLGDLQVSLALEPLSETYDSYKPLPTTDMTENVLLSER
GLRENTESSNTQAMIPSR---PCGAPAIKTDGKELPGNSS-RSTTP---RGKDHLYFAEN
PDAVKSSLCGLQHHVNSGPSLE-----TVLQSGNAP-QKQMSLLNSSMFQPHISTVAKSH
SDSCILSSNNPPAKDLLSALLEQGNKLRNAMLISAMNSSPDTSML-LDKVPPPLMEDAFR
SS-V------------P---Y-SSKNQFKDHSDDHLLPLTE-N-----------LAIQLL
LGSAELSQGHFWNGLGSPPDSPSPGSDVYCSSDLNDPQYDQSLLENLFYTV-PKSEVSAS
DFLSGDDSMEPSKTVTQSKASGRS-KVVGSGEHKLRKR--------AADKKSRSV-----
VDEQELSRIPVHAPATSLSVDRLALLGRVHSVRIIVETMGVPPESPHM-TPSRKSFAGKP
PKPAAAAAAAAAAAKKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDG-VVKFQ
QRFVCPIEFGGPMIEHWWNSNLNFQIYAKKPPQKKPEVIGSASLPLRAVIQSELLSFSNQ
LPVQQEDG---SSSLGPLKVTMELVLGNKDFTGVSAKLS-SSTQHIPLSAAPGLDMILPE
TLQDTTC---------TKNPQNSNQIHEETAKKTQNLVLPNPKSANPIASDSS-GFMTMP
N-HSLVHQTNGSSKDNALLLHVLLMVPDGKGFVSGESEKPPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNVYIKCKLFSTEEVTTS
AISWGTAQPVFNFSQ---VIPVSLSSKHLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGIL-PPFSPRPAHFLDQPP-VASAALPESQGNRLMEHHFEFHVVMVKGLVPL-
--QATVWGEADCYVQYCFPSQDSQPSVLQGPDFLENGVTLKPFRTSTTLCVPDPIFSSEH
HHSLLLPADVPVQRLLLSAFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDTGMQNFNLPLTPRLENSRELKN-QSSGFLDVGL
RYRRSPRTAEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGLNTSVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDIASIHSCKDYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1892)

VILPEDEGLSRDLE
FMQKIVGGLELSISFTHPGDRERVLEAAELLGWTFD----GSLKDLVKMEEE---V---P
ATVTISTPRLWLPLHCVLLAGHRNIHKNTYCYLRYKLYSQEAFWTPLRKPKESTNKNQVL
VTFKASKRTEVTRSQSLLWYFREEKLEIQVWRAYGNDS-LERPHQTDSWIGSAYVDLSRL
GEKSQRTLTVSGVYPLFGRNAPDLSGAALRVHVVLSP------HTEPTRE-LDSMDCSSH
SESEQLPSKK-DELQLSPPC---VLQKSPASALVCCTSTAAEVGPP-D--EGPPELDG-T
FAVSILVERAMHLSLKGSPLTERKVSIPSSC

PF00168 // ENSGT00510000048072_0_Domain_3 (1892, 1974)

VSFATA-AEPSPVYTHVVENTDSPIWNFQ
QQSRLSKELLLDPHQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLMHLKEERQARRGTAAPGS-LVPVFSP---FSFLASSVCDAFPGP
VARHMQGQLAHTSPKEVDVSSP-----A---RNGALRSQAARHEEHVQNIRRFHESLQ-H
GEAALASDERVATAPLS-SHPSILTSLRKNLSELDEIQKYFTQKLSRPFLPFSSHSSPAI
SKSQESQRDSVGLGT--S-SRDP---ENQCILEKSSNLVLQVSSLISDLQTIT--RDS-Q
AAWTSRQAR---SRSRAVTTLPDAQDTEAMGGRSTTPE--EPLAGAGEASTNPLPAPVLE
ETSE--RGALHASVEHIEPITRVQS-------------------G---EDTEVDPDLSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDMS-EVFSPQPNEGQREGPSCP-PGPFSR-
EELKVRSSLLSSPQKAV-----------KPP-SVEGSPNQR-VACEGGAHKTKVE-ESA-
STKPRLVPG-----AQENKDSVGWS-SP--QISQDKRPMPEALAESDA------FSS---
-------------EFSDS-------------SESF-EKF--PPHLPSQSKRENHKEPPLD
------------------------SPASRQKQVTAGPEV-STRQN----LLPEPIVVPNF
FLPPQQLEASLRLISYSPALPPPATADQDKSETTRGAL---------AQRPCRPRPDSL-
-------PPSFPEEETRR---IAQI--FSSRCSQKPDDS---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQRPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-ASVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYGIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTKKVLLSER
ELRENTESSNTQSMIPSR---SCRGPAIKIDGKELAGHSS-RSTTP---RGKDHLYFAEN
SDAVQGSLCGLEQHLNQGADVE-----TMTLRGKAP-QKQLSLLSSSEFQPQISTVAKSH
SDSCILSSNTPPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSML-LDKVPPPMTEAVPR
SS-A------------L---N-SSENHLKGHSADHLLPLAD-A-----------GAIQLL
LGSAELSQGHFWNGLGSPPDSPSPGSDEYCSSDLNDPQYDQSLLENLFYTV-PKSDVGTS
ELPSEDDGVEPSRTMNQSKASGRS-KVVESNEQKQ-KR--------AAVKKSRNP-----
VDQQELSRTPGHTPAMSLSVDRLALLGRVHSVRIIIETMGVPPDSPHM-TPSRKNFAGKP
PKPTAA--------KKRTFFVEYHFPVGFSKSGLGKTTLVTEVVRLASSKITDG-VVKFQ
QRFVCPVEFGGPMIEHWWDSNLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQ
LPVQQENG---LCSLGPLKVTMELVLGNKDFTGISAKLS-SSTQPAPVSAGTSSDTMLPE
TGQETDC---------TRNPQSSNKIHEETTKKTQNLVLPDQESANSVASNSS-VFVAMP
S-CNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNVYLNCKLFSTEEVTRS
VVSWGTAQPVFNFSQ---VIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSAQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPEKQGTRLMEHHFEFCVVMVKGLTPL-
--QATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEH
HHSLLLPTDVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNIRDQM------------
-VAKGTLPL-SRICAMVTMQ---YREDVGMQSFNLPLTSRLEHSRELKN-QSSGFLDVGL
RYRRSPRTAEGILAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQDPALQFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FTCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDITSIQSCKDYLL-GIVKVPTKDLLVKR-SGIKGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

VILPEDKGLPQDLD
LMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFE----SIPKDLVKTEEE---V---P
ATVTISTPRLWLPIHCVLLAGHTNIHKNTYCYLRYKLYNQEAFWTPLRKPKESTNKNQVL
ITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPHQTDSWIGSAYVDLSRL
GEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPL---SPHTEPVRE-LDSMDCSSH
SESEQHPRKS-EALQLSPPH---VLQTSPTSTQVHGNSAAAQVCPA-Q--EGPPELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTDRKVSVPSCCVSFATA-TEPSPVYTHVVENTDSPIWGFH
QQARLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPMESLMHLKEERQARRGIETPGS-LIPLFSA---LSLPASAGCDAFPRP
IARHVEGQLAHTSPKEDDFSSP-----A---RNGAIRSQAARHEEHVQNIRRFHESLQ-H
GEAVLTSDEKLTIAPSS-SHTSILTSLRKNLSELDEIQKYFRQKLSKPFLPFSSQSSPAV
SQSQESQRDPVGAGT--G-RQDP---ESQCILEKSNNLVLQVSSLISDLQTLT--RGS-Q
AALTSQQAR---SRSRAVATIPDAQDTEAAGEGSTTPE--EPLAGAIEASTDSLPPPVEE
P--SKGGGMLHESLEQTVPITRVQS-------------------I---DDTEVGPDYSDE
DYEEDIIEPRTLNEVTTVTDKTSPWSSFMSDLS-EVLSPQPTEVQREGPSCP-PEPFPR-
EELKVKS----SPQKAV-----------SPQ-PAQGSPSQS-GVCEGGAYKIEVE-DLA-
STKPQPVPSLTISEAQESSDSVGWR-AS--QVNQVRKPMPEMLAESEA------FSS---
-------------EFSDS-------------SESL-EKF--PLHLPSQSKRED----YKD
------------------------SPAVR--QVPTGSEV-STRQTL---LLPEPVVVPNF
FLPPQQLEASLRMISHSPGLPPAATTDQDESEATRGAL---------AQRPCRPRPYSI-
-------PPNLPEEETRR---IARI--FSSQYSKKTKET---------------------
-------------------------------------------------------

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--------RQTHPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEITF-AI
YHENTKSVSDIASIQSCREYLL-GVVKIPTKELLIKR-SGITGWYPVFLPENTGLPHGLE
LMQKVVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLKDLVKTDEK---E---L
ATVTISTPRLWLPVHCVLLAGHKHIHKNTYCYLRYKLYDHEAFWTPLKKPKESTDKNQVM
VTFKASRRAEVTRGPSLLWYFREERLEIQVWRAYGSDS-VERPHQTDSWIGSAYVDLARL
GEKSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSH---SPHAEPTQE-LDSVDCSSH
SESEQLPRGRPEEMQPFPPR---DHEKSSASAQVPGGSGPAEVCLA-Q--EDPAELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTKQKVPVPSCCVSFATA-VESSPVYTHVVENTDCPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVNLSPLLSGFQFICGWYNITDLSG
ECQGQIKVAISPLESLMHIKEERHARRGMKTQAP-LISMYSP---FSFPASDICAAFPSG
SARHTQDQLTQTSLKDLDFSSP-----G---RSNTTRSPESRHEEHVQNIRQFHESLQ-Q
GEPVSTSDSRFGTSPLS-SNTSILTSLRKNLSELEEIQQYFSQKLTKPFPPFSPHTNPAI
SQCQENRRDCLGAGV--R-RHDL---QSQCILEKSSDLVLQINSLISDLQTIT--KNS-Q
AALTSHQSR---NKRQEVATLPDAQDTEAVQDRSTTPD--EPVASAAEAGTNSPAPPALE
GTSNG-GRLPQESLGHTVPVSRMQS-------------------S---EEAEAGPVYSDE
DYEEDIIEPRTLNEVTTVTDRTSPWSSFMSDTS-EGISPQPDKVPKEGSSSPSPGPSPR-
ELLRARSNFLSSPKVA--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------SLPPLVQGPARCFLRCSVPRVLWAAPQPPA---VVRLRWWGETSGGT
VLQPACR--AGQPAGRTSARFAVRCGPRQLAAYLADMGVLVLEVLTKLDHLLLGRAQITK
LSQLSPSHPIKGSFPVVSPTSGKLGELQVSLVLEPLPELYDTSSCVLTTQGGSVAAAAQG
SSKSQ-------LPAPSQQ----PRHTQVTVEQDCV--DNSKATS---PRYPSHRIFNQM
SGTLDNKGHPLWRPLARGVTHEGVVLKGVPKLQVYW-RQPLSFPSSADPEALP------R
RSTWVLSMHNAATKDLLSALLDQGSKLRDAMVVSAMKSSPDMEIE-LNKISDFIERDAFK
A-------------PTKSPKG--LKSSFVHTPEDSHHFGSE-VSGQQLDLNSEQRAIQLL
LGSADFSPGCFWDQAGSVWDSLSLGSEVY-DSEVGDPHYDQSLLEKLFYTT-AKSDSSLS
DFLSEDD-VKSSKKASKTETLKKAGPVNPQKD-----FHAF--DQNVTETKPRYLPKDPV
IK--LNLE---MALLTSLGTDRLALLQQIHLARVTIESLKIPPES-IEISSRRKGLLGKP
PWPLS--------VHKCTFFVEYHFPVRVSKDGKGQVSIATEAIRVASSKITDD-VVKFQ
QQSVFPVCFTGTMIEHWWSSDLAFKIYMRKSTQKKAVAIGSAALQLRRVIEAELFSVSQD
IPVEKEGD---HTQVGPLKVSLQLAASSRDLAHVAAR---------PAHTLRGAQLALQE
PSRTSVN---------AASPLCSTRSPQDCQEPGA-------SSRDMVQ--PL-RPEPAA
AAWDVLARRAP-AEEDGLLLHVLLMVPDGKDFFAEGCGRPTSCNVYLNCKLLSTEEATRS
TVIWGTTQPAFNFSQASHVMPFSLTSKHLERLKNNVMIIEAWSKLGGPGCDKLLGLVKLP
LHQFYISFKDPKISHLLLQAQYPVVAVDGHVPVMDVFSGSKSGSLRVTLAMGSADQIVAL
QRLKTGEGMA-PPVTPRPPHSLDHP-ATKPTVQLEPEGEDLVEHVFEIHVESVKGLTPL-
--QSTLWGEADCYIQYYFPVQEAACGALQGPGLHEDGITLKPFRTATTLCVPDPIFNDEH
HHSLLVPADVPVQRLLVSAFMAPGA-AGGGIQFEVWCRYYYPNVRDHL------------
-VARGALPL-SRLCAMVTLQ---HRKEIGIQTFNLPLVPRADSSEEFHL-RSSGLLDVSV
RYQRSMKIAAGI-TAQAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1473)

LSVRIHRAAGLQAAARAVAQKNPSVQYYAGVGVNAYVCVLL
SFLPQAQTRSTPAVPCSFCPEFEQHLE--FPC

ENSGT00510000048072_0_Linker_2_3 (1473, 1887)

HLITQKSSGETSSLGEFLQSASIFF-SI
YHQSTKSDTDKLADRTSRDYLL-GTVTIPTRDLLTRR-SGISGWYPVTLSDEPMPPRRID
AVQAVVGGLEVSVAFAHQGDRERVLEAARLLGWSDKEL-HEDSR-----ERAG------R
VAVTISTPRVWLPLHCVLLAGQTHLHRSTHCYLRYKLYNQEATWTWLKRPKVSEDAENVT
VSFRKPSKVTLRRSQGLLWFFREEKLEIQVWWAYGKENEVERPLDTDRLIGSAYVDLATL
AERSRRTLSVSGVYPLFRCNAADLAGAAMRVHISLAPT---PAPTA-LPR-LPCAEECSN
SEDEGTGESPALSQQLSDK-----QQVDNASSGITNGE--------PQK--EDMMFLENT
VAVNILVERAMHLSLKGSPLTEREVA

PF00168 // ENSGT00510000048072_0_Domain_3 (1887, 1950)

APSSCVSFAVA-GADAPVTTPVIGNTDSPVWDFR
QQARLFKELLLDPQQTLVFKVWHKA-ESERVIGFASVDLSPLLSGFQLVCGWYNITDFSG
QCRGQIKVAVSPLQNINHLKEERQAR----------------------------------
------------------------------------------------------------
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-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-TSVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYGIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTKNVLLSER
ELRENTESSNTQSMIPSR---SCRGPAIKIDGKELAGHSS-RSTTP---RGKDHLYFAEN
SDAVKGSLCGLQQHLNQGTNVE-----TITLRGKAP-QKQLSLLNSSEFQPQISTVAKSH
SDSCILSSNTPPAKDLLSALLEQGNKLRNAMLISAMNSNPDTSML-LDKVPPPMTEAIPR
SS-A------------L---N-SSENHFKGHSADHLLPLAD-T-----------GAIQLL
LGSAELSQGHFWNGLGSPPDSPTPGSDEYCSSDLNDPQYDQSLLENLFYTV-PKSDVGTS
ELPSEDDGVEPSRTMNQSKASGRS-KVVESKEQKQ-KR--------AAVKKSRNP-----
IDQQELSRTPGHTPAMSLSVDRLALLGRVHSVRIIVETMGVPPDSPHM-TPSRKNFAGKP
PKPTAA--------KKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDG-VVKFQ
QRFVCPVEFGGPMIEHWWDSNLIFQIYAKKTPQKKPEVIGSASLPLRAVIQSELLSFSSQ
LPVQQENG---LSSLGPLKVTMELVLGHKDFTGISAKLS-SSTQPAPVSAATSSDTILPE
TGQDTAC---------TRNPQSSNKIHEETTKKTQNLVLPDQESANSVASNSS-IFMAVP
S-CNLVHQINGSNKESGLLLHVLLMVPDGKDFVFGEREK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNVYLNCKLFSTEEVTRS
VVSWGTAQPVFNFSQ---VIPVSLTSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSAQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPEKQGTRLMEHHFEFCVAMVKGLMPL-
--QATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPVFNSEH
HHSLLLPTDVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNVRDQM------------
-VAKGTLPL-SRVCAMVTMQ---YREDVGMQSFNLPLTSRLEHSKELKN-QSSGFLDVGL
RYRRSPRTAEGILAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDITSIQSCKDYLL-GIVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDKGLPQDLD
LMQKIVGGLELSVSFAHPGDRERVLEAAELLGWSFE----SIPKDLVKKEEE---V---P
ATVTISTPRLWLPIHCVLLAGHMNIHKNTYCYLRYKLYNQEAFWTPLRKPKESTNKNQVL
ITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPHQTDSWIGSAYVDLSRL
GEKSPRTLTISGVYPLFGRNASDLSGAALRIHVLLSPL---SPHTEPARE-LDSMDCSSH
SESEQHPRKS-DALQLSPPH---VLQTSPTSTQVHGNSAAAQVCPA-Q--EGPPELAG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTDRKVSVPSCCVSFATA-TELSPVYTHVVENTDSPIWGFH
QQARLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPMESLMHLKEERQARRGIDTPGA-LIPLFSA---LSFPASAGCDAFPRP
IARHVEGQLAHTSPKEDGLSSP-----A---RNGAIRSQAARHEEHVQNIRRFHESLQ-H
GEAVLTSDEKLTTAPSS-SHTSILTSLRKNLSELDEIQKYFSQKLSKPFLPFSSQSSPAV
SQSQESQRDPVAAGT--G-RQDP---ENQCILEKSNHLVSQVSSLISDLQTLT--RGS-Q
AALTSQQAR---SRSRAVTTIPDAQGTEAAGEGSTTLE--EPLAGAIEASTDSLPPPVEE
P--SKGGGMLHESLEQTMPITRVQS-------------------I---DDTEVGPDYSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDMS-EVLSPQPTEVQREGPSCP-PEPFPR-
EELKVKS----SPQKAV-----------SPQ-PAQGSPSQS-GVCEGGAYKIEVE-DLA-
SAKPQPVPSLTFSEAQEGSDSVGWR-AS--QINQVRKPMPEMLAESEA------FSS---
-------------EFSDS-------------SESF-ETF--PLHLPSQSKRED----YKD
------------------------SPAVRQKQVPTGSEV-STRQTL---LLPEPVVVPNF
FLPPQQLEASLRMISHSPGLPPAATTDQDKSEATRGAL---------AQRPCRPRPYSI-
-------PPNLPEEETRR---IARI--FSSQYSKKTEET---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPVGKVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPTTDVTENALLSER
GPRENTESSNTQSMILSKS-Y--GAPTIRSDGKELAGNSS-RSTTP---RGKDHLYFAEN
PDAVKSSLCGLQQHLNSGPSLE-----TVSPRDKSP-QKQMSLLNSSKFQTKISTVSKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMLISAMNSSPDTSML-LDKVPPPVIEDPFT
SS-V------------P---N-SSKDQFKDHSDNHLLPWTE--------------AIQLL
LGSAELSHGQFWNGLGSPPDSPSPGSDVYCSSDLNDPQYDQSLLETLFYTV-PKSEVSTG
DFLSEDDSMEPSKTMNQSKASGRSSKVVGSSEHQLKKR--------ASVKKSRNV-----
ADKEVLSRTPGHTTATSLSVDRLALLGRIHSVRIIIETMGVPPDSPRM-TPSRKSFAGKP
PKPAAAT----SAAKKCTFFVEYHFPVGFSKSGLGKTALITEVIRLASSKVADG-VVKFQ
QRFVCPIEFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLPLRAVIQSEQLSFSNQ
LPVQQENG---SSSLGPLKVTLELVLGNKDFTVVSAKLS-SPSKHTSLSAATSPDTILPE
TLQDTTC---------TKNPQNSNQIHEETAEKTQNLVLSNPKSANPIDS-NS-GFMTIP
H-HHLVHQTNGSSRENSLLLHVLLMVPDGKDFVSGELEKPPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNVYLKCKLFSTEEVTTS
AISWGTPQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPENQGNRLMEHHFEFHVVMVKGLMPL-
--QATVWGEADCYIQYYFPFQDSQPRVLQGPDFLENGITLKSFRTPTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSIFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGMQNFNLPLTPRLENSKELKN-QSSGLLDVGL
RYRRSPRTTEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTRHVACSFCPEFSHHIE--FPCNLVIQHSSGEACFLAELLEFAEIIF-AI
YHENTKSVSDIASIQSCKEYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDEGLPQSLE
FMQKIVGGLELSVSFTHPGDRERVLEAAELLGWTFD----SSLKDLVKVEEE---V---P
ATVTISTPRLWLPIHCVLLAGHKNIHKNTYCYLRYKLYSQEAFWTPLRKPKEATNKNQVV
ITFKASKRAEVTRSPSLLWYFREEKLEIQVWRAYGNDS-LERPHQTDSWIGSAYVDLSRL
GEKSARTLTVSGVYPLFGRNASDLSGAALRIHVVLSPL---SLHTEPTRE-LDSMDCSSH
SESEQLPRTN-DGLQLSPPC---VLQKSLASTQVDCNSTAAEVCPA-Q--EGSPEQDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVSIPSCCVSFATA-TEPSPIYTHVIENTDSPIWNFQ
QQSRLSKELLLDPHQALVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLLHLKEERQARRGTAAPDS-LIPLFSH---FSIPASSMCDTFPGP
IERHIQGQLAHTSPEEVDFSSL-----A---RNGTIRSQAARHEEHVQNIRRFHESLQ-H
GEAVLASDEKLATVPLS-SQTSILTSLRKNLSELDEIQKYFTQKLSKPFLPFSSHSSPAI
SKSLESQRDYVGPET--S-SRDP---ENQCILEKSSNLVMQVSSLISDLQTIT--RDS-Q
AALASHQAR---SRSRTVTTLPDAQDTEALQGRSTTPE--EPLARAGEASTNSLPAPVLE
EISEG-GGLLHELVEHAVPITRVQR-------------------S---DDTEVDPELSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFTSDMSGEVISPQPNEVQREGSSCP-PGPFPR-
EELKVRSSLMSSPQKAV-----------NPQ-AGRGSPSHS-IACEGGAYKTKVE-ESA-
SAQPLLVPGLTVSGAKESNDSVGWG-SP--QKKQDKRPMPEILAERET------FSS---
-------------EFSDS-------------SESF-EKF--PLYLPSQSKRENLKEPPMD
------------------------SPSVRQEQVTTGPGM-STRQSL---LLPEPIVVPNF
FLPPQQLEASLRMISHSPALPPPATTDQDKSETTRGAL---------AQRPCRPRPNSL-
-------PSNFPEEETRR---IARI--FSSHYSQKPGEA---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRRRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKVVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYNSYHPLPTTDMTEDVLLSKQ
VFRENTEPSSTPFLVPSRP---PDIHTIKIDGKELAANSS-RSTTP---RGRDHVYFAEN
PDTIKDSFFGLQHHLNSGQSLE-----SVTLKGKSP-RKQTSLLNSSEFQPQIRTVAKSR
SDSCISSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMF-LDQVHPPMKEDSLR
AS-T------------Q-IRT-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNNWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDTSVS
DFLSEEDDIVPSENMNQSKALARSSKLLESGDHKLKKR--------SAGRRNRNL-----
VEQQMLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-APGKKNYAGPP
PKLTT--------AKKRTFFVEYHFPVGFSESRLGKTALITEVVRLASSKITDXXXVKFQ
QRFVFPVQFGDPMIDHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSDLLSFSDQ
LPVQQEND---QTPFGPLKVTMELVTDNKDFTGVNSKLS-GNTHYTPLCAPTSPNKALPE
LNQDKTC---------TKNPQNLNQIHEETAKKAQNLVLPSQKSPSPIAPYPS-TFMAMP
ASRNLVNQTNKSTIESALLLHVLLMVPDGKDFIIGESEKQPPCNVYLNCKLFSTEEATRS
VIAWGTTQPVFNFSQ---VIPVSLSSTYLERLKNNVMVIETWNKVWSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PSFSRRPAHFLDQRT-VASVAMAEDRGNGLMEHCFEICVKMLQGLTTF-
--QATVWGEADCYIQYHFPVQHSQSGVQKGPEFPENGITLKPFRTATTLCVPDPIFNSDH
HHSLLLPAEVPVQRLLLSAFSAQGIVPGGGVQFEVWYRYYFPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTSMIEDRKELRN-QSSGFLDVIL
RYRRSPRTAGGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKVLAEQEPALQFSATVGVNASVTTHL
SFLPQEKQRRTRPVACSFCPEFSHHIE--FTCNLVTQHCSGEACFLAELLEFAEVVF-AV
YHENTKSAGDIISIQSCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPENGGLPHGLE
LMQRIVGGLELSVSFTHPGERERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYNFYDHEAFWTPLKKPKESVNKKQMV
VTFKASKRAEVTRGPSLLWYLREERLEIQVWRAYGNAS-VERPHQTDSWIGSAYVDLARL
GERSAKTLTVSGVYPLFGQNASNLSGAALRVHVVLSSL---SSHPDPTHE-LDSMDCSSH
SESEQLPRRN-DEVQFSPPVEVSCHQKSPTSTQVPCGSTTAEVCLT-Q--EGPAELDR-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFKEEKQARRGVETSGS-LIPVYSP---FSFPASNMYAALSSH
MARQTLDQLTHISSKELDFSSP-----A---RSGITRSQASRHEEHVQNIRRFHESLH-Q
GESLLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTHMAI
SQHQESCRDHPGSGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQYTEALQEQCTTPD--EPLARAPDKGTDSPPPPALK
ETSYG-GRILHESLSHTVPITKMQI-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-EVISPQPDEVQREDPSCPSLGPFCR-
EELTVKNSFLSSPERAV-----------KSHLPRQGSPSQSLVACEDGASKANVGGESA-
STNPRPLPCLTLSGAQQSSTFVGWS-SP--QVDQNKEPQSEAPAENEP------ATS---
-------------ELSNS-------------ADSF-KML--PVNLAPQSRRENHKGPPIN
------------------------SSDIRQRQMTTGSET-SAKQSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSKATTGAL---------SHRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQVPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-ASVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKFDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPASKKLGELQVSLALEPLSETYDSYKPLPATEVTENVLLSER
ELRENAESSNNQSRIPSG---SYRVPAIKTDGKELAGNSS-RSTTP---RGKDHLYFAEN
SDAVKSSSCGPRHQLNQGTNVE-----TVTLRGKAP-QKQLSLLNRSEFQPQINTVAKSH
SDSCILSSNNPPTKDLLSALLEQGSRLRNAMLISAMNTSPDTSML-LDKVPPPVADDVSR
SP-V------------L---N-SPTNQCKGHREDHLLPLVD-T-----------RAIQLL
LGSAELSQSHCWNGLGSPPDSPAPGSDVYCSSDLNDPQYDQSLLENLFYTV-PKSDVGAS
DFLSEDDGLEPSKTMNQSKASDRS-KVEGSREQKLKKR--------AAVKKSRN------
-------------AAMSLSVDRLALLGRVHAVRIIIEAMGVPPDSPHA-TPSRKIFAGKP
PKPAAA--------KKCTFFVEYHFPVGFSKNGLGKTALITEVVRLASSKISDG-VVKFQ
QRFVCPIEFGGAMIEHWWSSNLTFQVYAKKTPQKKPEAVGSASLPLRAVLESELLAFSRQ
LPVQQENG---LSSLGPLKVTMELVLGNKDFTGISAKLR-RSTQPAPPSAAASLDAVLPE
TGQGTACTNSTTCTTCTNSPQSPNKIHKETTKKTQNLVFPEPESASSVASNSS-AFMVMP
P-SNLVPQVNGSAKEDGLLLHVLLMVPDGKDFVFGEPEK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNVYLNCKLFSTEEVTRS
VVSWGTTQPVFNFSQ---VIPVSLSSKCLERLKNNVMIIETWNKARSPGQDQLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVAMPEKQGAQLVEHHFEFHVVMVKGLMPL-
--QATVWGEADCYVQYYFPFQDSQPSMLQGPALLENGITLKPFRTSTTLCVPDPVFNSQH
HHSLLLPTEVPVQRLLLSAFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRISAMVTMQ---HREDIGTQNFNLPLTPRLEPSKELKS-QSSGFLDVSL
RYRRSPRTAEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSAAVGVNASVTTHL
SFLPKGEQRQTRPVACSFCPEFSHHLE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDITRIQSCKNYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDEGLHQGLE
FMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----DTPKDLVKMEEE---V---P
ATVTISTPRLWLPLHCVLLAGHKNIHKNTYCYLRYKLYNQEAFWTPLRKPKEST-DNQVL
VTFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPHQTDSWIGSAYVDLSRL
GEKSTRTLTVSGVYPLFGRNASDLSGAALRVHVVLSPF---FPHSEPSRE-LDSMDCSSH
SESEQLPRKS-DEPQLSPPC---VLQKSPASTQVHGNSTAADVCPS-Q--QGPPELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTDRKVSVPSCCVSFATA-TEPSPVYTHVVENTDSPIWGFQ
QQSRLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPMESLMHFKEERQARRGIETPGS-LIPMFSP---LSFPASTVCDAFPGP
MARHIPGLPAHAAPE-EDLSSP-----A---RNGTIRNQAARHEEHVQNIRRFHESLQ-H
GEAVLPSDGKPTTVPST-PHTSILTCLRKNLSELDEIQKYFNQKLSKPLLPFSSQSSPAV
SQSQESQREPVSVRT--S-SRDP---ESQCILEKSSNLVLQVSSLISDLQTIT--RDS-Q
AALTSHQAR---SRSRAVATLPVARDTEAVREGSTTPE--EPLAGAIEASPESLPPPAEA
P--SEGGGMVRESLEQTVPIMRVQS-------------------S---DDTEVGPDYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDMS-EILSPQPNEVQREGPS---PEPFPR-
EELKVRS----SPQKAL-----------SPH-SAQGSPSQS-VFCEGGAYEIKVE-DLA-
STKPQLVPSLTFSEPQESTDCVEQY-PP--QVNQGKKPTPEILAESEA------FSS---
-------------EFSDS-------------SESF-EKF--PLHLPSQSKREDHKKPPMD
------------------------SPAVRQKQVTTGSEV-STRQKL---LLPEPVVVPNF
FLPPQQLEASLRMISHSPALPPPATADQDKSEATTGAL---------AQRPCRPRPYSL-
-------PPNLPEEETRR---IARI--FSSQYSQKTDEA---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKAQGPGAGRSRGK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-ACVLVRVRWWGETSEGT
IFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLEHLPVGRVQISG
LAQLSPTHHISGFFAIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTADVTENVLLSEQ
GVREYPKASNTQFLVPSR---PHRIPTTKTDGKEA-ANSS-RSTTP---RGKDHLCFAEN
SDTTKHSSLGPQHHLNSGQSLE-----SMTWKSKAP-QKQVSMLNSSEFQPQIRTVAKGH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LEEVHPSMKEDVLR
AST-----------------A-LSGNQFEDHIEEHLLPTTE-----------NTGAIQLL
LGSAELSQGRSWDGLGSPPDSPSPGSDVSCISDLSDPQYDQSLLEKLFYTV-PKSDSSVS
DVCSEDDGVVPSKTMSQSTAPASARKVLESADPKLKKR--------AVGRKNRNS-----
GRC------PS----DDTKCDRLALLGRAHSVRIIIETMGVPPESPQE-TPGKKNFAGRA
PKPTA--------TKKRTFFVEYHFPVGFSKSRLAKTALITEVVRLASSKITDG-T

PF00168 // ENSGT00510000048072_0_Domain_0 (777, 833)

VKFQ
QRFVFPVQFGGPMIEHWWSSSLTFQIYTKKTPQKKPEVIGSASLPLRAVIQS

ENSGT00510000048072_0_Linker_0_1 (833, 1002)

ELLSFSDQ
LPVQQENG---QTALGPLKVTVELVIDNKDFAANNTKLS-SNTHHPPLCALSSPDKTLPE
PSQHVTG---------TKSPQSLNQIQEETVKKTQNLVLPTPKSPSPVVPNSS-TFMAVP
ASHDWINQISGSASENALLLHVLLMVSDGKDFMTGESEKQP

PF00168 // ENSGT00510000048072_0_Domain_1 (1002, 1083)

PCNVYLNCKLFSTEEVTRS
VIAWGTTKPVFNFSQ---VIPVSLSPSCLERLRNNMMVIETWNKVRRPGQDKLLGLVKLP
LH

ENSGT00510000048072_0_Linker_1_2 (1083, 1400)

QFYVSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGHQSGSLRVLLAMGSSEQITAV
QRLKNEEGTF-PPFSPRPARFLDQPS-VPSVSMAGDQGNGLMEHHFELRVDKVKGLAPL-
--QAAVWGEADCYVQYYFPVQDPQAGAPKGPEFPESGLSLKPFRSAATLCVPDPVFNSEH
HHSLLLPRDVPVQRVLLSAFSALGLGPGGGVQFEIWCRYYYPNVRDQM------------
-VARGTLPL-SRICALVTMQ---HREDVGAQSFNLPLASRLEDK---------SLLDVDL
RYRRTPRSAEGVPAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRQTRPVACSFCPEFSHHSE--FSCDLVTQHLGGEACLLAELLEFAEVTF-AV
YHEDTRSASDITSIHSFRDYLL-GVVKIPTKELLMKR-SGISGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

ILVPEEGALPHGLE
LLHKVVGGLELSVSFTRPGDRERVLEAAEPLGWTFE----NHLKDLVKVGDA---E---P
ATVTISTPRLWLPVHCVLLAGQKHLHKDTYCYLRYKLYDHDGFWTPLRKPKESANRKQVM
VTFKASKRAEVTRSPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWVGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHPGPPHE-LDSMDCSSH
SESEQLPRGN-DETQLSPPR---GRPKSPASTQVPCSSSSTAGVGPAQ--EGPAELDG-T
FAASVL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVSVPSCCVSFATA-DEPSPVFTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-GEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMRFKEERQARRGVKTPGS-LMPVHSP---FSFPASDVLATFPGC
FAGQTPERVAHTSS-EADFSSP-----G---RSGTARSQASRHEEHVQNIRRFHESLQ-Q
SEAVLPSDNRLPASPLS-SHASILTSLRRNLSELDQIQKYFSQKLTKPLLPLSPPTPEAI
LQCQESQRDHLQPG--AS-SLAS---DSQCLVEKSNNLVLQVSSLITDLQNIA--RNS-Q
GSLSPRRAR---SRSRGVSTLPDTQDAAAVQDQSTALD--LPVAGAPDEGPNAPPPPPVE
AASGG-RGLPPGSPGHTGPMTRMQS-------------------GEDPGDPGASPACSDE
DYEEDLVEPRTLNEVTTVTDRTSPWSSFTSDAS-GILSPEPDEVQRKGHSRPS-EPFRR-
EELDVR-------KRAV-----------EPPLPGPGSPGQSLVPREGEASEAGVG-GPV-
SAAPLLSSRVTLSGAQQSESCVGWN-SP--KADQAQEPTPEAQSEEEV------ASD---
-------------ELSDS-------------GESS-EQF--PLCPTSQSRRETHE----D
------------------------CPDIRQRQATSGSEA-STRHSL---LLPEPIVVPNF
FLPPRQLEASLRVLSLSAALPPPAATDQDKSEATKGAL---------SPRPCHPRPNSL-
-------PPTLPEEETRR---IARI--FSSRCSRKEPCSPGD------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRRGQGPGGVRGRRKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLIRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPVGRVQIGG
LAQLSPTHQINGLFTIVSPTSKKLGELQVSLALEPLSETYNSYSPLPTTDMMENV----Q
GFRENTEPSNTHFLVPSRP---HRMPTVKIDGKELAANNS-RSSTP---RGKDHMYFAEN
SDMIKDSFFGLQHHLKSGQSLE-----SVTLKGKAP-QKQMFLLNSSELQPQIRTVAKSH
SDSCILSSNKPPTKDLLSALLERGNKLRDAMVISAMKSSPDMSML-LDKVHSPIKEDSHR
AS-A------------Q-IRS-LFRDQI----KDHLLPPTE-NTFWKSDPKADTRAIQLL
LGSAELSHSHFWNGLGSPPDSPPPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSETSIS
DFLSEDDDIASSKKMNESKTLARSSKVLESSDHKLKRK--------AAGKKNRSL-----
VEQQMLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TSGKKTFAGRP
PELTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVARLASSKITDG-VVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKMPQKKPEVIGSASLPLRAVIQSELLSFSDQ
LPVQQENG---QTLLGPLKVTVELVTDNKVFTGVNTKLG-SGIQHTPPCAPISPDKILPE
PSQDITH---------TKNPQNLNQIHEETAKKPWNLVLSNSKSPS---TNPS-TFKTMP
TSHNLVNQTNGSTKENDLLLYVLLMVPDGKDFITGESEKQPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNIYLNCKLFSTEEVTRS
VITWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGNLRVFLAMGSSDQIMAV
QRLKNEEGTL-PHFSPRTAHLLDQPS-VAAVAMAEDQGNGLMEHHFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEILENGITMKPFRTSTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSAQGLMPGSGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---RREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRHSLRTAEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKVLAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTHPVACSFCPEFSHHIE--FSCNLVTQHCSGEACFLAELLEFAEITF-AV
YHENTKSASDIASIQSCKDYLL-GVVKVPTKELLAKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1869)

VILPEDEGLSHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NSLKYLVKVDEE---K---Q
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKLYDHEAFWTPLKKPKESANKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPPPEPSHE-LDSMDCSSH
SESEQIPRRN-DEIQLSPPC---DHQKSPASTQIPCNGTTTEVCPA-Q--EGPAELDG-T
FAVSILVE

PF00168 // ENSGT00510000048072_0_Domain_3 (1869, 1974)

RAMHLSLKGSPLMERKVSIPSCCVSFATA-DEPSPIYTQVVENTNSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQARRGAETPGS-LLPIYSP---FSFPSADVRVTFSSN
IARQTPNQLAHISSKELDLSSP-----G---RTSTTRSQASRHEEHVQNIRRFHESLQ-Q
GEAILPCDDKLTVSPLS-YHTSILTSLRKNLNELDQIQQYFSQKLTKPFLPLSPQTHTAI
LQCQESCRDPGGPGA--G-SLDP---ESQCILEKSNNLVLQVSSLITDLQTIT--RNS-Q
AALSPHRTR---TRSNKVTTLPDTQDTEVMQERSTTSN--KLLARAPDEGTNSPLPPALE
ETSNG-EGMLHKSLGHTVPITRMQS-------------------S---EDTETGLAYSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFVSDTS-EVISPQPDKLQRKDPSCTCPDPFPK-
EELKVRSSFLSIPERAV-----------NPHLPRQGSPSQSLVACEGGASKARVG-EPI-
SANPQLIPRLTLSGAQQSNTFVEWS-SS--RGDWDKEPKPEAQAENEA------ASS---
-------------ELSDS-------------ADSF-EKF--PLHLASQSRREIPKGPPIG
------------------------DCDLSQKQVTTGSET-SKRQS----LFPEPV-MPNF
FLPPQQLEASLRMLSLSAALPPPATTDQDKSEATRGAL---------SRRPCRPRPNSL-
-------PPTLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKAQGPGGGRSRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLSVNKVIWKIAKPP-ACVLVRVRWWGETSEGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLEHLPVGRVQISG
LAQLSPTHHIDGFFTIVSPASKKLGELQVSLALEPLSETYDSYNPLPTT---ENVLLSEQ
GFREYSEASNTQFLVPSR------IPTTKTDGKDLAANSS-SSTPP---RGKDHLYFAEN
SDTVKDSFSGLQHHLNSGQSLE-----SVTLKGKAP-WKQMSLLNSSEFQPQISTVAKSH
SDSCVLSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LEEVHPSVKEDFLR
ASS-------------Q-IKA-LSRNQDKDHIEGHLLPPTEK-----HDTKADTRAIQLL
LGSAELSQGRYWDGLGSPPDSPSPGSDVYCSSEPSDPQYDQSLLENLFYTA-PKSDTSVS
DIFSEDD-DVPSKTMSQSKALARSPKVLESNDHKSK-K--------EMGKKNRNL-----
VEQQMLSKTPEDAQVMTLSVDKLALLGRTHSARIIIETMGVPPDSPQD-TSGKKTFPGRP
PKLT---------SKKRTFFVEYHFPVGFSKNGLTKTTLITEVVRLASSKIIDG-VVKFQ
QRSVFPVQFGGPMIKHWWNSNLTFQIYTKKAPQKKPEVIGSASLPLRTVIQSELLSFSDQ
LPVQQENG---QTPLGPIKVTVELVLDNKDFTGVNTELS-SNTQHTPLSALTNPDKTLPE
TVQDVTC---------SKNPQTLNQTYEETVKKMQNLMLPTPKSPSPFIPNSS-TFMAAP
ASHDLVNEMNGSTEESALLLHVLLMVPDGKDFVTGESEKQPSSNVYLNCKLFSTEEVTRS
VIAWGTTKPVFNFSQ---VIPVSLSSKCLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKVSRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLRNEEGTL-TPFNPRPAHFLDQPS-VASVAMAGDHGNGLMEHHFELLVDKVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSNVLKGPEFLENGITLKPFRSAATLCVPDPVFNSGH
HHSLLLPAEVPVQRLLLSAFSAHGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICALVTMQ---HREDGGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRQTHPVACSFCPEFSHHSE--FSCNLVTQHCSGEACFLAELLEFAEVTF-AV
YHEDTKSASDITSIHSFKDYLL-GVVKIPTKDLLMKRSEGITGWYPIVFPEEGGLPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAKLLGWSFE----NNLKDFVKMDEE---E---P
ATVTISTPRLWLPTHCVLLAGHNHIHKSTYCYLRYKLYDHEGFWTPLKKPKESTNKKQVM
VTFKASKRAEVTRNPSLLWYFREERLEIQVWRAYGNES-VERPHQTDSWIGSAYVDLTRL
GERSARTLTVSGIYPLFGRNASNLSGAALRVHVVLSSL---SPHPGPTHE-LDSMDCSSH
SESEQVPRGI-DEIQLSPPH---GHRKSPASTQVPCSNTTAEVCAA-Q--EGPPESDG-T
FTVSILVERAMHLSLKGSPLTQ

PF00168 // ENSGT00510000048072_0_Domain_3 (1883, 1952)

RKVSVPSCCVSFVTA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFKEERQARREVENPGS-LIPVYRA---FSFPASAVYAAFPGH
TVGQTPELPAHPSSKEADFSSP-----G---TSGSTRSQTSRHEEHVQNIRRFHESLQ-Q
AEAVLPDADRLAASPLS-SRTSILTSLRRNLSELDQMQRYFNQKLTKPLLPLSPQMHTAI
LQCQESQTDCLRPA--AS-SLDP---ESQCILEKSNNLVLQVSSLITDLQTLT--RNS-Q
GSVSSHQAR---SRSREVTTLPDAQDRGTMQERSTSPD--LSLARAPDESRSSPPPCALK
ETSSG-RGKLHEALEHRIPITKMQS-------------------TEDT---EAGLAFSDE
DYEEDIVEPRTLNEITTATDKTSPWSSFMSDAS-EGRSPQPDEAQREGFSCPS-ESFPR-
EELRVRSSFLSSPERNV-----------DAHFHRQGSPSQSTVSCEGVLSKARVG-EPA-
SADLQLTSHMTLLGGQQSDTCVGWH-SP--KANQDQGPKPQSQAKKEV------ASD---
-------------ELSDS-------------ADSS-EKL--ALQPASQSRRENHKEPPIT
------------------------CPDIRQKQTTSGSEV-STRQSL---LLPEPVVVPNF
FLPPQELEASLRMLSISAALPPPATTDQDKSKATRGSL---------SQRPCRPRPSSL-
-------PPTLPEEETRR---IARI--FSSQFSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MGVLVLEVLTKLDHLPLGRAQITG
LSQLSPSHPIKGSFAVLSPTSEKLGELQVSLVLEPLPELYDTSSSVPTAEGTSDAAAAQG
SSKPQ-------PPAPS-Q----PRHTQVTAEQEPV--DSSKATT---LRGKDHLLYQEN
SENMQDT---FSAP------RARVILPDERLRPNPW-DQLLPFPSSTDPEALP------S
RKARVLSMHNPAPKDLLSALLDQGSKLRDAMVVSAMKSSPDMEIK-LNKISHFIETDDFK
A-------------PTKSPKG--LKSSFVPTPEDSHHLGSE-VSGQQFGLNSEERAIQLL
LGSADCSPGHLWDQTGSLWDSLSLGSEVY-DSELGDPHYDQSLLERLFYTA-PKSDSSLS
DFLSDDD-IKSSKKASKTETLEKAGPVNPQKD-----FPAF--DQNVTETKPSCSPSAPR
E---DPRE---MALLTPLGADRLALLQQIHLARVTIESLRIPSES-IQISPRRKGLLGKP
PRPMS--------VHKCTFFVEYHFPVRVSKDDEGQVSITTEAIRVASSKITDN-VVKFQ
QRSVFPVWFGGTMIEHWWGSDLAFKIYMRKSTQKKPVAIGSAALQLRRVIEAELLSVSLE
IPVEKEGD---HTQVGPLKVSLQLLASSKDSACSAR-----------SGTAGSAQLGLRE
PSRTSAS---------AESPVSPRRSPEESQEAGG-------GGRDVAQ--PP-HTVLAP
AAQDVATRTAP-AQEPGLLLHVLLMVPDGRDFTAGACGLPS

PF00168 // ENSGT00510000048072_0_Domain_1 (1002, 1057)

ACNVYLNCKLLSTEEATRS
AVVWGTAQPAFNFSQ---VMPFTLTPKHLERLKNNV

ENSGT00510000048072_0_Linker_1_2 (1057, 1400)

MIIEAWNKLGSPGCDKLLGLVKLP
LHQFYISFKDPRVSQLLLQAQYPVVAVDGHVPVVDVFTGSTSGSLRVILAMGSAEQIVAL
QRLKTEEGMV-PPATQRPPHSLDHPPSTKPTMQLDAEGEDLVEHVFEIRVEGVKGLTPL-
--QSTVWGEADCYVQYHFPVQEPGCGALQAPGGHQDGITLKPFRTATTLCVPDPIFSDEH
HHSLSVPADVPVQRLLVSAFVAPGA-AGGGIQFEVWCRYYYPNVRDQL------------
-VARGALPL-SRLCAMVTLQ---RREEIGIQTFNLPLVPRTDSSGEFQL-RSSGLLDVSV
RYHRSVKPAARI-TAQAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1471)

LSVQIHRAAGLQAAARAVAQQHPRVQPCAGVGVNAYVRVLP
SFLPRAQARRTPAVPCTFCPEFQQHLQ--F

ENSGT00510000048072_0_Linker_2_3 (1471, 1887)

LCQLTTHESSGQASSLGELLQSASIFF-SI
YHQSTKSATDKLADRTSRDYLL-GTVRIPTRDLLTRR-SGISGWYPVTLSEDPPPPRCTS
PAPAVVGGLELSVAFARQGDRERVLEAARLLGWSSEEV-QDSED-----ESAGWGQGGSP
VAVTVSTPRLWLPLRCVLRAGQAQLHSSTRCYLRYKLYDQHATCTWLKRPRLSDDAQSVT
VNFRKPSKVTLRRSQGLLWFLREEKLEIQVWWAYGKESEVERPLDTDRLIGSAYVELAAL
AERSQGTLSVSGVYPLFRCNAADLAGAAVRVHVSLAPT---P--AA-LPR-APCAEECSS
SEDEGPGETPALNQHVSDK-----QQVEAGSSGVTSAE--------PQE--EDAMFLENT
VAVNILVERAMHLSLKGSPLTEREVA

PF00168 // ENSGT00510000048072_0_Domain_3 (1887, 1950)

APSSCVSFAVA-GADAPVTTPVVENTDSPVWDFQ
QQARLSKELLLDPQQTLVFKVWHKA-ESERVIGFASVDLSPLLSGFQLVCGWYNISDFSG
QCRGQIKVAVSPLQSVGHLRGERRARARSQPDSS-----SVK---VSFPA------CPSG
PANLSK-QMLNSSSKEVGV--------PSLERRSPPGTRRARHEEHVQNVRRFHESLQ-Q
AEGSARRAAGPE---PA-PRAALLSALRKNLSELDEVQRYFSEKLTRSFPDFST---SKP
S-HEEWESDHQGSM---SREVDP---KGCHLLEKSSQLVSQVSSLINDLQTIT--KNS-K
EASDVHLDS---ARKQGAVDAPRWKEEGASP-GVAG----QLESDAPRVSSDTQQPCSTG
TSVFD-RHMLHQLLGPLVPEDEH--PVG---------------CSQEDEGAIAIQPHSEE
EYEEDVIEPRTLNEITTVTDRTSPWSSVVSETGQGAE-QHPLDPRPEEQHSTDAGRFQR-
-GNGST---LSSMLQGDSQSVLSALSPPVSPHAAGNSP----WAAAGDFQTFRSS-----
-T------GTAEKELHPPAGHSLWSRAL--STDPIKRS-----VEFHA------GSEELQ
PFPGDRGLTNGKTTERG----------EEENAEVV--------N-GDHQSK--------E
GSGSDENCVQSVSAQAGSERNSESFPDDSSEDPVEGSEN-SIKPKM---PLSDPVVVPNF
FLPPQEMEASMRLLSTSSHPSTSPESRSGAVPVPGGIP---------YRRANRPRPSP--
---------GLSEEETKR---IASI--FSAQLSKRE------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGHKKT-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPS-TSVLVRVRWWGETSDGT
LFYPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMSVLVLEVITKLDHLPVGRVLING
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTTDVTENMLLSEQ
GLRENTESSNTQFLIASKS-F--GEPTAKTDIKEL----------------ADHLYFSEN
SDTVKDSFLRLQHHLNSGQSLE-----SVSLKSKAP-QKQMSLLDSSKFEPQIRTVAKSH
SDSCIPSSNNPPTKDLLSALLEQGNKLRNAMVISAMNSSPDTNML-LNKVYAPIKEDFFR
SS--------------Q---S-SSKNQFKDHSEDHFLPLTE-NT----------FSIQLL
LGSAELSQGRFWDGLGSPPDSPAPGSDVYCSSDLNDPQYDQSLLENLFYTE-PNSDVSVS
DFLSEDDGTEPSRIMNQSKAFGRSSKVVEPSECKLKKR--------GAGKKSRNL-----
VDQQVLSKTPGNTQVMSLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TSGRKALSERP
PKPTTA--------KKRTFFVEYHFPVGFSKSSLGKKALITETVRLASSKIMDG-VVKFQ
QRFVCPVQFDGSMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQENG---ETSLGPLKVTMELVISNKDYTGVSAKFS-SSTQHTPLCVTTSPDKRLPE
PSQDTAY---------TKSPQNSNQICEETAKKTQNLVLPSPKSPNSIVPDSS-VFMAFP
ASHNLIHQKNGSTKENALLLHVLLMVPDGKDFVTGESEKQP

PF00168 // ENSGT00510000048072_0_Domain_1 (1002, 1084)

ACNVYLNCKLFSTEEVTRS
VISWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVQSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISHLLLDAKYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQITAL
QRLKNEEGTL-PPFSPRPVHFLDQPP-VASVAMAENQGNSLMEHHFELHVVMVKGLAPL-
--QATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSSQGLVPGDGVQFEIWCRYYYPNVRDQM------------
-VARGTLPL-SRIYGMVTMQ---YREDVGMQNFNLPLTPRLENSKELKN-H-SGFLDVGL
RYRRSPRTTEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTSHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVSDIASIQSCRDYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1865)

VILPD-ESLPHGME
FMQKIVGGLELSVSFTRSGDRERVLEAAELLGWSFE----NSLMDLVQIQ-E---V---P
ATITISTPRLWLPVHCVLLAGHKNINKNTYCYLRYKLYNQEAFWTPLRKPKDSTNKNQVL
VTFKASKKVEVTQSQSLLWYLREERLEIQVWRAYGYDS-VERPHQTDSWIGSAYVDLTRL
GEKSTKTLTVSGVYPLFGRNASDLSGAALRVHVVLSPV---SPHTEPTHE-LDSMDYSSH
SESEQCPRRN-DEIQLSPPN---GLQKSPASTQIPCNNTTAEVCPA-Q--EGSPELDG-T
FTVS

PF00168 // ENSGT00510000048072_0_Domain_3 (1865, 1974)

ILVERAMHLSLKGSPLTERKVSIPSCCVSFATA-TEPSPVYTHVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNIMDFSG
ECQGQIKVAVSPLESLMHLKEEKQARRGAETPGS-LIPMFNS---FSFPPSNMCATLPSP
IARHAQDQLAHTSSKELDFSSP-----G-----STIRSQAFRHKEHVQNIRRFHEFLQ-Q
GEAVSTYDEKPTTVPLS-SHTSILTSLRKNLSELDQIQHYFSQKLSKPFLPFSSHSPPII
SKHQESHRDLKGSGS--S-NLDP---EGQCILEKSSNLVLQVSSLISDLQTIT--RES-Q
AALTSHQAR---SRSREVITLPDAQDTEAVQDQSPTPV--ESLARAVEASTNSPPPPVLE
KTSSG-GRVFHESLGHTVPVTKMQS-------------------S---DDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDTS-EIISPQPNEVQREGPICP-PGPFTR-
EKLEVRSSFLSSPQKEV-----------NAHLPGQGSPSQS-IACEGAQQNNV-----F-
VDKPQLIPHLTHSGAQQSNAFVEWS-SL--QADQDKKVMPEVQAESEA------SSS---
-------------ELSDS-------------ADCF-EML--SLHLPSQSKKENLKEPPRN
------------------------SPAIRQKQVTTVSEV-STRQNL---LLPEPVVVPNF
FLPPQQLEASLQMLSHSPALPPPATADKDKSEATKGAL---------FQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSKTDEA----------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MRQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTPKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIVETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEIIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISHLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEIPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQV------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRCSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQRCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRQRVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
RERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPLEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCKDHLGPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDAQDTEALQERCTTPH--EPLARAPDKGTDSPPPPPLE
ETSNR-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDAS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVGCEGEASKAKVSGESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATSPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PTNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGPATGGSRSRKKKG
NPREGLSDISPSTSLPPLVEGQLRCFLRLTISKILWIVVKPP-TPVLIRVRWWGETSEGT
IFCPRDASIIEQKAVRTTTRYAIRCGPKQFTSYLTDMNVLVLEVITKPDHLPVGRAQISG
LSKLSPTYPISGFFTIVSPTSKKLGEIQILLALEPLSATFDNCSSF-TTDVSGDVPLLDR
GFRENTEPNKPQLSEMAQ---SHKLPVTNTGGKESL--TSSRATTP---RGKDHLYFPDN
S--IVDSFLEPQPHLNSKQLLE-----NETVEQEPV-KKQVSCPTISVCDPHIRRVAESQ
SDFQVQSLSNPPTKDLLSALLEQGNKLRNAMVVSTMQSCPDTNIL-TQVPPSPRKPALKS
SAHVKLSSGICP----K---N-PVITETMHRVKDPLLPPTQ-SIIQDHDHEVDTRAIQLL
LGSANMAPGHSWDGLGSPPASLSPGSDAYCSSELNDPQYDLSLLESLFYMT-VKTDSNVS
DIHSEDDDKIPPEKLVQSRDIAQHPKAVDSRHHSRKKT--------AMGKKPKSS-----
TVQPTCSESPRKNEVITLSLDRLALLGRIRSARVVIEALGVTPESPQATTPGKTSIPSRP
PRSNS--------SRKRTFFVEYHFPIDASRTETEEILVATETIRLASSKITGG-VVKFQ
QRYVFPINFDGAMIEHWWKSDLTFKIYMKRNTQKKAELIGSALFPLQEVICSQHLSFSGQ
LPMEEKS----QTSIGPLKVSVQLAGDNRDVSSTNSKTL-SGTQQPPVCVPTSPVKQTLG
GGQSATS---------GKNPQALTHVNEETSKQKQYLGHWSPDPTCPTGPKLS-VPTALS
SFHSTGILMNKSTQEKPLLLHVLLMVPDGKDFVTGTSEKQQTCNVYLNCKFFSTEEVTRS
AIVWGTTEPTFNFSQ---VTPVTLTPKYLERLKNNVMVIEAWNKVRNPGQDKLLGLVKLP
LHQFYISFKDPKISQLLLEAQYPVVAVDSYTPVIDVFTGHQNGSLRVFLAMGSANQITAL
QRLKNENGSD-PSYSPRPAHFLDQPP-TSPVMQRDGQGDGLIEHQFEIHVEKVKGLIPL-
--QSTVWGEADCYVQYCFPVQDSEKSTLKGIKLPESGITLKPFRSATTLCVPDPIFNHKY
LHSLLLPPEVPVQRLLLSAFSMCGLVPGSGLQFEIWCRYYYPNVREQM------------
-VAKGSLPL-SRLCAMVTLQ---HHENIGLQTFNLPLFPKSENKDEFQA-QTAGLLDVSL
RYRHTTRTTEGVIAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1472)

SVHIHRASGLQAAARVMAEQEPSLQYSATVGVNTSVTTHL
SFLPKGEQRQTRPVARTFCPEFSHHME--FP

ENSGT00510000048072_0_Linker_2_3 (1472, 1885)

CNLVTQHSTGEACFLAELLEFAEIIF-SV
YHQDTKSSSPPDRIQPLREYLL-GVVRIPLKDLLIKR-SGITGWYPVILPEDLASKQNTD
IMQVIVGGLELSVSFAHSGDRERVLEAAKLLGWNFEESPAD----LLTDV-EEW-----P
ATVTISTPRAWLPTHCMLLAGQTHIHKATHCYLRYKLYDQEGFWTSLRKPKLTMDEKQAT
VTFTTTKKVDVNMGPSLLWYFREEKLEIQVWRSYGNDS-VERPHHTDTLIGSAYVDLSRL
SERTAKTLTISGVYPVFGRSASDLSGAALRVHVVVTAERSVSFQPWPAHQ-PNCNEYSSN
SDSEKIPSQQ-DPEDPEN---------QSDSKKPSYSEGPSTKSVPIE--ADIVDLEG-T
FAVTVLVERAMHLSLKGSPLTERN

PF00168 // ENSGT00510000048072_0_Domain_3 (1885, 1953)

VTVPSCCVSFVAA-DVRSPIYTPVIEKTDSPIWDFQ
QETRLSKELLLDSQQTLVFKVWHKA-EVERVIGFASVDLSPLLSGFQFVCGWYNIADFSG
QCQGQIKVAISPLESIIHLKEERLARHRAKVSGL-SIPKYSP---FSFSTA----AFPNY
IGRYTLDQPAQGCSKDIDMSSP-----R---RSGPLRSQASRHEEHMQNVRRFHESLQ-Q
AEGIIQNDSQRDSLAFS-SRNSLLSSLRKNLNELDQIQRYFSQKLTKSYPQLTFSLSAQP
Q--QDSGDNRQEAE---TGSPNL---GSHHILEKSNDLVSQVSALITGLQTLT--KDT-P
SLSSIHQMESQNLKGK---ALHGDHKVENDEERNALLQ-------------DQLSSFPLK
IPPPE-KKILGEFLDQEATENSLPLILEVVEIEKDSEVAQTLEVVDIEKDSEVAQTSSDD
DFEEDVIEPRTLNEITTMTDKTSPWSSITSEEN-VAVDHLLKEVKKDDLSISTSKHSPR-
KDQSDESKSHLSTQQDICLYPPDRTQACLTPTAET------DSVYGMGVD---MG-----
-K------------YHKNSKTTGLSQIGDTSKGTIFSLVLET-----SQQENLESESSYS
SDTGEFALHQANSVLQTGTSCLDENHGNKD--ISHSKKL--PTKLSSC------------
------------------------RRSEKPEVLLTESEK-SPKQNL---SLPEPLRVPNF
FLSPKHLEVSMRMLSLSAASPSI-TAHQGGSESTKSIQ---------SRRPGRPRPNPP-
-------PLNLPRKEAER---IAKI--FSAQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSATSKKLGELQVSLALEPLSETYDSYHPLPTSDMTEDVLLSKQ
GFRENTEPSSTPFLVPSRP---HDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSFFGLQHHLNSGQSLE-----SVTLKGKSP-RKQMSLLNSSEFQPQIRTVAKSR
SDSCISSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPMKEDSLR
AS-T------------Q-IRT-FSRNQFKDHIEDHLLPSTE-NIFWRHDTKADTRAIQLL
LGSAELSQGNIWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDIVPSENMNQSKALTRSSKLLESGDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETVGVPPDSPQM-VPGKKNYAGPP
PKLTT--------TKKRTFFVEYHFPVGFSESRLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIDHWWNSNLAFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQENG---QTPFGPLKVTMELVTDNKDFTGVSTKLS-GNTH-TPLCAPTRPIKALPE
LNQDKTC---------TKNPQNLNQIHEETAKKAQNLVLPSQKSPSPIAPYPS-TFMAMP
ASHNLVNQTNESTTESALLLHVLLMVPDGKDFIIGESEKQPPCNVYLNCKLFSTEEATRS
VIAWGTTQPVFNFSQ---VIPVSLSSTYLERLKNNVMVIETWNKVWSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PLFSHRPAHFLDQPT-VASVAMAEDRGNGLMEHCFEICVKMLQGLTTF-
--QATVWGEADCYIQYHFPVQHSQSRVLKGPEFPENGITLKPFRTATTLCVPDPIFNSDH
HHSLLLPAEVPVQRLLLSAFSAQGVVPGGGVQFEVWYRYYFPNVRDQI------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTSMIEDRKELRN-QSSGFLDVVL
RYRRNPRTAGGVLAARTVSISVQIIRACGLQAAAKVLAEQEPALQLSATVGVNASVTTHL
SFLPQEKQRRTRPVACSFCPEFSHHIE--FTCNLVTQHCSGEACFLAELLEFAEVVF-AI
YHENTKSAGDIISIQSCKEYLL-GVVKVPTKELLIKR-S---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------GSPLTERKV

PF00168 // ENSGT00510000048072_0_Domain_3 (1886, 1974)

SIPSCCVSFAVA-NESSPVYTQVIENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFKEEKQARRGVDTSGS-LIPGYSP---FSFPASDMYAALSSH
MARQTLDQLTHISSKELDFSSP-----E---RSGTTRSQASRHEEHVQNIRRFHESLH-Q
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTHIAI
SQHQESCRDHPGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQYTEALQERCTTPD--EPLARAPDKGTDSPPPPALK
ETSYG-G-ILHESLSHTVPITKMQI-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-EVISPQPNEVQREGPSCPSPGPFCR-
EERTVKNSFVSSPERAV-----------NSHLPRQGSPSQSLVACEDEASKAKVGGESA-
SANPQPLPCLILPGAQQSSTFVGWS-SP--QVDQNKEPESEAPAENEP------ATS---
-------------ELSDS-------------ADSF-KKL--PVNLAAQSRRENHKGPPIN
------------------------SSDIRQRQMTTGSET-STKRGL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSKATTGAL---------SHRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEIITKVDHLPIGRAQISG
LAQLSPTHQINGLFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTIDMTENMLLSER
GLRENTEPSDTQFLVPSRT---HKMLTIKTDGEELAPNSN-RSTTL---RGKDCLYFPEN
SDMIKDSFFGLQHHLKSGQSLE-----SITLKGKAP-QKQVSLLNSSELQPQIRTVAKSH
SDSCILSSKHNPTTDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDKVHSPIQEDPHR
AS-T------------Q-MRS-WSRNQFKDCIEDHLHSPTE-NTFWKNDTKADTRAIQLL
LGSGDLSRGHFWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSETSIS
DFLSEDDDIAPSKKMNQSKALVKSSKVLESSDHKMKKR--------AAGKKNRSL-----
VEQQILSEIPEDAQVMTLSVDRLALLSRTHSIRIIIETMGVPPDSPQM-TSGKKSSTGRP
PTLTT--------AKKCTFFVEYHFPVGFSESGLGKTALVTEVVRLASSKITGG-VVKFQ
QRSVFPVQFSGMMIEHWWNSNLTFQIYMKKIPQKKPEVIGSASLPLRAVIQSELLSFSDQ
LPVQQENG---QTQLGPLKVTMELVTDNKDFTSVNTKLS-SNTQHTPLCAPASADKILPV
PNQETTY---------TRNPQNLNLIHEEAAEKAWNLVLSNPKSPS---SHPS-TFKTMP
ASHNLEKQTNGSTKESALLLHMLLMVPDGKDFVTGESEKQPPCNIYLTCKLFSTEEVTRS
IIAWGTTQPVFNFSQ---VIPVHLSSKYLERLKNNVMVIEIWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISCLLLDAQYPVVAVDSYMPVIDVFSGHQNGNLRVFLAMGSSDQIMAL
QRLKNEEGIL-PPFSPRPGHLLDQPS-VSAVAMAENQGNGLIEHHFEIHVEMVKGLAPL-
--QTTVWGEADCYVQYYFPVQDSQSSVLKGSEFLENGITMKPFRTATTLCVPDPIFNSEH
HHSLLLPSEVPVQRLLLSAFSSQGLTPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTRQ---QRENVRIQTFNLPLTPRIESRKELRN-QSSGLLDVGL
RYRHSLKTAEGVLAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1472)

SVQIIRACGLQAAAKVLAEQEPALQLCATVGVNASVTTHL
SFLPKGEQRRTRPVACSFSPEFSHHIE--FS

ENSGT00510000048072_0_Linker_2_3 (1472, 1884)

CNLVTQHCSGETCFLAELLEFAEVTF-AI
YHENTKSAGDMASIQSCKDYLL-GIVKVPTKELLVKR-SGIIGWYPIVLPEDRGLSHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAEVLGWRFE----DNLKDLVKMDEE---K---P
ATVTISTPRLWLPIHSVLLAGHNYIHKNTYCYLRYKLYDHEAFWTPLKKPRESANKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQMDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNTANLSGAALQVHVVLSSL---SPLPEPTHE-LDSMDYSSH
SESEQLPRRN-DKIQLSPPC---SHQKSPASAQVSCNSTTAEVSLA-Q--EGPAELDG-T
FAVSILVERAMHLSLKGSPLTER

PF00168 // ENSGT00510000048072_0_Domain_3 (1884, 1952)

KVSIPSCCVSFATA-DEPSPIYTQVIENTDSPVWNFQ
HQSRLSKELLLNPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQARRGVETPGS-LLPVYSP---FSFPATDVCGTFSSN
IARQIPDRFAHISSKELKEPER-----G---RRNSTRSQASRHEEHVQNIRRFHESLQ-Q
GEALLPCGDKLTTSPLS-SRTSILTSLRKNLSELDQIQQYFSQKLTKPFLPLSPQTYTAT
LQCQESCKDPVVRGA--S-SLDP---ESQCILEKSNNLILQVSSLITDLQSIT--RNS-Q
ATMSSHRTR---SKNSKVTTLADAHDTEVMQEQSTTPD--KPLAGAPDEGTNSSPPPTLE
ETSNR-EGILHKSLGHTVPITGMQS-------------------S---EDTEPGLAYSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDTS-EIISPQPDEVQRKDPSCTSPEPFAK-
EELKIASSFLSVPERAV-----------NPDLHRYSSLSQSLVACEDGASKAKFG-EPT-
SANPQFI-----LGAKQSNAFVGWS-SP--QGNQDKEPTPEAQAEKEA------ASS---
-------------ELSDS-------------SDSF-EKF--PLHLASQSRQEIHKKPTID
------------------------DSDVSQKQVTTGSET-STKQSI---LLPEPIVVPNF
FLPPQQLEASLRMLSVSAALPPPATTDEDKSGATRGTL---------SRRPCRPRPNSL-
-------PPNLPEEESRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LSQLSPTHQINGFFTIVSSTSKKLGELKVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIGGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIVETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-RVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNHIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMTMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVPLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDHYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAENRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFSSEH
HHSLLLPAEIPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HHEDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRQRVLEAAGLLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNRKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPLEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCKDHLGPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTTPD--EPLARAPDKGTDSPPPPPLE
KTSNG-GRMLHESLRHTVLITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSYLPREGSPSQSLVACEGEASKAKVSGESA-
SANPQPTPCPTLSGAQQSSTFVGWS-SP--QADQNKEPKSEAPAENEA------ATG---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREEHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPTVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PTNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------RQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEITF-AI
YHENTKSVSDVASIQSCKEYLL-GVVKVPTKELLVKR-SGKDPELQ-----LSCLLHGLE
LMQKVVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLKDPVKTDEE---E---L
ATVTISTPRLWLPLHCVLLAGHKHIHKNTYCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGSES-MERPHQTDSWIGSAYVDLARL
GEKSTRTLTVSGVYPLFGRNASNLSGAALRVHVVL-SL---SPHTEPTHE-LDSVDCSSH
SESEQIHRGN-HEMQLSPPC---GHQKSPASTQVPCTSTTAEVCLA-Q--ESPAVSDD-T
FAVSILV

PF00168 // ENSGT00510000048072_0_Domain_3 (1868, 1974)

ERAMHLSLKGIPLTERKVPVPSCCVSFATA-VESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSK
ITWETFVIQAR-------TDKARTVVVGIALECH------FR---ISFHIGG--------
-------------EFILLPFSF-----N---RNNTIRSPASRHEEHVQNIRRFHESLQ-Q
SDTVSKSENRLNTLPLS-SSPSILTSLRCGLVLRKDIGSYMRRTALP-QLPLLR------
--RFSRRRSCMSDSV--S-AKSPRLGESMSVMRKAQNLESQILNMLSSS-----------
SANHLNSLN---LKSQKVTTLPDAQDTEAVQERSTTPD--EPSARAAEAATNSPPPLALQ
ETSNG-EGMFQESLGHTVLVSRMQS-------------------S---EETEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPDKVHRESLSSPSPEPAPR-
GALRARGSFPSSPKMAV-----------SSHLPGQSSQT--YKSND--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFYPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPIDEDSLR
AS-T------------Q-IRA-LSRNQFKDHIEDHLLPSTE-NAFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPENAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPLQQENG---QSPFGPLKVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMT-----------KNLQILNQIHEETAKKAQNLVLP-RKSPSPVAPHPS-TFVATP
ASHNLVNQTNRTTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLF--------
------------------VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDCYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYIQYYFPVQHSQSSALKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYP-VRDQK------------
-VAKGTLPL-SRICAMVTTQ---HREDLGMHTFNLPLT----------------LLDVGL
RYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYPIILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEGFWTPLKKPKESLNKKQIM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEVISCHQKSPASTQVPCSSTTAEVFLT-H--EGPAELDG-T
FAVSILVERAMHLSLKGSPLTER

PF00168 // ENSGT00510000048072_0_Domain_3 (1884, 1952)

KVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MTRQTLDQLAHASSKELDFSSP-----GR---SGTTRSQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITGSY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----LSDISPSTSLPPLVEGQLRCFLKLTVNKVVWKIAKPP-SCVLVRVRWWGETSDGT
LFCPRDTLQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQISG
LAKLSPTHHISGFFSIISPTSKKLGELQVSLALEPLSETYDSYNPLPTTDMTENVLLPEQ
GFREYTEPSNTQFLVPSR---SCRIPTTKIDGKDLATNSS-RSTTP---RGKDHLYFAEN
SDTTKDSVFRLQHHLNSGQSLE-----SMTLKDKAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMAVSAMKSSPDTSMLLLDEVHPPMKEDFLK
TST-------------Q-IKV-LSKNQLKDPIEDHL-PPNE-NTFWKHDTKADTRAIQLL
LGSAELSQGNYWDGLGSPPDSPSPGSDVYCSSEPNDPQYDQSLLENLFYTA-PKSDTSIS
DFFTEDDDIVPPKKMSQSKALARSSKVLESNDHKLKKR--------AAGKKNRNL-----
VEQQMVSKTPEDAQVMTLSVDRLA-LGRTHSVRIIIETMGVPPDSPQI-TPGKKSFPRRP
PKVTT--------TKKRTFFVEYHFPVGFSKSGLEKTALITEVVRLASSKIIDG-VVKFQ
QRFVFPVQFGGPMIEHWWKSNLIFQIYTKKTSQIKPEVIGSASLPLRAVIQSELLSFSDQ
LPVQQENG---QTPLGPLKVTMELVIDNKDFTGVKTKLN-SSTQHTPLCAVKSPDKKLPE
PSQRVTC---------TKNPQNLNQVHEETAKEAQNLVFPNPKSPSPVALYSS-AFMAVP
ASHNLVNRTDGSTKESALLLHVLLMVPDGKDFITGESEKQLPCNVYFNCKLFSTEEVTRS
VIAWGTTKPVFNFSH---VIPVSLSPKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGQQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSPRPPHFLDPPS-VASIAMAEDQRNGLMEHHFELHIDKVKGLTPL-
--QATVWGEADCYVQYYFPVQDSQSSMLKGPEFLENGITLKPFRSATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQALVPGGGVHFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMR---RCD--VIQTFNLPLTPRRENRTEVRN-QQSXXXXXXX
XXXXXXXXXXXXXAARAVSISVQ-IRACGLQAAAXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXX-XXITGWYPIILPEDGAVPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NNLKDIVKMGEE---EPAEP
ATVTISTPRLWLPIHCVLLADQKHIHKNTYCYLRYKLYDHEGFWTPLKKPKESTNKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERTARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPHLEPTHE-LDSMDCSSH
SESEQHPRRN-DEIQLSLPP---GHQKSPASTQVPCNSTTAEVSLA-Q--EGPTELDG-T
FA

PF00168 // ENSGT00510000048072_0_Domain_3 (1863, 1956)

VSILVERAMHLSLKGSPLTERKVSIPSCCVSFTTA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQARRVVETQGS-LIPKYSP---FSFPISDMYAAFPSC
IARQTPEQLAHTSSKELDFSSP-----G---RSSTARNQASRHEEHVQNIRRFHESLQ-Q
GEAILPSRDKLTTSPLS-SHPSILTSLRRNLSELDQIQRYFSQKLIKPVLPLSPQTQ-TI
LECQENHRDCHGPG--AS-SLDP---ESQCILEKSNNLVLQVSSLITGNY----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLIRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENAEPSSTQFQVPSRP---RDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRVP-RKQMSLLNSSEFQPQIRTLAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNLWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSGTSIS
DLLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKR--------SADKRNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
HKMTT--------AKKRTFFVEYHFPVGFSESRLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKLMYMHSVN-----------------
--------------ILTIRVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETANKAQNLVLPNRNSPSPVAPHPS-TFIATP
ASHNLVNQTNGSTKESALLLHVLLMVPDGKDFISGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQK------------
-VAKGTLPL-SRICAMVTTQ---HCEGVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRIAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQREQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVVF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSMKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHRNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIM
VPFKASKRAEITRGPSVLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDYSSH
SESEQLPRRN-GEVQLSPPEVVSCHQKSPASTQVPCSRTTAEVCLT-Q--EGPAESDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEEKQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQVALASSKELDFSSP-----GS----GTTRSQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQKYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLGPGA--S-SLDP---GSQCILEKSSNLFF------SNLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQDTEALQERCTMPD--EPLARAPDKGTDSPPTHPLI
ETSNG-GRMLHESVRHTVPITRMQG-------------------S---EDTEGGPAYSDE
DYEEDIIEPRTLNEIITVTDKTSPWSSFISDKS-EVISPQPDEVQREGPSCPSPGPFCR-
EELTVKSSFLSSPERAV-----------NPHLPRQGSPSQSLVACECEGSKARVG-ESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRRKNHKGPPID
------------------------SSDIRQRQVTTGSET-STKQSL---LLPGPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PSNLPEEETRR---IARI--FSSRYFQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MRQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTPKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIVETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKIANG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYTKKTPQKKLMYMHSVN-----------------
--------------ILTIRVTMELVTDNKDFTGINTKLS-GNTHYTPLCAPTSLNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISHLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEIPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQV------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRCSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQRCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRQRVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPLEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRFVLSVCSSAFQNLLFVARH---KVRRVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCKDHLGPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDAQDTEALQERCTTPH--EPLARAPDKGTDSPPPPPLE
ETSNR-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDAS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVGCEGEASKAKVSGESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATSPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKRRKAPGPGGDGSRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKITKPP-ACVLVRVRWWGETSEGT
LFCPRDTLQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLEHLPVGRVQISG
LAQLSPTHHINGFFTIVSPTSKKLGELQVSLALEPLSETFDSYTPLPTTDMTENVLLSEQ
GFREYTEAGNTQFLVPSR---PQRIPTTKIDGKELAANSS-RSTTP---RGKXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXLLEQGNKLRNAMVISAMKSSPDTSML-LEEVHPSMNEDFLR
AST-------------Q-IKA-LSRNQFKDHIEDHLVPPTE-NTFWKHDTKADTRAIQLL
LGSAELSQGRYWDGLGSPPDSPSPGSDVYCSSEPSDPQYDQSLLENLFYTA-PKSDTSVS
DVFSGNDDVVLSKKLSQSKALARSFKVLESNGSLIXXXXXX----XXXXXXXXNL-----
IEQQMLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSLQE-TPGKKSFPGRL
PKLT---------TKKRTFFVEYHFPMGFSKNGLTKTALITEVVRLASSKITDG-MVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYTKKTPQLKPEVIGSASLPLRAVIQSELLSFSDQ
LAVQQENG---QTPLGPLKVTVELVIDNKDFADVNTKLS-SNTQHSPLCALTSPDKTLPE
PSQHVTC---------TKNPQNLNQIHEETVKKTQNLVLPIPKSPSPVAPSPS-TFTAVP
ASHDLINQINVSTKESALLLHVLLMVPDGKDFITGESEKQPSCNVYLNCKLFSTEEVTRS
VITWGTTKPVFNFSQ---VIPVSLSSKCLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDSYMPVIDMFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-PPFNPRPAHLLDQPS-AASVAMAGDQGNGLMEHHFELLIDKIKGLAPL-
--QATVWGEADCYVQYYFPVQDSQPSVLKGPGFLENGFTLKPFRSATTLCIPDPIFNSEH
RHSLLLPAEIPVQRLLLSAFSAHGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAIVTMQ---HREDVGIQTFNLPLTPRLENRNELRN-QSSGLLDVGL
RYRCTPRTAEGVLAARAVCISVQIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRQTHPVACSFCPEFSHHSE--FSCNLVTQHCSGEACFLAELLEFAEVTF-AI
YHEDTKSASDITNIRSFKDYLL-GVVKIPTKDLLIKRSXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX--X--XXXXXX----XXXXXXXXXXXX---XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXNTYCYLRYKLYDHEGFWTPLKKPKESANKKQVM
VTFKASKRAEVSRSPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHPGPTNE-LDSMDCSSA
SESEQLPRGN-DELQLSPPH---DHQKSPASTQVPCSSTTAEVCLA-Q--EDPTALDG-T
FA

PF00168 // ENSGT00510000048072_0_Domain_3 (1863, 1956)

VSILVERAMHLSLKGSPLTQRKVSIPSCCVSFTTA-DEPSPIYTPVVENTDSPIWNFQ
QQSRLSKELLLDPRQTLVFKVWHKG-GEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAISPLESLMHFREERQARRGMETSGS-LIPIYST---FSFPASDMYGAFPGC
IAGQTPEQLVHTSSKEVDFSSP-----G---RSSTTRSKASRHEEHVQNIRRFHESLQ-Q
GEAILPSDDKLTTSPFS-SHTSILTSLRRNLSELDQIQQYFSQKLTKPLLPLSPQTHTAT
SQCQESQGDHLRPG--AS-SLDP---ESHCILEKSNNLVLQVSSLITGNYC---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKTDGKELGANSS-RSTTPRKNRGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRAVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKNISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKDFTGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNLQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVSISVQIIRACGLQAAANSLTTTPLFLVYMCHVGLLQPLTRHL
HFLHMASQFSQHHLLCSFCLGLSWQLTLTRLCNLVCRILSHISQFFHELISFNEILHLRI
YHLSLYSAYSKVSTLFCFSLPIPSIIESQSLLISQRK-KGITGWYPIILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSILVERAMHLSLKGSPLTER

PF00168 // ENSGT00510000048072_0_Domain_3 (1884, 1952)

KVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----GS--RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPHTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNSKATTLPDARDTEALQEQCTTPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVACEGEASKAKISGKSA-
SANPQPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PANLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRRGQGPGGGHGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPLGRVQIGG
LAQLSPTHQINGLFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTTDMMENVLLSEQ
GFRENTEPSNTQFLVPSRP---HRMSTIKIDGKELVGNNS-RSSTP---RGKDHMYFAEN
PDIIKDSFLELQHHLKSGQSLE-----SVTLKGKAP-RKQMSLLNSSELQPQIRTVSKSH
SDSCILSSNKPPTNDLLSALLERGNKLRNAMVISAMKSSPDTSML-MDKVHSPIKEDSHR
PS-A------------Q-IRS-LFRDQFKDHIEDHLLPPTE-NTFWKSDTKADTRAIQLL
LGSAEFSHSHFWDGLGSPPDSPPPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSETSMS
DFLSEDDDIAHSKKMNKSKTLARS-KVLESRDHKLKKK--------AAGKKNRSL-----
VEQQMLSETPEDTQVMTLSVDRLALLGRTHSVRIVIETMGVPPDSPQM-TPGKKSFAGRP
PKLTT--------AKKRTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKITDG-VVKFQ
QRSMFPVQFGGPMIEHWWNSNLTFQIYAKKMPQKKPEVIGCASLPLRAVIQSELLSFSDQ
LPVQQKNG---RTLLGPLKVTLELVTDNKVFTGVNTKLS-SGIQHTPACAPISPDKILPE
PSQDITC---------TKNTQNLNQINEETAEKPLNLVLSNSKSPS---ANPS-TFKTMP
ASHNLVNQTNESTKESTLLFYVLLMVPDGKDFINGESEKQPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNIYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAQYPVVAVDSYLPVIDVFSGHQNGNLRVFLAMGSSDQIMAV
QRLKNEEGTL-PPFSPRPAHLLDQPS-VAAVAMAEDQGNGSMEHHFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEIVENGITMKPFRTGTTLCVPDPIFNSEH
HHSLLLPKEVPVQRLLLSAFSAQGLMPRSGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDMGIQTFSLPLTPRIENRKELRN-QSSGLLDVGL
SYRCSLRTAEGVLSARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKVLAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTRTVACSFCPEFSHYLE--FSCNLVTQHCSGEACFLAELLEFAEITF-AI
YHKNTKSASDITSIQSCKDYLL-GVVKVPTRELLAKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1868)

IILPEDGGLSQGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NSLKYLVKVDEE---K---P
ATVTISTPRLWLPIHCVLLAGHSHIHKNTYCYLRYKLYDHEAFWTSLRKPQESANKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPPPEHTHE-LDSMDCSSH
SESEQLPRRN-DEIQLSPPC---GHKKSPASTQLPCNGSTAEVCPA-Q--EGPAELDG-T
FAVSILV

PF00168 // ENSGT00510000048072_0_Domain_3 (1868, 1974)

ERAMHLSLKGSPLMEQKVSIPSCCVSFVTA-DEPSPIYTQVVENTNSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLMHFREERQARRGVETPRS-LLPIYSP---FSFPAADMHVTFSSN
IAKQTPNQLAHISSKELDMSSP-----G---RSSITRSQASRHEEHVQNIRRFHESLQ-Q
GEAILPCDDKVTTSPLS-SHTSILTSLRKNLSELDQIQRYFNQKLTKPFLPLSPQTHTAI
LQCQESCRDPVGPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RNS-Q
AALSPHRTR---SRSSKVTTLPDAQDTEIMQEQSTTPN--KPLARAPDESTNSPPPPALE
ETSNG-EGMLHESLGHTVCITRMQS-------------------S---EDIETGLACSDE
DYEEDIIEPRTLNEITTVTDRTSPWSSFMSDTS-EVISPQPDELQRKDPFCTSPEPFPK-
EELKVRSTFLSIPKRAI-----------NPHLPRQGSPSQSLVACEGGTSKARVG-EPT-
SGDPQLIPPLTLSGAQQSKAFVEWS-SS--RGDQNKEPKREAQAEDEA------ASS---
-------------ELSDS-------------ADSF-EKF--PLHLVSQSRREIHKGPPIG
------------------------DSDISQKQVTTGSET-SKRQS----LLPEPIVVPNF
FLPPQQLEASLRMLSLSAALPPQATTDQDKSEATKGAL---------SRRPCRPRPNSL-
-------PPTLPEEETRR---IARI--FSARYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPVGVRGRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKSVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKIDHLPIGRVQISG
LAQLSPTHHISGFFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPSTNVKENVLLSEQ
EFREYTEPSSSQFLVPSR---PHRMPTTKIDGQELAANSS-RSTTP---RGKDHLYFTEN
SDTIKDSFFGLQHHLNSGRSLE-----SMTLKGKAP-RKQMSLLNSSEFQPQIRTVARSH
SDSCILSSNNPPTKDLLSALLEQGDKLRNAMVISTMKSSPDTSML-LDEVHPPMKEDFLK
AST-------------Q-IKA-LSRDQFKDHITDHLLPPTE-NTFWKHDTKDDTRAIQLL
LGSAELSQGRYWNGLGSPPDSLSPGSDVDCSSELNDPQYDQSLLESLFYTA-PKSDTSIS
DFFSED-DIVASKKMNQSKALAKSPKLVESSDPKLKKR--------AAGKKNRNL-----
VEQQMISETPEDAQVMTLSVDRLALLGRTHSVRIIIETMIVPPDSPQM-TPGKKSFSGRP
LKLTA--------IKKRTFFVEYHFPVGFSKNGLGKTALITEVVRLASSKITDG-MVNFQ
QRFVFPVHFGGPMIEHWWNSNLTFQIYTKKTPQKKPEVIGSASLPLRTVIQSELLSFSNQ
LPVQQENG---QTPLGPLKVTIELVIDNKDFTGVNTKLS-SSTQHNPPCALTSPNKTLSE
PGQYVTC---------TKNPENLNQIHKEAAKKVQNLVLPKPKSPSPVISNPS-TFMNVP
ASHNLANQTNGSTKETSLLLHVLLMVPDGKDFITGESDKQPPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFLQ---VIPVSLSSKYLERLKNNVMVIEAWNKLRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPS-TASVNM-EDQRSGLMEHHFELHVEKVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGSEFPENGISLKPFRSATTLCVPDPIFNSEH
HHSLLLPSEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQV------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1474)

SVQVIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRRTRPIACSFCPEFSHHIE--FPCN

ENSGT00510000048072_0_Linker_2_3 (1474, 1888)

LVTQHCSGEACFLAELLEFAEVTF-AV
YHEDTKSASDITSIQSFRDYLL-GVVKIPTKELLVKR-SGITGWYPIILPEDGALPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWNFE----NNLKNLVKMNED---E---P
ASVTISTPRLWLPIHCVLLAGQSHIHKNTYCYLRYKLYDHEAFWTPLKKPKESTNKKQVM
VTFKASRRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-LERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLAGAALRVHVVLSSP---SPHPGPAPE-LDSVDCSSH
SESEQFPRRN-DEIPLSPSP---AHQKSPASTHVPCNT-TKEVSPA-E--ESPATLDG-T
FAVSILVERAMHLSLKGSPLTERKVLI

PF00168 // ENSGT00510000048072_0_Domain_3 (1888, 1952)

PSCCVSFATA-DDPSPIYTHVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEEKQSRRGVETPGL-LNPVYRP---FSFPASAFL----SS
IARWTPEQFAHTSSKELDFSSP-----E---RSSTTRSQASRHEEHVQNIRRFHESLQ-Q
GEAVLPRDDKLTTLPLS-SRTSILTSLRRNLNELDQIQQYFSQKLSKPLLPLSPQSY-SI
LQCQESHRDHRGPG--DS-SLDP---ESQSILEKSNNLVLQVSSLITDLQTIT--KNT-Q
ASLSSHRAR---SRSGEVPTLPDGQETVVMEERSTTPE--LPLARAPDGGRSPLTRPTLE
ETSSG-RGILHESLGHTVPITRMQS-------------------SEET---EAGQAYSDE
EYEEDIIEPRTLNDITTVTDKTSPWSSFMSDTS-EV-----NEVHREGPSCSSSKHFPR-
DELKGKSSPLSSPGRVV-----------QPHLLGQGSSSQSLTACEGESSHSRDG-ESA-
SAVPHLVSQVTVSEAQQSNTSVGLS-SP--RANQDQEGRLEAQTENEA------ASS---
-------------ELSDS-------------ADSF-KKF--PLHLASRSRKESHRGLPIN
------------------------CSEIRQNQATSGTEV-STRQSL----LPEPIVVPNF
FLPPQQLEASMRMLSLSAAMPPPAATDQDKSEASSRVL---------SRRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKAQGPVGVRGRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDTLQTEPKAVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQISG
LAQLSPTHHINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTTDVKENVLLSDQ
EFREYTEPSSTQFLVPSR---PHRMPTTKIDGKELAANSS-RSTTP---RGKDHLYFAES
SDMVKDSFFGLQHHLNSGQSLE-----SMTPKGKAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISTMKSSPDTSML-LDEAHSSMKEDFLK
AST-------------Q-IKA-LSRNQFKDHIEDHLLPPTE-NTFWKHDTKDDTRAIQLL
LGSAELSQGQYWNGLGSPPDSPSPRSDVYCSSELNDPQYDQSLLESLFYTA-PKSDTSIS
DFFSED-DTVPSKKMNQLKALAKSPKLLESNDLKLKKR--------AASKKNRDL-----
VEQQMISETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TSGKKTFSGRP
PKLIA--------TKKRTFFVEYHFPVGFSRGGLGKTALITEVVRLASSKITDG-VVNFQ
QRFVFPVHFGGPMIEHWWNSNLTFQIYTKKTPQKKPEVVGSASLPLRTVIQSELLSFSNQ
LPVQQENG---QAPLGPLKVTVELVIDNKDFTGVNTKLS-SSTQHSPPCALTSPDKTLSE
PGQYVTC---------NKNPENLNQIHKEAAKKVQNLVLPSPKSPSPVAPNPS-DFMAVP
ASHNLANQANESTKETALLLHVLLMVPDGKDFITGESDKQPPCNIYLNCKLFSTEEVTRS
VTAWGTTQPVFNFFQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFHPRPAHFLDQPS-IASVNMAEDQRNGLMEHHFELRVEKVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEFPENGISLKPFRSSTTLCVPDPIFNSEH
CHSLLLPTEVPVQRLLLSAFSAQGLVPGGGIQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARAVSISVQIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHVE--FPCNLVTQHCSGEACFLAELLEFAEVTF-AI
YHEDTKSASDITSIQSCREYLL-GVVKVPTKELLVKR-SGITGWYPIILPEDGALPHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NNLKNLVKMNEA---E---P
AIVTISTPRLWLPIHCVLLAGQSHIHKNTYCYLRYKLYDHEAFWTPLKKPKESTNKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNHS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHMVLSSP---SPHPGPTPE-LDSVDCSSH
SESELFSRRN-DEIQLSPSP---GPQKSPASTHVPCNNTTREVCPA-E--EGPAKLDG-T
FA

PF00168 // ENSGT00510000048072_0_Domain_3 (1863, 1956)

VSILVERAMHLSLKGSPLTQRKVLIPSCCVSFATA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQSRRGVETPGS-LIPIYSP---FSFPASDMYAALPSC
VARWTPEQLAHTSSKELDFSSP-----G---RGGPTRSQASRHEEHVQNIRRFHESLQ-Q
GEAVLPRDDKLTTLPLS-SRTSILTSLRRNLNELDQIQQYFSQKLTKPLLPLSPQTH-TI
LQRQESHRDHHGPG--DS-SLDP---ESQCILEKSNNLVLQVSSLITDLQTIT--KNS-Q
ASLISHRAR---SRSGEVPTPPDTQDTVAIPERSTTPD--LPLTRAPEEGRNPLIPPTLE
ETSIG-RGILHESLGHTVPITRMQS-------------------SEET---EAGPAYSDE
DYEEDIIEPRTLNDITTVTDKTSPWSSFTSDTS-EVINLQPDEVRREGCSCPSSKPFPR-
EELKGKSSPLSSPRRAV-----------PRHLLRQGSPSQSLTACEAEASHARDG-EPA-
SAGPQLVSQVTLSGAQQSSTSVALD-SP--RAGQDQEPKPEAQTESEA------ASS---
-------------ELCDS-------------ADSV-EKF--PLYPASQSKKESHRGLPIN
------------------------CPDIRQKQATPGSEV-STRQSL---LYPLPIVVPNF
FLPPQQLEASLRMLSLSAALPPPATTDQDKSEASSRAL---------SRRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQEPGGGRGRKKR-
----GLSDILPSTSLPPLVEGQLRCFLKLTINKIIWKITKPP-TCVLVRVRWWGETSNGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKVDHLPIGRVQING
IAQLSPTHQINGFFTIVSLTSKKLGELQVSLALEPLSETYDSYSPLHHTDKTQNGHLSEQ
EYRKNTEPSSTQFLIPSRS---HGIPTVKIDRKELAANSS-RSSTP---RGKDHLYFAEN
SDTIKDSFFGLQHHLNSGQSLE-----CIAVEAKVP-QKQISLPDSTQYQPQIRIAVKSH
SDSCVLSSNNRPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDKVHPPVKEDSLT
S---------------------SAQNQLKGHIEDQVLSPTE-HTFRKHDTKTETRAIQLL
LGSAELSKDHCWNGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDNSIS
DFLSEDDDIFPAKKMNQSKALGRSSKVLEPKDHKLMKR--------TASKENKDL-----
AEPQLLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPVDGLEM-TPGKKSSAGKP
PKLTT--------VKKRTFFVEYHFPVGFSKSGLEKTALITEVVRLASSKVTDG-MVKFQ
QRSVFPVQFDGSMIQHWWNSNLTFQIYAKQPPQKKPEVIGSALLPLRAVIQSELLSFTGQ
LPVQQENG---QTPLGPLKVTVELVRDSKDFTGVNTKLT-SSTQHTPLCAVTSPEKILQE
SKQDTNC---------TRNPQNLNQIHEETTKKAQNLVLPNPKSPSSVATNSS-AFVAVP
ASHSLLNQANESTKENALLLHVLLMVPDGKDFITGESEKQPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNVYLICKFFSTEEVTRS
VIAWSTTQPVFNFSQ---VIPISMSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKVSRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKTEEGTL-PPSGPRPAHFLDQPS-VASVAMAEDQGSGLMEHHFEFRVEMVKGLVPL-
--QATVWGEADCYVQYYFPFQDSQSSVLRGPEFLENGITLKPFRTATTLCIPDPIFNSEH
HHTLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEVWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTVQ---HREDVGIQTFNLPLTPRFENSKELRS-QSSGLLDVGI
RYRRSPRTAEGALAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALQFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEITF-AV
YHENTKSVSDIASIQSCKEYLL-GVVKIPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VLLPENTGLPHGLE
LMQKVVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLKDLVKTDEE---E---L
AMVTISTPRLWLPIHCVLLAGHKHIHKSTYCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGSDS-MERPHQTDSWIGSAYVDLARL
GEKSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPHAEPTHE-GDSMDCSSH
SESEQPPRGN-EEMELSPRC---GHQKS-ASTQVPCNSTAAEVCLA-Q--EDPPELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTKRKVPVPSCCVSFATA-VEPSPVYTQVVENTESPIWNFQ
QQSRLSKELLLDPQQTLVFKIWHKG-GEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLIRFKEERQARRGMETQAS-LTPVYSP---FSFPASDIRAAFPGG
VARHTQDQLTYTSSKDLHCSSP-----G---RSNTVRSPGSRHEEHVQNIRRFHESLQ-Q
GEAVSASDDGLTASPLS-SSTSILTSLRKNLSELDEIQQYFSQKLTKPFLPLSPHTNPAI
LQCQENHRDQPGPGV--S-SRDL---QNQCILEKSSNLVLQVSSLISDLQTIT--KNS-Q
AALTSHRAR---SRRQEVTTLADAQDTEAVQERSTTPD--EPLASAAEAGTRSPPPPALE
GTSDG-GGVLQEPLGRTVPVSRMQS-------------------S---EEAEAGPAYSDE
DYEEDIIEPRTLNEITTATDKTSPWSSFTSDTS-EAISPQPDEVQKERPSSPSPGPSPR-
EALRAKGSFLSSPKMAV-----------DSHLPRKSAPS--LVACEGGASKARVG-EAA-
STTPQPGTYLPHSGTQRSKTFIGWS-SP--RADQDKEPKPEAQADNEA------ASS---
-------------ELSDS-------------PDSM-EKS--PQHLTSQRKRESHKKPPVE
------------------------SPNIRQKQVTTGSEV-STRQS----LLPEPIVVPNF
FLPPQQLEASLRLLSFSTALPPPAAADEDKSEATSGAF---------SQRPCRPRPHSL-
-------PPNLPEEETRR---IARI--FSSQCSKKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRRGPGPGGGRGRRKR-
----GLSDIPPSTSLPPLVEGQLRCFLRLTVNKVIWKVAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTGRFLFHHFN-S------------PV
HAQPSPQHLLINRG---ERICYIALLCQVSLALEPLSETYDSYNPLPTTDMTENVLLSER
RPRENAESSNTQFLVPSRS---YGMPIIKSDGKELAANSS-RSTTP---RGKDHLYFTEN
SDTGKESFCGLQPYLNSGQSLE-----TGALKGKAP-QKQMSLFNNAEFQPQISTVAKSH
GDSRVLSSSNPPTKDLLSALLEQGNKLRNAMVISAMQSDPDTSIL-LGKVHPPAKEDSFR
SS-A------------Q-VKT-SPKNQFKDHSDDHLLPVTE-N-------SSDTRAIQLL
LGSAEFSQGHVWNGLGSPPDSPSPGSDVYCSSDPNDAQYDQSLLENLFYTA-PKSDVSLS
DFLSDDDGMEPSKKMNQSKTFDRSSKILESSEHGLKKR--------TTDMKNGDF-----
IDQQLAS---GDTQVMTLSVDKLTLLGRAHSVRIIIETMQVPPDSPQM-TAGKKSFSGRP
SKVTT--------VKKSTFFVMFHFPVGFSKSGLGKTALITEAVRLASSKVTDG-MVKFQ
QRFVFPVQFGGSMIEHWWNSSLIFQIYAKKIPQKKPEVIGSASLPLRTVIQSELLSFSGQ
LPVQQESG---PTPLGPLKVTMELVIGSKDFTGVGATLG-SNTQHPPLAAATNPDKILPE
PSQDTTC---------TKNPPNPSHIHEETAQKAQNLILPNPKSPSPLAPNSS-IIMAAP
TSHHLMSQINGSTKEDALLLHVLLMVPDGKDFFTGESEKQPPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPACLSSTYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLEAKYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSEQITAL
QRLKNEEGTL-PPFSPRPAHFLDQPS-AASVAMAEDQGNRLMEHHFEFHVVMVKGLTPL-
--QATVWGEADCYVQYYFPFQDSQPSVLKGPDFLENGITLKPFRTSTTLCVPDPIFNSEH
HHSLLLPLDIPVQRLLLSVFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTRQ---QREDMGMENFNLPLTPRLENRNKLKS-QSSGLLDVGL
RYRRSPRTAEGVIAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQVIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEIIF-AI
YHENTKSVNTIASIQSCKDYLL-GVVKVPTKELLLKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1865)

VILPEDESLPQDLE
FMQKIVGGLELSISFTHPGDRERVLEAAELLGWSFE----NRLKDLDKLEEE---V---P
ATVTISTPRLWLPVHCVLLAGHRQIHRSTYCYLRYKLYSHEAVWTPLRKPKESTNKNQVL
VTFKASKRAEVTRNQSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GEKSARTLTVSGVYPLFGRNASDLRGAALRVHVVLSPL---APHAEPTQD-MDSTECSSH
SEPEQLPRKN-DDIQLSPSC---DHQKSPAFAQVPSNSSVAEDCQT-Q--EGPAESCG-T
FAVS

PF00168 // ENSGT00510000048072_0_Domain_3 (1865, 1974)

ILVERAMHLSLKGSPLTERKVSAPSCCVSFATA-DEPSPVYTHVVENTDSPIWNFQ
QQSRLSKELLLDPRQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLVHFKEERQARRGSETPGS-LMPMYSP---FSFPASHTCATFPSH
IARHTQDQLVHTSSKAHL-SSP----------AIGTRSQAARHEEHVQNIRRIHESLH-R
GEAVSTVDEKPAAAPSS-SQTSILTSLSPC---------SFQHTLLPPFLPYRFPN----
-------------------------------------------CHQLDLQTIT--RES-Q
AALTSHQAR---SRSREVMTLADAEDTEAMR-QSAAPE--EPLARAVEESGSSPPPPALE
ETSSG-E-VLPEPLGHTAPIERLPS-------------------T---EDTEAGPADSDD
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVMSPQPSKVQSTH-PCPSPGPCPRE
-------ELKSSPERTV-----------QPHLPGQGSPSQSLTACEGGASKAGVG-EPA-
LTKPQLILHPSLPRAPQSNAFVGWS-SA--QADQDMGSIPEAQAEKET------ASS---
-------------ELSDS-------------SDSF-EKS--PPFLSYQSKRENLKEPPMD
------------------------SPDVRPKQMASGSEV-STRQN----LLPDPIVVPNF
FLPSQQLEASLRMLSHCAALPPPATADQEKSEATRKAP---------SQRPCRPRPNFL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTEDVLLSKQ
GFRENTEPSSTSFLVPSRP---HDIHTIKIDGKEIAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSFFGPQHHLNSGQSLE-----SVTLKGKAP-RKQMSLLNSSEFQPQIRTVAKSR
SDSCISSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPMKEDSLR
AS-T------------Q-IRT-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKTDTRVIQLL
LGSAELSQGNIWDGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSENMNQSKALARSSKLLESGDHTLKKK--------SAGKRNRNL-----
VEQQMLSETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-APGKKSYAGPL
PKLTT--------AKKRTFFVEYHFPVGFSESRLGKTALITEVVRLASSKITDG-KVKFQ
QRFMFPVQFGGPMIDHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQENG---QTPFGPLKVTMELVTDNKDFTGVNTKLS-DDTHYTPLCAPASPNKALPE
LNRDKTC---------TKNLQNLNQIHEETAKKAQNLVLPDRKSPSPIARYPS-TFMAMP
ASHNLVSQTNESTIESALLLHVLLMVPDGKDFIIGESEKQPPCNVYLNCKLFRTEEATRS
VIAWGTTQPVFNFSQ---VIPVSLSSTYLERLKNNVMVIETWNKVWSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGTL-PPFSRRPAHFLDQPT-VASVAMVEDRGNGLMEHCFEICVKMLQGLTTF-
--QATVWGEADCYVQYHFPVQHSQSSVLKGPEFPENGITLKPFRTATTLCVPDPIFNSDH
HHSLLLPAEVPVQRLLLSAFSAQGVVPGGGVQFEIWYRYYFPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDMGIQTFNLPLTSMIEDRKELRN-QSSGFLDVVL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKVLAEQE-ALQFSATVGVNASVTTHL
SFLPQEKQRRTRPVACSFCPEFSHHIE--FTCNLVTQHSNGEACFLAELLEFAEVVF-AI
YHENTKSAGDIISIQSCKEYLL-GVVKIPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHPGERERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATITVSTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIV
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSAKTLTVSGVYPLFGQNASNLSGAALRVHVVLSSL---SSHREPTHE-LDSMDCSSH
SESEQLPRRN-DEVQFSPPEEVSCHQKSPTSTQVPCGSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEEKQARRGVETSGS-LIPVYSP---FSFPASDMYAALSSH
MARQTLDQLNHISSKELDFSSP-----G---RSGTTRSQASRHEEHVQNIRRFHESLH-Q
GETLLPCDDKLTTSPLP-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTHTAI
SQHQESCRDHPGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQYTEALQERCTTPD--EPLARAPDKGTDSPPPPALK
ETSYG-GRILHESLSHTVPITKMQI-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-EVISPQPDEVQREGPSCPSPGPFCR-
EELTVKNSFLSSPERAV-----------KSHLPRQGSPSQSLIACEDEASKAKVGGESA-
SANPRPLPCLTLSGAQQSSTFVGWS-SP--QVDQNKEPESEAPAENEP------ATR---
-------------ELSDS-------------ADSF-KKL--PVNLASQSRRENHKGPPIN
------------------------SSNIRQRQMTTGSEM-STKRSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATTGAL---------SHRPYRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQIKGQEPGGGRGRKKR-
----GLSDILPSTSLPPLVEGQLRCFLKLTINKVIWKITKPP-TCVLVRVRWWGETSNGT
LFCPKDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
IAQLSPTHQISGFFTIVSPTSKKLGELQVSLALEPLSETYDSHSPLPHTDKKQSVHLSEQ
GYRKNTESSNTQFLIPSRS---HEIPTIKTDGNELAANSS-RPSTP---RGKDHLYFSEN
SDTIKDSFFELPHHFNSRQSSE-----SVRLKTKAP-QKQIFLLNSTEYLPHIRTAAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDKVHPVK-EDSLT
-SST------------Q-IRALSTRNQLKDHIEDHVLSPTE-HTFGNHDAKTDTRAIQLL
LGSAELSKDHCWNGLGSPPDSPPAGSDVYCSSELNDPQYDQTLLENLFYTA-HKSDNSIS
DFLSEDDDIDPAKKMNQSKALGRSSKVLEPNDQKLMKR--------AANKKNKNL-----
AEQQLLSEALEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPIDSPEM-TPGKKISAGKP
PKP-T--------VKKCTFFIKYHFPVGFSKSGLGKTALITEVVRLASSKITDG-MVKFQ
QRSVFPVHFSGSMIQHWWNSNLTFQIYAKKTPQKKPEVIGSALLPLRAVIQSELLSFTDQ
LPVQQENG---HTPLGPLKVTIELVRDNKDFTGVNTHLT-SSTQHTPLCVATSSQKILQE
SNQDTTC---------TKNPQNLNQIHEENTKKAQNLMLPNPKSPSSVAKNSS-DFM--P
ASHNLVDYTNESIKENALLLHVLLMVPEGKDFITEESEKQ

PF00168 // ENSGT00510000048072_0_Domain_1 (1001, 1083)

PACNVYLICKFFNTEEVTRS
VIAWSTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKF--PGQDKLLGLVKLP
LH

ENSGT00510000048072_0_Linker_1_2 (1083, 1400)

QFYVSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-PPSGPRPAHFLDQPS-VASVAMAEDQGSGLIEHHFEFRVEMVKGLVPL-
--QATVWGEADCYVQYYFPFQDSQSSVLRGPEFLENGITLKPFRTATTLCIPDPIFNSEH
HHTLLLPTEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLIPRFENRKELKS-QSSGLLDVGI
RYRRSLRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISIHIIRACGLQAAAKALAEQEPTLRFSATVGVNASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEFAEITF-AI
YHENTKSVSDISSIQSCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VLLPEDTGLPHGLE
LIQKVVGGLELSVSFTRPGDRERVLEAAELLGWSLE----NNLKDPVKIDEE---E---L
ASVTISTPRLWLPIHCVLLAGHKYIHKNTFCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGTDN-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SPHTEPTHE-LDSMDCSSH
SESEQFPRGN-DEMQLSPPC---GHQKSSASTQVPCNSTTAEVCLA-Q--EGPAGLDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVPIPSCCVSFATA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLIHFKEERQARRGMETQAL-LIPTYSP---FSFPTSDIYAGFPSC
IARHTRDQLTHTSSKDLDFSSP-----G---RSSTTRSPASRHEEHVQNIRRFHESLQ-Q
GEAVSASDSKLTTSPLS-SNTSILTSLRKNLSELDEIQLYFSQKLTKPLLPLSPHSNTAV
IQRPENHRDQPGPGV--S-SLDP---QSQCILEKSSNLVLQVSSLISDLQTIT--RNS-Q
AALTSHQAR---SRSQEVTTLPDAQDTEATQERNTTPH--EPLARAAEEGTNSPPPPASA
ETSNG-------FLGHTVPVRRMQS-------------------S---EETEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPDEQ-REDPSSVSPGPSPR-
KELRARSSFLSSPKMAV-----------NTLLPRQGAPS--LVAYEGGASKVTIG-QPA-
STSPWPSTHLPHSGIQRGNTFIGWS-SP--QADQDKEPMPEAQADNEA------ASS---
-------------ELSDS-------------ADSN-EKF--SQHLGSQGKRENHKKPPTE
------------------------APNNRQKPVTAGSEG-SSRQS----LLPEPIVVPNF
FLPPQQLEASLRMLSLSTALPPPATEDQDQSEATRGAF---------SQRPCRPRPHSL-
-------PPALPEEETRR---IARI--FSSQYSKTH------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDVTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHSLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQNLLENLFYTA-PKSDTSIS
DFLSEEDDIIPSKKISQSTALARSSKVLESSDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASNKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQENG---QSPFGPLKVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPS-TFVATP
ASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQK------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLLLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAEHLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYGHEAFWTPLKKPKESVNKKQIM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDCMDCSSH
SESEQLPRRN-DEVQLSPPEVISCHQKSPASTQVPCSSTTAEVCLT-Q--EGPADLDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMCAAFSSH
MARQTLDQLAHASSKELDFSSP-----GR---SDTTRSQASRHEEHVQNIRRFHESLHLQ
GEAPLPCDDKPTTSPLS-SQTSILTSL---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSAGVRGRKK--
---RGLSDISPSTSLPPLVEGQLRCFLKLTVDKVIWKIAKPP-SCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAVRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQISG
LDQLSPTHHISGFFTIVSPTSKKLGELQVSLALEPLSETYNSYNPLPTPDVTENVHLSEQ
EFREYTEPSSTQFLVPSR---PHKMPTTKIDGKELEANNS-SSTTL---RGKDHLYFAEN
SDTIKDSFFGLQHHPNSGQSLE-----SMTLKGKAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDEVHPPMKEDFLR
ASTHRSESTFPH---HR-IKT-LSRNPFKDQIEDHLLPPTE-NTFWKRDTKDDARAIQLL
LGSAELSQDRYWNGLGSPPDSPSPGSDVYYSSDFNDPQYDQSLLESLFYTA-PKSDISIS
DFFSED-DTVPSNKMNQSKVLAKSPKVLESDDLKLKKR--------AAGKKNRNL-----
VEQQMISETPEDAQVMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TSDKKSFSGRP
PKLTA--------TKRRTFFVEYHFPVGFSKGGLGKTTLITEVIRLASSKITDG-MVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEAVGSASLSLRTVIQSELLSFSDQ
LPVQQEHG---QTPLGPLKVTIELVIDNKDFTGVNTKLN-SSTQHSQLCALTSLDKTLSE
PGQYVTC---------TKNPENIDQIHEEAAKKVQNLVLPNPKSPNPVAPNPSMTFVAVP
ASQNSANQTNESTKESALLLHVLLMVPDGKDFITGESDKQPPCNIYLNCKLFSTEEVTRS
VIAWGTTQPVFNFFQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDSYMPVVDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKNEEGKL-PPFSPRPAHFLDHPS-VASVTMAEDQRNGLMEHHFELRVEKIKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEFPENGVSLKPFRSATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VARGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1472)

SVQIIRACGLQAAAKALAEQEPALQFSATVGVNSFVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHVE--FP

ENSGT00510000048072_0_Linker_2_3 (1472, 1888)

CNLVTQHCSGEACFLAELLEFAEVTF-AI
YHEDTKSASDITSIRSFRDYLL-GVVKVPTKELLVKR-SGITGWYPIILPEDGALPHGLE
LMQKIVGGLELSVTFTHPGDRERVLEAAELLGWNFE----NNLKNLVTMNEE---E---P
ATVTISTPRLWLPIHCVLLAGQNHIHKNTYCYLRYKLYDQEAFWTPLKKPKESTNKKQVM
VTFKASKRAEVIRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GETSARTLTVSGVYPLFGRNASNLSGAALRVHVILSSP---SPHPGPAPE-LDSVDCSSH
SESEQFPRRT-NETQLSPSP---SHQKSPASIQLPCNTTTREVCPD-Q--EGPAELDG-T
FAVSILVERAMHLSLKGSPLTERKVLI

PF00168 // ENSGT00510000048072_0_Domain_3 (1888, 1953)

PSCCVSFATA-DEPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLMHFKEERQSRRGMETPGS-LIPLYIY------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGPGSGGSHGRKK--
---RGLSDISPSTSLPPLVEGQLRCFLRLTINKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLDVITKSDHLPIGRVQISG
LAQLSPTHQINGLFTIISPTSKKLGDLQVSLALEPLSETYDSYSPLPITDMVENVLLSEQ
GFRGNTK-------------------NIRIAGKELVANSS-RSTTP---RGKDHLYFPEN
SNTGKDSFFGLQHHLNSGQSLE-----SVTLKGKAP-RKRMSLLNSSEFQPQIRTVAKSY
SDSCVLPSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSMM-LDNVHPPLKEDSLR
SST-------------R-LKA-LSNNQFKDHIEDHLLPPTEN---------------TLL
LGSAELSQGHFWNGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLEKLFYTA-PKSDGSIS
DVLCEDDGRVPSKKLNQSKALGRSSKALEPNDQKLKRA---------SVEENRNL-----
VE-QMTSEIPEDAPVMTLSVARLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKPFAGRS
AKLIT--------AKKCTFFVEYHFPVGFSKSKLGKTALITEVVRLASSKITDG-MVKFQ
QRFVFPVQFNGPMIEHWWNSKLTFQIYAKKPPQKKPELVGAASLILRAVIQSKLLSFSDQ
LPVQQENG---QVLLGPLKVTMELVIDNKDFADVNTELT-SSTQQAPLSVVTSPNKILLE
TSQDNTC---------TTDLQNTNQVHEETAKKAQRLILSNAKPPSPVATNSS-AFMSVP
ASHNLVNQANGSAKENALLLYVLLMVPDGKDFITGESEKQP

PF00168 // ENSGT00510000048072_0_Domain_1 (1002, 1087)

PCNVYLTCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---IIPVSLSSKHLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKIFHLLLDAKYPVIAVDNYMPVIDVFSGHQNGSLRVFLAMGSSDQIMTL
QRLRNEEGTL-YPFSPKPSHFLDQPS-VASQ--AEGKGNVLMEHHFEFHIMMVKGLAPL-
--QSTVWGEADCYVQYYFPFQDSQSSVLKEPDFLENGITLKPFRTSTTLCVPDPVFNSEH
HHSLLLPTEVPVQRLLLSAFMSQGLLPGGGVQFEIWCRYSMPRKEPNL------------
-CLGRK------------------------------IMPRQNSPK-AQG-QSP-----GP
EFKS--------------------RDRQKSMAADEALAEQDPALQFSATVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSHYIE--LPCNLVTQHSSGEACFLAELLEFAEITF-AI
YHENTKSVGDIISLHSCKEHLL-GVVKVPTKDLLVKR-SGITGWYPVILPEDEGLPHGLE
FMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----SGLKDLVKMDEE---E---P
AIVTISTPRLWLPTHCVLLAGHKYIHKNTYFYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKVSKRAEVTRCPSLLWYFREERLEIQVWRAYGNDS-VERPQQTDSWIGSAYVDLARL
GDRSTRTLTVSGVYPLFGRNASNLFGAALRVHVVLSSL---SPHMEPAHD-QDSMDYSSH
SESEQLPSRN-DEIQLSPPG---DHEKSPAPTQVLCTSTAAEVCQP-N--EGHTELDG-T
VAVS

PF00168 // ENSGT00510000048072_0_Domain_3 (1865, 1974)

ILVERAMHLSLKGSPLTERKVSIPSCCVSFATA-SEPSPVYTHVIENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLVHLKEEKQARRGVKTPAS-LIPMYNP---FSFPASNLCTAFPSL
IPKQSQDQFTRTSSKELDFSSS-----E---RSSTKRSQALRHEQHVQNIRRFHESLQ-Q
GEAILTRDDKQTTSPLS-SHTSILTSLRKNLSELDQIQQYFNQKLSRPSLPLSPPTHPAI
IQCLESRKEHLRPA--TS-SLDP---ESQCILEKSSSLVLQVSSLIADLQTIT--RNS-Q
AALTSHRAK---SRSTA-TAVPDTQDTETVRERSTTPD--KPLAIEEDT---NSLPPALE
ETAGG-REMFHEALEQTVPVTRMQS-------------------S---EDPETGPAFSDE
DYEEDVIEPRTLNEITTVTDKTSPWSSFVSDIS-EVISPQPDEVQRED-SYPS-EPFPS-
QELEVRS------KKAI-----------NPHLPGQGSPSQRLVAYEGGVPKDKVG-EPT-
STNHQLNPHLSLPGVQQSNAFVEWS-SP--PGDHYKEDKAEAQTENEA------ASS---
-------------ELSDS-------------SDSF-EKF--PLQIISQRKGENYKESPMD
------------------------SPDIQETQVTTESEV-STKQTL----LPEPIVVPNF
FLPPQQLEASMRMLSLSTGLPPAAAADQDKKE----AL---------SRRPTRPRPISL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGPQHRLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSASLSLRAIIQSELLSFSDQ
LPVQQENG---QSPFGPLKVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPS-TFVATP
ASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQK------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAVRTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IVLPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAEHLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQFM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEVISCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----GR---SDTTRSQASRHEEHVQNIRRFHESLHLQ
GEAPLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQDTEALQERCTMPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHAVPITRMQG-------------------S---EDTEAGPDYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSVISDTS-EVISPQPDEVQREGPSCPSPGPFCR-
EELMVKSSFLSSPERAV-----------NPHLPRQSSPSQSLVACECKASKARVGGESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QTDQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRRENHKGPPID
------------------------SSDIRQRQVTTGSET-STKQSL---LLPGPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------DMAVLVLEVITKLDHLPVGRVQIGG
LAQLSPIHQINGFFTIVSPTSKKLGELQVSLALEPLSETYNSYKPFPTTDVIENV----Q
GVRENIGLGDTQFLVPSR---SHRIPPTKIDGKELATNSS-RPTTP---RGKDHLYFVEN
PDTVRDSFFGLQHHLNSGQTLE-----FVTLKGEAP-RKQMSLLNSSEFQPQTRTVAKSH
SDSCILSSNTPPTKDLLSALIEQGNKLRNAMVVSTMKSSPNTSML-LDEVHPQVKEDFLR
TST-------------Q-IKT-LSGNQFKDHIEDHLPPT--ENTFWKHDTKADSRAIQLL
LGSAELSQGHYWDGLGSPPDSPSPGSDEYCSSELNDPQYDQSLLENLFYTAPPKSDTSIS
DYLSEDDNIVTSKTMSQLKPPARSPKVLESSDHKLKKR--------ALSKKNRNL-----
VEEEMLSETPKDAQMMTLSVDQLALLGRTHSVRIIIETMAVPPDSPEM-IPGKKSFPGRP
PRPTT--------AKKRTFFVEYHFPVGFSKNGLGKTALITEVIRLASSKITNG-MVKFQ
QRFVFPVQFGGSMIEHWWNASLTFQIYTKKSPQKKPEVIGSASLPLRAVIQSDKLSFSDQ
LPVQQENG---QAPLGPLKVTMELVIDNKDFTGINTKLN-HSTQHTPLGAHTNSDKIVPE
ASQDITW---------DRKSQSPKQIYEETAKEAQNFVHHNPKSPSPIESKPS-TFMTVP
ASHNLINQTNESTKESPLLLHVLLMVPDGKDFITEESAKQPSCNIYLNCKLFSTEEVTRS
AIAWATTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQFYVSFKDPKISRLLLDAQYPVVAVDSYMPVIDVFSGHQTGSLRVFLAMGSSVQIIAL
QRLKNEEGTL-PTFNPRPAHFLDQPP-ITSVTMAEGQGHGLMEHHFEIHVEMVKGLTPL-
--QATVWGEADCYVQYYFPAQDSQSSVLKGPAFLENEITLKPFRSATTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSAQGPVPGGGVQFEIWCRYYYPNVRDQM------------
-VARGTLPL-SRICAIVTMQ---HREDVGIQTFNLPLTPRLENRKELKN-QSSGFLDVGL
RYRRTPRTAEGVLAARAVSISVHIIRACGLQAAAKALAEQEPTLQLSATVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHTE--FTCNLVTQYCSGEACFLAELLEFAEVIF-AV
YHEDTKSASDIASIQPPKDYLL-GIVKLPTKDLLVKR-SGITGWYPIIFPEDGVLPHSLE
LMQKIVGGLEVSVSFTHPGDRERVLEAAELLGWNFQ----NSLTDPVKMNEE---E---P
ATVTISTPRLWLPIHCVLLAGQKYIHKNTYCYLRYKLYDREGFWTPLRKPKESTNKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDMSRL
GERSARTLTVSGVYPLFGRNSSNLSGAALRVHVVLSSL---SPHPGPTRE-PDSMDVSSH
SEDEPLSR-R-DEIQLSPPH---GIQKSPP-AQVPCSSPTAEVCSA-Q--EDPTELAG-T
FAVSILVERAMHLSLKGTPLTER

PF00168 // ENSGT00510000048072_0_Domain_3 (1884, 1952)

KVSIPSCCVSFTTS-DRPSPVYTQVIENTDSPIWNFQ
QQSRLPKELLLDPQKMLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFGG
ECQGQIKVAISPLESLMHFKEERQTRRGVETPGS-LIPKYSP---FSFPASDMCAAFPSC
IARQIPEQPTHISSKELGFSSP-----G---KSGISRSQALRHEEHVQNIRRYHESLQ-Q
GESVLPGDDKLSTSPLS-SHTSLLNSLRRNLSELDQIQQYFSQKLTKSFLPLSPQTHNAI
LQCQESNEDHHEPE--AS-VLNP---ESQCILEKSNNLVLQVSSLITDLQTIT--RNS-Q
ASLSSHQAR---SRSKEVTTLPNVQDREAIQEQSRTLE--KSLARAPDDGTNSLPSPICE
ETPSG-RGMLCESLGHIAPINDAVSLVF--------------TRKQNCEDIEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-EAISLQSDEAQRESPSYPSSEPFPR-
EKLKVGSSTLSSPGKDI-----------NPHLPLQGSPSQSHVPYEDEASKARVG-EPA-
SVDPQPIPHLTLSGTQQNNTLVGWS-LS--RAGYDKELKPEAQAENEA------ASS---
-------------ELSDS-------------DDSF-EKF--SPHLASQSKRETCRVPPID
------------------------SPHIRQKQMTTGSEV-STRQSC---LLPEPIVVPNF
FLPPQQLEASMRMLSLSAALPPQTMADQDKSEASRGAL---------SRRPCRPRPNPL-
-------PPHLPEEETRR---IARI--FSSHYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLSSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG

PF00168 // ENSGT00510000048072_0_Domain_0 (775, 833)

-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQS

ENSGT00510000048072_0_Linker_0_1 (833, 1000)

ELLSFSDQ
LPVQQEND---QTVFGPLKVTMELVTDNKDITGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGAVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKQLRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1885)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSILVERAMHLSLKGSPLTEQK

PF00168 // ENSGT00510000048072_0_Domain_3 (1885, 1974)

VLIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLAKAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSSERAV-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPQPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLTLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MVSKPPATVLIRVRWWGETSDGT
LFIPRNTSQTEQKAVKTTTHYAIRCGPKQFASYLTDMGVLVLEVMTKPDHLPIGRAQING
LSQLSPSHPISGFFTVTSPTSEKLGELQVSLVLEPLSETYDSNSSIPTTDVSLDIAASAQ
GTKGMTDSSKAEFLASAQL-----RGLPGMTGRESG--NSSRAATP---RGIDHLFFQEN
SENIKNGFS---------GSQHHLILPDENLKMTPL-KKQASFPNSSDLEVQAGTPMGSH
RNAHVLSLHNPATKDLLSALLDQGNKLRNAMAVSAMKCSPDTDIE-IHPIKRET----FK
A-------------TAKSLKT--LHPDVISTDEDPTLLASE-YTVQEFDVHAENRAIQLL
LGSADLSPVRFWDGIGSPPESLSAGSEVY-DSELNDPHYDQSLLENLFYKA-LKSDTSLS
DFLSEDEDVTSSEKEIRTKKLVKGDHRNHQRSQKTSVSNICDQKEKATEMKCSCSPAGPL
PLSDTRTEYAEEGQTINLNVDRLALLGRIHLARVIIESLRIPPES-TQSTPGKKSFTGKP
PRPML--------SKKRTFFVEFHFPVGVSKNESGQISLTTEVIRIASSKITGD-VVKFQ
QRFVFPIHFGGIMIAHWWNSDLAFKIYMRKITQKKPVLIGSATLTLRKVIQSELLTISYE
LPVEGEGG---QSQIGPIKISLELAADNKDFTSANARSA-SIVHQAPVYAIRSPGIKLQE
ADRNVMH---------AKSPQLLKQSNQESFKRTEVPT----T--GMLQ--TP-LSIPLS
VSHNLMTQINE-SEEDGLLLHVLLMVPDGKDFVAGDSGIHGPCNVYLNCKLFSTEEATRS
AVMWGTTQPAFSFSQ---VMPVSLTTRYLERLKNNVMVIEAWNKMRTPGCDRLLGLVKLP
LHQFYMSFKDTKISRLLLQAHYPVVAVDSYMPVIDVFTGSKNGSLRVILAMGSADQIVAL
QRLKNEDGAV-PPIMKRPPHSLDPL-PASPAMQLEREEEGLIEHVFEIHVENVKGLTPL-
--QSTVWGEADCYVQYYFPVQEPDTSTLQGTKLYENGIKLKPFRSATTLCVPDPIFNDEQ
HHSLLVPADVPVQRLLLSAFSSQGLAAGGGIQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRLCAMVTMQ---HREEVGIQTFTLPLVPRTDCSEELHP-RSSGLLDVSV
RYKRSLKPAEGAIASRVISI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1471)

SVQIHRAAGLQAAARAVAEKNPSLQSTAEVGVNAYVSMHL
SFLPEEKKRTTRAVARTFCPEFDHHTE--F

ENSGT00510000048072_0_Linker_2_3 (1471, 1872)

SCNLIIQRSSGETCCLGELLQSAQIVF-CI
YHQNIKSATGSMKTQKSRDYLL-GTVRVPTKDLLIKR-SGITGWYSVTLPEELMPSHCTN
IMETIVGGLELSITFAHHDDRERVVEAAKLLGWNQEENHEDSMD-----DDDDWYQSKNP
ATVTISTPRVWLPVHCILLAGQTHINKSTYSYLRYKLYDQEAIWTSLQRPKLTEDEKHVT
VMYKKTKEVKLTRNQAMLWYFREEKLEIQVWRAYGKENKVERPLDTDRLIGSAFVDLAAL
GQRSRKTLTVSGIYPVFRRNASNLSGAAVRVHITLTCT---HAHITSICG-SECAEDVSN
SEDEGAGEVSDTGQQVLKNH---NHKLNSTSSEIPSVK--------PSE-ETNREALENT
FAVTVLVERAM

PF00168 // ENSGT00510000048072_0_Domain_3 (1872, 1953)

HLSLKGSPLTERGVTAPSSYVTFAVA-DADAPIATAIIENTDSPVWDFQ
QQTRLSKELLLDPQQTLVFKVWHKA-EVERVIGFATVDLSPLLSGFQLVCGWYNITDLSG
QCRGQIKVAISPLESIIHLKEVRQARIRTKAPGS-SIPAHSP---FSFEARTFYTAFPNY
VTRYPG-QLLSTSSKDFT---------TQERRISPTETWTPRHEEHMQNVRRFHESLQ-Q
VEGNAQKAGRVDSLSHS-SRTSLLSALR--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RGIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-SRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGTP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALVTEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKDFTGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNESTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYKRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
CHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYK-
EELTVKSSFLSSPERAI-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPQPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPIN
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAV---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVIWKIAKPP-TSVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTGMLLFCRLNC-KA------------
--NMKPTCYQQS---------K----V---LWHNPLVDLKICYLNWF-----NK------
-------------TLIDQK-YRWGNQ-TKDDGKE--------------------------
------------------------------------------------------------
----------------------KGRE----------------------------------
---------------------------------RRVLSERE-SSF--TEPSVNIFAFVFL
VSSTELSHGHFWNGLGSPPDSPSPGSDVYCSSDLNDPQYDQSLLENLFYTV-PKSEVSAS
DFLSEDDNMEPSKTMNQSKASGRSSKVVGSSEHQLRKR--------ITV-KSRNV-----
TDKEVPLRTPGPTPATSLSVDRLALLGRIHSVRIIIETMGVPPESPHM-TPSRKSSAGKP
PKPAATT----SAA-KNTFFVEYHFPVGFSKSGLGKTALITEVVRLASSKVADG-VVKFQ
QRFVCPVEFGGPMIEHWWNSNLTFQIYAKKAPQKKPEVIGSASLPLRAVIQSELLSFSNQ
LPVQQESG---SSSLGPLKVTMELVLGNKDFTGVSAKLR-SSTQHTSLSAATSPDMILPE
TLQDTTC---------TKNPQNSNQVHEETSKKTQNLVLSNPKSANPIAS-NS-GFMTMP
H-HHLAHQTNGSSKENTLLLHVLLMVPDGKGFVSGELEKPPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNIYLKCKLFSTEEVTTS
AISWGTAQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGTL-PPFSPRPAHFLDKPP-VTSVAMPENQGNRLMEHHFEFHVVMVKGLVPL-
--QATVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLRPIRTPTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSSQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGMQNFNLPLTPRLENSKELKN-QSSGLLDVGL
RYRRSPRTTEGVLAARAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FPCNLVTQHSSGEACFLAELLEFAEIIF-AI
YHENTKSVSDIARIQSCKEYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDDGLHQDLE
FMQKIVGGLELSVSFTHPGDRERVLEAAELLGWTFD----SSLMDLVKVEEE---M---P
ATVTISTPRLWLPVHCVLLAGHKNIHRNTYCYLRYKLYSQEAFWTPLRKPREATNKNQVL
ITFKASKRAEVTRNQSLLWYFREEKLEIQVWRAYGNDS-LERPHQTDSWIGSAYVDLSRL
GEKSTRTLTVSGVYPLFGRNASDLSGAALRVHVVLNPL---SPHTEPTRQ-LDSMDCSSH
SESEQLPRTN-DELQLSPPR---VLHKSPASTQVGCNSTAAEACPA-Q--EGPSELDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVPIPSCCVSFATA-TEPSPVYTHVVENTDSPIWNFQ
QQSRLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLLHLKEERQTRRGTAAPGS-LIPLFSS---FSIPASSMCDTFPGP
IARHIQDQLAHTSPKEVDFSSL-----A---RNDTIRSQAARHEEHVQNIRRFHESLQ-H
GEAVLASDEKWATVPLS-SHTSILTSLRKNLSELDEIQKYFTQKLSKPFLPFSSHSSP-I
SKSLESQRDCVGPGT--N-SQDP---EDQCILEKSSNLVMQVSSLISDLQTIT--RDS-Q
AALASHQAR---SRSRAVTTLPEAQDTEALQGRSATPE--EPLSVAGEASTNSLPASVLE
EMSEGGGGVLRESVEHTVPIARVQS-------------------S---DDTEVNPDLSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFTSDVS-EVSSPQPNEVQREGSSCP-PRPFPT-
EEFKVRSSLMSSPQKPV-----------SPQ-AGQGSPSHS-IACEGGACKTKTE-ESA-
SAQPQLVPGLTVSGAQESNDSVARG-SL--QIKQDRRPMPEILAEREA------FSS---
-------------EFSDS-------------SESS-EKF--PLHLPSQSKRENLKEPPMD
------------------------SPSVRQKQVTTGPGV-FTRQSL---LLPEPIVVPNF
FLPPQQLEASLRMISHSPALPPPATTDQDKSETTKGAL---------AQRPCRSRPYSL-
-------PPNFPEEETRR---IARI--FSSHYSQKPDEA---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGPGAGGGRSRKKK-
----GLSDISPSTSLPPLVEGQLRCFLRLTISKILWMVVKPP-TPVLIRVRWWGETSDGT
IFCPRDATLIEQKAVKTTTRYAIRCGPKQFASYLTDMAVLVLEVITKSDHLPVGRAQISG
LSKLSPTYPISGFFTIVSPTSKKLGEIQILLVLEPLSATFDNCSSI-TTDMSGDALLLDQ
GFGENIEPSKVQLSGMTR---AHTLPT-STGGKESL--TSSRTTTP---RGKDHLYFPQN
P--VVDSFLGPQPHLNSKQHIE-----DETVEQEPV-KKQVSCPTISVHDTHIRRAAESQ
SDSQVHPLNKPPTKDLLSALLEQGNKLRNAMVVSTMQSCPDVVNM-LTEVPPPRKQSVKS
LAHVKLSSGVGP----Q---N-PVIAETMPTIEDSLFPPQ--SAFHEHDSQVDAKAIQLL
LGSADKSSRHYWDGLGSPPESLSPGSDAYCSSELSDPQYDLSLLENLFYMT-SKADSSVS
DVHNE-DDKIPPEKIVQSRSIAQNPKAVNLGHHSPKKT--------AMGKKAKNS-----
AVQSTHLQSPRKTEVITLNLDRLALLSRIRSARVVIDVLGVPPESPQM-TPGKTGIPARP
PRSSS--------AKKRTFFVEYQFPIDASRSDTEEISVTTEVVRLASSKITGE-VVKFQ
QRSVFPIHFDGAMIEYWWKSDLTFKIYMKRSTQKKAELIGSAVLPLQEVICSQLLTFSGQ
LPMEEKS----QASFGPLKLSVQLAVDNKGASGTNSKLL-SAIQQPPVSILTSPTKQFPG
TNQSATH---------DKNLQAWTQVNEDTSKQKQ---HWGPDPTVMKPSGPR-TVSPLS
PSNSTRIPIDKSTEEKPLLLYVLLMVPDGKDFITGTSEKQQTCNVYLNCKLFSTEEVTRS
AIIWGTTQPNFNFTQ---VTPVSLTPKYLERLKNNVMVIEAWNKVRSPGQDKLLGLVKLP
LHQFYISFKDPKISHLLLEAQYPVVAVDSYTPVIDVFTGHQNGSLRVFLAMGSANQITAL
QKLKNEDGPV-LSYSTRPPHFLDQSA-PPLVMQRDGQGDGLIEHQFEIYVEKVKGLIPL-
--QSTVWGEADCYVQYCFPVQDSKDSTLKGTKLPQSGITLKPFRSATTLCVPDPIFNHKY
LHSLLLPPEVPLQRLLLSAFSACGLVPGGGIQFEIWCRYYYPNVREQM------------
-VARGSLPL-SRLCALVTMQ---HHENVELQTFNLPLFPRSENKNEFQA-QTAGLLDVSL
RYRHTTRTSEGVIAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1471)

SVHIHRASGLQAAARVMAEQEPSLRYSATVGVNTSVTTHL
SFLPKGEQRQTHPVARTFCPEFSHHIE--F

ENSGT00510000048072_0_Linker_2_3 (1471, 1885)

PCNLVTQHSSGEACFLAELLEFAEIIF-SL
YHQDTKPGYQSDHIQPLKEYLL-GVVRIPMKDLLIKR-SGITGWYPVILPEDLAAAQNTD
IMQMIVGGLELSVSFAHSGDRERVLEAAKLLGWSFEEDPTD----LLTDV-EQW-----P
ATITISTPRAWLPTHCMLLAGQTHIHKATHCYLRYKLYDQEGFWTPLRKPKVTTDEKQVT
VTFTTTKKVDVNVGPSLLWYFREEKLEIQVWRSYGNDS-VERPHLTDTLIGAAYVDLSRL
SVKTAKTLIVSGVYPVFGRGASDLSGAAVRVHIVVTAEKS-TFPPGPAHQ-INYTEDSSN
SDSERISHQE-DPVEPEN---------KSDSKKLDCSQGPQAKSPPAE--TGTADLEG-T
FAVSILVERAMHLSLKGSPLTERN

PF00168 // ENSGT00510000048072_0_Domain_3 (1885, 1953)

VTAPSCCVSFAAT-DVRSPIYTHVVENTDSPVWDFQ
QETRLSKELLLDSQQTLVFKVWHKA-DVERVIGFASVDLSPLLSGFQFVCGWYNIADFSG
QCQGQIKVAISPLESIIHLKEERLARQGTKVSELSQIPKYSP---FSFFAS----AFPSC
MGRYNLAQPIHGCSKDINVSSP-----R---RSGPVRNQVSRHEEHMENVRRFHESLQ-Q
AEGIIHNDSQENSLAFA-SHNSLLTSLRKNLNELDQIQRYFNQKLTKSYPQLTFSHSVQP
P--QESRDNHREAE---AGSLNL---GSHNILEKSNYLVSQVSALINDMQTLT--KDS-H
SSL-NHQGESENPESK---SLLRIHRAEDKGTSIAALS-------------QAASPVPPE
IAPLG-KETLGKFLEQETTENSLPLALEVIELEE---------------DSEVAQTSSDG
DYEEDFIEPRTLNEITTVTDKTSPWSSVASEDG-V-VDLLPGEIKEDGLSPPPPEQPPK-
EGQNKNN-CQPRLQQDSHQPLPH--RTPSPPVAEA------DSICRGSPD---VV-----
-I------------YPENSRAVGISQEEGPNKSRRFSLVPEA-----ALQEPLDSNE---
-------------------SCEEKDS-------GHDQKL--LAK-ASS------------
------------------------SSSEKPNVLLVESEK-SPKQSL---LLPEPLVVPNF
FLSPKHLEESMRMLSLSAASPSI-TTRQGGSEPTKSIH---------YQRPGRPRPNPP-
-------PPDLSRKEAQR---IAKI--FSAQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MAVLVLEVITKLDHLPIGRVQISG
LAQLSPTHHINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYNPLPTTDMTENVLSSEQ
GFKECTEPSNTQFLIPSR---PHRLPTTKIDGKELAANSS-RSTTP---RGKDHLYFAEN
SDTIKDSFFGL-HHLKSGQSLE-----SMTVKGKAP-QKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDTSML-LDEVHPSMKEDFLS
ASTHNL---------------------------------IN-NTFGKHDTKADTRTIQLL
LGSAELSQGHYWNGLGSPPDSPSPGSDVYCSSEPNDPQYDQSLLENLFYTA-PKSDTSIS
DFFSEDDDTVPSKKMSQSKALVRSPKVPESNDQKLKKR--------AVGKKNRNL-----
VEQQMLSETPEDAQVMALSVDRLALLGRTHSVRIIVETMGVPPDSPQM-TPGKKSCPGRP
PKLTT--------AKKRTFFVEYHLPVGFSKSGLGKTALITEVVRLASSKITEG-VVKFQ
QRFVFPVQFGGPMIEHWWNSNLAFQIYTKKTPQKKPEVVGSASLPLRAVIQSELLSFSDQ
LPVQQEGG---QTPLGPLKVTVELVIDNKDFTGVTTKLS-SSTQRTPLCAFTSPDKTLSE
PSQHVTC---------TKNPQNLNQVHEEAAKKAQNLVFPNPKSPSSVAPNPS-TFMAVP
ASHNLVSQTNGSTKESALLLHVLLMVPDGKDFITGESEKQPPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQFYMSFKDPKISHLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-PPFSPRPPHFLDQPS-TASVALAEDQGNGLMEHHFDLHVDKVKGLAPL-
--QATVWGEADCYVQYYFPVQDSQSSVLKGPEFPENGITLKPFRSATTLCIPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLTPRLENRKELRN-QSSGLLDVGL
RYRRTPRTAEGVLAARAVSI

PF00168 // ENSGT00510000048072_0_Domain_2 (1401, 1472)

SVQIIRACGLQAAAKALAEQEPALQFSATVGVNAFVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FS

ENSGT00510000048072_0_Linker_2_3 (1472, 1884)

CNLVTQRCSGEACFLAELLEFAEVTF-AI
YHEDTKSASSIASIHSLKEYLL-GVVKVPMKELLVKR-SGITGWYPIILPEDGPLLHGLE
LMQKIVGGLELSVSFTHPGDRERVLEAAELLGWSFE----NNLKDLVKMDET---E---P
ATVTVSTPRLWLPIHCVLFAGQEHIHKNTYCYLRYKLYDHEGFWTPLKKPKESTNKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAFGNDS-VERPHQTDSWIGSAYVDLARL
GERSTRTLTVSGVYPLFGRNASNLLGAALRVHVVLSSL---SRHPGPTPE-LDSMDCSSH
SESEQLPRRN-VEIQLSLSP---GHQESPASAQVPCNSTTPEVCPA-Q--ECPAELDG-T
FAVSILVERAMHLSLKGSPLTER

PF00168 // ENSGT00510000048072_0_Domain_3 (1884, 1952)

KVSIPSCCVSFTTA-DKPSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPSESLMRFKEERQARRGVETPGS-LIPMYRP---FSFPASDMYAAFPSC
VARQTLEQLAHTSSKELDFSSP-----R---RSSAARSQASRHEEHVQNIRRFHESLQ-Q
GEAVLPSDDKLSTSPLS-SHSSILTSLRRNLNELDQIQRYFSQKLTKPLLPLSPQTR-AV
LQCQESHRDHLRPG--AS-SLDP---ESQCLLEKSNNLVLQVSSLITDLQTIT--RNS-Q
ASLSSHQAR---SRSREVSTLPDAQDTVATQERSTTPD--QPLAGAPDEGRNSLPPPALE
DTSSG-GGMLRESLGHTIPITRMQS-------------------SEDT---EAGPAYSDE
DYEEDIIEPRTLNDITTVTDKTSPWSSFMSDTS-EIISLQPGEVQKEGPSCPS-EPFPR-
EELKGRSSPLSSPERTV-----------SPHLPRQGSPSQSLVLCEDKSPRARVG-EPA-
SADPQLISSMTLSGAKQSNTFVDWS-SP--RVDQDQEPKPEAQAGNEA------ASS---
-------------ELSDS-------------TDSF-EKF--PLHLASQSRRE-NKGPPIK
------------------------RPDNKQKQATSGSEM-STRQSL---LYPLPIVVPNF
FLPPQQLEASLRMLSLSAALPPPATTDQDKSEATRG-----------TQRPCRPRLNSL-
-------PPSLPEEETRR---IARI--FSSQYSQK-------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINKVVWKIAKPP-TSVLVRVRWWGETSDGT
LFCPRDALQTEPKVVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPVGRVQISG
LAQLSPTHQINGFFTIVSPVSKKLGELQVSLALEPLSDTYDSYKPLPTTDMTENVLLSER
GLRENTESSNALSMIP-----SCGEPAIKTEGKELAGTSS-RSATP---RGKDHLYFAED
PDAVKSSLCGPQHHLNSEPSLE-----TVLLRGKAP-QKQMSLLNSSEFQPQISTVTKSH
SDSFILSSNNPPTKDLLSALLEQGNKLRNAMLISAMNSSPDTSML-LDKAPPPMLEDGFR
SS-V------------P---N-SSKNQFKDHSGDHLLPLTE-N-----------IAIQLL
LGSAELSQGHFWNGLGSPPDSPSPGSDVYCSSDLNDPQYDQSLLENLFYTA-PKSEVSAS
DFLSEDESMEPSKTVNQSKASGRS-KVVGSSEHKLKKM--------AAVKKSRSV-----
VDEQVLSRIPGHTPATSLSVDRLALLGRIHSVRIIIETMGVPPDSPHV-TPNRKSFAGKP
PKPFFF--------SSSTFFVEYHFPVGFSRRGLGKTALITEVVRLASSKVADG-VVKFQ
QRFVCPIEFGGPMIEHWWNSNLTFQIYAKKAPQKKPEAVGSASLPLRAVIQSELLSFRNQ
LPVQQEHG---SSALGPLQVTMELVLGSKGFTGVSAKLS-SSTQHTPLSAATSPDMA-RK
TLQDTTC---------TQNPQNSNQIHEETSRKTQNLVLPNPKSANPVSSNSP-DVMTVP
H-HSSVHQTNGSSKESALLLHVLLMVPDGKDFVSREPEKPPP

PF00168 // ENSGT00510000048072_0_Domain_1 (1003, 1084)

CNVYLKCKLFRTEEVTTS
AVSWGTAQPVFNFSQ---VIPVSLSSRYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMML
QRLKNEEGTL-PPFSPRPAHFLDQPP-VASVPMPEGQGNRLMEHHFEFHVVMVKGLVPL-
--QTTVWGEADCYVQYYFPFQDSQPSVLQGPDFLENGITLKPFRTSTTLCVPDPIFNSEH
HHSLLLPTEVPVQRLLLSAFSSQGLVPGGGVQFEVWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTME---HREDVGMQNFNLPLTPRFENSKELKN-QPSGLLDVGL
RYRRSPRTTEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPAVQFGATVGVNASVTTHL
SFLPKAEQRRTRPVACSFCPEFSHHIE--FPCNLVTQHCSGEACFLAELLEYAEIIF-AI
YHENTKSVSDIASIQSCKDYLL-GVVKVPTKDLLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

VILPEDEGLPQDLE
YMQKIVGGLELSVSFTHPGDRERVLEAAELLGWTFN----NSLKDLVKMEEE---V---P
ATVTISTPRLWLPVHCVLLAGHKNIHKNTYCYLRYKLYTQEAFWTPLRKPKESTNRNQVL
ITFKASKRAEVTRSQSLLWYFREEKLEIQVWRAYGNDN-LERPHQTDSWIGSAYVDLSRL
GEKSARTLTVSGVYPLFGRNASDLSGAALRIHVVLSPL---SPLTEPTRD-LDSMDCSSH
SESEQLPRKS-DELQLSRPC---VLQKTPASTQVSCNSAAAEVCPA-Q--EAPSELEG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSVPSCCVSFVTS-TEPSPVYTHVVENTDSPIWNFQ
QQSRLSKELLLDPHQTLVFKVWHKG-DEERVVGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLESLMHLKEERQARRGTVAPGS-LIPLFSP---FPFPASSLCDTFPGP
IARHTQDELAHTFPKEVDFSSP-----A---RNGAIRSQVARHEEHVQNIRRFHESLQ-H
GEAVSAGDEKLTTVPLS-SHTSILTSLRKNLSELDEIQKYFTQKLSKPLLPLSSPSSPVL
SKSQES------PGA--S-SQDP---ENQCILEKSSNLVLQVSSLISDLQTIT--RDS-Q
AALASRQAR---SRSRAVTTLPGAQDTKAMRGRSTSPE--EPVAGVGETSTNSLPAPVLE
ETSEGG-RVLRESVEHALPVTRVHS-------------------G---EDTEVDSDLSEE
DYEEDFLEPRTLNEITTVTDKTSPWSSFMSDMS-EVFSPRPSEIPRE-------GPFPR-
EELKVRSSSMSRPQKVV-----------NPQ-SVQDSPSQR--PSEGGACKTTVE-ESA-
STKPRPVPGLTFSEAQESNDSVGQS-SP--HINEDKRPMPEILAESEA------ISS---
-------------ESSDS-------------SE-----S--PLHLPSQSERGNHKEPPKD
------------------------FPAVRQNLLTQE--------LS---SSPEPIVVPNF
FLPPQQLEASLRMISHSPALPPPATTDQDKSETTRGAL---------AQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSKYSQEPHEA---------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGGGRRKRD
S-SLGLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGKVQISG
LAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYNSYNPLPITDMAENVLLPKQ
GSRENTESSHTQFLIPSRS---HGVPILKNDGKELGANRS-RSTTP---RGKDHLYFVEN
SDTIKDSFFGLQPHLNSGQSLE-----SVTIKGKAP-RKQMSLHNSSEFQPQIRSVAKSH
SDSCILSSNNPPTKDLLSVLLEQGNKLRNAMVISAMKSSPDTSML-LDKIHPPIKEDSLR
PS-T------------Q-IRV-LSKNQV----EDHDLPSTE-DAFWKHDTKVDTRAIQLL
LGSAELSRGHFWNGLGSPPDSPSPGSDVYCSSELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEDDDVVPSKNMNQLKALGRSSKVLESSDQKLKKK--------APGKKNRNL-----
VEQQMLSETPENTQVTTLSVDRLALLGRIHSVRMFIETMGVPPDSPQV-TPGKKSLTGRP
PKLTI--------AKKRTFFVEYHFPVGFSKSGLEKTALITEVVRLASSKITDG-MVKFQ
QRFVFPIQFGGPMIEHWWNSNLTFQIYAKKMPQKKPEVIGSAALPLRAVIQSELLSFSDH
LPVQQENG---QTPIGPLKVTMELVIDNKNFTSVNSKLN-SSIQHTPFCASTNPDKILPE
PNQDTTY---------TKNSQTLTQILEETTKEAQNLVFPNPKSPSSIVPNSS-TSMAVP
TSHDLVNQTDMSTKENALLLHVLLMVPDGKDFITGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVSRS
ITVWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAKYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKKEEGTL-PPFSPRPAHFLDQPS-VASVALAEGQGNGLMEHHFEFHIEMVKGLVPL-
--QTTVWGEADCYVQYYFPFQDSQSSVLKGPEFLENGISLKSFRTATTLCVPDPIFNSEH
HHSLLLPTEIPVQRLLLSVFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGILPL-SRICAMVTMQ---HREDVGIQTFNLPLTSGFENRKDLRN-QLSGLLDVGL
RYRRSSRTTEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQDPALQFSATVGVNASVTTHL
SFLPKGEQRRTRPVACSFCPEFSHHIE--FPCNLVTQYSSGEACFLAEQLEFAEITF-GI
YHENTKSVSSIASIQSCKEYLL-GVVKIPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VILPEDGDLPHGLE
LLQKIVGGLELSVSFTHPGDRERVLEAAELIGWNFE----NSLKDLVKMDEE---E---P
ATVTISTPRLWLPMHCVLLAGHTRIHKSTYCYLRYKLYDHEAFWTPLKKPKESAVKNQVM
VTFQASKRAEVIRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTISGVYPLFGRNASNLSGAALRVHVVLSSL---SPHTEPTHE-LDSVDCSSH
SESEQLSRRN-DEIQLSPPG---GHQ-KSASTQVPCNSTTSEVCLA-Q--EDPAELER-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVSIPSCCVSFATA-DEPSPVYTQVIENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLMHFKEERQARRGVETPGT-LIPIYNT---FSFPASDMYAAFPSH
IVGHIQDQLVHTSSKELDFSTP-----GKSGTGGTTRSLATRHEEHVQNIRRFHESLQ-Q
GEAILTSDDKLTASPLS-SHTSILTSLRKNLSELDQIQKYFSQKLTKPFLPLSPHTHTAI
LQSQENHGDHIGPEA--S-TLDP---ESQCILEKSNNLVVQVSSLISDLQTIT--RNS-Q
AALTSHRAR---SRSREVTTVPDAQDIEATQEQSTTPN--KTLARAAAKGTNSPSPPALE
ETSNG-GGMFHESLGNMVPIT-----------------------S---EDTEVGPLYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPHEVQKEGPSSPSPEPSPRA
EEIKVRSSFLSSPEKAI-----------NS-LPRQGSSTQSVAYED-RDSKTGVE-QSN-
LTSPHVFPHLKCSGIQQSNTFVGWS-SS--QANQDKEPEPEAQAEDGA------VSS---
-------------ELSDS-------------TDSF-EKL--SVHIASQSKRED-KEPRIH
------------------------CADIRQKQVTTGSEV-STKKS----LLPEPIVVPNF
FLPPQQLEASLRLLSHSAALPPPVTTNEDKSEATRGAL---------SQRPCRPRPNSI-
-------PPNLPEEETRR---IARI--FSSQFSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELAANSS-RSTTP---RGKDHVCFAEN
PDTIKDSSFGLQHSLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNRFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQ
LPVQQENG---QSPFGPLKVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPS-TFVATP
ASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQK------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEVISCHQKSPASTQVPCSSTTAEVRLT-Q--EGPADLDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDTYAAFSSH
MARQTLDQLAHASSKELDFSSP-----GR---SDTTRSQASRHEEHVQNIRRFHESLHLQ
GEAPLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFRQKLTKPFLPLSPQTQTAI
SQHQESCRDHLGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQDTEALQERCTMPD--EPLVRAPDKGTDSPSPPPLE
ETSNG-GRMLHESLRHAVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSVISDTS-EVISPQPDEVQREGPSCPSPGPFCR-
EELMVKSSFLSSPERAV-----------NPHLPRQGSPSQSLVACECEASKARVGGESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QTDQNKEPKSEAPAENEA------ATS---
-------------ELGDS-------------ADSF-KKL--PLNLASQSRRENHKGPPID
------------------------SSDIRQRQVTTGSET-STKQSL---LLPGPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PLNLPEEETLR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRRDQEPGGGRGRKKR-
----GLSDILPSTSLPPLVEGQLRCFLKLTINKVIWKITKPP-TCVLVRVRWWGETSNGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
IAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYSPLPHTDKTQNVHLSEQ
GYRTNIESSNTQFLIPSKS---HGIPTIKIDGKEA-ANSS-RPSTP---RGKDHLYFAEH
SDTIKDSFFELQHHLNSRQSLE-----SIPLKAKAP-PKHISLLNSTEYQPQIRMAAKSH
SDSCVLSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDAIML-LDKVHPPV-KEDSL
TSSA------------Q-NHDTK------------------------T----DSRAIQLL
LGSAELSKDHCWNGLGSPPDSPSPGSDVYCSSEPNDPQYDQSLLENLFYTA-HKSDNSIS
DFLSEDEDVVPAKKMNQSKALGRSSKVLEPNNHKLMKR--------AASRKNKNL-----
AEQQLLSEAPEDAQIMTLGVDRLALLGRTHSVRIIIETMGVPIDSPEM-TPGKKISAGKP
PKLTT--------VKKRTFFVEYHFPVGFSKTGLGKTALITEVVRLASSKITDG-MVKFQ
QRSVFPVQFGGSMIQHWWNSNLTFQIYGKKTPQKKPEVIGSALLPLRAVIQSELLSFTDQ
LPVQQENG---QTPFGPLKVTMELVRDNKNFTGVNTKLT-SSTQHTPLGVATSPEKKLQE
SNQDTTR---------TRNPQNLNQIHEENTKKAQNLVLPNPKSPSSVATNSS-AFM--P
ASHNLVNQTNESTKENALLLHVLLMVPDGKDFI

PF00168 // ENSGT00510000048072_0_Domain_1 (994, 1084)

TGES--EPPCNVYLICKFFSTEEVTRS
VIAWSTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-PPSGPRPAHFLDQPS-VASVAMEEDQGNGLMEHHFEFHVEMVKGLVPL-
--QATVWGEADCYVQYYFPFQDSQSSVLRGPEFLENGITVKPCRTATTLCIPDPIFNSEH
HHTLLLPTEVPVQRLLLSAFSAQGLVPGGGIQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLIPRFENRKELRS-QSSGLLDVGI
RYWRSLRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALRFSATVGINASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCNGEACFLAELLEFAEITF-AI
YHENTKSVSDISSIQSCKEYLL-GVVKVPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VLLPEDTGLPHGLE
LMQKIVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLQDLVKVDEE---E---L
ATVTISTPRLWLPIHCMLFAGHNHIHKNTFCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASRRAEVTRGPSLLWYFREERLEIQVWRAYGSDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSCL---SPHIEPTRESPLSMDCSSH
SESEQLPRGN-DEMQLSPPC---GHQKSSASTQVPCNSTTAEVCLA-Q--EAPAGLDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVPIPSCCVSFATA-DEPSPVYTQVVENTDSPIWNFQ
H--QLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLIHFKEERQARRGMETQAS-LIPMYSP---FSFPASDIYAGFPSC
IARHTQDQLTHTSSKDLDFSSP-----G---S--TTRSPASRHEEHMQNIRRFHESLQ-Q
GEVVSTSDNKLTKSPLS-SNTSILTSLRKNLSELDEIQQYFSQKLTKPFLPLSPHTNTAI
FQCQENHRDQSGPGV--S-SLDP---QNQCILEKSSNLVLQISSLISDLQTIT--RNS-Q
AALTSHQAR---SRSQEVTTLPDAQDTEAMQERSTTPD--VPLARAAEEGTNSPPPPALE
ETSNG-GGMLHEPLGHTVPVTRMQS-------------------S---EETEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPDEE-QRGLSSLSPGPSPK-
EKLRGRSTFLSSPKMAV-----------NSLLPRQGAPS--LVACEGGASKVRVG-EPA-
STNPKPSTHLPHSGIQRANTFIGWN-SS--RADQDKKPKPEPQVDSEA------ASS---
-------------ELSDS-------------ADST-EKF--SQHLASQRKRENHKKQ---
------------------------------KQVTTESEV-SARQS----LLPEPIVVPNF
FLPPQQLEASLRMLSLSTAVPPPATADQDKNEATRGAF---------SQRPCRPRPHSL-
-------PPNLPEEETHR---IARI--FSSQYSKTD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGGRGRRKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNKVIWKIAKPP-SCVLVRVRWWGETSDGT
IFCPKDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQIGG
LAQLSPTHQINEFFTIVSPTSKKLGELQVSLALEPLSETYNSYSPLPTTDMTENVLLSEQ
GFRENTEPSNTQFLVPLRP---HSIPAIKIDGKELAANSS-RSTTP---RGKDHLYFAEN
PDTIKDSFFGLQHHLNSGQSLQ-----SITLKDRAP-QKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSHNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETNML-LEKVHSPMKEDSLT
TS-T------------Q-IRT-LSRNQFKDHIEDHLLPPTE-NTFWKHDTKADTRAIQLL
LGSAELSQGHIWDGLGSPPDSPSPGSDVYCSSELNDPQYDKSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSKKMNQSKALTRSSKDLESSDHKLKKR--------TAGKKNRNL-----
VEEQMISEPPEDVQVMTLSVDRLALLGRTHSVRIIIKTMKVPPDSPQM-SPGKKSFAGRP
PKLTT--------AKKRTFFLEYHFPVGFSKSGLGKTALITEAVRLASSKVTDG-VVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSALLPLRAVIQSELLSFSDE
LPVQQEID---QTPFGPLKVTMELVTDNKDSTGVKTKIS-SSTQHSLLCAPKSPEKTLPE
PGQDTTC---------TKNPQNLNQIHEETAKKAQNLVLPNPKSPSPVAPNPS-ALMTMP
ISHNSVNQTNGSTKESALLLHVLLMVPDGKDFITGESEK

PF00168 // ENSGT00510000048072_0_Domain_1 (1000, 1084)

QPSCNIYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNMMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDAQYPVIAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIMTL
QRLKNEEETL-PPFSPRPSHFLDQPS-VASVDMRENQGNGLMEHHFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFLVQDSQSSMLKGPEFSENGITLKPFRTATTLCVPDPTFNSKH
HHSLLLPTEVPVQRLLLSAFSAQGLVPGGGVQFEIWYRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HRKNVGVQTFNLPLTPRIEKRKELRN-QSSGFLDVGL
RYRRSLRTAEGVLATRAVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPTLQFSATVGVNASVTTHL
SFLPKGEQRRTHPVACSFCPEFSHYIE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSVSDIANLQSYKEYLL-GVVKVPTKELLVKR-SGITGWFP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEEGSL-HDLE
LMQKIVGGLELSISFTHPGDRERVLEAAELLGWSFE----NNLKDLVKMDEE---E---P
ATVTISTPRLWLPIHCVLLAGHSHIHKSTYCYLRYKLFDHEAFWTPLKKPKESSNKKQVM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNES-VERPHQTDSWIGSAYVDLARL
GERPARTLTVSGVYPLFGRNASNLSGAALQVHVVLSSL---SPHLERIHD-LDSVDCSSH
SESEQLPRRI-DEVQLSLPC---GHQKSPASTQVPCNSTTAEVCLA-Q--EAPAELDG-S
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DEPSPVFTQVVENTDSPIWNFQ
QQSRLSKELLLDSQQSLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAVSPLENLMHFKEEKQTRRGAENPGS-LNPIYSP---FSFPTSDMYTAFSSH
FARQTADQPAHTSSKDLAFSSP-----G---RSGTTRSQASRHEEHVQNIRRFHESLQ-Q
GEAVLPCDDKLTTSPLS-SRTSILTSLRKNLSELDQIQEYFSQKLAKPFLPLSQT-HTAN
LECQESHRDHPGTEA--S-SLDP---ESQCLLEKSNNLVLQVSSLITDLQTLT--KNS-Q
AAWSSHQAR---SRSHKVTTLPDAQDTEAMQERSTTPD--EPLARAPDKSTNSPPPPALG
ETSDG-EGMLRESLRHTVPITRIQS-------------------N---EDLEADPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFVSDTS-EVISPQPDGVQREGPSCPSPEPFLR-
EELKIRSSFLSSPERTV-----------NPHLPSQGSPGQSLVACEGEASKVRIG-EPA-
SAGPQLIPRLTLSGAQKSNTFVGWS-SP--QVDQDKEPKPEAPAENEA------PSS---
-------------ELSDS-------------AESI-EKL--PLNLASQNRRENHKGPLID
------------------------SSDIKKRQATTESET-STRQRL---LLPEPITVPNF
FLPPQQLEASLRMLSLSAALPPPVTTDQDKSKATRGTL---------SRRPCRPRPISL-
-------PPNLPEEETRR---IARI--FSSQYSKKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSCEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-SRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDDVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGTP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKDFTGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQMAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPQPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRRDQEPGGGRGRKKR-
----GLSDILPSTSLPPLVEGQLRCFLKLTINKVIWKITKPP-TCVLVRVRWWGETSNGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
IAQLSPTHQINGFFTIVSPTSKKLGELQVSLALEPLSETYDSYSPLPHTDKTQNVHLSEQ
GYRTNIESSNTQFLIPSKS---HGIPTIKIDGKEA-ANSS-RPSTP---RGKDHLYFAEH
SDTIKDSFFELQHHLNSRQSLE-----SIPLKAKAP-PKHISLLNSTEYQPQIRMAAKSH
SDSCVLSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPDAIML-LDKVHPPI-DSNPN
SSFL------------N-SKKIF------------------------LLKYLLKSFCFTY
LYSAELSKDHCWNGLGSPPDSPSPGSDVYCSSEPNDPQYDQSLLENLFYTA-HKSDNSIS
DFLSEDEDVVPAKKMNQSKALGRSSKVLEPNNHKLMKR--------AASRKNKNL-----
AEQQLLSEAPEDAQIMTLSVDRLALLGRTHSVRIIIETMGVPIDSPEM-TPGKKISAGKP
PKLTT--------VKKRTFFVEYHFPVGFSKTGLGKTALITEVVRLASSKITDG-MVKFQ
QRSVFPVQFGGSMIQHWWNSNLTFQIYGKKTPQKKPEVIGSALLPLRAVIQSELLSFTDQ
LPVQQENG---QTPFGPLKVTMELVRDNKNFTGVNTKLT-SSTQHTPLGVATSPEKKLQE
SNQDTTR---------TRNPQNLNQIHEENTKKAQNLVLPNPKSPSSVATNSS-AFM--P
ASHNLVNQTNESTKENALLLHVLLMVPDGKDFI

PF00168 // ENSGT00510000048072_0_Domain_1 (994, 1084)

TGES--EPPCNVYLICKFFSTEEVTRS
VIAWSTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMIIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDPKISRLLLDARYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSDQIIAL
QRLKNEEGTL-PPSGPRPAHFLDQPS-VASVAMEEDQGNGLMEHHFEFHVEMVKGLVPL-
--QATVWGEADCYVQYYFPFQDSQSSVLRGPEFLENGITVKPCRTATTLCIPDPIFNSEH
HHTLLLPTEVPVQRLLLSAFSAQGLVPGGGIQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTMQ---HREDVGIQTFNLPLIPRFENRKELRS-QSSGLLDVGI
RYWRSLRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVHIIRACGLQAAAKALAEQEPALRFSATVGINASVTAHL
SFLPKGEQRQTRPVACSFCPEFSHHIE--FPCNLVTQHCNGEACFLAELLEFAEITF-AI
YHENTKSVSDISSIQSCKEYLL-GVVKVPTKELLVKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1867)

VLLPEDTGLPHGLE
LMQKIVGGLELSVSFTRPGDRERVLEAAELLGWSFE----NNLQDLVKVDEE---E---L
ATVTISTPRLWLPIHCMLFAGHNHIHKNTFCYLRYKLYDHEAFWTPLKKPKESANKNQVM
VTFKASRRAEVTRGPSLLWYFREERLEIQVWRAYGSDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSCL---SPHIEPTRESLLSMDCSSH
SESEQLPRGN-DEMQLSPPC---GHQKSSASTQVPCNSTTAEVCLA-Q--EAPAGLDG-T
FAVSIL

PF00168 // ENSGT00510000048072_0_Domain_3 (1867, 1974)

VERAMHLSLKGSPLTERKVPIPSCCVSFATA-DEPSPVYTQVVENTDSPIWNFQ
H--QLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFICGWYNITDFSG
ECQGQIKVAISPLESLIHFKEERQARRGMETQAS-LIPMYSP---FSFPASDIYAGFPSC
IARHTQDQLTHTSSKDLDFSSP-----G---S--TTRSPASRHEEHMQNIRRFHESLQ-Q
GEVVSTSDNKLTKSPLS-SNTSILTSLRKNLSELDEIQQYFSQKLTKPFLPLSPHTNTAI
FQCQENHRDQSGPGV--S-SLDP---QNQCILEKSSNLVLQISSLISDLQTIT--RNS-Q
AALTSHQAR---SRSQEVTTLPDAQDTEAMQERSTTPD--VPLARAAEEGTNSPPPPALE
ETSNG-GGMLHEPLGHTVPVKRMQS-------------------S---EETEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFMSDTS-EVISPQPDEE-QRGLSSLSPGPSPK-
EKLRGRSTFLSSPKMAV-----------NSLLPRQGAPS--LVACEGGASKVRVG-EPA-
STNPKPSTHLPHSGIQRANTFIGWN-SS--RADQDKKPKPEPQVDSEA------ASS---
-------------ELSDS-------------ADST-EKF--SQHLASQRKRENHKKQ---
------------------------------KQVTTESEV-SARQS----LLPEPIVVPNF
FLPPQQLEASLRMLSLSTAVPPPATADQDKNEATRGAF---------SQRPCRPRPHSL-
-------PPNLPEEETHR---IARI--FSSQYSKTD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRS---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-SRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMLSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGTP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QTLFGPLKVTMELVTDNKVFTGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLDIQMNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VACVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELGG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYK-
EELTVKSSFLSSPERTI-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPEPIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRRKKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDR--------------------------------
------------------------------------------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGPGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTINRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDHLPIGRVQING
LAQLSPTHQINGFFTVVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQ
GFRENTEPSSTQFQVPSRP---RDIHTIKIDGKELGANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHHLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNPPTKDLLSALLEQGNKLRNAMVISAMKSSPETSVL-LDQVHPPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDCPSPGSDVYCSSELNDPQYDQSLLENLFYTV-PKSDTSIS
DFLSEEDDVVPSKKISQSTALARSSKVLESSDHKLKKR--------STGKKNRNL-----
VEQQMPSETPEDTQTMTLSVDRLALLGRTHSVRIIIETMGIPPDNHQM-TPDKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITNG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFQIYAKKTPQKKLMYMHSVN-----------------
--------------ILTIRVTMELVTDNKDITGVNTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTY---------TKNPQNLNQIHEETAKKAQNLVLPTRKSPSPLAPHPS-TFMAMP
ASHNLVIQTNGSTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGLDKLLGLVKLP
LHQFYMSFKDPKISRLLLDAQYPVVAVDRYMPVIDVFSGHQNGSLRVFLAMGSSDQIMAL
QRLKHEEGTL-PPFSPRPAHFLDQPT-VASVAMAEDRGNALMEHCFEIHVEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQM------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLPLTPRIENRRELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAELLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQII
VTFKASKRAEVTRGPSLLWYFREERLEIQVWQAYGNAS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVALSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEEVSCHQKSPASTQVPCSSTTAEVCLT-Q--EGPAELDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMYAAFSSH
MARQTLDQLAHASSKELDFSSP-----G---RSGTTRNQASRHEEHVQNIRRFHESLHLQ
GEALLPCDDKLTTSPLS-SQTSILTSLRKNLSELDQIQRYFSQKLTKSFLPLSPQTQTAI
SQHQESCRDHLEPGA--S-SLDP---GSQCILEKSNNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRNNKATTLPDARDTEALQEQCTMPD--EPLAKAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHTVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSFISDTS-DVISPQPDEVQREGPSCPSPGPFYR-
EELTVKSSFLSSPERAV-----------NSHLPREGSPSQSLVACEGEASKAKISGESA-
SANPQSIPCPTLSGAQQSRTFVGWS-SP--QADQNKEPKSEAPAENEA------ATS---
-------------ELSDS-------------ADSF-KKL--PLNLASQSRREKHKGPPID
------------------------SSDIRQRQVTTGSET-STKHSL---LLPEPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSRYSQKD------------------------
-------------------------------------------------------

------------------------------------------------------------
-----------------------------------------MKQRKGQGSGGSRGRKKR-
----GLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPP-TCVLVRVRWWGETSDGT
LFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQING
LAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDVTENVLLSKQ
GFRENTEPSSTQFQVPSRP---HDIHTIKIDGKELAANSS-RSTTP---RGKDHVYFAEN
PDTIKDSSFGLQHSLNSGQSLE-----SVTLKGRAP-RKQMSLLNSSEFQPQIRTVAKSH
SDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSML-LDQVHLPINEDSLR
AS-T------------Q-IRA-FSRNQFKDHIEDHLLPSTE-NTFWRHDTKADTRAIQLL
LGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTA-PKSDTSIS
DFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKR--------SAGKRNRNL-----
VEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQM-TPGKKSYAGPP
PKVTT--------AKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDG-KVKFQ
QRFVFPVQFGGPMIEHWWNSNLTFKIYVKKTPQKKPEVIGSASLSLRAVIQSELLSFSDQ
LPVQQEND---QSPFGPLKVTMELITDNKDFTGINTKLS-GNTHYTPLCAPTSPNKALPE
LNQDMTC---------TKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPS-TFVATP
ASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESE

PF00168 // ENSGT00510000048072_0_Domain_1 (999, 1084)

KQSPCNVYLNCKLFSTEEVTRS
VIAWGTTQPVFNFSQ---VIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLP
LHQ

ENSGT00510000048072_0_Linker_1_2 (1084, 1400)

FYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMAL
QRLKNEEGTL-PPFSPRPAHFLDQPT-AASVAMAEDRGNGLMEHCFEIHIEMVKGLAPL-
--QATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEH
HHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQK------------
-VAKGTLPL-SRICAMVTTQ---HREDVGIQTFNLLLTPRIENRKELRN-QSSGLLDVGL
RYRRSPRTAEGVLAARTVS

PF00168 // ENSGT00510000048072_0_Domain_2 (1400, 1547)

ISVQIIRACGLQAAAKALAEQEPALQFSATVGVNASVTTHL
SFLPQGEQRRTHPVACSFCPEFSHHVE--FTCNLVTQHCSGEACFLAELLEFAEVIF-AV
YHENTKSASDIISIESCKEYLL-GVVKVPTKELLIKR-SGITGWYP

ENSGT00510000048072_0_Linker_2_3 (1547, 1866)

IILPEDGGLPHGLE
LMQKIVGGLELSVSFTHRGDRERVLEAAEHLGWSFE----NSLKDFVRMDEG---E---P
ATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYGHEAFWTPLKKPKESVNKKQIM
VTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDS-VERPHQTDSWIGSAYVDLARL
GERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSL---SSHLEPTHE-LDSMDCSSH
SESEQLPRRN-DEVQLSPPEVISCHQKSPASTQVPCSSTTAEVCLT-Q--EGPADLDG-T
FAVSI

PF00168 // ENSGT00510000048072_0_Domain_3 (1866, 1974)

LVERAMHLSLKGSPLTERKVSIPSCCVSFATA-DESSPVYTQVVENTDSPIWNFQ
QQSRLSKELLLDPQQTLVFKVWHKG-DEERVIGFASVDLSPLLSGFQFVCGWYNITDFSG
ECQGQIKVAVSPLESLIHFKEERQARRGVETSKS-LIPIYSP---FSFPASDMCAAFSSH
MARQTLDQLAHASSKELDFSSP-----GR-------------------------------
----------------------------KNLSELDQIQRYFSQKLTKPFLPLSPQTQTAI
SQHQESCRDHLGPGA--S-SLDP---GSQCILEKSSNLVLQVSSLITDLQTIT--RDS-Q
AALSSHRAR---SRSNKATTLPDAQDTEALQERCTMPD--EPLARAPDKGTDSPPPPPLE
ETSNG-GRMLHESLRHAVPITRMQS-------------------S---EDTEAGPAYSDE
DYEEDIIEPRTLNEITTVTDKTSPWSSVISDTS-EVISPQPDKVQREGPSCPSPGPFCR-
EELMVKSSFLSSPERAV-----------NPHLPRQGSPSQSLVACECEASKARVGGESA-
SANPQPIPCPTLSGAQQSSTFVGWS-SP--QTDQNKEPKSEAPAENEA------ATS---
-------------ELGDS-------------ADSF-KKL--PLNLASQSRRENHKGPPID
------------------------SSDIRQRQVTTGSET-STKQSL---LLPGPIVVPNF
FLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGAL---------SQRPCRPRPNSL-
-------PPNLPEEETRR---IARI--FSSQYSQKD------------------------
-------------------------------------------------------