Query Results 

--MATEEKAPAGRDSRFDHA--LLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSR
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFATYE---AYSSWTPQEMAAAGFHFTG-VRAGVQCFCCGLILFGASLHKR
PLDDHKRLRPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGEDVGNVAKYEVRVRKPPGTLRG-DAARYREEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLKSFKDWPF
YAQATAPRELSAAGFVFT--GSRDAAQCFSCG--GCLGNWEDGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYE-GFVGVTGEHFL-NSWVKRV-VPMVSAYSSDS---IFANGEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKNWPPASP-VGAAALAKAGLFYTGVKDVVQCFSCGVCLENWKEGDDPVEDHTKYSP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-GATPDL-QSRDVIPSPT--KSTCESNLADSAAVSSP----A-----
-----------------------------------PEMAQG-EAQWFQEAKG-LSERLRK
A-YTSARFCNT-SLL--EVAPCLATDQLLGCDLSLASKRIGSHVQEPVVLPEVFATLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKRIALLWASGGCPLLNRFQLVFYVSLSSARPDQGLASILCDQLLE
TEDSVTEMSLRPIIQQLKNQVLFLLDDFREMCSVPRVIEKLIQRNHSSRTCLLIGVRRSR
ARAIHRHLHTILEIKAFPFYNSIYILRKLFSHNMIRLRNFMIHFGKNKNLQGIQKTPLFV
VAVCAHWFRHPLD-QSFDDVAVFKSYMECLFLKYK--TTADLLRATVSSCGELALKGFFS
SCFEFRDDDLVEAGVDQDEDLAMCLMSKSTAQRLRPVYQFLSPAFQEFLAGMRLTELLDS
DRQEDRELGLHYLREVNSSLMAVIPY-SNFFNYVSCHASTKAGPKVVSHLLRLVDKKESL
ENILESDDYLKHRPEISVHME-YFRVLWQLSPKYYFSQVSEHLLALAIKIAYQSNALAAC
SPFILRFLQGRTLTFNMLK------SQYFFDHPESLLLLRSIQFSIKGRKS---SRLDLS
VLETCL--DKSQAPTIDQDYASAFEPAKEWEQNLAEKEENVKSFLDMQLNAPPDISTGYW
KLSPKPYKIPLLEVHVTDIDAVDQEMLRVLTAVFSASQHIELHLNDSRGFLESVRPALEQ
YKASFTKCSISRFE-LSAADQELLLTLTSLESLEVSGTTWLRDQLFPNLDKFLCLKELSV
DLDDKQNVFSVIPEDFVNLHHMEKLLIR-IAAEHGPSKLVRLIQNSPDLQVFHLQCNFFS
DFESLMTVLASCKKLKEIK-FSGRFFKAI--PFVIVLPNFTSLKMLNLGHQEFPDRETAE
KFAYTLGSLDNLEELILPTGDAVHQVAKLIVQQCEHLRGLRVLSFYQTLNDDSLMEIVRA
LTSGGGFQKLENLNLSINHKITEEGYRNFFQALDSLPRLQELTISRHFTECIKAQAATVK
SLSQCVSRLPSLIRLNMLSWLLDAEDVTLLTAMKERHPQSKHLTFHWKWILPFSPIIQK-
--

--MAAHGKASEERISVFDHD--FLSELSALLGVDAGQIIKRQQEEDHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLQTFLTYD---TFRSWTPQELAAAGFYFTG-VKLGVQCFCCSLILFCTRLRNL
PIENHKRLRPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYEVRVKSPEK-LRG-GKARYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLESFESWPF
YAHGTPPRVLSAAGFVFT--GKKDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
RSKKSLEEIAQYIKSYE-GFVHVTPLSYPANHWLRRKEYRVEKAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPQESP-VAVEAMVRAGLFYTGE-DVVQCFSCGGFMEQWKEGDDPLEDHTRFYP
NCVF-LQYLKSSA-EVTPAL-QSQCEIPEAM--VMDTTPSV-------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SREDAG-----------
--A---------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------FLS------------------
---------------------------------TVAGENLKAGPKIVSHLLQLVSDKESL
ENLSENEDYGMLHSKTSCVIQ-LIKEMWQVSPEAFSLFISEHLLNVALKFAYESNVVAAC
SPFILQFLRGRTLALKVLN------LQYFGDHPESLQLLRSVQVSINGNKM--LPRVGYS
VMEKCF--ENLQPPTIDEDYASTFEHMKEWEKNLAKNEDNLRNFMNNQPQCLPNISAGYW
KLSPRQYKIPRLEVGVVNMGPADQALLQVLMEIFSASQDIELCLTHSSDFLESIRPALEL
HKTSVTKCSLCRLR-LSAAEQQLLLTLPALRSLEVSGTKQLPDQLFANLDKFPNLRELSV
RLDGIPDVLSVFPGDLPNLHHMEKLSIQ-TSTESDLSKLGKDGAWISQVMVQ--------
--------------LEKMS-RSSAAHE----------------------GTTTEGGFVVS
PTAQALGSLGNLEELLLPTGDGIQQVAKLIVQQCLQLPCLRVLAFTETLDDDSVMEIAKG
-ATSGGFQKLETLDLSMNHKITEEGYRNFFQALDNLPNLQVLNMCRSIPERIQVQATTVK
ALSQCVSRLPSLTRLEILSWLLDEEDMKVINAVKARHPQSKRLMVSWKWIVPFSPVFQK-
--

--MASAEEAPEEKTSRHEYG--LLSALSGFLGTDLVQLRKEVDEEQHRARKEVKKGFNAY
MRNEEK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFMTYN---LDSCWTPQEMAAAGFYFTG-IKSEIQCFCCSLILFDTNFWKL
PLGEHKKFHPDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNISKYDVRVKSPACELKG-DKAKYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 268)

RLESFQTWPF
YVQGIPPQELSAAGFAFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEH----------
------------------------GEH

ENSGT00500000044782_2_Linker_1_2 (268, 300)

FV-NSWIQRE-LPMASAYNSDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKNWPHKFS-SKVSLLAKAGLIFTGESDIVHCFSCGLCMEKWKEDDDPLKDHIKYSP
RCEF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QSKKSSE-EI-KVL-QNHAATRLRH--ECE------------------------
-------------------------SSCASSLSLSTEEAPR-ETQCLQKAKR-LSEQLRA
A-YIKASFRHM-SLL--GISPNQPTDRLLGCDLSIVSKHISSPAQEALMMPEVLANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 687)

I
MCVEGEVGSGKTVFLKKIAFLWASGCCPLLNRFQLVFFLSLRPTGQDRGLANIIHDQLLD
KEDALTEECLRNIIQQFKNQVLFLLDDYSEMYSIPQAIQ-MILRNHTSRTCLLIATHRNR
TRDIRQYLHTVLDIQDFPFYNTVYILRTLCPYNFIRLLKFYVYFEKNQDVQGILKTPLFV
AAIWANWSQYPLH-LFFDDVAVFKSYMEHLSSRDQ--TNNESLKATVSSCGQLALKGLFA
SRFEFDVDDLREAGLDGDGSLTTCFMSKFTAQRLRPVYRFLNPAFQEFLAGMKLIELLDS
DRQEEQELGVSYLKEINSSLKAVFLY-KKFLIYVSSQPSTKVGPKLVSHLLQLVDHNESL
ESVSEKDEYLQIQLESSPCMQ-LMWDMWKIYPETFFAYASLRLLDLALKVACQSSTMATC
SLFFLQFFQGRTLGLEELA------SEYFFDYPESLLVLKSIKVTLNGKEP--PPWLCLP
DLERCY--DKSQIPAVDADYAAAFESMKEWEQNIAEKKETIHKHLSRRLTKAPRLCGGYW
KLSPPPHKIPLLEVHVSNMDAADQEMLRVLMTAFSVSQRIELHLTNSTSFLESIRPALEQ
HRTSVTRCSIDRFE-LSTAEQELLLSLPFLESLDISETVQLQDQILANLDKFPCLKELSV
KLDNQRDVFSVIPEEFSKLHHMEKLWIQ-IFSEKDSSKLVKLIQNSPDLRVFYLKCYV-L
DFESLMNALVSCKKLEEIQ-FSGRCFEVT--PFVTSLPNFTSLKILNLNLQYFPDKETSE
KFASALGSLTKLEELNLPTGDGIQQVAKLIVQQCQQLPCLRVLSFFQTLSDDSIMEI---
------------------------------------------------------------
------------------------------------------------------------
--

--MATQQKASDERISQFDHN--LLPELSALLGLDAVQLAKELEEKEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAAAGFYFTG-VKSGIQCFCCSLILFGASLKRL
PIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEARLASFRNWPF
YVQGISPCVLSEAGFVFT--AEFMEAQRL-------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

--MASQEEAADQRISQYDET--TIPQLSALLGIDMVQFVKEIEKKEQEDREKMQKGFNSE
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 136)

RLKTFVTYD---SYSSWTPQEMAAAGFYFTG-IKSGVQCFCCSLILFCTTLKRL
PLEHHKKFSPHCEFL

ENSGT00500000044782_2_Linker_0_1 (136, 171)

LGKDVGNIAKYDIRVKNPESKMRG-DKAKYREEKA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFHDWPF
YAHGTSPRELSAAGFVFTDAGKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDVTGEHFV-KSWVKRD-LPMASAFCNDS---IFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LESFKKWPHAFP-GGAAALAKAGLFYIGIEDTVQCFSCGGCMNNWVEGDDPLGDHSRYFP
DCLF-L

ENSGT00500000044782_2_Linker_2_3 (367, 539)

QNLKASA-EVIPDL-QSHDELSELT--ETISETSLEDSAAVSSL----VP--GK
DFEIAHGIIYRVPPQNNKGDFKRERICVCASFLLSTETAQS-EAQWFEEAKS-LNQRLKE
A-YTDASFRRM-YML--EVSSSLATDHLLSCDLSLASKHISTPVQKPVLLSDVFANLN

PF05729 // ENSGT00500000044782_2_Domain_3 (539, 693)

SV
MCVEGEAGSGKTVLLKKIALLWASGCCPLLNRFQLVFYLSLSSTRLDQGLANIICDQLLE
TEGSVTEMSLRNIMQQLKNQVLFLLDDYKEMCSVPQVIQKLIHKNHSSRTCLLIAVRTNR
TRDIRQYLHTILEIKAFPFYNTVYILRKFFSHDLTRLQKFMIHFKMNANMQGIQKTPLFV
AAVCANWFRNPFD-RSYDHVTVFKSYIECLSLKHK--LSAERFKANVSSCGKLALKGFFS
SCFEFSDDDLVEAGVDEDEDLTMCLMSKFTAQRLRPVYQFLDPAFQEFLAGMGLIVLLDS
DRQEDQDLGLYYLKQIHSSMMTLSSC-NNFLTYVSCYPSTKAGPKIVSHLLHLLDNKKSL
ENLSEKDD-LKHHPEVSESVH-LYRSLWQLSPEDCFSLVSKHLLTFAIKIAYQSNTVEAC
SPFILQFLQGRTLTLDMLN------LPYFFDHPESLLLLRSIKVSVTGNMKIMSPVSDSS
CLERCW--DKSQAPTIQQDCAAAFEDMMEWEQNIVEKQKDILRFMSMIVKAPPDISTGYW
KLSPKQHKIPLLEVHVTNMDGVDQETLRVLMAVFSASQHIELHLRGSRGFIESLRPAIEQ
YKASFTKCSINESE-LNAVEQELLLNLPSLESLEVSGTTQIPDQLFPNLDKFPCLKELSV
NMD-KKNVFSVIPEEFLNLHNMKKLLIE-ISAENGPSKIVKLIENSPNLNVFHLQCNFFS
DFESLLTVLASCKKLKEIK-FSGAFFKPI--PFVTILTNFISLKILDLKFQEFPDKETSE
KFAHTLGSLSNLEELILPNGDGIHQVAKLIIQQCQHLRCLRVLSFFKTLNDDSVMEIAKV
-AISGGFQKLENLDLPLNHKITEEGYRNFFQVLDNLPNLQELTISRHYTECIRAQATTVK
SLSQCMLRLPSLTTINMLSWLLDAEDITLLTSTKEKHPQSKLFNIHWKWTLPFSPIIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDQQKVQATMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 192)

LLNKDVGNIAKYDIRVKNLRSRLRG---------------------
-----------

PF00653 // ENSGT00500000044782_2_Domain_1 (192, 241)

EAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITAEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QRPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFGKNGSLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQNLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQMCPQAYFSMVSEHLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRFDSS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKENNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNDIDAVDQEMLEILLTVFSASQRIELHLNHCGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MATQQEASDERISQFDYD--FLPELSAILGIDAVQLAKEMEEDQQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGTSLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLGSRLRG-GKMRYQQEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRNWPF
YAQGISPPVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESE-VGAAALAKAGLFYTGIKDIVQCFSCGRCLEKWQEGDDPLEDHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLTTDHLLGCDLSIASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVNIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VTAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEHLLVLALNIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSIKGNKT--SPRFDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRRAPPDLSTGYW
KLSPKQYKIPCLEVHVNGIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLELSGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTALASCKKLTEIK-FLDSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFQALDNMPNLQELNISRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

------------------------------------------------------------
------------------------------------------------------------
---------------------------MRTVVTSGDPLR-GT------------------
-------AGQMRCFPVST--G

PF00653 // ENSGT00500000044782_2_Domain_1 (202, 241)

DRDTVQCFSCG--GCLGNWEEGDDPWQEHAKWFPKCEFL
QSKKSSEEISQYIQSYQ-GFVDVTGEHFV-NSWVRRE-LPAASAYDSDS---IFTNEELR
WDTFKNWPRASL-PTVEALVKAGLSYR---------------------------------
------------------------------------------------------------
------------------------------------EVAQG-EAPWFREAKN-LSEHLRA
T-YTSALFLHL-PLL--EGPPELPTDHLLGCDLPLVAKRFSSPVQEPLTLPEVLANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MSVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTSPDQGLAQIICDQLLA
KEGAVSETSLRSIIQQLGNQVLFLLDDYRARGSAPQLIETLIQRSHLSRTCRLIAVRTNR
ARDIRRHLDTVLEVRAFPFYNTLSILWRLFPHDLPRLRKLMVHFGKNMHLLGIHKTPLFV
EAICAYWFRYPFT-QSFDHMAVFKAYMECLFIKYK--TPDELFRATVSSCGELALKGFFS
SHFEFSADDLEEAGVDEDEDLTMCLMSRFTAQRLRPVYKFLNPAFQEFLAAKRLSELLDS
DTQEDQDLGLYYLKQINSPMLAVSSY-YNFLKYVCSYSSTKVGPNIVSHLLHLADSKESL
EYLPRNGDSLKHEEEMPLDTQ-AIRLLWQLCPEQCFLLLSEFLLDFALMIAYESSTVATC
APFISHFLQGRSLPLKVLN------SQYFFDYPESLLVLRSITISIKGSKLR-CI-SDNK
ILERCF--DRSQAPTVDQDYASAFETLNEWAQDLAEKEKTISSYLNLKVWHPPDISGGYW
KLSPKPHKLPLLQVHIVDESTASPEVLAVLTEVFSASQHIELLLEGSSGFMENIRPALEL
NKAAVTKCILH-GVQLSAAEQELLLALPALQSLDISGSVQLQDQIFPNLDKLPCLRELFV
NLDSRLDVFSLLPEEFANLHHMEKLLIQ-ISAGCDASKLVKSIQNSPNLRIFHLKCYSFS
DFESLVTTLASCKKLEEIK-FSGPFFKAT--PFVTILPNFTFLKILNLEHQQFPDKETSE
KFACTLGSLTHLEELVLPTGDEIYHVANQIIQQCQQLLCLRVLSFFQILNDDSVVEIAKV
-AISGGFQKLEDLNLSINHRITQDGYRNFFQALDNLPSLRELNVSRNFTECIVAQARTVK
ALGQCLCRLPSLLTLNMFGWLLDAEDITLLDAVKERCPQSKRLHIFWKWRLPFSPIIQK-
--

--MATHGEASEERVSEFDYD--FLPELSALLGMDAGQLVKSQEEENHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRSWTPQEMAAAGFYLTG-VKLGVQCFCCSLILFGTNLRKI
PIERHRELRPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDVRVKSPEK-LRG-DKARNQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRR-ELPVVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHNSP-GAVEALVRAGLFYTGIRDIVQCFSCDGCMENWKEGDDPLEDHTKFYP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QYLKSSA-EVTPAL-QSHCEILKAM--DTTGGSNHEDPVTVLSTV---------
-------------AD----------------------LAQS-EAQWLQEAKS-LSEQLRA
A-YTKATFRHM-NLP--EVCSSLGTDHLLGCDLSIISKHISRPVQEALTLPEVFTNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 690)

V
MCVEGETGSGKTTFLKKTAFLWASGCCPVLNRFQLVFYISLSSSRPDQGLASIIGAQLLE
AGGSISEVCLSSSIQHLKHQVLFLLDDYSGMDSLPQAIETLITKNYLSQTCLLIAVHTNR
ARAIRPYLDTILEIKEFPFYNTITVLRKLFFHKISCLLEFMVYFGMNEDLQGIHKTPLFM
AAVCTDWFQNPSD-QSFHDVAVFKSYMKYLFLKHE--ATPGPLKATMSSCGQLALRGLFS
SCFEFSSEDLTEAGVDEDEDLTTCLMSKFTAQRLRPVYRFLSPLFQEFLAAMRLTELLGS
EREEDQDLGFEYLRQVNSPLKALSVY-NNFLKYVSSHPSSKAGPKIVSHLLQLVSDKESL
ENMSENEDYGKTQPKTSRMMQ-LIKGMWQVSPEAFSLFISEHLLSIALNFAYKSNSVAAC
SPFILQFLQGRTLNLKVLN------LQYFGDHPESLLLLRSVKVSINGNKM--PPRVGYS
VMEKCY--ETLQPPMIDEDYASTFEHMKEWEKNLAENEDKLRNFMNNQPQCPPNISAGYW
KLSPKQHKIPRLEVGVTNMGPADQALLRVLMEVFSASQDIELHLMHSSGFLESIRPALEL
NKTSVTKCSLCRLR-LSAEEQQLLLALPALRSLEVSGTNQLPDQLFPNLDKFPSLRELSV
RLDGSPDVLSVIPGDLPNFHHMEKLSIQ-TSTESDLSKLVKLIQNSPNLHVFHLKCDFFS
DFESLMTVLASCKELREME-FSGRCFETR--PFVTILPNFVSLKILNLECQQFPDKETSE
KFAQALGSLRNLEELLLPTGDGIQQVAKLIVQQCLQLPCLRVLVFHHILDDDSVMEIAKG
-ATSGGFQKLETLDLSVNHKITEEGYRNFFQALDNLPNLQVLNICRSLPERIQVQATTVK
ALSQCVSRLPSLTRLEILSWLLDEEDMKVINAVKERHPQSKRLTVLWKWIVPFSPVIQK-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------MYQQWAE--

PF00653 // ENSGT00500000044782_2_Domain_1 (201, 241)

GKRDTVQCFSCG--GSLGNWEEGDEPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQGYK-GFVHVTGEHFV-KSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDMFKDWPQESP-VGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFP
ECVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPTL-QSQYALREAM--ERTSESNHDDAAAVHSTVV--------
------------------------------------DLGRS-EAQWFQEARS-LSEQLRD
T-YTKATFRHM-NLP--EVCSNLGTDHLLGCDVSIISKHISQPVQGALTIPEVFSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLG
AGGCISEVCLSSSIQQLQHQVLFLLDDFSGLASLPQALHTLITKNYLSRTCLLIAVHTNR
VRDIRPYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVGKLILYFIDNKDLQGVYKTPLFV
AAVCTDWIQNASAQDNFQDVTLFQSYMQYLSLKYK--ATAEPLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEKLTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLSELLSS
DRQEDQDLGLYYLRQIDSPLKAINSF-NIFLYYVSSHSSSKAGPTVVSHLLQLVDEIESL
ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESFSSFVSEHLLRLALIFAYESNTVAEC
SPFILQFLQGRTLALRVLN------LQYFRDHPESLLLLRSLKVSINGNKM--SSYVDYS
F-KTYF--ENLQPPAINEEYTSSFEHISEWRRNFAQDEEIIKNYENIRPRALPDISEGYW
KLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFCLFDSSGFLESIRPALEL
SKTSVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLP------------------
---------------------------------------VKFIQNFPNLHVFHLKCDFLS
NCESLMAVLASCKKLREIG-FSGRCFEAM--PFVNILPNFVSLKILNLKDQQFPDKETSE
KFAQALGSLRNLEELLVPTGDGIHQVAKLIVQQCLQLPCLRVLTFHNILDDDSVIEIARV
-ATSGGFQKLENLDISMNHKITEEGYRHFFQALDNLPNLQELNICRNIPGCIQVQATTVK
ALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVVLE-
--

--MAEYGESSEDRISEIDYE--FLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFETYD---TFRSWTPQEMAAAGFYYTG-VKLGVQCFCCSLILFGXSLRXL
PIERHKKLRPECXF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDIRVKSPEKMLRG-GKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GSLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQGYK-GFVHVTGEHFV-KSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDMFKDWPQESP-VGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFP
ECVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPTL-QSQYALREAM--ERTSESNHDDAAAVHSTVV--------
------------------------------------DLGRS-EAQWFQEARS-LSEQLRD
T-YTKATFRHM-NLP--EVCSNLGTDHLLGCDVSIISKHISQPVQGALTIPEVFSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 688)

V
MCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLG
AGGCISEVCLSSSIQQLQHQVLFLLDDFSGLASLPQALHTLITKNYLSRTCLLIAVHTN-
---------------------------RFFSHDIICVGKLILYFIDNKDLQGVYKTPLFV
AAVCTDWIQNASAQDNFQDVTLFQSYMQYLSLKYK--ATAEPLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEKLTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLSELLSS
DRQEDQDLGLYYLRQIDSPLKAINSF-NIFLYYVSSHSSSKAGPTVVSHLLQLVDEIESL
ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESFSSFVSEHLLRLALIFAYESNTVAEC
SPFILQFLQGRTLALRVLN------LQYFRDHPESLLLLRSLKVSINGNKM--SSYVDYS
F-KTYF--ENLQPPAINEEYTSSFEHISEWRRNFAQDEEIIKNYENIRPRALPDISEGYW
KLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFCLFDSSGFLESIRPALEL
SKTSVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHNFLGLKELCV
RLDGKPDVLSVLPGEFPNLHHMEKLSIE-TSTESDLSKLVKFIQNFPNLHVFHLKCDFLS
NCESLMAVLASCKKLREIG-FSGRCFEAM--PFVNILPNFVSLKILNLKDQQFPDKETSE
KFAQALGSLRNLEELLVPTGDGIHQVAKLIVQQCLQLPCLRVLTFHNILDDDSVIEIARV
-ATSGGFQKLENLDISMNHKITEEGYRHFFQALDNLPNLQELNICRNIPGCIQVQATTVK
ALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVVLE-
--

--MATPKQAPQERISQFDYA--WLSEVSPLMGLDAISFAKNLEEEEQSYRVTMQKGYNAQ
MRSEAR

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFETHP---QDGSWTPQEMAAAGFYFTG-VKTGIQCFCCSLILFGTSLRRV
PIEDHKTFHQDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLSRDVGNIGKYEVRVKSPEKKLRR-DKARYKEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFKNWPF
YAQATSPRALSAAGFVFT--GERDTVQCFSCS--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QRKKSSEEIAQYIQSYK-GFVDVTGEHFM-NSWVKRE-LPMASAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKNWPQESS-AGVAALAKAGLFYTGIKDIVQCFSCGGCLENWKEGDDPLEDHTKYFP
NCQF-I

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVIPGL-QNHVELCELM--ESTSESNLEDSAADSSI----LP--GK
KLEVAYGFYVCRK--LNVTETVEGPKTSLAPFLLSTEMAQG-EPQWFQEAKS-LNEHLRA
A-YLNASFRRL-SLL--EISSGLATDHLLGCDLSIVSKDISNLVQEPLVLPEVFTKLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTIFLKKIAFLWASGCCPFLNRFQLVFYLSLSATRPGQGLADIISDQLLE
KEGSVTEMCLRNIIQQLRNQVLFLLDDYKEMGSVPQDVERLIQKNHSSRTCLLIAVRTNR
ARDIRRYLDTILEIKAFPFYNTICILRKLFSHNMARLLKFRIYFGRQKNLQESHKTPLFV
AAVCANWFQYPFD-PSFDDVAVFKSYMECLFLRHK--TTIELLQATVSSCGELALKGFFS
SCFEFSDDDLEEAGVDEDGDLTMCLMSKFTAQRLRPVYQFLSPPFQEFLAARRLIELLDS
DRQADQDLGLYYLKQINSSMMALKPY-NNFLNYISNCPLTKAGPKIVSHLLHLVDDKESL
ENVSENDDYLKHRPEISQEMV-FIRRFWQMAPQAYFSLVSNHLLGLALKIAYQSNTVAAC
SSLILQFLQGRTLSLDVLK------LQYFFDYPESLPLMRSIQVSIRGNKH--PRRADFS
VLETCL--DKSQAPTIDQDYTAAFQPMKEWEQNLAEDEDMVESYMAIRHTAPPDISTGYW
KLSPKQYKIPLLEVHVTNADAIDQEMLKVLMTVFPASQHIELHLTHSSGIIESIRPALEL
HKASVTKCSIDKCE-LSVAEQELLLTLPSLESLELTGTIQVLLQSYYSFYVYLYKYPYCV
NVKHKCRDIRLLNLKVTFLSVNENLQSS-LISENPSYFTVRLIQNSPNLHVFHLKCNFFS
DFESLMTVLSSCKKLKEVK-FSGSFFQSI--PFVAILPNFISLKILNVGNQQFPDKETSE
KFAYTLGSLKNLEELILPTGDGIHQVAKLIVQQCRQLQRLRVLSFFQTLDDDSVMEIAKV
-AVDGGFQKLENLNLSINHKITEEGYRNFFQALDNLPNLQELSITRNYTHCIKAQATTVK
SLSQCVLRLPSLTTLHMLSWLLDAEDIALLNVMKERHPQSKHLNIFWKWILPFSPIIQK-
--

--MATQQKASDERISQFDHN--LLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAAAGFYFTG-VKSGIQCFCCSLILFGAGLTRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLASFRNWPF
YVQGISPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
RSKKSSEEITQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPRESA-VGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVTPDL-QSRGELCELL--ETTSESNLEDSIAVGPI----V-----
-----------------------------------PEMAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLE
KEGSVTEMCVRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNR
ARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFV
AAICAHWFQYPFD-PSFDDVAVFKSYMERLSLRNK--ATAEILKATVSSCGELALKGFFS
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYHLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLQMQ-LLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAAC
SPFVLQFLQGRTLTLGALN------LQYFFDHPESLSLLRSIHFPIRGNKT--SPRAHFS
VLETCF--DKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSV
DLEGNINVFSVIPEEFPNFHHMEKLLIQ-ISAEYDPSKLVKLIQNSPNLHVFHLKCNFFS
DFGSLMTMLVSCKKLTEIK-FSDSFFQAV--PFVASLPNFISLKILNLEGQQFPDEETSE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKV
-AISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQATTVK
SLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MAEHGESSEDRISEIDYE--FLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 136)

RLKTFETYD---TFRSWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFGNSLRKL
PIERHKKLRPECEFL

ENSGT00500000044782_2_Linker_0_1 (136, 171)

QGKDVGNIGKYDIRVKSPEKMLRG-GKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GSLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQGYE-GFVHVTGEHFV-NSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDTFKDWPHESP-VAVDALVRAGLFYTGKKGIVQCFSCGGCMEKCTEGDDPIQEHNKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTPKSSA-EVIPAL-QSHCALPEAM--ETTSESNHDDPAAVHSTVV--------
------------------------------------GLGRS-EAQWFQEARS-LSEQLRD
N-YTKATFRHM-NLP--EVCSSLGTDHLIGCDVSIISKHISQPVQGALTIPEVFSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLG
AGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNR
VRGIRSYLDTSLEIKEFPLSNTVYILKKFFSHNIKRLLEFMVYFGQNEDLQGIHKTPLFV
AAVCTDWFENPSD-QPFQDMALFKSYMQYLSLKHK--GAAKPLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSS
DRQEDQDLGLYYLRQINSPLKALTTY-NNFLKYVFSHPSSKAGPTVVSHLLHLVDETELL
ENTYKNEDYVNHPPGTSRIMK-GLKELWLLSPEYYSSFVSEHLLRIALNFAYESNTVAEC
SPFILQFLRGRTLALKVLN------LQYFRDHPESLLLVKSLEVSINGNKV--PKVVDYS
VMEKSF--ETLQPPTIDQDYASAFEQMKEHEKNLSENEETIKSIKNIFPLQPPKISSGYW
KLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPALEL
SKASVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCV
RLDGKPDVLSVLPGEFPNLLHMEKLSIR-TSMESDLSKLVKLIQNSPNLHVFHLKCDFLS
NCDSLMAVLASCKKLREIE-FSGRCFEAM--PFVNILPNFISLKILNLISQQFPDKETSE
KFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHYILDNDSVIEIARV
-ATSGGFQKLEKLDLSMNHKITEEGYRNFFQALDNLPNLQNLNICRHIPECIQVQATTVK
ALGQCVSRLPSLTRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKWIVPFSPVVLE-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------ERTQG-EAQWLWEAKS-LSEQLTA
A-YTDATFRRM-TLL--KVSSSLATDPLLGCDLSIVTKHVSSPTQEPVALHEALATLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 690)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLGSTRPDQGLASIICGQLLG
TEGSVTKMCLRTIIQQLKNQVLFLLDDYKEMCLLPQVIEKLIQKNHLSQTGLLIAVCTNR
ARALRHYLDRTLEITVFPSYNTIYVLRTFFLHNRSHLQRFMVHFRMNEDLQRIQKTPLFV
AAVCADWFRRPFH-QSFDDDAVFKCYKECLALKHS--ASAELLKATVSSCGELALKGFFA
SCYEFDGSELTEAGVDEDDDLTMSLMSRFSAQRLRPVYRFLNPAFQEFLAGTRLIELLDL
D-QEDQDLGLFYLRHIDSSIMAVSPY-GNFLNYISNRTSTKVGPKILSHLLQLMSNEASL
EIISENNDYAKQHPRMSEKMQ-IFRSLRQVSPQAYFSLVSEHFLTLALKITYQSDTVVAC
SPFILKFLQGRTLTWKVPQ------LQYFFDHPESLLLLRRVKG---------EPRPDFS
VMAACL--DKSQAPTIDQDYTSVFEPMKEWEQELAEKEESLKNFLKSSARHHR-TSEPAT
GNSPKQPKIPLLQVHVTRANAVDQDTLRALTAALSASQHIKLHLSHSRGFIESIHPALEP
CKASVTKCSIGNAE-LRTAEQELLLTLPSLASLHVTRCFRSLYQVFPNLDKFL-LKELSV
NLQGNLNVFSVLPEDSASFHQMEKSLVR-VSAECDPSKLVKMIQNSPNLHVFHLKCDFFS
DFESLKTALASCKKLKEIV-FSGPFFEAI--PFVTILPNFISLKILNLEFQQFPDQETSE
KFDYCFYSISH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

--MAAQEAAQEDTVSGFDFA--LLPELSPFLGIDAVQFAKEMEEGFQKEREKMQKGFNSH
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKSFVTYE---HYSSWTPQEMAAAGFYFTG-IKSGIQCFCCSLILFGASIHRL
PIELHKKFRPRCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNVGKYDIRVKNPENMLRG-DKARYQEDSA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFQNWPF
YVQAVSVRDLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPTCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVGVTGEHFV-NSWVKRE-LPMVSAYCNDS---IFANEGL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKSWPHAFP-AGVSALVRAGLLYTGMKDIVQCFFCGGCMENWKEGDDPLDDHAKYFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNLKSCA-EGIPDD-HNHCELSELT--DTTSESYGEDSAAVSSV----V-----
-----------------------------------PAAAQG-EAQWLQEAKN-LSEQLRE
S-YTSASFRHM-CLL--EASPSLATDHLLGCDLALALKHISSPVEEPVVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEASSGKTVLLKKIALLWASGCCPLLNRFQLVFYLSLSSTRLDQGLATIICDQLLK
TEGSVTETCLRNIIERLKNQVLFLLDDYREMCSVPQVIEKLIQKNHS-RSCLLIGVHTNR
ARDIRRYLDTILEIKVFPFYNTMYLLRKLFSHDMSCLRKFMVYFRMSENLRGIHKTPFFV
TSLCANWLQYPLN-KAIDGVAVFKSYIECLFLKHK--SEAELVRATVSSCGELGLKGLFS
SCFEFSDDDLTEAGIDEREGLVSCLLSKFTAQRLRPVYQFLNPAFQEFLAGKRLIELLDS
DRQEDQDLGLSYLKRINSSVTAVGLY-STLLNYLSCHPSTKAGPKIVSHLLHLADSKESL
EIILKNNNYLKHHPEISEKLE-CMRSLWQVSPESYFSIISNQLLSLALKIAYQSHTVAAC
SPFILQFLQGKTLNLDVLN------LPYFFDHPESLLVLRSIQVSIRGNEV---HTLDLS
ILETCI--DKSQAPTVDQDCVSAFESVSAWKQDIAEKEENIKHFQNLRLAKLPDISSGYW
HLSPKQYKIPLLEVHVSGGATVNQEMLRVLTVIFSASQCIELHLQNSGEFMAGISPALEQ
SKDSVTKCSVFCLE-LSTAEQELLLTLPALESLQVLGTRQVPGKLLTNLDKFLCLKELSV
DLRHQQNVFALIPEEFFNLRHMEKLLIQ-ISAEYSPSKLVKLIQNSPNLHVFHLQCNFIS
DFESLMTALSSCKKLKEIN-FSGSFFTPI--PFVTALPNFISLKILSLKNQQFPDKETSE
KFAYTLGSLNNLEELELPTGDGIQQVAKLIIQQCQHLQFLRILSLCQILDDDSVMEIAKV
-AIDGGFQKLEDLNLSVNHKITEEGYRNFFQALDNMPHLKELTISRHFTECIKAQATTVK
SLSQCMSRLPSLIRLNMLSWLLDTEDITLLTAMKERHPQSKRLFIHRKWVLPFSPIVQE-
--

--MSAL-GEAEERISQFDYS--LAPEMSALLGVDALAFMKLREEKEHRERARMRKSFNPR
MRSEAR

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLRTFATYH---PYSSWTPQDMAAAGFYFTG-VKSGVQCFCCSLILFGCSCRKV
PVEHHREFRPGCPF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGRDVGNFSKYDVRVKTPGKEPSG-GRARYREQEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLASFENWPF
YVHAVSPRGLAASGFVFT--GHRDTVQCFSCG--GCLGNWEEGDDPWQEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYQ-GFVGVTGEHFV-NSWVKRE-LPMASAYDNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
RDTFKSWPGKSP-VAVAALVKAGLFYRGVEDEVQCFSCGGCMKNWQEGDDPLADHTKYFP
SCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVIRDL-KGCGELPEIM--ETTGESKLED----------P------
----------------------------TTASSLMPEVAQQ-EAPWFAEAKS-LSEQLRA
I-YTSARFRHL-SLL--ESPSDLPSDHLLGCDLALTAKHVSSPVQEPLTLPEVLANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 691)

V
MSVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLDSISPDQGLAQVICDQLLA
TEGTVSETSLRHMTRQLGNQVLFLLDDYRARASGSLVMETLIHRSHLSRCCRLIAVHTNR
GRDIRQHLDTVLEIREFPFYSTFSVLRRLFPGHQPQLRKLLVCFGKNPHIQGIYKTPLFA
VALCAYWLRYPFT-QSLDHVAVFKAYMECLFLKHK--TQAELFRATVSSCGNLALKGFFS
SRFEFSDDDLAEAGVDEDEDLSMYLMSRFTAQRLRPVYQFLNPAFQKFLAGKRLSELLDS
DRNEDQDLGLYYLKQINSPLLAVCSY-HDFLKYVSSYPSTKVGPKMVSHLLHLASK-ESL
GHPPPNSDPSKQEEEMSLDAQ-MFRSLWQLCPEQCLLLLSEFLLDFALSIAYQSSTVAVC
APFILKFLQGRSLPLRVLN------SQYFFDYPESLQVLRSITVFLIGSKQR-CR-PDSE
ILERCF--DRSQMPTIDEDYASAFETLQQWEQDLALKEENIRSYQRLQLQPPLVLSSGYW
RLSPRPHQLPLLQLRAAYQGAASPAVLQALTAAFDAAQHVELHVEKSSGFLESIWSALEP
SRAAVTKVTLCIDEWLSATEQELLLALPALESLAISGSAKFSDQIFPNLDKFPCLRELSV
NMDSSLDIFSLFPDEFPNLHHMEKLLIQ-VSAGCDASKLVKLIQNSPNLCVFHLTCNFYP
GFQSLMTTLASCKKLSEIR-FSGSFFDAV--PFVTILPSFSFLKILNLEYQRFPDKETAG
KFAGALGSLANLEELVLPTGDEIYQVAKRIIQQCQRLTCLRALTFFKILNDDSLAEIANI
-AISGGFQKLEDLNLSGNHKITQDGYRNFFQALDNLPSLRELNISRHFADCLTIQATTVK
ALGQCMSRLPSLLHLNILGWLLDAEDVALLDAVKERHPQSMRLQISWKWRLPFPPVIQK-
--

--MAAQGEAVEEIICEFDDD--LVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFETYD---KFRSWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFSTRLRKL
PIENHKKLRPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDIRVKSPEKMLRG-DKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSPEEITQYVQSYE-GFLHVTGEHFV-NSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDTFKDWPHESP-GAVEALVKAGLFYTGKRDIVQCFSCGGCMEKWAEGDNPIEDHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPAL-QSHCALPEAM--ETTSESNHDDAAAVHSTVVDVSPSEAQ
ELEPASSLVSVLCRDQDHSEAQGRGCASSGTYLPSTDLGQS-EAQWLQEARS-LSEQLRD
T-YTKATFRHM-NLP--EVYSSLGTDHLLSCDVSIISKHISQPVQGSLTIPEVFSNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPGQELAKIICAQLLG
AGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNK
VRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRKFINYFGFHEELQGIHKTPLFV
AAVCTDWFKNPSD-QPFQDVALFKAYMQYLSLKHK--GAAKPLQATVSSCGQLALTGLFS
SCFEFNSDNLAEAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSS
DRQEDQDLGLYYLRQINSPLKAMSIY-HTFLKYVSSHPSSKAAPTVVSHLLQLVDEKESL
ENMSENEDYMKLHPEALLWIE-CLRGLWQLSPESFSLFISENLLRICLNFAHESNTVAAC
SPVILQFLRGRTLDLKVLS------LQYFWDHPETLLLLKSIKISLNGNNW--VQRIDFS
LIEKSF--EKVQPPTIDQDYAIAFQPINEVQKNLSEKKHIIKKYEDMKHQIPLNISTGYW
KLSPKPYKIPKLEVQVTNTGPADQALLQVLMEVFSASQSIEFRLSDSSGFLESIRPALEL
SKASVTKCSMSRLE-LSREDQKLLLTLPTLQSLEVSETNQLPDQLFHNLHKFLGLKELCV
RLDSKPDVLSVLPGEFPNLHHMEKLSIR-TSTESDLSKLVKLIQNSPNLHVFHLKCNFLS
NCEPLMTVLASCKKLREIE-FSGRCFEAM--TFVNILPNFVFLKILNLRDQQFPDKETSE
KFAQALGSLRNLEKLFVPTGDGIHQVAKLIVRQCLQLPCLRVLVFAETLDDDSVLEIAKG
-ATRGGFQKLENLDLTLNHKITEEGYRNFFQVLDNLPNLKNLDISRHIPECIQIQAITVK
ALGQCVSRLPSLTRLGMLSWLLDEEDIKVINDVKERHPQSKRLTVHWRWVVPFSPVIQK-
--

--MATQQKASDERISQFDHD--LLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAAAGFYFTG-VKSGIQCFCCSLILFGAGLTRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLASFKNWPF
YVQGIPPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEITQYIQSYQ-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPRESA-VGVAALAKAGLFYTGIKDIFQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVIPDL-QSHGELCELL--ETTSESNPEDSIAVDPI----V-----
-----------------------------------PEMAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSFSSTRPDQGLASIICDQLLE
KEGSVTEMCMRNILQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRACLLIAVRTDK
ARDIRRYLETILEIKAFPFYNTVFILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFV
AAICAHWFQYPFD-PSFDDVAVFKSYMERLFLRNK--ATAELLKATVSSCGELALKGFFS
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLES
DRQEHQDLGLYHLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LLRGLWQICPQAYFSMVSEHLLVLALKIAYQSNTVAVC
SPFVLQFLQGRTLTLGALN------LQYFFDHPESLSLLRSIHFSIQGNKT--SPRAHFS
VLETCF--DKSQVPTIDQDYASAFEPMNEWERNLAEKEDDVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLKVNVNDIDAVDHEMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSV
DLEGKINVFSVIPEEFPNFHHMEKLLIQ-ISAEYDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTILASCKKLTEIK-FLDSFFQPV--PFVAILPNFISLKILNLEGQQFPDDETSE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKV
-AINGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTEVIKTHATTVK
SLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLNILQKWILPFSPIIQK-
--

--MATQEKAPEERISQFDYA--LLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYN---TFRSWTSQEMAEAGFYLTG-TKSGIQCFCCSLILFGTSLQNT
PMEHHKKFHPDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIAKYDVRVQKPENTLRRDDKARYQEEKA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFKNWPF
YAQGTSPRELSAAGFVFT--GKHDTVQCFSCG--GCLGNWEDDDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 301)

QSKKSLEEITQYIQSYK-GFVDVTGEHFL-NSWVKRD-LSVASVCCNGSNSSSFVNEELL

PF00653 // ENSGT00500000044782_2_Domain_2 (301, 367)

LQSFKSWHPSYP-VGAAALAKAGFFYTGKSDIVQCYSCGGYLHDWKEGDDPLEEHAKFFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QSVKSSA-EAIPDL-QSHDELSELT--ETTNEGNLEESTAVSSI----VP----
------------------------------------EVAQG-EAQWFQEAES-LSEHLRK
V-YTSAPFCHM-SLL--EISSCLATDQWLDCDLSFALKHITNPVQEPVVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 691)

V
MCVEGEAGSGKTILLKKIAHLWASGRCPLLNRFRLVFCLSLGSTRPEQGLASVIRDQLLE
TKLSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIARMIQKKHLSRTCLVITVRTNR
AKNIRRYLDTIIEIKAFPFYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLFV
AAVRASWLQNRFH-RSFDSVAVFESYMECLFLKHK--TEADLLKATVSSCGDLALKGFFS
SCFEFSDEDLIEAGIGEEEDLAMYLMSKFTAQRLRPVYQFLNPAFQEFLAGMRLTELLDS
DRQEDQDLGLHYLKRINSTLMVIYPY-ANFLNCVSRHPSTKAGPKIVSHLLLLVDNKETL
ENISENDDYLKHHPEISEVMQ-FFRLIWQLSPQNYLSLASKHLLALAIRIAYQSNTVAAC
SPFILQFLRGRTLCLDVLK------LQYFFDHPESLLLLRSIQVSINGNRLFK---T-DT
PLERIF--DKSQAPTIEQDYASAFELESEWKQSLDEKHEIIQNFQNMRLNAPPAINTGYW
NLPSKQYKIPLLEVHVTNTHAVDQEMLRFLTEVFSAAQHIELHLNHSRGFIENIRPALEQ
FRASFTKCCISQCE-LSAIEQELLLTLTSLESLEVSETTHPQDQLFLSLDKFLCLKELSV
NL--QQDVFSAISEEFLNLHHMEKLLIQ-ISSKCSPSKLVRLVQNSPNLQVFHLECNSFS
DFESLVTALASRKKLEEIK-FSGQFFQAN--PFVIVLPNFTSLKILKLGIQYIPDKETAE
KFAYALGSLNNLEELILPTGDGIHQMAKLIIQQCQHLQCLQVLQFFKTLDDDSVVEIAKV
-AINGGFQKLKHLDFSMNHKITEEGYRNFFQTLDNLPSLQELTISRHFKECIKVQAATVK
SLSQCVLRLPSLLRLNMLSWLLDAEDITLLTATIKKHPQSKHFILSWKWILPFSPIIQEP
IS

--MATQQEASDERISQFDYD--FLPELSAILGIDAVQLAKEMEEDQQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGTSLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLGSRLRG-GKMRYQQEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRNWPF
YAQGISPPVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESE-VGAAALAKAGLFYTGIKDIVQCFSCGRCLEKWQEGDDPLEDHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-GSDS---------RPSE--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLTTDHLLGCDLSIASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVNIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VTAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEHLLVLALNIAYQSNTVAAC
SPLVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSIKGNKT--SPRFDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRRAPPDLSTGYW
KLSPKQYKIPCLEVHVNGIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLELSGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTALASCKKLTEIK-FSDSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFQALDNMPNLQELNISRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGLDAVQFAKEMEEEQQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRNWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKAIVQCFFCGGCLEKWQEGDDPLENHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-RSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
V-YTSASFRHT-SLL--DLSSDLATDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEVGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVNIICDQLLE
KEVSVTEMCMRNILQRLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAYWFQYPFD-PSFCDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRLEHQDLGLYYLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEIALKMP-LIRVLWQICPQAYFSMVSEHLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKILN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRFDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAMRRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNDIDAVDQEMLEILMTVFSASQRIELHLNHCGGFIEGIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLQGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTVLASCKKLTEIK-FSDSFFEAV--PFVAILPNFTSLKILNLAGQHFPDEETSE
KFGMFTK-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-CQF-LHNMKCSA-EVIPDL-QSHGELSDLT--ETTSESNLEESAV-SSAVP--------
------------------------------------EVAHG-EAQWLQEAKS-LSERLRK
A-YTSAPFCHM-SLL--EVSSCLATDQLLNCDLSLASKHITNTVQEPVVLPEVFANLN

PF05729 // ENSGT00500000044782_2_Domain_3 (539, 693)

SV
MCVEGEAGSGKTVLLKTVALLWASGCCPLLHRFQLVFYVSLGSARLDRGLANVICDQLLE
TEGSVTETGLWNIIQQLKNQVLFLLDDYKEMCSVPQSIERMIQRNHLSRTCLLIAVHTNR
AKDIRRHLDTILEIKAFPFCNTLYILRKLFPD

ENSGT00500000044782_2_Linker_3_4 (693, 1248)

DLTRLRKFMVDFRINETWLGIQKTPFFV
AAVCANWLRYPFC-QSFDDVAVFKSYLECLFLRHK--TAADLLKATVSSCGELALKGFFS
SCFEFSDDDLLEVGIGEDEDLAMYLMSKFTAQRLRPVYQFLNASFQEFLAGMRLTELLDS
DRQEDQDSGLHYLKQINSAMMAIGPY-ANFLNYVSCHSSTKAGPTIVSQLLLLVDNQETL
ENISENDDYLKHHPEISEQMQ-CLRLLWQYSPENYLSLVSKHLLALAVKTAYRSNSVAAC
XXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX
XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXQDQLFLSLDKFLCLKELSV
NLDDKRDVFSVIPEEFLNLHHMEKLLIQ-ILAEYGPSKLVKLIQNSP

PF07723 // ENSGT00500000044782_2_Domain_4 (1248, 1273)

NLRVFHLQCNFFS
DLESLMTVLASCKKLEEIK-LTGPFFKAA--PFVIVLPNFISLKILNLEHQYIPDKETAE
KFAYTLGSLNNLEELILPTGDGIHQVAKLIIQQCQHLQCLRILSFFQTLDDDSVVEIAKV
-AINGGFQKLKNLNLSINHKITEEGYRNFFQTLDNMPNLQELTISRHFKECIKAQAITVK
SLSQCVLRLPRLTRLNMLSWLLDAEDITLLNAVIERHPLSKHFTLHWKWVLPFSPIIQK-
--

--MAEHGESSEDRISEIDYE--FLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 136)

RLKTFESYD---TFRSWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFGNSLRKL
PIERHKKLRPECEFL

ENSGT00500000044782_2_Linker_0_1 (136, 171)

QGKDVGNIGKYDIRVKSPEKMLRG-GKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRALSAAGFVFT--GKRDTVQCFSCG--GSLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQDYE-GFVHVTGEHFV-KSWVRRE-LPMVSAYCNDS---VFTNEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDMFKDWPQESP-VGFEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFP
ECVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPTL-QSQYALPEAT--ETTRESNHDDAAAVHSTVV--------
------------------------------------DLGRS-EAQWFQEARS-LSEQLRD
T-YTKTSFCHM-NLP--EVCSSLGTDHLLGCDVSIISKHVSQPVQGALTIPEVFSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICTQLLG
AGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLFRTCLLIAVHTNR
VRDIRPYLGTSLEIQEFPFYNTVFVLRKFFSHDIICVEKLIIYFSENKDLQGVYKTPLFV
AAVCNDWNQNASAQDDFQDVTLFHSYMQYLSLKYK--ATAESLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDVKLTTFLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSS
DRQEDQDLGLYYLRQIDSPLKAINSF-NIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESL
ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESFSSFVSEHLLRLALIFAYESNTVAEC
SPFILQFLRGRTLALRVLN------LEYFWDHPESLLLLRSLKVSINGNKM--SSYVDYS
F-KTYF--ENLQPPAINEEYTSAFEHVSEWRRNFAQDEEIIKNYENIWPRALPDISEGYW
NLSPKPCKIPKLEVQVNNMGPADQALLQVLMEVFSASQSIEFHLFNSSGFLESIRPALEL
SKASVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCV
RLDGKPDVLSVLPEEFLNLHHMEKLSIR-TSTESDLSKLVKFIQNFPNLHVFHLKCDFLS
NCESLMTALASCKKLREIE-FSGQCFEAM--TFVNILPNFVSLKILSLKGQQFADKETSE
KFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHDILDDESVIEIARA
-ATSGSFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQMLNICRNIPGRIQVQATTVK
ALGHCVSRLPSLTRLGMLSWLLDEEDMKVINDVKERHPQSKRLTIFWKWIVPFSPVVLE-
--

--MATHGEASEERISEIDYE--FLPELSALLGVDAAQLAKSQEEEDHQERMKMKKGFHSH
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRSWTPQDMAAAGFYFTG-VKLGVQCFCCSLILFGTSLRKT
PIESHRRLRPGCEF

ENSGT00500000044782_2_Linker_0_1 (135, 179)

LLGKDVGNIGKYDIRMKSPEK-LRG-GKARYQEEEARLESFENW

PF00653 // ENSGT00500000044782_2_Domain_1 (179, 241)

PF
YAHGTSPR-------------KRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QRKKSSKEIAQYIQSYE-GFVHVMGEHFV-NCWVRRE-LPMASAYCNDS---IFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPLESP-VAVEALVRAGLFYTGKNDIVRCFSCGGCMWKWEEGDDPLEDHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNLKSSA-EAIPDL-QSHCALPEAM--NTTGESNHEDPVTVHSTVA--------
------------------------------------DLAQS-AAQWFQEAKS-LSEQLRG
A-YTKATFRHI-NLP--EVCSGLGTDHLLGCDLSMVSKHISRPVQEALMLPEVLSNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKKTAFLWASGCCPLLNRFQLVFYISLGSTRPDQGLADIICAQLLE
AGGCISEVGLSSIIQQLKHQVLFLLDDYHGMDSLPQAIKTLITRNYLTRTCLLITVHTNR
ARDIRPYLDTILEIKEFPLYNTISVLRKLFSHDLARVEEFIVYFGNNEDLQGINKTPLFM
AAVCTDWFQNPSD-QSFHDVAAFKSYMKYLSLKHK--ATPEPLKATVSSCGQLALRGLFS
SCFEFSNDDLTEAGVDEDEDLTTCLMSKFSAQRLRPVYRFLSPLFQEFLAAMRLTELLDS
ERQEDQDLGLGYLRQINSPLKAINSY-NIFLKYVCSHPLSKAGPKIVSHLLQLVHDKESL
ENMSENEDYMKLHPETSLWMQ-FVRGLWQVSPEAFSSFVSEHLLSIALNFAYESKAVAAC
SPFILQFLRGRTLALKVLN------FQYFGDHPESLSLLRGVKFSINGNKT--TSHIDYA
-FKTYF--EKMQPPTIDQDYSSAFEHISEWKKTSIAYEEAIKNYINIRPRAPPDISAGYW
KLSPKPYKIPRLEVRVASMGPADPALLRVLMEVFSASQNIELHLNHSSGFLESIRPALEL
NKTSVTKCSMCRLE-LSAAEQELLLGLPVLQSLEVSGTNQLPDQLFANLDKFPSLKELSV
GLDGIPDVLSVIPGDFANLHHMEKLSIQ-TSTESDLSKLVELIHNSPNLQVFQLECDFFS
NCEPLMTVLASCKKLREIE-FSGRCFEAM--PFVTILPNFVSLKILNLKRQQFPDKETSE
NFAQALGSLRNLEELLLPSGDGIHHVAKLIVRQCLQLRCLRVLAFKETLDDDSVMEIAKG
-ATSGGFQKLETLDLSMNHKITEEGYRHFFQALDNLPSLQVLNICRRIPDSIQVQATTVK
ALSQCVSRLPSLTRLEMLSWLLDEEDMKVINAVKERHPQSERLTVLWKCIVPFSPVIQK-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------YGNDS---VFANEDL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKNWPHDSP-AGVAALVRAGLFYTGKKDIVQCFSCGGCMEKWEEGDNPLEDHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QSMKSST-KEIPDL-QSHRELPEAT--ETTCESNHEDSVAVHSTTA--------
------------------------------------EAAQS-EAPWFQEAKS-LSEQLRA
A-YISASFRQL-SLP--DICPSLRTDHLLGCDLSIVSKHISRPVQEVLVLPEILANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 691)

V
MCVEGEAGSGKTAFLKKIAFLWASGCCPLLNRFQLVFYLSLTSTRPDQSLANIICDQLLK
AEGSVSEVCLSSSIQQLKHQVLFLLDDFHEMSSVPQVIEKLIERNYLSQTCLLIAVHTNR
VRGIRPYLDTILEIKEFPFYNTIDVLRSFFSYNTTCFRKFLIYFIHNKDLMGIHKTPLSV
AAVCAHWLQNPSD-PSLDDVTVFKSYMECLSLKHK--TKVELLKATVSSCGQLALRGLFS
SRFEFSSDDLREAGVDDDEDLTTFLMSKFTAQRLRPVYRFLSPEFQEFLAGKRLVELLSS
DRQEDQDLGLCYLKQISSEKKAVISY-NNFLKYVSSHPSAKAGPKIVSHLLQLVDNKESL
ENACDNEDSVKLHPETSLSME-IIRGLWQFFPEKFCSLVSEHLLAIALDFACQSNTVAAC
SPVISQFLQGRTLALSVLN------LQYFGDHPESLLLLRSIKVSIKGDKM--ALRTDSS
LLGKCW--EKLQPPTVDQDYASAFEDINERNKILAENEKNIKTYASIKREPPPCISGGYW
QLSPKQYKIPCLEVHVDNMGPADQEMLRVLMEVFSASQHIELHLYHSTGFIESIRPALEL
NKASVTKCSLCQLE-LSAAEQELLLTLPALRSLEVSVTNQLQDLIFPNLDKFPCLTELSV
ILHGKLDVLSVIPEDLPDFHHMEKLSIQ-TSIESDPSKLVKLIQNSPNLQAFCLKCDFFS
GSESLMTVLASCKKLKEIG-FSGRCFEAV--SFVTILPNFISLKILDLESQQFPDKETSE
KFAHTLGSLRNLEELLLPHGDGIHHVAKLIVRQCLQLQSLRVLSFRQTLDDDSVMEIAKV
-AVSGGFQKLENLDLSTNHRITEEGYRNFLQSLDNLPNLQELNISRLPPECIEVQATTVK
ALTQCVLRLPGLTSLGILSWLLDEEDRKLLNAVKDRHPQSKCFIIFWKWVLPFSPVIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDEQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRHWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITAEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEHLRA
A-YTSASFRHM-SLL--DISSDLGTDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDKKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEYLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRFDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNNIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIRNSPNLHVFHLKCNSFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------YCYDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHKSP-GAVEAMVRAGLFYTGKSDTVRCFSCGGCMWKWEEGDDPLEDHAKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVTPAL-QSHCALPETM--DTTGGSNHEDPVTVLSTV---------
-------------ADVAPSEAQGCECPSSGACVLSTDLAQS-EAQWLQEAKS-LSEQLRA
A-YTKATFRHM-NLP--EVCSSLGTDHLLGCDLSIVSKHISRPVQEALTLPEVFTNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKKTAFLWASGCCPVLNRFQLVFYISLSSSRPDQGLASIISAQLLE
AGGSISEVCLSSSIQHLKHQVLFLLDDYSGMDSLPQAIETLITKNYLSQTCLLIAVHTNR
ARAIRPYLDTILEIKEFPFYNTISVLRKVFSHDIICVRRFINYFGKNEDLQGIHKTPLLV
AAVCTDWFQNPSD-QSFHDVAVFKSYMKYLFLKHE--ATPGPLKATMSSCGQLALRGLFS
SCFEFSSEDLTEAGVDEDEDLTTCLMSKFTAQRLRPVYRFLSPLFQEFLAAMRLTELLGS
EREEDQDLGFEYLRQVNSPLKALSVY-NNFLKYVSSHPSSKAGPKIVSHLLQLVSDKESL
ENMSENEDYGKIHPETSQRMH-LIRGLWQLSPEAFSLFISENLLNIALKFAYESNAVSVC
SPFILQFLRGRTLALNVLN------LQYFGDHPESLLLLKSIEVSISGNNS--VQRIDFS
SMEKCF--EKVQPPTIDEDYTSAFQSINECEKNLAEKEDIIKNYVDIKHQAPPNISAGYW
KLSPKQYKIPRLEVGVTNMGPADQALLRVLMEVFSASQDIELHLMHSSGFLESIRPALEL
NKTSVTKCSLCRLR-LSAEEQQLLLALPALRSLEVSGTNQLPDQLFPNLDKFPSLRELSV
RLDGSPDVLSVIPGDLPNLHHMEKLSIQ-TSTESDLSKLVKLIQNSPNLHVFHLKCDFFS
NCESLMTVLASCKKLREIE-FSGRCFETR--PFVTILPNFVSLKILNLKRQQIPDKETSE
KFAQALGSLRNLEELLLPTGDGIQQVAKLIVQQCLQLPCLRVLAFVETLDDDSVMEIAKG
-ATSGGFQKLENLDISMNHKITEEGYRSFFQALDNLPNLQNLDVSRHLPECIQAQATTVK
ALSQCVSRLPSLTRLGILSWLLDEEDVKVVNAVKERHPQSKCLIIHWRWVVPFSPVLQK-
--

--MAAKGEAFEERISEFDDE--LASEFSALLGVDALQVRKRQDEEDHQERMKMKKGFNSH
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYN---TFRSWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFCTRLRKT
PIESHRKFRPGCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDISMKSPEK-LRG-GKARYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRRE-LPMVSAYCNDS---IFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHDSP-GAVEALVRAGLFYTGKNDIVRCFSCGGCMSKWEEGDDPLEDHTKFFP
NCVF-LQNLKSSA-EEIPAF-QSHYTLPEVT--DTTGESNHEDPVAVHSMVA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------DQLFANLDKFLSLKELSI
SVNGIPDVLLVIPGDFSNLHHMEKLSIQ-TSTESDLSKLVKLIQNSPNLHVFHLECDFFS
NCESLMTVLASCKKLREIE-FSGRCFEAM--PFVTTLPNFVSLKILKLGRQQFPDKETSE
KFAQALGSLRNLEELLLPSGDGIHHVAKLIVRQCLQLRCLRVLAFKETLDDDSVMEIAKG
-ATSGGFQKLENLDLSMNHKITEEGYRHFFQALDNLPNLQVLNISRHLPESIQVQATTVK
ALSQCVSRLPSLIRLHMLSWLLDEEDMKVINAVKERHPQSKCLIVHWQWVVPFSPVIQK-
--

MKMTTQ-EEAEEKISQFDYA--LASELSSLLGIDAMAFMKEKEEEEHRDRAKMKKGFNSR
MRSEAN

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLRTFVTYK---TYSSWTPQDMAAAGFYFTG-VKSGVQCFCCSLILFGTSTRRV
PVESHKEFRPGCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGRDVGNIGKYDVRVRTPEKEPSG-VRARYGQEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFRDWPF
YVQAVSPKVLAAAGFIFT--GKRDTVQCFSCG--GCLGNWEEGDDPWQEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYQ-GFVEVTGEHFV-NSWVKRE-LPMASAYDNDS---VFANEDL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
QDTFRNWPREA--SAVAALVKAGLFYRGVEDQVQCFSCGGCMKNWQEGDDPLADHTKYFP
SCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVIPDL-QDCGKLPEIM--ETTSESKLEE----------P------
----------------------------TAVSSLTPDAAPG-EAPWCREAKS-LSELLRS
A-YTSARFRHL-SLL--ESPSGLPSDHLLGCDLALTAKRASSPVQEPLTLPEVLANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MSVEGEAGSGKTVLLKKIAFLWASGCCPLLHRFQLVFYLSLSSISPDEGLAHIICDQLLA
AGGTVSEMSLRSMTRQLGNRVLFLLDDYRARGSVPRVMETLIHRSHLSRTCRLIAVRTNR
GRDIRRHVDTVLEIGVFPFYNTFSILRRLFPHDQPRLRKLLVHFGKNPQLQGIHKTPLFV
AATCAYWFQYPSA-QSFDHLAVFKAYMECLFLKHK--TSAELFRGTVASCGELALKGFFS
SRFEFSGDELAEAGVDEDEDLTMCLMSRFTAQRLRPVYQFLSPAFQEFLAGKRLSELLDS
DKQEDQDLGLYYLKQINSPLLAGSSY-RNFLKHVSSYSSTKVGPKVVSHLLHLADSRESL
ENPPGSGGCPQREEEMPPYAQ-AFRLLWQMWPEHCFPLLAEHLLDFSLRVAYESNTVATC
APFISKFLQGRSLPWGLLS------SQYFFDHPESLQVLRSVTVSLTGSNPS-PRLLHSE
ILGGCF--DRSQTPTVDQDYASAFESLNEWEQDMVEKEENIKRYHKLQAQRTPDLSRGYW
QLRPPPHKLPLLQVRVTHQSAAGPELLAALAAVFAASQRIELHVEESAGFLESVRPALQP
SRAAVAKCALR-GVPLSAAEQELLLALPALEALDVSGAGQVPDQIFPNLDKFPCLRELSV
NLDSGPDVFSLLPEEFPNLHHMEKLLIQ-ILDGCDASKLVKLIQNSPDLRVFRLNCCAFS
DFESLMTALASCKKLNEIT-FCGPFFDAI--PFVTILPSFTFLKILNLKDQQFPK-ETAE
KFAGALGCLTDLEELVLPTGDEIYQVAKRIIQQCQRLLRLRVLSFLQILSDDSLAEIAKV
-SISGGFQKLEDLNLSINHKITQDGYRNFFQALDSLPNLRELNISRHFTECITAQASTVK
ALGQCVSRLPSLVLLTMLGWLLDAEDVTLLDAVKERHPQSKRLQIFWKWRLPFSPIIQK-
--

--MSTKGEAAEERISEFGDD--LASEISVRLGIDTFQLIKKYEEEDHKDRMRMQKGFNAQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRSWTPQEMAAAGFYFTG-VKSGVQCFCCSLILFCTSLRRL
PIESHKKFHPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDVRVRSPEKMLRG-GKARFLEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFQNWPF
YAHGTSPRALSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKPTEKIAEYIQSYE-GFVHVTAENFV-DSWVKRE-LPMTAAYGKDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKNWPHDSP-AGVAALVRAGLFYTGKRDIVQCFSCGGHMEKWEEGDDPLEDHTKYFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EEIPDL-GSHRELPEAM--ETTNESNHEDSVAVHSTMA--------
------------------------------------EAAQS-EAPWFQEAKS-LSEQLRA
A-YISASFRRL-SLP--DICSSLHTDHLLGCDLSIVSKHISRPVQKALVLPEILANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTAFLKKIAFLWASGCCPLLNRFQLVFYLSLTSTRPDQSLANIICDQLLK
AEGSVSEVCLSSSIQQLKHQVLFLLDDFHEMSSVPQVIEKLIERNCLSQTCLLIAVHKNR
SRDICPYLDTILEIKEFPFYNTVYVLRSFFSHNIIHLQEFMVYFGMNKGLQRIHKTPLFV
AAVCAHWLQNPSD-PSLESVTVFRSYMECLSLKHK--TRSELLKATVSSCGQLALRGLFS
SCFEFISDDVREAGVDDDEDLTTFLMSKFTAQRLRPVYRFLSPEFQEFLAGMRLVELLGS
DRQEDQDMGFYYLKQINSPMKAISSY-SNFLKYVSSHPSAKAGPKIVSHLLQLVDNKEPF
VNISENEDSLMLHPETSLQTK-IIRGLCQVSPEAFSSVISESLLTIALKVAYQSNTVAAC
SPVVSQFLQGRTLALSVLN------LQYFGDHPESLLVLRSIKISINGNKT--APRVSYS
DMEKCF--ETLQPPTIDQDYASAFEHMNEWEENVAKNEENIKNFKNMQCKPPPRISGGYW
QLSPKQHKIPCLEVHVDNMGPADQEMLRVLMEVFSASQHIELHLYHSTGFIESIRPALEL
NKASVTKCSMCQLE-LSEAEQELLLTLPALRSLEVSRTNQFQDLILPNLDKFPCLKELSV
TLDDKPDVLSVIPEDFPNLHHMEKLSIQ-TSTESDPSKLVKVIQNSPDLQVFHLKCDSFS
DFESLMTVLVSCKKLKEIG-FSGGYFDAL--PFVTILPNFISLKTLNLEYQHFSNKEASE
KFAHTLGSLRNLEELLLPHGDGIHHVAKLIVRQCLQLQSLRVLSFRQTLDDDSVMEIAKV
-AVSGGFQKLKNLDLSLCNKITEEGYRNFFEVLDNLPNLQELNISRHLPQCIKVQATTVK
ALSQCVSRLPSLTRLTMLSWLLVEEDMKLLNAVKERHPQSKCFTIIWKWILPPSLVIQK-
--

--MATHGEASEERVSEFDYD--FLPELSALLGMDAGQLVKSQEEENHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFSSWTPQEMAAAGFYLTG-VKLGVQCFCCSLILFGTNLRKI
PIERHRELRPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDVRVKSPEK-LRG-DKARNQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRR-ELPVVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHNSP-GAVEALVRAGLFYTGIRDIVQCFSCDGCMENWKEGDDPLEDHTKFYP
NCVF-LQYLKSSA-EVTPAL-QSHCEILKAM--DTTGGSNHEDPVTVLSTV---------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------ADQLFPNLDKFPSLRELSV
RLDGSPDVLSVIPGDLPNFHHMEKLSIQ-TSTESDLSKLVKLIQNSPNLHVFHLKCDFFS
DFESLMTVLASCKELREME-FSGRCFETR--PFVTILPNFVSLKILNLECQQFPDKETSE
KFAQALGSLRNLEELLLPTGDGIQQVAKLIVQQCLQLPCLRVLVFHHILDDDSVMEIAKG
-ATSGGFQKLETLDLSVNHKITEEGYRNFFQALDNLPNLQVLNICRSLPERIQVQATTVK
ALSQCVSRLPSLTRLEILSWLLDEEDMKVINAVKERHPQSKRLTVLWKWIVPFSPVIQK-
--

-MTTQE-EASEEKISQFDYD--LAPEMSSLLGIDVIPFIKEQEEQEQRDRAKMKKGFNCQ
MRSEAR

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYK---PYSSWTPQDMAAAGFYFTG-VKSGVQCFCCSLILFGTSLGKF
PVESHKKFRPGCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGRDVGNISKYDVRVKTSGKEPAA-IGARSLEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLASFRDWPL
YVQGVAPRALAASGFVFT--GDRDTVQCFSCG--GCLGNWEEGDDPWQEHAKWFPKCEFL
QSKKSSEEISQYIQSYQ-GFVDVTGEHFV-NSWVRRE-LPAASAYDSDS---IFTNEELR
WDTFKNWPRAS--LPTVE------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------AL-------------------
------------------------------------------------------------
------------------------------------------------------------
----------VK------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------AGLSYRDQIFPNLDKLPCLRELFV
NLDSRLDVFSLLPEEFANLHHMEKLLIQ-ISAGCDASKLVKSIQNSPNLRIFHLKCYSFS
DFESLVTTLASCKKLEEIK-FSGPFFKAT--PFVTILPNFTFLKILNLEHQQFPDKETSE
KFACTLGSLTHLEELVLPTGDEIYHVANQIIQQCQQLLCLRVLSFFQILNDDSVVEIAKV
-AISGGFQKLEDLNLSINHRITQDGYRNFFQALDNLPSLRELNVSRNFTECIVAQARTVK
ALGQCLCRLPSLLTLNMFGWLLDAEDITLLDAVKERCPQSKRLHIFWKWRLPFSPIIQK-
--

--MAAQGEAFEEIICEFDDD--LVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFETYD---TFRSWTPQEMAAAGFYYTG-MKLGVQCFCCSLILFSTRLRKL
PIENHKKLRPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDIRVKSPEKMLRG-XKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RXESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GSLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSPEEITQYVQSYE-GFLHVTGEHFV-NSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDTFKDWPHESP-GAVEALVKAGLFYTGKRDIVQCFSCGGCMEKWAEGDDPIEDHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPAL-QSQFVLPEAM--ETTSENNHDDPAAVHSTVL--------
------------------------------------DLGQS-EAQWFQEARS-LSEQLRD
T-YTKATFRHM-NLA--EVCSILGTDHLLGCDVSIISKHISQPVQGALTIPEVFSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSTTPDQGLANIICAQLLG
AGGCISEACLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNR
VRGIRPYLDTSLEIKEFPFYNTVSVLRKLFSHDIMRVRKFINYFGFHEDLQGIHKTPLFV
AAVCTDWFGNLSD-QPFQDVALFKAYMQYLSLKHK--AAAKPLQATVTSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEELTTYLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSS
DRQRDQDLGLYYLRQINSPLKAMSIY-HTFLKYVSSHPSSKAGPAVVSHLLQLVDENVSL
DNMSENEDYMKLHPEALLWIQ-CLRGLWQLSPESFSLFISENLLRIALNFAHESNTVAAC
SPVILQFLRGRTLDLKVLS------LQYFWDHPETLLLLKSIKVSLNGNIC--VQRINFS
LMEKSF--EKVQPPTIDQDYTIAFQPINEVQKNLSEKKHIIKKYEDMKHQIPLNISTGYW
KLSPKPYKIPRLEVGVANTGPADQALLQVLMEVFSASQSIEFCLFDSSGFLESIRPALEL
SKASVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCV
RLDGKPDVLSVLPGEFPNLHHMEKLSIR-TSTESDLSKLVKLIQNSPNLRVFHLKCNFLS
NCESLMTALASCKKLREIE-FSGQCFEAM--PFVNILPNFVFLKILNLRDQQFPDKEISE
KFAQALGSLTNLEELHVPTGDGIHQVAKLIVRQCLQLPCLRVLVFAETLDDNSVLEIAKG
-ATRGGFQKLENLDLTLNHKITEEGYRHFFQVLDNLPNLKNLDISRHIPECIQIQATTVK
ALGQCVSRLPSLTRLRMLSWLLDEEDIKVINDVKERHPQSKRLTIHWRWVVPFSPVIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDQQKVQATMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRNWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITAEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELL--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQMCPQAYFSMVSEHLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRCDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNDIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--------------------------------------------------MKMKKGFNPQ
MRNEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRTWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFCTRLRNL
PIESHKKLHPDCAF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDIRVRSPEK-LRG-GKARYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCA--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
RSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHTSP-VAVEALARAGLFYTGKKDTVRCFSCEGCMCNWEEGDNPLEDHTKFFP
NCVF-LQNLKSSA-EMSPAL-QSHCALPEAM--DSTRESNHGDPAAVHSTMA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------VKLIQNSPNLHVFRLKDTVFS
DFESLVTALASCKKLREIE-FSRQCFETM--PFVNILPKFVSLKILDLKCQQFPDKETSE
KFAQALGSLRNLEELLLPTGDGIQQVARLIVQQCLQLQHLRVLYFVETLDDDSVMEIAKG
-ATSGGLQKLENLDLSMNHKITEEGYRNFFQVLDNMPNLQNLDISRHLPERIQVQATTVK
ALSQCVSRLPSLTRLGMLSWLLDEEDLRVINAVKERHPQSKYLIVHWRWVVPFSPVIQK-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-CQF-LRNMKSSA-EVIPNI-QSSGELS-GFTEST-RESHQEDS-IVHSAVL--------
-----------------------------------PETVQGE-ALWFQEAKR-LSEQLRE
A-YIKASFRR-LSLLD--VSPGVPSDLLLGCDLSLASKQVGSPGQEPVVLSEVLANLN

PF05729 // ENSGT00500000044782_2_Domain_3 (539, 693)

SV
MCVEGEVGSGKTVFLKKIALLWASGCCPLLSRFQLVFYLSLGTARLEQGLTSMLGDQLLE
AGASVSETCLGHIIQKLKNQVLFLLDDYKEMSTMPYVIKKLIQKNHLSRSCLLIAACTHR
ARDIRRYLDTILEIGVFPFYHTIFILKRVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXXXXX-XXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXSTFTAQRPKPVYHFLTRAFQEFLAGMRSTALLGS
ARQAEQELGLYYLKQINSPIMTLEAY-NNFLKYVCYHCSSKAGPIVVSHLLHLLE-KESW
ETLSENDDYLKHHPEMSEKMQ-FIRKLWQFFPQIYFSAVSEHVLTLAIEVAYQSGTVVTC
SPLLQQFLQGQTLPLVLLQ------SQYFSDHPESLSLLKSVQVFLSGKHR--LRKPDLS
QLEACF--DKSQAPSIEQDCVPAFETVKEWEQNLAESEADMNRYLNSQRVTLPAICSGYW
QLSPKPHKIPLLEVHVSDVEAMDAEILSNLMTIFSAC-HIELHLTYSGGFIESIRPALEQ
YQALFTKCTIVNSE-LSTVEQELLLTLHSLESLEVSKITQGHEKLFANLDKFQCLKE-SV
NLSDKEDVL-VIPENFLNHSHMEKLLIN-TLAEHSTSKLXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXHALGFLSDLEELLLPYGKGIHLVAKPIIQQCQHLQHLRVFSLYQNLNDDSLMEIAKV
-AINGGFQKLEKLDLSMNDEVTEEGYRNFFQALDNLPNLRELAISRHFKNCIKAQATTAK
SLSQCMSCLQSLTHLTMLSWLLDAEDVALLNAMKERHPQLKYLTLNWNWLLPFSPTIKE-
--

--MTTQ-EEEEEEVSQVDYE--LATEMTLFLGIDAMVYMKEQEEEEHRERVKMKKGFNCR
MRSEAS

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLRTFVTYQ---VYSSWTPQDMAAAGFYFTG-VKTAVQCFCCSLILFGTSLKKF
PIQSHRELRPGCQF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGRDVGNIGKYEVRVKTPGKKRSG-DTAGYGEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLKSFGDWPF
YVQAVSPQLLAASGFFFT--GKRDTVQCFSCG--GCLGDWEEGDDPWQEHAKWFPKCEY

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
QSKKSSEEIADYIQSYQ-GFVDVTGEHFM-NSWVKRE-LPMASAYDNNS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
RETFKNWPHREFLQAVDALVRAGLFYTGVEDEVQCFSCGGCMKNWQEGDDPLADHTKYFP
SCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EAIPDL-QGCGELSEIM--VCCVSRADASMRPLCVRPNTHTP--AG
DLVP--ALL-----------SSQVSINTQGRTMFRSSVVLG-EALWFQEAKS-LSEKLRA
T-YISAHFRRL-SLL--KSPWDLPSDRLLGCDLALTAKRVSSPVQEPQTLPEVLANLHS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MSVEGVAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSVSPDQGLAHVICDQLLA
T-GAVSEMGLKNITRQLGHQVLFLLDDYKARGSVPQVMETLIQRSHLSRTCRLIAVRTNK
GRHIRRHLHTILEVREFPFYNTISILRQLFPQDQLLLRRFMAHFGKNPHMQGIHKTPLFV
AAVCAFSQPFNLF-QSFDHMAIFKAYMECLFLKHK--TETELFRRTVSSCGELALKGFLS
FCFEFSVDDLTEAGVDEDEDLTMYLLSRFTAQRLRPVYKFLNPAFQEFLAGKRLSELLDS
DRQEDQDLGLYYLKQINSPLMAV-SY-DNFLKYVASYSSTKVGPHMVSHLLHLVDSKESL
ENPPGNGDRLQFKEEMTLDEQ-LIRAVWQLSPEHCFALLSERLWDFAVTIAYESNTVATC
APLISKFLQGRSLTLKALS------SPYFFDHPESLCVLKSVTLLLTGNEPR-LGLSESE
ILEGHF--DRSQMPTIDRDYASAFENSKEWERDLAEKEKNIRRFQKIRIQQLPHLSGGYW
QLQPQQPKLPLLQVHVTGHSAAGPEMLALLAAAFSASQRVELHLEASAGFLESIRPALEP
CKAAVTKCALG-SVPLSAAEQQLLLALPALESLEVSGSGQVPDQIFSNLDKFPSLRELSV
NLYGKHDVFSLLPEEFSN-HHMEKLLIQ-ISTGRGASKLVKLIENSPDLRIFHLNCNSLP
DLESLMTTLASCKKLNEII-FSGHFFDAI--PFVSILPNFTFLKILNLSEQQFPDTETAE
KFADALGSLTNLEELVLPTGDKIYQVVKQIIQQCQRLLCLRVLSFLNILNDDSVVELAKV
-SISGGFQKLEDLNLSVNHKITQDGYRNFFQALDNLPNLRELAISRHFSECLTAQPSTIK
ALSQCVSRLPCLLYLHMLGWLLDAEDVALLDAVKERHPQASRLHILWKWRLPFSPIIQN-
--

--MATQQKASDERISQFDHN--LLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAASGFYFTG-VKSGIQCFCCSLILFGAGLTRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLASFRNWPF
YVQGISPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
RSKKSSEEITQYIQSYK-GFVDITGEHFV-NSWVHRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPRESA-VGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRWFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVTPDL-QSRGEPCELL--ETTSESNLEDSIAVDHI----V-----
-----------------------------------PEMAQG-EARWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLE
KEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFV
AAICAHWFQYPFD-PSFDDVAVFKSYMERLSLRNK--ATAEILKATVSSCGELALKGFFS
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYHLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLQMQ-LLRGLWQICPQAYFSMVSEHLLVLALKIAYQSNTVAAC
SPFVLQFLQGRTLTLGVLN------LQYFFDHPESLSLLRSIHFSIRGNKT--SPRAHFS
VLETCF--DKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSV
DLEGNINVFSVIPEEFPNFHHMEKLLIQ-ISAEYDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTMLVSCKKLTEIK-FLDSFFQAV--PFVASLPNFISLKILNLEGQQFPDEETSE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKV
-AISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLKELDISRHFTECIKAQATTVK
SLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDEQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 255)

RLGSFRHWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCE----------------------------
-------EIAQYIQ

ENSGT00500000044782_2_Linker_1_2 (255, 320)

SYK-GFVDITAEHFV-NSWSRER-LPMGISKP--Q---TFSKGFYC
NDSIFDWPWESA-VGAAAP

PF00653 // ENSGT00500000044782_2_Domain_2 (320, 367)

AKQLSFYTSIKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 670)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVQ---
---------TILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPVFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDKKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEYLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRFDFS
VLEACL--DKSQAPTTDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNNIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKWIQNSPNLHVFHLKCNSFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MATEGKASEERISQFDYD--LLPELSTLLGIDAVQMAKEMEENEEKLRAKMQKGFNSQ
MRSEVK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFMTYE---SYSSWTPSEMAAAGFYFTG-VKSGIQCFCCSLILFGTSLRKF
PIEDHKKFRPHCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIAKYDVRVKNPRKKLRG-DKARYRNEET

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLESFKNWPF
YAHGISPHALSAAGFIFT--GERDTVQCFSCG--GCLGDWEEGDNPWKEHAKWFPKCEY

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
QSKKSSDEIAQYIESYK-GFVDVTGEHFV-NSWFKRE-LLMASAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKKWPHKSG-LKVAALARAGLFYTGVEDIVQCFSCGGCLHNWKEEDDPLEDHTKHFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSTA-EVIPDV-QSHGELPKVM--ETTTESNLEDSEAVNSI----G-----
-----------------------------------PEVAQD-KTQWFQEAKN-LSEKLRA
V-YTSASFRHM-SLL--ELSSKVATDHLLGCDLSIISKHISSTVQEPVVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTVLLKKIAFLWASGCCPLLNRFHLVFYLSLSSTRPDQGLASIICDQLLK
TEGTNTELCLMNIIRQLKNQVLFLLDDYKEMCSFPQVIEKLIKKNHSLRSCLLIAIHTNR
ARNIRRYLDTILEIQAFPFYNTIFLLRRLFPHNMTRLQKMMVHFGKNTNLQGIQKTPLFV
AAICTNWFQCPFD-QFFDDVAVFKSYMDYLFLKLK--STAERFKEIISSCSELALKGFFS
SCFEFTGNDLEEAGVDEDEDLTMCLMSKFTAQRLRPVYQFLSPTFQEFLAGIRLIELLDS
DRQDDQDLGLYYLKQIKSSMMAVFPY-ENFLKYVSSHPSSKAGPKLVSHLLHLVDNKESL
EDMSENDDYLKHRPDISMYME-FLRVIWQLTPNTYYSLVSKRLLDLALKIAYQSNTVAAC
SPFILQFLQGRTLTLNILN------LQYFFDHPESLLLLKSIVVSIQGKKR--KNFPNFS
SLEKCWEINKSQVPTIDQDYASTFKPMKEFEENLAEQEETINSFLDLQHRAPPDISAGYW
KLPSKQYKIPLLEVQVTSVDAVDQEMLRVLMEVFSASQHIELHLDHSNGFIESIRPALEL
NKTSVTKCSIHQCE-LCAPEQELLLTLPSLESLNISGTIQLQDQIFPNLDKFLCLKELSV
KLDDKPNTFSVIPEEFPNLHHMEKLLIH-ILGEDDSSKLVTLIQNSPNLRVFHLKCNFFS
KFESLMTALTSCKKLEEIW-FSESFFNVI--PFVTILPNFLSLKILNLSFQQFPDKETSE
KFAYTLGSLNHLEELILPTGDGIRQVAKLIIQQCQQLQCLRVLSFYQVLNDDSLMEIAKV
-AINGGFQKLENLNLSINHEITEEGYRNFFRALDNLPNLQELTISRHFTACITAQATTVK
ALSQCVLRLPSLTRLQMLSWLLDAEDLALLDAMKERHPKSKHLIISWKWILPFSPIIQK-
--

--MATQEKAPEERISQFDPA--VFPEMSAFLGVNALQYVKEIEEEEHRDREKMQKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYT---TFSSWMPQEMAEAGFYFTG-TKSGIQCFCCSLILFGTSLQSS
PMGHHKKFHPDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNILKYDIRVQNPEDTLRKDDKARYQDEKA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAQGTSPRELSAAGFVFT--GKRDTVQCFSCG--GCLGNWEDDDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSLEEITQYIQSYNLSFHFLQGEHFL-NSWVKRD-SSVASVCCNGS---IFVNEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LQSFKSWHPSSL-LGAAALAKAGFFYTGESDIVQCFSCGGYLHEWEEGDDPLEEHAKFFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QSVKSSA-EAIPDL-QSHDELSELT--ETTSESNLEESTAVSSI----VP--GK
DLEVAHGIIGIF-------------VYNCAPLLFSTEVAQG-EAQWFQEAEI-LSERLRK
V-YTSAPFCHV-SLL--ELSSCLATDQWLDCDLSFALKHITNPVQEPVVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 691)

V
MCVEGEAGSGKTIFLKKIALLWASGCCPLLHRFRLVFYLSLGSTRPEQGLASVIHDQLLE
TNVSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIARMIQKKHLSRTCLVITVHTNR
AKNIRRYLDTIIEIKAFPFYNTISILKKLFPGDLTHLRKLMVDLGMNQTWQGIQKTPLFV
AAVCASWLQNRFH-WSFHSVAVFKSYMECLFLKHK--TAADLLKATVSSCGELALKGFFS
SCFEFSDEDLIEAGIDEEEDLAMYLMNKFTAQRLRPVYQFLNPAFQEFLAGMRLTELLDS
DRQEDQDLGLHYLKQINSTLMAICPY-ANFLNCLSSHPSTKAGPKIVSHLLLLVDNKETL
ENISENEDYLKHHPEISELMQ-CFRLMWQFSPQTYLSVASKHLLALAVKVAYQSNTVAAC
SPFILQFLQGRTLCLDVLK------LQYFFDHPESLLLLRSIQVSIGRNTLFK---TDDM
PLERIL--DKSQAPTIDQDYASAFELESEWKQSLVEKQENIKRFHDTRLNAPPAISTGYW
KLPSKQYKIPLLEVHVTNTSAADQEMLKFLTEVFSAAQHIELHLNDSRGFIENILPALEQ
YRASFTKCCISQCE-LSAIEQELLLTLTSLESLQVSEKTHIQDQLFLSLDKFLCLKELSV
NL--QQDVFSVISEEFLNLHHMEKLLIQ-ISSKCSSSKLVRLVENSPNLQVFHLECNSFS
DFESLVTALASRKKLEEIK-LSGHCFNAN--PFVIVLPNFISLKILNLRFQYIPDKETAE
KFAYALGSLNNLEELILPTGDGIHQMAKLIVQQCQHLQCLQVLQFFKTLDDDSVVEIAKV
-AINGGFQKLKHLDFSMNHKITEEGYRNFFQTLDNLPNLQELTISRHFKECIKVQATTVK
SLSQCVLRLPSLMKLNMLSWLLDAEDITLLTTTIKKHPQSKHFTLFWKWILPFSPIIQET
IS

--MATQGKASDARISQYDPDPALHSEMSALLGVDIAQFQKDNEEEEERDRAKMQKGYNSR
MRSEAQ

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVAYK---PYSSWTPQEMAAAGFYFTG-VKSGVQCFCCSLILFATKLKQL
PVEDHKKLQPDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLESQPTR-DRGQYQEEQA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLDSFRNWPF
YAQGVSSHALSAAGFVFT--GNRDTVWCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSAEIAQYIQSYK-GFIDVTGEHFV-NSWVKRE-LPMASAYCNDS---VFAHEGL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKNWPHNSP-PGAAALAKAGLFYTGIQDIVQCFSCGGCLEKWKEGDDPLEDHTKFFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSFA-EAMPDL-QSHSKLCELP--EITSESNLEDSVAMSST----V-----
-----------------------------------PEMAQS-EAQWFPEAKS-LSERLRA
A-YTSSRFCHM-SLL--EISSDRPTAHLLGCDLSMASKNIGHPGQEPLVLPEVLANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVFLKKIAFLWASGCCPLLNRFQLVFYLSLSSTSPDQGLASLICDQLLE
KEGCVTETCMRNILQELKNQVLFLVDDYKEMCLVPQVIGKLIQKNFSSRTCLLIAVRTNR
TRDIRRYLNTVLEIQAFPFYNTVYILRKLFSDNVTRLRKLMVHFGKNEHLQGIQKTPLFV
AAVCAHWCQCPFD-LSFDDVAVFRLYIQCLFLRHQ--TTAELLRATVSSCGALALKGLFS
SCFEFSGDDLTNAGVDEDEELTTYLMSKFTAQRLRPVYRFLNPAFQEFLAGMRLIELLDS
DGQEDQDLGLSYLRRISSSIVAMSTY-GDFLNYVSRYPSAKSGPQIVSHLLRLAEKKEPL
ESMSEKVDPSKNHLGSSLNTE-AIRVLWEMAPQACFSMVSEEILALALKIAYRSNSTPAC
SPFILHFLQGRTLSLMTLK------SQYFFDHPESLLLLKSIKVLIRGNKVPH---MQRL
SEVAGW--DISPAPTVDQDYASAFVAMNEWEQNLAEKEAMHQRFYNIERRAPPDISTGYW
RLSPKPHKLPCLEVHVSHVNGVDQEMLRVLTEVFPASQHIELHLFSSGGFLESIRPALEL
CKASVTKCSIHTFEELSVSEHELLVTLSSLESLEISGRLQSQEQLFPNLDKFLCLRELSV
TLYDQVNDYLVLPEGFPNFHHMEKLLIN-IKSKYDSSKLVKLIQNSPNLHTFHLECNFLS
DFKSLMTVLASCKKLKELN-FSGHCFDAN--PFVAVLPNFISLKVLNLEYQYIPGEETAE
KFAHILGSLHNLEELSLPSGDGIRRVAKLIIQQCHQLPCLRVLLFIRTLTDDSVMEIAKA
-AARGDFQKLEKLNLSLNHEVTEEGYRNFFQILDNLPNLQELSISRLFTECTKAQAVTVK
ALSQCVLRLPSLTCLSMLGWLLDADDIGLLEATKERHPQSKHLLILWKWILPFSPIIQK-
--

--------DFEEMISEFDDD--LASEFSALLGVDALQVLKRQQEEDHKERMKMKKGFNSQ
MRSE--------------------------------------------------------
-------------------------------------------------A

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFESWPF
YAHGTPPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEDGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 330)

QSKKSSEEIAHYIKSYE-GFVHVTGEHFV-NSWVRRELPMNLHG---------------L
LSNLNYFPREAI-CPVEEL---GSQGLGR

PF00653 // ENSGT00500000044782_2_Domain_2 (330, 367)

YDTVQCFSCGGCMCNWEEGDDPLKDHSKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVTPAL-QSHCALPEAM--DSTGGSSREDAGAFLSTVCNKPTTA-L
ALRGL-LHFLLFPTDVAPSEAQGCERPPRGACVLSTELDQR-EAQWLQEAKS-LSEQLRA
A-YTKAAFRHI-NLP--EVCSSLGTDHLLGCDLSIVSKHISRPVQEALTLPEIFTNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
LCVEGETGSGKTTFLKKTAFLWASGCCPLLNRFQLVFYISLRSSRPDQGLASIIGAQLLE
TGARVSEVCLSDSIRQLKHQVLFLVDDYSGMESLPQAIETLITKNYLSQTCLLIAVHTNR
ARAIRPYLDTILEIREFPFYNTISVLRKIFSHNIIRVHKFINYFGKNEDLQGIHKTPLFM
AAVCTDWIQNPSD-QSFHDVAVFKSYMKYLSLKHE--AAAERLKATVSSCGQLALTGLFS
SCFEFSSEDLTEAGVDEGEDLTTCFMSKFTAQRLSPVYRFLSPLFQEFLAAMRLTELLGS
ERDEDQDLGLDYLRQVNSPLKAVSVY-NNFLKYISSHPSPKAGPKIVSHLLQLVSDKESL
ENLSENEDYGKLHPESSQRMQ-FVWGLWQIFPEAFLLFASENLLNAALKFAYESNAVTSC
SPFILQFLRGRTLALNVLN------LQYFGDHPESLLLLKSIKVSITGNNS--EQRIDFS
YMEKGF--EKVQPPTIDEDYASAFQSINECEKNLAEKEDIIKNYVAILRQAPPDISAGYW
KLSPKQYKIPRLEVGVANMGPADQALLQVLMEIFSRTVTRRASA--RWG-----------
----LLDCRMSRS-----------------------------------------------
------------------------------------------------------------
----------------------SA----------------------AHEGTTTEGGFVVS
PTAQALGSLRNLEELLLPTGDGIQQVAKLIVQQCLQLPCLRVFAFTETLDDDSVMEIAKG
-ATSGGFQKLENLDLSMNHKVTEEGYRNFFQVLDNLPNLKKLDVSRHLPECFQVQATTVK
ALSQCVSRLPSLTRLGILSWLLDEEDMKVINAVKERHPQSERLIVHWRWVVPFSPVIQK-
--

--MATQQKASDERISQFDHN--LLPELSALLGLDAVQLAKELEEKEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAAAGFYFTG-VKSGIQCFCCSLILFGASLKRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLASFRNWPF
YVQGISPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEITQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 360)

R
LDSFKDWPRESA-AGVATLAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCF

ENSGT00500000044782_2_Linker_2_3 (360, 540)

P
------------------------------------------------------------
-------------------------------------MAQG-EARWFQEAKN-LNEQLRA
A-YTSTSFRHM-SLL--DISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLE
KEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLQKFMVYFGKNQSLQKIQKTPLFV
AAICAHWFQYPFD-PSFDDVAVFKSYMERLSLRNK--ATAEILKATVSSCGELALKGFFS
CCFKFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYHLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLQMQ-LLRGLRQICPQAYFSMVSEHLLVLALKIAYQSNIVAAC
SPFVLQFLQGRTLTLGALN------LQYFFDHPESLSLLRSIHFSIRGNKT--SPRAHVS
VLETCF--DKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLEVNVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQ------------------
------------------------------------------------------------
---------------------------------VASLPNFISLKILNLEGQQFPDEETSE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEI---
------------------------------------------------------------
------------------------------------------------------------
--

--MATQQKASDERISQFDHD--LLPELSALLGLDAVQFVMEIEEEEQKERAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAAAGFYFTG-VKSGVQCFCCSLILFGASLSRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLASFRNWPF
YVQGISPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEITQYIQSYK-GFVDVTGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPRESA-VGVAALAKAGLFYTGIKDVVQCFSCGGCLEKWQEGDDPLDDHARCFP
KCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EVIPDL-QSRGELCELL--ETTSESNLEDSIAVDPI----V-----
-----------------------------------PEMAQD-EAQWFQEAKN-LNEQLRA
A-YTSASFRRM-SLL--DISSDLATDHLLGCDLSIASKHISKPVEEPLVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 608)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSFSSTRPDQGLASIICDQLLE
KEGSVTEMS---------------------------------------------------
------------------------------------------------------------
--------------------------------------TAELLKATVSSCGELALKGFFS
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LLRGLWQICPQTYFSMVSEHLLVLALKIAYQSNTVAAC
SPFVLQFLQGRTLTLGALN------LQYFFDHPESLSLLRSIHFSIRGNKT--SPRAHFS
VLETCF--DKSQIPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLEVDVNDIDAVDQEMLEILMTVFSASQHIELHVNHSRGFTESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSV
DLEGKINVFSVIPEEFPNFHHMEKLLIK-ISAEYDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTILASCKKLSEIK-FSDSFFQAV--PFVAILPNFISLKILNLEGQQFPDEEISE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKV
-AISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLHELDISRHFTECIKAQASTVK
SLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--------------------------------------------------MKMKKGFNSH
MRTEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFLTYD---TFRSWTPQDMAAAGFYHTG-VKLGVQCFCCSLILFCTRLSNL
PIESHKKFRPGCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDISMKSPEK-LRG-GKARYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRRE-LPMVSAYCNDS---IFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPHESP-GAVEALVRAGLFYTGKNDTVRCFSCGGCMSKWEEGDDPLKDHTKFFP
NCVF-LQNLKSSA-EEIPAF-QSHYTLPEVT--DTTGESNHEDPVAVHSTVA--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------VKFIQSSPNLHVFHLKCDFFS
NCEFLMTVLASCKKLREIE-FSGRCFEAM--PFVTTLPNFVSLEILKLEQQQFPDKETSE
KFAQALGSLRNLEELLLPSGDGIHHVAKLIVQQCLQLRCLRVLAFKETLDDDSVMEIAKG
-ATSRGFQKLETLDLSLNHKITEEGYRHFFQALDNLPNLKVLNISRHLPESIQVQATTVK
ALGQCVSRLPSLIRLHMLSWLLDKEDMKVINAVKERHPQSKCLIVHWQWVVPFSPVIQK-
--

--MATHGEASEERISEIDYE--FLPELSALLGVDAAQLAKSQEEEEHQERMKMKKGFNSH
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRSWTPQEMAAAGFYHTG-VKLGVQCFCCSLILFCTSLRKT
PIESHRRLRPGCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDIRVKSPEK-LRG-GKARYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSKEIAQYIQSYE-GFVHVMGEHFV-NCWVRRE-LPMASAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWPLESP-VAVEALVRAGLFYTGKNDIVRCFSCEGCILKWEEGDDPLEEHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNLKSSA-EAIPDL-QSHCALPEAM--STTDESNHEDPVNVHSMVA--------
------------------------------------DLAQR-AAQWFQEAKS-LSEQLRG
A-YTKATFRHI-NLP--EVCSGLGSDHLLGCDLSMVSKHISRPVQEALMLPEVLSNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKKTAFLWASGCCPLLNRFQLVFYISLGSTRPDQGLADIICGQLLE
AGGCISEVCLRIIIQQLKHQVLFLLDDYHGMDSLPQAIETLITRNYLTRTCLLITVHTNR
ARNIRPYLDTILEIKEFPFYNTISVLRKLFSHDLARVQKFIIYFGKNEDLQGIHKTPLFM
AAVCTDWFQNPSD-QSFHDVAAFKSYMKYLSLKHK--ATPEPLKATVSSCGQLALRGLFS
SCFEFSSDDLTEAGVDEDEDLTTCLMSKFSAQRLRPVYQFLTPLFQEFLAAMRLTELLGS
ERQEDQDLGLGYLRQINSPLKAINSY-NVFLKYVCSHPSSKAGPKIVSHLLQLVDDKESL
ENMSENEDYMKLHPETSLWMQ-FVRGLWLVSPDAFSSFISEHLLSIALNFAYESNAVAAC
SPFILQFLRGRTLALKVLN------LQYFGDHPESLSLLRGVKFSINGNKT--TSRIDYA
-FKTYF--EKMQPPTIDQDYTSAFEHISEWKKTSIAYEEAMKNHINIRPRAPPDISAGYW
KLSPKPYKIPRLEVRVASMGPADQALLGVLMEVFLASQNIELHLNHSSDFLESIRPALEL
NKTSVTKCSMCRLE-LSTAEQELLLDLPALQSLEVSETNQLPDQLFTNLDKFPSLKELSV
GLDGISDVLSVISGDFPNLHHMEKLSIQ-TSTESDLSKLVELIHNSPNLQVFQLECDFFS
NCESLMTVLASCKKLREIE-FSGRCFEAM--PFVTILPNFVSLKILNLKRQQFPDKETSE
NFAQALGSLRNLEELLLPSGDGIHHVAKLIVRQCLQLQCLRVLAFKETLDDDSVMEIAKG
-ATSGGFQKLETLDLSMNHKITEEGYRHFFQALDNLPSLQVLNICRRIPDSIQVQATTVK
ALSQCVSRLPSLTRLEMLSWLLDKEDMKVINAVKERHPQSERLTVFWKWIVPFSPVIQK-
--

------------------------------------------------------------
MRSEVQ

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFLSQPPGNALSTWAPLEMAAAGFYHTG-TKTAIQCFCCGLVLLARSIKRS
PYVEHKKYWSQCAF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

ILGKEVGNIPKYEIRVLYPRRRYSG---VTYKDLES

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLQSFADWPS
YAREAQPDLLAKAGFFFT--GIKDTVQCFACS--GCLGNWEDGDDPWKEHAKWFPECEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QKEKTRDEIKEYIQNYC-AFVGLTAKHFTPCTGKILD----SDPGDLELAINIYEDEGC

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 364)

R
LDSFQTWPAEAR-VDATSLAKAGFFYTGKMDIVQCFSCAGCLAEWKGDDDPWEGHAKAFP
HCN

ENSGT00500000044782_2_Linker_2_3 (364, 541)

HSDPERKTSL-E------KTHK--------EAEAESWHGKQMDHKDDLA--------
-----------------------------DTEV----LSSAMTNVAFEEHKL-LQEQLRR
A-YDDIHFRKMFPFG--DSAHFAIDLKTLFGDLAIVSKNISNLPLQQLTLPEVLENFQFI

PF05729 // ENSGT00500000044782_2_Domain_3 (541, 692)

TVVEGEAGSGKTALLRKIAILWASGCCPILSRYKLVFYLSLNSQNRDLSLVDIICNEVVG
LRGVLTQEFLETLCKHLKNEILFLLDDYDEMNAVPYDIEDLIQKNYLNKHCLVIAVRTNR
IGKIRQYAKTILGITDFPMTSTFYLLRKLFSHNTALVEDFFIQLRVEEAMHSMFKTPLFV
VALGTYWTQNPNG-SKFLDLVILKAYMLYTSLKYP--QACDRMKATVSACGELALRGLFT
SLFEFSEEDLSEVGVSGDDALWFGLLSKFTAQRLWPIYKFFHLSFQEYFAGLRMNELLSS
DVQEDVDRGLQYLQQINTFVKISGRY-QYILRYA-CVEASKAVPQIVTHLLSLPSCEKSF
ESQIKNDLYLQQTPELKLRQQELLSVTLTLFPEVYLSTFSDFVLELVTELAYQSNMTPAC
APIISQFLAGKEFSLDHFSSKGGFIRRFFLDYPDTLFLPSRFVMKTIGKEE----NLDMS
VEETVY--SNLGVPVVDQEYASGFRLFSDVSKQIKEDEDNINKFRTYFPRRFPNSRIVPF
LCKRGQEKIPHLQFSAKCINAFQTHDLENLAVLFSVFSHIDLKLQNCKGLLENIKPAIEQ
NLEYFKVCSIHNTA-LNLVEENLLLSMSSLESLEITGKASIPESLFLNLDKYTFLKELSV
DLPNCQNLFDIIPEGFKNLHDMEKFIICNIQFGSSSPRLAEFIRNFKKLSVFHLKHCSFS
DLGSLMDAMSSCKMLTELEIIELPFTDEDQFSLTAALPNFAALKILNLNGLNFTSKEIGI
ALGEALAPLENLEELSLPVGNGMSHAAKLIIQQCSHFPNLRKLEFNQYLSGEGLLEIAKV
-ATDGGFQKLEVLTLLVNHSITEEFWRRFFESLPQLPKLHDANFGRIFTHPIKCQAATVK
SFVQCVSRQQNLKVINMTGWLFDEKDLQMFDIMKEQHPQSKNLSLFWKWMLPVSPIINK-
--

--MAEHGEASEDQVSEFDGE--CLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---AFKSWTPQEMAAAGFYYTG-VRHGVQCFCCSLILFGTSLRKV
PIESHRKLRPQCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LSGKDVGNIGKYDIRVKNPETLPRG-GRARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSTEEINQYIQSYT-GFLHVAGEHFV-NSWVRRE-LPVVSAYSNDS---VFANEGL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDTFKDWPHESS-VAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPAL-QSHCARPEAM--ETTSESNHEDGVAVHSSVA--------
------------------------------------DLGQS-EAQWCQEARS-LSEQLRG
T-YTKASFRHM-NLP--EAYSSLGTDHLLGCEVFLISKHVSRPVQVALTIPEVFANLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRFQLVFYLSLRSIRADQGLADIICAQLLE
AGGCISEVSLSSGIQHLQHQVLFLLDDYSGMDSLPQALDTLITKNYLSRTCLLMAVHTNR
VRDIRPYLETVLQIKEFPFYNTVYILKKIFSHDIIRVRRFINYFGFHEYLQGIHKTPLFV
AGVCADWLQNPSD-QPFQDVTIFKSYMQYLFLKHK--ATAGPLQATVSSCGHLALTGLFS
SSFEFSSDDLIEAGVDEDEELSTCLMSKFTAQRLRPVYRFLSPLFQEFLAAMRLSELLGS
DSQEDQDLGLYYLRQINSPLKAMSIY-HTFLRYVSNHPSSKAGPKVISHLLQLVDEKESP
ENTSENEDYMKLHPETLLWSQ-CLRGLLQLSPESFSLFISERLLNIALNFAYQSNTVAAC
SPVILQFLQGRTLDLKVLN------LQYFWDHPETLLLLKSIQVLFNGNNR--VQRIDFS
LMDKSF--EKIQPPTIDQDYAFAFQPMSECQRNLAEKENIIKNYDDMKYQDPLNISSGYW
KLSPKPYKIPRLEVGVNNMGPADQALLHVLMEVFSASQSIEFHLFNSSGFLESIRPALEL
NKTSVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSGTSQIPDQLFHNLDKFLGLKELSV
RLDGTQDMLSVLPGEFPNLHHMEKLSIH-TSTESDLSKLVKLIQNSPNLHDFHLKCDFLS
NCESLMAALASCKKLREIE-FSGRCFEAV--PFVNILSNFASLKILNLRNQQFPDKETSE
KFAQALGSLRNLEELHLPTGDGIHQVAKPIVRRCLQLPCLRVLVFAETLDDDSVLEIAKG
-ATSGGFQNLENLDLTLNHKITEEGYRNFFQALDNLPNLQNLDISRHIPECIQVQASTVK
ALGQCVSRLPSLTRLGMLSWLLDEEDMKVINDVKERHPQSKRLTVHWRWVVPFSPVIQK-
--

--MAAQEKAPEERISQFDPA--VFPEMSAFLGVNALQYVKEIEEEEHRDREKMQKGFNPQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYT---TFSSWMPQEMAEAGFYFTG-TKSGIQCFCCSLILFGTSLQSS
PMGHHKKFHPDCEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIPKYDIRVQNPEDTLRKDDKARYQDEKA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFENWPF
YAQGTSPRELSAAGFVFT--GKRDTVQCFSCG--GCLGNWEDDDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSLEEITQYIQSYK-GFVDVTGEHFL-NSWVKRD-LSVASVCCNGS---IFVNEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LQSFKSWHPSSP-LGAAALAKAGFFYTGESDIVQCFSCGGYLHEWEEGDDPLEEHAKFFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QSVKSSA-EAIPDL-QSHDELSELT--ETTSESNLEESTAVSSI----VP----
------------------------------------EVAQG-EAQWFQEAES-LSERLRK
V-YTSAPFCHV-SLL--ELSSCLATDQWLDCDLSFALKHITNPVQEPVVLPEVFANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 691)

V
MCVEGEAGSGKTILLKKIALLWASGCCPLLHRFRLVFYLSLGSTRPEQGLASVIHGQLLE
TNVSVTEMGLRNIIQQLKNQVLFLLDDYKEMCSVPQVIARMIQKKHLSRTCLVITVHTNR
AKNIRRYLDTIIEIKAFPFYNTISILKKLFPGDLTRLRKLMVDLGMNQTWQGIQKTPLFV
AAVCASWLQNRFH-WSFHSVAVFKSYMECLFLKHK--TAADLLKATVSSCGELALKGFFS
SCFEFSDEDLIEAGIDEEEDLAMYLMNKFTAQRLRPVYQFLNPAFQEFLAGMRLTELLDS
DRQEDQDLGLHYLKQINSTLMAICPY-ANFLNCVSSHPSTKAGPKIVSHLLLLVDNKETL
ENLSENDDYLKHHPEISELMQ-CFRLMWQFSPQTYLSAASKHMLALAVKVAYQSNTVAAC
SPFILQFLQGRTLCLDVLK------LQYFFDHPESLLLLRSIQVSIGRNISFK---TDDM
PLERIL--DKSQAPTIDQDYASAFELESEWKQSLVEKQENIKRFHDTRLNAPPAISTGYW
KLPSKQYKIPLLEVHVTNTSAADQEMLKFLTEVFSAAQHIELHLNDSRGFIENILPALEQ
YRASFTKCCISQCE-LSAIEQELLLTLTSLESLQVSETTHIQDQLFLSLDKFLCLKELSV
NL--QQDVFSVISEEFLNLHHMEKLLIQ-ISSKCSSSKLVRLVENSPNLQVFHLECNSFS
DFESLVTALASRKKLEEIK-LSGHCFNAN--PFVIVLPNFISLKILNLRFQYIPDKETAE
KFAYALGSLNNLEELILPTGDGIHQMAKLIVQQCQHLQCLQVLQFFKTLDDDSVVEIAKV
-AINGGFQKLKHLDFSMNHKITEEGYRNFFQTLDNLPNLQELTISRHFKECIKVQATTVK
SLSQCVLRLPSLMKLNMLSWLLDAEDITLLTATIKKHPQSKHFTLFWKWILPFSPIIQET
IS

--SRTQQPPPDEKISPFADA--WLQEMSALLHIDAVQFAKIIEE-EQKDQEKMQKAFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---SYSLWTPQEMAAAGFYFTG-IKSGVQCFCCCFVLFGTKLYRH
LTEDHKKFHLDCVFLLGKDKGNIAKYDMRVKNPENTLRVDDKARYQEEKARLESFQNWPF
YAQGTSPRELSAAGFVFT--GPHIEVPRLGVESEPQLPAYTTAH----------------
---SNAESLTH-------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDEQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRHWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYK-GFVDITAEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLGTDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDKKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEYLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRFDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNNIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEEMLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIRNSPNLHVFHLKCNSFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

------MASPEPSVSQLDDT--DVQQASALLGRDVTEFIKEMVAEEEKARAKMRKGFNAQ
MRSETR

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 136)

RLKTFETYT---SCRCWAPQELAAVGFYYIKAEQSALQCFCCSLVLFHSSFRRS
PLEEHQKFQPDCAFLLGRDVGNIAKYDVRVQRPEQPWGG-EQVEHQEERARLASFQDCPF
CAQGISPRDLSAAGFVFTXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX---
---XX-XXXXXXXXXXX----XXXXXXXX-XXXXXXX-XXXXXXXXXXX---X-X----X
XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------
----------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXX

PF05729 // ENSGT00500000044782_2_Domain_3 (551, 693)

KTVFLKKIALLWASGCCPLLSRFQLVFYLSLGTARLEQGLTSMLRDQLLE
AGASVSETCLGHIIQKLKNQVLFLLDDYKEMSTVPYVIKKLIQKNHLSRSCLLIAACTHR
ARDIRWYLDTILEIGVFPFYHTIFILKRVFSDRLAYVEKFLYFFLMNKTLQEINKTPLFV
EGVCT-YFRYPLD-ECF-EVMTFKSYMDYL-FRKH--KDTGELKTVVSACGELALRGFFA
SCFKFSDEDLLEAGVGDNEELVMGLMSKFTAQRLKPVYHFLTPAFQEFLAGMRLTALLGS
ERQEEQELGLYYLKQINSPMMTLEAY-NNFLKYVCYHCSSKAGPIVVSYLLHLLE-KESW
ETLSENDDYLKHHPEMSEKMQ-FIRKLGQFFPQIYFSALSEHVLTLAIEVAYQSGTVVTC
SPLLQQFLQGQTLPLVLLQ------SQYFSDHPESLSLLKSVQVFLSGKHR--LRKPDLS
QLEACF--DKSQAPSIEQDCVPAFETVKEWEQNLAENEADMNRYLNSQRVTLPAICSGYW
QLSPKPHKIPLLEVHVSDVEAMDAEILSNLMTIFSAC-HIELHLTYSGGFIESIRPALEQ
YQALFTKCTIVNSE-LSTVEQELLLTLHSLESLEVSKITQGHEKLFANLDKFQCLKELSV
NLSDKEDVFAVIPENFLNHSHMEKLLIN-TLAEHSTSKLVKLIENSPNLHVFHLQCKLFL
SFESLMTALASCKKLHEIK-MFGPFFNTV--PFVA-LPNFASLKILNLKYQEFPDVEGSE
IFAHTLGFLSDLEELLLPYGKGIHPVAKPIIQQCQHLQHLRVFSLYQNLNDDSLMEIAKV
-AINGGFQKLEKLDLSMNDEVTEEGYRNFFQALDNLPNLRELAISRHFKNCIKAQATTAK
SLSQCMSCLQSLTHLTMLSWLLDAEDVALLNAMKERHPQLKYLTLNWNWLLPFSPTIKE-
--

--MATQQKASDERISQFDHN--LLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWIPQEMAASGFYFTG-VKSGIQCFCCSLILFGAGLTRL
PIEDHKRFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

ILNKDVGNIAKYDIRVKNLKSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLASFRNWPF
YVQGISPCVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
RSKKSSEEITQYIQSYK-GFVDITGEHFV-NSWVQRE-LPMASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPRESA-VGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRWFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVTPDL-QSRGEPCELL--ETTSESNLEDSIAVDHI----V-----
-----------------------------------PEMAQG-EARWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFADLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLE
KEGSVTEMCMRNIIQQLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFV
AAICAHWFQYPFD-PSFDDVAVFKSYMERLSLRNK--ATAEILKATVSSCGELALKGFFS
CCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYHLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLQIQ-LLRGLWQICPQAYFSMVSEHLLVLALKIAYQSNTVAAC
SPFVLQFLQGRTLTLGVLN------LQYFFDHPESLSLLRSIHFSIRGNKT--SPRAHFS
VLETCF--DKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYMDMQRRASPDLSTGYW
KLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHSRGFIESIRPALEL
SKASVTKCSISKLE-LSAAEQELLLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSV
DLEGNINVFSVIPEEFPNFHHMEKLLIQ-ISAEYDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTMLVSCKKLTEIK-FLDSFFQAV--PFVASLPNFISLKILNLEGQQFPDEETSE
KFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKV
-AISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLKELDISRHFTECIKAQATTVK
SLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MAAQGKPSEERVLEFDND--LAAELSALLHVDALQVLKRNDEEAHKDRMRMRKGFNAQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYD---TFRSWTPQEMAAAGFYFTG-VKSGVQCFCCSLILFCTSLRRL
PIESHKKFHPECEF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLGKDVGNIGKYDVRVRSPEKMLRG-GKAMFLEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 240)

RLESFQNWPF
YAHGTSPRALSAAGFVFT--GKRDTVKCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEF

ENSGT00500000044782_2_Linker_1_2 (240, 300)

L
KSKKSSEEISQYIQSYE-GFVHVTGEHFV-NSWIKRE-LPMASAYCNNS---VFANEDL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKNWPHDSP-AGVAALVRAGLFYTGMKDIVQCFSCGGRMENWKEGDNPLEDHIKFFP
NCVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSA-EEIPDL-QSHRDPPEAT--ETTSESNHEDSVAIHSTTAE-------
---------------------DDTECASSWASLLSTEAAQS-EAPWFQEAKS-LTERLRA
A-YISASFRRL-SLP--DICSSLRTDHLLGCDLSIVSKHISRPVQEVLVLPEILANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTAFLKKIAFLWASGCCPLLNRFQLVFYLSLTSTRPDQSLANIICDQLLK
AEGPVSEVCLSSSIQQLKHQVLFLLDDFHEMSSVPQVIEKLIKKNYLSRTCLLITVHTNK
VRDIRPYLDTILEIKEFPFYNTVYILRSFFSHNIICVCKFLNYFGMNESLQGIHRTPLFV
AAVCAHWLQNPSD-PPLDDVALFKSYMECLSLKHK--STAELLKATVSSCGQLALRGLFS
SHFEFSSDDLTEAGVDDDEDLTTCLMSKFTAQRLRPVYRFLCPEFQEFLAGMRLIELLGS
DRQEDQDLGVHYLRQINSPVKATSSY-NNFLKYVSSHPSAKAGPKIVSHLLQLVDNKESP
ENVSDNEDSLKLHPKTSLRME-FIRGLWQLYPEAFFLYISETLLTISLNFAYQSNTVAAC
SPVISQFLQGRTLALNVLN------SQYFSDHPESLLLLRSIKVSVNGEKR--KPRIEFS
DLEKGF--ETLQPPTVDQDYASAFEHMNECKKNLAKKEEIIKNYVDIQVKSPPRISGGYW
QLSPKQYKIPCLEVHVDNMGPADQEMLRVLMEVFSASQHIELHLYHSTGFIESIRPALEL
NKASVTKCSLCQLE-LSAAEQELLLTLPALRSLEVSRTNQLQDLILPNLDKFPCLKELSV
TLDGKADVLSVIPEDFSN-HNMEKLSIQ-TSTESDPSKLVKLIQNSPNLQVFHLKCDFFS
DFEYLMTELSSCKKLKEIG-FFGGCFEVV--QFVTILPNFISLKILNLKCQEFPNKETSE
NFAHTLGSLRILEELLLPHGDGIHHVAKLIVRQCLQLQSLRVLSFQYSLDDDSVMEIAKG
-AVSGGFQNLENLDLSLCHKITEEGYKNFFQALDNLPNLQELNISRHLPECMKVQAATVK
ALSQCVLRLPRLNSLKMLSWLLDEEDMKLLNAVKERHPQSKRFIIFWKWVLPFSPVIQK-
--

--MAEHGESSEDRISEIDYE--FLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 136)

RLKTFETYD---TFRSWTPQEMAAAGFYHTG-VRLGVQCFCCSLILFGNSLRKL
PIERHKKLRPECEFL

ENSGT00500000044782_2_Linker_0_1 (136, 171)

QGKDVGNIGKYDIRVKRPEKMLRG-GKARYHEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLESFEDWPF
YAHGTSPRVLSAAGFVFT--GKRDTVQCFSCG--GSLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 300)

QSKKSSEEIAQYIQSYE-GFVHVTGEHFV-KSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
MDMFKDWPQESP-VGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFP
ECVF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QTLKSSA-EVIPTL-QSQYALPEAT--ETTRESNHGDAAAVHSTVV--------
------------------------------------DLGRS-EAQWFQEARS-LSEQLRD
N-YTKATFRHM-NLP--EVCSSLGTDHLLSCDVSIISKHISQPVQEALTIPEVFSNLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLG
AGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNR
VRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEKLIIYFIDNKDLQGVYKTPLFV
AAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYK--ATAEPLQATVSSCGQLALTGLFS
SCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSS
DRQEDQDLGLYYLRQIDSPLKAINSF-NIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESL
ENMSENEDYMKLHPQTFLWFQ-FVRGLWLVSPESSSSFVSEHLLRLALIFAYESNTVAEC
SPFILQFLRGKTLALRVLN------LQYFRDHPESLLLLRSLKVSINGNKM--SSYVDYS
F-KTYF--ENLQPPAIDEEYTSAFEHISEWRRNFAQDEEIIKNYENIRPRALPDISEGYW
KLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFRLFNSSGFLESICPALEL
SKASVTKCSMSRLE-LSRAEQELLLTLPALQSLEVSETNQLPEQLFHNLHKFLGLKELCV
RLDGKPNVLSVLPREFPNLLHMEKLSIQ-TSTESDLSKLVKFIQNFPNLHVFHLKCDFLS
NCESLMAVLASCKKLREIE-FSGRCFEAM--TFVNILPNFVSLKILNLKDQQFPDKETSE
KFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLTFHDILDDDSVIEIARA
-ATSGGFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQELNICRNIPGRIQVQATTVK
ALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVILE-
--

--MATHGEASEERISEIDYE--FLPELSALLGVDAVQLAKSQEEEEHQERMKMKKGFNSH
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYN---TFRSWTPQDMAAAGFYFTG-VKLGVQCFCCSLILFGTSLRKT
PIESHRRFRPGCEFLLGKDVGNIGKYDIRVKSPEK-LRG-GKARYQEEEARLESFENWPF
YAHGTSPRVLSAAGFVFT--------------------------------------CEFL
QSKKSSEEIAQYIKSYE-GFVHVTGEHFV-NSWVRRE-LPMVSAYCNDS---VFANEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDTFKDWP---------ALVRAGLFYTGIKDSVRCFSCGGCMEKWEEGDDPLEEHTRFFP
NCLF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNLKSSA-EVIPDL-QSHGTLPEVT--DTTGESNHDDPVAVHSMVA--------
------------------------------------DLAQS-AAQWFQEAKS-LSEQLRG
A-YTKATFRHM-NLP--EVCSGLGTDHLLGCDLSMVSKHISRPVQEALMLPEVLSNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 690)

V
MCVEGETGSGKTTFLKKTAFLWASGCCPLLNRFQLVFYISLGSTRPDQGLADIICAQLLE
AGGCISEVCLSIIIQQLKHQVLFLLDDYHGMDSLPQAIEALITRNYLTRTCLLITVHTNR
AREIRPYLDTILEIKEFPFYNTISVLRKLFFHNISRLLEFMVYFGMSVGLQGIHKTPLFM
AAVCTAWFQNPSD-QSFHDVAAFKSYMKYLSLKHK--ATPEPLKATVSSCGQLALRGLFS
FCFEFSSDDLTEAGVDEDEDLTTCLMSKFSAQRLRPVYRFLSPLFQEFLAALRLTELLGS
ERQEDHDLGLGYLRQINSPLKAVGTY-SNFLKYVCSHPSSKAGPKIVSHLLQLVNDKELL
ENMSENEDYVKLHPETSLWMQ-FVRGLWQVFPEAFSSFVSEHLLSIALNFAYESNAVAVC
SPFIFQFLQGRTLALKVLN------SQYFGDHPENLQLLKSVKVSINGNKM--QPRAGFS
VIEKCF--ETLQRPTIDEDYASAFEHMKEWENNLAENEDKVRNFMNNRLQHPPNISAGYW
KLSPKPYKIPRLEVRVASMGPADPALLRVLMEVFSASQNIELHLNYSSGFLESIRPALEM
NKTSVTKCSMCRLE-LSAAEQELLLGLPALQSLEVSGTNQLP------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDQQKVKATMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGASLRRL
PIEDHKKFHPDCGF

ENSGT00500000044782_2_Linker_0_1 (135, 171)

LLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEA

PF00653 // ENSGT00500000044782_2_Domain_1 (171, 241)

RLGSFRNWPF
YAQGISPRVLSEAGFVFT--GKQDTVQCFSCG--GCLGNWEEGDDPWKEHAKWFPKCEFL

ENSGT00500000044782_2_Linker_1_2 (241, 258)

QSKKSSEEIAQYIQSYK

PF00653 // ENSGT00500000044782_2_Domain_2 (258, 367)

-GFVGIT------------------------------------
----------------------------IKDIVQCFSCGGCLEKWQEGDDPLDNHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPDEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEVAQG-EAQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLATDHLLGCDLSMASKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTIFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
VAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRNK--VAAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLTQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQMCPQAYFSMVSEHLLVLALQIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHVSINGKKT--SPRCDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQRTAPPDLSTGYW
KLSPKQYKIPCLEVHVNDIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLEISGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTVLASCKKLTEIK-FSGSFFEAV--PFVAILPNFISLKILNLAGRHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHCLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFRALDNMPNLQELNICRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

--MATQQEASDERISQFDYD--FLPELSALLGIDAVQLAKEMEEDQQKVQAKMRKGYNSQ
MRSEAK

PF00653 // ENSGT00500000044782_2_Domain_0 (67, 135)

RLKTFVTYE---PYSSWTPQEMAAAGFYFTG-VKAGVQCFCCSLILFGTSLRRL
PIEDHKKFHPDCGFLLNKDVGNIAKYDIRVKNLRSRLRG-GKMRYQEEEARLGSFRNWPF
YAQGISPRVLSEAGFVFT--------------------------------------CEFL
QSKKSSEEIAQYIQSYK-GFVDITGEHFV-NSWVQRE-LPVASAYCNDS---IFAYEEL

PF00653 // ENSGT00500000044782_2_Domain_2 (300, 367)

R
LDSFKDWPWESA-VGAAALAKAGLFYTGIKDIVQCFSCGRCLEKWQEGDDPLEDHTRCFP
NCPF-L

ENSGT00500000044782_2_Linker_2_3 (367, 540)

QNMKSSV-EVIPDL-QSPGEVCELP--ETTSESHLEDSIAVDPI----V-----
-----------------------------------PEAAQG-ETQWFQEAKN-LNEQLRA
A-YTSASFRHM-SLL--DISSDLTTDHLLGCDLSIDSKHISKPVQEPLVLPEVFASLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYVSLSSTRPDQGLVSIICDQLLE
KEVSVTEMCMRNILQQLKNQVLFLLDDYKEICSVPQVIGKLIQKNHLSRTCLLIAVRTDR
ARDIRRYLETILEIKAFPFYNTVFILRKLFSHNMTRLQKFMIYFRKNESLQKIQKTPLFV
AAVCAHWFQYPFD-PSFYDVAVFKSYMERLFLRSK--VTAELLKATVSSCGELALKGFFS
CCFEFNDDDLTEAGVDEDEDLTMCLMSKFTAQRLRPSYQFLSPAFQEFLAGMRLIELLDS
DRQEHQDLGLYYLKQINSPMMTVSAY-NNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESL
ENISENDDYLKHQPEISLKMQ-LIRGLWQICPQAYFSMVSEHLLVLALNIAYQSNTVAAC
SPFVLQFLQGRTLTLKVLN------LQYFFDHPESLSLLRSIHISIKGSKT--SPRLDFS
VLEACL--DKSQAPTIDQDYASAFEPMNEWEQNLAEKEDNVKSYMAIQCRAPPDLSTGYW
KLSPKQYKIPCLEVHVNGIDAVDQEMLEILMTVFSASQRIELHLNHSGGFIESIRPALEL
SKASVTKCSISKLE-LSAAEEELLLTLPSLESLELSGTIQSQDQIFPNLDKFLCLKELSV
DLKGNINVFSVIPEEFPNFHHMEKLLIQ-ISADCDPSKLVKLIQNSPNLHVFHLKCNFFS
DFESLMTALASCKKLTEMK-FSDSFFEAV--PFVAILPNFISLKILNLAGQHFPDEETSE
KFAYILGSLSNLEELILPTGDAIYQVAKLIIQQCQQLHRLRVLSFFQTLNDDSVVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFQALDNMPNLQELNISRHFTECIKAQATTVK
SLSQCVLRLPSLIRLNMLSWLLDADDIALLNVMKERHPQSKYLTILQKWILPFSPIIQK-
--

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------ETTSESNHQDTVAVHSTKA--------
------------------------------------EAAQS-EAPWFQEAKS-LSEQLRA
A-YISASFRRL-SLP--DICPSLRTDHLLGCDLSIVSKHISRPVQEVLVLPEILANLNS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGEAGSGKTAFLKKIAFLWASGCCPLLNRFQLVFYLSLTSTRPDQSLANIICDQLLK
AEGSVSEVCLSSSIQQLKHQVLFLLDDFHEMSSVPQVIEKLIERNYLSRNCLLIAVHTNR
VRDIRPYLDTILEIKEFPFYNTVYVLRSFFSHNITHLQEFMVYFGKNKGLQGIHRTPLFV
AAVCAHWLQNPSD-PPLDDVALFKSYMECLSLKHK--TRAELLKATVSSGGQLALRGLFS
SCFEFISDDLREAGVDDDEDLTTCLISKFTAQRLRPVYRFLSPEFQEFLAGMRLIELLGS
DRQEDQNLGLCYLKEINSPMKVINFF-NNFLKYVSSHPSAKAGPKIVSHLLQLANDKESF
KNIPENEDYQKPNPETSPWMQ-LIQEWWQVSPEAFSSFISETLVAIALNFACQSNTVAAC
SPVILRFLQGRTLTLRLLN------LQYFGDHPESLSVLRSIKISINGNKT--APRVSYS
DMEKCF--ETLQPPTIDQDYASAFEHMNEWEENVAKNEENIKNFKNIQCKPPPCLSGGYW
QLSPKQYKIPCLEVHVDNMGPADQEMLRVLMEVFSASQHIELHLYHSTGFIESIRPALEL
NKASVTKCSLCQLE-LSAAEQELLLTLPALRSLEVSRTNQLQDLILPNLDKFPCLKELSV
TLHGKADVLSVIPEEFPNLHHMEKLSIQ-TSTESDPSKLVKLIQNSPNLQVFYLKCDSFL
DFESLMTVLASCKKLKEIG-FSQGCFQAV--PFVSILPNFISLKILNLKSQQFPDKETSE
NFAHTLGSLRNLEEMLLPHGDGIHHVAKLIARQCLQLQSLRVLSFHYSLDDDSVMEIAKV
-AISGGFQKLENLDLSLCHKITEEGYRNFLQALDNLSNLQELNISRHLPECMKVQAATVK
ALSQCVLRLPRLNSLKMLSWLLDEEDMKLLNAVKERHPQSKRFIIFWKWVLPFSPVIQK-
--

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------------------------G

PF00653 // ENSGT00500000044782_2_Domain_2 (266, 367)

EHFV-NSWIKRA-LPMASXXXXXX---XXXXXXXX
XXXXXXXXXXXX-XXXXXXXXXXXXXXXIKDTVQCFSCGGCLKKWEEGDDLLEQHTRCFP
NCQF-L

ENSGT00500000044782_2_Linker_2_3 (367, 539)

QNMKSSA-EVIPDL-QSHGELSELM--ETTSESNLEDSAAVSSV----V-----
-----------------------------------PEMAQG-EAQWFREAKS-LSERLRK
A-YTNARFCHM-ALL--EVSSCPATDQLLGCDLSLASKHISSPMQEPVVLPEVFATLN

PF05729 // ENSGT00500000044782_2_Domain_3 (539, 693)

SV
MCVEGEVGSGKTVLLKEIALLWASGCCPLLNRFQLVFYLSLSSTRLDQGLADIISDQLPE
TEGSVTEMGLRNTIQQLKNQVLLLLDDYKEMCSVPQVIERLIQKNHLSRTCLLIAVHTNR
AKNIRRYLDTVLEIKVFPFYNTIYVLRKLFSHNMTRLQNFMIHFRKNENLQGIQKTPLFV
AAVCANWLQYPFD-ESFDDVTVFKSYMKCLFLKNK--TEAELLRATVSSCGELALRGFFS
SCSEFSDDDLIDAGIDE--DLAMFLMSKFTAQRLRPIYQFLNPAFQEFLAGMRLTELLDS
DKQ-DQDLGLYYLKQINSSLMALCPY-ENFLNYISCHTSTKAGPKIVSHLLLLVDNKESL
ENISENDDYLKHRPEISEKMQ-IIRQLWQLRPQDYFSLVSKHLFILAVKIAYQSNTVATC
SPFILQFLQGRTLTLDVLQ------LPYFFDHPESLLLLKSIQFSIRGNDRL--LRPDFS
VLATIL--DKSQVPTVDQDCASAFEPMNEWEQNLAEKEENIESFLNMRLSTPPDISTGYW
QLSPKQYKIPLLEVHVTGTDAVDQEMLRILMEVFSASEHIELHLMGSRGFIERIRPALEQ
FKASFTKCSISKFE-LSAAEQELLLTLPSLESLEVSEVTQLQDQLFPNLDKFLCLKELNL
D--DQQNV-FVIPEEFLNLHHMEKLFIR-ILAENGPSKLVKLIQNSLDLRVFHLKCNVFS
DFESLMTVLASCKKLEEIK-FSGPFFNAL--PFVTVLPNFISLKILNLQHQEFSDKETAE
IF----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--

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------------------------------------------------------------
--------------------------------------------YCNDS---VFANEELR
LDTFKDWPHTSP-VAVEALVRAGLFYT---------------------------------
-CVF-LQNLKSSA-EVSPAL-QSHCALPEAM--DSTGESNHGDPAAVHSTM---------
-------------ADL----------------------APR-EAQWFQEAES-LSEQLRR
A-YTKATFRLM-DLP--EVCSSLGTDHLLGCDLFIISKHISRPVQEAMMLPEVFTNLSS

PF05729 // ENSGT00500000044782_2_Domain_3 (540, 692)

V
MCVEGETGSGKTTFLKKTAFLWASGYCPLLNRFQLVFYISLRSTRPDQGLADIIGAQLLE
AGGCVSDMCLSSSIQQLRHRVLFLLDDYRGMDSLPQAIQTLITKNHLSRTCLLIAVHTNR
ARSIRPYLDTILEIQEFPLYNTVSVLQRVFSHDITRVEKFMEYLGKNEDLQGIHKTPLFV
AAVCANWFQNPSD-QSFHNVAVFKFYMKYLSLQHK--ATPEPLRATVSLCGQLALRGLFS
SCFEFSSEDLTEAGVDEDEDLTTCLMSKFTAQRLSPVYRFLSPLFQEFLAAMRLTELLSS
ERKEDQDLGLDYLRQINSPLKAMSVY-NNFLKYVSSHSSSKAAPMVVSHLLQLVDDKESL
ENMSENEDYGKLHQKTPQMMK-LIKEMWQVYPEVFSSITSEHLLSVALNIAYESNTVTAC
SPIISQFLRGRTLALNVLN------FQYFEDKPESLLLLRSVKVFIHGKKM--PPRLGYS
VMEKCL--ETLQPPTVDEDYAPAFEHMEEWVKNLAKNEDNVRNFINSQPLHPPNISAGYW
KLSPKWYKIPRLEIAVANMDPADGALLQFLMEVFSASQNIELHLNHSNGFLESIHPALEL
HKSSVTKCSMCGLE-LSTAEQELLLTLLALQSLEVSGTNQLPDQLFSNLDKFPNLKELSV
RLTGKPDVLSVIPGDFPNLHHMEKLCIE-TSTESDISKLVKLIQNSPNLHVFCLKDTFFS
DFESLVTVLASCKKLREIE-FSGGCFETM--PFVNILPKFVSLKVLNLTCQQIPDKETSE
TFAQALGSLRNLEELFLPTGDGIQQVARLIVRQCLQLQCLRVLAFHHTLDDDSVMEIAKG
-VTSGAFQKLETLDLSVNHKITEEGYRNFFQTLDNLPNLQVLNICRSLPERI-VQATTVK
ALSQCVSRLPSLTRLEMLSWLLDEEDLRVINAVKERHPQSKHLTVLWKWIVPFSPVIQK-
--

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-CQF-LQNMMAPA-EVIPDL-QSYGELSELT--ETASESNLEDSAAVSCT----V-----
-----------------------------------PEMVQV-EAQWFQEAKS-LSERLRE
A-YTNASFCRM-SLL--EVSSSLATDHSLGCDLSLASKHVSSPVQEPVVLPEVFANLN

PF05729 // ENSGT00500000044782_2_Domain_3 (539, 617)

SV
MCVEGEAGSGKTVLLKKIALLWASGCCSLLNRFQLVFYISLSSTRLDQGLANIICNQLLE
TEGSVTEKCLRNIIQQLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXPFYNTIYILRKFFPHNMTRLQKFMIHFGINSSLQGIQKTPLFA
AAVCANWFQYPFG-QSFDGVAIFMSYMKCLFLKHK--TSAELLKATVSSCGQLALKGLFS
SCFEFSDDDLIEAGADEDEDLTMYLMSKFTAQRLRPVYQFLDPAFQECLAGMRLIELLDS
DKQEDQDLGRYYLKQIKSSMITISPFCNNFLQYVSCYPSTKAGPKIVSHLLHLVDN-QSL
KNISENEDHLRHRPESLELVQ-LIRMFRQSSP-HYSSMVSKQVLALALNIAYQSNTVAAC
SPLILQFLQGRTLTLDILK------LQYFFDHPESLLLLRSIQLSIRGKIR--CPEIDFS
VLETCV--DKSQAPTIDQDCASAFEPMKEWEQNLAEKRENVMRFQDMKLNAPLDISTGYW
KLSPKQYKIPLLEVHVADSDGVDQEMLSALMTVFSASQHIELHLNNSRGFIESLRPALEQ
YKASFTKCSIHKSK-LSAEEQELLLNLPSLESLAVSETSHVQDQLFPNLDKFLCLKELSV
NLD-KQNVFSVIPVEFLNLHHMEKLLIQ-ISAEAGPSKLVKLIQNSPNLHVFCLECNFFT
DFESLMTVLASCKKLKEIK-LSGAFFKPI--PFVLVLPNFISLKILNLEFQQFPDKEISE
KFAYTLSSLNNLEELILPTGDGIQQVAKLIIQQCQHLQCLRVLSFSQTLNDDSIVEIAKV
-AINGGFQKLENLNLSINHKITEEGYRNFFQALDNLPNLQELTISRNFTECIKAQATTVK
SLSQCILRLPSLIRLNMLSWLLDEEDITLLNSMKERHPQSKYLIIHWKWVLPFSPIIRK-
--