ENSGT00510000046835_0 : Linker Region Query Results

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----------TLYKEKLE--KGS-SEKCIEMADGTWLTPRELEVKGGRERSKNWKKSI--
------YCGGLTLSNLIQE---SL-----------------------------E--F-PS
HSLGEC------------------------------------------------------
PENSNECFVCTDGGKLFCCDSCPRSFHRDNSS--LRPLSAQ----WFCTFCIIRMNK---
---EKRSSYNKSCQLES-EALKH--QMCFEQQVKCEYLLMKMYCCRESM----LFAT---
-DPRNF--TAYSKCVREPMWLDLIKKRLSDET-----------------YN---TVEGFV
LDMRLIFNN-----CKKFNKD-NQFGHLGAKMKEKF-------EKDFKEV----------
------FNIMSRSNSVCCFL----------------------------------------
--------------------------------------------------------

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---------------------M---------LVLH---SLLFIYKILHPP-QTSWNLDDC
F------YMVSSFPRMA-----TEEQNVEDRLIYDRIFSHFKRHKVEISCAIRKTFPFLE
RLRDHEFITNKMFEDSQ----ESCR-N-LVPVQR-VVYNVLSELEKNFNLEVLKI-----
--LFSDVHMKEYPDLIPIYKSFINVLP----DK--SYLQESDEE---------GREE---
--GPSSQLRLE-QGWFRT------------------------------------------
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------------------------PE----------------------------------
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---------------------------------------------------L--------
---KQ--SARL-DTMDAGNNSALEKHSRKRR-----------------------------
---------------------------------------RRRGRPRIN------------
----FTLSYRGRGK---RYQV--------------RV------PRIPR-DKN-MNFQPPE
LPVTCGEIKGTLYKEKLE--QGT-SEKCIKSETGRWLTPREFEIEGGRAPSKNWKLSI--
------RCGGFTLKHLIEY---CHSIF-----LSF-------------LQRILK--SHND
TLGDPY------------------------------------------------------
VKNSNICGVCKRGGKLFCCDTCPRSFHENCHIPLVEAERDP----WSCIFCEIKVIQ---
---ERC-PESQPCRRES-EVLMM--QMLPEVQLKCEFLLLKVYCDSKSL----FFAS---
-KPYYS--REGSQGPQRPMWLDKVKKMLTEKM-----------------YP---QVKEFV
GDMRLIFQN-----HKAFYRE-NKFIKLGLQVENNF-------EKNFKNI----------
------FAIQETSKN---------------------------------------------
--------------------------------------------------------

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-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------IQ--
---------------------NVEGQ-MQEQVCPEPIFRFFRENKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--SPLQMNNVN---------DLED---
--RPRLLPYGK--QENSNAC----HEMDDIAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPKASGG--------------DAEDAP
S------LLPGG---GV-SCKLAIQ---------------------IDEGESE-EMPKLL
PYDTE------------V---LE-SNGM---TDAARTYST--APGEKQGEEEGRNSPR--
-----------------------------KRN-------------------QDKEKYQES
PE-GRDKETFDLKTPQV-TNEGE---PENGL-------------------CLLPGEGEEG
S-D-DCSEMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-TFDLKTPQV--------------TN-EG---EPEK--------------------
-------------------K----------------------------------------
-----------------------------LGLLPGEGEEGSDDCSEMCDG-EEPQEASSS
LARR-------------GSVSSELENHPMNEEGESEELASSLLYDNVPGA--------EQ
SANE-------NEKCSC-VMCFSEEVPGSPEAR---------------TESD--------
---QA--CGTM-DTVDIANNSTLGKPKRKR---RKKRGHGWSRMRMRRQKNSQQ------
---------NDNSKADGQLVSSE-KKANVNLKDLSKIRGRKRGKPGTH------------
------F-----------------TQSDRAAQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLQ--QGI-LVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GFLPD--PPRIRYR-----------KKKRILK--SHNN
NSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WNCIFCRMKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGFRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
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--------------RMS-----TEDQNIVDRLIWNRIFDHFQQHKVDISYAIKKTFPFFE
RLHDRKLITDKLFKDSQ----DSCG-N-LVPVQK-VVYNVLSELEKTFNLEVLSE-----
--LFSDFHLQEYPDLIPIYESFKNVVL----EN--SYGQEIAEE---------KRVE---
--GPTGQLSLE-QGNLKEKA-----ET----R----------------------------
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--------------------------------------------------------NKTV
RCKRE------------R------------------------------------------
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----EILSLLEG------------------------------------------------
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---------ISLGREW--M---K------------------G----KY-----------S
KWSTREHQTT--------------------------------------------------
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-----------------------KHIQRERNR----------------------------
------------------------DRDGKRESETKKMSTKLKKRG-RYRG----------
---------------------------------------RVKGK----------------
-------------------APTHADHHNRPPAKKRR----KRRERKHR-DKN-MNFQLSE
LPVTCGELKGTLHKEKLK--QGS-SVKCIQRDNGRWFSPQRFAIKGGYMRSGNWKQSI--
------RCGGHPLKYLIQE---GHICFPMPPQIY--------------------------
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-------------------MFTFMYMKCWRRAFSKALVRHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----GTCR-N-LLPVER-VVYDILSNVQKKFSQDLLKV-----
--IFSKTHLK--------------------------------------------------
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-------------------------------------------------------MAQRG
Q-----------------QRQM---------ASGGSDLNFRMVT-----------EIQ--
---------------------NMEDQNLQEQVFPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVAR-VMYCVLSELEKTFGWSHLEA-----
--LFSRVNLMAYPDLNEVYRSFQIACC----EY--PPRQMNNVS---------GLQD---
--RPRLLLCGK--QENSNAC----HEMCDVALPQEA---LSS------------------
---------------SRRCGPGFSS-ESHERLALPRADGG--------------DAENAP
S------LLPGG---GM-CCEHAIR---------------------VDEGESE-EMPRLL
PYDMP------------F---LI-PSSG--------------VI---DRKEGGKNSPR--
-----------------------------KRN-------------------QDKEKHQER
EF----NRILF-------------------------------------------------
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-----------------------------------LSAEGNDDCSEMCDG-EEPQEASSS
LARCGSGKGGEDFWPWAAELSSELKDHQMNEEEESEELAASPLHEDVPGA--------EQ
LACE-------NEKGSC-VMCFSEEVPGGPEAR---------------TESD--------
---EG--CLRA-V-----------GWGGSV---GKKKGHSWIRVKRRWQKKIQQ------
---------NGNGKANG-QLMSSEEKVNVNLQGPSKIRRRKRGKPRAR------------
------F-----------------TQSNRAPQKRVR----SRASRKHK-EKT-VDFKAPL
LPVTCGEVKGILHKKNLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLMEN---GFLPN--PPRN--R-----------KKKRILK--YHKN
TSVDPC------------------------------------------------------
MRNLDACEVCRDGGELFCCDTCSRVFHEDCHILPVETEKTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPEEQSKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YS---RVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNLKEV----------
------FAIQETNGIN--------------------------------------------
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---------------------M---------AGGGSDLSTRRLNGCVSRVANEMNHLP--
-------AHSQSLQRL-----FTEDQVVDEGLVYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEINMHEYPDLIHVYKSFNNAIQ----DK--LSFQES-------------------
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-------------------------------------DRK--------------EREEKP
D------I----------------------------------------------------
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----------------K-LSLEQEEVPESPEAK---------------KESD--------
---QA--CGKM-DTVDIANNSTLGNPKRKT---SKKKGHGWSRIKRRMQKKIQQ------
---------NDNSKADG-QLVSSEKKANVNLKDLSKIRGRKRGKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-MDFQAPL
LPVTCGGVKGILHKEKLE--QGT-LVKCIQTEDGNWFTPREFEIKGGYARSKNWRLSV--
------RCGGWPLQRLMEE---GS LPN--PPRIYYR-----------NKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WSCIFCR MKES----
-------SGSQQCCQES-EVLER--QMCPEEHMKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFI
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNANS--------------------------------------------
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------------------------------KISHEAFLNHFKQNKVEISNTITELFPFLE
SLRDCSLIMEESYNDSQ----EAHR-N-LIPVGK-VVYNTLCCLEKNFGRSLLQV-----
--LFSRVHLKEYPDLIHVHRIFKNGN----------------------------------
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-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNFRMVTD-----------IQ--
---------------------NAGDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
CLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLTAYPDLNKIYRSFQNVCY----EH--PPLQMNNVI---------ELED---
--RPRLLPYGK--QENSNAG----HEMGDVAVPQEA---LSS------------------
---------------SPKCEPGFSS-ESCEQLALPNADGG--------------DTEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGELD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKKGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGL-------------------CLLPDEGEEG
G-D-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGGDDCSQMCDG-EEPQEASSS
LARC-------------GSVSSELEDHPMNEEGESEELACSLPHDDVSGA--------EQ
AAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKKKK---RKKRGHCWTRVRRRMQKNVQQ------
---------NEHSKADGQVVLNE-KKANVNLKDLSKIRGRKRGKPGTH------------
------F-----------------TQSDKAPQKSVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGI-LVKCIQSEAGNWFTPREFETKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
VKNLDDVMTCRKSYETV--------------------DIAL----WGTLRVRSSSR----
-------GKAQQCCSGNLRSLGE--EMCPHG-NSCNFVQL-VFCQ---------------
-----SMEGRACQALEGPIG-----------T-----------------LP---PVKAFV
RHRPSIFPGTTGPLQGALFLY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
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----------------------------------------------------------MA
S------GGRELSGRTF-----TDVQDTEDP--VQIVFKYFKTNKVRISYAIQKSFPFLE
GLRDRELITNKMYDDYQ----ESCK-H-LVPVQK-VMYDVLNELEKKFDLAVLDA-----
--LFSEVNRAEYPDLIHIYKDFQNMIH----DK--LCLPEGDGE---------EREE---
--RSHTQLRLE-EGTGRNSA----SRS----LTWSL---PEPSA-D--------------
--------------GKNLTENGLPG-CSHEREQINGLQEEATRERKDAPRSHQTDDQTAQ
E------SAPG------ESFEEVPV----------------------DSDISL-EPPSPP
PYDNK------------R---TEQHSQD---IQMKSCSVP-----------------LV-
DIKKEKP-FYS---------------EDEQRTRTR----A--------K-------YQ-A
T---DVIVISSDDSEEL-SDEDN---FPKASTSA---------------LRSQC----EI
RIQ-GLLESNEEK---ETQEATHSY-QIKPKPMNFRDSPTF-----R-SPL-KRERRRIY
VSSE-SSEEEMLPKVTFCT---PERRSGQN-T----------------------------
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-----------------------------------------------MGA--------EL
QETG-------N-KCFC-VMCCSDRVPEGQEAR---------------MESR--------
---QA--SSRR-DAADVGNNSTLGKDIGKKR---TKKGYTCKIKA-LQKRKRKR------
------------------------KDSLRLASHGPDLPGRKRGRNRLL------------
----SSGSNGSLRK---RGWSKGIKIVTSKLLRRVR----KRGPRIPK-ELN-ANFYTPE
LPVTCGDAKATLMREVFK--QGV-WKKSIRSEDGKWYTPKEFEVAGGRASSKNWKISV--
------RCHGWTLRELMEK---GILPD--PPTKWRKK-------------RTLD--SDIH
TFVDPY------------------------------------------------------
PQNSNECEVCHQGGKLYCCDTCSKSFHENCHIPPVEIERDP----WSCIFCKTKAIR---
----KRCRESPKCHQES-EVLMK--RMDNEEKLKCELLLLKVCCSVERN----PFTT---
-QC-HM--QETAGDQQKCLHLDEIKTELNEKK-----------------YV---LVKEFV
QDIRCMFQS-----YKAL--D-ENYVTVARNLEAKF-------EKNFKNI----------
------FGIQERTPNNYLSPGLGPFSH---------------------------------
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-------------------------------------------------------MAQRD
Q-----------------QGQM---------ASGGRDLNFRMVT-----------EIQ--
---------------------NVEGQNLQEQVFPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVAR-VMYCVLSELEKTFGWSHLEA-----
--LFSRVNLMAYPDLNEVYRSFQNACY----EH--PPCQMNNVS---------WLED---
--RPRLLLCGK--QENSNAC----HEMCDVAVPQEA---LSF------------------
---------------SPRCGPGFSS-ESHEQLALPRADGG--------------DAENAP
S------LLPGG---GM-CCEHAIQ---------------------VDEGESE-EMPQLL
PYDAE------------G--------HK--------------TP---GKKEGGKNSPR--
-----------------------------ERN-------------------EDKDKYQER
EI----NKSFDLNTPQI-TNEGE---PEKGL-------------------SLLPGEGEEG
S-D-DCLEMRDGS---QEASS----SLAKFTLCG---------------------LSISC
FSAE-TFAVHIPQI--------------TN-EG---EPEK--------------------
-------------------R----------------------------------------
-----------------------------LGLLRGEEEEGSDDCSEMCVG-EEPQEPSSS
LARCGS-------------VSSELKDHQMNEEEESEELASSLLHEDVPGA--------EQ
LACE-------NEKCSC-VMCFSEEVPGGPEAR---------------MESE--------
---QG--CLRA-M-----------GWGGSV---GKKKGHCWTRVKRRGQKKIQQ------
---------NGNSKADG-QLMFSEKKTNVNLQGPFKIRRRKRGRPRAR------------
------F-----------------TQTNRAPQKRVR----SRVSRKCK-DKT-VDFKAPI
LPVTCGEVKGILHKKNLK--QGI-LVKCIQSEDGNWFTPSEFEIKGGHARSKNWRLSV--
------RCDGWPLRWLME--------------------------------RILK--SHNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHVAPVETEKTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPEEQSKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YS---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNLKEV----------
------FAIRETNGIN--------------------------------------------
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------------------------------------MFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQEFQEYQ----DRCK-N-LVPVER-VVYDILSDVQKKFSWDLLKV-----
--IFSKTHLKAYPDLKETLKHFFLNEK----QHPRAEVHHDSSL---------EK-----
-----------------ASY-----TF----TKY--------------------------
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---------------M----------ITVTRALEEALLQHFIYKKVEIAYAICKPFPFFE
SLRDKSFITNRMYNESL----EACS-N-LVPVSR-VVHNILTKLEKTFSVSLLMT-----
--LFSQINLHEYPNLEMILQSFKDETLVGA-----IYGKSSRAT---------P------
-----ILLEVP-TGSAQGC---------SLQMLP------PPPPSHPPHLPRGREPKASL
-------QQ-----REAPSSSDPA------------------------------------
----------------------MPLPGLIQEGSHAVVTEVNLTSKMNEEEDPQ-ETPSPA
PTTVH------------------VSRDK-----------------------------LTP
KTKHEGD------------------------PQETP-------------------HT-PS
SPVP----VIGD------------------------------------------------
----ESLEPNDLE---ETQKVPTTPSSK--------------------------------
----------------------------------------KGKK-RKR-----------N
TQSSQRKRLKKRS---------------------------SKG--GRGRKGEGGLAKLAP
LYPTWALSEDSTYFIVNTYIISKLFTEGTKCARWWGFLWILCPYESMGQP-GRKMRTSHI
PTHLVPVL----------------------------------------------------
----------------------------WK------------------------------
----------------------------------TSPGHGIKE------KLQVVDEETQR
K---------DDSACN--------SKIMTRAQKAR-AECAPKSRSKV-------------
----------------KYN-RSDLCPHAEA--HASL---FSHHRKKPQ-DDT-MDFPHP-
IPVTCGKAKGILYLEKIK--LG-TSGKFIQNEEGVWLTPTEFVLEGKERSTNDWKKHV--
------YFRGESLRKL--------------------------------------------
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-----------------------------------------------------MPWESHQ
VEGGCRPRGSSAERPKYFHFPFLEARPSSCVAKQRLPVLPTGISLPFSQSPR-SHPRPAP
GSGSGHEHLAISASRR----------ATMTRALEEALLQHFIHQKLEIAYAINKPFPFFE
VLRDNSFITERLYRESM----EAWE-N-LVPLCR-IVYNILTQLEKTFSLSFLKI-----
--LFSRINLKAYPNLITTLSSFTR---VVT-----SHGGWSRNT---------TIP----
-------LEAP-ANPAGKSS--------SRTLLLPCLPCRYPLRSLPPCAPSVSKPRAPA
-------QHSSEVLREMPSPTGLT------------------------------------
----------------------MALWGTIQEGSLRPVSSDNLI-----------------
-----------------------------------------------------------P
QIKDKED------------------------AQEMP-------------------CT-SS
DPVP----VRRD------------------------------------------------
----DVPEPSDLK---ELQEASRTLPSK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWATSKKRQQKKSHQGSKMRTQEG----AGGQ-----RQLILVRQGAASPGHGIQKTLQG
LDQVTHTEDNPAR---NTKVVTRAQK-RTECAQMPKSEEISDNTSEMDEG-KRPQEPPSA
PPRITLGK----------------------------------------------------
----------------------------EK------------------------------
----------------------------------KRKIHNWSSSKKRQKKCLLKGAA-SS
GLRIQETQKKDDSTRN--------SKVMTRAQKAQ-AEGARKPAQKD-------------
----------------KAG---GGTGHLKAQRGRVS---RGARTEKPK-DET-FDFHSPE
LPVTCGEAKGILYKEKMK--QG-SSEKCIQNEKGVWFTPNEFEIEGKRKRSKNWKRSV--
------FCGGNSLEKLLQK---GILIC--PSSRKHLK---------------T-------
-----------------------------------------------------------E
QENSKECEVCCKGGSLLRCDTCPRFFHEDCHIPPSEAERSP----WSCTFCRIKES----
-------SGNQQGLQES-EVRAR--SMQPEEQLKCEFLLLKAYCHPQSS----FFAE---
-TPCNI--RDYGEPFREAMWLDLVKERLTEKV-----------------YTMAW----FL
RDMRLIFHN-----HKTFFKA-SDFGQVGLDLEAEF-------EKDLKEL----------
------LICHDASENSFQARP---------------------------------------
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---------------------M---------AGGGSDLSTRRLNGGVSRVANEMNHLP--
-------AHSQSLQRM-----FTEDQDVDKGLLYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKIFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFNEVNMQEYPDLIHIRKSFNNAIQ----DK--LFFQES-------------------
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-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
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----------------Q-LSLEQ-EVPESPEAK---------------MEND--------
---QA--CGKM-DTVDIGNNSTLGKPKRKR---KRKKGHSWTRIKSRTQKKIQQ------
---------HDIQQSRWPAESLKEEKAKVNLQGLSKISGRKRSKPGT-------------
----HF------------------THSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGD-FLKCIQTEDGNWFTPAEFETKGGYARSKNWKLSV--
------RCGGWPLQSLMKE---GSLPN--PPKIHYR-----------NKKRILK--SHN-
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHENCHIAPVEPERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPREQLKCEFVLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

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---------------------M---------AGGGGDLSTRRLNECISPVANETNHLP--
-------AHSHDLQRMF-----TEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSDVNMQEYPDLIHIYKGFENVIH----DK--LPLQESEEE---------EREE---
--RSGLQLSLE-QGTGENSF-----RS----LTWPP---SGSPSHA--------------
--------------GTTPPENGLSE-HPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
K------AEPT------ESCEQVAVQ-------------------VNNGDAER-EMPCPL
PCDEE------------SP-EAELHNHG---IQINSCSVR-----------------LV-
DIKKEKP-FSIS--------------KVECQAQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDVDE---PLEVFISA---------------PRSEP----VI
NND-NPLESNDEK---EGQEATCSRPQIVPEPMDFRKLSTF-----RESFK-KRVIGQDH
DFSE-SSEEEAPAEAS--S---GALRSKHG-EK---APMTSRST---------------S
TWRIPSRKR---------------------------------------------------
-------------------------------------RFSSSDFSDLSNG-EELQEACSS
SLRR------------------------------------------GSGS--------QP
QEPE-------NKKCSC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRRHRSKVNG-LQRG----------
---------------------------------------RKKDRPRKH------------
----LTLNNKVQKK---RWQQRGRKAN-TRPLKRRRK---RG-PRIPK-DEN-INFKQSE
LPVTCGEVKGTLYKERFK--QGT-SKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSI--
------RCGGYTLKVLMEN---KFLPE--PPSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGRLFCCDTCPRSFHERCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQSGHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDSKSC----FFAS---
-EPYYN--REGSQGPQKPMWLNKVKRSLNEQM-----------------YT---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFTRLGIQVQDIF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
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---------------M----------FTVTKALEKALLQHFEYKKLDIAYAINKPFPFFE
ALRDNSVITDRLYKESL----EACQ-N-LVPLPK-VVHNVLTSLERTFCPSMLVT-----
--LFSPVNLHEYPRLSAISRSFKN---GNV-----VSPILFTCA---------V------
-----LLH----------------------------------------------------
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--------------------------------------------------------QP-F
S------HGI-FSSRMS-----TEQEN-TEMHLIECMLKHFKTQKVAISNAIRSTFPFLE
SLRDREFITGKMYEDLL----DSCR-S-LVPVDK-VIYRALEELEKKFDMTVLCE-----
--LFNEVNMEKYPNLNLIRRSFECGN----------------------------------
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---------------------M---------AGGGSDLSTRGLNGGVSQVANEMNHLP--
-------AHSQSLQRL-----FTEDQDVDEGLVYDTLFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSE----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHIYKSFKNAIQ----DK--LSFQES-------------------
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-------------------------------------DRK--------------EREESP
D------I----------------------------------------------------
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----------------K-LSLKQGEVPESPEAR---------------KESD--------
---QA--CGKM-DTVDIANNSTLGKPKRKR---RKKKGHGWSRMGTRRQKNSQQ------
---------NDNSKADG-QLVSSEKKANMNLKDLSKIRGRKRGKPGTR------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLE--QGT-LAKCIQTEDGKWFTPMEFEIKGGYARSKNWRLSV--
------RCGEWPLRRLMEE---GSLPN--PPRIYYR-----------NRKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WNCIFCRMKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LVPVER-VVYDVLSNVQKKFSRDLLKV-----
--IFSKTHLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--A-----------GM----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFSLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSGDT---------P------
-----ILIEAP-TGLAEGS---------SLHTPLALPPPQPPQPSSSPCVPRVSEPGTSS
-------QQSDEILCESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
TSTVP------------------VASDN-----------------------------LIP
HIKDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDLE---KPQEVSNTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKKRHKKKN--L---------------------------PRDAASPRHGIQKKLKV
VDQIPQKKDDSTW---NSTIVTRVQKARNECARNSRSEEITDDTSKMNEG-KRSQKTPST
PSRVTQ-------------VA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGRGIKE------KLQVVDKVTGR
I---------DDSIWN--------SKVMTSIQKAR-TECAQKSRSKE-------------
----------------KKKEK-DIC------------------SRKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLGELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCHPRI----NLKRQLNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKRFKENKVEIASAITKPFPFLM
SLRDRGFLSEQKFQV------RSCQ-N-LIPVER-VVYDILSDLQNNFSLALLEV-----
--IFSPTHLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRGLNGGVSRVANEMNHLP--
-------AHSQSLQRL-----FTEDQDVDEGLVYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSE----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHIYESFKNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------K-LSLKQGEVPESPEAR---------------KESD--------
---QA--CGKM-DTVDIANNSILGKPKRKR---RKKKGHGWSRMRMRRQKNSQQ------
---------NDNSKADG-QLVLSEKKANVNLKDLSKIRGRKRGKPGTR------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLE--QGT-LAKCIQTEDGKWFTPMEFEIKGGHARSKNWRLSV--
------RCGGWPLRRLMEE---GS LPN--PPRIYYR-----------KKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVESEKTP----WNCIFCR MKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------LTVTKALEEALLQHFIYQKLDIAYAINKPFPFFE
ALRDNYFITERMYKESL----EACQ-N-LVPLSR-VVHSVLTKLEKTFSLRLLMA-----
--LFSRVNLREYPNLGAVFRSFQK---VGA-----VYGGWGRTT---------P------
-----ILLKAP-ADPAEGS---------SLQTLLPLPPSQPPPSSRPSCASGVNDPKASS
-------QQILELLDEQLHPSDPD------------------------------------
----------------------IPHPGLMQEGRSTPVSSRDHQTE---------------
------------------------------------------------------------
---DKQD------------------------PREMS-------------------HA-PL
GPVP----GNLP------------------------------------------------
-----------------LVLAFPFPGHL--------------------------------
----------------------------------------HTKK-RKR-----------C
IWSTPKRRRQKKHSPQG-----------------------------AASPAHEPQEKLKA
---GTPKEDDSTG---PLKVVRSTQKKRIECARASSSQEISNETSEMNSG-ESKHHAA--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------LVLPEKPE-DDT-ADFLSLT
LPVTCGEAKGILYKEKMK--AG-SSEKCIRNEQGAWLTPKEFLVEGKRAKSKDWKRSM--
------HCGGKTLRHLQEK-----------------------------------------
------------------------------------------------------------
--------------GLLFCPPTVNLKK---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------P-F
S------HGLSAPSRMS-----KVQED-TERMPLEPVFLHFKRFKVAISQAIKRPFHFLA
FLRDTELISDKMYKDFQ----DSCT-N-LVPVEQ-VVYRALEELEKRLDEVVLRV-----
--LFSEENVRAYPDLEDIITNLQNGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGSSDLSSRLNQDILLTVANAVNHIN--
----------SHLQRMP-----TEDQNIDKKVFCEIVFSHFRRYKVEISNAIKKPFPFLE
VLRDRGFISNKMYDDSQ----ESAR-N-LVPVQR-VVYNVLSTLETTFDLSLLEA-----
--LFSEVNMQEYPDLIQIRKSFENAIQ----EK--ICYQESDNE---------EREE---
--RTTTQLSLE-QGTGENSY-----HS----LTWAQ---PDSLNNS--------------
--------------GTTSPENGLSE-HLSEIEQINARRN-TTSGSSDALESQQADERQAQ
E------SESA------ESCEQVPIQ-------------------VNNGDARE-ETASSL
SGAEE------------SPG-AKLPNHE---IKINSCSVL-----------------LR-
DIKKEKP-YFNS--------------KNQQQAEAR----T--------D------CNQ-A
S---DIIVISSEDSAES-SDEDE---PSEAHTGE---------------LRPQP----VF
NDF-GSLESSEAE---ETQEATCSGLHTALATTGVRKSPTC---------R-K---RRSD
DSSE-SSADAVPFRAW--R---SELRSG-P-DK---DPEDIGN----Q-----------S
TWEMSNKKR---------------------------------------------------
-------------------------------------RINDGDYSELNNR-EEHQETSSS
ALRH------------------------------------------ESGA--------EL
QELG-------IEKCSC-VMCFSKGVPRSQEAR---------------TEGS--------
---HA--SDMM-XXXXXXXXXXXXXXXXXXX---XX-XXXXXXXX-XXXX----------
---------------------------------------XKKKRRHGI------------
----QTLNNRLPHK---RGKPRGRKPVNAGPLKRGK----KRGPRIPK-DEN-MDFQPPI
LSVTCGQVKGLLYKDKIK--QGI-SEKCIRMENGTLVTLKEFEIEGNHEKSKNWRLSV--
------RCGGWPLKHLIEN---GFL PD--PPRTRKKT--------------KPK--SRSH
ESNDPY------------------------------------------------------
PENSN TCKVCRKGGTLYCCDTCPSSFHEKCHIQHIDADRSP----WSCIFCQI EGIQ---
----KSSPESQACYQES-EVLER--RM LPKEQLKCEFLLLKIYCCSISS----YFAL---
-KPHYS--TELSRALKKPIWLNKIRKKLIRKL-----------------YS---RVMWFV
RDMRLIFQN-----HKEIYKD-TKFINLGSQLETTF-------ETNFRKI----------
------FAIQTISRNMLVFIL---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------PTLPAAWNEALLQHFTCRKLEIAYAIHKPFPFFE
GLRDKAFITERMYTESL----EACR-N-LVPVSR-VVYNVLTRLEQTFSLQLLEA-----
--LFSQINLREYPRLAAVLRSFRG---ACA-----SHGEWSRPT---------V------
-----VLLEGP-PDPAEGS---------RLQTLLPLPAPPPPPPSCLPTAHRGSEPGGSS
-------ASTS-------------------------------------------------
----------------------ESLPGPTVGGRSTPVTSDSLTSRIDEEEDPQ-ELPSPR
PSPVQ------------G----NVAGDW-----------------------------LRP
TRAIKED------------------------PQLCSL--S------------RAPESPPT
SLPS----IVRD------------------------------------------------
----DSPEPSDPE---EPGEALSPAPNK--------------------------------
----------------------------------------KRSK-RKR-----------S
IWSTPKKRHRKTS---------------------------LP--RETGRASSGIQEKLPV
VDQATHRTDGPTQ---TSGVMTRAQKARAECAQVSRPEEVVFGQGIMNEQ-KRNRKSTHS
FP---EGL----------------------------------------------------
----------------------------GV------------------------------
----------------------------------PSASSGIQE------KLRVVDQATHR
---------TDGPTQT--------SGVMTRAQKAR-AECARVSRPEE-------------
----------------GEP-EARVCSASSSSNQRKR---HREAEKQEA-GDT-VDFHAPK
LPMSCGEAAGILYKEKLG--QG-SWEKCVQNGEGAWFTPSEFAVEGRWGHSKNWKRSI--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------SHGIFSLRMS-----TEEQSVDDSTIYEVIFHHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMYEDSQ----ESCR-N-LVPVQR-VVYNVLCELEKKFNLDLCEA-----
--LFSEVNLQEYPDLIRVRRSFEHGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TGLAEGS---------SLRTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSESRSPSDPV------------------------------------
----------------------LPLSGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
ASTVP------------------VASDN-----------------------------LIS
QIKDKED------------------------PQETP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKRKHKKKSLPRD-----------------------------AASPRHGIQKKLKV
VDQVPQKKDDSTW---NTTVVTRVQKARAECARNSRSEEITDYTSKMNEG-KRSQKTPST
PSRLTKLFTNL-FG----PMA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGHGIKE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSIQKAR-TECAQKSRSKE-------------
----------------KKKE-KDTC------------------SRKPK-SDP-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLAELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRELNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTITRALEEALLQHFINQKLEIAYAIHKPFPFFE
GLRDKSFINEKTYRESL----EACG-N-LVPISK-VVHNILTKLEKTFNLSVLVA-----
--LFSQINLREYPNLRTIFRRFKS---VGA-----SYGEWNRAT---------P------
-----ILFEAP-AGPAEGS---------SLQTLLPQLPPQPLPPSYPRCVPRIREPGASL
-------QQSNEILEEPLSPSDPA------------------------------------
----------------------LPPPGPVQEERRTPVTSDNLTSRINEKEESQ-EIPSSP
PGTMQ------------------VFSDN-----------------------------LTL
QKKDKAE------------------------LQEMP-------------------HT-PS
RPTP----VMRD------------------------------------------------
----DSTESSDPE---EPQEVPSIPPNT--------------------------------
----------------------------------------KGKK-RKR-----------S
IWSTPKKRRQKKSLQRG-----------------------------TASPRHGIQEKIQV
MDQVTQRKDDSTW---NLKVVTRAQKAKIDCTQTSRAKETSDGTSEMNAG-KRSQETSSI
PPRVTQRK----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------NRKNDICSSSKK--KFRK---NTHQKEKPK-DDT-MDFHCSK
LPVTCGEAKGILYKEKFK--KG-SSEKCIQNEKGDWLTPKEFEFEGKGRNTKNWKRNV--
------HCRGKTLSELQKW-----------------------------------------
-----------------------------------------------------------K
--NSEECEVCCREGPLLYCGTCPRVFHEDCHIPPVEAERTP----WSCTFCRMKGF----
-------PGSQQCHQES-EVLER--QMRPEEQLKCEFLLLRAYCHPQST----FFAE---
-IPHNI--WDYGEPFKEAMWLDLIKERLIKEV-----------------YTVAW----FV
RDMRLIFHN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKEV----------
------FGFHEANKNGFRTLI---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MT
S------GGRDLSFRVV-----TGDQSTNEQVSHELIFKHFRKNKVEIATAVTMPFPFLM
SLRDQALISEQMYENFQ----DACT-N-LVPVTR-VVYDVLNELEKTFHPSLLKV-----
--LFSKTNLQAYPNLNKILRSFQNVSH----EYKALLRTNGA-----------DTEE---
--MPRVPSGGG-KGNYGSSY-----QL----PH---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------FFI---------FLVLPNCLSRSLNECISPIANETNHLP--
-------AHSHGLQRMF-----TEDQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFDDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETEEINADRKDTTSDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YRTS--------------NAECRAQ--------------------------A
S---DIIVISSDDSEGF-TDVDE---PLEVFISP---------------VRSKP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPMDSRKSSIF-----REGFR-KRVIGQDC
NFSD-SSEEEALPEVL--S---RALRSKHG-EK---GKNSPLDS---------------R
ALTSEHAQQ---------------------------------------------------
-------------------------------------LSRSHDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGTTHS-CKIRWNGKK---KC-PRIPR-DKN-INFKQPA
LPVTCGDVKGTLYKERFK--QGI-SKKCIQSEDGRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLMEK---EFLPE--PTSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPLVEANKNP----WSCIFCRIKAIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------VHSFWSSRT----IPYSTHWL--STDLPACLKHFKENKVEIASAITKLFPFLM
SLRDRAFISEQMFDHLQ----EACR-N-LVPVNA-VVYTVLSELERTFSLSLLDE-----
--LFSRTNLTAYPDLVEISRSFLNGNKSSQ------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------WGLG-------------------------------------
--------------------------------------------------EGDQRVWG--
-----------------------------KR-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------NHNFVPDT--------EQ
P--A-------QGKCSC-VMCFSRDVPGGSGTG---------------VDSS--------
---QA--QDAT-G---KAAGPWFGRALGGL---RKKKGHNWSRIRRKR------------
------------------------------------------------------------
---------------------------------------------KVR-NQF-VDFCAPL
LPVSCGELKGILFKEKLE--KGI-SIKCILSETGDWLTPREFEIKGGYARSKYWKQSV--
------YCGGRPLLWLMQE---GF LPH--PPRIYHRK----------KK-----------
------------------------------------------------------------
MGNSE VCEVCRRRGLLFCCDTCSRAFHRNCHIPPAKIEETP----WSCIFC RMGSL----
--------DSQESHRES-EILER--QMQPEEQLKCEFLLLKVYCCSESS----IFAK---
-DPRYHRM RETCQSLKEPMWLNKIKRRLNNQG-----------------YS---QVKGFV
QDIRLIFEN-----HRASYKY-RECGQMGIRLETEF-------EKNLKGL----------
------FTIQETNENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTVTRALEEALFQHFICQKLEIAYAIHKPIPFFE
DLRDKFFITERIYKESL----EACQ-N-LVPVSR-AVHNILTQLERTFDLSFLMT-----
--LFSPIDLREYPNLMTVLRSFKR----GN-----EV-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGDNGLSSRMIP----------------
-----------------------ENQNGEQSDDYQLMFKLFKENKVEIASAITKLFPFLM
SLRDRDFISEQKYQECQ----ETCK-N-LVPVDR-VVYDILSDIQKKFSRDLLKV-----
--IFSNVHLKAYPDLQEILKHFLSVSE----NH--RTVQRINGR---------DVEE---
--RPRLPAVVR-EGDYTQAR----VEMKKIKAEKT----PGS------------------
---------------PVSSGGQLND-TCCQEVQGPGFSPQ--------------LRKKEP
K------KKKKSPVSCAASYSPGNT--------------------QMSAGQAE-EVPSLP
QC----------------------------------------------------------
------------------------------------------------------------
------------------N-G-G---DERDF-------------------TCQ---SAEG
R-S-SPEQMCDGQ---EPQDNLPSSLRCEAASCS---------------------PG---
-----------NTQ--------------TN-AE---QAEE--------------------
-------------------A----------------------------------------
-----------------------------PSLPQCNGREGSSSCEQMC-DGPDPQDELSS
------------------------------------------SLRRDTGA---------Q
QPTS-------EERCTC-VMCSPTYVPEDLEAR---------------MGSS--------
---QG--A-----M-DTGRKIPAGKSKKRR---RKKKGYNWSKPKRRKPMIVRR------
---------KYGRRAVTQAVFR--------------------------------------
------------------------RKKMKNPGLSAK----IRGPRRHG-KEM-ANFNAEL
LPVTCGNLKGVLHKDKFK--QGI-SVMSIQCQDGNWVTPPEFEIMGGHGRSKNWKLSL--
------RCYNWPLKLLIQR---NFLPI--PPRIYGKR----------KKKRTQS---LHH
FPADPD------------------------------------------------------
--NSDECEVCRDGGTLFCCDTCSRAFHEECHIPAVEAEVTP----WSCIFCRMQSL----
--------GSQQSLPES-EILQR--EMVPQEQLKCEYVLLRVYCCSESS----FFSK---
-MPYYYYFREMAVGVQEPMWLDIIKRKLSDQA-----------------YS---QVEDFV
QDMRLIFRN-----HRITFKD-PKFGEMGLILESKF-------EKSFKEA----------
------FAIQGRSEKS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGGDLSTRRLNECISPVANETNHLP--
-------AHSQDLQRMF-----TEDQEVDDRLLYDIVFKHFKRHKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKIFNLPVLEA-----
--LFSDVNLQEYPDLIHIYRSFENVIH----DK--LPLQESEGE---------EREE---
--RPGIQLSLE-QGTGENSF-----RS----LTWPP---SGSPSHV--------------
--------------GTTPPENGLSE-HPCETEQINAKRKDTTSDKNDSLGSQQINEQCAQ
K------AEPT------ESCEQVTVQ-------------------VNNGDAGR-ETPCPL
PCDEE------------SP-EAELHNYG---IQINSCSVR-----------------LV-
DIKKEKP-FSNS--------------KVECQTQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDVDE---PLEVFISA---------------PRSEP----VI
NND-SPLGSNEEK---EGQEATCSRPQIVPEPMNFRKLSTF-----RERFK-KRVIGQDY
DFSE-SSEEEAPPEAS--S---GALRSKHG-EK---DPMISRST---------------S
TWRIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSDLSNG-EELQETCSS
SLRS------------------------------------------GSGS--------QP
QEPE-------NEKCSC-VMCFPKAVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRRHRSKVNG-PQRG----------
---------------------------------------RKKDRPRKH------------
----LTWNNKVQKK---RWQPRGRKAN-TRPLKRRRK---RG-PRIPK-DEN-INFKQPE
LPVTCGEVKGTLYKERFK--QGS-SKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSI--
------RCGGYTLKFLMEK---KILPE--PPSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGRLFCCDTCPRSFHERCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQSGHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDSKSS----FFAS---
-EPYYN--REGSQGPQKPMWLNKVKRRLNEQV-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRA-DKFIRLGIQVQDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNITYAINKPFPFFE
ALRDKSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---GNV-----VSPILVTCA---------V------
-----VLQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TGLAEGS---------SLRTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLSGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
ASTVP------------------VASDN-----------------------------LIS
QIKDKED------------------------PQETP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKRKHKKKSLPRD-----------------------------AASPIHGIQKKLKV
VDQVPQKKDDSTW---NTTVVTRVQKARAECARNSRSEGKTDDGICHL---------NGL
VRELTKPFTNL-FG----PMA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGHGIKE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSIQKAR-TECAQKSRSKE-------------
----------------KKKE-KDIC------------------SRKPK-SDP-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLAELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRELNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
M------EGSDGSPRMSTE-----QENTE-MHLIECMLKHFKTQKVAISNAIRSTFPFLE
SLRDHEFITGKMYEDLL----DSCR-S-LVPVDK-VIYRALEELEKKFDMTVLCE-----
--LFNEVNMEKYPDLNLIRRSFGCVFP---NEL---CFQG-------------IDGG---
--NPNSQLSLE-QGPGASYS----QGS----PNGSS---LDLSASE--------------
--------------GWRSNDRRN----------S------NLMQANQTEN-----HQLAE
S------PGHL------DSCELQV-Q-------------------LNNRDATP-ESCSLL
PQNEE--------------R-AVQLNYE---LQINPCFVQ-----------------LV-
DVKKENS-SFSLA--------------GNQQTRARTN------------------QNE--
--DSEIIELSSGD-SDN-GENFS-----EATTTV---------------PSQ--------
-----------------------------PAPAYSRK-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PPTL-RR-DRG-GDTSDTESS
IIIRRRKRTGRKKR-------------------------------ERLGSYL--------
----IRN-IKIPMKPSWKTAFL-ARS----------------------------------
-------------ANPS-------------------------------------------
------------------------------------------------------------
-------------------------------SQRRRK----RGPRIPR-EEN-ADFGGAE
LPVVCGNAQGFLDKEKFK--QGI-YVRSIRGKTGRLFTPMDFEIEGNCEKAKNWRQSI--
------RCKGWTLRELIQK---GVLQD--PPRKKKET-------------P---------
------------------------------------------------------------
------------------------------------------------------------
----------------------R--NPRQTRRQKCELLLLTIYCYPKSG----FFIP---
-KPKQR--KEKFPDLREHMWLNKIKNRLNKKA-----------------YH---SVRRFV
EDMRLIFHN-----HSIFY-K-KRFKNLGIIVGKKF-------EKNFKRI----------
------FSIEDTSEQHEPCNHTVLLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRRLNGVVSRVANEMNYLP--
-------AHSQSLQRI-----FTEDQDVDEGLLYDTIFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEVNMQEYPDLIHIRKSFNNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQEEVPESPEAE---------------MENG--------
---QA--CGKM-DTVGIGNNSTLEKPKRKR---KKKKGHSWTRIKSRTQKKIQQ------
---------HDNSKPGG-QLVPNEEKAKVNLQGLSKISGSKRSKPGT-------------
----CF------------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGS-FLKCIQTEDGNWFTPGEFETKGGYARSKNWKLSV--
------RCGGWPLQRLMKE---GSLPN--PPKIHYR-----------NQKRILK--SHNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMVTD-----------TQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLET-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNAN---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DAEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--GPGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGP-------------------CLPDEGE-EG
S-D-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------A----------------------------------------
-----------------------------LCLLPDEGEEGSDDCSQMCDG-EEPQEASSS
LARC-------------GSVSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKNVQQ------
---------HENSKGNGQVVSNE-KKANVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIRETCQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------SPHHG
P----------------LGNSMS--------CFHIVSFFLRMFTR-----------NQ--
---------------------NPEDQTPEEQVFYEFIFRLFKENKVEIASAINKPFPFLM
GLRDRDFIPEHKYQHFQ----EACR-N-EVPVER-VVYDVLSELEKTFDKTVLDA-----
--LFSNLNLKAYPDLLAICRSFQNG-S---CEN--SLLQANNVR---------ALEE---
--TPSLPPYEG-QGNYHSTY----RMDREEEEPQET---LG-------------------
---------------SPPTCGPSKE-VSCEHKGLQRTNGS--------------NLKEIP
E------LLPGD---GGVSCERVALQ-------------------KDEGGESE-KMPRLL
PYDGE------------G---REHGGKR---ELQGSV-GR----GALRKRKGGGGAQKL-
YIEKKEM-SENSA----------EKKKKETTCDQGANPTS--------NEGELE-ETP-S
L-PAEEKQEHRNAYGET-SDKEE---PQEAL-------------------SSPPACGRVF
VTF-LSSGS------------------C--------------------------------
-------NPEAPQM--------------TG-EE---EPEE--------------------
-------------------V----------------------------------------
-----------------------------PRQLLCDGEEGSSACLEMCDE-EERQEDSSS
SPGS-------------GSVSGELETLRMNREEDSEELTSSLLPNDGQGA--------EL
PAYG-------NEKCSC-VICFSKDVTEGPEAI---------------TASS--------
---QA--CDTM-DTVDLGNNSASGKRKRKR---RKKKGHAWTRVKKRCQRNVHQ------
---------KDRSNTADQLISS-EKRVKIPLQERAKIRGRKRGRP--R------------
----IYL-----------------THNDRALRKRFW----SRGSRKHR-GDS-VNFHSQI
LPVTCGKVKGMLYKKRLK--RGV-LERCIQSEDGQWFTPKEFEVRGGHARSKNWKLSV--
------RCGGRPLRWLMEK---GLL HN--PPRKYFRK----------RKRTIPK--SYNN
TLVDPY------------------------------------------------------
LGNSD VCETCRDGGQLFCCDTCSRSFHEDCHIPPVETERSP----WSCTFCRI KES----
-------SGRQQRHGES-EVLQR--QM QPEEQMKCEFLLLKVYCHSESS----FFSK---
-IPYYYYIREVSQNLKEPMWLDKIKKKLNRQG-----------------YR---QVEGFV
RDMRLIFQN-----HRMSYKY-NDFGLMGLRLEAEF-------ERKFKEV----------
------FAIEETNESS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLS---------------------
-------------TRI-----FAEDQDVDKVLLYDTIFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFSLPVLEA-----
--LFSEVNMQEYPDLIHIRKSFNNAIQ----DK--LSFQEN-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQEEVPESPEAK---------------MEND--------
---QA--CGKM-DTVDIGNNSTLGKPKRKR---KKKKGHSWTRIKSRTQKKIQQ------
---------HDNSKAGG-QLVPNEEKAKVNLQGLSKISGSKRSEPGT-------------
----RF------------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGS-FLKCIQTEDGNWFTPGEFESKGGYARSKNWKLSV--
------RCGGWPLQRLMKE---GSLPN--PPKIHYR-----------NQKRILK--SHNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIRETCQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFI
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FAVSRALEKALLQHFMQQKLEIAYAINKPFPFFE
LLRDKSFISESTYTESL----EACR-N-LVPVCR-VVYNILTKLEKTFNLSLLVT-----
--LFGQINLYEYPSLKKILRSFIN---GNT-----VAETPFAYN---------K------
-----LLR----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLIFTSLSFTF-ISANEINHLP--
---------------------THSQSHKDDGLLYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDREFITDKMFEDSQ----DSCR-N-LVPVQK-VVYNVLSELEKTFNLSVLEA-----
--LFSDVNLQEYPDLIHIYKSFKNAIQ----GI--LCFQ---------------------
------------------------------------------------------------
-----------------------------------GSDGK--------------EKKERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------QL-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------SLKREEVPEGPEAR---------------TESV--------
---QA--CGQM-DTVDIGKKSALGKPKRKR---RKKKGHSWTRIKRTTQKKIQQ------
---------DDNGKADG-QLVSSEKKAKANLQGPPKIRGRKRGKPRAC------------
------F-----------------TQSDRDPQKRVQ----SRASGRHE-DKT-VDFKAPL
LLVTCGEVKGILYKEKLK--QGI-LVKCLQTEDGNWFTPREFEIKGGHARSKNWRLSV--
------RCGGWPLQRLMKE---GF LPN--PPRIYYK-----------NKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDE CELCRDGGELFCCDTCSRVFHEDCHIPPVETEKTP----WSCIFCR MKES----
-------SGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHS-----------------YS---RVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNLKEV----------
------FSIQETNGNR--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------PGR
GTW-----------GM----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TDLAEGS---------SLRTPLALPSPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSELPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEDDSE-EMPSLL
ASTVP------------------VASDD-----------------------------LIS
QIKDKVD------------------------PQETP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKRRHKKKSLPRD-----------------------------AASPRHGIQKKLKV
VDQVPQKKDHSTW---NSTVVTRVQKARAECARNSRSEEITDDTSKMNEG-KRSQKTPST
PSRLTKLFTNL-FG----PMA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGHGIKE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSIQKAR-TECTPSQ-KKK-------------
----------------KKKE-KDIC------------------SRKPK-SDP-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWFTLKEFEMEGKGGNTKNWNRSI--
------RCGGTTLAELRKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRELNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------ISIG-----NQNTDDRRIFETLFRQFKRYKVEISTAIKKTFPFFE
GLRDRELITNKMYEDCQ----DSCR-N-LVPVSS-VVYNVLSQLEKTFDLPLLEA-----
--VFSEVNRQEYPDLNHIYESFVKAIQ---EKI---DHEESDEE---------EREE---
--RPTLPLSLE-QGTWENSC----Q-G----RTWCC---RESSSYD--------------
--------------XXXXXXNALSD-HLGETEQINATRQDTTSDPIDALESQQANEQGAQ
G------SEPA------ESCEQVPIQ-------------------SNSGDARK-ETPSPL
PYEEE------------NPE-ATLPNHG---FQMNSCSVL-----------------LV-
DIKKEKP-FFNPE--------------VEWQTQARTD------------------CNQ--
--APDVIVISSEDSAES-SDGDM---SPEPSTSA---------------LRKAS----VT
NNL-DFLEPSEGG---GAREATCSSQM---------------------------------
--------------------------------S---YPWD---I-ENT-----------S
ICSISNR-----------------------------------------------------
-----------------------------------KRRISSSDTSELSNE-DEPQEMSTS
LLRNG------------------------------------------SX--------XXX
XXX--XX-----XXXXX-XXXXXXXXXXXXXXX---------------XXXX--------
---XX--XXXX-XTTDIGSNSTLGKQSEKTX--XXXXXX--------XXXXXX-------
--------------------------------XXR-----KRGRHRIE------------
----ILSN-RAPKK---RGKPRRRKTINTGPLKRGRK----RGPRIPK-ETN-MDFQLPE
LPVTCGEAKGILYKEKME--KXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
------XXXXXXXXXXXXE---GFLRD--PPRKRKKP-------------ENS-------
------------------------------------------------------------
------------------------------------------------------------
----------NEC-------------------EVCRRKTALFSCNTCSR----FFHE---
-KCHIP--PKDADRNPWSCTFCKIKDLQE-------------------------------
------------------------------------------------------------
-----------RCPESQPCDQQSEVLKKLMLSKEKL------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MA-----TEEQNIEDRLICDRIFTHFKKHKVEISCAIRKTFPFLE
RLRDHEFITEKMFEDSQ----ESCR-N-LVPVQR-VVYNVLNVLEKNFNLEVLKM-----
--LFSNVHMKEYPDLIPIYKSFINVLP----DK--SYLQEISEE---------EREE---
--GPSSQLSLE-QGTGENVF-----QN----LSGPH---SDSSFST--------------
--------------GTTPPESGLLE-HLRETEKANTRRHDMTRYKNDALGGQQANQQCAQ
E------PEPA------G------------------------------------------
---------------------LELCNTG---IQINSCFVR-----------------LV-
DIKKED----------------------EQQAQAG----A--------N------HNQ-A
S---DIIVISSEDSEES-NDGDK---PPRVPLSP---------------LESEPSEE-VI
NVC-DSSKSSETE---EIQEATCSRPKIA--------------------------LGHDL
DFSE-SSEDETPPKIW--S---SAPRSECG-QK---DPVNTRYT---------------S
AWRILKRKLPHRS-----------------------------------------------
------------------------------SSLQCFKWISNSDTSELSHG-EDTLDIRSS
ALRS------------------------------------------GSGA--------EL
QRPE-------KEKCSC-VMCFSSGEPRSQEAT---------------AESS--------
---QT--PDMM-DTTDAGNNSALEKHSRKRR-----------------------------
---------------------------------------RRRGRPRIN------------
----FFLSYRCQRK---RYQLRGRKRANPGPLKRRRV------SRFPR-DES-MNFLLPE
LPVTCGDIKGILYKEKLK--QGT-SERCIKSETGRWFTLREFEVEGDHGPSKNWKLSI--
------RCGGYTLKHLIEN---GHLPN--TPRTRK-------------KQRILK--SHNN
TLRDPC------------------------------------------------------
PENSNICVVCKTWGKLFCCDTCPRSFHENCHIPPVETERDP----WSCIFCKIKVIQ---
---GRC-PESQPHRQES-EVLRM--PMLPEEQLKCEFLLLKVYCDSKSL----FFAS---
-KPYYS--REGSGGPQRSMWLDKVKKTLAEKM-----------------YL---QVKEFV
RDVRLIFQN-----HKVFYRE-NKFITLGHQVENNF-------EKNFKSI----------
------FAIQETSKNNSQLASIMMLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------GTAEIQNTEKQAFGELIFKHFRKNKVEIASAISEPFPFFM
SLRDHDFISEQTFEACQ----EACK-D-RVSVKK-EAYEVLSKLEKTFDPSLLKV-----
--LFSRANLMAYPDLYEVYRSFSD------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANATNHFP--
-------THSHGLQRMF-----TEDQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETAEINADRKDTTSDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPLNHG---IQINSCSVR-----------------LV-
DIKKEKP-YCTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PLEVFISP---------------VRSKP----VV
NND-NSLESNEEK---EGQEATCSRPQTVPEPMDSRKSSIF-----RERFR-KRVIGQDC
NFSD-SSEEEALPEVL--R---RALRSKHG-EK---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RG-TRIPR-DKN-INFKQPA
LPVTCGDVKGTLDKERFK--QGI-SKKCIQSEDKRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLME--------------------------------RILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYSDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQV-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRGLNGGVSQVANEMNHLP--
-------AHSQSLQRL-----FTEDQDVDEGLVYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSE----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHIYKSFKNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------K-LSLKQGEVPESPEAR---------------KESD--------
---QA--CGKM-DTVDIANNSTLGKPKRKR---RKKKGHGWSRMGTRTQKNNQQ------
---------NDNSKADG-QLVSSEKKANMNLKDLSKIRGRKRGKPGTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLE--QGT-LAKCIQTEDGKWFTPMEFEIKGGYARSKNWRLSV--
------RCGGWPLRRLMEE---GS LPN--PPRIYYR-----------NKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVESEKTP----WNCIFCR MKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------PTSPVHGLLE-HLSHTKQTTAKRKCTASDKNDALGRQQANQHCAP
EP--EPEPEPA------VVFRQVGTQ-------------------VDPGDTKR-NEPSLL
SYEEE------------SPT-AELLSHG---FQVNSCSVT-----------------LV-
DIKKEPS--WSPN--------------VAGKAQARIN------------------NNQ--
--LSDVIVISSDSDDEH-----Q---CPKTSSSI---------------PKS--------
-TSVNSSETYAGR---EIQETTCSGPQSTNL----KKPS---------PSWKKRIMDT-P
DSTD-SSENETAEARK------VVLRSDSE-ED---DSMDT-------------------
------------------------------------------------------------
-------------------------------NKYNGRAFSSDDSCKMTLC-EDLPQTSST
GLRRG------------------------------------------SG--------AEY
PGSGN-------ETCSC-VMCFSKGEPRGQEER---------------AESS--------
---QA--SDLMDTRVIEGYSVXXXXXXXXXX--XXXXXX---------------------
------------------------------------------------------------
---------XXXXX---XXXRRKVPHNRDHSQKRDKS----RGPRIPK-DKN-MNFQQPE
LPVTCGKVKGTLYKEKMK--QGT-LAKCILSENGQWLTLREFEVKGERGTWKNWKLSL--
------RCGGWTLKALIEQ---KHL PE--PPSKRKKT-------------TPT---SQKS
TSNDPY------------------------------------------------------
PKNSN TCKVCRGWGKLYCCDTCSNSFHARCHIRRINPKSNP----WSCLLCLL TEAQ---
----QKFPD-KQCHKEA-EVLKR--PMKHVDKLKCEVLLLKIFCYTKSRP---LFIE---
-KPHYI--W----NHRRF MCLNKVKKKLYGNK-----------------YF---QVKMFV
WDMRLITKN-----HKTHYQG-SKFATLDSQLETEF-------EKNFKRI----------
------FDILNKKSHIE-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------STASRALEKALHQHFRYQKLEISYAIHKPFPFFE
GLRDNSFITERTYLESL----EACE-N-LIPVSK-VVYHLLTKLEETFDLSLLVT-----
--LFSQINLQEYPKLTTILRSFRS---VGT-----SCGEGSRAK---------P------
-----VPSTTP-ADPAEGS---------SLQALLPLPPPQPPPPSPPPCARRCE-SEASA
-------QQSKETLAGPRNPSDPA------------------------------------
----------------------PALPGFIPKRRTVPVTDDNLISKINEGDPNN-VFSALL
AHAIQ------------------ISNNN-----------------------------LTL
QMKD-QD------------------------SQEML-------------------HT-PS
PPVP----VVRD------------------------------------------------
----DSPKPNAPE---ESQQAPNTSPNK--------------------------------
----------------------------------------KGKI-SIS-----------C
LESESPHNERKKVLPLD-----------------------------PAA----PQKKAPV
GDQQTQMKEDSTY---NSKIITRSQMARTEHTQTSKAKDINDDTSEMSEA-ASTQETPSG
DAASATMD----------------------------------------------------
----------------------------GA------------------------------
----------------------------------RSRGCNLKD------HLSLLQKIRRK
E---------RGSGEE--------KKVKTTAQGYQ-VFCLREKFFLE-------------
----------------KRTKNCNLSSSKKR--QEKG---LPRVSEKLE-DET-MDFQSPT
LPVTCGEAKGILHKEKMK--KG-ASEKCIQNKKGVWFTPKEFEREGNRAKAKNWKRSI--
------RCRGKTLQHLLKK-----------------------------------------
------------------------------------------------------------
--------------ELLLCPPRINQKRKA---------ETT----WKPVGQKSTRT----
-------SRKTQG---------R--R----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTVSRALEQALLRHFVHQKLEIAYAINKPFPFFE
SLRDKSLIPERMYMESL----EACR-N-LVPISK-VVHNILTKLEKTFNLSLLVT-----
--LFNQINLCEYPNLRTILRSFIN---VGT-----AYGEWSRAT---------P------
-----TPLRVP-ADPEEGS---------SLETLLQLPPPQSPPPRLLFCAHTVHEARASL
-------EQVSESPDQPSGPSAPH------------------------------------
----------------------VPLPGLILGEGSAPEAAP--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------TGHGVQEKPQA
VE---QR-KDPSS---NSKVVSRTQETRAKCAQKSRS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------AVSENPK-ENT-VDFRAPT
LPVSCGKAKGILYRQKME--Q---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------A-------------------------D--
-------GGSGFSTRTS-----TEDQYNDDRLVYETLFKHFKRHKVEISNAIKKPFPFFE
CLRDRELISNKMYDDCQ----DSCR-N-LVPVPR-VAYNVLNELEKTFDLPLLEA-----
--LFSEVNRQEYPNLNHIYKSFEFAIQ----EK--INYQESD------------EEE--V
DNSPHTQLSIE-QGTGENCY-----RS----LTSSC---PQSSSDH--------------
--------------GTAPSENGPLE-NLCEAEQINGNRTDTTSDKNDAQEVQQANEEYAQ
E------SEPA------ESCEQEPIQ-------------------VNNRDTRE-DTPIPL
PCDGK------------S---SPLSNHG---IQVNSCSVH-----------------LV-
DIKKEKP-FFSS--------------TLN----------------------------Q-A
S---DVIVISSD-SEET-SDEDK---APEDSMST---------------LESGPAK----
-----------------------------------RFAEYLESS----------------
-------EDEGPPRAS--C---FVLRSDTD-EE---DPVDIGNK---------------S
LWGIPKRKRYSLDNQGNWKR----------------------------------------
-----------------------------KCVATSGEGISSANYSELSDT-EEPQESSSS
VLRS------------------------------------------GSGA--------EP
QGLG-------SAKCSC-VMCFSEGISRDQGER---------------TESS--------
---QA--SDIM-DTVDIGNNSTSGKHNEKIR---RKRRHIHKKNN-LQKDEV--------
--------------------------------------LVRRRGRHRI------------
----QTLSNRVLWNRGK---QKGRKPVITRSLRRGR----KRGPRIPR-DTR-INFYLLE
LPVTCGEAKGTLYKEKMI--QGT-SEKCIQGVDGRWFTLREFEVEGKYSRSKNWKTSV--
------RCGGFTLKDLIKK---KYLPE--PPRRRRRKQTTPEPS---------------K
DFFDPY------------------------------------------------------
PGNSNICEVCRRPGKLFCCDTCPKSFHETCHIHHIDVNREP----WSCIFCMIKALQ---
----P----SQQCHQIS-EVLQR--RMVPEEQLKCEFVLLKVYCCSKSP----FFAS---
-RPHYS--NNASHGPTKLMWLNKIKKKLNKKL-----------------YL---RVKGFV
QDMCLIFEN-----HRAFYKDNQKFIKLGFQLEDIF-------MNTFGNI----------
------FAIQEIREHSFQLDPTLS------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANETNHLP--
-------AHSHGLQRMF-----TEDQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFDDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETEEINADRKDTTSDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YRTS--------------NAECRAQ--------------------------A
S---DIIVISSDDSEGF-TDVDE---PLEVFISP---------------VRSKP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPMDSRKSSIF-----REGFR-KRVIGQDC
NFSD-SSEEEALPEVL--S---RALRSKHG-EK---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RG-PRIPR-DKN-INFKQPA
LPVTCGDVKGTLYKERFK--QGI-SKKCIQSEDGRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLME--------------------------------RILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPLVEANKNP----WSCIFCRIKAIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
Q------RGQQGQMASG-----DSNLNSQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNENL----SFSAVLCQLVS-----------PNED---
--WRSHEESPVHTDTLRRSC-----I----------------------------------
------------------------------------------------------------
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----------------------------------GR----KRGPRNPR-QHN-VDFSSPE
LPVTCGTAKGILHKKKFE--QGI-HIKSIRSETGGWLTPMKFEIKGDRGGSKNWRQSI--
------RCCGEPLKKLIEE---GKLPN--PPRKRGKK----------QNPP-------NP
RRRTKKK-----------------------------------------------------
PDISKQCKVCGQGRRLHECAMCKKFYHKRCHIPPEEVKSGL----WSCIFCKTKDQL---
----S-YQENQARHKES-EVLRR--KMLPEEQQKCELLLLTIYCHPKSR----FFIS---
-KPKK--RKENFPDIQEHMWLNKIKYRLNRKT-----------------YL---SVQHFV
KDMRLIFWN-----HRIIYNN-CKFSNLGVTVRSLF-------EKTFKRI----------
------FSIEETSN-LQPCTHSVLLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------DSV----EACR-H-LVPVSR-VVYDVLTGLEQTFTPALLGT-----
--LFSHINLREYPRLAAVLRSFRRVCA---SYG--------------------EWRP---
--RPAIALEAP-PGPTEGSC----PQT----LLLPLP-----------------------
---------------QPPPQSQLPS-----------------ASKIGD------------
----------------------LGVS-------------------SPNSSDP--AVPRPV
HILEG--------------R-NTPVT--------NDNLIS-----------------ER-
DEQKDPQKLLSPP--------------F-----------------------------D--
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XXXXXXXXXXXXXXXXXXXXXXXXVVSSGHEMQK---------------KLE--------
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LPVTCGKAKGILYKKKMR--QGS-LEKCIQNGKGAWFTPGEFAADGKKGGKKNWKREI--
------YCGGKALRELLEX---XXXXX--XXXXXXXX-------------XXXX--XXXX
XXXXXX------------------------------------------------------
XXXXXXX----XXXXXXXXXX--X---------XXX------------XX-XXXXXX---
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-------HN-----HKPYM-----------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MLAVIPKKKSFNEIFFDYFKEHKIEIAHAIPKLFPFLE
SLKDRSFITDKIYADSY----EACR-N-LVPVEK-VVYNVLDHLEKLFGWSFLCI-----
--LFNRTNLNAYPGLREIHESLQTELE---DNY---LSQRSKQD-----------QK---
--LVTVQPHYE-QGPNLCTH----------------------------------------
-------------------------------------------------------ENWTG
PC-------FV------K---QENLQ-------------------KPGTK----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--EDEVIVISSEGSECS-DEDDE-----H----------------------R--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------RQMDEE----------
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P-SGA--------QTSCFLTHHY-------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-------------------------MFPISGVLKETLLHHFTCRKLEIAYAINKSFPFFE
SLRDRDLISEKMYRESL----EACG-N-LVPLTR-VVYRILTELEKTFNLSTLQV-----
--LFSQANLSQYPQLMTTFKSFKNVVT---SYG---GW---------------SRPT---
--ATLVEITVD-PAEGQSL-----QMP----LPLPPPQYPV-PSTP--------------
--------------PHVPSEPGAATNH-S-TE-IL-D--QP-PS---------------P
D-------AP-------AD-D-LS-R-------------------I--NQ-EG-S-LP-V
A-DE-L-TS-QI-SE-ES-Q--DM-PE-VP-PI-LA-KX------------------X--
XX-XX-X--XX-X--------------X-X---XX-XX-X-----------XX-X-XX--
---X-XX-X-XX-X--------------XX-X-X----------------XX------X-
X-X-XX-X-X-X----X-X--------------------------------X-X-X-X-X
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IWSTPKRRQRKKYPSRGATSPTHG------------------------------------
---------------------------------LQEKKQVV-DWTTK-------------
------------------------------------------------------------
----R--------KADA--TGESNVKTRTQEAR-----TG-YAQSTGPEXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXADLSGHTTQEKK--QVVEQTTHR---KADSTGES-------
--------------------------------KVRTR--AQKAGTRCAQSARPEXXXXXX
XXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXX----XXXXXXX-XXX-XXXXXXX
PSKNCISVHGAWFTPHKT--EFE-GXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
------XXXXXXXXXXXXX---XXXXX--X------------------------------
--XXXX------------------------------------------------------
X--------------------------------------XX----XXXXXX----XX---
----X--------X--X-XXXXX--XXXX------XXXXXXXXXXXXXX----XXXX---
-XXIDY--SESFQEATWFASVE---ER--LAD-----------------VT---MAAWFV
QDACLICHS-----SKAPYK----------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LVPVER-VVYDILSTVQKKFSRDLLKV-----
--IFSKTHLKAYPDLKETLKHFFLNAV----SLINICLYFKS------------------
------------------------------------------------------------
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---------------R----------FTMTRTLKEVLLQHFIHQKLEIAYAINKPFPFFE
GLRDNFFITERLYQESL----EACR-N-MVPLSR-VVYNILTQLENTFSLSFLET-----
--LFSQINLSEYPNLMTTLKSFKR---VVT-----SNEGWGGIT---------TIP----
-------LEAA-ANPAGRS---------SVRALLLPPTCQHPPSSRPPCSPSVSEPGAPA
-------QPSAEILHEHPSPADLT------------------------------------
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-PIPV------------------VSSDN-----------------------------LIP
QTKDKED------------------------TQEMS-------------------CA-PS
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IWLTSRKRHQK------K---------------------SLP--RGAALPGHGIQTMLHV
AEQVTHREDDSTR---NTKVMTRARKRRTECGQTPAPEEVSDDTSEMDER-KRPQELPST
P--PRLTH----------------------------------------------------
----------------------------XX------------------------------
----------------------------------XXXXXXXXX------XXXXXXXXXXX
XXXXXXXXXXXXXXXX--------XXXXXXXXXXX-XXKGR-------------------
--------------------IKDVCSSATT--SCHR---NSPIKEKPE-DET-LDFHSPK
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------LCRGKTLEQLLE------------------------------------------
------------------------------------------------------------
QENS R ECEVCCRGGPLLCCDTCPRAFHEDCHIPPAEAERST----WSCTFCRM KES----
-------SGSQQCLGES-GVLAR--QM QPEEQLKCEFLLLKAYCHPQSS----FFTE---
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RDIRLIFRN-----HKTFYKV-TD-AQVGLDLEAEF-------EKDLKEV----------
------LVFHEASENSFQVPP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MS-----TEHEN-TEMHPFECMFKHFKTQKVAISNAIRSTFPFLE
SLRDREFITGKMYEDLI----DSCR-S-LVPVDK-VIYKALDELEKKFDVTVLWE-----
--LFNEVNMEKYPDLNPIRRSFECGNW----VL--YRSLRAQ------------------
------SFLLS-TNVY--------------------------------------------
------------------------------------------------------------
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---------------MSTE-----HENTE-MHPFECMFKHFKTQKVAISNAIRSTFPFLE
SLRDREFITGKMYEDLI----DSCR-S-LVPVDK-VIYKALDELEKKFDVTVLWE-----
--LFNEVNMEKYPDLNPIRRSFECVFP---NEL---CFQG-------------IDRG---
--NPNSQLSLE-QGPSASYS----QGS----LNGSS---LDLSSSE--------------
--------------GWRSNDRRN----------S------NLMQANQTEN-----HQLAE
S------PGHL------DSCELQV-Q-------------------LNNGDATP-ESYSLL
PQHEE--------------R-AVQLNNE---FQINPCFVQ-----------------LI-
DVKKENS-SFSLA--------------GNQQTRARTN------------------QNE--
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-----------------------------PAPAYSRT-----------------------
------------------------------------------------------------
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---------------------------------------PPTL-RT-DRR-GDTSDTESS
IIIRRRKRTGRKKR-------------------------------ERLGSYL--------
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LPVVCGNVQGFLNKEKFK--QGI-YSRSIRSETGRLFTPMDFEIEGNCEKAKNWRQSI--
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------RCHNWPLKFLIQR---NFLPN--PPRIYRKR----------KE-----------
------------------------------------------------------------
IQNSDECEVCRDGGTLFCCDTCTRAFHEDCHIPTVEAEMTLSLVKWDLDWSLSLRR----
--------VSR----KC-LLFGK--QMKIVD-----------------------------
------------------------------------------------------------
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------------------------------------------------------------
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---------------------------------------------------------G--
-------KGNGNQLQVS-----TENQNVEERLVFETALRHFKRHKVEISTAIKKTFPFLE
GLRDRELITNKMYEDCQ----DSCT-N-LVPVPK-VVYNVLSKLEKTFNLSLLEA-----
--LFSDVNMQEYPDLNHIRKSFENGN----------------------------------
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---------------MS-----TENQNVEERLVFETALRHFKRHKVEISTAIKKTFPFFE
GLRDRELITNKMYEDCQ----DSCT-N-LVPVPK-VVYNVLSKLEKTFNLSLLEA-----
--LFSDVNMQEYPDLNHIRKSFENAIQ----EK--LSYEE---T---------DGEER-E
ERPA-IQLSLE-QGTSRG-------------LTWSG---GGSSSSD--------------
--------------GTASPENRLSD-YLSETEEINTKSNDTPSNQNDALESQQANEQCDQ
E------SEPA------EFCEPAPIQ-------------------SNDADAGE-ETPNPL
PSNKE------------R---AKASNYG---LQINSCSVH-----------------LV-
DIKKEKP-FFNS--------------EVQLRAQAR----T--------G------YNR-V
S---DIIVISSEDSAES-SDGDE---FPEPSTST---------------PRITVSDH-KL
ESL-K-----------------------------YKFASVFPSEPPG-TLH-EKQQMNDQ
FLCA-EANNLESLGST--C---FYSIEHTK-QS---IPLCIVNI---------------V
FSPHFRK---SSQTIGSTSI----------------------------------------
-----------------------------FRTSSRKRRMSGGDSSDLSNE-GEPQATSSS
ALRD------------------------------------------GSGK--------DL
LNPD-------FEKCSC-VMYSSKSVPRGQEAM---------------TESH--------
---QA--LIGW-DSTDIGSNSTLGKHGGKRS---KTIFYLLKING---------------
---------------------------------------RERGERHRI------------
----EILSNRASKRQTKRMTGKWIETVCTESLKRGR----KRGPRVPR-DTN-MDFQRDQ
LPVACGEVKGILYKEKMK--KGS-SEKCIKDKNGKWFTLKEFEDEGGHRASKNWKQSV--
------RCGGWPLKNLIQE---GF LPN--PSRKRKKKLIVNHSS---------------S
LADPSD------------------------------------------------------
REDSNK CEVCSREKELLSCDTCPRFFHGNCHIPPKLATKNP----WSCIFCQIKDLK---
----KCCPESQPIYQES-EILQK--RMLPREQLKCEFLLLKVYCSPKSS----FFVS---
-EPHYT--RNTSQDLEEPMWLDKIKHKLTMTL-----------------YY---QVWDFV
RDMRLIFQN-----HKVVYRN-NKFINLGRQLEAQF-------ENDFKDI----------
------FGIQEIKLKIFRFF----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------PTLTKAIEETLHQHFVYQKLEIAYAIYKPFPFLE
GFRDNSIITETMYRESM----EAYR-N-KVPIPR-VVYNILTHLEKTFNLSFLEI-----
--LFSQINLYEYPNLKTILKGFKN---AVI-----SYRQRNRTV---------P------
-----TLLEAP-AYPAEGR---------SLQTLLPLLPPQ-H----PPHAPSVSEPSAST
-------QHRAEILGEPSSPSGPA------------------------------------
----------------------VALPRATQERRITPVTNDNLTSQINEDEDSQ-EIPSTP
PDTVQ------------------VSGNN-----------------------------LSS
QTKDKEM------------------------LKEMP-------------------TR-PC
VSRPK---LIRV------------------------------------------------
----DSPEPNDPK---ELQEASSTPPNK--------------------------------
----------------------------------------KGKK-RKR-----------S
IWSTSKKRRQTKSLPKG-----------------------------KASPGPRIQEKLQV
VDQTTQRKGDSTK---KSNLTTRVQKASIECAQTSGPEEISDDYSETNEE-KRPQEPPGT
PLSILH------------------------------------------------------
----------------------------GK------------------------------
----------------------------------ASPEHRIQE------NPQVMDQATER
K---------DDSTRS--------SKVMTRAQKAK-IECVQTLEPKE-------------
----------------KRR-KEDISSSST---RDQK---NIPLKKKSE-DET-VDFLSPK
LPVTCGEAKGILYKEKLK--QG-SSEKCIQNEAGVWFTPKEFEIEGKQANSRKWKQTV--
------RCKGKTLGELIKW-----------------------------------------
-----------------------------------------------------------E
--NFKECEVCCRGGPLLCCDTCPRAFHEDCHIPPAEAERSP----WSCTFCRIE-S----
-------LRRQRCHGES-EAPER--QMQPEEQL---------------------------
-----I--RDYGEPFKEAMWLDLVKERLTEQV-----------------YTVAW----FV
RDMRLIFRN-----HKTFYKA-SDLGRIGLDLEAEF-------EKNLKEV----------
------FIFCKANENSFQTL----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNFRMVTD-----------IQ--
---------------------NAEDQNLQEQVFPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNVI---------ESEE---
--RPRLLPDGK--QENSNAS----HEMGDVAVPQEA---LSS------------------
---------------SPKCEPGFSS-ESCEQLALPNADGG--------------DTEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGELD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTSQI-TNEGE---PEKGL-------------------CLLPDEGEEG
S-D-GCSQTCDGE---EPQEASSSLARC---------------------------GSVPC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGSDGCSQTCDG-EEPQEASSS
LARC-------------GSVSSELEDHPMNEEGESEELACSLPHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDSGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKNIQQ------
---------HENSKADGQVISNE-KKANVNLKGLSKIRGRKRGKPRTH------------
------F-----------------TQSDRAPQKRVQ----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-SVKCIQSEDGNWFTPREFETKGGHARSKNWKLSV--
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TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKQS----
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RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MLAVIPKKKSFNEIFFDYFKEHKIEIAHAIPKLFPFLE
SLKDRSFITDKIYADSY----EACR-N-LVPVEK-VVYNVLDHLEKLFGWSFLCI-----
--LFNRTNLNAYPGLREIHESLQTELE---DNY---LSQRSKQD-----------QK---
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-------------------------------------------------------ENWTG
PC-------FV------K---QENLQ-------------------KPGTK----------
------------------------------------------------------------
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--EDEVIVISSEGSECS-DEDDE-----H----------------------R--------
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------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------RQMDEE----------
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------------------------------------------------------------
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------------------------------------------------------------
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--------------RMITEDQNLEEQHLEEQLCYEFIFMLFKEKKVEIAGAILKPFPFLM
GLRDRGFISEPMYQDFQ----EACR-N-LVPVER-VAYNALDELEKKFDKTVLEA-----
--LFSKVNLKAYPDLLQICNNFQNAIR---DKF---YYQILDEG---------ETKE---
--MLNSQLNHE-QVSLEHSP----LQM----NS------VRGFESM--------------
---------------------------------------PRLLPYNRQENSNAWDEEWPQ
EASSFSPRYVP------VTSDPKAPQ-------------------VPPEGEPK-EVLSLL
PAEGE--------------E-DNN----------ACCVIC-----------------EE-
EEPQE-A-LS-----SPSRCEPVTWDPKAP--QMPPE------------------GEA--
--EEVLSLLPAEGGESC-DPEAS-----QMTDKE---------------EQE--------
-------------------------E-LPSQPLDGEE-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GSGTCLEICDE-EETQESLSS
PPKSG------------------------------------------PGEGG-----TEL
PTFGN--------KCSC-VMCFSKDVPRDPEGR---------------TESM--------
---QA--DDML-DTVDL-------------------------------------------
------------------------------------------------------------
-------------------------------GNNSTV----RKPKKRR-SKSACNFICF-
------------------------------------------------------------
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----NRCPENQPCHQES-EILKR--QM LPEEKLKCEFLLLKVYCWAKST----FFAN---
-EPHYS--RQSSQGPREPMWLNKIKERLKQQH-----------------YH---QVDEFV
QDMRLIFQN-----HKAYYRD-HKFARLGLQLKAIF-------EKNFKDI----------
------FAIQETTKSLISVI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------SLFLRIFTKDQNTEEENTEDQFLYDLLFMLFKKNKVEIASAITKTFPFFM
GLRDRGFLSEQMYENFL----DTCA-N-LVPVER-VVYNVLTELEKTFDLPLLEV-----
--LFSKVNMKAYPDLIEVYQSFQNENV----SFTAVLCQHTS-----------PNSD---
------------------------------------------------------------
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------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNFRMVTD-----------IQ--
---------------------NAGDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
CLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLTAYPDLNKIYRSFQNVCY----EH--PPLQMNNVI---------ELED---
--RPRLLPYGK--QENSNAG----HEMGDVAVPQEA---LSS------------------
---------------SPKCEPGFSS-ESCEQLALPNADGG--------------DTEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGELD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGL-------------------CLLPDEGEEG
G-D-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
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LARC-------------GSVSSELEDHPMNEEGESEELACSLPHDDVSGA--------EQ
AAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKKKK---RKKRGHCWTRVRRRMQKNVQQ------
---------NEHSKADGQVVLNE-KKANVNLKDLSKIRGRKRGKPGTR------------
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LPVTCGGVKGILHKEKLK--QGI-LVKCIQSEAGNWFTPREFETKGGHARSKNWKLSV--
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S-VDP-------------------------------------------------------
------------------------------------------------------------
--------------------------------CKCEFLLLKVYCCSESS----FFAK---
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RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EVSQEVMFKLFRTNKVEIASAITKPFPFLM
SLRDRALISEQMYEDFQ----DACT-N-LVPVRR-VMYDVLTELQKTFHPSLLKV-----
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------------------------------------------------------------
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------------------CL----------------------------------------
------------------------------------------------------------
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--------DCEVPTP---NSEQE---PP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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SGRE-------TEKCFC-VMCCPK-LPEDWAAI---------------TNSS--------
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------------------------------------------------------------
-----------------------------------------KCFRYLK-KTD-VDFSIPE
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RSGKDWL-----------------------------------------------------
WENSEECEVCRDGGTLFCCDSCSRAFHKDCHVARVEANRDP----WSCIFCRVEPF----
--------QVQQRYQES-EILER--PMQAEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYPSEV---SKEHMWLDKIKTKLTKKD-----------------YT---QVEGFV
QDMRLIFEN-----HRHFHKD-PKFGQMGLRLEAEF-------EKNFKEI----------
------FAIQGTNESS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
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-----------NGKVDG-QLVSSKKKANVNLPGPFKIRGRKRGRSRAR------------
------F-----------------TQSDRDPQKRVQ----SRASRRYK-DET-VDFEDPA
LLVTCGEVKGILYKKKLE--RGI-LMKCIQTEDGNWLSLREFAIKGGYARTKNWKLSV--
------RCYGWPLQRLMEE---GF LPN--PPRIYYR-----------NKKRILK--THN-
TSVDPC------------------------------------------------------
MRNVDE CEVCREGGKLFCCDTCSRVFHEDCHIPPVETEKTP----WSCIFCR MKES----
-------SGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYDIREAC QGLKEPMWLDKIKKRLNEHD-----------------YS---RVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLETEF-------EKNLKEV----------
------FAIQETNGIN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MS-----TEQED-TERMPLEPVFLHFKRFKVAISQAIKRPFPFLA
FLRDTELISDKMYKDFQ----DSCT-N-LVPVEQ-VVYRALEELEKRLDEVVLRV-----
--LFSEENVRAYPDLEDIITNLQNGNW----V----------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGDSDLSTRRLNECISPIAVEMNHLP--
-------THSHDLQRVF-----TEDQDVDERLLCDTLFKHFKRYKVEISNAIKKTFPFLE
GLHDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLTHIYKSFENVIQ----DK--LRLQDSEGE---------EREE---
--RPDIQLSLE-QGTGENSF-----RS----LTWTR---SGSPSYD--------------
--------------GTTPPENGLSE-HPCETEQIHAKRKDTTSDKNDALGSQQTNKQYAQ
K------AEPA------ESCEQAAVQ-------------------VNNGDAGR-ETPSPL
PCDEE------------SPG-SELHNRG---VQINSCSVL-----------------LV-
DIKKEKP-FFNS--------------KVERQVKAR----T--------D------HNQ-V
S---DIIVISSEDSEGP-SDIDE---PVEVCISA---------------LRSEP----VV
NND-NPLELSEEE---DDQEATCSRPQIVP------------------------VTGQDQ
DSSE-SSEEETTPKVL--R---RAVRSKHG-EK---DPMTSGSI---------------S
TWRIHNKKR---------------------------------------------------
-------------------------------------RFSSTDFSELSNG-EELQETCSS
PLRS------------------------------------------GSGT--------EL
QEPE-------NEKCTC-VMCFTKGVPRSQEAR---------------PESS--------
---QA--SGMM-DTMDVENNSTLEKHSGKRR---KKRRHMFKANG-LQKG----------
---------------------------------------RKRGRPRKH------------
----STWNNKVLQT---RRHAKGRKAN-TRPLKRRRK---RV-PRIPR-DKN-IDFEQPE
LPVTCGEVNGTLHKERFK--KGT-SKKCIQIEDKRWFTLREFEIEGGREASKNWKLSI--
------RCGGYTLKFLMEK---RRLPE--PPTTRK--------------KRILK--SHNN
TLADPC------------------------------------------------------
PKNSNICTVCNKGGTLFCCDTCPRSFHEHCHIPLVEAKKDP----WSCIFCRMKAIQ---
---ERC-PERQPCHQES-EVLMK--EMLPEEQLKCEFLLLKVYCDSKSP----FFAS---
-KPYYN--REGSRGPQKPMWLNKVKRRLNEQV-----------------YS---RVEEFV
QDMRLIFHN-----HKEFYSE-DKFITLGIQVQDTF-------EKNFKNI----------
------FAIQETSKNIIMLI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------ML----------LTMTKAVEDVLSKHFIQTKVDIAYAINKPFPFFE
ALRDHHFITEEMYKDSQ----EACD-N-LLPVPR-VVYNVLKGLEQTFHPSLLLT-----
------FNLSEYPSLGAVFRSFEN---GKV-----VSSIYFPCA---------V------
-----LRY----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------SLFLRMDKH-----------SQ--
----------------------SIEDSLEEQICPELIFRHFKENKVEIASAITKPFPFLM
SLRDRSFISEQMFENFQ----EACR-N-LVPVAR-VMYDVLSELEKTFDLSLLEA-----
--LFSNVHLKTYPDLNEVFRSFQKGNY----SS--QQLLG---I---------QMDR---
--LPPLRPQGQ-VSESSNTC----PETCDMEEPQEA---LRS------------------
---------------PPSCGP-----VSCEQVALQRTNGE--------------DAKEIP
K------SLPDG---GRESWNPTVQ---------------------KDEEESE-EMPRLI
PYDRE------------E-----------------RGYSI--TEEEKDIETRGRKASG--
-----------------------------KEA-------------------QTTEDLCGS
PFPCFSAETCDSQTPQK-ANERE---PEKEL-------------------SLVADEGEE-
S-T-ACLEACAGE---EPQEALSPLQRL---------------------------GPVSC
G-------PKAPQV--------------TN-EE---EPEE--------------------
-------------------V----------------------------------------
-----------------------------LSQLLCDEEG---NCTLVFPS-TKRIFIFLS
TRRKISP----------SSILICSLSHTQNEEGKSEELTSSPACYDEPGA--------EQ
PGYG-------NEKCPC-VMCFSKDVPGGPEAR---------------TETG--------
---QA--GGTM-DTVDIANNSTSRTPKRKR---KKKKGHSWTRRKGTQQKKIRQ------
---------NGKQAGQAWWLTSVISELWEAEAGGSFTRGRKRRRPRML------------
------L-----------------TQNNRTPQKRVR----SKASRMHG-NET-VDFEAPL
LPVTCGSAKGILHKEKLK--QGS-WVKCIQSKGGHWLTPGEFENKGGHARAKSWKMSV--
------RCGGFPLRKLIED---GFLPN--PPRIHWR-----------RKKA------QNP
QSRNPCP-----------------------------------------------------
LGNLDECEVCRDGGLLFCCDTCSRAFHEDCHIPPAETERTP----WSCIFCRMKEF----
-------SGSQQCHRES-EILER--QMGPEEQLKCEFLLLKVYCCSESS----FFAN---
-IPYYYYIREASQSLKEPMWLNKIKKRLNEQG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-NNFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETKENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKRMYMESL----EACR-N-LIPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVMIYRSFKR---VGA-----SYERQSRDT---------P------
-----ILLEAP-TGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTSVTDDKLTSKMNAEEDSE-EMPSLL
TSTVQ------------------VASDN-----------------------------LIP
QIRDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDPE---EHQEVSSTPSDK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKRRHKKKSLPRG-----------------------------TASSRHGIQKKLKS
VDQVPQKKDDSTC---NSTVETRAQKARTECARKSRSEEITDGTSEMNEG-KRSQKTPST
PRRVT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------ASPGHGIQE------KLQVVDKVTQR
K---------DDSTWN--------SEVMMRVQKAR-TKCARKSRSKE-------------
----------------KKKE-KDICSSSKR--RFQK---NIHRRGKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTPNEFEVEGKGRNAKNWKRNI--
------RCEGTTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCRQGGQLLCCGTCPRVFHEDCHIPPVEAKRML----WSCTFCRMKRS----
-------SGSQQCHHVS-KTLER--QMQPQDQLKCEFLLLKAYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLMFRN-----HKTFYKV-SDFGQVGLDLEAEF-------EKDLKDV----------
------LGFHEANDGGFWTLP---------------------------------------
--------------------------------------------------------

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-----------------------------------------------------MDFRRDQ
LPVTCGEAKGILYKEKMI--KGS-SEKCIKDKNGKWFTLKEFEDEGDHKASKNWKQSV--
------RCGGWPLKILI QF---IL----------------------------EK--APNG
IRKPDP------------------------------------------------------
PEDSNK CEVCSREKALLSCDTCPRFFHGNCHIPPKLATKNP----WSCIFCQ IKDLK---
----KCCPESQPIYQES-EILQK--RMLPREQLKCEFLLLKVYCSPKSS----FFVS---
-EPHYT--RDASQ DLEEPMWLNKIKDKLMMTL-----------------YY---QVWEFV
RDMRLIFQN-----HKMVYRD-SKFIGLGLQLETQF-------ENDFKDI----------
------FGIQEISTN---------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MAD
G-------KKRLETRMSVE-----TRNTDDELIYEIVFNHFKRHKVEISNAIKKPFPFLE
GLRDRELITNKMYEDFQ----DSCR-N-LVPVPR-VVYKVLSELEKIFDLPLLEA-----
--LFSEVNMQEYPDLNQIYKSFENVIQ---EKL---NHEEGDRE---------EREE---
--RPNVQLRLQ-QGSNKNSF----R-S----LTWLS---RRFSSYD--------------
--------------GTSPRENGLSE-HLCEMEQTNAERTDTISDENDALERQQANEHDAQ
E------SEPA------EYYEQVHDE-------------------SDNGDARK-EMPNPE
PTDEK--------------S-AKLSNHG---YQINSCSVY-----------------LV-
DIKKEKP-FLTSE--------------FEFQS-------------------------Q--
--ASDVIVISSEDSAES-GDGEMSS---GASRSA---------------QRTL-------
------------------------------------------------------------
--------------------------------P---DLPN---T-ENK-----------A
FYGPSNR-----------------------------------------------------
-----------------------------------KRRMASSDSSELSDE-GASRKPYTS
FLENG------------------------------------------SG--------KDL
SDSLPLS-----RNGSS-LNCFNKFLEKNSITEKSESRSLHNSTSLSQPRTS--------
---FK--RQFP-DTSDSESNSTLGKHSGKRS--KNA------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------TLFNHFRKSKMEIGDAVTQLFPFLE
SLRDHSFITEKTYNEES----TQARRF-LLNVETIILYHFSIELFKRILRKPLET-----
--LFSKENLKVCPDLTCIQRSFKNGF----------------------------------
------------------------------------------------------------
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---------IPFPSRMS-----TEQED-TENNPFKPIFLHFKRLKVSISTAIKKPFPFLE
FLRDNELITNKMYDDLQ----DSCT-N-LVPLQK-VVYRALEELEKRLDMVVLGL-----
--LFSDENMKAYPDLELILKSFGNG-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMYQKLRIAYAIHKPFPFFE
GLLDNSFITQRMYTESL----EACR-N-LVPVSK-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGEQQSRASCEQQSRDT---------P------
-----ILLEAP-TGLAGGS---------SLRTLLPLPPPQPPQPSCSSCAPRVSEPGTSS
-------QQSDEIPSESPSPSDPT------------------------------------
----------------------LPLPGLIQEGRNTPVTNDKLTPKMNEEEDSK-EMPSLL
ASTVQ------------------VTSDN-----------------------------LIP
QVKDKEG------------------------LQEMP-------------------HS-PL
GPML----EIRD------------------------------------------------
----DGLEPNDPE---EPQEVSSTPSSK--------------------------------
----------------------------------------KGKK-SKR-----------C
IWSTPKKRHKKKSLPRG-----------------------------TASPRHGIEKKLEV
VDRVPQKKDDSTW---KSTVMTRAQKARTQRARKSRSEEISDDTSKMNEG-KRNQETPST
PSRVK-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------TSPGHDIQE------KLQVVDKVTQR
K---------DGSAWN--------SKVMTRVQKAR-KECTQKSRSEE-------------
----------------KKRE-KDICSSSKR--RLQK---NIHRRKKPK-SDT-VDFHWSE
LFVTCGEAKGILYKEKMK--HG-SSTKCIQNEKGAWLTPKEFEIEGKGRDTKNWKRSI--
------CYGGKPLLELLKW-----------------------------------------
-----------------------------------------------------------K
--KSDECEVCCKEGQLLCCGTCPRAFHEDCHIPPVEAKRTP----WSCTFCRMKRS----
-------SGSQQGHHVS-KILER--QMQPPEQLKCEFLLLKAYCHPQSS----FFTA---
-IPLNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLIFHN-----HKTFYKA-SAFGQVGLDLEAEF-------EKDLKDV----------
------FGFHEANDSSFRTPP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------IFKYFRENKVEIASAITKPFPFLM
SLRDRGYISEQKFRNYQ----QSCE-N-QIPPE--IVYDILSDLQNKFSLQLMKV-----
--IFSPTHLKAYPDL---------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------QP-F
S------HGI-FSSRMS-----TEQEN-TEMHLIECMLKHFKTQKVAISNAIRSTFPFLE
SLRDREFITGKMYEDLL----DSCR-S-LVPVDK-VIYRALEELEKKFDMTVLCE-----
--LFNEVNMEKYPNLNLIRRSFECGI----------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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----------------------------MTRALEEALLQHFIYQKLETAYAIYKPFPFLE
SFRDKSFITETMYRESL----EACR-N-QVPVPR-VVYNILTHLEKTFSPSILET-----
--LFSRINLSEYPNLTTILKGFRS---DTFLSYLFYNSHWGFL-----------------
---------------APGP---------EVSIPL----LSIPLLNKDRCAPGGEERELKT
EKDQRSNAQIKHINRKGPQTEDAG------------------------------------
----------------------LSLNPVHQ---------HSI------------------
------------------------------------------------------------
-----ES------------------------GYEGK-------------------HA-PA
T-----------------------------------------------------------
-----------------PEACS-RSPEK--------------------------------
----------------------------------------KNWV-RQSNFDIKIETKYVT
LVLDKKSDSKISLFGPG-----------------------------KASPRQRNQEKLQV
VEQATQRKDDSPR---KSNVMPSAQKASAESAQSSGPEALLCSPSTEADR-PSS------
--RIILRKGR--------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KK
E---------RKKERK--------KEIIY----FF-FNIKKFPHYKR-------------
----------------KRTEKYNLPSSKRR--QERK-----LPRKKPE-DET-VDFLSPE
LPVTCGEAKGILYKEKLK--QG-SSEKCIRNEEGVWFTPKEFEIEGKRAHTKKWKETI--
------YCRGKTLGELLEK-----------------------------------------
------------------------------------------------------------
--------------GL LLCPPRSVKREVK-------------------------------
-------------------------SREKTPRNK CEFLLLKAYCHPQSS----FFAE---
-TPHNI--RDYGEPFKEAMWLDLIKERLNENV-----------------YTVAW----FV
RDVRLIFSN-----HKTFYKA-SNFGQIGLDLEAEF-------EKNLKEV----------
------FIFCKANENSFQTR----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MAD
G-------GSDLSTRVSAE-----DQSIDDRLIYETVFKHFKRHKVEISNAIKKTFPFLE
CLRDRELITNKMYEDCQ----DSCR-N-LVPVQR-VVYNVLNELEKTFDLPLLEA-----
--LFSDVNMQEYPDLDHIYKSFENAIQ---EKL---SYQESDGE---------EAVN---
--SPNIQLSLE-QGTGENSY----R-S----LTWSC---PQSSSYN--------------
--------------GTTPPENGLLE-NLCETEQINANRKDTTSDKNDALESQEANKECVQ
E------SEPA------ESCEQAPIH-------------------VNNGDTRE-ETPSTL
PCDKE--------------R-VELPGHG---IQINSCSVY-----------------LV-
DIKKEKP-FFNLT--------------VDQQAQAKTN------------------CNQ--
--ASDIIVISSD-SAES-SDGDE---PPEASTSA---------------LENGP----VT
NNL-DSLESRKRK---ESQEAACSPLHIT------------------------MVKKF-D
DSSE-STEEEEP--PGVLS---SALRSDPD-EE---DPAD---I-GNK-----------S
IWGINNR-----------------------------------------------------
-----------------------------------KRRISSGDFSELSHT-EEPQESSSS
DLRSG------------------------------------------SG--------AEP
QGL--GN-----KKCSC-VMCFSK------------------------------------
------------DTMDIGNSSTSGKHNEKIR--ATEKKKRAH---R--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNITYAINKPFPFFE
ALRDKSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---GNV-----VSPILVTCA---------V------
-----VLQ----------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANETNHLP--
-------AHSHGLQRMF-----TEDQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFDDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETEEINADRKDTTSDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YCTS--------------TAECRAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PLEVFISP---------------VRSKP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPESMDSRKSSIF-----REKFR-KRVIGQDC
NFSD-SSEEEALPEVL--S---RALRSKHG-EK---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RQQPRGRKTN-NRPLKRRRK---RG-PRIPR-DKN-INFKQPA
LPVTCGDVKGTLYKERFK--QGI-SKKCIQSEDGRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLME--------------------------------RILE--SHNN
TLIDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEANKNP----WSCIFCRIKAIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQV-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------VAEKM---------ASTGTPISGRMITG-----------DQ--
---------------------NPEEQNPEEQFFYEFIFRLFKENKVEIATAITKPFPFFM
GLRDRGFIPEQMYEHFQ----EACT-N-LVPVDR-VVYDALSELEKKFDKTILDA-----
--LFSRVNLKTYPDLLHVCRNFQNV-S---LEQ--SPLQMNNVI---------RLED---
--VPSLLPYNK-QXXXXXXX----XXXXXXXXX-XX---XXX------------------
---------------XXXXXXXFSL-VSCEPKALQGTNEG--------------NSEEIP
K------LQAGN---GGXXXXXXXXX-------------------XXXXXXXX-XXXXX-
--XXX------------X---XLEKN-----SMRD---GE----KTE--------SSAS-
E-----------------------KEEGEK---AGGN--R--------HGKRNQDKYQEI
P-IARYRVTCYPKTPQM-THEGE---PKEVL-------------------CLLPVEGEV-
-SC-FSLVS------------------C--------------------------------
-------DPEASQM--------------TN-KE---EPEK--------------------
-------------------L----------------------------------------
-----------------------------PSQPLCDGEEGSSTCSEVCDE-EEPQESLSS
LPKS-------------GAVSGKLEALQMNTEGDSEELTSSPPSYNGQGA--------EP
PTFG-------NEKCSC-VICFSKDVPGGPEGS---------------TESK--------
---EA--SDMM-DTVDLGNNSTLGKPKRKR---KKKKGHSWSRVKMKHQRKIPQ------
---------KDNSNAAGQLASS-GKKVKRHLQDPAKIRRRRRGRG--R------------
----LHL-----------------THSDRAPQKKVK----SRGRRKRR-YQK-VDFHSRI
LPVSCGKVKGMLHKKKLK--EGV-WVKCIQSEDGDWFTPREFEIRGGHERSKNWKISV--
------RCGGRPLRWLIEK---RFL HN--PPRKYGRM----------R-KRVPK--SHDS
TLDDLC------------------------------------------------------
LGNSD VCETCRDGGKLFCCDTCSRSFHEDCHIPPVETERDL----WSCTFCRA KEF----
-------SGSQRCLGES-EVLAR--QM QPEEQLKCEFLLLKVYCHSEST----FFAK---
-IPYYYYIKEASKNLKEPMWLDKIKKKLNEQG-----------------YS---YVEGFV
QDMRLIFQN-----HRASYKF-NDFGQMGLRLEAEF-------EKNFKEV----------
------FTIRETNEDSS-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------RMD-----------------
------------TDSQ-----NTDNKDLDELIFPQLLLKHFRENKVEIATAITQPFPFLM
SLRDRAFISQTMFENFQ----EACR-N-LIPVPR-VMYDVLSELERTFDPSLLET-----
--LFSKVNLKAYPDLNEIFRSFQKVWDALICEH--HTLNLKREN---------DDEE---
--EPHIHSFQD--RRDSNAY----PEMHDVEEPQEA---LRS------------------
---------------PPRCGPGK---EGCHFLVSLWFPGR--------------DARETL
K------LLPGG---GG-CWKLTPQ---------------------TDGEESE-EIPRLL
PYDRE------------G---RFQINGR---VDQSMSYQE--ATGMWEGEKRGRNRPV--
-----------------------------KRN-------------------KSRPKVPRE
ADRQQAQKSCNTATPQM-TNE-E---LDKVL-------------------SLLPSEGEEG
G-N-TCLEMCDGK---EPQEASSPPPTC-----G---------------------PENRC
LTAE---DGFARQM--------------TN-EE---EPEE--------------------
-------------------V----------------------------------------
-----------------------------PRQLVLE------------------------
-----------------GEVSGELEDQQTDEEGGSDQHTSRLPCDDEPGA--------EQ
PEDG-------NGKCSC-VMCFTKDVPEDPEAR---------------TATG--------
---QP--RGSR-DTVITGNNSTLGQPRRKR---RRKKGHSWSRIKRRRYKPIQQ------
---------NENDKADGQLVSSK---NNMTHQPLAKLKVRKRRRRRKC------------
------F-----------------TRRDRAPRKRGR----ARASRIPR-DPT-MDFQAPL
LTVTCGEAKGTLHKKKLK--QGYQLYKCLHCEDGRNLSPIAVKVKWEKSLQRKNSMTT--
------RTVAEAVLWIFQG---GMLPH--PSRVYNGR----------KKRRILK--SHDT
NSDDPS------------------------------------------------------
LGNMDECEVCRDGGFLYCCDTCSRAFHEDCHIPPVEIEQNP----WSCIFCSMKEF----
-------PEDQQCYQEF-EILEK--QMGPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYLGEACQGLKEPMWLNKIKKKLHEKG-----------------YP---RVEGFV
QDMRLIFQN-----HRASYKY-NNFGQMGFRLEAEF-------EKNFKEM----------
------FAIQEKDENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------RIFTKDQNTEEENTEDQFLYDLLFMLFKKNKVEIASAITKTFPFFM
GLRDRGFLSEQMYENFL----DTCA-N-LVPVER-VVYDVLTELEKTFDLPLLEV-----
--LFSKVNMKAYPDLIEVYQSFQDGLS---EKL---FGNTETQT---------QSGG---
--AR----SRK-AISCGLVA----VQE----D--------EG------------------
-------------------RESE----------ET----PRLLLPYDGEE--KSSIEYPV
EHSSTLTYLGT------VINNPEAPQ-------------------MTNEGELE-EAPGLL
PCEQE--------------E-SKN----------VCLEKC-----------------DG-
EEPQKAS-IS-----SPRNGSAVAWGFFPKHFEPISR------------------GKG--
--NEEMTVFPRSGSLSY-DPETR-----QMTKEV---------------PEE--------
-------------------------M-PDLLPAEGEE-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GGNACLGMYDG-EEPQGALGS
PSRSE------------------------------------------LGKAG---VGAEL
LALGV---E----KCSC-VMCFSRRVPGAQEAR---------------TESS--------
---QA--SDIM-GKV---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------GLNGGVSQVANEMNHLP--
-------AHSQSLQRL-----FTEDQDVDEGLVYDTLFKHFKRHKLEISNAIKKTFPFLE
GLRDHELITNKMFEDSE----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHIYKSFKNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------K-LSLKQGEVPESPEAR---------------KESD--------
---QA--CGKM-DTVDIANNSTLGKPKRKR---RKKKGHGWSRMGTRRQKNSQQ------
---------NDNSKADG-QLVSSEKKANMNLKDLSKIRGRKRGKPGTR------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLE--QGT-LAKCIQTEDGKWFTPMEFEIKGGYARSKNWRLSV--
------RCGEWPLRRLMEE---GS LPN--PPRIYYR-----------NKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVESEKTP----WNCIFCR MKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------VR----KRGPRIPK-ETN-VNFNIPE
LPVTCGNAKGTLYKEIFK--QGV-WKDSIKGENGSWFSPREFEIKGNHAASKNWKLSV--
------RCHGWTLRELIER---GYLPE--PPSKRKK------------------------
------------------------------------------------------------
PQNSNECEVCAQGGQMYCCDTCPKSYHENCHIPPVETESNP----WSCIFCKTKAIR---
----KRCRESQPCHQES-EVLMK--ELCGEEQLKCELLLLKVYCCVDSA----FFVT---
-EPNY--TKGTFVGQQGCTCLDQIKTRLNEKK-----------------YS---RVKEFV
QDIRFIFQN-----YKAFYGK-Q-FIDV-GTLEGRF-------EKNFKNI----------
------FGVQKDSNYLFP------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSVE-----DQNKEERCLCQLIFRHFQKYKVEISHAIKKTFPFLE
GLRDRGFITQKMFEXXX----XXXX-X-XXXXXX-XXXXXXXXXXXXXXXXXXXX-----
--XXXXXXXXXXXXXXXXXXXXXXXXX---XXX---XXXXXXX------------XX---
--XXXXXXXXX-XXXXXXX-----XXX----XXXXXXXXXXXXXX---------------
--------------XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX-----XXXXXXX
X------XXXX------XXXXXXXXXXXXXXXX---------XXXXXXXXXXX-XXXXXX
XX----------------PE-AQLSRHE---IQMTSCTVH-----------------PV-
DIKKEKPDGV------------------EWGAQARTNRKQ--------------------
--TSDIIVISSEDSVES-DVED---EPSEPSTSA---------------LICEP----VI
TNL-DSSESSQGE---GPREATCSCFQMAPAPKDFRRTPTF-----RKNIR-KRVMEH-D
NSAE-SSEEEGS--W---------------------------------------------
-----------------------------------------EGWSSGPSPGPAEEDPVNT
GN----RPIWEKW---NREK-----------------WIIPDDVSELSDG-ERPQDTFSS
SXXXXXXXXXXXXX-------------------------------XXXXXXX--------
--X-X--------XXXX--XXXXXXXXXXXXXX---------------XXXX--------
---XX--XXXX--XXXX----XXXXX-XXXX--X-------------XXXXXXX------
--------------------------------XXXXXXXRKGGRPRIP------------
----VLQRLRVPWK---RVHSRGRKRANTAPLRKS-K---TRGQRIPR-DKN-MNFHSPE
LPVTCGEVKGILYKEIFK--QGV-SEKSIQSEDGEWYTPREXXXXXXXXXXXXXXXXX--
------XXXXXXXX--XXX-XEGYLPY--LPGPTKRK-------------LNS----LNN
DFIDPY------------------------------------------------------
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDP----WSCIFCRIKDTQ---
----ERCPEIQLCHQES-EVLKR--QMLLAEQVKCEFLLLKIYXXXXXX----XXXX---
-XXXXX--X---XXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXXXX
XXXXXXXXX-----XXXXXXN-VEYIPLGLQLEEKF-------EEYFRNI----------
------FAIQERSENITLLT----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------ML-----TDAPHAEDL--MASLFQYFKAHKVEISYAIKKTFPFLE
GLRDRELITNKMYKAYQ----DSCRES-LVPVHR-VMYSVLNDLEKIFDMAVLEA-----
--LFSEVNREVYPALMNIYKDFQNGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKRMYMESL----EACR-N-LIPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGA-----SYEWQSRDT---------P------
-----ILLEAP-TGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPALIQEGRSTSVTNDKLTSKMNAEEDSE-EMPSLL
TSTVQ------------------VASDN-----------------------------LIP
QIRDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDPE---EPQEVSSTPSDK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKRRHKKKSLPGG-----------------------------TASSRHGIQKKLKR
VDQVPQKKDDSTC---NSTVETRAQKARTECARKSRSEEIIDGTSEMNEG-KRSQKTPST
PRRVT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------ASPGHGIQE------KLQVVDKVTQR
K---------DDSTWN--------SEVMMRVQKAR-TKCARKSRLKE-------------
----------------KKKE-KDICSSSKR--RFQK---NIHRRGKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNI--
------RCEGMTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRML----WSCTFCRMKRS----
-------SGSQQCHHVS-KTLER--QMQPQDQLKCEFLLLKAYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLMFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKDV----------
------LGFHEANDGGFWTLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLSRALEKALLQHFILYKLEIAYAINKPFPFFE
SLRDKSFITEGMYRESL----EACR-N-LVPISR-VVYNILTKLEKTFNLSLLMT-----
--LFGQINLCEYPNLRMILKSFIN---GNA-----VVQIPFAYE---------K------
-----LLH----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MTRALEEALLQHFIHQKLEIAYAINKPFPFFE
GLRDNSFITERLYRESM----EAWE-N-LVPLCR-VVYNILTQLEKTFSLSFLKI-----
--LFSRINLKAYPNLITALSSFTR---VVT-----SHGGWSRNT---------TIP----
-------LEAP-ANPAGKSS--------SRTLLLPCLPCRYPLRSLPPCAPSVSKPRAPA
-------QHSSEVLREMPSPTDLT------------------------------------
----------------------VALRGTIQEGRLRPVSSDNLI-----------------
-----------------------------------------------------------P
QIKDKED------------------------AQEMP-------------------CT-SS
DPVP----VRRD------------------------------------------------
----DVPEPSDPK---ELQEASRTLPSK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWATSKKRQQKKSHQGSKMRTQEG----AGGQ-----RQLILVGQGATLPGHGIQKTLQG
LDQVTHTEDNPTR---NTKVVTRAQK-RTECAPMPKSEEISDNTSEMDEG-KRPQEPPSA
PPRITHGK----------------------------------------------------
----------------------------DS------------------------------
----------------------------------MDDDSNL------------SLGK-SP
GKKIQETQKKDDSTRN--------SKVMTRAQKAQ-AEGARKPAQKD-------------
----------------KAG---GGTGHLKAQRGRVS---RGARTEKPK-DET-FDFHSPE
LPVTCGEAKGILYKEKMK--QG-SSEKCIQNEKGVWFTPNEFEIEGKRKRSKNWKRSV--
------FCGGNSLEKLLQK---GILIC--PSSRKHLK---------------T-------
-----------------------------------------------------------E
QENSKECEVCCKGGSLLRCDTCPRFFHEDCHIPPSEAERSP----WSCTFCRIKES----
-------SGNQQGLQES-EVRAR--SMQPEEQLKCEFLLLKAYCHPQSS----FFAE---
-TPCNI--RDYGEPFREAMWLDLVKERLTEKV-----------------YTMAW----FL
RDMRLIFHN-----HKTFFKA-SDLGQVGLDLEAEF-------EKGLKEL----------
------LICHEASENSFQARP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
---------------------------------------------------------MRS
YLQLCT---VRSMLSLCFHFPFLGKPGPHPEPQSTDFLFCLTYLPALLPGFQ-SHPGRAP
GPGKGKEQMAVSVSRR----------ITMTRPLEEALFQHFIHQKLEIAYAINKPFPFFE
GLRDNNFITDTLYRESL----EACR-N-LVPVSR-VVYNILTKLEKTFSLSFLEM-----
--LFGHINLYEYPSLMAVFKSFKN---VVT-----SHRGWSRSA---------AAP----
-------QEAP-ASTAERS---------SVRPLLPLPACQGPPPSGPSLVPSVSEPAAPV
-------QPSTEILPKPPSPAGLA------------------------------------
----------------------KTPPGIIQEGRLTPVSSDSLILQ---------------
------------------------------------------------------------
-TEDKED------------------------TPEVP-------------------CT-PS
GSAP----AIKD------------------------------------------------
----DSPKPHDPE---ELQEAPRMPPNK--------------------------------
----------------------------------------KGKK-KKR-----------C
IWATPKRRHKKK---------------------------CLP--REGALPDHGIQEKLQG
VDQETQRKDDSTG---NAEVMTTAPKTKPKCARTLKPEETTDDIPEVVEE-KRPQEPPSR
PTRTANK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------GKE-------------------
------------------R-NIYSCSSSK---KRQK---KSLPREKPK-DKT-LDFHSLI
LPVTCGEAKGILYKEKMK--LG-SSEKCIQNEEGVWFTPREFEIEGKQKHKKYWKRSV--
------LCGGKTLEHLIKK---GLLIC--PPKR-SLK---------------R-------
-----------------------------------------------------------K
PENSKECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRP----WSCTFCRMREA----
-------SGSQRCLRGS-EGLAR--QMLPEEQLKCEFLLLKAYCHPQSS----FFAE---
-TPRNI--QDYGEPFKEAMWLDLVKERLTERV-----------------YTVAW----FL
RDMRLIFRN-----HQMFYKA-SDFGQIGLDLEAEF-------EKDLKKM----------
------FTVHEAR-----------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANVTNHFP--
-------THSHGLQRMF-----TEDQDVDERLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETEEINADRKDTTSDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGNAGR-ETPCPL
PCDEE------------SNYWAEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YCTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PLEVFISP---------------MRSKP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPMDSRKSSIF-----REKFR-KRVIGQDC
NFSD-SSEEEALPEVL--S---RALRSKHG-EK---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RLSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RD-PRIPR-DEN-INFKQPA
LPVTCGDVKGTLYKEQFK--QGI-SKKCIQSEDGRRFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLME--------------------------------RILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEADKNP----WSCIFCRIKTIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYSDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------LA
A------SGTPHPGLIITGDVNLEEQHPEEQRCYEFVFRLFRENKVEIASAIPKPFPFLM
GLRDRGFISESMFENFQ----EACR-N-LVPVES-VMYKALSELEKKFDKTVLEA-----
--LFSKVNLKAYPDLLQICNSFKNVIH---DNF---YYQTIDEG---------ETKE---
--MLNLQLNHE-QVSLEHSS----LQT----NS------VRGFESM--------------
---------------------------------------PRLLPYYRQENSNAWDEEWPQ
EASSFSPRCVL------VTRDPKALQ-------------------VPPEGEPK-KVLSLL
PAEGE--------------E-DNK----------AYCVIH-----------------VE-
EEPQE-A-LS-----SPSRCEPVTCDPKAP--QMPPE------------------GEA--
--EEVLSLLPAEEGVSC-DPEAS-----QMSDKE---------------EQE--------
-------------------------E-LPSQPLDGEE-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GSGTCFEICDE-EETQEFLSS
PPKSG------------------------------------------PE--------TEL
PVFGN--------ECSC-VMCFRKEVRRVPEER---------------IESM--------
---QE--GDNR-DTADL-------------------------------------------
------------------------------------------------------------
-------------------------------GNNSAV----RKPKRRR-SKSACNFICF-
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MFPG-----------DQ--
---------------------NPEDQNSVEQFFSELIFRLFKENKVEIASAITKPFPLLM
GLRDRGFIPEQMYEDFR----EACR-N-LVPVER-VVYDVLSELEKKFDKKVLDA-----
--LFSKVNLKAYPDLIEILRNFQDVTT---AFM---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------DH-Q----------------------------
------------------------------------------------------------
-----------------------------AQPQRNRGRDGSNGCYEICDR-EEPQEALSS
LPRQ-------------GPGKEQ-------------------------------------
-LTR-------DKKCSC-VMCFSKDVPGDLESR---------------VGS---------
--------SQG-HTVDIGNNSSLGKPKRKR---SKKKTHSPASESWR-------------
--------------------------------QPP-------------------------
---------------------------------SAK----SRHLCRNR-DKS-VDFHSQI
LPVTCGLVKGMLYKKKLK--RGA-LVKSIQREDGNWLTPREFEVNGGFARSKNWKLSV--
------RCGGRPLRWLMEK---GFL HN--PERIYGRR----------KKQRWSH--TLES
HEDPGI------------------------------------------------------
LGNSD ICEMCRDGGWLFCCDTCSRSFHEDCHIPPVETQRNP----WSCTFCR MKES----
-------SGSQQCHGEP-EVLVR--QMGPEEQLKCEFLLLTVYC HSESS----FFAK---
-IPYYYYMKEVSEKLKNPMWLDKIKKRLNEQG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-NDFGLMGLRLEAEF-------EKNFKEV----------
------FAIQEANENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FSVTKATEKALLQHFIYQKLEIAYAIHKPFPFFE
ALRDNKFITERVYRESL----EACG-N-LVPISR-VVHNVLTKLEKTFDLPLLMT-----
--LFSQSNLREYPDLMVIFRSFGS---GNV-----L------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------MSIQCQDGNWFTPTEFEIMGGHGRSKNWKLSL--
------RCHNWPLKFLIQR---NFLPN--PPRIYRKR----------KM-----------
------------------------------------------------------------
NQNSDECEVCRVGGTLFCCDTCSRAFHEECHIPTVEAEMTLSLAKWDLVWSPSLRR----
--------VSR----KC-LLFRK--QMKRVD-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSTE-----HENTE-IVPLELMFQHFKRXKVAISKAIRSTFPFLE
SLRDHDFITDKMYEDFL----DSCR-S-LVPVQN-VIYRALDVLEKKFDMTVLHE-----
--LFNNVNMEKYPDLNHIYRRFPCVFP---NEL---CFQG-------------IDGR---
--DPNSQLSLE-QGPTCSCS----QGS----LTGSP---LDLSLSE--------------
--------------DWRSNDRRN----------S------NLMQGNQTEN-----HQLPK
S------PSHL------DSCELQV-Q-------------------LNNGGATL-ESYSLL
PQNEE--------------R-AVQLDCE---FQINPCFVQ-----------------LV-
DIKKENS-SFSLG--------------GNHQTRARTN------------------QNE--
--DSGVIEISSGD-SDD-GEDFS-----EATTIL---------------PSQ--------
-----------------------------PVPAYSRK-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PPTL-RT-DRR-GDTSDSDSS
IIVKGRKRTGRKKR-------------------------------ERLGNYS--------
----IRN-IKIPMKASWKPAVL-ARS----------------------------------
-------------AYPS-------------------------------------------
------------------------------------------------------------
-------------------------------SRRGRK----RGPRIPR-EEN-ADFRETE
LPVICGNVKGFLNKEKFK--QGI-YVRSIQSETGRWLTPMEFEIEGNREKSKNWRQSI--
------RCKGWTLRELIQK---GVLQD--PPRKKKET-------------P---------
------------------------------------------------------------
------------------------------------------------------------
----------------------T--NPRQTKRQKCELLLLTIYCYPKSG----FFIP---
-KPKQR--KEKFPDLQEHMWLNKIKNRLNKKA-----------------YH---SVQRFV
RDMRLIFHN-----HSILY-K-SKFKNLGIIVRNKF-------EENFRRI----------
------FSIEDTSKQREPCTHTVLLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------LVQQSKQWKIP
G------GASDL-----SS-----RMTSEDQNQEDLIFKYFKENKVEIASVIKTPFPFLM
SLRDHSFISQKMFEHYE----KAC--S-LVPVPR-VAYDVLGELEKSFSLSLLET-----
--LFSKANCRSYQGLEEIHKSFLNVSQ---GQL---SRQTNNQKGPVKERASSQFGG---
--QEDSNVCHE-TCDVEVP-----QEA----LSSPPRSGSXXXXXX--------------
--------------XXXX---------------XXXX-----------------------
------------------X-X-XX-X-------------------X--XXXXX-X-XX-X
XXX-----X--XXX-------XXXXXXXX--XXXXXXXXX-----------------XX-
XXXLENT-GI--------------------------------------------------
-------------KSE-----GR---TITAPGWQ---------------ERERE----DG
XXXXXXXXXXXXX---XXXXXXXXXXXX--------------------X--XXXXXXXXX
XXXXXXXXXXXXXX----------XXX------------------XXX------------
---------------XXXX-XXXX----X-------------------------XX----
---------------------------------X-XXXXXXXXXXXX--------X----
X-----------------------------------------------------------
-XXXX--------XXXX--XX-----XXXXXXX-----XXXXXXX--XXXXXXXXXXXXX
XXXXX--XXXXXXNVDNRN-----------------NCTSGK------HKS-RR------
--------------------------------RWAFLDM---------------------
-------------------------------TTIGEN----VYKRKLR-DET-MDFKAPL
LPVTCGEVKGILYKSKLK--RGI-HMQCIKTEDGDWFTLREFEIIGGYERSKNWKLSV--
------RCGGHQLFWLLQE---GFLPH--PPRKYHKS-------------KXXX--XXXX
XXXXXX------------------------------------------------------
XGHSDKCKVCQAGGLQCYCRP-RGASPEDCHILPVEVERPL----WTCIC-GINEF----
-------PESQQRHQEP-EMLER--QMWPKEQLXXXXXXXXXXXXXXXX----XXXX---
-XXXXX--XXXXXXXXXXXXXX---XX--XXX-----------------XX---XX----
--XXXXXXX-----XXXXXXX-XXXXXXXXXXXXCM-------NENFDEV----------
------FTISNRDWCTE-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------ISTE-----DKNAQDRLFYETVFRHFKRHKVEISSAIKKAYPFFE
GLRDRELITNKMYEDAQ----DSCR-N-LVPIQR-VVYHVLSELEKTFDVPLLEA-----
--LFSEVNMQEYPDLQYIYKSFEKAVQ---EKR---YLQEREGE---------QMEE---
--RPNIQLRLE-QGTGENS-----R-S----PSWSG---EESSSYH--------------
--------------GTAPPENGLSE-HLRETEQINTNRKDTTSDKNNELESHQANEQCAR
E------SEPA------ESCEQAPIQ-------------------ENNGDARR-ETPSPA
SCDEE------------RPA-AQLLSHG---IQLNSCSVH-----------------LV-
DIKKE---IFNPG--------------DERQSQTRAN------------------SNQ--
--ASDVIVISSDDSAES-SDGDE---FSEASTWI---------------LKSCP----VI
NNF-DSLESREGG---EIQEATCSRSQLTPELMDLRKLPTC-----RKGPR-KRLMAY-K
DSSE-SRVDEAP--LGARS---SVWRRDPD-EE---DPAD---F-GSK-----------S
ILGISNT-----------------------------------------------------
-----------------------------------KRWIGSDDFSELNNG-EEPQETSIS
ALRSG------------------------------------------SV--------SLL
QEP--GN-----EKCSY-IMCFSKGVPGSQEAR---------------TENN--------
---QP--SDMM-DTMDIGNNSTLGKHSGKRR--KKRRCMNKK---NSLRKGKN-------
--------------------------------KWR-----PMRIMPLH------------
----G-----PIQR---KTQRDRKRMFTTGPLKRGR-----RGPRIPR-DEN-INFRLPE
LPVTCGEVKGILYKEKMK--EGI-SEKCIQSEGQSWFTLREFEVKGNYGPSKNWKLSV--
------RCAGWPLKFLIEK---GFLPN--PPRKRKKV-------------IIR-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQVSL----ETCR-N-LLPVDR-VVYDILSNVQKKFSRDLLKV-----
--IFSKTHLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTGRLNECISPIAIVTNHRP--
-------THSDSLQRMF-----VEDQDIDEGIFCDTVFKHFKRYKVEISNAIKKTFPFLE
GLHDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHIYKSFENVIQ----DK--LRLQDSEGE---------EREE---
--RPDVQLSLE-QGTGENSF-----RS----LTWTR---SGSPSYD--------------
--------------GTTPPENGLSE-HPCETEQIHAKRKDTTSDKNDALGSQQTNKQYAQ
K------AEPA------ESCEQAAVR-------------------VNNGDAGR-ETPSPL
PCHEE------------R---SELRNHG---VQINSCSVR-----------------LV-
DIKKEKP-FFNS--------------KVERQAKAR----T--------D------RNQ-V
S---DIIVISSEDSEGS-TDVDE---PKEVPSSA---------------PRSEP----VV
NND-SPLESSEEE---EDQKATCSRSQTGSDTMDFRKSPIF-----RESCR---KRGQDH
DSSE-SSEEDAIPRIL--S---RALRSKHS-EN---DPMTSGST---------------S
TWRTH-KKR---------------------------------------------------
-------------------------------------RFSSTDFSELSNG-EEPQETCSS
PLRS------------------------------------------GSGT--------EL
QEPE-------NKKCTC-VMCFPKGVKRSQEAR---------------PESS--------
---QA--SGMM-DTMDVENNSTLEKHSGKRR---KKRRHMSKANG-LQKG----------
---------------------------------------RKRGRRRKH------------
----STWNNKALQT---RRHPKGIKAN-TKPLKRRRRRRRRRAPRIPR-DKN-IDFEQPE
LPVTCGKLRGTLHKERFK--QGT-SKKCIQIEDKRWLTPREFEIEGGYEASKNWKLSI--
------RCGGYTLKSLMEQ---RRLPE--PPTTRK-------------KQRILK--SRNN
TLVDPCVSISLQLQPQNGSGISPDTLCHDGLSPKRAQSQLEYVAVCDEQRIPDASPDANQ
VSVLPASGRATR--HVLRFSDFPSSMAPKRQSPLLPQKKKP----RPPPAQGLEETSASA
GLLEKGEKEQQEAIEHI-DDVQNEIDRLNEQASEKILKVEQKYNKFRQP----FFQK---
-RSEWI-------AKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVT---ECEDIK
SGYRIDFYF-----DENPYFK-NKVLSKEFHLSESGDLSSKSPEIKWKSGKDLTKRSNQT
QNKASRKRQHEEPENFFSWFTDHSDAGADKLGEVIKDDIWPNPLQYYLVPDMDDEEGEGE
EEEEEEEDDDDDDDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD

------------------------------------------------------------
------------------------------------------------------------
------------------------------------SLFLRMFTE-----------NQ--
---------------------NLEDQTPEEQAFYEFIFTFFKENKVEIASAINKPFPLLM
GLRDRGFISEQKYENYE----EACS-N-RVPVQN-VVYRVLCELEKTFDKTVLDA-----
--LFSNTNLKAYPDLLEICRSFQNE-S---SEH--SLPQMNNVR---------ALEE---
--TSSLLPNEK-IENKERQK----ELAGLGLTMWEA---RDL------------------
---------------ERKTEPRFPS-VYCKHKALQRTDGG--------------DFKEMS
E------LLPGN---GIMLPSYTISP-------------------G----RRN-K-----
-TTAP------------G---KHDGEKR---EVGTDM-GK----ETNQDKEECQEIPRV-
------------------------K----QRWKQKR--QT--------HVGRVKMRKR-T
K-LLGCGTEHGNAYWET-REEEE---PQEAL-------------------SSPPTCGQDK
GGI-ASPGL------------------Q--------------------------------
-------GI-------------------RQ-KE---RSIS--------------------
-------------------F----------------------------------------
-----------------------------ARKKFLS------------------------
---------------------SQ---------MENHPLVSVIPSEDDNGP---SFVTRHL
PGWER--ALFFSFFLLL-VFCFSLKTHVGGEA------------------AQ--------
---TG--CAQV-EEYHTSETSVLGGTRWHR---RKKKGHAWTRIKRRYQGRVNQ------
---------KERSDTADQLVSS-ERKVKKRLQRSAKIRGKRRGR----------------
------------------------IHSERAPQKRFQ----SRGSRRRR-DDS-VDFHSQI
LPVTCGKVKGMLYKKRLK--QGV-LEKCIQSEDGRWFTPKEFEAKGGHEKSKNWRMSV--
------RCGGRPLRWLMEK---EL LHN--PPRKYFRR----------R-KKIPR--THDN
ILVDPQ------------------------------------------------------
LGNSN ICEMCRRGGKLFCCDTCSRSFHEYCHIPPVEIERSP----WSCTIC RME-S----
-------FGRQPCHRES-EALER--QMQPEEQLK CEFLLLKIYCHSESS----FFSK---
-IPYYYYIREISQNLKEPMWLDKIKKKLNEQG-----------------YR---QVGDFV
QDMRLIFQN-----HRVSYKY-NDFGLMGLRLEKKF-------ERKFKEV----------
------FAIEETNESSSQA-----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------FSLRTVTKKEIKDILFKHYKKFKVEISKAIIKPFPFLE
GLRDREHITNEMYEDCQ----DSFR-N-LTPLHK-VVYKVLLEMEKAFDMEVLDA-----
--LFSQVNMQEYPELTLIHQSFVYGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------IQ--
---------------------NVEGQ-MQEQVCPEPIFRFFRENKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--SPLQMNNVN---------DLED---
--RPRLLPYGK--QENSNAC----HEMDDIAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPKASGG--------------DAEDAP
S------LLPGG---GV-SCKLAIQ---------------------IDEGESE-EMPKLL
PYDTE------------V---LE-SNGM---TDAARTYST--APGEKQGEEEGRNSPR--
-----------------------------KRN-------------------QDKEKYQES
PE-GRDKETFDLKTPQV-TNEGE---PENGL-------------------CLLPGEGEEG
S-D-DCSEMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-TFDLKTPQV--------------TN-EG---EPEK--------------------
-------------------K----------------------------------------
-----------------------------LGLLPGEGEEGSDDCSEMCDG-EEPQEASSS
LARR-------------GSVSSELENHPMNEEGESEELASSLLYDNVPGA--------EQ
SANE-------NEKCSC-VMCFSEEVPGSPEAR---------------TESD--------
---QA--CGTM-DTVDIANNSTLGKPKRKR---RKKRGHGWSRMRMRRQKNSQQ------
---------NDNSKADGQLVSSE-KKANVNLKDLSKIRGRKRGKPGTH------------
------F-----------------TQSDRAAQKRVQ----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLQ--QGI-LVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GFLPD--PPRIRYR-----------KKKRILK--SHNN
NSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WNCIFCRMKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGFRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TGLAEGS---------SLRTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLSGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
ASTVP------------------VASDN-----------------------------LIS
QIKDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKRKHKKKSLPRALRPTGLPVPPRLKGSPMPFPPEVACGYHDAASPRHGIQKKLKV
VDQVPQKKDDSTW---NTTVVTRVQKARAECARNSRSEEITDYTSKMNEG-KRSQKTPST
PSRVTQEERRKEYG----QSSSK-------------------------------------
-------------------R----------------------------------------
----------------------------------KQKKKLSRE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSIQKAR-TECAQKSRS---------------
-------------------------------------------KGKPK-SDP-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLAELLKV-----------------------------------------
-----------------------------------------------------------L
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------ETIFSHYRKHKVEMANAIKKPFPFLE
GLRDRGFISDKLYEDSE----ESCR-N-LVPIQK-VVYNVLKELEKTFDLPLLGA-----
--LFSEVNKKEYPDLTHICRGFEDVIK---EKL---HLQEHEK-------------E---
--MPNIQPSLE-QDPCVFIS----ASS----PSSGE---TRSLSSE--------------
--------------LLRSSDRSN----------IN----LELKNLNTVEG-----HQYPE
PA-------AS------GSSEQVAIQ-------------------VNNGDARQ-EVPSPL
PSNEE--------------G-AELSTRG---VQTNSCSVH-----------------LV-
DIKKE-K----------------TFHYQGV--QASTN------------------RAQ--
--ASDVIVISSEDSEES-N-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------EE-GEPLEAYTS
APTNL------------------------------------------PDRK--------P
PRLGK--------KRHSKITVFSTLLT---------------------------------
---ER--RDFR-ESPVF-------------------------------------------
------------------------------------------------------------
-------------------------------GKSSRK----RGKRK--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYERQSGDT---------P------
-----ILIEAP-TGLAEGS---------SLHTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
TSTVP------------------VASDN-----------------------------LIP
HIKDKED------------------------PQQMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKKRHKKKSLPRN-----------------------------AASPRHGIQKRLKM
VDQVPQKKDDSTW---NSTVVTRVQKARNECARNSRSEEITDDTSKMNEG-KRSQKTPST
PSRVTQGKTWR-------SLV---------------------------------------
------------------------------------------------------------
----------------------------------SEYSHQ--------------------
-----------ESKFR--------AK-------KR-EVSYKLKLEGP-------------
----------------EKKKEKDIC------------------SRKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------HCGGTTLGELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRQLNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYTKLDIAYAINKPFPFFE
ALRDNSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFDPSMLLI-----
--LFSKVNLREYPSLGAICRSFRN---VGN-----AYEGRNRPA---------P------
-----TLLGAS-TNPAEGC---------SFQTLLPQPRSQALPPSHLSSGLRIRDPGTTS
-------LQITEILDEQPSPSHPA------------------------------------
----------------------APLPGYIREGKTTPGSSRDH--QRKDKEDSQ-EMPHHP
SGPEA------------------VVKDI-----------------------------LTS
KTNNRDD------------------------SGAQP-------------------PG-SP
GTMH----VVQD------------------------------------------------
----NSPAPNDPE---VPQEAPCTPANK--------------------------------
----------------------------------------KARK-RKS-----------C
IWSNSKRRRQKKKPPQ------------------------HKM-MGVASPGPGVQEKLKV
VGQRTLNQDDSTR---NVKVVTRTLRERTRCAQTSSSQEISKEASKPRAR-KRPQKRPHT
AGRT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------IHVPEKSK-DDA-VDFLSPT
LSVTCGEARGTLFKEKLK--QG-SSEKCIQNEAGAWLTVKEFLKKGGKATSKDWKKAI--
------RCNKKTLRSLEQD---GFLFC--TSKSKPQK---------------E-------
-----------------------------------------------------------C
D-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------LPRASTE-----DQNIDDRLIYETLFKHFKRHKVEISSAIRKPFPFFE
CLRDREFITNKMYDDCQ----DSCR-N-LVPVQR-VVYNVLNELEKTFDLPLLEA-----
--LFSEVNMQEYPGLKHIYRSFKHGRHDLIYSI---DYQGSDEE---------DVPG---
--GPSIQANHE-QETDENSH----R-S----LTWSC---PQSSSYH--------------
--------------GTTPPANGLLE-KLCEPEQINAKRTDATSDKNDALEIQQVNEECAQ
E------SEPA------ESCEQPPSQ-------------------VDNGDTRE-DTPSPL
PRDGE------------KAR-AELPNHG---IQLNPCSVS-----------------LV-
NIKKEKP-FFNLR--------------VERQAQARAN------------------CDQ--
--ASDIIVINSD-SEES-RDEDEPPEPPEASTSA---------------LESRP----VT
NNL-DSLESSEKG---ESQEATCSPPELDSVEGKRGN-RSL-----RTLAS-SAVKRF-D
DSSE-SSEEEEP--LTASS---SALRSDSD-EE---DPAD---V-GNK-----------F
TWGTNKR-----------------------------------------------------
-----------------------------------KRWISGDNFSELSHT-EQPQESSSS
VLRSG------------------------------------------SG--------AEP
KGL--GN-----QKCSC-VMCFSEGTSRGQRAR---------------AESS--------
---QA--SDIM-DTTDIGNNSASGKHREKKR--KKRRYTRRN---SSH----Q-------
--------------------------------TVR-----RRSRRRSQ------------
----TLNK-RTLQN---RGKPKGRKIVKTGSLRGGRK----RGQRIPR-DIH-MNFSHPQ
LPVTCGEAKGILHKEKMK--QGT-SEKCIEAMNGKWLTLREFEVEGNRSQSKNWKMSV--
------RCGGFPLKDLIEN---KSLPD--PPRRRRRR-------------VI--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------RR----KRGPRIPR-EEN-ADFGGAE
LPVVCGNARGFLDKEKFK--QGI-YVKSIRSETGRLFTPMEFEIEGNFEKAKNWRQSI--
------RCKGWTLRELTQK---GVLQD--PRRKKKET------------PR-------NP
-RQTRRQ-----------------------------------------------------
RGNPKACKVCGQPRKVHPCTACKEFYHKNCHIPPVEDKSSS----WHCAFCKRKNQL---
----R-GQKTQACHKEA-EVLKR--KMSPEEQLKCELLLLTIYCYPKSG----FFIP---
-KPKQ--RKEKFPDLREHMWLNKIKNRLNKKA-----------------YH---SVRHFV
EDMRLIFHN-----HSIFYK--SRFKNLGIIVGKKF-------EKNFKRI----------
------FSIKDTSEQHEPCKHTVLLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFGVIQKEERFNEVFLNYFKENKIEIAHAITKLFPFLE
SLRDHSFITDKIYADSY----EACR-N-SVPIVE-VVYNVLSHLERLSDSSFLWA-----
--LFNRVNLKEYPALREIHKSLGTELQ---DGY---SPQKCKQE---------EQKK---
--LATVHPSYE-QGTNLCTH----------------------------------------
-------------------------------------------------------EKWAQ
PC-------FV------K---QDNLQ-------------------EPEIQ----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--VDEIIVISSESSECS-DEDEE-----H----------------------Q--------
-------------------------A----------L-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GTGLRRQMDKE-AE-------
-DSSP------------------------------------------PGFQN-----IEL
P-AGS--------HTSCVWTNHS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
--------------MLICCDSCPNSFHEDCHIPKALSSSPE----WICTYCRMEKAE---
----KRCPPNVARHPEL-QVLKM--KMLPEELLKCEFLLLKIFCLYDSK----IFIE---
-DPERI--KDYYQHIKEPMWLNLIKERLHQGM-----------------YN---TIEGFV
LDMRLIFKN-----CWKFNKN-NKFGQMGIKLKKVF-------EKNFKQV----------
------FSIQEIEEAC--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------MFTMTKTLEAALFQHFSHQKLEIAYAIDKPFPFFE
GLWDKSFISDRQYGXXX----XXXX-X-XXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXFTTYEEW----------------NR-----------------
----ATEVPVD--LSGGCF-----LQA----LPLPPPPQLSPPSQ---------------
--------------QPHVSRDGEP------------------------------------
----------S-------SAPAERLGGLVQEERGT-------SVTNDNLM--S-KV----
----------------------SEEEDS---QEMPNSSGT-----------------MQ-
XXXXXXXXXXX-X--------------XXXX-XXXXX-------------------XX--
--XXXXXXXX--------XXXX---XX---XXXX---------------XXXXX------
--------XXXXX---XXXXKKRKRSIWS--------TPKT-----R--HQ-KRSLPK--
------------------------------------------------------------
-------------------------------------------R--AASPEQGTQERLQV
MHQVTRKKNSSTW---KSEVMTRAQKARARCAQTSRSEEISNDTSEMNER-KRSQETPWT
QLKVNHXXXXXXXX-------------------------------XXX------------
---------------X-----XX--XX--XX-----------------XXXX--------
---XX---XX----XXX----XXXXX-XXXX--X-------------X-----X------
--------------------------------XX--------------------------
--------XXXXXX---XXXXXXXXXXXXXXXXXXXX---XXXXXKPA-DDP-VDFHALE
LPVTCGEAKGILYMKKLQ--QGS-SEKCIQNKEGVWFTPKEFELEGKKKNSKDWKRNL--
------HCGGQTVRQLLEX-X---------------------------------------
------------------------------------------------------------
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPH----GSCTFCGMKSSS---
----VQQR----H-------------PESEERLKCESLLLKACCHPQGF----FLAE---
-RPQNI--RDYGEPFKEALWLSLVTERLAEEV-----------------YVVAWV-P---
-DVPLIFHN-----HKSFHK----------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------M----EACE-N-LVPLSR-VVYNILTQLEKTFSLSFLKI-----
--LFSQINLNEYPNLITTLNSFTRVVT---SHG---GWSRITT-----------------
-----TLLEAP-ANPAGRSS----PRT----LLLPRLPCRQPLRSLPPCGPSVSERAP-A
-------QRSSEVLRELPSRTGLTM-TLRET--IQKGRLSP-------------------
-----------------VSSDSLTPQ-------------------IKDKEDTQ-E----M
PCTSS-------------------------------------------------------
------------------------------------------------------------
----DPVPVKRDDVPEP-------------------------------------------
---------SDPK---ELQEAS--------------------------------------
-------------------------RT---------LPSKKGKK-RKR-----------C
IWATSKKRQQKNSHQGSKMRKQEG----AGG-----QRQLIPVDQGAALPGHGIQKTLQG
LDQVTHTEDDSIR---NTKVMTRTQKRRTECAQMPKSEEISDNTSEMDEG-KRSQEPPST
PPRIT-------------------------------------------------------
------------------------------------------------------------
---HG--KDSMDDDSKL----SLEKSPGKKQ--KKRKIHNWSSSKKRQKKCLSK------
--------------------------------G------AASSGLRIQEK----------
--------------------LQGVNQVTQKKDDSTRK-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------FFAS---
-KPHYS--REASHGPKKPMWLNKIRKKLNMKL-----------------YL---QVKGFV
RDMRLIFQN-----HRAYYKDNQKFIKLGLQLEAIF-------ENTFKNT----------
------FAIQETGENSSQLEPNL-------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMVTD-----------IQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNVN---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DAEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGP-------------------CLPDEGE-S-
----------------------SSVARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGSGDCSQMCDG-EEPQEASSS
LARC-------------GSVSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKNVQQ------
---------HENSKADGQVVSNE-KKVNVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SYNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREMCQGLKEPMWLDKIKKKLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKHFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEQALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKRMYLESL----EACR-N-LIPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGA-----SYERQSRDT---------P------
-----ILLEVP-TGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPALIQEGRSTSVTNDKLTSKMNAEEDSE-EMPSLL
TSTVQ------------------VASDN-----------------------------LIP
QIRDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDPE---ELQEVSSTPSDK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKRRHKKKSLPRG-----------------------------TASSRHGIQKKLKR
VDQVPQKKDDSTC---NSTVETRAQKARTECARKSRSEEIIDGTSEMNEG-KRSQKTPST
PRRVT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------ASPGHGIQE------KLQVVDKVTQR
K---------DDSTWN--------SEVMMRVQKAR-TKCARKSRSKE-------------
----------------KKKE-KDICSSSKR--RFQK---NIHRRGKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNI--
------RCEGTTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRML----WSCTFCRMKRF----
-------SGRQQCRHVS-KTLER--QMQPQDQLKCEFLLLKAYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLMFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKDV----------
------LGFHEANDGGFWTLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNE---------------
------------------------YQDVDERVLCDAVFKHFKRYKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKIFNLPVLEA-----
--LFSDVNLQEYPDLIHIYESFKNETK----KG--L------------------------
------------------------------------------------------------
----------------------GEM-HPCETEEINAERKGTTSDKNGSLGSQQTNEQRAQ
K------AEPT------ESCEQVTIQ-------------------VNNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YFTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PPEVFISP---------------LRNEP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPTDYRKSSIF-----REMFR-KRATGQDY
NFSD-SSEEEAPPEVS--S---RALRSKHG-EK---DRVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSCDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCRC-VMCFPKGVPRSQEAR---------------TESG--------
---QA--SDTM-DTMDVENKSTLEKHSGKRR---KKRKHIFKANG-LQRG----------
---------------------------------------RKKHRPRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RG-PRIPR-DEN-INFKQLE
LPVTCGEVKGTLYKKKFK--QGI-SKKCIQSEDERWFTPREFEIEGGRKASKNWKLSI--
------RCGGYTLKFLMEV---FYLSV-----FFQ--------------QRILE--SHNN
TLVDPY------------------------------------------------------
PENSNICGVCNKWGELFCCDTCPRSFHEHCHIPPVEAKKNP----WSCIFCRIKTIQ---
---ERC-PESQPCHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KEGSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVQDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SEHEN-TETFPFELIFQHFKRQKVAISNAIKNPFPFLE
GLRDHELITAKMYEDLQ----DSYR-A-LVPVDK-VIYRALDELEKTFSMKVLCE-----
--VFSNVNMEKYPDLQLIHQSFEHVLP----NG--LCFQRSDGG----------------
--DPNSQLSLE-QG----------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SSKHR-DET-VDFQALL
LPVTCGKVKGILHKKKLK--RGV-LVKSIQSEDGNWFTPKEFEIKGGYARAKKWRLSL--
------RCGGYPLQWLMEK---KFLPN--PPRTYCR-----------KNKRIWT--SHSN
TLVNPC------------------------------------------------------
KRNLDECEVCRDGGTLFCCDTCPRVFHKECHIPAVETGRTP----WSCIFCRMKEF----
-------SGSQQHHRES-EVLER--QMQREEQLKCEFILLKVYCCSESS----FFAK---
-IPYYYYIGEACQGLKEHMWLDKIKKKLDEQG-----------------YT---QVERFV
RDMRLIFQN-----HRASYKS-NDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------V
N------ETNDLPTS-TLQNVSGEEQDMDERFFYETIFNHFKKHKVEISHAIKKTFPFLE
ALRDRDFITNQIYNXXX----XXXX-X-XXXXXX-XXXXXXXXXXXXXXXXXXXX-----
--XXXXXXXXXXXXXXXXXXXXXXXVR---NKL---GLPESDGE---------ETEE---
--RHNIPLSLE-QXXXXXXX----XX-----XXXXX---XXXXXXX--------------
--------------XTPLPENGLSE-HIYEAEEIE-----ETTGEKNAQENQQANKKCAQ
E------SEPA------EVCKQIPQV---------------------DSGDTG-EMLSKV
PCDGE------------XPG-TELLSNG---IQINSCSVP-----------------LV-
DIKKEKP-FFYSQ--------------VGR-------------------------RAE--
--NCDVIVISSEDSAEELSDEDE---ALEVYTSA---------------AEDEH----VI
NG---LLELSEGE---ELQEVTCSRPQIVPDTVGFKPLTVN-----M---------EHNC
DSSD-SSDNEMPP--EALG---SARRRKLG-EK---V------F-MIP-----------S
KPTKIIM-----------------------------------------------------
-----------------------------------KTRIGSGDSSEWSNR-EESRETCSS
ALRSG------------------------------------------SG--------AEL
PRPEN-------KNCSC-VMCSTEDVPSGQGAR---------------TESS--------
---YA--PDFT-DTMDVGNNSTLGKHSGKGR--KKRRHIHQV---NHLRG----------
----------------------------------------KRGRPRIP------------
----STLRNKVPRK---RVRPRG-ERINTGPIKRRRK----GSPRIPR-DKN-INFQVDR
LPVTCGKVKGTLYKDKLK--LGI-SVSAIQRE-RRWFL-REFV---SVVNSKNWKLS---
------RCGGWPLKWLIQX---XXX XX--XXXXXXXX-------------XLEN--NNT-
-SPDPY------------------------------------------------------
PGNSN TCAVCSRWGRLYCCDTCPRSFHQDCHIPPVN--RDP----WNCIFCRV GAIQ---
----KRYPESQPCHQEL-EVLMR--LM QPEEQLKCELLLLKIYSHPKSL----FFAP---
-KPFYS--RDSAQGLQEPMWLNRIKKRLAEKA-----------------YS---RVKDFV
QDVRLIFKN-----HKVFYRG-RKFLRLGLQLEAEF-------EKNFKNI----------
------FAIQERSND---------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------MEAGKSTICSVG
Q-----------------QGR---------------------DRG-----------DR--
---------------------NIEDQKVEEQICPELIFRHFKENKVEIASAITKPFPFLM
SLRDRSFISEQMFENFH----EACR-N-LVPVAR-VIYDVLSELEKTFDLSLLET-----
--LFSSVHLKTYPDLNEIFRSFQNVYK----HS--PHLLL--------------------
------------IRKGSNAC----PETRDVEEPQEA---LRS------------------
---------------PPSCGP-----ASCEQVVLQRTNGE--------------DAKEIP
K------LLPGS---GRESWNLTVQ---------------------MDEEESE-EMPRLL
PYDRE------------G---RK-HGNG---A----------CP---LGEETSR-IRE--
-----------------------------KR---------------------H-------
RNKRQEKPTCDLQTPQM-TNEGE---PEKEL-------------------SLVADEGEES
S-N-ACLEMCDGK---EPQGASSLLPTC---------------------------VPVSC
G-------PEAPQM--------------TN-EE---EPEQ--------------------
-------------------V----------------------------------------
-----------------------------PSQLLGDGEG---NCTLVFPS----------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------TKVKRKQQKKIQQ------
---------NGKQADQAWWLTPVISELWEAEKSS--------------------------
----------------------------------------LSASRMRG-YET-VDFQAPS
LPVTCGEEKGILHKNKLK--QGA-WVKCIQGEDGNWLTPGEFEIKGGHAKAKSWRMSV--
------RCGGLPLRKLMEM---QR-------------------------QHVLD--SHNG
GL---PR-----------------------------------------------------
LENLDECEVCRDGGLLFCCDTCSRAFHEDCHIPPVGNERTP----WSCIFCRMGEF----
-------SGSPRCHQES-EILER--QMGPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREASQGLKEPMWLNKIKKRLNEQG-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-NNFGQMGLRLEAEF-------EKNFKEV----------
------FAIQKTNENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------IQ--
---------------------NVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNQIYRSFQNVCY----EH--SPLQMNNVN---------DLED---
--RPRLLPYGK--QENSNAC----HEIDDIAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPKAGGG--------------DAEDAP
S------LLPGG---GV-SCKLAIQ---------------------IDEGESE-EMPKLL
PYDTE------------V---LE-SNGM---IDAARTYST--APGEKQGEEEGRNSPR--
-----------------------------KRN-------------------QDKEKYQES
PE-GRDKETFDLKTPQV-TNEGE---PEKGL-------------------GLLPGEGEEG
S-D-DCSEMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-TFDLKTPQV--------------TN-EG---EPEK--------------------
-------------------E----------------------------------------
-----------------------------LSLLPGEGEEGSDDCSEMCDG-EEPQEASSS
LARR-------------GSVSSELDNHPMNEEGESEELASSLLYGDVPGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGSPEAR---------------TESD--------
---QA--CGTM-DTVDIANNSTLGKPKRKR---RKKRGHGWSRMRMRRQKNSQQ------
---------SDNSKADGQLVSSE-KKANMNLKDLSKIRGRKRGKPGTR------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLQ--QGI-LVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GFLPD--PPRIRYR-----------KKKRILK--SHNN
NSVDPC------------------------------------------------------
------------------------------------------------------------
---------------------------------KCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGFRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

---------------MY-----------RIRVS------------------HGKITAGRE
AVGRWVPSSHCCRGWTPMPPPPIPRSLGRSQLATCPPPNPNCQDTLRASQVSLRRWRE--
AAGTDLPSASCLANSKQFHFSFLRRLAPYCVYQSTDFLFCLLASPRKSPSLSGVIPGPVP
GTWKRA-GTTSPASRM----------FTMTRAMEEALFQHFMYQKLRIAYAIHKPFPFFE
GLLDNSFITQRMYMESL----EACR-N-LVPVSK-VVHNVLTQLERTFNLSLLVT-----
--LFSPINLHEYPNLVTIYRSFKR---VGEQQSRASCEQQSRGT---------P------
-----ILLEAP-TDLAGGS---------SLPTLLPLPPPQTPQPSCSSCAPRVREPGTSS
-------QQSDEILSESPSPSDRT------------------------------------
----------------------LPLPGLIQEGRNSPVTSDKLTPKMNEEEDSK-EMPSLL
ASTVQ------------------VASDN-----------------------------LIP
QIKDNEG------------------------LQEMP-------------------RS-PS
GPMP----EIRD------------------------------------------------
----DSLEPNDSE---EPQEVSSTPSKK--------------------------------
----------------------------------------KGKK-SKR-----------C
IWSTPKKRQKKKNLPRG-----------------------------TASPRHGIKKKLKV
VDRVPQKKDDSTW---KSTVMTRAQKARTQHAPKSRSEEISDGTSKLNEG-KRYQETPST
PSRVKQEKRRKEYG----LSSSK-------------------------------------
-------------------RKQNKKLPRGA------------------------------
----------------------------------TSPGHDIQE------KLQVVDKVTQR
K---------DDSTWS--------SKVMTRVQKAR-IECTQKSRLEE-------------
----------------N-----------------------------LK-SDT-VDFHWSE
LPVTCGEAKGILYKAKMK--HG-SSTKCIQNENGAWLTPKEFEIEGKGRDTKNWKRSI--
------RCRGKPLLELLKW-----------------------------------------
-----------------------------------------------------------K
--NSDQCEVCCKGGQLLCCGTCPRAFHEDCHIPPVEAKRTP----WSCTFCRMKRS----
-------SGSQQCHRVS-KILER--RMQPQEQLKCEFLLLKAYCHPQSS----FFTA---
-IPLNI--RDYGEPFQEAMWLDLIKERLITEM-----------------YTVAW----FV
RDVRLIFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDVKDV----------
------FGFHEANDSSFRTPP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------EGRGGDLSTRRLNECISPTANETNHLA--
-------AHSHDLQRMF-----TEEQDVDDRLLCDIVFKHFKRHKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSLR-N-LVPVQR-VVYHILSELEKIFNLPVLEA-----
--LFSEVNMQEYPDLIPIYKSFENVIH----DK--LPLQESEGE---------EREE---
--RPGIQLSLE-QGTGENSF-----RS----LTWPR---SGSPSHV--------------
--------------GTTPPENGLSE-HPCETEQINANRKDTTSDKNDSLGSQQTNEQHAQ
K------AEPT------ESCEQVTVQ-------------------VNNGDAGR-ETPCPL
PCDEE------------SP-EAELHNHG---IQINSCSVR-----------------LV-
DIKKEKP-FSNS--------------KVECQAQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDDDE---PSEVFISA---------------PRNEP----VI
NND-NPLESNEEK---EGQEATCSRPQIVPEPMDFRKLSIF-----RERVK-KRVIGQDH
DFSE-SSEEEASPEAS--S---GALRSKQG-EK---DPMTSRST---------------S
TWRIPSRKR---------------------------------------------------
-------------------------------------RFSSSDFSDLSNG-EELQKTCSS
SLRS------------------------------------------GSGS--------EP
QEPE-------SEKCSC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDAENNSTLEKHSGKRR---KKRRHRSKVNG-LQRG----------
---------------------------------------RKKDRPRKH------------
----LTLNNKVQKK---RWQRRGRKAN-TGPLKRRRK---RG-PRIPK-DEN-INFKQPE
LPVTCGKVKGTLYKERFK--QGT-SKKCIQSEDKKWFTPREFEIEGDRRASKNWKLSI--
------RCGGYTLKFLMEN---KLLPE--PPSTRK--------------KRILK--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGQLFCCDTCPRSFHEHCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQSGHQES-EVLMR--QMLPEEQLKCEFLLLKVYSDSKSL----FFAK---
-EPYYN--REGSQGPQTPMWLNKVKRRLNEQV-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFIRLGIQVQDIF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MLIFKRFRENKVEIASAITKPFPFLM
SLWDLAFISEQMYKHFQ----ETCR-N-LVPVTR-VVYEVLHELEKTFTSSLLQV-----
--LFSKANLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRRLNG----VANEMNHLP--
-------AHSQSLQRMF-----TEDQDVDKGLLYDTVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFNEVNMQEYPDLIHIRKSFNNAIQ----DK--LFFQESDRK---------EREE---
--RPDIQLSLE-QEVPESPE-----AK---------------------------------
------------------------------------------------ME----------
---------ND------QACGK--------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------M---DTVDIGNN---------------S
TLGKPKRKRKRK-KGHSWTR----------------------------------------
-----------------------------IKSRTQKK-FQQHDNSK--------------
-----------------------------------------------AGG--------Q-
------------------------LIPKEEKAK---------------------------
----------------------------------VNLQGLSKISG---------------
------------------------------------------------------------
---------RKRSKPGTRFTHS-----DRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGD-FLKCIQTEDGNWFTPAEFEAKGGYARSKNWKLSV--
------RCGGWPLQRLMKE---GSLPN--PPKIHYRNKK---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGGDLSTRRLNECISPVANETNHLP--
-------AHSHDLQRMF-----TEDQGVDDRLLYDIVFKHFKRHKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKIFNLPVLEA-----
--LFSDVNMQEYPDLIHIYKSFENVIH----DK--LPLQESEEE---------EREE---
--RSGLQLSLE-QGTGENSF-----RS----LTWPP---SGSPSHA--------------
--------------GTTPPENGLSE-HPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
K------AEPA------ESCEQVAVQ-------------------VNNGDAGR-EMPCPL
PCDEE------------SP-EAELHNHG---IQINSCSVR-----------------LV-
DIKKEKP-FSNS--------------KVECQAQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDVDE---PLEVFISA---------------PRSEP----VI
NND-NSLESNDEK---EGQEATCSRPQIVPEPMDFRKLSTF-----RESFK-KRVIGQDH
DFSE-SSEEEAPAEAS--S---GALRSKHG-EK---APMTSRST---------------S
TWRIPSRKR---------------------------------------------------
-------------------------------------RFSSSDFSDLSNG-EELQETCSS
SLRR------------------------------------------GSGS--------QP
QEPE-------NKKCSC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRRHRSKVNG-LQRG----------
---------------------------------------RKKDRPRKH------------
----LTLNNKVQKK---RWQQRGRKAN-IRPLKRRRK---RG-PRIPK-DEN-INFKQSE
LPVTCGEVKGTLYKERFK--QGT-SKKCIQSEDKRWFTPREFEIKGDRGASKNWKLSI--
------RCGGYTLKVLMEN---KLLPE--PPSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGRLFCCDTCPRSFHERCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQLGHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDSKSC----FFAS---
-EPYYN--REGSQGPQKPMWLNKVKRSLNEQI-----------------YT---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFTRLGIQVQDIF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGGDLSTRRLNECISPVANEMNHLP--
-------AHSHDLQRMF-----TEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSDVNMQEYPDLIHIYKGFENVIH----DK--LPLQESEEE---------EREE---
--RSGLQLSLE-QGTGENSF-----RS----LTWPP---SGSPSHA--------------
--------------GTTPPENGLSE-HPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
K------AEPT------ESCEQIAVQ-------------------VNNGDAGR-EMPCPL
PCDEE------------SP-EAELHNHG---IQINSCSVR-----------------LV-
DIKKEKP-FSNS--------------KVECQAQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDVDE---PLEVFISA---------------PRSEP----VI
NND-NPLESNDEK---EGQEATCSRPQIVPEPMDFRKLSTF-----RESFK-KRVIGQDH
DFSE-SSEEEAPAEAS--S---GALRSKHG-EK---APMTSRST---------------S
TWRIPSRKR---------------------------------------------------
-------------------------------------RFSSSDFSDLSNG-EELQETCSS
SLRR------------------------------------------GSGS--------QP
QEPE-------NKKCSC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRRHRSKVNG-LQRG----------
---------------------------------------RKKDRPRKH------------
----LTLNNKVQKK---RWQQRGRKAN-TRPLKRRRK---RG-PRIPK-DEN-INFKQSE
LPVTCGEVKGTLYKERFK--QGT-SKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSI--
------RCGGYTLKVLMEN---KFLPE--PPSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGRLFCCDTCPRSFHEHCHIPSVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQSGHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDSKSC----FFAS---
-EPYYN--REGSQGPQKPMWLNKVKTSLNEQM-----------------YT---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFTRLGIQVQDIF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRALEDTLLQQFIYQKLEIAYAIYKPFPFLE
GLRDNFFITETMYRESM----EACR-N-QVPIPR-VVYNVLTHLEKNFSVSFLEM-----
--LFSRINLHEYPHLMTILKGFRS---VVN-----CCGGWSRAV---------P------
-----TLLEAP-ANPAEGC---------SLQTLLPLPPPQSH----PPHAPSIMEPSTST
-------QHSAEIVGEPSSPSDPA------------------------------------
----------------------VTLPRATQEESITPVTNDNLTSQINDDEDSQ-GTPGTP
SDTVR------------------VSGNN-----------------------------LSP
QINDKEM------------------------LKRCP-------------------HQ-AP
CQPPEVKLVMSD------------------------------------------------
----DSPKPSGPR---ELQEAPSTPLRK--------------------------------
----------------------------------------KGKK-RKR-----------S
IWSTPKKRHQKKRLPKG-----------------------------RTSPQHKSQEKLQG
VDQAPQRKDDSPR---KSNVMTRAQKAKAECAQTAGPEEISEDFSEMNEE-KSPQEPPST
LPRILH------------------------------------------------------
----------------------------DA------------------------------
----------------------------------ALPGHSIQE------KLRVVDQAPER
K---------DDSTGH--------SKIMTRAQKAR-IECVPTSELKE-------------
----------------KKR-EKGVSSSSTR--RCQK---NIPRKQKPK-DET-MDFLSPE
LPVTCGEAKGILYKEKLK--QG-SSEKCIRNEEGVWFTPKEFEIEGKRTKTRKWKQTV--
------LCRGKTLEELLKK-----------------------------------------
-----------------------------------------------------------K
VVGDKGCEVSCQQGSGLCCGQLRGPLEHSCSLPWGRARPSP----WSCTFCRIKES----
-------LGRQQRHRES-EVLQR--QMQPEEQM---------------------------
-----I--RDYGEPFKEAMWLDLIKERLTEKV-----------------YTVAW----FV
RDMHLIFHN-----HKTFYKA-SVFGQIGLDLEEEL-------EKDLKEV----------
------FIFCKVNESSFQTL----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------ME
G------PGSSLSTRMSTE-----DQNLEDRFPLESVFQHFKKYKVEISKAIKKPFPFLE
GLRDRGLINDKMYEDLQ----DSCR-N-LIPIHK-VVYRVLDQLEKTFDLMVLEA-----
--LFSEVNMEEYPDLEHINRSFENVIQ---NKL---CYQRGNAE---------QRGE---
--DPNSQLSLE-QGPGENCS----QRS----LTWSP---LDPCCSD--------------
--------------DWRSNERRN----------TN--------QKYKTES-----HRRSS
P------LNHI------DSCELIEAQ-------------------GHSGGASL-EAPSRL
TRKEE--------------R-VEPLTNG---IQINPCSVQ-----------------LV-
DIKKEKL-SFCSE---------------EQQNQASVY------------------HNQ--
--ASDFIVISSED-SDD-GE--------EACTSA---------------PSW--------
-----------------------------SKPVDSRK-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------SPTL-TKMLVK----------
---------RGRKR-------------------------------SFLGNYF--------
----IQN-IKTPMQRGWSKAFSGRRV----------------------------------
-------------KSRT-------------------------------------------
------------------------------------------------------------
-------------------------------SERGRK----RGPRIAR-GNN-VNFDLPE
LPVTCGDVKGTLYKEKLK--QGI-WKRSIRSENGRWFTPRQFEIKGKHKKSKNWKLSI--
------RCDGWTLKELIEK---EHLSN--PPRAKKNV-------------TLR-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------MAD
G-------GRDLSTRMLTD-----APHAED--LMVTLFQYFKAHKVEISYAIKKTFPFLE
GLRDRELITNKMYKAYQ----DSCR-ESLVPVHR-VMYNVLNDLEKIFDMAVLEA-----
--LFSEVNREVYPALMNIYKDFQNVIH---DKL---YLQESDGE---------EREE---
--RPNTQLRLE-EGTRRNSV----SRS----LTWSR---SEPSPSG--------------
--------------GTNLPENELPH-QAHKREQINGLRTETTKERNDTPGSHQTDEQPVQ
E------SAPG------KSLEEVAAP-------------------ANNGDASV-EPLRPL
ACGEE--------------R-TELHSQG---IQVSSCSVL-----------------LV-
DIKKEKP-FYS-E--------------DEQRAQRRAK------------------PAR--
--PPDIIVISSDDSEDL-SDEDE---PPKASTSA---------------LRSEP----VI
SDH-DPLESSEEE---ETQEASCSRQS-TPKPMDFRTF--------RKSPL-KRGREHVH
NSSE-SSEEETLPQIDFCS---SEWRSGPS-TT---EPVH---T-GKP-----------S
TWGTYNW-----------------------------------------------------
-----------------------------------KRWLNSGGSSXXXXP-N--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
G------GDNELSSRTIP-----EDQNEEESDDYQLMFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LVPVER-VVYDVLSNVQKKFSWDLLKV-----
--IFSKTHLKAYPDLKETLKHFFLNA----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------S-------------------KTNDEQAE-EMLSLP
QCNGG--------------E-GSS----------SCEQTR------------------DE
QEPQDDL-PSSLRQEAARRKKRPNWSNSKRRL--QKK------------------KPR--
--QDEMMGVASPGH-GV-QEKLK-----AVSRRT---------------LWKDD----SS
TN-----------------------VKEVTKTLRARI-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------RCGTCHWKG------------
------------------------------------------------------------
----------------SAWANLSELVQGSRDT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNIAYAINKPFPFFE
ALRDKSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFPPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---GNV-----VSPILVTCA---------V------
-----VLQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------YTVPRALEEALFQHFIYQKMDIAYAIDKPFPFVE
SLRDKAFITNRMYKESL----EACR-N-LVPVSK-VVHNILTKLEKTFSLSLLVT-----
--LFSEINLHEYPSLVKIFKSFKS---VMA-----SYGQWSRAT---------P------
-----TLLEVP-TGPAEGC---------SLQTLPLLPPPPPPPPSCPLCVSRGSEPGASS
-------QRSNEILGEPPSSSDPA------------------------------------
----------------------VSLPGLIQEGRRTAVTNDNLTAKMNEEEDSH-KMSSPP
PGTAQ------------------ASSDN-----------------------------LSP
QIKDEED------------------------SQEMP-------------------HA-PP
GPTP----VVRD------------------------------------------------
----ESLEPNDPK---EPQEVSITPSNK--------------------------------
----------------------------------------KAKG-MKR-----------E
VTDWDRRRLTGDPNLNYS---------------------QITLGPGTALPGQGTQEKLQV
VDQMTQRKDDSTR---NLKVVTRTQKTRTEFAQTSRSKDISDSTSEMNKG-KKSQETPST
P--PTATQ----------------------------------------------------
----------------------------EA------------------------------
----------------------------------TSPGHGIQE------KLPVVGQATQR
KT--------DDSTCN--------SKIMTRAQKAR-SKGKR-------------------
--------------------KKGTCSSLKT--RFQK---NIGRREKPK-DDS-MDFQCPD
LPMTCDKEKAILHVERMK--LG-PSKKCIQNEEGVRLTAKEFEMKGKGRSTKDWKQRN--
-------CEGSPLGFRML------------------------------------------
------------------------------------------------------------
A---------VFRGLALCRPYVQS-------------LRTL----WGCAFCRTKAS----
-------SGSQQCHRES-KIPGR--QMQLGEQLAC--------CHPQSS----FFAE---
-IPCNI--QDYDKLFKEAMWLDPVKERLIKEV-----------------YTVVW----FV
WDMRLIFHN-----HKTFYKA-SNFGQIGLDLEAEF-------EKDLKEM----------
------LGLHEA------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------I--------AGANNQLSPXXXXX---XXXXXXXXXXXX
X------XXXXXXXXMSRE-----DQGLEDGLFYEAVFSHYRKLKVELSHAIHKTFPFLE
GLRDRGFISNKLFTDSE----ESCR-N-LVPVRK-VVYNVLNELEKTFDLPLLEA-----
--LFSEVNLMEYPGLTDIHRSFTTXXX---XXX---XXXXXX-XXXXXXXX---------
----XXXXXXX-XXNGENF-----HGS----LPW---LYADSSSDV--------------
--------------DTIPPEDRLSD-YVSETERVNEGGREPTRSENEAAGGQQDSSACTQ
E------SDPV------GCSEQAALR-------------------MHSKDARQ-DMLSPL
SW------GQQIPG-------AELSTNGTP---IHPCSVL-----------------LV-
DIKKEKS-SYEPR--------------A-----QRTNCL------------------Q--
--ESDIIVIDSEDNDE-----DE---PPEASTWA---------------MRSQP----XX
XXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXX--XX-----XXX--XXXXXXARH
RDASGSSEEDEHPGTSHS-----ALGRLPA-KEG-----------SVH------------
---------------SRNTSPAEK----R-------------------------FR----
-----------------------------------IRGLINEDWTEVSDR-EEPPEASGS
VPRSG------------------------------------------SG--------AEL
PGPVM--------EHSC--VSWSSTVPGC---------TGSPSKV--PGRMA--------
-------------TVESGRSSIMGSHTKKRT--QKRNHLEGE---IKLHKGRKR------
--------------------------------LW----PRKLYGQR--------------
---------NNRLK---RGHSKGVNRVNAGPLRRWRK----RGLRIPK-DYT-INFQSPQ
LPVTCGEVKGTLYKEILA--QXT-SKKCIQTEDQRWFIPSEFEIEGGRGKSKNWKISL--
------RCGGNTLKSLIEH---GLLQK--PPRTRKRX-------------XXXX--XX-X
XXXXXX------------------------------------------------------
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNP----WSCIFCKIKAIQ---
----EDCQESQPCHQES-EILSK--WMQPEEQLKCEFLLLKIYCSSKSL----FFAK---
-KPRY-----------KPMWLNKIKMKLKKKN-----------------YH---KVGEFV
QDVRLIFQN-----HSTYYK----------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------LTVTNALKEALLQHFIYTKLDIAYAINKPFPFFE
ALRDNSFITEKMYKESL----QACQ-N-LVPLSK-VVHNVLTSLERTFQPSLLMI-----
--LFSQVNLREYPSLAAIFRSFKN---VRT-----AYEENKRTA---------H------
-----TLPKAP-TDPAEGH---------SFRTLLPLPPPEPSPPSHLSSAPRVCEPREAS
-------HQITEILDEQPSPSHTA------------------------------------
----------------------VPPPGFIREGKTTAESSRDP--PRNDKDDST-ETPPSP
SGSIP-------------------VK----------------------------------
------------------------------------------------------------
-----------D------------------------------------------------
----ESPAPNDLE---LPQEAPSTPANK--------------------------------
----------------------------------------KAKK-KKR-----------C
IWSTPKRRHQKKRPPQ------------------------VSLGPGVASPGLGVQEKLKV
VGQRTPRKGDSTR---TLKMVTRSQMAKTKRAQTSRSQEVINGASKTNGI-RRPQRMPSL
LPKT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T--QGKSN-DDT-ADFLSPI
LPVTCGKVKGILFKEKMK--QG-PSGKCIQNEAGDLLTPREFLIKGGKARSKDWKKTI--
------WCKGKTLRFLEQK---GLLLC--TSNSNLKK---------------R-------
-----------------------------------------------------------V
T-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M-----AAEEQ----DMEDDPIFRYFRENKVEIASAVTSPFPFLM
SLRDRAFISEQMYKHFQ----ESCK-N-VVPLAQ-VIYDILSELEKTFDLSLLKV-----
--LFSKVNMLAYPDLKEILRNFPNGNYNGDL-------------------------K---
--K---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------PKRKGGGEGGKKGRR--
-----------------------------EE-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------KERKER--------DQ
SARG-------NEQCPC-VMCSTKCVPEGPEEK---------------MESS--------
---QV--HDT-------------------Q---GRKKGHKWTKIKRRRPQNTYK------
---------KGSW-----------------------------------------------
--------------------------------------------KNRV-CEY-INFRSDL
LPVTCGHLKGTLNKNKLK--QGA-LAKCILSEDGNWFTPIEFEAKGGHARSKNWKISV--
------RCGRWSLLKLMEVSISRFLPR--PPRTYPKR----------TRTY-PK------
-RKKVVI-----------------------------------------------------
LRNSDECEVCRKRGTLFCCDTCSRAFHRDCHIPSVEAEMTP----WSCIFCRMEAI----
--------GSQQTHSEP-EILDR--QMWPEEQLKCEFVLLKVYCCSEST----FFAK---
-IPYYYYIRDTSTSQKKLMWLDRIKKTLNVRG-----------------YP---QVQGFV
QDMRLIFQN-----HRASYKD-QDFGQMGLRLESEF-------EKTFKEV----------
------FAIEEANE----------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MLAVVQKKKSFDEIFFDYFKENKTEIAHAIPELFPFLE
SLKDRSFITDKTYADSY----EACK-N-SVPVEK-VVYKILDNLEKLFGWSFLCT-----
--LFNRTNLKAYPGLREIHKNLETELE---DKY---LSQRRKQD-----------QK---
--LATVHPRCE-QGTNLRTR----------------------------------------
-------------------------------------------------------ENWMQ
PC-------FV------K---QESLQ-------------------KLGTM----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--EDDIIGKD------------N-----L----------------------R--------
-------------------------C-LRVRI----M-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------SPGL-----------------
--------------------------------------------------QN-----AEV
P-LGD--------QVSCFLTLHS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MFQNFQ----EACR-N-LVPVQR-VMYEALDELEKKFDKTVLEA-----
--LFSKANLKAYPDLLQICNSFKNV-S---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------C--------------------------------
-------DPEASQM--------------SD-KE---EQEE--------------------
-------------------L----------------------------------------
-----------------------------PSQPLDGEEIM-------------------E
DPRS-------------G------------------------------------------
--------------------------------A---------------PISQ--------
---TM--CFFL-DTADLGNNSAVRKPKRRR----KKKGHSWTRVKAKR-RNVYR------
---------KDNSKAAGQPAPS-GKKVKMSLQDPAKIRRRRRSRP--R------------
----IRS-----------------TQNNRTPRRRAK----SRGKRKYT-YEH-VDFHSPI
IPVTCGKVKGKLHKKKLK--VGA-WVKCIQSENGDWFTPREFEIKGGRGRSKNWKLSI--
------RCGGRPLRWLMEK---TFL HN--PPRKYDRR----------RKKRGLK--SPDN
TVDSLC------------------------------------------------------
LGNSD VCETCRDGGKLFCCDTCSRSFHEDCHIPPVETEKSP----WSCTFCR MEKS----
-------SGNQQGLRES-EVLAR--LMQPEEQLKCEFLLLKVYCHSE ST----FFARIKK
RIPRSNYIKKASKNLKEPMCLDKIKKRLNEQG-----------------YS---HVEGFV
RDMRLIFQD-----HRASYEF-NDFGLMGFRLEAEF-------EKNFKEV----------
------FALRETNKDS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------TKKGKPRIH------------
------L-----------------TQKPKRDQPR--------GSRKYT-DET-VDFHSPL
LPVTCGEVNGTLHKKKFQ--KGV-LEKSIQREDGKWFTPRQFEIQGGRARSKYWKLSV--
------RCGGRPLLWLIKQ---GFL PK--PPRTCQKR----------KK-RRQE--PRDN
ALVDPC------------------------------------------------------
PENSG TCEVCQDGGKLFCCDTCWRSFHKKCHIPPVEVERAP----WSCIFCRM KDS----
-------SRS---KQES-EILER--EM LPEEQLKCQFLLLKVYSCSESS----FFAS---
-NPYRYRNRKDSQVLKERMWLNKIKKKLNEKG-----------------YH---QVKGFI
QDMRLIFQN-----HNAFYKL-KDFSQMGHRLEAEF-------ERNFKEV----------
------FAIHETNENGP-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNITYAINKPFPFFE
ALRDKSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---GNV-----VSPILVTCA---------V------
-----VLQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------DCQDSCR-N-LVPVPK-VVYHVLNELQSTFDVTLLEA-----
--LFSEVNMQEYPDLNYIYKSFEKVIQ---EKL---------------------------
--------------------------NCEGSDQEER------------------------
------------------------------------------------------------
----------------------------------------------------Q-------
------------------------------------------------------ERPNI-
Q-----------------------------------------------------------
-----LRLEQXXX--------------------------------------------X--
--X-XXXXX---------------------------------------------------
----------------------------XX------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------X-
-XXX--------------------------------------------------------
-------XXXX-XXXXXXXXXXXXXXXXXX---XQKKGHSWTRIKRKYQRNTHR------
---------ENDGKAAGQLASN-GKKVKMHLKNTAKIRGPRKYR----------------
-------------------------------------------------HEN-VNFHSPV
LPVTCGKVKGMLHKKKLK--QGV-LVKCILGDNGNWYTPREFEIRGG-GRSKNWKLNI--
------QCGGRTMRWMXXK---KCLCN--PPRIHWRK----------KK-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------MAEEM---------TSGGSYLNCRMFTV-----------DQ--
---------------------NLEDQNSEEQFFYELLFRLFRENKVEIASAVTKPFPFLM
GLRDRGFIPEQMYENFQ----EACR-N-LIPVER-VVYDVLSELEKKFDKTVLDA-----
--LFSRVNLKAYPDLLLTYRSFQNV-S---LEH--TPLQMNTVS---------WLQD---
--TPSILPYER-REISNA------CWETCGEEPQEA---SS-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------SLPRCGP--
------------------------------------------------------------
--------PAAPQM----------------TNE---EPEE--------------------
-------------------V----------------------------------------
-----------------------------PSQSLCDGKXXXXXXXXXXXX-XXXXX----
-----------------------------------------XXXXXXXXX---XXXXAEL
SKDG-------QEKCSC-VMCFSEDVPGGAEAR---------------TKNN--------
---QA--DDMM-DTVDLGSSSTLKKPKRKR---KQKKGHSWTRIKRKYQRNTHRE-----
----XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX---------------
------------------------XXXXXX---XXX----XXXXXXXX---X-XXXXXXX
XXXXXXXXXXXXXXXXXX--XXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX--
---XXXXXXXXXXXXXXXX---XXXXX--XXXXXXXX----------XXXTILK--SQDN
TLVDPC------------------------------------------------------
PGNSDLCEMCRDGGELFCCDTCSRSFHEHCHIPSVET EXXX----XXXXXXXXXXX----
-------XXXXXXXXXX-XXXXX--XX XXXXXXRCEFLLLKVYCHSESS----FFAK---
-IPYYYYMAGASRNLKEPMWLNKIKKRLNEQG-----------------YP---RVEGFV
QDMRLIFQN-----HRASYKF-NDFGLMGLRLEAEF-------EKNFKEV----------
------FAIQQTNENSS-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------MLVEDQHIDEQLLYEVVFNHFREYKVEISSAIKKTFPFLY
LLRDRKFITDKMVEDSE----ESCR-N-LIPVER-VVYNVLDKLEKTFDLTLLEV-----
--LFSDVIMKNYPDLLHVYKNFEKEVH----YK--LYLRHSDKQ---------RKEE---
--WLSSQPSLE-QGTGEDSY-----PS----LSWLY---TDPSFDL--------------
--------------GTTSPENGISE-CLYETDQKNAEGKVSTSDESDALGSQEANYNYTQ
E------SEPT------ESCLQGALQ-------------------ENNGDADR-GPPCPV
CSGKS-------------PS-KGTKHRG---REVNICEYP-----------------QT-
RFWPIKC-FCIK--------------KIGEGAEGT----S--------L------HIRGP
Q---DQIPVDPREEKGG-IVLPN---SLPIFIDN----------------QRRP----GT
SNL-DFLESNEGE---AALEATCSQPQIAPGPIDLRKTPAS-----RKSSC-RRVMGHG-
GPAE-SSEEEAPREAW--H---SAQSWGPA-EQ---DPEDIGDR---------------T
ILRKYNRK----------------------------------------------------
------------------------------------RWIALYDDSELSNG-EEPQEAFNS
PP-H------------------------------------------QSGT--------EL
LGPG-------VEKCPC-IMCAPEYVSGAQEAE---------------GGSC--------
---QA--FDKM-DTMDIGNNFALGKRR-------KKRKHMSKVRK-LLGGKL--------
-----------------------------------------KER-KRI------------
----YSVHLRKV---QKREWHQKRKRIYSAHLRKVR----KRVPRFLR-AEN-MNFHSSE
LPVACGKLKGILYKQIIK--QGV-LDKSIQSEDGKWFTPREFEIEGGYGRSKNWKISI--
------RCGGWPLQALLKK---GYLPD--PPRRRK--------------KKILT--SDNN
IINDPY------------------------------------------------------
PENANECEVCKDAGQLYCCDTCSRSFHKDCHIPSVETEREP----WSCIFCRIKDTQ---
----ERCPEFP-LCQES-EVLQR--PMLPEEKLKCEFLLLKICCCSESL----FFAN---
-RPKLW--CFCQKNTKKPVSLNLIRKRLNKNL-----------------YL---RVEKFV
QDMRLIFHN-----HRIFYQG-SNFIYLGHKLEAAF-------EKYFKEI----------
------FAIQETDNISGLE-----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------QQGQMAAGGNDLNFRIFTKNQNLELVFRHFKERKVEIASAITQPFPLLM
SLRDRAFISQQMFENCQ----EVCR-K-KLP--R-VMYDILSELEKTLDLSFLRT-----
--LFSKVNLRAYPDLIEIYKSFQNEHL-----L---FSAVLCHS---------SKEE---
--WR----GHE-GSPAHTYA----LSR----NNM--------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------RNSFSSRMSTE-----QQDPG--NFFKDILLHFKAHRVKISFAIKTPFPFFE
ILRDTELITEEMYDNFR----DSCM-N-RVPVKR-VAYRALEILENKFDLEVLRV-----
--LFSEENMKAYPDLKFIARSFENVSQ---NKL---CFHG-------------SDRG---
--YPNSQLCLE-QGPGDSCS----EES----LTLSP---SASSSSD--------------
--------------GWRNNDRRN----------T------TLIQGNQTEN-----HQSSG
F------QIDN------ESCELKL----------------------NDRHPHL-EPHSPL
PRNEE--------------R-AVLLSHG---SQTQPCSVH-----------------LV-
DIKKENS-SFSLD--------------GEQQTQARTN------------------HNQ--
--ASEIIVLSSDD-SDD-GNNSE-----EESTSI---------------ICQ--------
-----------------------------SKPLDSRE-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PHTS-RITNKR-RGTSDTDSS
STSKRYRRIRRRKR-------------------------------DRHGKYS--------
----IRN-IKMPLKINWIKAAFKRRR----------------------------------
-------------INSS-------------------------------------------
------------------------------------------------------------
-------------------------------SRRSRK----RGRRIPR-QRN-VDFNRPE
LPVTCGSATGTLYKEKYQ--QGI-HEKSIQSETGQWFTLRQFEIKGGREKSKNWRQSI--
------RCYGWTLKELIKK---KHLPN--PPRKKKEN-------------P---------
------------------------------------------------------------
------------------------------------------------------------
----------------------Q--NPQRTKKKKCELLLLSIYCNSKSR----FFIP---
-KPKKR--RENFPELREHMWLGKIKYRLNKKA-----------------YP---SVQHFV
EDMRRIFQN-----HSVIYKN-SKFNNLGVTVGSLF-------EKNFKII----------
------FSINDTSKQPQPCKHTVLLT----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANETNHLP--
-------AHSHSLQRMF-----TEDQDVDERVLCDAVFKHFKRYKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKIFNLPVLEA-----
--LFSDVNLQEYPDLIHIYESFKNETK----KG--L------------------------
------------------------------------------------------------
----------------------GEM-HPCETEEINAERKGTTSDKNGSLGSQQTNEQRAQ
K------AEPT------ESCEQVTIQ-------------------VNNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YFTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PPEVFISP---------------LRNEP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPTDYRKSSIF-----REMFR-KRVIGQDY
NFSD-SSEEEAPPEVS--S---RALRSKHG-EK---DRVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSCDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCRC-VMCFPKGVPRSQEAR---------------TESG--------
---QA--SDTM-DTMDVENKSTLEKHSGKRR---KKRKHIFKANG-LQRG----------
---------------------------------------RKKHRPRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---EVKEMINI-DEN-INFKQLE
LPVTCGEVKGTLYKKKFK--QGI-SKKCIQSEDERWFTPREFEIEGGRKASKNWKLSI--
------RCGGYTLKFLMEV---FYLSV-----FFQ--------------QRILE--SHNN
TLVDPY------------------------------------------------------
PENSNICGVCNKWGELFCCDTCPRSFHEHCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQPCHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KEGSQGPQKPMWLNKVKRNLNEQA-----------------YS---QVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVQDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------SS----------------
-----------------------EYSSEEESPDYGLIFKHFRENKVEIASAITRPFPFLM
SLRDRGYISEQKFRTCQ----QSCE-N-LIPPER-VVYDILSDLQNEFSLSLLKV-----
--IFCATHLKAYPDLKETLRNFP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------ASCSPGNS--------------------QMNDEQAE-EVPSLP
QC----------------------------------------------------------
------------------------------------------------------------
------------------S-R-G---YSPIV-------------------DCL---PRMG
E-A-LSL-----------------------------------------------------
------------------------------------------------------------
-------------------V----------------------------------------
-----------------------------PSIAKLNNK-------------------QTD
------------------------------------------THNFGTGA--------ER
STSE-------NEMCSC-VMCSPAFVPEDPEAR---------------MRSS--------
---QT--G-----SL---KDIP-------G---KRKKGHNWSRIKRRRPQAVR-------
------------------------------------------------------------
---------------------------------------------RRR-TEN-ADFSAEL
LPVTCGDAKGTLHKDRFK--QGT-SIKSIQSEAGDWYTPTEFEILGGLGRSKNWKLSV--
------RSYNWPLKLLIQR---KFLPN--SPRIYGKR----------KKQRTQD---LSS
APAN--------------------------------------------------------
SQNSDECEVCQNVGLLFCCDTCPRAFHEECHIPVVEAEKTP----WSCIFCRMQSL----
--------GSQQTHLES-EVLQR--QMVPQEQLKCEFVLLRIYCCSESS----FFSK---
-MPYYFYFRETSVGLMEPMWLDLIKKKLKGQK-----------------YS---HVKEFV
QDVRLIFQN-----HRTTFKD-LNFGEMGLRLESEF-------EKNFKEV----------
------FAIQDTNENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------RMSLE-----DQNIDNR-LFETVFRHFKRHKVQISNAIKKTFPFFE
GLHDNELITSKMYEDCQ----DSCR-N-LVPVSR-VVYNVLSELEKTFNPSLLEA-----
--VFSEVNMQEYPDLNNIYKSFEKVIQ---EKI---NYEESNGQ------------K---
--RPTIQLSLE-QEKGENKK----E-G----LTYPD---ERSKHDL--------------
--------------GMTPHENGLSD-HLSETEQMNAKMKDRTSDQNGALESQQANEQCAQ
E------SEPA------EEAYTSRVN------------------NDPNGPVTP-QIPCPF
LCSSR------------RQR-AKPSNHG---LQINSCSVH-----------------LE-
DIKKEKP-FFNSE--------------VQLQAQTRT--------------------DQ--
--VSDIIVISSEDSAES-SDGDEFPEP---STPT---------------RRRAA------
-GK-EWGEQDQGC---RNLQESCINTPIKIEPRNFRKTTTS-----RKRVW-QRVIRS-E
ESLE-SSEDEAP--WGTQS---SALRSDPD--K---DPTD---I-RNT-----------S
IRRRSNR-----------------------------------------------------
-----------------------------------KRWMSDGDSSDLSNE-GEPQATSRS
ALRNG------------------------------------------SG--------KED
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----TSVKE----MLPQ--GRS-WVKCIQSENGDWFTPREFEIRGGHGRSKNWKISV--
------RCGGRPLLWLMEK-------------------------------RGPK--SPDN
TLDNLC------------------------------------------------------
LGNSD VCETCRDGGKLFCCDTCSRSFHEDCHIPPVETEKDP----WSCTFCR MKES----
-------SGNQQGLGES-EVLAR--LMQSEEQLKCEFLLLKVYCHSEST----FFAR---
-IPYYYYMK EASKNLKEPMWLDKIKKRLNEQG-----------------YS---NVEGFV
WDMRLIFQN-----HRASFKF-NDFGQMGLRLEAEF-------EKNFKEV----------
------FALQETNEYVLMVV----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
PQNSNECEVCCTRGQLFCCDTCPRSFHEKCHIQLIDVDRNP----WSCIFCSMEIIQ---
----ERCSENQQRHQES-EVLKR--QMLHEEKLKCEFLLLKIYSCSESP----FFAS---
-KPYYS--KQAFWSQRKPMWLNKVKKKLNKKM-----------------YA---RVEGFV
RDMRLIFQN-----HRAFYKD-RKFVRLGLQLEDKF-------ENNFKNI----------
------FAIQEISKN---------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------ASAITNLFPFLM
GLRDRAISEQAFEXXXX----XXXX-X-XXXXXX-XXXXXXXXXXXXXXXXXXXX-----
--XXXXXXXXXXXXXXXXXXXXXXXXX---XXX---XXXXXX-XXXXXXXXXXXXXX---
--XXDSNICRE-TCDGGEP-----QEA----SS---------------------------
----------------CPPRNGLGLSSV--------------------------------
------------------SCERVGLQ-------------------IADGDSEAMSKLPPV
EGMSSRITV--IEDDVERES-KEMSR-----LLSYDRKVL-----------------KR-
NKMRDRE-GLSTA--------------LEK--QKGKNRGDS----------RHGERNQ--
--DKEKY-QRISAA-------------KHRGTCA---------------HRA-P----QM
TDEVEQMEISRRL---PSE-----------------------------G--EERSDECLE
VCDEGEAQEVSHPR----------AGAVPC-FS------------PVT-----------S
DSNPPQKRNRVKPEQVSRTRPFRG----E-------------------------ERS---
------------------------------DECL----E-VCDEGEA--------QEVS-
HPRPG------------------------------------------AX--------XXX
XXXXX--------XXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX--XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX---XXXXXXXX-------
--------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXX----XXXXXXX-XXX-XXXXXXX
XXXXXXXXXXXXXXXXXX--XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
------XXXXXXXXXXXXX---XXXXX--XXXXXXXX-------------XXXX--XX-X
XXXXXX------------------------------------------------------
QENSDTCEVCQTKEDLFCCDTCLNSFHKDCHIPPVDPERNP----WSCIICMIEVSS---
-------VS-QQCHQES-EILER--LMLPEEQLKCEFLLLKVYCNLESS----FINI---
-I-HDY--NNQGDSQRIKEQIQKIKKRLSEKV-----------------YQ---RVEGFV
RDMCLFFKK-----------N-NDFDQMGLTVEAEF-------EKNFKEV----------
------FAIQETNESNS-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ASGGSDLSCRTFTG-----------YQ--
---------------------NPEEQSSDEQFFNELIFRFFRENKVDISSVITQPFPFLM
GLRDRSFIPEQMYEHFL----EACR-N-LVPVER-VMYDVLSELEKKFDRTVLEA-----
--LFSSINLKAYPDLHQIFRDFKKMIL---ENF---NYQITNEG---------ETKD---
--MINLQ-----------------------------------------------------
--------------------LGREQ-VPLERASLQMNNIR--------------GLEDTP
R------LQPRD---RQGVSNAL-------------------------------------
----------------------------------------------------------L-
E-----------------------TSAGEQ-----------------------TLETLRS
P-QRYWPVSCNPAALPR-GKRGK---SEETL-------------------GWLPYNKE--
-------VT------------------C--------------------------------
-------DSKAPQI--------------TH-QG---ESKE--------------------
-------------------G----------------------------------------
-----------------------------LSLSPAKGVEDSSTCWETCNE-EEPQEASNS
PPRH-------------GPVSDKPEDFQMNTEGDLEEFASSPLSSKGQGA--------EL
PANG-------SEKCSC-VMCFSKDVPVDPEAR---------------NQA---------
-------SGVM-ALVDSRNTSTLGKLKRKR---RKKKRHSWTKIKGGKWRNSYQK-----
----QKQRDPDNSTAAGQLVVK-RKRVKMHLEDPAKIKGKKRARP--K------------
----LYF-----------------TQSDRATQKRVK----KRGSRKYR-GNN-VDFQAQI
LPVTCGEVKGRLHKKKLK--KGV-SMKCIKGKNGEWFTPREFEVHGGYTRAKNWKLSI--
------RCGGRNLRWLIEK---GY LLK--PPRKYPRK----------R-KMIPK--SHDN
TLVDPY------------------------------------------------------
LGNSD VCEVCRREGKLFCCDTCSRSFHEDCHIPPVETERTP----WSCTFCS MKEI----
-------SESQPCLRES-EVLAR--QMWPEEQLK CEFLLLKVYCHSESS----FFAK---
-IPYYYYIKELSENLKEPMWLDRIKKRLYERR-----------------YR---RVEGFV
QDMRLIFQN-----HRASYKF-RDFGLMGLRLEAEF-------EKNIKEV----------
------FAIQETNESSSPA-----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MLAVIQKEKSFNEIFSNYFKENKTEIAHAIPKLFPFLE
SLKDRSFITDKIYAHSY----EAYR-N-LVPVEN-VVYNVLDHLEKLPDWSFLCT-----
--LFNRTNLDAYPGLREIHKSLETELQ---DKY---LSQRSKHD-----------QK---
--LATIQPRYE-QGTNLHTH----------------------------------------
-------------------------------------------------------ENWTG
PC-------FV------K---QENLQ-------------------KPGTV----------
------------------------------------------------------------
-------------------------------------------------------KNQ--
--EDEVIVISSEGSECS-DEDDE-----K----------------------E--------
-------------------------L-LEVFA----L-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------TPGIRRQIEEE-GE-------
-D------------------------------------------------HN-----SEL
P-SGT--------HASCFLTHHP-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNIAYAINKPFPFFE
ALRDKSFITERMYKESL----EACL-N-LVPLSK-VVYNILSSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---VGY-----TYEEKNRPP---------L------
-----TLLEDL-ANPAEGC---------SLQTLLPPPRPQISLPSHLSSAPRVCDPRATT
-------QPIIEILDEQPSPSPRA------------------------------------
----------------------VPLPGCIQEGKTTPVSSRDH--QRKDKEDSR-EMPHSP
SGPES------------------VVK----------------------------------
------------------------------------------------------------
-----------D------------------------------------------------
----DSPAANDLE---MAQEVPCTPANK--------------------------------
----------------------------------------KARR-KKH-----------P
NWSNSKRRQQKKKPRQ------------------------DEMMAGVASPGHGVQEKLKA
VSRRTLWKDDSST---NVKEVTKTQRARMRHAQTSNSQEISKEASKTSGR-KR----PST
ARRT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------TQVPEKTK-NDA-VDF-TPT
LPVTCGKAKGTLFQEKLK--QG-ASKKCIQNEAGDWLTVKEFLNEGRRATSKAWKGVI--
------CCNGATLRHLEQK---GLLFC--TSKSKPQK---------------K-------
-----------------------------------------------------------G
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MLIFKRFRENKVEIASAITKPFPFLM
SLWDLAFISEQMYKHFQ----ETCR-N-LVPVTR-VVYEVLHELEKTFTSSLLQV-----
--LFSKANLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------NLYKEKLK--QGS-SEKCIQSEDGRWFTPREFEVEGGCAKFKNWKQSI--
------RCGGYPLKHLIER---R----------------------------I LK--SHNN
TIADPY------------------------------------------------------
QKNSN ICKVCRKWGKLFCCDTCTRSFHKNCHIPPVEPERDP----WSCIFCE MKAIQ---
----ERCPESPPRHQES-EVLMR--QMLSEEQLKCEFVLLKVYCDAKSL----SFES---
-EPYHQ--RGRSQGP EKPMWLNKVKETLNEKM-----------------YL---QVKGFV
EDMRLIFQN-----HKVFYRD-KKSIRLGLQVENTF-------EKNFKKI----------
------FAIQGTSSFKTFVLFV--------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRRLNGGVSRVANEMNHLP--
-------AHSQSLQRM-----FTEDQDVDERLLCDAVFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEVNMQEYPDLIHIHKSFNNAIQ----DK--LFFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------ERKERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQEEVPESPEAK---------------MEND--------
---QA--CGKM-DTVDIGNNSTLGKPKRKR---KKKKGHSWTRIKTRTQKKIQQ------
---------HDNSKGGG-QLVPKEEKAKVNLQGLSKISGSKRSKPGT-------------
----RF------------------AHSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGS-FLKCIQSEDGNWFTPAEFETKGGYARSKNWKLSV--
------RCGGWPLQRLMKE---GSLPN--PPKIHYR-----------NKKRILK--SHNN
SSEDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETEKTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCQQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFI
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------IYEDSQ----DSCR-N-LVPVPR-VVYGVLSEVEKTFDLSLLET-----
--LFSDVIMKSYPALNRIFESFKAVIQQGTCQE--SDEKER-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------KENLNTP---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----K--SLEQ-GTVNLGKNSTLGKSKGKR---RL-------------------------
------------------------------------------------------------
--------------------------------------------KVNT-NES-VNFQSEI
LPVTCGTVKGILYKNKLK--QGA-IVKSIQSEDGNWFTPREFEVKGGYEKSSNWKLSV--
------RCGGKTLKKLMEV---GFL PN--PPRLYNRK----------KK-----------
------------------------------------------------------------
QRNSD VCEVCHDGGKLFCCDTCSRSFHEDCHLPPVETKRSP----WSCIFCRMKPY----
-------LGCQKCHRES-EVLTR--QMGPEEQLKCEFLLVNVYCHSVMN----VFEK---
-IPHDNYXXXXXXXXXXXXXXXXXXXXXXXXX-----------------XX---XXX---
--XXXXXXXXXXXXXXXXXXC-SDFVLMKIRLEKEF-------EKNFKEV----------
------FAIWETNEKS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TDLAEGS---------SLRTPLALPPPQSPQPSSSPCAPRVSEPGTSS
-------QQSNEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEDDSE-EMPSLL
ASTVP------------------VASDD-----------------------------LIS
QIKDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------S
VWSTPKRRHKKKSLPRGWK------------------------QLMQASPRHGIQKKLKV
VDQVPQKKDDSTW---NSTVVTRVQKARAECARNSRSEEISDDTSKMNEG-KRSQKTPST
PSRLTKLFTNL-FG----PMA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGHGIKE------KLQVVDKVTGW
I---------DDSTWN--------SEVMMSIQKAR-TECAQKSRSKE-------------
----------------KKKE-KDIC------------------SRKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWFTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLAELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRELNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------TS
TNLD--SLESSEGREAQ-EATSQ---PQVSXXXXXXXXXXXXXXXXXXXIDSSADEA---
T-L-GAYSSALGC---DPDDEDSSDF------EN---------------------TFIYG
ISN---------------------------------------------------------
------------------------------------------------------------
-------------------------------RKRRFSGVDTSELNN--------------
--------------------------EEP---------REASSSVLRNGS--------GA
ELQG-------LEKCSC-IMCFSKSVPRGQEAG---------------TEGS--------
---QASHMMXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKRGRRRVQT------
-----------------------------LSNRAPKKRGKPRGRKTVN------------
------F-----------------GP-LK----RGR----RRGSKIPR-EAN-MDFRLPE
LPVTCGEVEGILNKEKMK--KGV-SEKCVQSKDGRRFTLREFEVEGKRAASKNWKMSV--
------RCGGWPLKYLIEX---XXX XX--XXXXXXX---------------XXX--XXXX
XXXXXX------------------------------------------------------
XENLN ECEVCHGKGALFSCDTCSRIFHDKCHIQPKDAGTNP----WSCNFCKI KALQ---
----ERYSESQPCHQES-EVLKR--KM LPEEQLKCEFLLLKLYCSPRXX----XXXX---
-XXXXS---REASRPKKPMWLNKLKKKLRKYT-----------------YC---QVEGFV
QDMCLVFQN-----HRQYSSDKEKFIRLGLHLEARS-------ENDFTDI----------
------FAIQEISTNSTQFE----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKRMYMESL----EACR-N-LIPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGA-----SYERQSRGT---------P------
-----ILLEAP-TGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTSVTNDKLTSKMNEEEDSE-EMPSLL
ASTVQ------------------VASDN-----------------------------LIP
QIKDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDPE---EPQEVPSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKRRHKKKSLPRG-----------------------------TASPRHGIQKKLKR
VDQVPQKKDDSTW---NSTVVTRAQKTRTECVRKSRSEEIIDGTSEMNEG-KRSQKTPST
PRRDT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------TSPGHGIQE------KLQMEDKVTQR
K---------DDSTWN--------SKVMMRVQKAR-TECARKSRSKE-------------
----------------KRKE-KDICSSSKR--RFQK---NIHQRGKPE-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTPNEFEIEGKGRNAKNWKRNI--
------RCGGTTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCQGGQLLRCGTCPRVFHEDCHIPPVEAKRTL----WSCTFCRMKRS----
-------SGSQQCHHVS-KILER--QMQPQDQLKCEFLLLKVYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLIFRN-----HKTFYKA-SDFGRVGLDLEAEF-------EKDLKDV----------
------LGFHEANGGGFWTFP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------VQ--
---------------------NVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVAR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--SIHRMNNVN---------ELED---
--RPRLLPYGK--QENSNAC----HETGDVAVPQEA---LSS------------------
---------------SPRCEPGFS------------------------------------
------------------SCKLAIQ---------------------IDEEESE-EMPKLL
PYDTE------------V---LE-SNGM---IDAARTYST--APGKKEGDKEGRNSPG--
-----------------------------KRN-------------------QDKEKYQDS
PA-GKDREIFDLKTPQV-TNEGE---PEKGL-------------------SLLPGEGE--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------MSSELEDRPMNEEGESEELASSLLHDDVPGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGSPEAR---------------MGSD--------
---QA--CGTM-DTVDIGNNSTLGKPKRQR---RKKRGHGWSRMRTRRQKNSQQ------
---------NDNSKADGQLVSGE-KKANVNLKGLSKIRRRKRGKPGTR------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-MDFKAPL
LPVTCGGVNGILHKKKLK--QGI-LVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GFL HD--PPRIHYR-----------KIK----------
------------------------------------------------------------
MRNLDE CEVCRDGGELFCCDNCSRVFHEDCHIPPVEAERTP----WSCIFC RMNKS----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYI REACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQNKWEQLTGLVDAESIQQMAP------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------NGGGA------------------------
---------EREGDTES-----ETDQSIDDRLIYETVFKHFKRHKVEISNAIKKTFPFLE
CLRDRELITNKMYEVSD----VCYV-T-IW------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMYQKLRIAYAIDKPFPFFE
GLRDNSFITQRMYMESL----EACR-N-LVPVSK-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFRR---VGEQQSRASYEQQSRDT---------P------
-----IPLEAP-AGLAGGS---------SLPTLLPLPQPQPPQPSCSSCAPRVSEPGTSS
-------QQSKEILSESPSPSDPT------------------------------------
----------------------LPLPGLIQEGRNTPVTNDKLTPKMNEEEDSK-EMPSLL
TGTVQ------------------VPSDN-----------------------------LIP
QVKDKEG------------------------LQEMP-------------------HS-PS
GPMP----EIRD------------------------------------------------
----DSLEPNDPE---EPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-SKR-----------C
IWSTPKKRHKKKSLPRG-----------------------------TASPGRGIEKKLKV
VDRVPPKKDDSTW---KSTVMTRAQKARTQRARKSRSEEITDGTSKMKEG-KRNQETPST
PSRVK-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------TSPGHDMQE------KLQVVDKETQR
K---------DDSTRN--------SKVMMRVQKAR-IKCTQKSRPEE-------------
----------------KKRE-KDICSSSKR--RFQK---NIHQRKKPK-SDT-VDFQWSE
LSVTCGVAKGILYKAKMK--HG-SSTKCIQNEKGAWLTPKEFEIEGKGRDTKDWKRSI--
------HCGGKPLLELLR------------------------------------------
-----------------------------------------------------------K
--NLDECKVCCKVGQLLCCSTCPRAFHEDCHIPPVEAKRTP----WMCTFCRMKRS----
-------SRSQQGHRVC-KILER--RMQPQEQLKCEFLLLKAYCHPQSS----FFAA---
-IPLNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLIFRN-----RKTFYKA-SDFGQVGLDLEAEF-------EKDLKDV----------
------FGFHEANDSSFRTLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNIAYAINKPFPFFE
ALRDNSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---VGY-----TYEEKNRPP---------L------
-----TLLEDL-ANPAEGC---------SLQTLLPPPRPQISLPSHLSSAPRVCDPRATA
-------QPIIEILDEQPSPSPRA------------------------------------
----------------------VPLLGCIQEGKTTPVSSRDH--QRKDKEDSR-EMPHSP
SGPES------------------VVK----------------------------------
------------------------------------------------------------
-----------D------------------------------------------------
----DSPAANDLE---MAREVPCTPANK--------------------------------
----------------------------------------KARR-KKR-----------P
NWSNSKRRRQKKKPRQ------------------------DEMM-GVASPGHGVQEKLKA
VSRRTLWKDDSST---NVKEVTKTQRTRMRRAQTSNSQEISKEASKTSGR-KR----PST
ARRT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------TQVPEKTK-NDA-VDF-SPT
LPVTCGKAKGTLFQEKLK--QG-ASKKCIQNEAGDWLTVKEFLNEGGRATSKDWKGVI--
------RCNGETLRHLEQK---GLLFF--TSKSKPQK---------------K-------
-----------------------------------------------------------G
A-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANETNHLP--
-------AHSHGLQRMF-----TEDQDVDERLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKIFSLPVLEA-----
--LFSDVNLQEYPDLIHIYESFKNETK----KG--L------------------------
------------------------------------------------------------
----------------------GEM-HPCETEEINEERKGTTSDKNGSLGSQQTNEQRAQ
K------AEPT------ESCEQVAIQ-------------------VNNGDAGR-ETPCPL
PCDGE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YFTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDIDE---PPEVFISP---------------LRNEP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPTDYRKSSIF-----RETFR-KRVIGQDH
NFSD-SSEEEVRPEVS--S---GALRSKHG-EK---DRVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCTC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDTM-DTMDVENNSTLEKHSGKRR---KKRKHVFKANG-LQRG----------
---------------------------------------RKKHRPRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RG-PRIPR-DEN-INFKQLE
LPVTCGEAKGTLYKKKFK--QGI-SKKCIQSEDKRWFTPREFEIEGGRKASKNWKLSI--
------RCGGYTLKFLMES---F---C-----FFQ--------------QRILE--SHNN
TLVDPY------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQPCHQES-EVLMR--QMLPEEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KEGSQGPQKPMWLNKVKRNLNEQA-----------------YS---QVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVQDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------S
L------FYGTFFPRTF-----TDVQDTEDP--VQIVFKYFKTNKVRISYAIQKSFPFLE
GLRDRELITNKMYDDYQ----ESCK-H-LVPVHK-VMYNVLNELEKKFDLAVLDA-----
--LFSEVNRAEYPDLIHIYKDFQNSS----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFAAVQKKEISFEIFVNHFKENKVEIANAITKPFPFLE
SLRDNSFITEKMYADSQ----EACI-N-LIPVQR-VVYHVLCHLEKVFDCSVLSV-----
--LFSRVNLKEYPDLIEIHKSFKKA------LP---FSQKRDGK---------KTPK---
--MPSFQPSCK-QGVIHS----------------G----TRTETSE--------------
--------------PVRDVKSTY----------IK----PEHSILGPGDAL--GTQQANT
ST-------QV------ETRELKDLQ-------------------IKKERGSE-EMPSGR
PH----------------------------------------------------------
------------------------------------------------------------
----GRQVISSEDSDSC-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------EG-EETLEASSS
ASMPR------------------------------------------PG-----------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------ISTE-----DQDIEDKCIDNCVFNHFKKLKVDISYAITRIFPFLE
RLRDHEVITNKLYEDSQ----ESFR-N---LLQK-VVYNVLNELEKTFNPEVLKE-----
--VFSEANMMEYPGLIPIYESFRNVVP---DQS---YLQESDEE---------ARME---
--GPSSQLSLE-QGTDESSI----P-S----LTPSH---SDSPIST--------------
--------------GTIPPENGLLE-QFCETQQVKRRRKGETRDKNDALGSQEANQQCAQ
K------PEPA------ESCEPV----------------------VNNGDAEN-ETPRPA
RCDEQKF----------GPG-AEVPNQG---IPIKPCVVS-----------------LV-
DIKKEKT-FFNSD--------------VEQQDQARTN------------------HKQ--
--ESDMIDISSEDTEES-SDEDK--------HSA---------------MESIP----VT
SNY-DSSESNEGE---DIQEATCSRSQTAPGEDLDAKPWPE-----FKHLWLKRVGCQ-P
HMLEVTHSNPAP--ANANV---GGLENKRH-NT---QIPHTQML-TAF-----------S
RFEPSQT-----------------------------------------------------
-----------------------------------ERR-KNNDFQDTNQN-LSQKHENKS
TLFPG------------------------------------------IK--------VDP
VAHT-DY-----KRHPG-IPCTPISYPHNLMIPK----------QLSTASPT--------
---QS--LFFSENKKFLGYLGKLSKFNGKAR--RSSQ----K---SSAITCLE-------
--------------------------------RLR-----KRGRPRIN------------
----VPLSDRGPGK---RYQKTGKKKNIKRIKPQRKL----RISRFPR-DEN-INFQLPE
LPVTCGDLKGTLHKKKLK--QGS-PQKSIQTENGRWLTPREFEIKGGYEQSKKWKHSI--
------RCGRYRLQDLMEK---GVLPN--PPKPKRKV-------------II--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------MDPKLEKQLLIKFREKKLAISDAVNKLFPFIY
SLRDQALISNRMLQHYK----NE-----SVPMKE-RIYNVLEKLEKNFNKKVLKV-----
--LFSRNNVKEYPDLKRIRRTFEDVLS---EDS---SPERSDSE----------------
-----------------R------------------------------------------
------------------------------------------------------------
---------PA------KI---SNVR-------------------SSPQDTRR-------
------------------------------------------------------------
---VENP-LLRRK-----------------------K-----------------------
--LRKTLLINS-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
IRRRG------------------------------------------LR-----------
----KQN------------------------LR-----------------T---------
-------------T----------------------------------------------
------------------------------------------------------------
-------------------------------LKRPTL---RKSARQSQ-SQS-VDFRSPQ
LPVTCSKASGTLYQEKMK--KGS-LEKCIMDANGNWLTLREFEIKGKREHFKNWRKEH--
-------FLWWAYAGMATE---GAINS--QASNTIQ----------------EK--EEGG
TEEVAF------------------------------------------------------
EGVPETCSWGRKGGI----GSNSR------------------------------------
----------------------P--PSLPETPRRCKLLSGNMWRGRGKLIQESLRLR---
-KSGKM--HPNGQALVHPRGISELS-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------FVL---CSVSLICKLLQPPQ-TSQNLDDH
F------HMVSFFPRMF-----TEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLE
GLRDRDLITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSDVNMQEYPDLIHIYKGFENVIH----DK--LPLQESEEE---------EREE---
--RSGLQLSLE-QGTGENSF-----RS----LTWPP---SGSPSHA--------------
--------------GTTPPENGLSE-HPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQ
K------AEPT------ESCEQVAVQ-------------------VNNGDAER-EMPCPL
PCDEE------------SP-EAELHNHG---IQINSCSVR-----------------L--
------P-FSIS--------------KVECQAQAR----T--------H------HNQ-A
S---DIIVISSEDSEGS-TDVDE---PLEVFISA---------------PRSEP----VI
NND-NPLESNDEK---EGQEATCSRPQIVPEYYSDLVPLSYIETSKGHLLL-SAVIGQDH
DFSE-SSEEEAPAEAS--S---GALRSKHG-EK---GKNSSLDFRALT-----------S
EHLFPDHTQ---------------------------------------------------
-------------------------------------QLSRSQFSASTSS-GEWAQ-IKM
FTNH------------------------------------------NLGS--------QP
QEPE-------NKKCSC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR-----------------------------
---------------------------------------RKKDRPRKH------------
----LTLNNKVQKK---RWQQRGRKAN-IRPLKRRRK---RD-PRIPK-DEN-INFKQSE
LPVTCGEVKGTLYKERFK--QGT-SKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSI--
------RCGGYTLKVLME--------------------------------RILE--SHNN
TLVDPC------------------------------------------------------
PENSNICEVCNKWGRLFCCDTCPRSFHERCHIPPVEANKNP----WSCIFCRIKTIQ---
---ERC-PESQSGHQES-EVLTR--QMLPEEQLKCEFLLLKVYCDSKSC----FFAS---
-EPYYN--REGSQGPQKPMWLNKVKRSLNEQM-----------------YT---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFTRLGIQVQDIF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMITD-----------IQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNVS---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DVEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYSA--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRENLDLKTPQI-TNEGE---PEKGL-------------------CLPDEGEAEG
S-G-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGE----------------------
-------------------VSSELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGCPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKSVQQ------
---------NENSKADGQVVSNE-KKANVNLKGLSKTRGRKRGKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDLKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GF LPH--SPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVETERTP----WSCIFCR MKES----
-------SGSQQSCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYI RETCQGLKEPMWLDKIKKKLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MVSFLPRMS-----LENQNIDNRLFFETVFRHFKRHKVQISSAIKKTFPFFE
GLRDNELITSKMYEDCQ----DSCR-N-LVPVPR-VVYNVLSELEKTFNPSLLEA-----
--LFSEVNMQEYPDLNHIYKSFENGNY----LI--ICLLMFKVN---------FGQQVYN
ELPSHVIIS--------A-------------EQWGY---NR-------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFGVIQKKEHFNEVFLNYFKENKVEIAHAITKLFPFLE
SLRDRSFITDKIYADSY----EACG-N-SIPVEK-VVYNVLSHLEKLPDPSFLWV-----
--LFNRVNLKEYPALREIYKSLETELQ---DRY---SPQRRKQE---------E-QK---
--LATMQPSYE-QGTNLHTH----------------------------------------
-------------------------------------------------------ENWAT
----------------------ENLQ-------------------EPETP----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--VDEIIAISSESSECS-EEK---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
S------SSGDLMTKISTD-----DQTIVKKLVYDATFRHYQKYKVEISYAIDKTFPFLE
GLRDRGFISHKLFEDSE----ESCK-N-LVPVQR-VVYNVLSELEKTFNLPLLQA-----
--VFSKVNMKQYPDLIHIFKSFKKAIR---NQF---HPQALGE------------EG---
--RFNLQPSLE-QGTGVDF-----HQS----LPWPRV--DSSPSI---------------
--------------DRTPPANGLSE-HFCEAEQINAERKDLTSDKNDASGSQQISQRCTQ
E------SEPG----------------GYSEQA---------VLQMNNGDSRQ-EVSSPL
SS----------------DE-ENPGTEQ---LIMXXXXXX-----------------XX-
XXXXXXXXXX------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--
--XXXXXXXXXXXXXXX-X-XX---XXXXXXNS---------------------------
------LELSDED---KSQQTTCSQYLMPTXXXXXXXXXXX-----XXXXX-XXXXXX-X
XXXX-XXXXXXX--X---------------------------------------------
-----------------------------------------XXXXXXXXXXXXXXXXXXX
XX----XXXXXXX---XXXX-----------------XXXXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXX-------------------------------XXXXXXX--------
--X-X--------XXXX--XXXXXXXXXXXXXX---------------XXXX--------
---XX--XXXX--XXXX----XXXXX-XXXX--X-------------XXXXXXX------
--------------------------------XXXXXXXXXXXXXXXX------------
----XXXXXXXXXX---XXXXXXXKRVNTEVLKMRRK---SMXXXXXX-XXX-XXXXXXX
XXXXXXXXXXXXXXXXXX--XXS-STKCIQSEDGRWFTPREFEIEGNHERSKNWKLSV--
------RCGGETLRWLIEX-XXX XXXX--XXXXXKKS-------------LKV----PND
VIADPY------------------------------------------------------
PENSN ICAVCRKGGYLFCCDSCPKSFHEDCHIQLVDPERDP----WYCIFCEIKAIQ---
----ERYPGKQPCHQE---IPKR--QMLPEEQMKCEFLLLKVYCWEKSA----YFAN---
-EPHYS--S---QLSKESMWLNKIKKRL---R-----------------EKYYHHVAGFX
XXXXXXXXX-----XXXXXXG-HDFAMLGYQLEAVF-------TENFREI----------
------FAIQKTKSESSLQFH---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
T------EGGSFSNRMSTG-----HENTE------SIFRLFRVLKLDISDAIKDLFPFLE
VLRDNNVISDKQYDDFQ----ESHG-N-LIPVQK-VVYKVLKELEEKNDLEALGL-----
--LFCKQNMKAYPDLERILKRFKNVLP---QSQ--FWSEE-------------IDRR---
--DQNSQLSVE-QGPGDSCS----QES----LTWSP---SDPSSSN--------------
--------------GWRST------------------------QGTQTEN-----RQFSI
P------QIHS------ESCELKV-Q-------------------LSDRDAGQ-EPHIPL
PCSNK--------------R-AAIPSHG---I---HCSVP-----------------ME-
NIKQENS-SFFLD--------------DEHQTHARTD------------------NNQ--
--ASEIIDLTRDN-SDD-GPRCS-----EESTSV---------------TGQ--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------SREKT-------------------------------DRIGKYI--------
----IRY-FKMPMDTSWKKAYT-RRR----------------------------------
-------------INSS-------------------------------------------
------------------------------------------------------------
-------------------------------SQRRRK----RGPRIPK-QKN-VDFNIPE
LPVTCGSAKGTLYREKFK--KGI-YEKSIRSETGCWLTPKEFEIEGDREDSKNWRQSL--
------RCCGWTLGELIKK---ELLPN--PQRKKKK------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDR---------------------------------------------------EG
S-G-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCPLPDEGE----------------------
-------------------VSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKNVQQ------
---------HENSKADGQVVSNE-KKANVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKYK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SYNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREMCQGLKEPMWLDKIKKKLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNDNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKRFKENKVEIASAITKPFPFLM
SLRDRGFLSEQKFQVSL----GSCQ-N-LIPVER-VVYDILSDLQNNFSLALLEV-----
--IFSPTHLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRRLNGVVSRVANEMNYLP--
-------AHSQSLQRI-----FTEDQDVDEGLLYDTIFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEVNMQEYPDLIHIRKSFNNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQEEVPESPEAK---------------MENG--------
---QA--CGKM-DTVGIGNNSTLEKPKRKR---KKKKGHSWTRIKSGTQKKIQQ------
---------HDNSKPGG-QLVPNEEKAKVNLQGLSKISGSKRSKPGT-------------
----RF------------------TQSDRAPQKRVR----SRASRKHK-DET-VGFQAPL
LPVTCGGVKGILHKEKLK--QGS-FLKCIQTEDGNWFTPGEFETKGGYARAKNWKLSV--
------RCGGRPLQRLIEE---GSLPN--PPKIHYR-----------NQKRILK--SHNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFI
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------MGLEPWKM----------FTLSSALEKALLQHFILYKLEIAYAINKPFPFFE
SLRDKSFITEGTYRESL----EACR-N-LVPTSR-VVYNILTKLENTFNLSLLMT-----
--LFSQINLCEYPNLRMILRSFIN---VST-----SYREPSGAT---------P------
-----TPLRAP-ADPAEGS---------SLQTLLQRPQPQPPPPRHLCL--IVGETTAPL
-------QQIHESLDKPPSPSGPA------------------------------------
----------------------VPLPGLVLGEGSTPVANGNLTSNTKE------------
------------------------------------------------------------
-----ED------------------------ARERP-------------------RL-PT
GTVQ----VIQD------------------------------------------------
----ASSEPSDPK---EPQETPSTSPKK--------------------------------
----------------------------------------KGQK-RKR-----------C
IWSSPRKRYKRKSLPRG-----------------------------AASPGRGGQEKVQV
VD---QRKDDPAW---NSRVVKRTQRTRTKCAQTSSS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------KEKAK-EDT-VDFLAPT
LPVICGEAKGILYKEKLE--RGGASEKSIQNEKGAWVSPKEFTIEGKMERSKCWRRSV--
------RCGGKSLRELIEN-----------------------------------------
------------------------------------------------------------
--------------GILLCPPGRNLKSKVPSS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGYNELSSRTIP----------------
-----------------------EDQNEEESDDYQLMFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LVPVER-VVYDILSNVQKKFSRDLLKV-----
--IFSKTHLKAYPDLKETLKHFFLNAS----KT--ND-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------E--------------------
-------------------Q----------------------------------------
-----------------------------AEEMQCNGGEGSNSCEQTRQTRQEPQDDLPS
------------------------------------------SLRQEAGA---------Q
QPTR-------EKKCSC-VICSPTYVPEDLEAR---------------MGSS--------
---QG--E-----CVGTRRNIPARKPKKQR---RKKKGHNWSKPRWRKPMSVQR------
---------KRL------------------------------------------------
--------------------------------------------RRRR-KEN-ANFSAEL
LPVTCGNLKGVLHKEKFK--QGI-SVKSIQCQNGNWFTPSEFEMMGGYGKSKNWKLSL--
------RCHNWPLKLLIQR---NFLPN--PPRIHRKR----------KEQRTQN---LHR
SPADPS------------------------------------------------------
IQNSDKCEVCRDGGLLFCCDTCFRAFHEDCHIPTVEAEITP----WSCIFCRMQSL----
--------GSQPSLPES-EILQR--EMAPQEQLKCEYVLLRVYCCSESS----FFSK---
-MPYYYYFREMTVSVQEPMWLDIIKKKLSDQA-----------------YC---QVEDFV
QDMRLIFRN-----HKITFKD-PKFGEMGFRLESKF-------EKSFKEV----------
------FAIQETNEKS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
A------GAQDLSTRMV-----TDVQDGGDP--MKILLKCFKRHKVPISYAINKSFPFLE
GLRDRELITNKMYEDCQ----ESCK-N-LVPLQR-VMYNVLNELEKIFDMDVLEA-----
--LFSEVNREEYPDLMSIYKDFQNEIH----NK--LYLQESDGE---------EREE---
--RPKTQLRLE-EGTGRNSA----SWR----LTWPC---SEPSSSN--------------
--------------GTTSPEKELPD-YPLEREQINGLRTQTTRENNGSSGSHQTDEQADQ
E------SAPV------ESFEEGGVP-------------------VSNGDAST-EPPSPL
PCDEE------------K---AEMQSQG---AKVNPCSVL-----------------LT-
DIKKEKP-FYS---------------ENEQRAHAR----A--------R------SNQ-A
S---DIIVISSDDSGEL-SDEDK---APGASTSA---------------LRSDS----EI
SHY-GPLESTEEK---ETQEATCSD-QIKPKPKNFRGSSTF-----RKNLL-KRGREHVY
DSSE-SSEEETLPKIRFWS---SGRRSGLS-TT---G-----------------------
------------------------------------------------------------
--------------------------------------LSNSDSAKLNHR-EEHAE----
ALRS------------------------------------------GSGA--------EP
QGPG-------N-KCSC-VMCPSECVPGGQEAR---------------MENG--------
---HT--SHIR-DAVDVGNDSTLGKGIGKRR---R-------------------------
----------------------------------------KRGRSRSL------------
----STLRTGTPRK---RGWPKERKRINSMPLRRGR----KRGPRIPR-EAH-VNFHVPE
LLVTCGNARGTLIKEVFK--QGV-WKKSIRGEDGRWFTPREFEVEGNYAPSKNWKLSV--
------RCHGWTLRELIQK---GALPE--PPSKKPKQ-------------KTPA--SHMD
SPVDPY------------------------------------------------------
PENSNECEVCSQGGQIYCCDTCPRSYHENCHVPPVETDRDP----WSCIFCKTKAIR---
----KRCREVQPCHQES-EVLMK--KMDDEEQLKCELLLLKVYHYAESA----FSFA---
-TQDYT--NGATVGQQEHMHLNEIKTKLSEKK-----------------YL---RVREFV
QDMHLIFEN-----HTAHYRD-TNFSRQGLNVKARF-------EKNFKNI----------
------FGVQETTPNNR-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------PLLYFSSRTV-----PDAQDAEDP--MKIVLRCFRERKVLISYAIKKSFPFLE
ALRDRELITNKMYEDCQ----ESFK-S-LIPVSQ-VIYKVLNELEKKFDMEVLEA-----
--LFSEINRMEYPDLMNVYKDFQNGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------ADGGGDLSTRSLNECISPIANVTNHFP--
-------THSHGLQRMF-----TEDQDVDERLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIQ----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGTGENSF-----QS----LTWPR---WDSPSHD--------------
--------------GTTPPENGLSE-HPCETEEINADRKDTASDKNGSLGSQQTNEQSAQ
K------TEPT------ESCEQVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-YCTS--------------NAECQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PLEVFISP---------------VRSKP----VI
NND-NSLESNEEK---EGQEATCSRPQTVPEPMDSRKSSIF-----REKFR-KRVIGQDC
NFSD-SSEEEALPEVL--S---RALRSKHG-EK---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RLSSSDFSELSNG-EELQETCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TENS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGRKTN-KRPLKRRRK---RG-PRIPR-DKN-INFKQPA
LPVTCGDVKGTLYKERFK--QGI-SKKCIRSEDRRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLME--------------------------------RILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEADKNP----WSCIFCRIKTIQ---
---ERC-PESQPWHQES-EVLMR--QMLPEEQLKCEFLLLKVYSDPKSP----FFAS---
-EPYYN--KERSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFHN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMVTD-----------IQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNVN---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DAEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGP-------------------CLPDEGE-EG
S-G-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGSDDCSQMCDG-EEPQEVSSS
LARC-------------GSVSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRTQKNVQQ------
---------HENSKADGQVVSNE-KKANVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------AACGWA------N---GFLPN--PPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREMSQGLKEPMWLDKIKKKLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------VITVAMEKALLQHFICRKLEISYAIQKPFPFFE
GLRDKSFITEKMYKESL----EACT-N-LVPVSR-VVYNTLTQLEKTFNLSLLLT-----
--LFSQINLREYPNLTEIFGSFRS---GNV-----ILFALEGLL---------C------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTVPRALEEALFQHFIYQKMEIAYAIHKPFPFLE
SLRDKSFITNRMYKESL----EACS-N-LVPISR-VVHNILTKLEKTFSLPLLVT-----
--LFSEINLREYPNLKTIFKSFKI----TN-----SYGQWSRAT---------P------
-----SLLEVP-PGPAEGR---------SLQPLPLLPPPPPPPRSCPHCVSRGSEPGASS
-------QQSHETPGGPPSSSDPA------------------------------------
----------------------VSLPGLMQEGRRTAVTHDNLTSKMNEQEDSR-KMPSPA
PDTVQ------------------VSSDN-----------------------------LTP
QIKDEED------------------------PQEMP-------------------RA-PS
GPTP----VVRD------------------------------------------------
----ESLERNDPK---EPQEVFITPSKK--------------------------------
----------------------------------------KGNK-RKR-----------S
IWSTPKKRHQK------K---------------------KLPRGKMRGQKE----EKLQV
VDQMAQRKDNSTC---NLKVVTRAQKTRTKCAQTSRSKEITDGTSEMNKR-KKSQATPST
P--PTVTQ----------------------------------------------------
----------------------------GA------------------------------
----------------------------------TSPGHGIQE------KLPVAGQVTQR
KT--------NNSTYN--------SKIMTRAQKAR-LNGKR-------------------
--------------------KKGICSSLKI--RLQK---NIGWREKPK-EDA-MDFQCPN
LPVTCGKEKGMLHVERMK--LG-PSKKCIQNEEGVRLTAKEFEIKGKGRNTEDWKQSV--
------RCRRKSLRQM--------------------------------------------
------------------------------------------------------------
----------LKRGQRVCCGTCPQ-----------------------------VFH----
-------DH----------IPPA--EAK--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MLHFQ
VHHKLAGIPEQLSDGQQMNIMEGDS-S-HDPNDT-VRTE---EMENKCA-----------
-------------------QEFEQTEF---CEH--SLLRMNNFS---------VPEE---
--RLNL------------------------------------------------------
-------------------LSYVGQ-VSYEHGTLQWTNGG--------------HFEEIP
K------LLPGD---GGASCELVALQ-------------------RDEGGESE-EMPRLL
PYDEE------------V---TYDSRAL---QMTN---ER----KPE-------EMPSL-
P-----------------------GEEGEE------------------HGHAI-------
--------------WDI-SDEEE---PQEVL-------------------SSP-------
-ST-CGPGS------------------C--------------------------------
-------DSESPQM--------------TS-EE---APEK--------------------
-------------------V----------------------------------------
-----------------------------PSQVLYDGEDSSSDCLEMYYE-EDPQEDWSS
PPES-------------ESSYGELEAVQINSEEELEELTSSLLPYDGQGA--------EP
PARG-------NEKCTC-VMCFSKYVPEGPEAS---------------IADS--------
---EA--CAMI-DTVDLRNNSTSGKLKRKR---RKKKGHCWTRHKRKFQRNLPQ------
---------KESSNTPGQLVSS-GKKGKMHLREPAKIKGKKRGRP--P------------
----VYS-----------------THGDRASRKRVR----SKGSRSHT-DCP-VDFRSQI
LPVTCGEVKGMLYKKKLK-QGGS-LVRSIQSEDGKWFTPREFEIRGGYARSKNWKLSV--
------RCGRRPLRWLMEK---GF LHN--PLRKYFRK----------R-KIIPK--SHNN
TLVNPY------------------------------------------------------
PGNSDV CEMCRDGGKLFCCDTCSRSFHEDCHIPPVETERNP----WSCTFCR MEF-----
-------LERQQCHGES-EVLER--QMQPEEQLK CEFLLLKVYCHSESS----FFSK---
-IPYYYYIKEVSQNLKEPMWLDKIKKKLNKQG-----------------YP---RVEEFV
QDMRLIFRN-----HRASYKY-NDFGLMGLRLEAEF-------EKKFKEV----------
------FSIEEANERSSLV-----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------PTIPR-EKN-VNFNLPK
LPVTCGEAKGTLDKKQFK--QGA-QMRSIRTEDGKWLTPRDFEIRGNHAAAKNWKLSL--
------RCHGWTLKELIEA---GH LPK--PPITRKK------------------------
------------------------------------------------------------
QKNSNK CEVCRQEKQLVFCSTCSRSYHQNCHIPPVDAQRSQ----WSCTLCR TKAWE---
----K-HPESQPCHLES-EVLKR--PMLPEEQLKCELILLKVYCYSQSA----FFAQ---
-EPYY--TQDP----QEHMWLNKVKERLNKKK-----------------YH---RVQGFV
RDMRLIFLN-----NKAFYRN-HKFIQLPLKIEAIF-------EKYFKNI----------
------FSIQETSESVCQFKHIIMT-----------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------LSRATIE-----DQNIEEKLVYETLFKHFKRYKVEISSAIKKPFPFFE
GLRDRELITNKMYEDCQ----ESCR-N-LIPVQK-VVYNVLNELEKTFNLPLLEA-----
--LFSEVNVQEYPDLNGIYRNFEHVVQ---EKI---HYGESYEE---------EVDE---
--NPNIQRSLE-QGTDENIY----R-S----LTWPC---PPSSSHQ--------------
--------------GTTSPENGPSK-NLCETEQINANRKDTTSDKNDALESQEANKECAQ
E------SELA------ESCEQASIQ-------------------VYNGDIRE-DTPSPL
PCDGF------------DPG-AELPNHG---IQMNSCSVY-----------------LV-
DIKKEKP-FFNST--------------VEQQAQARTN------------------YNQ--
--ASDIIVISSD-SEES-NDGEE---LPEASTST---------------LESRP----VT
NNL-DSLESSERG---ESQEVTCSRLQITLNPVDFRKSPIS-----QEGAW-KVVKRF-D
YSSE-SSEEEEP--MRASS---SALRSNPD-EE---DSAD---I-GNK-----------S
FWGINNR-----------------------------------------------------
-----------------------------------KRRISSGNFSELHRA-EESQESSNS
VLRSG------------------------------------------SG--------AES
QGL--GN-----EECSC-VMCLSKGISRGQGTR---------------TENS--------
---QA--SDMM-DTMDIGNNPTSGKHNEKIR--KKRRHIHKK---NNLQKGKI-------
--------------------------------QVR-----RRGRHRIQ------------
----SLIS-RALW-------SRGRKTTNTGPLRRGRK----RGPRIPR-DTH-MDFHRPE
LPVTCGEAKGILYKEKMK--QGT-SEKCIKGENGSWFTLREFEVEGNHSRSKNWKMSV--
------RCGGFPLKDLIEN---KYLPD--PPRRRKRR-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------MAD--
-------GGGDLSTRMF-----TEEQDVDEGLLCDAVFKHFKRHKVEISNAIKKTFPFLE
GLRDRELITNKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKMFSLPVLEA-----
--LFSEVNLQEYPDLIHIYESFKNVIK----DK--LPLRESDGE---------EREE---
--RPGIQLSLE-QGAGENSF-----QS----LTWPR---WGSPSHD--------------
--------------GSTPSENGLSE-HPCETEEINADRKDTTSDKNGLLGNQQTNEQCAQ
K------AEPT------ESCEPVAVQ-------------------VSNGDAGR-ETPCPL
PCDEE------------G---AEPHNHG---IQINSCSVR-----------------LV-
DIKKEKP-CCTS--------------NAERQAQ--------------------------A
S---DIIVISSEDSEGS-TDVDE---PLEVFISP---------------VRSKP----VI
NND-NSLESNKEK---EGQEATCSRPQTVPEPMDSRKSSIF-----REGFR-KRVIGQDH
NFSD-SSEEEAPPEVL--S---GVLRSKHG-ET---DPVTSRST---------------S
TWGIPNRKR---------------------------------------------------
-------------------------------------RFSSSDFSELSNG-EELQESCSS
SLRR------------------------------------------GSGS--------EL
QGPE-------NEKCPC-VMCFPKGVPRSQEAR---------------TESS--------
---QA--SDMM-DTMDVENNSTLEKHSGKRR---KKRKHILKVNG-LQRG----------
---------------------------------------RKKHRHRKH------------
----LTRNNKVPKE---RRQPRGRKTN-NRPLKRRRK---RG-PRIPR-DKN-INFKLPA
LPVTCGDVKGTLYKERFK--QGI-SKKCIQSKDGRWFTPREFEIEGGREASKNWKLSI--
------RCGGYTLKFLMEK---ELLPE--PPSTRK--------------KRILE--SHNN
TLVDPC------------------------------------------------------
PENSNICGVCNKWGQLFCCDTCPRSFHEHCHIPPVEVNKNP----WSCIFCRIKTIQ---
---ERC-PESQLWHQES-EVLMR--QMLPKEQLKCEFLLLKVYCDPKSP----FFAS---
-EPYYN--KEGSQGPQKPMWLNKVKRNLNEQA-----------------YS---RVEGFV
QDMRLIFRN-----HKEFYRE-DKFITLGIQVEDNF-------EKNFRNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTVTRAMEEALFQHFMYQKLRIAYAIHKPFPFFE
GLLDNSFITQRMYMESL----EACR-N-LVPVSK-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGEQQSRASCEQQSRDT---------P------
-----ILLEAP-TGLAGGS---------SLHTLLPLPPPQPPQPSCSSCAPRVSEPGTSS
-------QQSDEILSESPSPSDPT------------------------------------
----------------------LPLPGLIQEGRNTPVTNDKLTPKMNEEEDSE-EMPSLL
ASTVQ------------------VASDN-----------------------------LIP
QIKDTED------------------------LQEMP-------------------HS-PS
GPMP----EIRD------------------------------------------------
----DSLEPNDPE---EPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-SKR-----------C
IWSTPKKRHKKKSLSRG-----------------------------TASPRHGIEKKLKV
VDQVPQKKDDSIW---KSTVMTRAQKARTQCAQKSRSEEISDGTSKMNEG-NRYQETPST
PSRAK-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------ASPGRDVQE------KLQVVDKVTQR
K---------DDSTWN--------SKVMTRVQKAR-IKCTQKSRSEE-------------
----------------KKRE-KDICSSSKR--RFQK---NIRQRKKPK-SDA-VDFHRSE
LPVTCGEAKGILYKAKMK--HG-SSTKCIQNEKGAWLTPKEFEIEGKGRCTKNWKRSV--
------RCGGKPLLQLLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCKGGKLLWCGTCPRAFHEDCHIPPVEAKRTP----WSCTFCRMKRS----
-------SGSQQGHRGS-KILER--RMQPQEQLKCEFLLLKACCHPQSS----FFTA---
-IPLNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLIFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKDV----------
------FDFHKANDSSFRTPP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGSDLSTRRLNGGVSRVENEMNYLP--
-------AHSQSLQRI-----FTEDQDVDEGLLYDTIFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEVNMQEYPDLIHICKSFNNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DQK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQEEVPESPEAK---------------MENG--------
---QA--RGKM-DTVGIGNNSTLEKPKRKR---KKKKGHSWTRIKSRTQKKIQQ------
---------HDNSKPGG-QLVPNEEKAKVNLQGLSKLSGSKRSKPGT-------------
----HF------------------TQSDRAPQKRVR----SRASRKHK-DET-VDFQAPL
LPVTCGGVKGILHKEKLK--QGS-FLKCIQTEDGNWFTPGEFETKGGYARSKNWKLSV--
------RCGGWPLQRLMKE---GSLPN--PPKIHYR-----------NQKRILK--SHNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFI
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------A-------------------------G--
-------EGSELSTRMS-----TENQNTEDRLVFETIFRHFKRHKVEISTAIKKTFPFFE
GLRDRELITNKMYEDCQ----DSCR-N-LVPVPK-VVYNVLSELEKTFNQSLLEA-----
--LFSDVNMQEYPDLNHVRKSFENGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MF-----GVIQ--KEECFNEVFLNYFKENKIEIAHAITKLFPFLE
SLRDRSFITDKLYADSY----EACR-N-SVPVAK-VVYNVLSHLEK-WDSSFLWA-----
--LFNRVNLKEYPALREIHKSLETGRD----KL--F-QP---------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
---------------M----------ISMSKALEEALLQHFTYTKLDIAYAINKPFPFFE
ALRDNSFITEKMYTESR----QACQ-N-LVPLSK-VVHNVLTSLERTFDVSLLLT-----
--LFSQVNLREYPSLVAIFRSFKN---VVT-----AYEGNKRTA---------Q------
-----SLLQVP-TDLAEGH---------SFRTLLPS--TQPSLPSRLSSAPRVFEPGAAS
-------QQITEILDEQPSPSHTA------------------------------------
----------------------APPPGFIQKGKTTLESSRDP--PRNDKDDSL-EISPNP
SGSMP------------------AVK----------------------------------
------------------------------------------------------------
-----------D------------------------------------------------
----EPPAPNDLQ---MPQEAPSTPANK--------------------------------
----------------------------------------KAKR-KKR-----------C
IWSTPKRRHQKKRPPQ---------------------------GEGVTSPGHGVQGKLKV
VGQRTPWKSDSTR---T-------QEARTKCAQTSRSQEISNGASETNGR-RRPQRMLSL
SPKA--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T--R----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
D------GGRDLSTRML-----TDAPHAEDL--MVTLFQYFKAHKVEISYAIKKTFPFLE
GLRDRELITNKMYKAYQ----DSCRES-LVPVHR-VMYNVLNDLEKIFDMAVLEA-----
--LFSEVNREVYPALMNIYKDFQNVIH----DK--LYLQESDGE---------EREE---
--RPNTQLRLE-EGTRRNSV----SRS----LTWSR---SEPSPSG--------------
--------------GTNLPENELPH-QAHKREQINGLRTETTKERNDTPGSHQTDEQPVQ
E------SAPG------KSLEEVAAP-------------------ANNGDASV-EPLRPL
ACGEE------------R---TELHSQG---IQVSSCSVL-----------------LV-
DIKKEKP-FYS---------------EDEQRAQRR----A--------K------PAR-P
P---DIIVISSDDSEDL-SDEDE---PPKASTSA---------------LRSEP----VI
SDH-DPLESSEEE---ETQEASCSR-QSTPKPMDFR---TF-----RKSPL-KRGREHVH
NSSE-SSEEETLPQIDFCS---SEWRSGPS-TT---EPVHTGKP---------------S
TWGTYNWKR---------------------------------------------------
-------------------------------------WLNSGGSSELNHR-EEHPE----
TLRS------------------------------------------GSGA--------EL
QGPG-------N-KCSC-VMCSSECVPGGQDTR---------------MESG--------
---RA--SYTM-DAVDVGNNSTLGKDIGKRR---KKERHTCKINP-LQ------------
-------------------------------------KGRKRGGSRIL------------
----STLSNGAPRK---RGWPKGRKRANTKLLRRVR----KRGPRIPK-ETN-VNFNIPE
LPVTCGNAKGTLYKEMFK--QGV-SKKSIKGEDGSWLSPREFEVRGNHAASKNWKLSV--
------RCHGWTLKELMTR---GYLPE--PPSRRKKKAIIRMGASASRTQRTLD--SYLN
APVDPY------------------------------------------------------
PENSNECEVCAQGGQMYCCDTCPKSYHENCHIPPVETESNP----WSCIFCKTKAIR---
----KKYRESQPCHQES-EVLMK--ALCDEEQLKCELLLLKVYCCAESA----FFVT---
-EPNYT--KGASVGQPARVCLDQIKARLNEKK-----------------YS---RVKEFV
QDIRVIFQS-----HKPFYRE-KKFISLGT-LEDKF-------EKNFKTI----------
------FGVQKTTPDNHLLPHSGSFSS---------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
SLLDNSIITNRMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGA-----SYEWQSRDT---------P------
-----ILLEAP-AGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLNQEGRSTSVTNDKLTSKMNEEEDSE-EMPSLL
TSTVQ------------------VASDN-----------------------------LIP
QLKDK-D------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDAE---EPQEVSSTPPNK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKKRPKKKSLPRG-----------------------------TASPRHGIQKKLKR
VDQVPQKKDDSTW---NSMVVTRAQKARTECARTSRSEEIIDGTSEMNEG-KRSQKTPST
PRRVT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------TSPGHGIQE------KLRVVDKVTQR
K---------DDSTWN--------SKVMTRVQKAR-TECARKSGSKE-------------
----------------KKKQ-KDICSSSKR--RFQK---NIHRRRKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SLMKCIQNEDGTWLTPNEFEIEGKGRNAKNWKRNI--
------RCGGTTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCKGGQLLCCGTCPRVFHEDCHIPPVEAKRTL----WSCTFCRMKRS----
-------SGSPQCHHVS-KILER--QMQPQDQLKCEFLLLKAYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLIFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKHM----------
------LGFHEANGGGFWTLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------L-F
S------HGFSVPSRMS-----TEQEN-TEGIPFETLFPHFKRYKVAISQAIKKPFPFLA
FLRDNELISDKMYQDFQ----DSCT-N-LVPVEQ-VVYRALEELEKRLDLVVLGV-----
--LFSEENVKAYPDLEHILQSFQSGN----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFSIGQNKKISHEALLNHFKENKVEIANAITKPFPFLE
SLRDRSFITEDIYNKSQ----EAHR-N-LIPVEK-VAYDVLCCLEKTFDRSLLQV-----
--LFSRVHLKEYPALIHVLGIFKNVIE---DKY---FPQEDDSE---------ETQK---
--LPSTEPSCE-QVISS-------------------------------------------
-------------------------------------------------------ESSEE
EE-------P-----------PEALS-------------------SAPGQGP--------
------------------------------------------------------------
------------------------------------------------------------
----------DEKSEGC-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FNITRDLKETLRQHFIFQKLEISYAICKPFPFLE
GLRDKSFISDKMYMESM----EACR-N-MVPVSK-VVYNILTKMEEPFNLSFLEM-----
--LFSQINLREYPNLVAIHRSFRN---VVA-----SCGGWRGAT---------V------
-----TVFEVP-TNSRGRS---------PHQNLLPLPAPQRPPLRCPTPVPRVNQPSAIP
-------QHSNKVLDKPPSSAGPA------------------------------------
----------------------KALPRVIQEGRTTP---ANLTSRINDKEDSQ-QVPSTP
PATVQ------------------VSSDH-----------------------------LTP
QAKDKED------------------------AQEMP-------------------QA-PS
APEP----VIRN------------------------------------------------
----DSPEPNEPA---EPQEAASTPLIK--------------------------------
----------------------------------------KGKK-RRR-----------S
MWSVPKKRQQKKRLSKG-----------------------------TASPGQRIQEKLQM
VDQVTQRKDDSTR---NPKVVIRTQKARTKCAQTSGPEEVSDDTSDMNET-KSPQDPPST
PPRITQGTT---------------------------------------------------
------------------------------------------------------------
-----------------------------------S------P------VPQMVDQATQK
K---------NNSTGN--------SRVMTRAQKAK-TECAQTSGPEE-------------
----------------KK-RKKDVCSSSTI--SCQK---NIPQKEKPK-DDT-VDFQSPT
LPVTCGGETGILHKEKME--KG-SSEKCIQNEEGVWFTPREFEIKGRGTKSKDWKRNV--
------RCKGQTLQRLMEW-----------------------------------------
-----------------------------------------------------------E
--NS N ECEVCCREGQLLCCDACPRAFHEDCHIPPMEAKRSP----WSCTFCRMKES----
-------SGSQQYLRGS-EVLTR--QMGPEEQL---------------------------
-----I--RDYAEPFKEAMWLDLVKERLTEKV-----------------YTVEW----FV
RDIRLIFHN-----HKTFYKA-SALGQIGLDLEAKF-------EKDLKEV----------
------FIF---------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMVTD-----------IQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNAN---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DAEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGP-------------------CLPDEGE-EG
S-G-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGSDDCSQMCDG-EEPQEASSS
LARC-------------GSVSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRMQKNVQQ------
---------HENSKGNGQVVSNE-KKANVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKEKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-----------------------------------------------------MRLGVRD
Q-----------------P---------------GQYGETLMVT-----------EIQ--
---------------------NVEGQNLQEQVFPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVAR-VMYRALSELEKTFGWSHLEA-----
--LFSRVNLMAYPDLNEIYRSFQNACY----EH--PPRQVNNVS---------GLED---
--RPRLLLCDK--QENSNAC----HKTCAVAVPQEA---LSS------------------
---------------SPKCGPGFSS-ESHEQLALPRADGG--------------GAENAP
S------LLPGG---GM-CCEPAVQ---------------------VDEGESE-EMPQLL
PYDAE-------------------------------------AP---GRKERGKNSPR--
-----------------------------ERN-------------------QYKEKYQER
EF----SKTFDLNTPKI-TNKGE---PEKRL-------------------SLLPGEGEEG
S-D-DCLEMRDGK---EPQEASSSLVCPQVTLCG---------------------LSISC
FSAE-TFDINAPQI--------------TN-EG---EPEK--------------------
-------------------R----------------------------------------
-----------------------------LGLLPIEGEEGSDDCSEMCDR-EEPQEASSS
LARRGS-------------VSSELKDHQMNEEEESEELVSSLLHKDVPGA--------QQ
LACE-------NEKGSC-VMCFSEEVAGGPEAR---------------TESD--------
---QD--TVDT-G-----------S-NSAL---GS-------------TKPKRK------
---------RSNGKADG-QLMSSEKKANVNLQGPSKIRRIKRGGPRVC------------
------F-----------------TQSNRAPQKRVR----TRASRKRK-DKT-VDFKAPL
LPVTCGEVKGILHKKNLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMES---GFLHN--PPRN--R-----------KKKRILK--SHKN
TSVDPC------------------------------------------------------
VSTNSELLL----------PECPTPFSR-----HMFCVMTP----WSCIFCRMKES----
-------AGSQQCCQES-EVLER--QMCPEEQSKCEFLLLKLYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHD-----------------YS---RVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNLKEV----------
------FAIQETNGIN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MSTE-----QDTQN--IAFEHIFLHFKRHKVAISTAIKKPFPFLE
FLRDNELITNKMYDDFQ----DSCA-N-LVPLQR-VVYRALEELEKRLDMVVLGL-----
--LFSDENMKAYPDLELIFQSFQNVLQ---NKL---CSQG-------------SDRG---
--DPNSQLSLD-QGPGDSCS----QGS----LTWSP---SDPSSSD--------------
--------------GWRMNGTKD----------T------TLAQENQIEN-----HQYSS
L------QIHN------ESCELEV----------------------HQS-----------
----N--------------R-PQLRSQG---TQVYPCSMK-----------------LG-
DIKQENS-SFVLD--------------SEET-KPRTS------------------HNQ--
--ASEV------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------IEKKE-------------------------------DSHGKYL--------
----IRN-IKIPNKVKCVS-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------AGPRIRR-QFN-VNFVCPE
LPVTCGTAKGTLYKEKFE--QGI-HAKSIRSETGRWFTPMKFEIKGNRGDSKNWRQSI--
------RCYGWPLKELIED---GYLPD--PPRKRGKV-------------TIP-------
------------------------------------------------------------
------------------------------------------------------------
----------RPP---------P--PIAFHLLQKCELLLLTIYCHSKSR----FFIP---
-KPKQR--KEDFPDLQEHMWLNKIKYRLNKKA-----------------YH---SVQHFV
KDMRLIFRN-----HSIFY-N-VRFSYLGVTVGELF-------EKTFKRI----------
------FSIKDASK----------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
-------------PSNTGNDSTLRKRKRXX---XXXXXXXXXXXXXXXXXXXXX------
-----------XXXXXXXXXXX-XXXXXXXXXXXXXXXXIKRGQPR-I------------
----HLL-----------------TQGTKVPRKRGR----PKGSRK RT-YET-VDFHAPS
LPVTCGQVKGTLYKKKLE--QGI-SEKCIESEDGRWFTPREFEIKGGYGRSKNWKLTL--
------LCGGRHLQWLLKK---GFL PY--PPRIYQKR----------KKKRLEH---NIR
AVVDPH------------------------------------------------------
PDNSN DCAVCQTGGELFCCDTCSRSFHKECHIPPVEVERL--------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

MWCFSWTLHVTYPNSLYRDCAERVAATLRLTCTLGSPSGWALLGHPAHSWLQPLSTLHQV
GRDKWIPSPQQPPGWCPAPPPPPSPG---APMGSTPTPTPFCAARRE----GSTRWPQ--
LPAFGRGTL---------SLFFPLQPAPEGA--RGLSVSSVAVSCELSSQFSGRIPCPAP
GTRKGQEPVANPALRM----------FTLSSALEKALLQHFILYKLEIAYAINKPFPFFE
SLRDKSFITEGTYRESL----EACR-N-LVPTSR-VVYNILTKLENTFNLSLLMT-----
--LFSQINLCEYPNLRMILRSFIN---VST-----SYREPSGAT---------P------
-----TPLRAP-ADPAEGS---------SLQTLLQRPPPQPPPPRHLCL--IVGETTAPL
-------QQIHESLDKPPSPSGPA------------------------------------
----------------------VPLPGLVLGEGSTPVANGNLTSNTKE------------
------------------------------------------------------------
-----ED------------------------ARERP-------------------RL-PT
GTVQ----VIQD------------------------------------------------
----ASSEPSDPK---EPQETPSTSPKK--------------------------------
----------------------------------------KGQK-RKR-----------C
IWSSPRKRYKRKSLPRG-----------------------------AASPGRGGQEKVQV
VD---QRKDDPAW---NSRVVKRTQRTRTKCAQTSSS-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------KEKAK-EDT-VDFLAPT
LPVICGEAKGILYKEKLE--RGGASEKSIQNEKGAWVSPKEFTIEGKMERSKCWRRSV--
------RCGGKSLRELIEN-----------------------------------------
------------------------------------------------------------
--------------GILLCPPGRNLKSKVPSS----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------LLQ
F------CSDLSYFLVLTE-----DEDVDERLLCDTLFKHFKRYKVEISNAIKKTFPFLE
GLHDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLSVLDA-----
--LFSDVNLQEYPDLIHIYKSFENVIQ---DKL---RLQESEGE---------EREE---
--RPDMQLSLE-QGTGENPF----R-S----LTWTR---SGSPSYD--------------
--------------GTTPPENGLSE-HPCETEQIYAKRKDTTSDKNDALGSQQTNKQYAQ
K------AEPA------ESCKQAAVQ-------------------VNNGDAGR-ETPSPL
PCDEE--------------R-SQLLNHG---VQINSCSVR-----------------LV-
DIKKEKP-FFNSK--------------VERQAKARTD------------------HNQ--
--VSDIIVISSEDSEGS-SDVDE---PVEVCISA---------------LKSEP----VV
NND-NPLEASEEE---EDQQATCSRPQIVSGHLLLSA----------------VIGQD-H
DSSE-SSEEEEI--PKVLI---RALHGKKG-KN---SPLD---F-RAL------------
------I-----------------------------------------------------
-----------------------------------SERFSSTDFSELSNG-EEPQETCSS
PLRSG------------------------------------------SG--------KED
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
D------GGSDLSTGVF-----TEDQDVDEGLLYDTLFKHFKRYKVEISNAIKKTFPFLE
GLHDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLDA-----
--LFSDVNLQEYPDLIHIYKSFENVIQ----DK--LRLHESEGE---------EREE---
--RPGIQLSLE-QGTGENSF-----RS----LTWTR---SGSPSHD--------------
--------------GTTPPENGLSE-HPCETEQIHAKRKDTTSDKNDAVGSQQTNKQYAQ
K------AEPA------ESCEQATVQ-------------------VNNGDAGR-ETPSRL
PCDEE------------R---SELHNHG---VQINSCSVR-----------------LV-
DIKKEKP-FFNS--------------KVERQAKAR----T--------N------HNQ-V
S---DIIVISSEDSEGS-SDVDE---PVEVCSSA---------------PRRDP----VV
NNE-NPLELREEE---EDQEATCSRPRIVSEHRDCRKSPIF-----RESFR-KRVIGQDH
DSSE-SSEEEATPEVL--S---WAL---HG-KK---DPMTSGST---------------S
TWRIHNRKR---------------------------------------------------
-------------------------------------RLSNTHFSELSDG-EEPQETCSS
PLRS------------------------------------------E-------------
-----------------------SGVPRSQEAR---------------PESS--------
---QA--SGMM-DTMDVENNSTLEKHSGKRR---KKRRHMFKANS-LQKG----------
---------------------------------------RKRGRPRKH------------
----LTWENKVLQT---RRQPKGRKTN-TTPLKRRRR---RA-PRIPR-DKN-IDFEQPE
LPVTCGELKGTLHKERFK--QGT-SKKCIQIENKKWLTPREFEKKGGRGASKNWKLSI--
------RCGGYTLKSLMEK---RH LPV--PPTTRKKKQRLPEPPTTRKKQSILK--PHNN
TLVDPYR----------------------------AQSQLECVAVCDEQRIPDASPDTSQ
PENSN ICKVCNKGGTLFCCDTCPRSFHERCHIPPVEAKKDP----WSCIFCR IKAIQ---
---ERC-PESQPCHQES-EVLMR--EMLPKEQLKCEFLLLKVYCDSKSP----FFAS---
-KPYYN--REGSRGP QKPMWLNKVKRRLNEQV-----------------YS---RVEEFV
QDMRLIFHN-----HKEFYSE-DKFITLGIQVQNTF-------EKNFKNI----------
------FAIQETSKNIIMFI----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFGVIQKEERFNEVFLNYFKENKIEIAHAITKLFPFLE
SLRDHSFITDKIYADSY----EACR-N-SVPIVE-VVYNVLSHLERLSDSSFLWA-----
--LFNRVNLKEYPALREIHKSLGTELQ---DGY---SPQKCKQE---------EQKK---
--LATVHPSYE-QGTNLCTH----------------------------------------
-------------------------------------------------------EKWAQ
PC-------FV------K---QDNLQ-------------------EPEIQ----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--VDEIILISSESSECS-DEDEE-----D----------------------Q--------
-------------------------A----------L-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GTGLRRQMNKE-AE-------
-DSSP------------------------------------------PGFQN-----IEL
P-AGS--------HTSCVWTNHS-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTKAIEDVLLQHFIQTKLDIAYAINKPFPFFE
ALRDHCFITEKIYKDSL----DACR-N-LVPVSR-VVHNVLTSLERTFHPSLLLT-----
--LFSQVNLREYPSLGEVFRSFKN---GNV-----VSPKSFPCA---------V------
-----LLY----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFGVIQKEERFNEVFLNYFKENKIEIAHAITKLFPFLE
SLRDHSFITDKIYADSY----EACR-N-SVPITK-VVYNVLSHLERLSDSSFLWA-----
--LFNSVNLKEYPALREIHKSLGTELQ---DGS---SPQKRKQE---------E-QK---
--LATVHPSYE-QGTNLCTH----------------------------------------
-------------------------------------------------------EKWSQ
PC-------FV------K---QDNLQ-------------------EPEIQ----------
------------------------------------------------------------
-------------------------------------------------------QNQ--
--MDEIIVISSESSECS-DEDEE-----D----------------------Q--------
-------------------------A----------L-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------GTGTQKADGQR-D--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------Q--
---------------------SPEDQNPEEQVFYEFIFRLFKENKVEIASAITKPFPFLM
GLRDRGFISERMYNRFQ----EACI-N-MVPMER-VAYNVLSQLEKKFDMTVLNA-----
--LFSTVNLKAYPDLLEIFRSFQNV-C---CEH--SPVQMNNAR---------GLED---
--RPSLLPHDG-QEEDRKAC----CVTCDGEEPQEA---LSS------------------
---------------PRRHEPGFSS-VSCEHEALQRTRGG--------------DSEEIP
K------LLPVD---RGVPLELVDLQ-------------------MDERGEIE-EMPKLL
PYDGD------------V---LESCRIR---QEKDITHGL----GKQEGKKGGGSRH---
--------------------------GKKKNWD--------------------KEKCQEI
P-SARIRVTCDPKASEM-TNEGE---VQKVL-------------------SLQPAEGEED
S-I-ASWEPCDGE---EIEENLSSPPRC--------------------------------
-------EPGKKHGSE--I---FLLKTTTNESQ---DQER--------------------
-------------------E----------------------------------------
-----------------------------VNEMGTEADQGLIGSQEPCDG-EELEEDLSS
PPRC-------------EPVSGELEAPQMGREGESEELTSSPLPCDGQGV--------EL
PTGG-------NDKYAC-VMCFSNDMPGSLEAR---------------TESS--------
---EA--CDTI-DNVDLGNNSTLGKPKRKR---KKKKGHSWFRIKRKQQRNIHQE-----
---------AYPNKAVGQLVLS-RKKVGMNLQDPVKIRKRTKGLHKSS------------
----INF-----------------TGTDRMEQKYVY----SCEYVKHR-KCT-VEAKSPS
LSKSYGVARWRIILSAQDDRTSC-SCLCILL------------SLIKNRSSLNWQISGPV
TTAVVPLCLSKP-LWLMEL---TGFWK--QSPTLGLR----------AKRRISQ--SHDN
TLVDPY------------------------------------------------------
LGNSDVCEICRYGGKLFCCDTCSRSFHEDCHLPPVDIERSP----WSCIFCRM E-S----
-------SGSQQCLRES-EVLAR--QM GPEEQLKCEFLLLKVYCDSEST----FFSK---
-IPYYYYIKETSQHLKEPMWLDKIKKRLIKLG-----------------YP---QVEGFV
KDMRLIFQN-----HRASYKY-NDFGLMGLRLEAEF-------EKNFKEV----------
------FAIQETNESS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MLTG-----------SQ--
---------------------NPEDQMSEEQVFYEFIFRLFKENKVEIASAIKKPFPLLM
GLRDRGFIPEQMFQHFQ----EACR-N-LVPVER-VIYDVLSELEKTFDKTVLDA-----
--LFSNLNLKAYPDLLEICRSFQNV-I---RDN--FHYEAM-------------------
--------------------------DEE-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------E---TKEVL-----------------------------
-HF---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------QMH------------------------------
------------------HKAMGEYVPEGPEAS---------------TASS--------
---QA--CDTM-DTADLGNNSSSGKLKRKR---RRKKGHAWTRIKRKYQRKLHQ------
---------KDSSNTAGQLVSR-GKKVKMRLQELAKIKRKGRLFT--P------------
----IYL-----------------THSDRTPWKRVW----RRGSRRRRKDDR-VNFHSQI
LPVTCGEVKGMLYKKKLK--QGV-LVRCIQSEDGNWFTPREFEVKGGHARSKNWRMSV--
------RCGGMPLRWLIEK---EL LHN--PPRKYFRK----------R-KTIPK--AHNN
TLVDPY------------------------------------------------------
LGNSDE CETCRDGGELFCCDTCSRSFHEDCHIPPVETERSP----WSCTFC RIE-S----
-------LGRQQCHRES-EVLER--QMQPEEQLK CEFILLRVYCHSESS----FFSK---
-IPYYYYIKEVSQNIKEPMWLDKIKKKLNKQG-----------------YH---QVEGFV
RDMRLIFHN-----HRMSYKY-NDFGLMGLRLEAEF-------ERKFKEV----------
------FAIEETNESS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTLTKALEKALLQHFIYMKVNIAYAINKPFPFFE
ALRDKSFITERMYKESL----EACQ-N-LVPLSK-VVHNILTSLEQTFHPSVLLT-----
--LFSKVNLREYPSLVAIFRSFRN---GNV-----VSPILVTCA---------V------
-----VLQ----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLRIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----ILLEAP-TGLAEGS---------SLHTPLVLPPPQPPQPSSSPGAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLVQEGRSTPVTNDELTSKMNEEDDSE-EMPSLL
ASTVP------------------VASDS-----------------------------LIS
QIKDKED------------------------PQEMS-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSYK--------------------------------
----------------------------------------KGKE-SIS-----------P
VEVRRVNSELLSVFLCLVKSTTM-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
G------GDNELSSRTIP-----EDQNEEESDDYQLMFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LAPVER-VVYDILSNVQKKFSRDLLKV-----
--IFSKTHLKVYPDLKETLKHFFLNA----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------S-------------------KTNDEQAE-EMLSLP
QCNGG--------------V-LAQ----------EHSNPH-----------------VKR
SVPVSCV-PQH----MCQKTWKQGWEAAKEKV--W-------------------------
----------APGGTFL-QENPR-----SRESWQ---------------VWSLH------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------C-------------------
------------------------------------------------------------
----------------RPW-----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------SFGEAWNSEEQAHYELSFRYFKENKVEIASAITKPFPFLM
SLRDRGFISEQKYKLFQ----ERCE-N-LVPVNR-VMYDVLSDLEKMFGQPLLRV-----
--MFSPTNLKEYPDLKEIFRSFPFGNYKGS------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--S-PCSPAINGQ---EPQDALRASPRP--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------G
VASG-------NEKCSC-VMCAPRCMQEDPEAR---------------TGSR--------
----------------------------QK---GKKKRHNWIRVKRKKQK----------
------------------------------------------------------------
----------------------------------------------LK-VKN-ADFSAEL
LPVTCGKLKGILYKEKLK--QGI-SVKCIQSEDGEWFTPHEFEIRGGYARSKNWKLSV--
------RCHKIPLKRLIEVFQGGRGAP--LLG----------------------------
------------------------------------------------------------
--------------ALF-----TRCIVVDC-LPYVQPLRTS----WSCIFCRVMQF----
-------LGSPQSHSES-EILQR--QMQPEEQLKCEFILLKVYCCPESS----FFAK---
-MPYYYYFKETLQGPQNHIWLDKIKKKLNKQN-----------------YS---QVKEFV
QDMRLIFQN-----HRASFKY-PKFGQMGLKLEAEF-------EKIFKEV----------
------FAIQETNEDS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------I-----TEDQNRKQQVSCEHIFKHFRINKVDIASAITKPYPFLM
ILRDHAIISEQMYKHFQ----DTCA-N-LVPVTR-VMYDVLHELEKTFCPSLLKV-----
--LFSRANLQAYPGLREILRSFPN------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGGGGDLSTRM------------------
---------------------FMEDQDIDEGLLYDTLFKHFKRHKLEISNAIKKTFPFLE
GLRDREFITDKMLEDSQ----DSCR-N-LVPVQK-VVYNVLSELEKTFNLSVLEA-----
--LFSEVNMQEYPDLIHVYKSFKNAIQ----GK--LCFQ---------------------
------------------------------------------------------------
-----------------------------------ESDGK--------------EKEERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------QL-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------SLKQEEVPEGPEAK---------------MESD--------
---QA--CGQM-DTVDIGKNSTLEKPKRKR---RKKKGHSWTRIKRTTQKKVQQ------
---------NNNGKADG-QLVSGEKKGNVDLQGPFEIRKRKRGRPRTR------------
------F-----------------TQSDRDPQKRVQ----SRASRKHK-EKT-VDFKAPL
LLVTCGEMKGILYKEKLK--QGI-LVKCIQTEDGNWFTTREFEIKGGHTRSKNWKLSV--
------RCGGWPLRQLIEE---GS LPN--PPRIYYR-----------NKKRILK--SHNN
TSIDPC------------------------------------------------------
MRNLDE CELCRDGGELFCCDTCSRVFHEDCHIPPVETEKTP----WSCIFCR MKES----
-------SGSQQCCQES-EVLER--QMCPEEQSKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHS-----------------YS---RVEGFV
RDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNLKEV----------
------FAIRETNWNH--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTVTRALEEALFQHFICQKLEIAYAIHKPFPFFE
GLRDKFCITEKMYKESL----EACQ-N-LVPVSR-VVHNVLTQLERRFHLSFLMT-----
--LFSPINLREYPDLMTIYRSFKR----GN-----LKGQQKRKN---------RPPK---
--TSIKMTAAP-ADPAEGSSNVQPPRQYLLPQLPLLPPPPTHPPRAP----RVHQPEAYT
-------HQSSEILGERPSPSGPA------------------------------------
----------------------GALPEFIQEGRITPVLHDNLIPKTNDK-DSQ-EMPSVL
PDPV--------------------------------------------------------
------------------------------------------------------------
---Q----GIKE------------------------------------------------
----DSPEPNGLQ---DPQKVSSTPPNK--------------------------------
----------------------------------------KRKK-RKR-----------S
VLSTPEKRHQK------K---------------------IFRQVLPLCKEGVRVRETWKK
TEKRYLFKATSSC---HKQVVW-------SCLQRSKQR----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
RE--------QNS---------------NSQKKTR-LNGLT-------------------
--------------------ETGETP--RV--FPPA---TLLVSERPE-DET-VGFHSAK
LPVTCGEEKGVLYTEKMK--RG-PSEKCIRNEKGAWYTPKEFAISGNRAKSKNWKQNV--
------LCRGQTLGQL--------------------------------------------
------------------------------------------------------------
----------LEKGLLLCPSRISL-----------------------------KEQ----
-------EE----------GD---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
Q-----------------QGQM---------ASGDSNLNSRMVTD-----------IQ--
---------------------NTEDQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--PPLQMNNAN---------ELED---
--RPRLLPYGK--QENSNAD----HEMGDVAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPNADGG--------------DAEDAP
S------LLPGG---GV-SCELAIQ---------------------TDEGESD-EMPTLL
PYDTE------------V---LE-SNRM---TDAARTYST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QDKEKYQES
PA-ARDRETFDLKTPQI-TNEGE---PEKGP-------------------CLPDEGE-EG
S-D-DCSQMCDGE---EPQEASSSLARC---------------------------GSVSC
FSAE-NLDLKTPQI--------------TN-EG---EPEK--------------------
-------------------G----------------------------------------
-----------------------------LCLLPDEGEEGSDDCSQMCDG-EEPQEASSS
LARC-------------GSVSGELEDHPMNEEGESEELASSLLHDDVSGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPEGPEVK---------------MESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKK---RKKRGHCWTRVRRRTQKNVQQ------
---------HENSKGNGQVVSNE-KKANVNLKGLSKIRGRKRSKPRTH------------
------F-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQSEDGNWFTPREFEIKGGHARSKNWKLSV--
------RCGGWPLRWLIEN---GFLPN--PPRIYSR-----------KKKRILK--SHNN
TSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIRGTCQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
G------RGSDLSTRMSIE-----DQSAEERLIYEAVFTHFKRHKVEISSAIRKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQK-VVYNVLRELEKTFHWAVLEA-----
--LFSEVNLQEYPDLISVYKSFESVIH---DKL---PYQDDGGG---------ERGE---
--RSTFRLRLR-QGAGEPSF----QQS----LPWCP---SDASSSD--------------
--------------GTTLPGNGHSG-MPHDAEQTQARRKDTSRAPDDAPGSQQASEPSAQ
E------AEPA------ESTDTGAAK---------------------DDNART-ETPSPL
PCGEP------------SVS-SKPPSQG---IKVNSCSVL-----------------LV-
DIKKEKP-FFNSE--------------VEERAQARTN------------------CKQ--
--PSDVIVISSEDSEDP-SDGEE---PPKASTSA---------------LRGES----LI
PRD-NTVEQIKEQ---QNLAVSCLRNLLLPEPTDFRKSSPI-----RKSLT-KRVRRQ-D
QDSSGSSEDEPC--PVSWI---LGQKAELG-KE---APVT---I-GTT-----------S
TWWNHNQ-----------------------------------------------------
-----------------------------------KRRPGSGGSSTLSSG-EEPQEAASS
ALPSG------------------------------------------SG--------AEP
QGP--RN-----KECSC-VMCFPSGDPGGQEAR---------------TKSD--------
---QA--SGKM-VKLSISHLFTLIRNAGHRR--LNRRGRRKL---GGGVGGQ--------
--------------------------------RP------AQSGHRRE------------
----ALLA-SQVSR---RKWQERIKRFNSGPLKGNRK----RCPRNPI-GKH-ADFLLPE
LPVTCGFMKGILHKELL---KGA-SAKCIECD-LGWLSPREFEVAGNHIASKNWKKSL--
------QCHGFSLKSLIEE---GLLPE--PKGTRKKR-------------GVQ-------
------------------------------------------------------------
------------------------------------------------------------
----------RAR-------------------GRTVSQ-------GKPL----RFHP---
-RAQTP--GFGFQRKPHSVGPAL-------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------IQ--
---------------------NVEGQNLQEQVCPEPIFRFFREHKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--VFSRINLMAYPDLNEIYRSFQNVCH----EH--SPLQMNNVS---------ELED---
--RPRLLPYGK--QENSNTC----HEMGGVKVPQES---LSS------------------
---------------SPRCEPGLSS-ESCEQLALPKADGG--------------DVEDAP
S------LLPGV---GV-SCELAIQ---------------------IDEGESE-GMPKLL
PYDTE------------V---LE-SNKM---IDVAKTHST--APGKKEGDEEGRNSPG--
-----------------------------KRN-------------------QHKEKYQES
PV-ARSRETFDLKTPQV-TNEGE---PEKGL-------------------CLLPCDGEEG
S-D-DCSEMCDGE---EP------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------QEASSS
LARR-------------GSVSGELEDHPRNGEGESEELASSLLHDDVPGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGRPEAR---------------TESD--------
---QA--CGTM-DTVDIGNNSTLGKPKRKR---RKKRGHSWSRMRRRRQKNSQQ------
---------NDNSKADGQLVSSE-KKVNVDLKGLSKIRGRKRGKPRTC------------
------L-----------------TQSDRAPQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLK--QGI-LVKCIQTEDGNWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GF LPD--PPRIHYR-----------KKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDE CEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WSCIFCR MKES----
-------SGSQQCCQES-EVLER--QMCPEEHMKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREAC QGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFI
QDMRLIFQN-----HRASYKY-KDFGQMGLRLETEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQQG
Q-----------------QGQM---------ASGDSNLNFRMVAE-----------IQ--
---------------------NVEGQNLQEQVCPEPIFRFFRENKVEIASAITRPFPFLM
GLRDRSFISEQMYEHFQ----EAFR-N-LVPVTR-VMYCVLSELEKTFGWSHLEA-----
--LFSRINLMAYPDLNEIYRSFQNVCY----EH--SPLQMNNVN---------DLED---
--RPRLLPYGK--QENSNAC----HEMDDIAVPQEA---LSS------------------
---------------SPRCEPGFSS-ESCEQLALPKAGGG--------------DAEDAP
S------LLPGG---GV-SCKLAIQ---------------------IDEGESE-EMPKLL
PYDTE------------V---LE-SNGM---IDAARTYST--APGEKQGEEEGRNSPR--
-----------------------------KRN-------------------QDKEKYQES
PE-GRDKETFDLKTPQV-TNEGE---PEKGL-------------------CLLPGEGEEG
S-D-DCSEMCDGE---EPQEASSSLARC---------------------------GSVSC
LSAE-TFDLKTPQV--------------TN-EG---EPEK--------------------
-------------------E----------------------------------------
-----------------------------LSLLPGEGEEGSDDCSEMCDG-EERQEASSS
LARR-------------GSVSSELENHPMNEEGESEELASSLLYDNVPGA--------EQ
SAYE-------NEKCSC-VMCFSEEVPGSPEAR---------------TESD--------
---QA--CGTM-DTVDIANNSTLGKPKRKR---RKKRGHGWSRMRMRRQENSQQ------
---------NDNSKADGQVVSSE-KKANVNLKDLSKIRGRKRGKPGTR------------
------F-----------------TQSDRAAQKRVR----SRASRKHK-DET-VDFKAPL
LPVTCGGVKGILHKKKLQ--QGI-LVKCIQTEDGKWFTPTEFEIKGGHARSKNWRLSV--
------RCGGWPLRWLMEN---GFLPD--PPRIRYR-----------KKKRILK--SQNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTP----WNCIFCRMKES----
-------PGSQQCCQES-EVLER--QMCPEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHG-----------------YP---QVEGFV
QDMRLIFQN-----HRASYKY-KDFGQMGFRLEAEF-------EKNFKEV----------
------FAIQETNGNN--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------EDQNVDEMLIYETVFSYFSRHKVEISSAIQKTFPFFE
RLRDHKFITDKMFEDSQ----ESCK-N-LVPVPR-VVYHVLCELEKAFDPSILEL-----
--LFDEISMKEYPDLIHIYKSLNKAIQ----DK--VNPQENDEE---------EREA---
--RAGIQLSLE-QGNSNM--------------------------IK--------------
--------------STPSRENGVSE-QLYEKEELNAKREDTTSDKNDALGSQQANTQCVQ
G------SVPT------ESCEQVAVQ-------------------VNNGSARK-EI--PL
PCNEE------------R---ATLSSQG---IQFNPCSVC-----------------LV-
DIKKENP-CSDS--------------EVEQQAKAR----T--------N------HTQ-S
L---EIIVISSEDSEGS-TEEDE---PLVISAAA---------------LTSVPGK----
------------------------------------------------------------
-----------------------------------------------------------K
------------------------------------------------------------
----------------------------------GWRRLSSSDFSELSSG-EETQKTYSS
ILRS------------------------------------------GSGC--------QE
SELK-------ATV----------CVPRRQEAR---------------TESR--------
---QS--SDMM-DTMDIENNSTLEKHSEKRR---KRRKQVYKVNS-LQRG----------
---------------------------------------KKKCRPRSH------------
----LTLNKRVTQK---THQQRGRKSINSEPLKRKR----RRGPRIPR-DEN-IDFQCPQ
LAVTCGELKGTLYKEKFK--QGT-SGKSIQSEHGRWLSPREFEVEGGYAASKNWKLSV--
------RCGGWTLKDLIE-------------------------------QKILK--SPNN
TLVDPC------------------------------------------------------
PENSNVCEVCHKWGRLFCCDTCPKSFHENCHIPPVETEKDP----WSCIFCKTKPIQ---
--------ESQPCYQES-EVLMR--QMLPEEQLKCELLLLKVYCDSKSL----FFAS---
-KPYYS--RKGLWNPKDSMWLNKVKKRLTEKM-----------------YN---QVKGFV
YDMRLIFEK-----HKVYYKK-DKFVRLGVQVQNTF-------EKNFKNI----------
------FAIQETSRNIVMLT----------------------------------------
--------------------------------------------------------

------------------------------------------------------------
-------------------------------------------------------MAQRG
P-----------------RERM---------ASGGRDLGCRVIT----------------
-----------------------EDQNRKQQVSCEHIFKHFRINKVDIASAITKPYPFLM
ILRDHAIISEQMYKHFQ----DTCA-N-LVPVTR-VMYDVLHELEKTFCPSLLKV-----
--LFSRANLQAYPGLREILRSFPNAFH---------------------------------
------------------------------------------------------------
-----------------------------EPLDLQRTNGT--------------DVEELS
R------VALAG---QRVPWEIAVQ--------------------VDEGGESE-EMPRLL
PYDAD------------E------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------N
G-N-NCVEMSETE---ERPEASSSPASH---------------------------GPVSC
-------DPEAPQL--------------MN-GE---AAEE--------------------
-------------------V----------------------------------------
-----------------------------PSHTPHNEEE---------------------
-------------------EPGELQDGPLNEEEESEELTSSPQFHSEQGP--------EQ
SGYE-------AEKCSC-VMCCPK-ISEGPSAS---------------TDSS--------
---QA--CDPA-DTADPGTSSILGKPKRKR---RKKKGYNWSRIKTKRPQSKCQ------
---------KGTQAGTSTM-------HNRATQKRIQSRGRKRGRYQFS------------
----SVLNNRFVRK---TGWLKGRKRVNSKPLRKVR----KKGFRYLK-KTN-ANFDIPK
LPVTCGNVAGTLTKEVFK--QGV-WKKSIRSEDGSLLSPREFEVAGGRASSKNWKISV--
------RCHGWTLRELMQK---EYLPI--PPSKKPK-------------KRTLD------
-----SD-----------------------------------------------------
LRNSNECEVCRDGGTLFCCDTCSRAFHEYCHLPLVEVERNP----WSCIFCTVGSF----
--------KSQEHYQES-EILER--QMQAEEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIKETSEAPKELMWLDKIKTKLTKKE-----------------YT---QVAGFV
QDMRLIFQN-----HRTSYKY-HEFGQMGLRLEAEF-------EKNFKEV----------
------FAIQETNESS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------MA
G------GNNELSSRTIP-----EDQNEEESDDYQLMFKHFKENKVEIASAITKPFPFLM
SLRDRDFISEQKFQEYQ----ETCK-N-LVPVER-VVYDVLSNVQKKFSRDLLKV-----
--IFSKTHLKAYPDLKETLKHFFLNVS---DSH---RTHQRING---------RNVE---
--ER----------PRLPSV----VR----------------------------------
------------------------------------------------------------
-----------------------EAS-------------------KTNDEQAE-EMLSLP
QCNGG--------------E-GSS----------SCEQTC------------------DE
QEPQDDL-PSSLRQEAARRKKRPNWSNSKRRL--QKK------------------KPR--
--QDEMMGVPSPGH-GV-QEKLK-----AVSRRT---------------LWKDD----SS
TN-----------------------VKEVTKTLRARM-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------RCGTCHWKG------------
------------------------------------------------------------
----------------SAWANLSELVQGSRDT----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------FPPRMSSE-----HENTE-TFPFELIFQHFKRQKVAISNAIKNPFPFLE
GLRDHELITAKMYEDLQ----DSYR-A-LVPVDK-VIYRALDELEKTFSMKVLCE-----
--VFSNVNMEKYPDLQLIHQSFEHVLP---NGL---CFHG-------------SDGG---
--DPNSQLSLE-QGPSGSCS----QGS----LTWSH---FDPSSSE--------------
--------------AYKGLNSRK----------TK-----TKTKANRSPS-----HQVPQ
I------PN---------------------------------------------------
---HW--------------K-AVQLNHD---LQINPCSVR-----------------LV-
DIKKENI-SYSLD--------------DNQQTQARTN------------------ENQ--
--GSEIIELSSDEDSND-EINLS-----EASTLI---------------LSK--------
-----------------------------PETAHSRQ-----------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------PPTP-RT-YRR-GDTSDTSSS
SLDRRRKRTGRMLS-------------------------------SSSSELSSGEESEEF
LRSGSGR-LGCPASAHWMAGV---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
----------------------L--------AGDSDSSTXXXXXX---XXXXX-XXXX--
X------XXXXXXXXXXMF-----AEDEEEKRIYEAVLNHFNSHRVEISHAITSTFPFLH
GLRDRGLITDKMFQDAE----ESCF-K-KVPVEY-VVYNLLGTLEK-FDLAFFEA-----
--VFSEVNLKEYPRLVPVREGFENEVN---RAL---QFQTNV-RGHIEGN---SRIQ---
-------LSLE-QXXXXXX-----XXX----XXXXXXXXXX-XXXX--------------
--------------XXXXXXXXXXXXX-XXXXXXXXX-XXXXXXX--------------X
X------XXXX------XXXXXXXXX-------------------XX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXP-GSVSPGPV--MHVNSSPVL-----------------PM-
DIKKERA-CLNS----------------EA--QAGTDC-------------K-----Q--
--ASEIIXXXXXXX-------------XXXXXXX---------------XXX-X----XX
XXXXXXXXXXXXX---XXX-----------------------------X--XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-----XXX-XXX-----------X
XXXX-XXXXXXXXXXXXXXXXXXX----X-------------------------XXX---
------------------------------XXXXXXXXXXXXXXXXX--------XXXX-
XXXXX-------------------------------------------------------
-XXXX--------XXXX--XXXXXXXXXXXXXX----XXX-XXXXXXXXXXXXXXXXXXX
XXXXX--XXXXXXX---------------XX--XXXXXXXXX---XXQRRGQKA------
--------------------------------TINN-----LRGXXXXXXXXXXXXXXXX
X----------XXX---XXXXXXTRRVNNGPLKRGRK----RGRRIPK-YTI-AKFRGPE
LPVECGPMNGTLYKNLLQ--QGS-HQKCIQGKDGRYFTLREFEIEGGYETSKNWKQTV--
------RCLGWPLKVLIQK---GFL QN--PPRRRRKR-------------TQQS--DS-S
IFIDPY------------------------------------------------------
PQNSN ECDVCYQGGVIYCCDSCSRSYHQDCHILHINPESYP----WSCITCRI KTMW---
----HRCWKNQPLRQES-EVLQI--QMQPEEQLRCEYLLLKVYQCSESI----AFAS---
-KPHYG--TQPRQGTQG PMWLDKIKENLRRQE-----------------YS---HVGGFV
QDMRLIFQN-----LKVFCN----------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------FTVSRALEKALLQHFIVQKLEIAYAISKPFPFLE
LLRDKAFISEQMYWDSL----EACR-N-LVPVCR-VVHNILTRLEKTFNLSLLVT-----
--LFSQISLCEYPNLRTILRSFIN---VGT-----AYGEWSRTT---------L------
-----IPLKVL-ADPEE-S---------SFQILRQLPPPQLPSPSHLSCAPAVNEAKASL
-------QHISESLDRPPSPSTPA------------------------------------
----------------------GPLPGLILGEGKMSIPLPFKHHHFQ-------------
------------------------------------------------------------
-------------------------------------------------------SH-LI
FPLS----VIKD------------------------------------------------
----ASSEPNDQE---EPQEAPSTSQKK--------------------------------
----------------------------------------KGKN-F--------------
---------FTSLLGPG-----------------------------ATPPGHRVQEKLQV
VA---KRKDKPAR---NSKLVSRVYNTRAKRAQMSKSEGKAGSGICLGRA-QLG------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------GRVPQ--EWQR---GRQLPEKPK-ENT-VDFLSPM
LPVICGEAKGILYKEKMK--QG-ASEKSIQNEKGAWLSPKEFTVEGKRERSKDWKRSV--
------CCGGKTLRQLMEI-----------------------------------------
------------------------------------------------------------
--------------GILLCPPIKKPQVKNT------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------ESL----QACQ-N-LVPLSK-VVHNVLTSLERTFQPSLLMI-----
--LFSQVNLREYPSLAAIFRSFKN---VRT-----AYEENKRAA---------Y------
-----TLPKAP-TDPAEGH---------SFRTLLPLPPPEPSPPSHLSSAPRVCEPREAS
-------HQITEILDEQPSPSHTA------------------------------------
----------------------VPPPGFIREGKTTAESSRDP--PRNDKDDST-ETPPSP
SGSIP-------------------VK----------------------------------
------------------------------------------------------------
-----------D------------------------------------------------
----ESPAPNDLE---LPQEAPSTPANK--------------------------------
----------------------------------------KAKK-KKR-----------C
IWSTPKRRHQKKRPPQ------------------------VSLGPGVASPGLGVQEKLKV
VGQRTPRKGDSTR---TLKMVTRSQMAKTKRAQTSRSQEVINGASKTNGI-RRPQRMPSL
LPKT--------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------T--QGKSN-DDT-ADFLSPI
LPVTCGKVKGILFKEKMK--QG-PSGKCIQNEAGDLLTPREFLIKGGKARSKDWKKTI--
------WCKGKTLRFLEQK---GLLLC--TSNSNLKK---------------R-------
-----------------------------------------------------------V
T-----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYERQSGDT---------P------
-----ILIEAP-TGLAEGS---------SLHTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSDEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEEDSE-EMPSLL
TSTVP------------------VASDN-----------------------------LIP
HIKDKED------------------------PQQMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKKRHKKKKSLF---------------------------GPDAASPRHGIQKRLKM
VDQVPQKKDDSTW---NSTVVTRVQKARNECARNSRSEEITDDTSKMNEG-KRSQKTPST
PSRVTQ-------------VA---------------------------------------
------------------------------------------------------------
----------------------------------TSPGHGIKE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSVQKAR-TECTQKSRSKG-------------
----------------KTNDEICYL------------------NGKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------HCGGTTLGELLKN-----------------------------------------
-----------------------------------------------------------G
--------------LLLCPPRI----NLKRQLNS---K----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MYEDLL----DSCR-S-LVPVDK-VIYRALEELEKKFDMTVLCE-----
--LFNEVNMEKYPDLNLIRRSFECGNW----VL--YRSLRAQ------------------
------SFLLS-TNVY--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
---------------------M---------AGVGSDLSTRRLNGVVSRVANEMNYLP--
-------AHSQSLQRI-----FTEDQDVDEGLLYDTIFKHFKRHKLEISNAIKKTFPFLE
GLRDRELITDKMFEDSQ----DSCR-N-LVPVQR-VVYNVLSELEKTFNLPVLEA-----
--LFSEVNMQEYPDLIHIRKSFNNAIQ----DK--LSFQES-------------------
------------------------------------------------------------
-------------------------------------DRK--------------EREERP
D------I----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------Q-LSLEQ-EVPESPEAK---------------MENG--------
---QA--CGKM-DTVGIGNNSTLEKPRRKR---KKKKGHSWTRIKSGTQKKIQQ------
---------HDNSKPGG-QLVPNEEKAKVNLQGLSKISGSKRSKNLET------------
----HFS-----------------TQSDRAPNRKGS----DREVKR----------QRK-
-CLSTGNKEGSGSTYPGL--TGS-FLKCIQTEDGNWFTPGEFETKGGYARSKNWKLSV--
------RCGGRPLQRLIEE---GSLPN--PPKIHYR-----------NQKRILK--SHNN
SSVDPC------------------------------------------------------
MRNLDECEVCRDGGELFCCDTCSRVFHEDCHIAPVETERTP----WSCIFCRMKES----
-------SGSQQCCQES-EVLER--QMCPQEQLKCEFLLLKVYCCSESS----FFAK---
-IPYYYYIREACQGLKEPMWLDKIKKRLNEHS-----------------YP---QVEGFI
RDMRLIFQN-----HRASYKY-NDFGQMGLRLEAEF-------EKDFKEV----------
------FAIQETNGNS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------SLCLRMLTE-----------DQ--
---------------------D-TKKKNAEEHFFHEIFMHFKKNKVVMATAIKKTFPFFM
GLRDHCFLSEQKYEHFL----EACA-N-LVPVER-VAYEILTELEKTFDLSLLEV-----
--LFSKVNMKAYPDLIEVYQSFQDGNYTSQL-----PLGIQNRA---------GVTG---
--VNQVIPQRS-PQPGP---------VFAVSKSGLS---LYF------------------
---------------RGEEVPGRRV-RSCLETGRPKPKDG--------------TVKDIH
K------KLHGA---GA-AMLVAVQ--------------------ENERRKSE-EMPRLL
PYDGE------------V---LRSSSL----CGIAIGFPGHVRPTEAQGALRAGRSPL--
-----------------------------KPWK------------------LGSQEYQAD
ITTK--KIEHELKRENF-SADNE---PEYGFL-------------------LNPGRD---
S-M-QSFQPCFPC---SPNKNEKNLI------VR---------------------GSFSC
FSTT-SSELGTPQM--------------NK-EG---DSEE--------------------
-------------------L----------------------------------------
-----------------------------APTLLPHDGQGNDDLEN--------------
--------------------------NKNRKKQAFDKKKKRKDCNVGLGA--------EI
LAPG-------AEKCSH-VMCFSRRVPGAQEAR---------------TESS--------
---QTITCYFL-DTIDTGNNSTLRKQKRKR---RKKKGHSWTRIKRKGQKNIHQ------
---------RDNGKVDGPLVSR-GTKVKVNLQGSAKIWGRKRGRPGIH------------
------L-----------------TRKQKRGQPRDL----SESSRKHT-DKI-VDFHSLV
LPVTCGEVKGTLYKKKLE--KGA-SEKCIQHEDGNWLTPREFEIKGGHARAKYWKLSV--
------RCGGRPLRWLMEE---GFL LN--PPRKYHRR----------KK-RRLK--PHND
NLVGPY------------------------------------------------------
PGNSE ECEVCRDGGQLFCCDTCLRSFHEECHIPPVEVERTP----WSCIFCRM KES----
-------SGSQQCQQES-EILER--EM LPEVQMKCEFLLLKVYCCPESS----FFAN---
-IPYYYYNREDPQVLKEPMWLNKIKKRLSEKG-----------------YH---RVEGFV
QDMRLIFQN-----HRASYKL-KDFGQMGLKLEAEF-------EKNFKEV----------
------FAILETNENS--------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------MFKHFHENKVEIASAITKPFPFLM
SLRDRGFISEQKFQDSQ----ERCQ-N-LVPVSR-VVYDILSDLQNKFSLLLLEV-----
--IFSKTHLKAYPDL---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------S----QH--SPLQRNNVR---------GLEE---
--RN-LLPQDR--QEDSKAC----CEPGDGEEPQEV---SSS------------------
---------------SLGSGAGFCK------QETPRTNGG--------------NCEDLP
D------LLADD---GDVSCELVDLE-------------------RDEGGTSE-EMPTLL
PYDGE------------M------------------------------------------
------------------------------------------------------------
--------TYDSEALQI-NNEGV---LKKAI-------------------SLTASEGEED
S-N-AFWEPYDGE---ETHEALYSSPRL---------------------------EPVPC
FSSV-LCDPETPQM--------------IT-KK---ERDE--------------------
-------------------V----------------------------------------
-----------------------------ASPALCDREXXXXXXXXXXXX-XXXX---XX
XXXXXXX----------XXXSVGIEALQTDREGESEELPSSPLPCDGQGT--------ER
PVGG-------NENYSN-VMSFSKDIPECTEAR---------------TESS--------
---RA--CDTT-EAVDLGSNSILGKLKKKR---VKKRGYSWSRNKKRRQINVH-------
------------------------------------------------------------
----------------------------------------QKGSRKHR-DES-VHFHAEI
LPVTCGALKGMLYKNKLK--KXS-IKKCIRGKDGNWFTPKEFEIKGGYERSKSWKMSV--
------RCGGKPLKWLMEE---GFL PT--PPRIYGR-----------RKQXXXX--XXXX
XSIDLC------------------------------------------------------
QRNSD VCEVCHDGGKLFCCDTCSRSFHEDCHLPPVETERDL----WSCIFCRI KAY----
-------TASQKCNRES-EVLEK--QM GPEEQLACEFLLVKVYCHSESS----FFAK---
-IPYYYYINEASQKLNEPMWLDKIKRRLKEQG-----------------YP---QVEGFV
RDMRLIFQN-----HRAYYKY-NDFGLMGLRLEAEF-------EKSFKEV----------
------FAIQETNENSS-------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEQALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKRMYLESL----EACR-N-LIPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLREYPNLVTIYRSFKR---VGA-----SYERQSRDT---------P------
-----ILLEVP-TGLAEGS---------SLHTPLALPPPQPPQPSCSPCAPRVSEPGTSS
-------QQSNEILSESPSSSDPV------------------------------------
----------------------LPLPALIQEGRSTSVTNDKLTSKMNAEEDSE-EMPSLL
TSTVQ------------------VASDN-----------------------------LIP
QIRDKED------------------------PQEMP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----NSPEPNDPE---EPQEVSSTPSDK--------------------------------
----------------------------------------KGKK-RKR-----------C
IWSTPKRRHKKKSLPRG-----------------------------TASSRHGIQKKLKR
VDQVPQKKDDSTC---NSTVETRAQKARTECARKSRSEEIIDGTSEMNEG-KRSQKTPST
PRRVT-------------------------------------------------------
---------------------------QGA------------------------------
----------------------------------ASPGHGIQE------KLQVVDKVTQR
K---------DDSTWN--------SEVMMRVQKAR-TKCARKSRSKE-------------
----------------KKKE-KDICSSSKR--RFQK---NIHRRGKPK-SDT-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNI--
------RCEGTTLGELLKR-----------------------------------------
-----------------------------------------------------------K
--NSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRML----WSCTFCRMKRF----
-------SGSQQCRHVS-KTLER--QMQPQDQLKCEFLLLKAYCHPQSS----FFTG---
-IPFNI--RDYGEPFQEAMWLDLVKERLITEM-----------------YTVAW----FV
RDMRLMFRN-----HKTFYKA-SDFGQVGLDLEAEF-------EKDLKDV----------
------LGFHEANDGGFWTLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------KKR---------ITPVTNLT--T-HT----
----------------------NDEADS---QQMPSTPST-----------------TM-
QMSSDNLTSQI-K--------------GEEGAQEMCH-------------------AP--
--SASVPVIR--------NDSP---EP---NNAK---------------ELQEA------
--------SSTAP---NKKGKKRKRYSWS--------TPRK-----R--HK-KKSVPR--
------------------------------------------------------------
-------------------------------------------G--TASPGYGIQETLQE
VNQVTQRKNSSTR---NVEVVTRAQKAREECAQTSGLEEVSDDASETNEG-KTSQEPPST
PPRIVQXXXXXXXX-------------------------------XXX------------
---------------X-----XX--XX--XX-----------------XXXX--------
---XX---XX----XXX----XXXXX-XXXX--X-------------X-----X------
--------------------------------XX--------------------------
--------XXXXXX---XXKEREIDVCSSSTRSCQKN---TPQKKKNE-DET-VDFHSPE
LPVTCGEAKGILYKEMMG--KGT-SVKCIENEEGVWLTLREFEIEGRH--TKNWKQSV--
------RCGGMPLAQLIEQ-K---------------------------------------
------------------------------------------------------------
--TS S NCEVCCRGGPLLCCDTCPRAFHKNCHIPSAEAERSP----WSCTFCRM KASS---
----RSRQ----HRRKS-VALAR--RM SPEEQLKCEFLLLKAYCHPQGS----FFV----
-TPRNM--KDYAEPFKEAMWLDLMKERLAEKE-----------------YTMAWFVR---
-DMRLIFLN-----HKNFYKA-SNLSQVGLDLEANF-------EKDLNEL----------
------LIFNEANENSFQSLP---------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------M----------FTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFE
GLLDNSIITKTMYMESL----EACR-N-LVPVSR-VVHNILTQLERTFNLSLLVT-----
--LFSQINLHEYPNLVTIYRSFKR---VGA-----SYEQQSRDT---------P------
-----VLLEAP-TDLAEGS---------SLRTPLALPPPQPPQPSSSPCAPRVSEPGTSS
-------QQSNEILSESPSPSDPV------------------------------------
----------------------LPLPGLIQEGRSTPVTNDELTSKMNEEDDSE-EMPSLL
ASTVP------------------VASDN-----------------------------LIS
QIKDKED------------------------PQETP-------------------HS-PL
GSMP----EIRD------------------------------------------------
----DSPEPNDPE---KPQEVSSTPSNK--------------------------------
----------------------------------------KGKK-RKR-----------C
VWSTPKRKHKKKSLPRALRPTGLPVLPHLKGSPMPFPPEVACGYHDAASPRHGIQKKLKV
VDQVPQKKDDSTW---NSTVVTRVQKARAECARNSRSEEITDDTSKMNEG-KRSQKTPST
PSRVTQEERRKEYG----QSSSK-------------------------------------
-------------------R----------------------------------------
----------------------------------KQKKKLPRE------KLQVVDKVTGR
I---------DDSTWN--------SKVMMSIQKGR-TEGAQKSRS---------------
-------------------------------------------KGKPK-SDP-VDFHCSK
LPVTCGEAKGILYKKKMK--HG-SSVKCIQNEDGTWLTLKEFEMEGKGRNTKNWNRSI--
------RCGGTTLAELLKV-----------------------------------------
-----------------------------------------------------------L
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------MFSIVKNKDISHETLLNLFKQNKVEIANAITKPFPFLE
SLRDRSFITEKIYKDSQ----EAHK-N-LVPVQR-VVYEVLHCLEKTFDRSLLQV-----
--LFSRVHLKEYPDLIHVHRIFENVRE---EKY---FPQKNDNE---------ERQN---
--LPHTGPSSE-QALDKS----------------T----DLRIKER--------------
-------------------KSE-----------------TVCTPLNDGQGF--GGESSEE
EG-------P-----------LEALS-------------------SAGCQGP--------
------------------------------------------------------------
------------------------------------------------------------
----------EEEGED--------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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--------------------------------------------------------

Query Results

"ENSGT00510000046835_0"

ENSGT00510000046835_0