Query Results 

MR---ALGWHKEKFC---F--VLFCSPYLEEMDLSAVQIEEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPISTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSTRF
SQLVEELLKITDAFELD--TGIQYANGYSISKLK---NSSEPLNE-EASIIQSVGYRNRG
KRLRQIESGNA--TLK-DS-LSVQLSNLGIVRS-TKKNHQTQPRNKSVYIELESDSSEET
VSKPDDC---SVRDQELLQTTSLGAGDEVSLD-S--STRAACEFSE-DVTNIDLHQCSNK
D-------------LDPIENHATGRY--PEKCQ----DISVSNLHVEPCGTDIHASSL--
QHENSSLLLTEDRMNVEKAEFYNKSKQSGLARSQQNRWAESKETCNDRQ-IPSTEKKVD-
-----PNT

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 607)

DSFCGRKKWKNQKSLCPENSR-ATQD-VPWMTLNSSIQKVNEWFSKTGEMLT
CDGTSDRRHESNAGAAVVLEV--SDEVDGCSSSSKEMDLVASDPHNALKCKSESDLSKPV
-ENNIRDKIFGKTY-QRKGSLPHLNHVTE---IIGTFIAEPQ-ITQ---EHPFT-NKLKR
KRR---TTCLHPEDFIKKADLTVTQKTSKNVNQGTDQMEP----DGLVMGITSNGQENET
QGNNLQKEKN---ANPVKSLEKGSVSTTKAKTISNSISDLELELNVHNS---QAPKK-SR
LRRKSSTRCVL---ALEP-VSR-----NPSPPACTEFQIDSCSSSEETEKNN-SNPTPVK
NIRKPQLTEDTEPA--ADSKKNKEPN-EQRRK--RRASDPFPEEK--FMPGLLTNCPSSS
KPQGPA------NPSPQRKEV---EK---LETSQMSDSTKDLRDLLLDGEQ-GLPTE---
RSEE-STSVSLVPDTD--------YDTQNSVSLLEANA---------V-RYAKTVSS-QC
MTQFVASDNPNEL-VHGSK-----DAGSGTECFK---HPLRHELSHI-QE-TIEMEESEL
DTQYLQNTFQASKRQSFTLFSKPRDPQEECVTACASSVSLRDMSPKVTSEGEQ-QEESRG
HEEAEISHIQAG-PATVGVPLPRQ--EGD-PGADTM--HAAVCSLCPSS-QYR-SNE---
----------NSHPKQSASPIMSSI-KTGHG-----------KTLSEEQSEKHTLSNEKA
MGNETFV-----QSTMHTISQNH-RKNGCQEANSG--------------SINEVPSSGEN
FQ---GQLGRNRRTKLNTVLPLGLMQPGVCKHSFPVSDYK-YLEI-------KKQ--E--
-GENVGAHFSSCLFSD-KLEQPVG-SGNVFQICSETPDDLL-DDVEIQEN--TSFGEVDI
MEKS---------AVFNGSVQR---RELSRSPSPLTHA--SLARNL-QRRSRKLESSE--
DSGSCEDEDLPCFQHLL-G---------------------------QVSKTPEPSS----
VVTQPLSEKAEGTQVPWK--SSVG-DSDNEVIL-IEASQEHHPSEDAKYSGSMFSSQPSA
VQGSTANTSSQDPL--FNL-SKQKSHQSEDEEDFLS--DKELISD-DEEMGTCLEE---D
NDQEEDIIIPDSAEAASGYESETNLSEDCS----QSDILTTQQRATMKDNLIKLQQEMAH
LEAVLEQQGDQPSVHSSSLTA-EPCA--PEDLPNAEQNLSGTA-----------------
----ILTSKNINENPVSRNPA--------CVSADKFQP---QPPDSSSSENKESREGRPS
LFKSPLA-GSRCSAHSRSGSLQNRNCPSQEELLWTVEAG---------------------
-KSEG-TPYLESGISLFSN----------RDPESESPKEPAYVC----------TTPAST
SART----ISQY--QVSDSFES-PA--ATHAH--T---------------AVIETVSKKK
--PELTSS-KGRANK

PF00533 // ENSGT00440000034289_0_Domain_3 (1996, 2070)

GISMVVSGLTPKEVMIVQKFAEKYRLTLTDAITEETTHVIMKTDA
ELVCERTLKYFLGIAGGKWIVSYSWVIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IQERKLLSVHEFEVRGDVVTGRNHQGPKRSR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

-EKLFKGLTICCCEPFT---NMPKDELEKMLQLCGASVVKELSSLTPDT---
GVHPIVIVQPSAWT-------E-ENGCPEIDQLC----GAHLVMWDWVLDSISVYRCRDL
DAYLVQNITHGHD-SSEPQD-----PND--------------

-------------------------------MDLSGVHVEEVQNILNAMQKILECPIXXX
XXXXXXXXXXXXXXXXFCMLKL---------LNQ-KRGPSQCPLCKNAITKRSLQESTRF
SQLVEELLKIIQAFELD--TGLPFASSYDFSKK-KN-NSPECQKD-EVSIIQSLGYRNRT
KKLPKVESKNP--ALQDNS-LSVQFCDLGIVRF-PRTTQQTQPQNKSVYIELGSDSSADT
VNKTDCH---SLENQ----ISLQEDSAKATLD-A--TEHAACLFSGKDTTNTEPLQSSSK
D-------------LTTIKKHATERH--PEKYQ----GTSISNLHVEPHGTNTHASSL--
QHENSSLLLTKDRTKVEKAELCDKSKPRGLARSQQGRWAESVKMYHDRQ-TPSTEGTEP-
-----LNVDSLCGRKQWKKQKPACPETCRD---A-NSWLTVNSSIQKVNEWFSRSNVILT
PDDSLGQQTESSAITTGTLQF--SNKADGYSVSSEKAGLLTSGSHNAVVCESKRIHSKPV
-ESTIKDKIFGKTY-QRKASLPNLSRVIED-PVREVSAVEPQ-I-----THPPT-NKLKR
KRRA--TIGLCPEDFIKKVDLTGVEKTPKERNQGTEQMMQ----NDQVMTITNGGNENET
KGDHVQKEKS---ANPTESLEKESAFSTKAEPISSSISNMELELNIHKS---KTPNM-YR
LRRKSSTRRVH---ALELVVSE-----KPSPPNHTELQIDNCSSSEET----NFGQVRVS
RRRKLQVIQDVP-----GT-RKNKPN-EQIRK--RQASDASPEFKLTNVPSVLTNCSSSK
EHHE------SVDPSLQRGEV---GEN--HDTVQASNTTTDPKGLPLSGER-SMQAE---
RSAE-STSNSLIPDTD--------YDTQDSISLLEART---------L-RNAKTAAN-GQ
ESESVATGNPQEVAPAYLE-----NTGDNPEGFK---DPLRSEDDHI-QETDTELEESEL
DTQYLQNTFKTSKRQSFALFSKPGDPERGCVTAHTHSSCLRNQSPKISLECEQ-KEENPK
KEESKARHWQAV-NSTVGFPVVCQ--KDK-PGDYAKCSIKEISKLCLSS-QFT-GNETGL
ITANKHELLHNPYHIPPISPIKLTV-KNTCE-----------LSPSEERSEEHSVSSERA
VGSESIF-----YSTMSTISQNYMKESARKEGGSSSVNEVSSSTNEVCSSINEVGSSGEN
IQ---AQPGRSRAPELNSVLRLSLVQPGVCEQSLPINNSK-LPEV-------KGPGEN-E
VVQAVNSNFYSYLVSE-TQEPPIG-SKNPSQICSETPDDLL-DDYDVMEN--TSFVDDGI
RERS---------AVFSKSVQR---GKISRTPSPLGHA--CLAQSH-QSEAEKLESKE--
ENVSSEDEELISLQQLLYG---------------------------KVTNRPSQSTRHGA
VATEGVSVKSE-NLVLSE--NSFD-DSSSEIIL-PGASQEHDISEEIECSGSLFSSQHGA
VEEVNENANSQDSFLMFDPLPKQTRHESEEQ-QDVS--DKELASD-DDERANGPAE---D
N-LQEQNVDANLGEAASGYESETSLSGVHSELSSQSEILTTQQRDAMQDNLLKLQQEMAR
LEAVLEQHGSQSPHTSPSLLALESCV--SEDQLHLQQNTSG--K----------------
A---ILTSENHSESPVSHYPE--------SLSVDKFPV----SVLGSNSNNIGPAAESCP
ISESQLF-SSGDYMDRHPSGLQNNNCPAPEGPAEDVGVEEQQLEKSEPQDSRSQSYLPT-
QETEG-TSYLESGISLFDD-------P-EHSP-EDRAPGP-----------------API
STLK----LPEF--EVAEFSKG-S------ATE-SAGYK-----------VGKQSVRLGK
--PELASS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-TERSDKAMSMVVSGLTSKEFSLVQKFAKKFHITLNNVITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWIVSYFWVIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

MKERKMLDEXXXXXXXXXXXXXXXXXXXXX-
----XXX

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

XXXXIFKGLEICCY-PFT---NMPTDQLEWMVQLCGASVVKELTSFTVGT---
DSHPVVVVQPDAWA-------ED-DGFLAIGQMC----AAPVVTREWVLDSVALYQCQEL
EPYLIPQCHHSHC-----------------------------

-------------------------------MDLSAVRIQEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQKSTRF
SQLVEELLKIMAAFELD--TGMQLANGFSFSKK-EN-NSCEHLND-EVSIIQSVGYRNRV
RRLPQIEPGNA--TLK-DS-LGVQLSNLGIVRT-VKRNRQTQPRNKSFYIELESDSSEET
VTKPGDC---GVRDQELLQIVPQEAGDEGKLH-S--AEEAACEFSE-GKRNIEHHQCSD-
D-------------LNPTENHATERH--PEKCQ----SISVSNVHVEPCGTDAHASSL--
QPETSSLLLTEDRMNAEKAEFCNKSKQSGIAVSQQSRWAASKETCNDRQ-VPSTGEKVD-
-----PNT

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 608)

DSLCDRKKWTHPKSLCPENSG-ATTD-VPWITLNSSIQKVNEWFSKTGEMLT
SDSASARRHESNSKAAVVLEV--SNEVDGGFNSSRKTDLVAPNPHHTLMCKS--DFSKKV
-ENNINDKIFGKTY-QRKGNHPHLNHVTE---IIGAFITEPQ-ITQ---EQPFT-NKLKR
KRR----TCLQPEDFIKKADSTDVQRTPENINQGTDQMEP----NEQAMSTTSNCQENKT
AGSNLQKGKN---THPVEASRKEPAATAKAKSISNNISDLEVELNVHSS---KVPKK-NR
LRRKSSIRCAL---PLE-PISR-----NPSPPTCAELQIDSCGSNEETKKN-NSNQKPAR
HLREPQLIEDTEPA--ADAKK-NEPN-EHMRK--RRASDAFPEERLMNKADLLTSCSSPR
KSQG------PVNCSPPRKGV----EQ--LETCQMPGNAIELGDLVPGGEPSGKPTD---
RSEE-SSSVSLVPDTD--------YDTQNSVSVLEANT---------V-RYARTGSV-QC
MTQFVASENPKELIHGSN------NAGSGTECFK---PPLRHALNHS--QETVEMEDSEL
DTQHLQNTFQVSRRQSFALFSKPRSPQKDCA----YSVPSKEPSPKVTAKGKQ-KD-CQG
QEEFEISHVRAV-TAMVGLPMPCQ--EGKLDA-GAVC--DGVSRLSPPS-HYR-SIENGL
SATGKSGVSQKSHFKQSVSPIRSSI-KTDNR-----------KPLTEGRFEKHTSSTEKA
VGNENIV-----QSIVHTISLNNRG-NACQEASS--------------GSMNEVCSSGEY
FP---GQLGRNRGSKVNAMFPCPSTQPGVCKRSAPVGDKY-LEIK-------KQEG----
--EAVGADFSPCLFSD-HLEQPMR-SGKIFQVCSETPDDLL-DDVEIQEN--TSFGEGDI
METS---------AVFNGSILR---RESSRSPSPVTHA--SKSRSR-HRGSRKLESSE--
ESDFSEDEDLPCFQHLLSR----------------------------ISNTP-ELTRCSS
VVTQRMPDKAEGTQVPWK--GSIS-DCNNEEIL-IEASQEHQFSEDPRCSGSMFSSQHSA
AQGSTANANSQDP--NFNPPSKQRSHQSGNEEAFLS--DKELISD-NEEMATCLEE---D
NDQEEDSIIP--DSEASGDESETNLSEDCS----QSEILTTQQRATMKNNLIKLQQEMAH
LEAVLEQRGNQPSGHSPSLLA-DPCV--LEDLPDPEQNMSG--A----------------
A---ILTSKNINENPVRQNLK--------STCDDKFQP---QHPEGPTSGENESGMGRP-
PFKSPLA-GSRGSAHGHSRGLQNRNFPCQEELLQPAESEK----SSEPHSLTGRSSLPR-
QDLEG-TPYLESGISLFSS-------R---DPESESPKEPAHVG----------TTPAST
SALK----ISQG--QVAESFRS-AA--AAGADT-----------------AVVGIVSKIK
--PELTCS-KERADREISMV

PF00533 // ENSGT00440000034289_0_Domain_3 (2001, 2070)

VSGLTPKELMIVQKFAEKYRLTLTDAVTEETTHVIIKTDA
EFVCERTLKYFLGIAGGKWIVSYSWVVQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IQERKLLNVHEFEVKGDVVTGRNHQGPRRSR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

RE-KLFKGLQVYCCEPFT---NMSKDELERMLQLCGASVVKELSSLTHDT---
GAQPVVIVQPSAWT-------ED-SYYPDIGQLC----KARLVMWDWVLDSLSSYRCRDL
NAYLVRNITCVPD-SSEPRD-----SND--------------

----------------------------------------------------------L

PF00097 // ENSGT00440000034289_0_Domain_0 (60, 105)

E
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIVHAFELD--TGLQFANSYNFAKK-EN-NSPEHLKD-EFSIIQSMGYRNRA
KRLRQSPT-----LQE-TS-LSVQLSNPGIVRS-LRTKQWIQPQNKSVYIDLGSDSSEDT
INKKTYC---SVGDQELLQITPQGTRDETSLG-S--AKKAPCEFSEKDITNTEHHQSSNN
N-------------LNTTEKHATERH--PEKYQ----GSSVSNLQVEPCGTNTHASSL--
QHENSSLLLTKDRLNVEKAEFCNKSKQPGLARSQHNRWAKSEETCNDRQ-TPSTEKKVD-
-----LDA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLHGRKEWNEQKPPCSENPRDDTED-VAWITLNSSIQKVNEWFSRSDELLT
SDDSHDKGSESNAKVAEALEV--LNEVDGYSSSSEKIDLLASDPHDALICKSERVHCKSV
-ESSIEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-IAQ---EHPLT-NKLKR
KRRV--TSGLHPEDFIKKADLAI-QKTPEKINQGTNQMEQ----NDQVMNITNSGHENKT
KGDSIQNENN---PNPVESLEKE-SFRSKAEPISSSISNMELELNIHNS---KASKK-NR
LRRKSSTRHIH---ELELVVSR-----NLSPPNYTEVQIDSCSSSEEIKKK-NYNQMPVR
HSRKLQLMEDKERS--TGAKKSSKPN-EQTSK--IHASDTFPELRLTNIPDSFTNCSNTN
ELKE------FVNPSLPREEK---EEK--LETVKLSNDAKDPKDLLLSGES-VLQVE---
RSVE-SSSISLIPGTD--------YGTQESVSLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKELIHGCSK-----DTRNGTEGFK---YPLGPEVNYS-QETSIDMEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEKECATFSAHSRSLKKQSPKVTLECEQ-KEENQG
EKESNIEPVETV-NITAGFPMVCQ--KDK-PVDYAK-CIEGGSRLCLSS-QFR-GNETGL
IIPNKHGLLQNPYHIPPLIPNRSFV-KTKCK-----------KNLLEENSEEHSVSPERA
MGNKNII-----PSTVSTISHN-NRENAFKETSSSSINEVGSSTNEVGSSTNEVGSSDEN
IQ---AEIGRNRRPKLNAMLRLELLQPEIYKQSLPISNCK-HPEI-------KQQE-HEE
VVQTVNTDLSPCLISD-NLEQHMG-SSHTSQVCSETPEDLL-DDGEIKED--TSFAEYGI
KETS---------AVFSKSVQR----ELSRSPSPFTHT--HLAQVY-QRGAKKLESSE--
ENLSSEEEELPCFQHLLFG---------------------------KVSNTP-QSTRHST
VATECLSKNTEKNLLSLK--SSLN-DCSNQVIL-AEASQEHHLNEETKCSGSLFSSQCSE
LEDLTTNTNTQDPFLIDS--SKQMRHQSESQGIGLS--DKELVSD-DEEKGTDLEE---D
N-QEEQSMDSNLGEAAFGYESETSITEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQDGSQPSHSSPSIIT-DSSA--LEDLRNPEQSTSE--K----------------
A---VLTSQKSSEYPISQNPE--------GLSADKFEV----SPDSSTSKNKEPGVERSS
PSKCQSL-DDRWCVHSCSGSLQNGNYPSQEEL-VKVDVEEQQLEKSGPQDLMEPSYLPR-
QDLEG-TPYLESGIRLFSD-------DPESDPSEDRAPESSHAG----------SIPSST
STSK----VPQF--QVAESAKS-LA--AAH-TN-TAGCN-----------AVEESVSRKK
--PELAAS-TERVNKRMSMVVSGLTPE

PF00533 // ENSGT00440000034289_0_Domain_3 (2008, 2070)

EFVLVYKFARKHHITLTNQITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

IKERKMLNEHDFEVRGDVVNGRNHQGPRRAR
ES-----QG

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2211)

RKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GIHAVVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DAYLIPQIPHSHY-----------------------------

-------------------------------MDLPAVQIEEVQNVLHAMQKLL

PF13923 // ENSGT00440000034289_0_Domain_0 (54, 105)

ECPICLD
LIKEPISTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKSEITKRYIIFWF--
PRPI--------------------------------------------------------
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-------------------------------MDLSADRVEEVQSVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-RKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNDITKRSLQESTRF
SQLVEELLNIIHAFELD--TGLQFANSYNFSKK-EN-NSPEHLKE-EVSIIQSMGYRNRA
KRLRQSEPENP--NL-ETS-LSVQLSNFGIVRS-LRTKQQIQPQNKSVYIELGSDSSEDT
VNKASYF---SAEDDELLGITPQGARAEASLN-P--AKKASCEFSE-DITNIEHRQPSNK
D-------------LTATEKHATEKH--PEKYQ----GISVSNLHVEPCATNTRASSL--
QHENSSLLLTKGRMNVEKAEFCNESKQPGVARSQQSRWAESKETCNDRQ-TPSTEKKVV-
-----LNAD

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

PLCRRK-LSKQKSPCSDSPR-DSQD-VPWITLNSSIQKVNEWFSRSDEMLT
SDDSHDEGSESNPGVAGA-EV--PNVVDGYSGSSEKIDLMASDPHDALICESERVHTKPV
-ESNIEDKIFGKTY-RRKASLPNLSHTSED-LIIGACAIEPQ-ITQ---AYPLT-NKTKR
KRRS--TAGLHPEDFIKKVDLAIVQKTPEKLIEGTDRIGQ----NGHVMNRTNNGPENGT
KGDYVQKEKN---AKPTESLEKESAFRTKAEPISSNISNMESELNSHSS---RAPKE-NR
LRRKSSTRHMR---ALELVVNR-----NPSPPDHTELQIDSCSSSEEMVKRKSSEQMLVR
HSKTLQLVENKEPA--PGAKKRNKPS-KQINK--RLASNTFPELNLTNIPGVFTNCSSSN
TLQE------FVNPGIQREEL---EES--RGTIHVSDRTRDPKALVSSGGR-SLQTE---
RSVE-STSISLVPDAD--------YGTQDSISLLEADT---------L-GKAKTAPN-QR
VSLCAAIENPKEAIRGCSK-----DTRNGTESFT---DPLRREDNHT-QETSIEMEENEL
DTQCLYNTFKVSKRQSFALFSNPGNPEKECATAWARSTSLRKQSPKVALEYEQ-KEENQG
KKQSEIKHVQAV-RATAGFSAVSQ--KVEKPGDYAKCSIKGVPGLCQSS-QFR-GNETEL
FIANNHDISKNPYHIPPLSPIRSSV-NAVCK-----------KNLSEEKFEQRSMSPERA
VGNESVI-----QSTVNTISQNNIRENTFKEVSSSSVNEVGSSANEVGSSINEVGSSGEN
IQ---TELGRNRGPKLSAMLRLGLMQPEVYEQSLPISNCK-CPEM-------KRQGENEG
VVQSVNADFSPCLISD-NVEQPME-SSRASQVCSETPNDLL-NGDEIKGK--ISFAESA-
KERS---------AVFGKSVQK---GEFRRSPSPLDHT--HLAQGH-QTETRKLESSE--
ENVSSEEEELPCFQHLLFG---------------------------KVTSIPSQSTSHNA
IATEGLSKKTEANLESLK--DSLH-DCSNQVTS-AKESQEHHLSEEARCSGSLFSSQCSA
SEDSAVNTNTQDPFLMFDPPSKQVRHQSENV-DVLS--DEELVSY-DDEREPGLEE---D
NHEEEQSVDSNLGEAASGYENETSLSEDCSGVSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHESQPSNSSPALIR-DSYA--PEDLFNLEQNTSE--K----------------
A---VLTSEKSSDCLISQNPE--------SLSADKFQV----SLDSSTSKTKEPGMRRSS
PSQSRLL-DTRQCVRSHSSSLQSTNCLSQKELIKAVDGEELQLTKSEPRDFMEQSYLPR-
QDLEG-TPYFESGISLFSD-------DPESDFSVDRAPEPVHVS----------SMPTST
SALK----LPQF--QVEESAKS-TA--AVHITN-TAGYN-----------KREDIEGKER
--PEMMSS-TKRVNKRISMVAS

PF00533 // ENSGT00440000034289_0_Domain_3 (2003, 2070)

GLTPKELVLVQKFARRHQITLTNVISEETTHVIMKTDA
EFVCERTLKYFLGIAGGRWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----R

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFGGLEICCYGPFT---NMPTDQLEWMVRLCGASVVKRPSLFTLSK---
ATHPVVVVQPDAWT-------ED-SGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPRATADLSQPCV----------------------

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------------------------------MGS-LRTRQQTQPQNKSVYIELGSDSSEDT
VNKAYYC---SMRDRELLLFTPQGTKAEASSD-STKQSNATCEVSEKGITDTNCPQPSRK
V-------------ENAVKERAAKRQ--PERHQ----GGSVSDLRVEPCGTKTRASSL--
QRANSRLLLTEDRMDVEKAEFRNKSKQPGPRRSQQSRWAKSKGSCANRQ-TPRTEQEAE-
-----RIAE

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

PLHEREEQKKQKPPCSEDLR-ETQD-VPWITLNSSIQKVNEWFSRSDEMVT
FDDACDRESEPDAEEAGALED--PKDLDDPSGSSVKIDLLASDPLSVATCASERGCPRAV
RGG-MEDKVFGRTY-GRKASLPSLSHTAEN-RTVRALAAEPP-LTQ---KRPLT-STLKH
KRRT--TSCLHPEDFIKNAGLAVAENTPGKINQGTKQTEK----SRQVTHIPNNGHENET
KGGDVQRQKS---PSPVQSLEKESASRTRAEPQSSSVSNVGLELKVRLS---EAPRD-NR
LRRKSSARHVP---Q-------------PSPPDHT-----NSTSSEEIK-GKNSQQVPVR
HGRKLPFTGDLEAS--AGTKEEKPGE-QGRKR--SRAGEAIPEPRLAPVPSSVTNSSSPD
KLTE------FVHPSPQKEEI---EEN--PETLQGSGSTRDPKDPVLSGEK-CVQTE---
RSAE-STSVSLVPDTD--------CSTQDSVSLLVADS---------C-RRARRVAH-QC
VAQYVAVTKPEKLLP-ASK----DT-GDCAEGFK---EPLGREVSCT-QGANTEMEDSEL
DTQYLQNTFQSSKRQSFALFSNPGNTEKGYTTVCAYFESFEKQSPEVTPEYEQ-PWESQG
EEEPKVRHVQAV-ASTTGAPVLSQ--NDQ-PGAGVKCSVTELSRLH-PS-QVG-GNEAEH
ITADKHGILRNLYLMPSISPVRS-LVRSTCK-----K------TCST--------SLEEA
VGSESIL-----QSTGG---HSLSRACAAQEASS-------GSGNGVGSSTDEVGPSSEN
IQAQ---LGRNRGPELDAVLRLGLMQPEASKQSLPVGNCK-PPEVQR----RGE---SGV
AGRAVCADFSPCRIVD-SKEQPVG-GSPASQICSETPDGLL-GDEDSKED--TSLAEGDI
KETS---------AVFSKGAPR---RQLSRSPSPVTHT--AFSRSR-QRRVRKLESSE--
EHMSSEDEELPCFQHLIFG---------------------------KGTETP-QSTRPST
VATEHVPKGTEGSLVSLK--NGSR-DCTHEPA-LAKVSPEPQQGEDIRCSGSLFSSQCSA
PEDSAANTNSQDPFLVLHPRAEQRECPSGSQQVVLS--DKDSVSG-GGDREADLEE---D
SHHTGQSARPHLDEAASGSESEANCSDGCSGLSSQSSILTTQQRDTIQDNLLKLQQEMAH
LEAVLERHGSPHSGTSASIVL-DSCP--LEELPTPGCHIAA-------------------
---KGLTAEGSNEYPGSHSPP--------ALSADVYQV----SPDCPTSE-HEPGAAGAS
PPKSLVA-DGRWSTHSEPRGLRDRGCPAPEQLMDAASVEEEELGESGPQRPAAPAHLPS-
QEPVG-TSDPESGNGLFSD-------NPEPEAPEDGGPGPAPTC----------GAPAST
SALK----LSLV--QVAPHGSS-PA--AAQTSN-PASGA-----------SREGGVSR--
---------EELVHRRVSMVVSGLTSR

PF00533 // ENSGT00440000034289_0_Domain_3 (2008, 2069)

EWMLAQKFARKYHMRLSGLVTEETTHVVMKTDA
DLVCERTLKYFLGIAGGKWVVSYFWVTQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2109)

SMKERRVLDERSFEVRGDVVNGRNHQGPRRAR
ES-----E

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFSGLDVCCFGPFT---NMPTDQLEWMLRLCGATVVREPSSLPLGA--Q
GAHPIVVVQPDAWT-------ED-SGFLALEQLR----QVPVVTREWVLDSVALHQRQEL
DAYLVPWGPHGPCCLRPPSALGPQDPEDVLQKWPCPGAVSLP

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCML---------KLLNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRYI------
---------ICACFLSD--TENNIANSYNFAKK-EN-NSPEHLKD-EVSLIQSMGYRNRA
RRLLQSEPENP--SLQETS-LSVPLSNFGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 604)

DTLYERKERNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IEDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PDPIESLEEEFAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPRSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKAPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEQN-KC
VSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGGDVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSKSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFPVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVRS-FVKTKCK-----K------NLLEENSEEHSVSPERA
VGNENII-----PSAVSTISHNNIRENAFKGASSSNSNEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPQLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHVSEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQITRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKGSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NPEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIVT-DSSA--LEDLRNPEQSTSEKGPRNINFF--------ST
LSQLVLTSQKSSEYPISQNPE--------GLSADKFKV----SADSSTSKNKEPGRNYIS
KKKK-----ISWKVANT--------------------------------------CGPS-
YSGEG-TPYLESGISLFSD-------DPESDPSEDRALESAHVG----------SIPSST
SALK----VPQW--QVAKSAQS-PA--AAHNTN-TAEYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEV---------------------
--------------------------------NQLEWMVQLCGASVVKELSSFTLGT---
GFHPVVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DAYLIPQIPHSHY-----------------------------

----------------------------------------------------------

PF00097 // ENSGT00440000034289_0_Domain_0 (59, 105)

LE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKTNITKRGLQESTRF
NQLVEELLKIIHAFELD--TGLQFANSYNFSKK-EN-NSPEHVNE-EVSVIQSTGYRNRA
KRLRQSEPEDL--TLQESS-LSAQLSKSRNVRS-LKTKQQTRRRNKSVYIDLGFDSXXXX
XXXXXXX---XVLDHGLLQIVSQKAKADASLH-A--TKKAACVFPEKDITDFEYQQFSDR
D-------------LNTIKKPATKRH--LEEYQ----DISVSNLNEEACGTDTCASSL--
QHENSSLLLTKDRMDVEKAEFCSKSKQPGLARSQQSRWAESMETCNGRQ-ILRTEKKVE-
-----TNADPLYGKKEGNKQKPPCSESRT-DTQD-IPWVTLNNSIQKVNEWFSRSDNLSD
SP---SEGSELNGKVAGPVKL--PGEVHRYSSFPENIDLMASGPPG------ERIPCKPP
-KSNIKDKIFGKTY-QRKGSLPHLSHITED-LVKGTIATQPQ-IAR---EHPRT-NKLQH
KR-R--TSGLHPEDFIKKADLTVVQKASEKINQETDKVEQ----SGQVINIGNGGHENET
NDDYVLKEKN---GNPAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXX-XX
XXXXXXXXXXX---XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXX--TGAKKSNKPK-EQIYK--RHTSNPYPELNLTSTAGFITVCSSSD
NLQE------PVNPSLQGEEI---EEN--LATVQMSNTAKEPQDLELNGGR-VLQTK---
RSVE-STSTSVIPDAD--------CGAQDSISLLEADT---------L-GKAKTAPN-QG
AGQCSAIENPNELIHGSPK-----DTRNDIEGFK---DPLRCEVNPI-QEICVEMDENEL
DTQYIQSTFKVSKRHSFALFSNP---EKECATSYTHSKSLRKENPKVTLQRGE-EEENQG
NKESKIKHV----HTTASCPEVCQ--EDTKPSDRTNCSVKGLPRLCHSS-QFK-GSESEL
ITEGEHGIAQNPDQMPSSSPIRSSV-NSKCN-----------KNLSEERFKEHKILLERT
TGNETIV-----QSTVSTGSQDNIRGSASKETSSSA--------------HVRVGSSSEN
IQ---AEISRNXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX-------XXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXXX--XXXXXXXX
XXXX---------XXXXXXXXX---XXXXXXXXXXXX--XXXXXXX-XXXXXXXXXXX--
XXXXXXXXXXXXXXXXXXX---------------------------XXXXXXXXXXXXXX
XXXXX---XXXXXXX-XX--XXXX-XXXXXXXX-XXXXXXXXXXX-XXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX--XXXXXXX-XX-XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQKDTMQDNLIKLQQEMAE
LKAVLEEHGSQPSHRSPLLEV-A-SA--PKDLLNPEKNTSAKG-----------------
F---ILASEKSNERTISKNPE--------GLSANKFEV---SSGS-AASKNKEPGMERSS
S-RCQLL-DNRGDVHSHPRSLQNRNSQPQKELADIVDMEEQQVGKSEARESVEQSYLPR-
QDLEG-SPDLESGVSLFSD-------YPESDPSEDGAPAPGHVS----------SMPASS
SALK----LPQF--QVAQSGS--TSATNTHVSA-TADYN-----------VREASVTPEK
--SGVISS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-TERVSKRFSMVASGLTQKEFMLVHRFARKYHCALTNQITEETTHVIMKTDA
EFVCERTLKYFMGIAGGKWIVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

LKERKMLDECDFEVRGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

WDRKIFTGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKDPLSFTLNV---
GTYPVVVIQPDAWT-------ED-SGLHAIGQLC----EVPVVTREWVLDSVALCQLQEL
VTYRILQIPSHH------------------------------

-------------------------------MDLSAVPVQEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRWYLHLLK-
-----EW-----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------MDLPAVHCEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKRPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNEITKRSLQESTRF
SQLVEELLKIIDAFELD--TGLQFANSYTFSKKS---NNSEHLNQ-ETSIIQSTGYRNRA
KRLRQTQLGNP--TLG-GS-LSNQLSNLGIVRL-PKRKK--KPQEKSFYIDLGK------
-----GL---AVRDEEFLQITPEGARPEPNMD-S--AKKAACEVSEKDITNTEHHQPSNK
D-------------LNAVENHVAEKH--PEKYQ----GVSISNLHMEPCGTDPHASSL--
QWENSSLFLTKDSMNVEKAEFCNKSKQSGLEKIQPSRWAKSKEACHDGQ-IASPERKVG-
-----LSAG

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

PLSGRQTLNEQKPVCSETPA-GNEG-PAWLTRNSSILKVNEWFSRSGELLT
FADTDSVRGESDAEVAGAVQV--VGEVSGYSCSSKRTGVPDTDACPAVLCQSETVCSKP-
-ESDIKDKIFGKTY-HKKAGLTNLNHVTEN-LIPGAFAAEPQ-ITQ---EHPST-NKLKR
KRRT--PSCLQPEDFIKKADLTVVQKTCENISQGTDQMQQ----NGQVKDITNDGHKNET
ECDDIQKEGN---ANPIKSLSKESAFRSKAEPISSSISNLELELNVHHS---RTPKK-NR
LRRKSSTRGNL---VLEL-VSD-----NPSPPTHTELQIESCSSSEEMKEKKDSIQIPFR
QGMEPPLG-AAEPV--AGGRKRKEPS-ERLSR--ICAW-----NV--SLESTLGNIPGAT
NPSGSGKLKESVKCSHQRDEI---EK---TEIIHVPD---STKNLVLSEEK-DLSTA---
RSTE-STSISVVPETE--------CGTQGSISLLEDIA---------L-RKAKTASK-QC
MSQFVAIEKPKQPFPDASE-----DAGHSTEGLK---HPPRHQLSHI-QEANIEMEESEV
DTQFLQNTFHTSKRQSFALFSNPRNPEEYTAA-SVHSTSLKKQSPEVTLECEH-KEESKI
RQD---------------LPAVCQ--KDE-TGGDAK--STGGSGLCQSF-QSR-GSETAL
RIAGKSGMPQSPSLKQSISPIRSPA-KSRWK-----------KPLSEERSDRHSWSPEKA
VGNEMIV-----QNSN-AMQNNS-RENAYKEAGSG--------------SINEV------
-----GKLHRNRGPKLSTVFRLSFVQSETCKQSLVSG-YN--LEI-------SQE--GNE
VVQAGSADFSPCLISD-KLEQPVR-SDNVSQVCSETPENLL-DNDETKES--TNFAKGDI
METS---------IVFGTSKHR---RELSRSPSPFAHM--PLAQSH-QSRARKFESSG--
ESISGEDENLPCFQHLH-G---------------------------KVTSTLSQST----
K---HYLSHEAENQVSLK--NGSD-DCSSEVIL-VEASQEHHFSEEAKCSGSMFSSQRSS
LEDLAENTSSQDSCVMFNP-PSQQVELRSASQEVVS--DEEVVSD-DEEKETDLEA---D
NHQEDYV--P-SSLEASVYDSETNLSDDCS----VLDILTTQQRDTMKDNLIKLQQEMAQ
LEAVLEQHGNQASGRSPSLLV-DSYV--PEDLPSPQQNRSGPD-----------------
----VCTSKKSDEYPVSQNPK--------SFSPDKFLP---LPPDSSTSQNKEPTVERSS
PFRSQLL-SNRSSAHSHSGSIQNRNCPSGEELVKAVEAQE----LRE-------PHLPW-
QEPEG-TPYLESGISLFSN----------REHS-DRALEPAHVC----------TSPASA
LK------TSQF--QAVAFSKS-PP--APHAAN-V---------------AVEENMSREQ
---------PERVNKRISMVVS

PF00533 // ENSGT00440000034289_0_Domain_3 (2003, 2070)

GLTAKEFMLVQKFVRKHHLTLTGKVTEETTHVVMKTDA
QLVCERTLKYFLGIAGGKWVVSYSWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKEKKILDEHDFEVRGDIINGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

-EKIFKGLQVCCYEPFT---NMPKDQLEWMLQLCGAIVVKELSSFTVS----
CAHPIVVVQPEAWT-------E-ENDCQAIKQLY----EASVVARDWVLDSVALNQCQDL
ENYLIAHISKASS-PQG-------------------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVPLSNLGIVRT-LRTKQQIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DAED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IKDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNAIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTERN-KC
MSQCAAFENPKELIHGGSE----DT-RNDTEGFK---YPLGSEVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFSVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSPERA
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
LVQTVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSIQR---GELSRSPSPFTHT--HLAQGYRK-EAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKALVSD-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEKDSHIRGQRNNSMFSKRPR
EHISVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGPHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREN
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-----------------------------------------------TSPWGYTISKIQN
L

PF00097 // ENSGT00440000034289_0_Domain_0 (62, 105)

IKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVPLSNLGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
EIN-IKDKIFGKTY-RRKANRPNLSHVTEN-LIIGALVTESE-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLQVST---------L-GKAKTELN-KC
MSQCAAFENSKELIHGCSE----DT-RNDTEDSK---YPLGREVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFSVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSPERA
VGNENII-----PSTVSTISHNNIRENAFKEASWSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
LVQTVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRK-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LSKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSA-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEKDSHIRGQRNNSMFSKRPR
EHISVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGPHNLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREK
--PKLTAS-TERVNERMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2111)

IKERKMLNEVNFLLSIPL-----------CL
SL-----PLF

PF00533 // ENSGT00440000034289_0_Domain_5 (2111, 2211)

QIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

----------------------------------------------------------

PF00097 // ENSGT00440000034289_0_Domain_0 (59, 105)

LE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-RKGPSQCPLCKNAITKRSLQESTRF
SQLVEELLKIIHAFELD--T-MQFANNYNFSKK-EN-NPPELLKE-EVSIIQSMGYRNRA
KRLRQSEPDNP--SXXXXX-XXXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXX---XVRDQELLQITPQEARVEVSLD-A--VKKAACEFPEKDLTNIEHHQSSKK
D-------------LNTIEKHATERH--PEKYQ----GISVSNLHVEPCGTYTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQQNRWAESKEMCNDRQ-TPSTEEKVD-
-----VDADPLYGRKELNKQKPPCFESPQ-NTQD-IPWITLNSSIQKVNEWFSRSDDILT
SDDSHNGGSESNAEVVGALKV--PNEVDGYSGSSEKIDLEFHHI-GASVFAGERVQSKPT
-ETNIEDKIFGKTY-HRKASLPNLSHIAEN-LFIGAIATEPK-ITQ---ECLLT-KKIKH
KRRT--TSGLHPEDFIKKVDLTVVQKMPEKINQGTDQMEQ---KNSQVINIANSGHENET
KDDYVQKEKN---ANPTESLEKESAFRTNGEPISSSISNMELELSIYNS---KASKK-NR
LKRMSSTRHIH---ALELVANR-----NPSQPNHNELQIDSCSSSEEIKKK-NSDQKPIR
HSRMLQLLKDKETP--TGTKKSNKR---NISK--RHSSDAFPELNLTNVTGFLTKCSSSD
KLQE------FVNSSLQGE-V---AEN--LETIQVSDSTRDAGGLMLSGGK-GLQTE---
RSLE-STSISMIPDTD--------YDTQDSISLLGADT---------L-GKAKAAPN-QH
VSQYAAIGNATELFHGCSK-----DTRNDTENFK---DPLRREANHT-QETIVEMEEGEL
DTQYLQNTFKISKRQSFALFSN---PEKECATVSADSRRLRKQSPKVTFDCRQ-KE-DQE
KKESKIKHVHAV-HTTAGFPVVCQ--DKPV---DAKCSI--GVSLCQSF-QXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-----------XXXXXXXXXXXX--XXXX
XXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSNGGIRTSGEN
IQ---AELGKNRGPKLSAMLRLGLMQPEVYEQSLSITNCK-HPEI-------KKQGENEE
VVQAVKTDFSPCLISD-NLELPMG-SSHASQICSETPDDLL-DDDEIKEN--NSFAESGI
KERS---------AVFSKSVQR---REFRRSPSPLAQT--SLTLGH-QRRARKLDSSE--
EDVSSEDEELPCFQHLLFG---------------------------KVTNMSSQSTRHGT
VATECLSKITEEKLVSLK--NSIN-DCSNQVSL-RKASQEHHLNEEARCSSSLFSSQCSA
LEDLTANPSTQDPFLMFDPPSEQVRHHFENQEVVLS--DKEELVSDDQERETGLEE---D
NHQEDQSVDSNLGEAASGYESETSLSEDFSGLSSQSDILTTQQRDTIQDNLIKLQQEMAE
LEAVLEQHGSQPSNSSPSLIA-GSCV--PEDLLNLEQNTTEKXX----------------
X---XXXXXXXXXXXXXXXXX--------XXXXXXXXX-----XXXXXXXXXXXXXXXX-
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXG-TPYLESGISLFSD-------DPESDPSEDKAPNLAHVC----------SMPSST
SALK----LPHF--QVAESVKS-LA--VAHTTN-IAGYN-----------VREEXXXXXX
--XXXXXX-XXXXXXXXXXXXXXXXXXXX

PF00533 // ENSGT00440000034289_0_Domain_3 (2010, 2070)

MLVHKFARKHHSTLTNLITEETTHVIMKTDV
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKMLDEHDFEVKGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2182)

QDRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKEPSSFTLST---
GTHPIVVVQPDAWT-------ED-SGFH--------------------------------
------------------------------------------

-------------------------------MDLAVVAAGEVQNVLLAMQKNLE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLD
VVKEPVSTKCDHIFCRFCMYKL---------LSKKKKGVVQCPLCKTEVTKRSLTENSRF
KQLIEGLLEAIHAFELD--TGVKFLNSHRLPKSSTEATAAKLPCN-ESSVIQSKGFRNRK
RSAKENEQENC--SLQGAN-VDAQRADISVKRCSLRNRNQKHDLEKGVFIELGTDSSEEL
CKQAGNT---GLGNKEVVQISSEEKLEEPKSPEK--GNEYSCNTRPTELRAKEIILPNVI
V-------------IKMVERKAWNHY--IVRQN----TKALSDLPTERCDRANNASPL--
KDGDTSLSKNAEETGAEQTQCSNKSQEFDLEDSSENRPGKSKEIDAVVQ-SVEDVEMCES
E-NNSEKESPL--EKLLQPETPHCPTLHQ------VSRKRLKRSIQKVNEWFSKSDEILS
SNSSHDDPAEASDVSGEGDAL-----SDKDSCISEKTSPVVGFM-ETTVSEGNKRWSKEK
-TDNIKDKIFGKTY-ERERKSNPPIIMRE---ILPTTKKEDVPAVQECLNNSRK-DSLKR
KRKP--VRHLQPEDFIKKKDVEEAGGCPQNVNSCLGDAEK-KKCEESS-AVKENPPPEKR
RGSTLA------------EFEEGASMSKNATEKVTCEHSGELELNNSDQKSTKNPSS-AA
KRCRRSTRTMC---ALQLVVDK-----NSASPDPAETLIESYPSSEEPRNA-DSEQRQVR
RSRRLQLLSEEMTK--ETAKRAVIKEASKYDG--DQEGPVFGVEKTVLVR--DSECKDLC
EQQD------ISSCKPLTNLE---SADLEANAIQMSP--KNSSETAKTGKR-LFNPA---
PSHQHSDLNSSSPRA----------GSEEG-EVLGDPFLHQSPSKTVV-QTASHLPEGKR
AESCPTLPQDKE-----------HSTQNVPEGLRTEKSPMAKN----VSELAKESEDSEQ
DTQYLRNIFRNSKRLSFSLYPAP---RKACEIDDVASE-------KLKMSCAD-QKEK--
--------------TAENLSNVCE--KEKMKNCESACASPVSCTVSNAE-CVRSG-----
---DCQDVSQVANQGNLMTPVRMGAASSEGKNRPRKGEQGSEKPQKGERGSEKTAS--TD
AGAESVLRQNPVKSSKSQSVQSNTEEHVFQRTDLN--------------TVSETCFSSES
DQAEKAEFVDSEGPVLC-FQPGSMARPTACQQRSAEFNCKDAEKRR--SKRRRLIGDEEP
ATQTASTGVPECLVAE-TLEETFK-GGC--SDTSETPDGLMCSDDDSEEN--VSFCEAPR
KDSS---------AVFVKSDLVKERDHGGVGSQPR----STGIQRA-RRRAQKLQSSS--
E-ESSEDEDLPCFQALIFG---------------------------KSASTPLQTNKQVT
SALGS---SGNPNTLPRG--GSRE-DKVQKTPEAALSNGCASPSQESECSVNLFSSQSNV
SEESADGAQEPKKPLLQVHASKQQSNVSESKETLQS--CAGRL-----KRR----K---T
NSKDECQEDPNLG-EASGYDSETSHVEDSCGPFSQGEILSTQQKNAMQNNLKKLQQEMAA
LEAVLQEHGSQDSEPLPACRELLGPR--SERTLAVEQTRQREKG----------------
A---ESTSEGSLENHKCSTSK--------GFSADEVHV---IPSDSSNSEVKELEIERSP
ELPYPSL-KSSWSKRPDLEEDLRHD----------SVVENKAPQETKPVHEAVQEYNVT-
SCLAG-LVWQSNCLNVENA-------DEKSGTKLNKASVLNDLCGNV-----TRSPHASS
SFVK----PPHL--QTAEATNS-SA--VVQNDN-KSSSQ-----------GSVLHNAYGK
--ENATNP

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-VVTNRKKMSIVASGLKQSEHMVVQKFARKTQSTFSNHITDGTTHVIMKTDK
ELVCERTLKYFLGIAGRKWVVSYQWVVQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

FKEGMILDEENFEVRGDVINGRNHQGPKRAR
QS-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

LTEKIFKDFEICCYGPFT---DMTTGHLEWMVELCGASVVKQLHLFTHKT---
NSTAVVVVQPDAWM-------EG-TSYKAIQQKN----NVAVVTREWVLDSVACYECQEL
DAYLV-------------------------------------

-------------------------------MDFSVAHIEEVQNVLNAMQKI

PF02891 // ENSGT00440000034289_0_Domain_0 (53, 108)

LECPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNHITKRSLQESTRF
SQLVEELLKIIRAFELD--TGLQFANSYNFAKK-EN-NSPEHVKE-EVSIIQSMGYRNRA
KRLRQSEPENP--TLQETS-LNAQLSNFGIVRS-LRTKQHTQLQNKSVYIELGSDSSEDT
VNKESYY---SVVDQELLHIAPQGAKAEASLD-P--TKKAACEFSEKDITNLEYRQSSNK
D-------------LNTIKKHAAEKH--PEKYR----GISVSNLNVEPCGTNTHASSL--
QHKNSSLLLTKDRMNVEKAEFCNKSKQPGLARSQQSRWAESKETCNDRQ-TPSTEKKVD-
-----VNADPLYERKEVNKQKPPRSENLR-DTQD-IPWITLNSSIQKVNEWFFRSDGLDV
LND---EGPESSAEVAGALEV--PNE--VHSNSSEKIDLMASDLHGALICESERVPSKPA
-ESNIEDKIFGKTY-RRKAGMSHLSHITED-LIMGAIASEPQ-IAR---EHPFT-NKLKR
KRRT---SGLHPEDFIKKVDLAVVQKIPEKINQETDHVEQ----NGQVMNIANGGRENET
KGDYVQKEKN---AIPTESLAKESAFRTKAEPISSSISNMELELNMHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVNR-----NPSPPTHTELQIDSWSSSEETKKK-SSEQKPIR
HNRNLQLMKNQETA--TGAKKSNKPK-EQISK--RHGADSYPELHLTTTAGFITKCSSSD
NLQE------FVNPSLQGEKT---EEN--LETIQVSNITKEPKDLVLNGGR-DLQTK---
KSIE-STNISVIPDTV--------YGTQDSVSLLGADT---------P-GKAKTAPN-RC
ASQCTAIENPSELTNSCPK-----DTRNDTEGFK---DLLRCEASHI-QETCIEIEESEL
DTQYLQSTFKVSKRQSFALFSNP---EKKCATICAHSKSLRKQSPKVTLVCGE-KEENQG
NREPKIKHEQAV-HMPTGYPEACQ--KE-KPSDYTKYSIKGVSGLCQSS-QFR-GSESEL
ITADGHGISQNPDQIPSLSPTRSSV-KTKCK-----------TNLLEERFEEHTISLERA
MRNENVI-----QSTVSTVSQNNIRESASKEASSSSINEV-------CSSINEVGSSGEN
IQ---AEISRKRGPKLNAVLRLGLMQPEVYKQSLPISDCK-HPGI-------KTQGENEG
VVQAVNTDFSPCLISD-NLEQPVG-TSRASQVCSETPDDLL-DDDEIKEN--ISFAENGI
KERS----------VFIKDDQR---REFRRNPSPLSH--SGLAQGC-LRGARELEPSQ--
ENISSEDEELPCFQHLLFG---------------------------EVTNIPSQSTRHNA
DAIQCLSKNTEENLGSVQ--NSIN-DCSNQVTS-AKASQERHLSEEVRCSSSLFSSQCSV
MEDLATNTNTQDPFLMFGSPSKQARHQSENQEVVLS--DEELVSD-EYKRGPGLEE---D
NHQDDQSVDSNLDEVASGYESESSLSEAGSGPSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQQGSQPSNSSPSLLA-GSRA--PKNLLNPEQNTSEKG-----------------
S---ISTSEKSNEHPVSENPE--------GLSADKFRP---SLDS-ATSKNKDPGMERSS
PSKFQLLDNNRWDVHSHSRSLQNGNRLSQEELVKIVDVEEQQVEKSEARGLIEQPYLPL-
QDLEG-TPCLESGVSLFSD-------DPESDPSEDRAPDPAHVC----------SSPASS
SALK----LPQF--QVAESASD-SA--DAHTNN-TTAYN-----------AREESVNKET
--PGVTSS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-AERANRRASMVASGLTQKEFMLVHKFARKHHCTLTNQITEETTHVIMKTDA
DFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKMLDECDFEVRGDVVNGRNHQGPKRAR
EF-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFKGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKEPLSFTLGT---
GTHPIVVVQPDAWT-------ED-SGFHAIGQLC----EAPVVTREWVLDSVALYQRQEL
DTYLIPQIPHSHY-----------------------------

----------------------------------------------------------

PF00097 // ENSGT00440000034289_0_Domain_0 (59, 105)

LE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKEPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIQAFELD--TGLQFANSYNFLEK-EN-NATEHLKE-EVSIIQSMGYRNRG
KKLRQTETDNP--TPHESS-LSVKLSNPGIVRS-LKTKQQLQSHKKSVYIELGSDSSEDS
FNKASYC---SLGDDGLLQIISHEANIETSVN-S--AKNAACEFSE-DITDIEQHQPSNK
D-------------LTTTEKHATEKD--TEKYQ----SISVSSLHVEPCGTDNRASSL--
QPENSSLLLTEDRMYVEKAECCHKSKQPSLAKSQQNRWTESKEKY-DRQ-TSSAEKKVD-
-----LSADPLSGRKQPNKQELPCSGSSR-DSQE-MTWITQNSSIQKVNDWFSRSDDVLS
SDDFHDAGLESNTEVAEIIEI--SSTADEFSGSSEQIDLTASES--------RRTLSKPV
-ESNIEDKIFGKTY-RRKTSFPNLNRITED-VILGSSILEPH-IAP---EQPFT-NKLKR
KRSM--TSSLCPEDFIKKGDLAVVQKTPEKVIEKSDQTDQ----NGQVMNITTNGE-SET
KIDYAQKGKN---TNPTESSEKESAFRHKGECISSSISNMELELNIHSS---KTSKK-NR
LRRKSSSRHIH---ALELVVSK-----NPSPHNHMELQIDSCSSGEEVKEK-NFDQIPVR
HSKKPQLTENKELS--TGTINSNEQN-EQINT--RISGDIFSELNLV------NDCSRAN
KLQE------FVNPSPQKE-L---EEN--IGTIQESN---HPKDLRLSRGK-GLQIE---
RYVE-NTGISLAPDTD--------YGSQDSISLLDTDT---------L-EKPKTVLD---
----QQIENPKKLTRGCTK-----DCRNDTEDSK---GQLKYEDNHTV---EASVEESEL
DTQYLHNTFKASNRHSFSLLSNPGNSGRECSTVFAHSGSLRKQSPKGTMGCEQ-KEESCG
PEESKIKHLQPI-HTTLSFPGTCP--KSS-PGDYAKCSIKGVSRFCNSS-EFR-GSEAEL
THLNL---NLQNPQVPSFSPNRSSV-KTLCK-----------KNLPEEMFEDCSPSSEKA
MGNGSII-----QNTVSTISQNNR-ENACKEVSSSTINEVGFSTNEIGSSVNEIGSSGEN
VK---AELGGNRGHKLNTILRSVLMQPEVNNLSLPVGSCT-HPEI-------KRQLENEG
VVQAVTTDFSPCLVSD-NPEDLMG-SNA--SSCSETPDDLV-NDDEIKE---ISFAESDI
KEQS---------AVFGKSVQK---REFKRRPNPLDDT--DLAQTH-RRQSRKLESSE--
EDMTSEDEELPCFQHLLFG---------------------------NAANKP-QSSRDNS
AVSENSSKKTEENLESLK--NNLS-DGSNQVTS--KAFQEYHHSKEPKFSSSLFSSQHSA
LEDLTANTNTSDPFLIGS--SLQMRYHSKNQ-EV-L--NDEFISD-DEEMETGLEE---D
NQEE---QDSNLGKAVSGYVSETSFSEDSSELSSQSAILTTQQKDTMQDNLIKLRKEMAQ
LEAVLEQHGNQPSRCS-SPIA-DPYA--PEDLLNPEQNTSDKXX----------------
X---XXXXXXXXXXXXXXXXX--------XXXXXXXXX-----XXXXXXXXXXXXXXXX-
XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXG-TLYLKSVISLFSD-------DPESDPSEAGIPVPAHVG-----------LPAST
SALK----SPHC--QVAQSAKT-LT--DAHTIN-TAGYH-----------LKEETKGRKN
--PEVVSS-TE---NKISMVASGLTPEEFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXX
XXXXXXX

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

XXXXIFRDLEICCYGPFT---NMPTDQLEWMLRLCGASVVKELSSFTRSK---
GRHPVVVVQPDAWT-------ED-SGFHAIGQLC----EAPVVIREWVLDSVVLCQCQQL
DNYLVPQIPSCC------------------------------

---------------------------------LSVIAIGDVQNVLSAMQKNLE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPVCLD
VIKEPVSTKCDHIFCRFCMFKL---------LSKKKKGVIQCPLCKTEVTKRSLKENSRF
KQLIEGLLEAISAFELD--TGVKFLSS-HFPKTSTEAATAELLDN-NSSVIQSKGFRNRK
RSAKENGQDSY--TLGEAN-VDPELTGNRVEGCYLRNKKQKRGIEKGVLIELGTDSSEEL
FILASDT---GLEDKEELEE--------PKSA-E--KYESLKE-----------------
----KPQEALSKKSMLNITEHVKSNQVNTVEGQSSPSNVFDADLLTEQCNEISNASPL--
KNNYTSFSNNAEEMDAEESLCSTKNQELDFEDGSESRLNKIKEKDICVL-SVEDVEMYE-
-----PVNDSLLEKEP-PVEKP-QPKIPHCPTLHEVSRKRLKQSIQKVNEWFSKSNEILS
SSSFQNDPSEATDASGEE----DVSLSDKDSCISEKTNPIVDSVEFA-VFERNKRWPKQT
-TYSIKDKIFGKTY-ERGRKSNPSTILRD---ILPATKK-DVAAEEKCLNNSRE-DGLKR
KRKP--ARVLQPEDFMEKKDLEEADRCPQGINSSLGDAEK-RKCDENSAV-KENSLLEKR
KVSTLTEF----------EEG-ELQWKNAIEKVSGKP-FGQLELSNSDQKSTKNACS-AA
KGCRRSTRTRC---AIHLGDNR-----NPDSFDPAEPLIDSYPSSEEPNKV-DCEQRQVR
RSRRLQLLSKEITK--ETGEMRITKEARNSDS--GPEGSVFGVER--NVLVHDSQCKDLK
-QQD------ILSYTSLTDRN---GADLEANGMQIS--SKNSADM-VKNTS-LFNPT---
FSCEHSNFNSPSLKA----------GSQ-------------SPSKTVL-DTASILTEEKR
SGSCTAFPQDKG-----------CCSQNVPEDFRIEKSPITKNV----SELTVEAEDSEL
DTQHLRNIFRSSKRQSFSLYPAP---MKTCTTDDVESG-------KLNTLCPD-QVEKRC
SKYFMTENLQEKKTTAENLSSVCE----KFKTCESACV-------SPVS-CFVSSAECVH
AAEHQEDILKVANHGNI-------------------------------------------
-----------VRSNRNLSDQSNTEERAFQRTDLN--------------TVSETYFSSES
NQVENAEIVDGKEPMQH-FQPSPMVCPTVHQQNPAEFNCEVTGKKVAKK----REGNEER
VIQTVNTGLSEYLVRE-VLEESLK-GRSDFTDLSETPDGLLCSDNDTEDS--TSFYVTNR
KDTS---------AVFVKRSGAVLMKEVNDSVVSCKPR-SEGIQRS-RRRAQKLQSSD--
-EESSEDEDLPCFQELMFG---------------------------KSVSTPLQIKKQVT
SVVRSS---ANPSMLPCS--ECLNENNEQKTLEAALSNECVSPSQESECSVNLFSSQSNI
SEESVDGAHEMRKTLTQVS------NINKSKEALHS--SSGGLKRR--------KNNSYD
EYQEDPNMGANLGEA-SGYDSETSRVEDSHEPFSQGEILSTQQKNAMQNNLKKLQQEMAV
LEAVLKQHGSQDTEVLPLCRELPYAS--SGGTLGMEQMRQEMAE----------------
NNHSVINTERLFIE------Q--------ILKCDIAKS-----TTNKMLENEFNKLMIS-
----------NDYFTSVSHKLRAPS-------------------SCQI---NVLLLLVN-
ADMMTISEMLNNKQVYFPSPL-ENVSEHDSETKLSKASVLPVLCGNV-----TRNPNSSS
SSVK----HPCP--QTAEATNN-SA--VAQSDN-KSNVQVCESKRN---------NAAGK
--ENVASS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-GTTYRTEMSIVASGLNQSEHLMVQKFARKTQSTFSNHITDGTTHVIMKTDE
ELVCERTLKYFLGIAGRKWVVSYQWIIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

FKEGRILDEENFEVKGDVINGRNHQGPKRAR
QS-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

LAEKIFKDFEICCYGPFT---DMTTGHLEWIVELCGASVVKQLHLFTHKV---
NSTAVVVVQPDAWM-------EG-TSYEAIQQKN----NVAVVTREWVLDSVACFECQGL
DAYLV-------------------------------------

-------------------------------MDL--CAVEEVQNVLRTMKKILELNFCGY
--------------------VS---------NFC-KRGPSQCPLCKNEITKRSLQESTRF
SQLVEELLKITHAFELD--TGLQFANSYSFLKK-EN-KSSEHSHE-ESSVIECVGYRNRT
KRLRQNEPGNP--TLE-DS-FSDQLSNLGIVRP-LKKNQQIRPQNKSVYIELGKFL----
ISVFFPF---SVRDQELLEITPQRSKAE-----A--AEKADCEFSE-DVANIEHHQSSNR
D-------------LNTIGSHSVEKH--SEKYQ----GTSTSNLHEEPCGTDIHASLL--
QHENGSLLLTEDRMDVEMAELCSKSKQSGLAGSQQSRWAGSKKTCHDRQ-SHSTEKKAD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 604)

DPLDEREKWNKQKAPSSESLS-DTQD-TPCVTLNSSIRKVNEWFSKSGKMFT
SYGTSD-RHEASAEGAGTFEV--SNEVEACSGSSEKIDLLASDPHNASVCRSETVCSKPV
-ERNIKDKIFGKTY-QRKGSLPNLNHVTE---ILRAFASEPQ-ITQ---EHPFT-NKLKR
RRRT--ASCLHPEDFIKKADLTVVQKTSENINQGADQMEQ----NGQVLNITNGGHENKI
NDDNVQKEKN---PNPVESLEKESAFRTKAEPISNSISSLELELNVHNS---KAPKK-NR
LRRKSSNRHIL---ALEL-VSG-----NPSPPTHTILQIDSCSSSEETKGN-NSNQMPVR
HGKKHQLLEDAEPA--AGSKESDEPD-ERVSR--RGAGDVFSALKLTNTPGLLTNCSSSN
KPQE------FVSPHPQRKAI---EK---LE------TSKELKDPMLSEER-G-WSE---
RSPE-STSTSLVPDTD--------HGSQNSVSLLEPNT---------L-RNAN-----QG
MAQYIACEKPKEPIYDSK------DTGNCTEGFK---HPLGLELNHI-QETSIDTEESEL
DTQYLQNICQVSKRQSFALVSNPRNPEKESTTACAHSVFLRKLSPKPSLVREQ-KEKNQG
WEESKISHIQAF-NTTGDFAVVCQ--DDT-PGNDAKC--TGVSRLCPSF-QFR-GRECEL
ISADKPGISQNLHLKQSLSSIRSSV-KTDHR-----------KTLLEERFVEHSLPTEKA
MDNEISI-----QSPVHTISQDS-RENPCKEGSS--------------DSVNEVGPSDED
FQ---EQLDRNRGPRLSTVLRRSLMQPEAYKQSFPISDCK-HPEI-------KKQE----
-AQASSANISPCLFSE-QLEQTMR-SGSVSQVCSETPDDLF-DVDEIEEN--TSFGEGDI
MERS---------AVFTKSILR---REVSRSPVLLTHT--SLARSH-QKRSRKLESS---
---SSEDEDLPCFQHLL-G---------------------------KVTSTS-QITKHSP
AVTQRLSEKTE-NQEPLK--NSIN-DCNSEMSL-AEGSQEHHLSEDGKYSASMFSSQHSE
LEDVASNTNSQDLLF---NSSKQMSHPSENQEVVLS--DKELISD-DEEMESSLEK---D
NQEENEIS----DLAASAYEGEANLSEDSS----QSDILTSQQRATMKVNLIKIQQEMAQ
LEAVLERQENLPSCCSTSLLA-DPCV--PKDLLNPEQNVSK--T----------------
A---VLTSKKSNKTRVSQNTK--------NVSADKFHP---LPAGSSTSKNKGSEVERLK
KKKSICG-SP--------GTGVMDDCLQ----------------SCG--YWVELWMTVC-
NHVEV-IPYLESGVTLFSR------SHPESELSKEKAPEPAHV---------------SI
SALK----ISQC--QAAEYSKS-PA--AAHSTD-TEVAK---------------TVSKTK
--SKWT-S-SKGRDKKIS

PF00533 // ENSGT00440000034289_0_Domain_3 (1999, 2070)

MVVSGLTHKEIMIVQKFAEKYHVTLSDVITEETTHVIIKTDA
EFVCERTLKYFMGIARGKWIVSYLWVIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKKRKLLNEVEFEVRGDVVNGRNHQGPRRSR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

-EKIFRGLEICCCEPFS---SMPRDQLERILQMCGASVVKELSSLTFGT---
VS---------VWG-------PSYRESNILSQMC----EAPVVMWDWVLDSISLYQRQNL
ETYLISACPKDD------------------------------

-------------------------------MDLSVDHIEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANNYNFSKKTEN-NSPEHLKE-EVSIIQSMGYRNRA
KRLRQSDPEDP--TLQETS-LSAQLSNLGIVKP-LRTQQQIQPQNKSVYIELGSDSSEDT
VNKANYC---SGGDHGLLETTPQGAKAE--------AKKDACQFSEKDITNTEHHHSSNK
D-------------LTATEKHATEKH--PEKYE----GISVSNLHVEPCGTDTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPVLAKSQQSRWAESKGTCNDRQ-TPNTEKKVV-
-----LNT

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DLLYGRNELNKQKPACSDSPR-DSQD-VPWITLNSSIQKVNEWFSRSDEMLT
SDDSQDRRSESNTGVAGAAEV--PNEADGHLGSSEKIDLMASDPHGALIRERERGHSKPA
-ESNIEDKIFGKTY-RRKASLPNLSHVIED-LILGASAVEPQ-ITQ---ERPLT-NKLKR
KRRG--TSGLDPEDFIKRADSAVVPKTPEKTIEGTDETEQ----NGQGMNITSKGHENET
KSGNVQKEKN---VNPTASLGKEPAFRARAEPISSSISNMELELNIHGS---KAP-K-NR
LRRKSSTRQIH---ALELVVNR-----NPSPPSHTELQIDSCSSSEEMKKR-NSDQVPVR
HSKKLHLRGDKEPT--TGAKKNNRPH-EQVNK--RPISDAFPELNLTNVPVSITNCSNSN
KLQE------SVSPNLQRE------EN--LGTIQVSNSNKDPKDVMLSGGK-GFQIE---
RSVE-NTSISLVPDTD--------YGTQDSISLLETDT---------L-GKAKTTPN-QH
VRLCAATENPKELSLGCSK-----GVRNDTGDFK---DPLAHDVNHT-QEASIEVEENEL
DTQYLQSMFKVSKRQTFALFSNPANPEKECTTVHAHSKSLREQSPKVTHEGGQ-KDENQG
KSESKVKHGQSV-HTTVDFLVVGQ--KDKKPSDFAKCGAKGVTGLYQTS-QFR-GHKTEF
INANKPGISQNPYVIPSLSPIRSSV-KTICK-----------KNLSEEKFEEPKMSPERT
MGNESII-----PNTESTVSQNNIQERTFKEGSSGSPNEVGSSTNEVGSSINEVGSSGEN
VR---AEPGRNRGPKLSAMLRLGLMQPEVYKQSLPVSNCN-HTEI-------KRQGENEG
IFQAVNADFSPYLISD-NPEQPMG-SSHASQICSETPDDLL-NDDKIKEN--LNFAESDV
KERS---------AVFSKSAQE---GEFKRSPSPLAHR--RLAQGH-QRWARKLESSE--
ESGSSEDEELPCFQHLLFG---------------------------KVTNTPSPSTRHNA
VAAEGLSKEAGESLVSLK--NSLN-DCSDQVTS-AKASQEHHLSEDVRCSGSLFSSQCSA
LEDSAANTNSQDPFLMFDPPSKQVEHQSENQ-EVLS--DKELVSE-DDERETGLEE---D
NCQEEQIVDSDLGETAFEYESETSFSEDCSGLSSQSAILTTQQRDTMQDNLLKLQQEMAE
LEAVLEQHGSQPSHSSPSLIA-DSCA--PEDLLNPEQNTSE--K----------------
A---VLTSEKSSDYPITQNPE--------SLSADKFQV----SLDRSTSKNKESGMERSS
TSKSQLS-DSRWYMHSPSRSLQNRSCPSQEELIPVIDLEEQQLTTSEAQDSVKQSYLPR-
QDLEG-TPYLKSGISLFSD-------DPESDPSENRAPESAHVF----------STPLST
SALK----LPQF--QVKESAKS-PA--AAHTTN-TAGYN-----------VRQESMSRKK
--PEVISS-TKTNSRRISIVA

PF00533 // ENSGT00440000034289_0_Domain_3 (2002, 2070)

SGLTPKEYTLVQKFARKHYITLTNLITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKEGKMLDEHDFEVRGDVVNGRNHRGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFKGLEICCCGPFT---NMPTDQLEWMVLLCGASVVKDPSSFTFRQ---
GTRPVVVVQPDAWP-------ED-SGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQVPQSCCRPCT-------------------------

-------------------------------MDLSALRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLEYANSYNFAKK-EN-NSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVQLSNLGTVRT-LRTKQRIQPQKTSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDEISLD-SAK--KAACEFSETDVTNTEHHQPSNN
D-------------LNTTEKRAAERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRR-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLCERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLG
SDDSHDGESESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV
ESN-IEDKIFGKTY-RKKASLPNLSHVTEN-LIIGAFVTEPQ-IIQ---ERPLT-NKLKR
KRRP--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQTEQ----NGQVMNITNSGHENKT
KGDSIQNEKN---PNPIESLEKESAFKTKAEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKKYNQMPVR
HSRNLQLMEGKEPA--TGAKKSNKPN-EQTSK--RHDSDTFPELKLTNAPGSFTKCSNTS
ELKE------FVNPSLPREEK---EEK--LETVKVSNNAEDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKGLIHGCSK----DN-RNDTEGFK---YPLGHEVNHS-RETSIEMEESEL
DAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQ-KEENQG
KNESNIKPVQTV-NITAGFPVVGQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYRIPPLFPIKS-FVKTKCK-----K------NLLEENFEEHSMSPERE
MGNEN-I-----PSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDEN
IQAE---LGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCK-HPEIKK----QEY----EE
VVQTVNTDFSPYLISD-NLEQPMG-SSHASQVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQK---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVNNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DCSNQVI-LAKASQEHHLSEETKCSASLFSSQCSE
LEDLTANTNTQDPFLIG--SSKQMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---N
-NQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIS-DSSA--LEDLRNPEQSTSEKDSHIHGQRNNSMFSKRPR
EHISVLTSQKSSEYPISQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCPSL-DDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESARVG----------NIPSST
SALK----VPQL--KVAESAQS-PA--AAHTTD-TAGYN-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGLTPE

PF00533 // ENSGT00440000034289_0_Domain_3 (2008, 2070)

EFMLVYKFARKHHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLSGVRVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKMIQAFELD--TGLPFANSYDFSKK-KN-NSPEHQKE-DVSIIQSIGYRNRA
KGLRKIEPKNP--TLE-TS-LSVQVSDLGIVRS-LRTTHQIQPQNKSVYIELGSDSSEET
VNKANYY---SLGNEEFLQSTLQGANAEATLD-P--AKKAACVFSEKEITNIEPHQSNNK
D-------------LTTVKKHATERH--PEKYQ----GISISNLHVEPCGTDTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQQSRWAESKETCNDRQ-TPSTEKKVV-
-----PNVDCLYGRKQQDKQKPSCPETSG-DNQD-VSWITVNSSIQKVNEWFSRSNEMLT
PDDSLDRRSESNAKVTGALEV--PKEIDGYSGSTEKIDLLASESHNALICENKRVHSKPV
-ENNIKDKIFGKTY-HRKTSLPNLSHITED-LTIGAFAAEPL-VP-----CPPA-NKLKR
KRRT--SSGLQPEDFIKKVDLAVVPKTPAQINQGTDQTVD----NDQEMNITNRGNENET
KGDYVQKETN---ANPTESLEKESSFRTKVEPISSSISNMELELNVHNS---KKPKK-NR
LRKKSSTRRVH---ALELVVNK-----KPSPPNHTELQIDSCTSSEEM---

PF04873 // ENSGT00440000034289_0_Domain_2 (772, 1153)

-NFDQIPVS
HSRQVQVIEDTEPP--TGARK-NKPN-EQISK--RHASDVFPEVKLTSIPGVFTNCSSSN
KLQE------SVNPSLQRREI---EEN--LDTVQVPNSALDPKDLLLCGER-GLQTE---
RSVE-STSISLVPDTE--------YGTQDSISLLGANT---------L-GKAKTAAN-GH
VSESTAIGNPKELIRDCLK-----DTGNDPDKCK---DPLRSEV--D-QETSVAMEESEF
DTQYLQNTFMGSKRRSFALCSKPGDPEKECAAVCTRSNSSRKQSPEVTLEREQ-KEESQR
KEEWKISHVQAA-DSTVGFPVVCQ--KEK-AGDCAKWGIKEISRLCLSS-QSK-GSETEL
IAVSKHGMSQNP

ENSGT00440000034289_0_Linker_2_3 (1153, 1993)

YHMPPISPIKPSV-KATRQ-----------VNLSGQRSEEHSVSSERA
VGSESLI-----PSTVSTISQEYIRESALKGFSSSSINEGGSSANEVCSSVNEVGSSGEN
MQ---AQPGRSRAPELNAVLRLGLMQPEVCEQSLPVSNSE-LPKL-------QRQEENKG
VVQAVNRDFSSYLVPD-SQEQSIG-GRHASQICSETPDDLL-DIYEIKEN--TSFAESGI
KERS---------AVFSKSVPR---GECSRTPSPSGHA--CLAQSH-QREARKLESSE--
EHIPSEDEELICFQQLLFG---------------------------KVTDRPSQSTRRSA
VATECVSEKTEENFVSLK--NSLN-DSDNEVTL-SKASQEHPPSQGSECSGSLFSSQCSA
VEDLNENTNSQDPFLMFDSPSKQMRHQSESQQ-DTS--DKELASD-D--------E---D
N-LQGQNVDANLGAAASGCESEASLSGVHSGLSSQSEILTTQQRDTMQDNLLKLQEEMAQ
LEAVLEQNGSQPSYRPPSPLP-DPCA--SEDPLNLQQNTPE--K----------------
G---VLTSEKSSEYPISRNPK--------SLSVDKFRE----SPHHSNSKNKEPGAGRTS
PSESQLF-GNRWYTHSHSSALRNKSCPPQEESVKEVGLEQRQLEDSEPQDSVSESYLPT-
QDTEG-TPYLESGISLFS--------DPESAPAEDRAPGPAPVC----------SSPDSR
STLK----LPQF--QVAESVQS-P------AND-SAGCS-----------SKEESLSLDK
--PESISS-TER

PF00533 // ENSGT00440000034289_0_Domain_3 (1993, 2070)

INKGISMVVSGLTPKEFMLVHKFARKYHITLTNVITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKILDEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVRELSSFTRGT---
GVHPIVVVQPDAWT-------ED-GGFHGIGQMC----AASVVSREWVLDSIALYQCQEL
DPYLIPQSPAAAAEHSRPRV----------------------

-------------------------------MDLSALRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLEYANSYNFAKK-EN-NSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVQLSNLGTVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDEISLD-SAK--KAACEFSETDVTNTEHHQPSNN
D-------------LNTTEKRATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRR-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLCERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLG
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV
ESN-TEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-IIQ---ERPLT-NKLKR
KRRA--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSGHENKT
KGDSIQNEKN---PNPIESLEKESAFKTKAEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKKYNQMPVR
HSRNLQLMEDKEPA--TGVKKSNKPN-EQTSK--RHDSDTFPELKLTNAPGSFTNCSNTS
ELKE------FVNPSLPREEK---EEK--LETVKVSNNAEDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKGLIHGCSK----DT-RNDTEGFK---YPLGHEVNHS-RETSIEMEESEL
DAQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHCRSLKKQSPKVTFEREQ-KEQNQG
KNESNIKPVQTV-NTTAGFPVVCQ--KDK-PVDYAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPIKS-FVKTKCK-----K------NLLEENFEEHSMSPERE
MGNEN-I-----PSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAMLRLGVLQPEVYKQSLPESNCK-HPEIKK----QEY----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHASQVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DCSNQVI-LAKASQEHHLSEETKCSASLFSSQCSE
LEDLTANTNTQDPFLIG--SSKQMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---N
-NQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIS-DSSA--LEDLQNPEQSTSEKDSHIHGQRNNSMFSKRPR
EHISVLTSQKSSEYPISQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCPSL-DDRWYMHSCSGSLQNTNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDKAPESAHVG----------NIPSST
SALK----VPQL--KVAESAQS-PA--AAHTTN-TAGYN-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGLTPE

PF00533 // ENSGT00440000034289_0_Domain_3 (2008, 2070)

EFMLVYKFARKHHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRT
KRLLQSEPENP--SLQETS-LSVPLSNLGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------WNTTEKHATERH--PEKYQ----G----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------EAASGYESETSISEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVEKQQLEKSGPHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSG

PF00533 // ENSGT00440000034289_0_Domain_3 (2004, 2070)

LTPEEFMLVYKFARRYHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----PDRKVKLPPSS------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------MDLSADRVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-RKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 428)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFADSYNFSKK-EN-NSPEHLKE-EVSIIQSMGYRNRA
KRLRQSEPENP--TLQETS-LSVQLSNLGIVRS-LRTKQQIQPQNKSVYIELGSDSSEDT
VNKASSC---SVGDDK-LEITSQGARAEASLN-P--AKKAACEFSG-DITNIEHHQSGNK
D-------------LTTTEKHATKKH--PEKYQ----GISVSNLHVEPCGTNTHASSL--
QHENSSLLLTKHRMNVEKAEICNNSKQPGLARSQQSRWAESKETCNDRQ-IPSTEKKVV-
-----VN

PF12820 // ENSGT00440000034289_0_Domain_1 (428, 604)

ADLLCGRKELNKQKPPHSDSPR-DSQD-VPWITLNSSIRKVNEWFSRSDEILT
SDDSHDRGSELNTEVGGAVEV--PNEVGEYSGSSEKIDLMASDPQDAFICESERVHTKPV
-GGNIEDKIFGKTY-RRKASLPKVSHTTEV-LTIGACAIEPQ-TMQ---THPFM-NKAEH
KRR

ENSGT00440000034289_0_Linker_1_2 (604, 766)

T--TSSLHPEDFIKKVELGIVPKTPEKLIEGINQIKR----DGHVINITNNGPENET
EGDYVQKEKN---ANPTESLEKESAFRTKTEPMSSRISNMELELNSSSS---KAPKK-NR
LRRKSSARHTC---ALEFVVNR-----NLNPPDHSELQIESCSSS

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1153)

EEMKKQ-HLDQVPVR
HNKTLQLMQDKEPA--GRAKKSSKPG-EQINK--RLASHAFPELTLTNVSGFFANYSSSS
KPQE------CINPGLRREEI---EES--RRMTQVSDSTRDPKELVLSGGR-GLQTE---
RSVE-STSISLVLDTD--------YGTQDSISLLEADT---------L-RKAKTVSN-QQ
ANLCATIENPKEPIHGCSK-----DTRNDTEGFV---VPLTCKDNHT-QETSIEMEESEL
DTQCLRNMFKVSKRQSFALFSYPRDPEEDCVTVCPRSGAFGKQGPKVTLECGQ-KEESQG
KKESEIRHVQAV-HTNAGFSAVSQ--KAKKPGDFAKCSIKGVSRLCLSS-QFK-GKETEL
LIANYHGISQNP

ENSGT00440000034289_0_Linker_2_3 (1153, 2006)

YHIPPLSPIRSCV-KTLCQ-----------ENLSEEKFEQHSMSPERA
VGNERVI-----QSTVSTISQNNIRECASKEVGSSSVNEVVSSTNEVGSSVNEVGSSGEN
IQ---AELGRNRGPKLNAMLRLGLMQPEVCKQSLSLSNCK-HPEM-------KWQGQSEG
AVLSVSADFSPCLISD-NPEQPMG-SSRSSQVCSETPDDLL-NGDKIKGK--VSFAESDI
KEKS---------AVFSKSVQS---GEFSRSPSPSDHT--RLAQGY-QRGTKKLESSE--
ENMSSEEEELPCFQHLIFG---------------------------KVTNMPSQSTSHNA
VAAEGLSNKTEENLDSLK--NSLS-DISNQVPS-AKASQEHHLSEEARCSGSLFSSQCSA
LEDLTVNTNTQDPFSMFDPTSKQVRHQSENL-DVLN--DKELVSDDDDEREPGLEE---D
SPQEEQSVDSDLGEVASGYESETSLSEDCSRLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHESQPSNSSPSLIA-DSCS--PEDLLNPEQNASERVN----------------
A---VLTSEKSSDSPISQNPE--------SLSTDKFQV----FLDSSTSKNGEPGMIRSS
PSQSRLL-DTRWYVHSCPRSLQDTNCPSQKELTKVVSMEEQQPTESEARDLMEQSYLSR-
PDLEG-APYLESGISLFSD-------DPESDPSSHRASELAHVS----------SMPTST
SALK----LPQF--QVEESAKS-TA--AVHIAS-TAGYN-----------KSEDSVGIEK
--PEVISS-TRGVNKRISMVASGLT

PF00533 // ENSGT00440000034289_0_Domain_3 (2006, 2070)

PKEFMLVHKFARKHHISLTNLISEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKILDEHDFEVRGDVVNGRNHQGPKRAR
ESQDRESQ

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVHLCGASVVKEPSLFTLSK---
GTHPVVVVQPDAWT-------ED-SGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPRAAADSSQPCV----------------------

----------------------------------------------------------

PF00097 // ENSGT00440000034289_0_Domain_0 (59, 105)

LE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNHITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQIANSYNFSKK-EN-NSSEHLKE-EVSIIQSMGYRNRA
KKLQQSEPENP--TQ-ETS-LSVQLSNLGIVRS-LRTKQQIQPQNKSVYIELGSDSSEDT
VNKASYF---SVGDHELLEITPQGAKAASL-N---RAKKAACEFSEKDITKAEHHQFSNK
D-------------LTTTEKHETEKH--PEKYQ----GIFVSNLHVEPCGTDTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQLVLGKSQQSRWAESKDTCNDRQ-TPSTEKKVV-
-----LNADPLYGRKELNKQKPASSDSPR-DSQE-FPWITLNSSIQRVNEWFSRSDEMLT
SYDSRDGAFESNTEVARAVEV--PKEVDGYLGSSEKIDLMASDPHGALIH--ERVHSKPV
-ESNIEDKIFGKTY-QRKTSLPNLSRIAED-LIIGASTVEPQ-ITQ---ERPLT-KKLKR
KRRS--TSGLHPEDFIKKVDLAVLPKTPEKIIEGTDQTEQ----NGHGINITSNGHETEM
KGGYVQKEKN---ANLTESLEKESAFRTKAEPISSSISNMELELNIHSS---KAPK--NR
LRRKSSTRNIH---ALELAVSR-----NPSPPHHTELQIDSCSSSEEMKKK-HSSQMPVR
HGKKLQFMGDKEPT--TGAKKSDKPH-KQITK--RLASDTYPELNLTNIPVFFTHCSGSN
KLQE------FVNPSLQR------EES--LGTIQVSNNTKDPKDLTLSRGK-GLQIE---
RAVE-STSISLVPDTD--------YGTQDSISLLEADT---------L-GKAKTAPN-QH
VSLCAAIESPKELIPGCSK-----DIRNDTEDFQ---DPLGHDVNHI-QKASIEMEESEL
DTQYLQNMFKVSKRQTFALFSNP---EKECATVCAHSGSLREQSPRVPLECRQ-KEENQG
KSESKIKHVWAI-NTTVDFPVAGQ--KDKKPSDHAKRSPERVTRLCQSS-QFR-GNKTEL
IIANKHGISHNPYLIPSLSPIRSSV-KTICK-----------KNLSEEKFEEPVMSPERA
MENESIV-----QSTVRTISQNNSRESTFKEVNSSSINEVGSSTNEVGSSINEVGSSGEN
IQ---AKLDRNRGPKLSASLRLGLMQPEVYKQSLPVSNCQ-LPEI-------KRQGENEG
TLQAVNEDFSPCLNPD-NLEQPMG-RSHASQVCSETPDELL-NDDKIKE---SNFAESDI
EERS---------AVFSKSVQK---GEFRRSPGPLAHH-TSLVQGH-ERGA---ESSE--
ENVSSEDEELPCFQHL-FG---------------------------KVTNTLSPSTRHNA
VATEGLSKETEENLISLK--NSLN-DCSDHVTS-AKASEEHHLHEEARCSDSLFSSRCSA
VEDLTANTNTQDPFLMFDPLSKQVGHQSDNQE-VLS--DKELVSD-DDERETGWEE---D
NHQEEQSVDSDLGEAASEYESETSLSEDCLGLSSQSDILTTQQRDTMQDNLLKIQQEMAE
LEAVLEQHGSQPSHSSPSLIA-DSCA--SEDLLNLEQNTSEKA-----------------
----VLTSEKSSEYPISQNPE--------SLSADKFQV---SPDT-STSKSKEPGMERSS
PSKSQLS-DNSWYMHSHSRSLQSRNCPPQKEL-EAVDVEEQQLTESEAQDLMEQSSLPR-
QDLEG-TPYLESGISLFSD-------DPESDPCEDRAPEPAHVC----------SMSPSA
SALK----LPQF--QAEESPRS-PA--AAHTTN-TAGCN-----------VREESVSREK
--PELIPS-TQRGNKRIS

PF00533 // ENSGT00440000034289_0_Domain_3 (1999, 2070)

MVASGLTPKEFVLVHKFARKHHITLTNLITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFKGLEICCYGPFT---NMPTDQLEWMVHLCGASVVKEPSSFTLSQ---
GTQPVVVVQPDAWT-------EG-GGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQVPSCC------------------------------

MKLSFYKPFFKLYICIYIFFLMCLSSLEQKEMDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNDITKRSLQESTRF
SQLVEELSKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPKNP--SLQETS-LSVPLSNLGIVRT-LRTKQQIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IKDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLILSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTERN-KC
MSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGSEVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQ-KEENQG
KKQSNIKPVQTV-NITAGFSVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSPERA
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
LVQTVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSIQR---GELSRSPSPFTHT--HLAQGYRK-EAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGPHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
SFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MGYRNRA
KRLRQSEPENP--SLQETS-LSAQLSNLGIVRS-LRTKQQTQLQSKSVYIELGSDSSEDT
VNKASYC---SVGDQELLQLTSEGARAETSLD-P--AKKAACEFSE-DLTNIEHHQSSNK
D-------------LNTIEKHATERH--PEKYQ----GISVSNLHVEPCGTNTHANLL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARRQQSRWAESKETCNDRQ-TPSIEKKVD-
-----VDADPLYGRKELNKQKPPCSESHR-DTQD-IPWIMLNSSIQKVNEWFSRGDDILT
SDDSHDRGSELNAEVAGALKV--SKEVDEYSSFSEKIDLMAINPHDTLQFASERVQLKPA
-ESNIKDKIFGKTY-HRKASLPNLSHITED-LFIGAIAAEPK-ITQ---EHSLT-NKIKR
KRRT--ASGLRPEDFIKKVDLTVVQKTPEKINQGTDQMEQ----NDPVMNIANSGHENET
KGDCVQKEKN---ANPTESLGKESAFRTKGEPISSSISNMELELNIN-S---KASKK-NR
PKRMSSTRHIH---ALELVGSR-----NPSPPNHTELQIDSCSSI

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1152)

EEIEKI-NSNQKPIR
HNRMLQLTKEKETT--TGAKKNNKPN-EQISE--RHASDAFLEL--KNVTDFLPKCSSSD
KLQK------FNS-SLQ-GEV---AEN--LETIQVSDSTRDPEDLVVSGEK-CLQTE---
RSAE-STGISVVPDTD--------YGTQDSISLLEADT---------L-GKAKTALN-QH
VSQYVAIRNATELSHGCSK-----DTRNDTEDFK---DPLRHEVNHT-QGTNVEIEESEL
DTQYLQNTFKISKRQSFALFSN---PENECATVCAHSRFLGKQSPKVTFECRH-KEENQG
KKESKIKHVQVI-HTTAGFPIVCQ--KDK-PGDYAKGSIQGVSRLCQSS-QAR-GNESEL
INSNEHEISQN

ENSGT00440000034289_0_Linker_2_3 (1152, 2006)

PDQMPSLSHMKSSV-KTKCK-----------ENLSEEKFEELTVSLERT
MVNENII-----QSTVSTISHSNIRENTFKEASS--------------SSINEVGSSDEN
IQ---AEVGRNRAPKLNAMLRLGLMQPEVYKQSLPITNCK-YPEI-------KSQGENEE
AIRAVDIDFSPCLISD-NLQLPMG-NSCASQICSETPDDLL-DDDEIKEN--NCFAESDI
KERS---------AIFSKTVQK---REFRRSPSPLVHT--SFAQGH-QRKPRKLDSSE--
EDVSSEDEELPCFQHLLFG---------------------------KVTNIPSQR---SA
VSMECLSKITEENLVLK---NSMN-DCSNQVSL-LKASQEHPLSEEARCSSSLFSSQCSA
LEDLTANTNTQDPFLMFDPPSKQVRHQFENEEVVLS--DKDELIADDHERETSLEE---D
NYQEDQSVDSNLGEAASGYENESSLSEDCSELSSQSDILTTQQRDTIQDNLIKLQQEMAE
LEAVLEQHGSQPSNCSPSLIA-GSGA--PEDLLNPEQITSGKG-----------------
V---VLTSEKSSEHPISQNPE--------GLSADKFQV----SADSSTSENKEPGVQGS-
SSRSQLL-NSRWDEPSHSRSLQNGNCLSQDELVKVIDVEEEQLEKSEACNIIEQSYLPR-
QDLEG-TPYLESGISLFSD-------DPEYDLSEGKAPDLAPIG----------SMPTSA
STLK----LPQF--QVAESPKS-PA--VVHTAN-ITGYD-----------MREESASREK
--PEVISS-TEEVNKRISMVASGLT

PF00533 // ENSGT00440000034289_0_Domain_3 (2006, 2063)

PKEFMLVHKFARKHHSTLTNLITEETTHVIMKTDV
ELVCERTLKYFLGIAGGKWVVSYFC-----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------LSCSRMDIEGIRNVISVMQ

PF02891 // ENSGT00440000034289_0_Domain_0 (51, 108)

KNLECPICLE
LMKEPVATKCDHIFCKFCMLQL---------LSKKKKENVPCPLCKTEVTRRSLQESHRF
KLLVEGLLKIIKAFELD--SGCKFFPSQENTVSGFESTIKDVLIKEDQPVVHCKGYRNRK
KGILKSKTFEVTGTLLESK-PEAQFAKLVTRLTSCRQK-KHRKEASPIFVNCVPDSSECH
LLNNESG----SGNDR-SPLCEKEDTLNPDMEAMVGSDQAECEFSETAERTGSNLPGSDG
----------------------------------------------PGCITETSAETNVN
TAANSNIYA-REAEQYLNEHLCRFKQDIA------DRVHQRNQHCGNVPFVPNLETNFDE
EETIETDFDNQYDDSNPQNIDPLC-----------KVAKLMRRSTERVNEWLLKTNEESS
TLLAEEDS------SFSVFPLQNKEPSEKGSCSSN--DLMPVLHKHAEQGTSGSVFDKQ-
-AVGVKDKIFCKVY-KRQQKSLPPNNITCV-VEVHRDSSF---GTGTENKTLRM-DQLMC
KRKI--AHGLNPENLAITNGSI--NIYPDDCISEAD-VEQ-DAQSKACSELADADQSELV
HCTYTV---------------------DGNTPKKRCVESLANALETREE-------Q-KK
LSCERSQKKKCCTWAVQSVASEPETRLLQSSCGHLDLLLVSSQSIDDPKNV----INQVR
RSRRLQMLPGLLEK--AISNAGFEPKIKN-----------------------------AN
QQQN------GIQSSKFKV-K---EKN------PMS-------DTVPSQMK---------
-----KKDMFCLPFTSDDTDTSMNDGSEEGVPMRKGST----------------RN----
-----------------------HDKVHCNDGDC---DTLLCVTESDVQPNDKETEESEL
ETQQIVKMFKTSKRTSFILDSRAAEAVAEVT---LSSDILQV---KASYDV---------
--------------------------------EYRDVSSLGSAK-EQSS-ALT--NESSP
SS-EPKKSSSLPWHKKRKQQAKSKH-GKMCR----------------SRRENSK--PTDN
RAKSPII----------NMSH----------------------------SSNTIGQPADL
N----SPIHGGTG--------------SIYKQV--INHCPTRPNID--GE---YINASAN
GSQSSVTDKSPAHF-------NIN-TNFICDVNSATPDGLLHSMDNAEGN--SSLGDTTV
HDEG---------KNAAH--------PESFLPSSV-HR-SVGLTGE-KKCIPKVQSSE--
EGSS--GDDLLGSQGLFCQ---------------------------KSKCVSSGATDQKN
SKNPG--NAQRRNLPDFS-GSSNS-GKYNSREM-LCKAVFPSLSQESQCSVSLFSSLSNM
SQQSANEDHKLQGGG-LGSPSRT------EETTISS--DEETLTA---------------
-APQDHNQNPDI-AEASECESEASHTGDSSLLSSQDELLNTQQRDYMKDSLKKLQQEMAA
LEAVLEQHGTQNLSAGTACIPS------AEHVTYRQEEAVEK------------------
E---IA----QGDNSIVRTPP--------KPDANGSALIGQSTDNGLQSRNR-----SMS
PAPPHFLSQTRAE-----KNTQERVGPAM-----------------GISKVLKKSLVTE-
HKLEV-RPDLETANVMPANPMDAKESSGQSSENKSENPILRNKCSTSHQGLFSYSMEEAV
SPHNPKQSRAEF--GIARKSTS-PT-------F-ASPSR-----------AKVLSVGIKS
--P-----

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-VVSSRRNLSFVASGLNQSELAVVQRFSRTTQSILSTRITDSTTHVIMKTDA
ELVCERTLKYFQGIAGRKWVVSYEWVVQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

FKEGQVLDEYDFEVKGDVINGRNHRGPRRSR
LG-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

SDGLLLKDFEICFSGLFT---DMTLDDLEWMVSECGSTVVRDLQFPKNKL---
NTTSLVIVQTDANT-------TEIRDYFAIRKNH----KAIVVTREWLLDSIATYRLQKF
DTYLA-------------------------------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLQYANSYNFAKK-EN-NSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-PSVQLSNLGTVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTSDEISLD-SAK--KAACEFSETDVTNTEHHQPSNN
D-------------LNTTEKRATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRQ-TPSTEKKVD-
-----LNADPLCERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLG
SDDSHDGRSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV
ESN-IEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-IIQ---ERPLT-NKLKR
KRRA--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSGHENKT
KGDSIQNEKN---PNPIESLEKESAFKTKAEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSS

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1153)

EEIK-KKKYNQMPVR
HSRNLQLMEDKEPA--TGAKKSNKPN-EQTSK--RHDSDTFPELKLTNAPGSFTNCSNTS
ELKE------FVNPSLPREEK---EEK--LGTVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKELIHGCFK----DT-RNDTEGFK---YPLGHEVNHS-QETSIEMEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTFECEQ-KEENQG
KNESNIKPVQTA-NITAGFPVVCQ--KDK-PVDYAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLSQNP

ENSGT00440000034289_0_Linker_2_3 (1153, 2005)

YHIPPLFPIKS-FVKTKCK-----K------NLLEENSEEHSMSPERE
MGNEN-I-----PSTVSIISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRSRGPKLNAVLRLGVLQPEVYKQSFPGSNGK-HPEIKK----QEY----EE
VLQTVNTDFSPCLISD-NLEQPMR-SSHASQVCSETPNDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DYSNQVI-LVKASQEHHLSEETKCSASLFSSQCSE
LEDLTANTNTQDRFFIG--SSKQMRHQSESQGVGLS--DKELVSD-DEERGTDLEE---N
-NQEEQGVDSNLGEAASGYESETSVSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIS-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPISQNPE--------GLSADKFEV----SADSSTNKNKEPGVERSS
PSKCPSL-DDRWYMHSCSGSLQNGNYPSQEELIKVVDVEKQQLEESGPHDLTEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQL--KVAESAQS-PA--AAQTTN-TAGYN-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGL

PF00533 // ENSGT00440000034289_0_Domain_3 (2005, 2070)

TPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DRKIFRGLEICCYGPFT---NMPTDQLEWIVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

----------------------------------------------------------L

PF00097 // ENSGT00440000034289_0_Domain_0 (60, 105)

E
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFAKK-EN-NSPEHLKD-EFSIIQSMGYRNRA
KRLRQSEPQNP--TLQETS-LSVQPSKPGIVRS-LRTKQQIQPQNKSVYIDLGSDSSEDT
INKKTYC---SVGDQELFQITPQGTKDETSLD-S--AKKAPCEFSEKDITNTEHHQSRNN
N-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRRNVEKAEFCNKSKQPGLARSQHNRWAESEETCNNRQ-TPSTEKKVD-
-----LDA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLHGRKEWNKQKPPCSENPRDDTED-VAWITLNSSIQKVNEWFSRSDELLT
SDDSHDEGSESNAKVAEALEV--LNEVDGYSSSSEKVDLLASDPHDALICKSERVYCKSV
-ESSIEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-ITQ---ERPLT-NKLKR
KRRI--TSGLHPEDFIKKADLAV-QKTPEKINQGTNQMEQ----NDQVMNIANSGHENKT
RDDSIQNENN---PNPVESLEKE-SFRSKAEPISSSISNMELELNIHNS---KASKK-NR
LRRKSSTRHIH---ELELVVSR-----NLSPPNYTEVQIDSCSSSEEIKEK-NDNEMPGR
HSRKLQLMEDEECT--TGAKKSSKPN-EQTSK--RRASDTFPELRLTNVPGTFTNCSNTN
ELKE------FVNRSLPREEK---EEK--LETVKLSNDAKDPKDLMLSGEN-VLQIE---
RSAE-SSSISLIPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQSAAFENPKELIHGCSK-----DTRNGTEVFK---YPLGPEVNCS-QKTSIDMEESEL
DTQYLQNTFKVSKRQSFALFSNTGNPEKECATFSAHSRSLKKQSPKVTLEYEQ-KEENQG
EKESNIEPVETV-NITAGVPMVCQ--KDK-PVDYAK-CIEGGSRLCLSS-QFR-GNETGL
IIPNKHGLLQNTYHIP-LIPTRSFV-KTKYK-----------KNLLEENSKEHSMSPERA
MGNKNII-----PSTVSTISHN-NRENAFKETSSSSINEVGSSTNEVGSSVNEVGSSDEN
IQ---TEIGRNGRPKLNAMLRLGLLQPEIYKQSLPVSNCK-HPEI-------KKQE-H-E
VVQTVNTDLSPCLISD-NLEQHVG-SSHTSQVCSETPDDLL-DDGEIKED--TSFAEYGI
E-TS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQVY-KRGAKKLESSE--
ENLSSEEEELPCFQHLLFG---------------------------KVSNTP-QSTRHST
VATECPSKNTEENLLSLK--SSLN-DCSNQVIL-AKASQEHHLSEETKCSGSLFSSQCSE
LEDLTTNTNTQDPFLIDS--SKRMRHQSESQGVGLS--DKELVSD-DEERGTDLEE---D
N-QEEQSMDSNLGEAAFGYESETSITEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSHSPPSIIT-DSSA--LEDLRNREQSTSE--K----------------
A---VLTSQKSSEYPISQNPE--------GISADKFEV----SPDSSTSKNKEPVVERSS
PSKCQSL-DDRWCMHSCSGSLQNGNYPSQEEL-IKVDMEEQQLEKSGPHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESSHAG----------SVPSST
STFK----VPQF--QVAECAKS-LA--APHATN-TAGHN-----------AMDESVSRKK
--LELAAS-TEGANKRMSMVVSGLTPEE

PF00533 // ENSGT00440000034289_0_Domain_3 (2009, 2070)

FVLVYKFARKHHITLTNQITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

IKERKMLNEHDFEVRGDVVNGRNHQGPRRAR
ES-----QG

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2211)

RKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GIHAVVVVQPDAWT-------ED-SGFHAIGQMC----EVPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLPAGEVQEVQGVLADM

PF11789 // ENSGT00440000034289_0_Domain_0 (50, 105)

QKNLECPICLE
LIREPVSTKCDHIFCKFCILKL---------LRK-KKGPSQCPLCKHDVTRRSLQESPRS
NKLVEGCGTPSVPSNATRASGFLAARSRA---------AVPLLST-QRKTWP--PFRL--
-RVTGTEPRGT----KPTA-KEVQLR----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLQYANSYNFAKK-EN-NSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-FSVQLSNLGTVRT-LRTKQQIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDEISLD-SAK--KAACEFSETDVTNTEHQQPSNN
D-------------LNTTEKRATERH--PEKYQ----GSSVSNLHVELCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRQ-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLCERKEWNKQKLPCSENPT-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHESLICKSERVHSKSV
ESN-IEDKIFGKTY-QRKASLPNLSHVTEN-LIIGAFVTEPH-IIQ---ERPLT-NKLKH
KRRA--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NVQVMNITNSGHENKT
IRDSIQNEKN---PNPIESLEKESAFKAKTEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEKK-KKKYNQMPVR
HSRNLQLMEDKEPA--TGAKKSNKPN-EQTSK--RPDSDTFPELKLTNAPGSFTNCSNTS
ELKE------FVNPSLPREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKELIHGCSK----DT-RNDTEGFK---YPLGHEVNHS-QETSIEMEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEEYATFSAQSRSLKKRNPKVTFECEQ-KEENQG
KNKSNIKPVQTV-NISAGFPVVCQ--KDK-PVDYAKCSIKGGSRFCLSS-QFR-GNKTGL
ITPNKHGLLQNPYHIPPLFPIKS-IVKTKCK-----K------NLLEENSEEHSMSPERE
MGNEN-I-----PSTVSTISRNNIRESAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAMLRLGVLQPEVYKQSLPRSNCK-HPEIKR----QEY----EE
VVQTVNTDFSPCVISD-NLEQPMG-SSHASQVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DCSNQVI-LAKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKQMRHHSESQGVGLS--DKELVSG-DEERGTGLEE---N
-NQEEQSVDSNLGEAASGYASETSVSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSHSYPSIIS-DSSA--LEDLQNPEQSTSEKDSHICGQRNNSMFSKRPR
EHISVLTSQKSSAYPISQNPE--------GLFADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-DDRWYMHSCSGSLQNGNYPSQEELIKVVDVEEQQLEESGPHDLTEPSYLPR-
QDLEG-TPYLESGISLFSD-------DSESDPSADRAPESAHVG----------NIPSST
SALK----VPQL--KVAESAQS-PA--AAHTTN-TAGYN-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGLTPEE

PF00533 // ENSGT00440000034289_0_Domain_3 (2009, 2070)

FMLVYNFARKHHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

---------------------------------------------FNSTLLNPDLPLDI-
VIYVNLSTKGSNLNCSF---FIIYRFCMLKLLNQ-KKGPSQCPLCKNDITKRAYIGFL--
----LVSLIIIHTFF------SNFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SL-ETS-LSVPLSNLGIVRT-LRRKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNAEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
EIN-IKDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRSLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPEDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTERN-KC
MSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGREVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSEREQ-KEENQG
KKESNIKPVQTV-NITAGFSVVCQ--KDK-LVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSSERA
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
IVQMVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIQED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRK-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGPHDLMELSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGCN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLSADHVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSRK-EN-NSPEHLKE-EVSIIQSMGYRNRA
KRLWQSEPENP--TLQETS-LTVKLSNLGIVRS-LRTKQQTQSQNKSVYIELGSDSSEDT
VNKASYL---SVGDHELLEITPQGAKAKTNLN-P--AKKAACEFSEKDITNTEHHQLSIK
D-------------LITTQEHAAETH--PEKYQ----GISVSDFHVEPCGTDTHASSL--
QHENSSLLLTENRLNVEKAEFCNKSKQPVLVKSQQSRWAESKGTCKDRQ-IPSTGKKIV-
-----LNTDPLYGRKELCKQKPACSDSPG-DSQD-VPWVTLNNSIQKVNDWFSRSDEILT
SDDSCDGGSESNNEVAGAVEI--PNNVDGYSGSSEKIDLMASDPHGTLIH--ERVHSKPV
-ESNIEDKIFGKTY-RRKSSLPNFNHIAED-LIIGAFTVEPQ-KTQ---EQPLT-NKLKC
KRRG--TSGLQPEDFIKKGDLTIVPKTPEKMIERTDQTEQ----KHHGINITSDGHENKT
KRDDVQKEQN---ANPTESLENESVFRTKAEPINTSISNMELELNVRSS---KAP-K-NR
LKRKSSTRKIP---ELELVVSR-----NPSPPNHTELLIDSSSSN

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1152)

EEMKKK-HSSQMPVR
HSQKLQLMGDKEPT--AGAKKSNKTY-EQINK--RLASDAFPELNFANTPGYFTNCSSK-
-PEE------FVHPSLQRE------EN--LGTIQVLNNTKDPKDLILRGGK-ALQME---
RSVE-NTNISLVPDTD--------YSTQDSISLLEAKT---------P-EKAKTAPN-PC
VSLCAAIENPKELIHRDFK-----DNKNNTEGFQ---GLLGHDVNYVIQETRGEMEDSEL
DTQYLQNTFKVSKRQTFALFSNPGNPQKECATVFAHSGSLKDQSPRDPLKCRQ-KEDSRG
KSESKSQHVQAV-CTTVHFPVAGQ--KDKTPGDDAKCSAKEVTRVCQSL-QLR-GHKTEL
VFANKQGVSEK

ENSGT00440000034289_0_Linker_2_3 (1152, 2003)

PNLTPSLFPIKSSV-KTVCK-----------KSPS-EKFEEPVMSPERT
LGSESII-----QSAVSTISQNDIQGSTFKEVNSSSVNEVGSSTNEVGSSINEVGSSGEN
IQ---AEPGRNREPKLRALLRLGLMQPEVYKQSLPVSNCH-HPEI-------KRQGENED
MLQAVKADFSPCLISD-NLEQPMG-SCHASQVCSETPDNLL-NDDEIKEN--SHFAESDI
KERS---------AVFSESVQK---GEFRGSPGPFTHT--HLAQGH-QRGAGKLESA---
ETVSSEDEELPCFQQLLFG---------------------------KVTDTLSPSTGWNT
IATEGLSKETEENLESLK--SGLN-DCSGQGTS-AKVSQEHHLNEEVRCSGSLFSSQYSA
VEDLTTNTNTQDPFLMFERPSKQVYQSE-SE-EVLS--DKEFVSD-DEERETGLEE---D
SCQEEQSVDSDLGEAASDHVSETSLSEDCVGLSSQSDILTTQQRDTMQDNLLKLQQEMAE
LEAVLEQHGSQPSHSSASLTA-DSRG--PEHLLNLEQDTSE--R----------------
A---ILTSEKSRDCSRSQNPE--------SLSADKFPV----SLDSSTNKNKEPGMERSS
PSKSQLP-GNRWYMHSS-RSLQDRNCPSQKKRINVADMQEQQLAKCEAQDLM-GSYLPR-
QDQEG-TPYLKSGISLFSH-------EPESDPSEDRAPEPAHVH----------SMPPTA
SALK----LSQF--RVEESTKN-PA--AAHITN-TTGCN-----------LREESVSKEK
--PEVLSS-TERSNKRLSMVAS

PF00533 // ENSGT00440000034289_0_Domain_3 (2003, 2070)

GLTPKELMLVQKFARKHHVTLTNLITEETTHVIMKTDP
EFVCERTLKYFLGIAGGKWVVSYFWVIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----R

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DKKIFKGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKEPSSFTPGQ---
GTHPVVVVQPDAWT-------ED-AGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLVPQVAQSCC-----------------------------

-------------------------------MDLPTVTIEEVKNVLIGMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTTCDHIFCRFCMLKL---------LSK-KKGPSQCPLCKNNITKRSLRESTRF
NQLVEGLLKTIRAFELD--TGFQFSNTQDFSKW-ER-RTPEPLKK-EAATIQSIGYRNRS
KRFKASESENS--TLE-SS-LGVQLYDLGIRKG-SLRKQKKCIKNNAVYIKLGSDSSEDG
VKNAICN---SVKDQGLCQTSPKGTRL----K-S--KEKAEYEFSERAIKSLQQHQSNTV
D-------------VHVINENATEGH--SEESR----GVSSSDLNMKPWNTDIHASSL--
PPEITSVLTNTVSMNIEKAELCDKSKRPGLARSQQISQDNNKEKCSAGK-TSYAEVPHE-
-----LNPHHLYERQELEE-QPECPKYPRGNPQNCLSGTKLKSSIQKVNDWLSRSNDILV
SDYSSVRIHEQNAEMASVLEIGHPDTTDGNSSISGKTDLVADSTDGAWLHMSERSCPRQA
ENNNIEDKIFGKTY-HRKSVHTNLNYITEN-LIVGAVASDCL-IPP---EHVKQ-TRLKR
KRKT--ISDLQPEDFIKKTDTEFIHKSPEKKIHAVDQILE-QEQNGQVMNTVNGHLEQKA
LVDGHVEEVNDALASELLPVEKESTFRTGTDSAAGSINHRGLKLNGRNA---KMTKK-DK
LRKKSSARIVH---ELELIVDK-----NPSSSNETELQIDSYPSS

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1150)

EEIRKGNNSEQKQIR
RSRRLQLLSEE-IA--METKKAYEPD-EQAEK--SCVNEVFPDLKMGNIPACDTVSLTTE
SDQM------LASCSVTEEGH---EKS--LEAVQSS---QDQEDLAISGGE-GSQGQ---
RAKG-NLEALEVPDTD--------WDTQDSTSLFPANT---------P-QNSKAGPN-PH
RSQCEIMETPKELLDGCSS----ENTGSTTEDLR---GLMRQGVKNA-SETTTEMEDSEL
DTQYLQNTFKRSKRQTFALGSS---PRQECMKPCAISQALHQRGLHNATDCGD-HEKEKL
GNRESNKPVQAK-SAVMNLAVVCQ--IERKPSDCAS-----VSRICHID-PLHGGNDCEF
IAGNNEEIS

ENSGT00440000034289_0_Linker_2_3 (1150, 1999)

QVPNQKQSVSPAGSSTSKIIYT-----------KNLLEENLDE--ISPETA
VGNEILA-----QSSLSLVSPSNSRDCVSKVADL--------------NRFIGIGSNGEG
SQ---AEKHKNKESELNTLPKLKLVQPQVCQQSFPQDNFSKEPER-------EEKEENVK
LTPAISADSSPCLE------QTKE-NTHFTQVWSETPDLLD-SDGELKEN--TSFAESDI
KEQS---------AVFGKNGKSSQVRKSRKNLSPLVHRNPSLSWKS-RRQARKLESSE--
EEASSEEGELPSFQDLIFG---------------------------KAASTPFQPTKNKT
IAKEFSANEAKENLAFLN-RNNMS-VNNLQIPS-GEASQDHDSSQESECSGSLFSSHSNS
LEDLAGKANDKDSALVFGSSHQESSHSRTQEIQSGS--EMPKASQDKEERETDLDE---D
HHPKDQGVDSNLVVEGSGYDSETSHPGDTSQLSFQSDILTTQQRDTMQDNLKKLQQEMAV
LEAVLEQHSSQVTNNSSSQEP-GLCP--SMDQPDLKQTNSERG-----------------
-------AEENVDHHKSQNVQ--------SFSADKSRA----FPSDSNSKNEEAGVEGSS
FSKSQMP-NRVWSPLSRSRTPWEGDSPSEESGKVTTRKEEHK-------RQPNEQGVLK-
QNLEI-TTEPESGVKVNLK-------NIKSNPHQNKDPALRNIF----------NLPTST
SALR----SSQL--QTIEATNT-TA--PC-----APACN-----------VRGQLKEDSA
--SERLKK-GGTGNRKIS

PF00533 // ENSGT00440000034289_0_Domain_3 (1999, 2069)

LVSSGLTPKENMLVQKFARKTHSTVSHQITEGTTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSFLWVVQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2109)

SFKEGKMLPECDFEVRGDVINGRNHRGPERAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

GMKIFRGLEICCYGPFT---DMSTDQLEWMVQLCGASVVKKPSSLRFRV---
GSSPVVVVQPDAWE-------DD-SSFQEIGLVC----EAPVVTREWVLDSVACYQRQEL
DTYLISQTSPSLC-----------------------------

-------------------------------MDVSADRVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLRIIHAFELD--TGLQFAHSYSFSKK-EN-DSPERVKE-EVSIIQSMGYRNRA
KRHRQSEPENP--TLQETS-LSVHLSNLGIVRS-LRTKQQIQPQNKSIYIELGSDSSEDT
VNKASYC---SLGDHELLQITPQGARAEASLN-P--TKKAACEFSEKAITNIEHHQSSNK
D-------------LTTTEKHAAEKH--PEKYQ----GISVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLAKSQQSRRAESKETCNDRQ-APNSEEKLV-
-----LNADPLYGREELNKQKPPRSDSPR-DSQD-VPWITLNSSIQKVNEWFSRSEEMLT
SDDSCDGGPESNTEVAGAVEV--PNEVRGYSGSSEKIDLMAGDPSSALICESERVRSKPV
-ENNIEDRIFGKTY-RRKASFPNLSHITED-LIIGASAIEPQ-ITQ---ERPLT-NRVKH
KRRT--SSGLHPEDFIKKVDLAVVQKTPEKIIEGTDQIEQ----NSHVMNITPNGHGNET
KGDYVQNEKN---ANLTESLETESAFRTKAEPISSSIGNLELELNIHSS---KAPKK-NR
LRRKSCTKQIH---ALELVVSK-----NPSPPNHTELQIDSCSSS

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1153)

EEMKKK-NSDQMPVR
HSKKLQLMEDKEPA--TGAKKSNKPN-EQINK--RLASDAFPELKLTNIPGFFTNCSSSN
KLHE------FVNPSLQREEI---EQN--LGANRLSNSAKDPKDLILSGGK-CLQAE---
RSVE-SSGISLVPDTD--------YGTQDSISLLEADT---------L-GKAKTAPN-QC
ANLCAAIENPKELTHDCSK-----DTRNDTQGVK---DPLRREVNHT-QETSIEMEESEF
DTQYLQNMFKVSKRQSFALFSNPGSPEKKCATVSAHSRSLRKRSPKVTLKCGQ-KEGKEG
KKESKIKNVQSV-HTTVGFPVICQ--KDKKPGDYVKCSTKEASRLCQSS-QFR-GNETEL
ITANKHGISQNP

ENSGT00440000034289_0_Linker_2_3 (1153, 2006)

YYIPSLSPIRSSV-KTVCQ-----------KNLPEGKLEEQSLSPERA
MGNESIV-----QSTVSTISQNNIRESTLKEVSSSSINEVG-------SSINEVGSSGEH
IQ---AELGRNRGPKLNAILRLGLMQPEVYKQSLPISNCK-HLEI-------KRQGEK-E
VVQAVNADFSPCLISD-NLEQPMG-SSCASQVCSETPDDLL-NDDEIKEN--ISFAESGV
KERS---------AVFSKSVQK---GKFRRSPSPIGRT--CLAQGH-QRRARKLESSE--
ENTSSEDEELPCFQHLLFG---------------------------KVTNLPSQSTSH-A
AATEGLSKKTEESLVSLQ--NSLD-DCSHQVAL-AEACQEHHLSEEARCSGSLFSSQCSA
LEDLPANTNTQEPVLMFDPPSKQVREQSENH-EVVS--DKELVSD-DDEREPGLEE---D
SHHEEQSVDSILDEVASGYVSETNLSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQKMAE
LEAVLEQHGSQPSNRSPSLIA-DCCA--SEDLLNPEQNTSE--R----------------
A---VLTSEKSSEYPISQNPE--------NLSADKFQI----SLDSSTSKNREPEMERSS
PSKSQLL-DNRWCVHSHSRSLQNRNCPSQKEFIKAVDAEEQQLTKSEAQDLMEQSYLPR-
QDLEA-TPYLESGISLFSH-------EPESDPSEERALEAAHVC----------SMPAST
SAMK----SLQF--RVEESAKS-PA--GAHTTN-IVGSN-----------VKEDSVSREK
--PEMISS-TERVIRRISMVASGLT

PF00533 // ENSGT00440000034289_0_Domain_3 (2006, 2070)

PKEFMLVHKFARKHHITLTNLVTEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKVLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DRKIFRGLEICCCGPFT---NMPTDQLEWMVRLCGASVVKEPSSFTFSE---
GTHPVVVVQPDAWT-------ED-SGFHMIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQVP---------------------------------

-------------------------------MDLSVIAIGDVQNVLSAMQKNLE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPVCLD
VIKEPVSTKCDHVFCRFCMFKL---------LSRKKKGVIQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 433)

CKTEVTKRSLKENSRF
KQLIEGLLEAISAFELD--TGVKFLSSRYFPKTSTEVATAELLGN-NSSVIQSKGFRNRK
RGAKENRQDSC--TL-EAN-VDPQLTDNRVKGSSVRSKKQKCGIEKGVLIELGTDSSEEH
FILASST---GLEDKEELEE--------PKSA-E--KYGSSCNTQPLKLGAKEIILPNVI
GETDFLKEALDKKSMLNITEHIKCNQVNTIEGQSSPLNVFDADLLTGQRDGIGNASPL--
KND-TSFLKNAEEMDVEETQCSHKNQELDLEDSSEGRLDKIKEKDICVP-SVEDVEMCE-
-----PMDDSLL

PF12820 // ENSGT00440000034289_0_Domain_1 (433, 604)

EKEP-PVEKPLQPKIPHCPTLNEVSTKRLNQSIQKVNEWFSKSSRILS
SSSSQNDHAEATDASGEG----DISLSDKDSCISEKTNPIVDSVEFA-VIERNKRWTKQT
-TYSIEDKIFGKTY-ERGRKSNPSTILRD---ILPATKKEDAAAEEGCLNNSRK-DRLKR
KRKS--ACILQPEDFIKKKDLEEADRCPQGIKSSLGDAEK-EKCDENSAV-KENPLLEKR
KGSTLAEF----------KER-GLQWKNAAEKVSGKCSDGQLELNNSDQKSTKNACS-TA
KGCRHSTRTRC---AIHLVD-R-----NPGSFDLAEPLINSYPSNEEPSKA-DCERRQVR
RSRRLQLLSEEITK--ETGKMRVIKEAKNSDS--GPEGSVFGVER--NVLVHNSQCKDLR
KQQD------ILSYMSLADRN---GADLEANGIQIS--SKNSDDM-AKNRS-FFNPT---
FSCQLSNFNSPSSKA----------GSQEG-EMLGKLFLPQSPSKTVL-HAASILTEEKR
SWSCTVFSQDKG-----------CCSRNVPKDFRIGKSPMAKNA----SEFTMEAEDSEL
DMQYLRNIFRSSKRQSFSLYPTP---MKACTTDDVASE-------KLNTSCPD-QVEERN
SKYLKTENLQEEKTTAENLSSVCE----KFETCESACV-------SPVS-CFVSSAACVH
TVENQ-DVSKVANHGNLTTLLRICAARNEDGNRPQKGEQGSEKTLST------------G
IGVESKLRLSPVRSNRSQSDQSNTEEHAFQRTGLN--------------AVSETYFSSES
NQVEKAEVVDDKGLMQH-FQPSPMLCPTACQQNPAEFNCELTEKKIITRERSLVKGNEER
VIQTVSTGLSEFSVRE-ALEESLK-GHSDFTDLSETPDGLLCSDNDTEES--ASFYVTNR
KDTS---------AVFVKRSGAAWVKEVNDSVVSCKPR-SEGIQRF-RRRAQKLQSSD--
-EESSDDEDLPSFQELMFG---------------------------KSVSTPLQIQKQVT
SVVQSS---ANPSTLPCS--ECLNENNEQKTLEAALSNECASPSQESECSVNLFSSQSNM
SEESVDGAQELKKTLTQVS------NVKKSKEAPQS--CSGGLKRL--------KNNLND
EYQEDPNMGANLGEA-SGYDSETSRVEDSHEPFSQGEILSTQQKNAMQNNLKKLQQEMAV
LEAVLKQHGSQDAEVLPLCRELPYCS--IGGTLGLERMRQET------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------ENVSEHDSETKLTKASVLPVLCGNV-----TKNPNSSS
FSVK----HPCP--QTAEATDS-SA--VAQGDN-KSNVQVCKSKRSVCFPTSVLHNVAGK
--ENAASS-GTTCRTEMSIVASGLNQSEHL

PF00533 // ENSGT00440000034289_0_Domain_3 (2011, 2070)

MVQKFARKTQSTFSNHITDGTTHVIMKTDE
ELVCERTLKYFLGIAGRKWVVSYQWIIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

FKEGRILDEEHFEVKGDVINGRNHQGPKRAR
QS-----PA

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2211)

EKIFKDFEICCCGPFT---DMTTGHLEWIVELCGASVVKQLHLFTHKV---
NSTAVVVVQPDAWM-------EG-TSYEAIQRKN----NVAVVTREWVLDSVACFECQEL
DAYLVSQD----------------------------------

-------------------------------MDLSAVRIQEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSARF
SQLVEELLKIIDAFELD--TGMQCANGFSFSKK-KN-SSSELLNE-DASIIQSVGYRNRV
KKLRQIESGSA--TLK-DS-LSVQLSNLGIVRS-MKKNRQTQPQNKSVYIALESDSSEER
VNAPDGC---SVRDQELFQIAPGGAGDEGKLN-S--AKKAACDFSE-GIRNIEHHQCSDK
D-------------LNPTENHATERH--PEKCP----RISVANVHVEPCGTDARASSL--
QRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWADSKETCNGRP-VPRTEGKAD-
-----PNV

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 608)

DSLCGRKQWNHPKSLCPENSG-ATTD-VPWITLNSSIQKVNEWFSRTGEMLT
SDNASDRRPASNAEAAVVLEV--SNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPV
-ENIINDKIFGKTY-QRKGSRPHLNHVTE---IIGTFTTEPQ-IIQ---EQPFT-NKLKR
KRS----TCLHPEDFIKKADLTVVQRISENLNQGTDQMEP----NDQAMSITSNGQENRA
TGNDLQRGRN---AHPIESLRKEPAFTAKAKSISNSISDLEVELNVHSS---KAPKK-NR
LRRKSTRCVL----PLE-PISR-----NPSPPTCAELQIESCGSSEETKKN-NSNQTPAG
HIREPQLIEDTEPA--ADAKK-NEPN-EHIRK--RSASDAFPEEKLMNKAGLLTSCSSPR
KPQG------PVNPSPERKGI----EQ--LEMCQMPDNNKELGDLVLGGEPSGKPTE---
PSEE-STSVSLVPDTD--------YDTQNSVSILEANT---------V-RYARTGSV-QC
MTQFVASENPKELVHGSN------NAGSGSECFK---HPLRHELNHN--QETIEMEDSEL
DTQYLQNTFQVSKRQSFALFSKLRSPQKDCTLVGARSVPSREPSPKVTSRGEQ-KE-RQG
QEESEISHVQAV-TVTVGLPVPCQ--EGK-PGAVTMC--ADVSRLCPSS-HYR-SCENGL
NTTDKSGISQNSHFRQSVSPLRSSI-KTDNR-----------KTLTEGRFEKH---TERG
MGNETAV-----QSTIHTISQNNRGD-ACQEASS--------------GSVIEVHSTGEN
VQ---GQLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKY-LE--------------IKQ
ESKAVSADFSPCLFSD-HLEKPMR-SDKIFQVCSETPDDLL-DDVEIQEN--ASFGEGGI
TEKS---------AIFNGSVLR---RESSRIPSPVTHA--SKSRSL-HRGSRKLEFSE--
ESDSTEDEDLPCFQHLLSR----------------------------VSSTP-ELTRCSS
VVTQRVPEKAKGTQAPRK--SSIS-DCNNEVIL-VEASQEYQFSEDAKCSGSMFSSQHSA
ALGSPANALSQDP--DFNPPSKQRRHQAENEEAFLS--DKELISD-HEDMAACLEE---A
SDQEEDSIIP--DSVASGYESEANLSEDCS----QSDILTTQQRATMKDNLIKLQQEMAQ
LEAVLEQHGSQPSGHPPCLPA-DPCA--LEDLPDPEQNRSG--T----------------
A---ILTSKNINENPVSQNPK--------RACDDKSQP---QPPDGLPSGDKESGMRRPS
PFKSPLT-SRRCSARGHSRSLQNRNSTSQEELLQPVELEK----SCEPHNLTGRSCLPR-
QDLEG-TPYLESGISLFSS-------R---DPDSESPKVPALVC----------TAPAST
SALK----ISQG--QVAGSCRS-PA--AGGADT-----------------AVVEIVSKIK
--PEVTSS-KERAER

PF00533 // ENSGT00440000034289_0_Domain_3 (1996, 2070)

DISMVVSGLTPKEVMIVQKFAEKYRLALTDVITEETTHVIIKTDA
EFVCERTLKYFLGIAGGKWIVSYSWVIKS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IQERKLLSVHEFEVKGDVVTGSNHQGPRRSR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QE-KLFEGLQIYCCEPFT---NMPKDELERMLQLCGASVVKELPLLTRDT---
GAHPIVLVQPSAWT-------ED-NDCPDIGQLC----KGRLVMWDWVLDSISVYRCRDL
DAYLVQNITCGRD-GSEPQD-----SND--------------

-------------------------------MDLSADHVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSRK-ED-NSPEHLKE-EVSIIQSMGYRNRA
KRLWQSEPENP--TLQETS-LTVELSNLGIVRS-LRTKQQTQSQNKSVYIELGSDSSEDT
VNKASYF---SVGDHELLEITPQGAKAKTNLN-P--AEKAACEFSEKDITNTEHHQLSIK
D-------------LITTQKHATETH--PEKYQ----GISVSDFHVEPCGTDTHASSL--
QHENSSLLLTENRLNVEKAEFCNKSKQPVLVKSQQSRWAESKGTCKDRQ-IPSTEKKIV-
-----LNTDPLYRRKELRKQKPACPDSPG-DSQD-VPWVTLNNSIQKVNDWFSRSDEILT
SDDSCDGGSESNNEVAGAVEI--PNKVDGYSGSSEKINLMASDPHGTLIH--ERVHSKPV
-ESNIEDKIFGKTY-RRKSSLPNFSHIAED-LILGAFTVEPQ-ITQ---EQPLT-NKLKC
KRRG--TSGLQPEDFIKKVDLTIVPKTPEKMTEGTDQTEQ----KCHGMNITSDGHENKT
KRDYVQKEQN---ANPAESLEKESVFRTEAEPISISISNMELELNIHRS---KAP-K-NR
LKRKSSTRKIP---ELELVVSR-----NPSLPNHTELPIDSSSSN

PF04873 // ENSGT00440000034289_0_Domain_2 (766, 1152)

EEMKKK-HSSQMPVR
QSQKLQLIGDKELT--AGAK-NNKTY-EQINK--RLASDAFPELKLTNTPGYFTNCSSK-
-PEE------FVHPSLQRE------EN--LGTIQVSNSTKDPKDLILREGK-ALQIE---
RSVE-STNISLVPDTD--------YSTQDSISLLEAKT---------P-EKAKTAPN-PC
VSLCTATKNLKELIHRDFK-----DTKNNTEGFQ---DLLGHDINYVIQETSREMEDSEL
DTQYLQNTFKASKRQTFALFSNPGNPQKECATVFAHSGSLRDQSPRDPLKCRQ-KEDSQG
KSESKSQHVQAI-CTTVHFPVADQ--QDRTPGDDAKCSAKEVTRVCQSS-QLR-GHKTEL
VFANKQGVSEK

ENSGT00440000034289_0_Linker_2_3 (1152, 2003)

PNLIPSLSPIKSSV-KTICK-----------KSPS-EKFEEPVTSPEKT
LGSESII-----QSAVSTISQNNIQESTFKEVSSNSVNEVGSSTNEVGSSVNEVGSSGEN
IQ---AEPGRNREPKLRALLGLGLTQPEVYKQSLPVSNCH-HPEI-------KRQGENED
MPQAVKADFSPCLISD-NLEQPTG-SRHASQVCSETPDNLL-NDDEIKEN--SHFAESDI
KERS---------AVFSESVQK---GEFRGSPGPFTHT--HLAQGH-QRGAGKLESE---
ETVSSEDEELPCFQQLLFG---------------------------KVTSTLSPSTGCNT
VATEGLSKETEENLESLK--SGLN-DCSGQVTS-AKVSQEHHLNEEARCSGSLFSSQCSA
MEDLTTNTNTQDPFLMFERPSKQVYQSE-SE-EVLS--DKELVSD-DEERETGLEE---D
SCQEEQSVDSDLGEAVSDHVSETSLSEDGVGLSSQSDILTTQQRDTMQDNLLKLQQEMAE
LEAVLERHGSQPSHSSASLTA-DSRG--PEHLLNLEQDTSE--R----------------
A---ILTSEKSRDYSRSQNPE--------SLSADKFPV----SLDSSTNKNKEPGMERSS
ASKFQLS-DNRWYMHSS-RSLQDRNCPSQKEPINVADMEEQQLAKREAQDLM-GSFLPR-
QDQEG-TPYLKSGISLFSH-------EPESDPSEDRAAEPAHVH----------SMPPSA
SALK----LSQF--RVEESTKN-PA--AAHIAN-TTRCN-----------LREESMSKEK
--PEVISS-TERSKKRLSMVAS

PF00533 // ENSGT00440000034289_0_Domain_3 (2003, 2070)

GLTPKELMLVQKFARKHHVTLTNLITEETTHVIMKTDP
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKEGKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----R

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

DKKIFKGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKEPSSFTPDQ---
GTHPVVVVQPDAWT-------ED-AGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLVP------------------------------------

-------------------------------MDLSAVQIQEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSTRF
SQLAEELLRIMAAFELD--TGMQLTNGFSFSKK-RN-NSCERLNE-EASIIQSVGYRNRV
RRLPQVEPGNA--TLK-DS-LGVQLSNLGIVRS-VKKNRQTQPRKKSVYIELDSDSSEET
VTKPGDC---SVRDQELLQTAPQEAGDEGKLH-S--AEEAACEFSE-GIRNIEHHQCSD-
D-------------LNPTENHATERH--PEKCQ----SISISNVCVEPCGTDAHASSL--
QPETSSLLLIEDRMNAEKAEFCNKSKQPGIAVSQQSRWAASKGTCNDRQ-VPSTGEKVG-
-----PNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 608)

DSLSDREKWTHPQSLCPENSG-ATTD-VPWITLNSSVQKVNEWFSRTGEMLT
SDSASARRHESNAEAAVVLEV--SNEVDGGFSSSRKTDLVTPDPHHTLMCKSGRDFSKPV
-EDNISDKIFGKSY-QRKGSRPHLNHVTE---IIGTFITEPQ-ITQ---EQPFT-NKLKR
KRS----TSLQPEDFIKKADSAGVQRTPDNINQGTDLMEP----NEQAVSTTSNCQENKI
AGSNLQKEKS---AHPTESLRKEPASTAGAKSISNSVSDLEVELNVHSS---KAPKK-NR
LRRKSSIRCAL---PLE-PISR-----NPSPPTCAELQIDSCGSSEETKKN-HSNQQPAG
HLREPQLIEDTEPA--ADAKK-NEPN-EHIRK--RRASDAFPEEKLMNKAGLLTSCSSPR
KSQG------PVNPSPQRTGT----EQ--LETRQMSDSAKELGDRVLGGEPSGKTTD---
RSEE-STSVSLVSDTD--------YDTQNSVSVLDAHT---------V-RYARTGSA-QC
MTQFVASENPKELVHGSN------NAGSGTEGLK---PPLRHALNLS--QEKVEMEDSEL
DTQYLQNTFQVSKRQSFALFSKPRSPQKDCA----HSVPSKELSPKVTAKGKQ-KE-RQG
QEEFEISHVQAV-AATVGLPVPCQ--EGKLAA-DTMC--DRGCRLCPSS-HYR-SGENGL
SATGKSGISQNSHFKQSVSPIRSSI-KTDNR-----------KPLTEGRFERHTSSTEMA
VGNENIL-----QSTVHTVSLNNRG-NACQEAGS--------------GSIHEVCSTGDS
FP---GQLGRNRGPKVNTVPPLDSMQPGVCQQSVPVSDKY-LEIK-------KQEG----
--EAVCADFSPCLFSD-HLEQSM--SGKVFQVCSETPDDLL-DDVEIQGH--TSFGEGDI
MERS---------AVFNGSILR---RESSRSPSPVTHA--SKSQSL-HRASRKLESSE--
ESDSTEDEDLPCFQHLLSR----------------------------ISNTP-ELTRCSS
AVTQRMPEKAEGTQAPWK--GSSS-DCNNEVIM-IEASQEHQFSEDPRCSGSMFSSQHSA
AQGSTANANSQDS--NFIPPSKQRSHQCGNEEAFLS--DKELISD-NEEMATCLEE---D
NDQEEDSIIP--DSEASGYESETNLSEDCS----QSDILTTQQRATMKYNLIKLQQEMAH
LEAVLEQRGNQPSGHSPSLLA-DPCA--LEDLPDLEPNMSG--A----------------
A---ILTSKNINENPVSQNLK--------SACDDKFQL---QHLEGPTSGDDESGMGRPS
PFKSPLA-GSRGSAHGCSRHLQKRNSPSQEELLQPAGSEA----SSEPHNSTGQSCLPR-
RELEG-TPYLGSGISLFSS-------R---DPESESPKEPAHIG----------TTPAST
SALK----IPQG--QVA--FRS-AA--AAGADK-----------------AVVGIVSKIK
--PELTSS-EERADRD

PF00533 // ENSGT00440000034289_0_Domain_3 (1997, 2070)

ISMVVSGLTPKEVMTVQKFAEKYRLTLTDAITEETTHVIIKTDA
EFVCERTLKYFLGIAGGKWIVSYSWVVRS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IQERRLLNVHEFEVKGDVVTGRNHQGPRRSR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

RE-KLFKGLQVYCCEPFT---NMPKDELERMLQLCGASVVKELPSLTHDT---
GAHLVVIVQPSAWT-------ED-SNCPDIGQLC----KARLVMWDWVLDSLSSYRCRDL
DAYLVQNITCD---SSEPQD-----SND--------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVPLSNLGIVRT-LRTKQQIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DAED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IKDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNAIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPDTD--------YGTQESISLLEVST---------L-GKAKTERN-KC
MSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGSEVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFSVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSPERA
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
LVQTVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIKED--TSFAANDI
KESS---------AVFSKSIQR---GELSRSPSPFTHT--HLAQGYQK-EAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEKDSHIRGQRNNSMFSKRPR
EHISVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGPHDLMEPSYLPR-
QDLDG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREN
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLSAARIQEVQSVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSTRF
SQLVEELLKIMAAFELD--TGMQVTNGFSFSKK-KN-NSCERLNE-EESIIQSVGYRNRV
RRLPQVEPGNA--TLK-DS-LSVQVSNLGIVRS-VKKNRQTQPRKKSVYIELDSDSSEET
VTKPGDC---SVRDRELLQTAPQEAGDEGKVR-S--AGEAACEFSE-GIRNIEHHQCSD-
D-------------LNPTENHATERH--PEKCQ----SISVSNVRVEPCGTDAHASSL--
QPETSSLLLIEDRMNAEKAEFCNKSKQPGIAVSQQSRWAASKETCNDRQ-VPSTGEKVG-
-----PNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 608)

DSLSDRKKWTHPQSLCPENSG-PATD-VSWITLNSSIQKVNEWFSRTGEMLT
SDSASAGRHESNAEAAVVLEV--SNEVDGGFSSSRKTDLAAPDPHHTLMCKSGRDFSKPV
-ENNINDKIFGKSY-QRKGSRPHLNHVTE---IIGTFITEPQ-ITQ---EQPFT-NKLKR
KRR----TSLQPEDFIKKADSAGVQRTPDNTNQGAGPMEP----HEQAVSTTSNCQENTI
EGSNLQKERN---ACPTESLRKEPASTAGAKSKSNSVSDLEVELNVRSS---KAPKK-NR
LRKKSSTRCVL---PLE-PISR-----NPSPPTCAELEIDSCGSTEETKKN-SSNQQPAR
HLREPQLIEDTEPA--ADAKK-NEPN-EHIRK--RRASDAFPEEKLMNKAGLLTSCSSPR
KSQG------PVNPNPQKTGT----EQ--VETRQIPDSAKELRDQVLRGEPSGKTTD---
RSEE-STSVSLVPDTD--------YDTQNSVSVLEANT---------V-RYARTGSA-QC
MTQFVASENPKELVHGSN------NAGSGTECLK---PPLRHELNHS--QEKVEMEDSEL
DTQYLQNTFQVSKRQSFALFSKPRSPQKDCA------------SPKVTAKGKQ-KE-RQG
QEEFEISHVQAV-AATVGLPVPCQ--EGKLAA-DTMC--DRGSRLCPSS-HYR-SGENGL
SATGKSGISQNSHFKQSVSPTRSSI-KIDNR-----------KPLTEGRFEKHTSSTEKA
VGNENIL-----QSTVHTISLNNRG-NACQEASS--------------GSIHEVCSTGDS
FP---GQLGRNRGPKVNTVLLLDSTQPGVCQQSVPVSDKY-LEIK-------KQEG----
--EAVCADFSPCLFSD-HLEQSMR-SGKVFQVCSETPDDLL-DDVEIQGH--TSFGEGDV
MERS---------AVFNGSILR---RESSRSPSPVTHA--SKSRSL-PRASRKLESSE--
ESDSTEDEDLPCFQHLLSR----------------------------ISNTP-ELNRCSS
AVTQPMPEKAEGTQAPWK--GSIS-DCNNEVIV-IEASQEHQLSEDPRCSGSMFSSQHSA
AQGSTAIANSQDP--NFNPPSKPRSHQSGNEEAFLS--DKELISD-NEEMATCLEE---D
NDQEEDSIVP--DSEASGYESETNLSEDCS----QGDILTTQQRATMKYNLIKLQQEMAH
LEAVLEQRGNQPSGHSPSLLA-DPCA--LEDLPDLEPNMSG--A----------------
A---VLTSKNINENPVSQNLK--------SACDDKFQP---QHREGPTGGDDESGMGRPS
PFQSLLA-GSRGSAHGRSRCLQKRRSPSQEELLQPAGSET----SSEPHNSTGRSCLPR-
QDLEG-TPYLESGISLFSS-------R---DPESESPKEPAHIG----------TTPAST
SALK----ISQG--QVAESFRS-AA--AAGADK-----------------AVAGIVSKIK
--PELTSS-EERADRDIAMVVSGLTPNE

PF00533 // ENSGT00440000034289_0_Domain_3 (2009, 2070)

VMIVRKFAEKYRLTLTDAITEETTHVIIKTDA
EFVCERTLKYFLGIAGGKWIVSYSWVVRS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IQERKLLNVHEFEVKGDVVTGRNHQGPRRSR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

RE-KLFKGLQVYCCEPFT---NMPKDELERMLQLCGASVVKELPSLTHDT---
GAHAVVIVQPSAWT-------ED-SNCPDIGQLC----KARLVMWDWVLDSLSSYRCRDL
DAYLVQNITCVPD-SSEPQD-----SND--------------

MR---ALGWHKEKFC---F--VLFCSPYLEEMDLSAVQIEEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPISTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSTRF
SQLVEELLKITDAFELD--TGIQYANGYSISKLK---NSSEPLNE-EASIIQSVGYRNRG
KRLRQIESGNA--TLK-DS-LSVQLSNLGIVRS-TKKNHQTQPRNKSVYIELESDSSEET
VSKPDDC---SVRDQELLQTTSLGAGDEVSLD-S--STRAACEFSE-DVTNIDLHQCSNK
D-------------LDPIENHATGRY--PEKCQ----DISVSNLHVEPCGTDIHASSL--
QHENSSLLLTEDRMNVEKAEFYNKSKQSGLARSQQNRWAESKETCNDRQ-IPSTEKKVD-
-----PNT

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 607)

DSFCGRKKWKNQKSLCPENSR-ATQD-VPWMTLNSSIQKVNEWFSKTGEMLT
CDGTSDRRHESNAGAAVVLEV--SDEVDGCSSSSKEMDLVASDPHNALKCKSESDLSKPV
-ENNIRDKIFGKTY-QRKGSLPHLNHVTE---IIGTFIAEPQ-ITQ---EHPFT-NKLKR
KRR---TTCLHPEDFIKKADLTVTQKTSKNVNQGTDQMEP----DGLVMGITSNGQENET
QGNNLQKEKN---ANPVKSLEKGSVSTTKAKTISNSISDLELELNVHNS---QAPKK-SR
LRRKSSTRCVL---ALEP-VSR-----NPSPPACTEFQIDSCSSSEETEKNN-SNPTPVK
NIRKPQLTEDTEPA--ADSKKNKEPN-EQRRK--RRASDPFPEEK--FMPGLLTNCPSSS
KPQGPA------NPSPQRKEV---EK---LETSQMSDSTKDLRDLLLDGEQ-GLPTE---
RSEE-STSVSLVPDTD--------YDTQNSVSLLEANA---------V-RYAKTVSS-QC
MTQFVASDNPNEL-VHGSK-----DAGSGTECFK---HPLRHELSHI-QE-TIEMEESEL
DTQYLQNTFQASKRQSFTLFSKPRDPQEECVTACASSVSLRDMSPKVTSEGEQ-QEESRG
HEEAEISHIQAG-PATVGVPLPRQ--EGD-PGADTM--HAAVCSLCPSS-QYR-SNE---
----------NSHPKQSASPIMSSI-KTGHG-----------KTLSEEQSEKHTLSNEKA
MGNETFV-----QSTMHTISQNH-RKNGCQEANSG--------------SINEVPSSGEN
FQ---GQLGRNRRTKLNTVLPLGLMQPGVCKHSFPVSDYK-YLEI-------KKQ--E--
-GENVGAHFSSCLFSD-KLEQPVG-SGNVFQICSETPDDLL-DDVEIQEN--TSFGEVDI
MEKS---------AVFNGSVQR---RELSRSPSPLTHA--SLARNL-QRRSRKLESSE--
DSGSCEDEDLPCFQHLL-G---------------------------QVSKTPEPSS----
VVTQPLSEKAEGTQVPWK--SSVG-DSDNEVIL-IEASQEHHPSEDAKYSGSMFSSQPSA
VQGSTANTSSQDPL--FNL-SKQKSHQSEDEEDFLS--DKELISD-DEEMGTCLEE---D
NDQEEDIIIPDSAEAASGYESETNLSEDCS----QSDILTTQQRATMKDNLIKLQQEMAH
LEAVLEQQGDQPSVHSSSLTA-EPCA--PEDLPNAEQNLSGTA-----------------
----ILTSKNINENPVSRNPA--------CVSADKFQP---QPPDSSSSENKESREGRPS
LFKSPLA-GSRCSAHSRSGSLQNRNCPSQEELLWTVEAG---------------------
-KSEG-TPYLESGISLFSN----------RDPESESPKEPAYVC----------TTPAST
SART----ISQY--QVSDSFES-PA--ATHAH--T---------------AVIETVSKKK
--PELTSS-KGRANK

PF00533 // ENSGT00440000034289_0_Domain_3 (1996, 2070)

GISMVVSGLTPKEVMIVQKFAEKYRLTLTDAITEETTHVIMKTDA
ELVCERTLKYFLGIAGGKWIVSYSWVIQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IQERKLLSVHEFEVRGDVVTGRNHQGPKRSR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

-EKLFKGLTICCCEPFT---NMPKDELEKMLQLCGASVVKELSSLTPDT---
GVHPIVIVQPSAWT-------E-ENGCPEIDQLC----GAHLVMWDWVLDSISVYRCRDL
DAYLVQNITHGHD-SSEPQD-----PND--------------

-------------------------------MDLSADHVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSRK-EN-NSPEHLKE-EVSIIQSMGYRNRA
KRLWQSEPENP--TLQETS-LTVKLSNLGIVRS-LRTKQQTQSQNKSIYIELGSDSSEDT
VNKASYL---SVGDHELLEITPQEAKAKTNLN-P--AKTAACE---KDITNTEHHQLSIK
D-------------LITTQEHAAETH--PEKYQ----GISVSDFHVEPCGTDTHASSL--
QHENSSLLLTENRLNVEKAEFCNKSKQPVLVKSQQSRWAESKGTCKDRQ-IPSTGKKIV-
-----LNT

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLYGRKELCKQKPACSDSPG-DSQD-VPWVTLNNSIQKVNDWFSRSDEILT
SDDSCDGGSESNNEVAGAVEI--PNNVDGYSGSSEKIDLMASDPHGTLIH--ERVHSKPV
-EGNIEDKIFGKTY-RRKSSLPNFSHIAED-LIIGAFTVEPQ-KTQ---EQPIT-NKLKC
KRRG--TSGLQPEDFIKKGDLTIVPKTPEKMIERTDQTEQ----KHHGINITSDGHENKT
KCGDVQKEQN---ANPTESLENESVFRTKAEPINTSISNMELELNIRSS---KAP-K-NR
LKRKSATRKIP---ELELVVSR-----NPSPPNHTELLIDSSSSNEEMKKK-HSSQMPVR
QSQKLQLMGDKEPT--AGAKKSNKTY-EQINK--RLASDAFPELNFTNTPGYFTNCSSK-
-PEE------FVHPSLQRE------EN--LGTIQVLNTTKDPKDLMLRGGK-ALQME---
RSVE-NTNISLVPDTD--------YSTQDSISLLEAKT---------P-EKAKTAPN-PR
VSLCAAIENPKELIHRDFK-----DNKNNTEGFQ---GLLGHDVNYVIQETRGEMEDSEL
DTQYLQNTFKVSKRQTFALFSNPGNPQKECATVFAHSGSLKDQSPRDPLKCRQ-KEDSWG
KSESKSQHVQAV-CTTVHFPVAGQ--KDKTPGDDAKCSAKEVTRVCQSL-QLR-GHKTEL
VFADKQGVSEKPNLIPSLFPIKSSV-KTVCK-----------KSPS-EKFEEPVMSPERT
LESESII-----QSAVSTISQNDIQESTFKEVNSSSVNEVGSSTNEVGSSINEVGSSGEN
IQ---AEPGRNREPKLRALLRLGLMQPEVYKQSLPVSNCH-HPEI-------KRQGENED
MLQAVKADFSPCLISD-NLEQPMG-SCHASQVCSETPDNLL-NDDEIKEN--SHFAESDI
KERS---------AVFSESVQK---GEFRGSPGPFTHT--HLAQGH-QRGAGKLESE---
ETVSSEDEELPCFQQLLFG---------------------------KVTDTLSPSTRWNT
IATEGLSKETEENLESLK--SGLN-DGSGQGTS-AKVSQEHHLNEEVRCSGSLFSSQYSA
MEDLTTNTNTQDPFLMFERPSKQVYQSE-SE-EVLS--DKEFVSD-DEERETGLEE---D
SCQEEQSVDSDLGEAASDHVSETSLSEDCVGLSSQSDILTTQQRDTMQDNLLKLQQEMAE
LEAVLEQHGSQPSHSSASLTA-DSRG--PEHLLNLEQDTSE--R----------------
A---ILTSEKSRDYSRSQNPE--------SLSADKFPV----SLDSSTNKNKEPGMERSS
PSKSQLP-GNRWYMHSS-RSLQDRNCPSQKKCINVADMQEQQLAKCEAQDLM-GSYLPR-
QDQEG-TPYLKSGISLFSH-------EPESDPSEDRAPEPAHVH----------SMPPTA
SALK----LSQF--RVEESTKN-PA--AAHITN-TTGCD-----------LREESVSKEK
--PEVLSS-TERSNKRLSMVASG

PF00533 // ENSGT00440000034289_0_Domain_3 (2004, 2070)

LTPKELMLVQKFARKHHVTLTNLITEETTHVIMKTDP
EFVCERTLKYFLGIAGGKWVVSYFWVIQSIKERKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----RDKKVKPF------S--P---VLTKNQLEWMVQLCGASVVKEPSSFTPGQ---
GIHPVVVVQPDAWT-------ED-AGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLVA---QSCC-----------------------------

-------------------------------MDFSVITIGQVQNVLSA

PF11789 // ENSGT00440000034289_0_Domain_0 (49, 105)

MQKNLECPICLD
VVQEPVSTKCDHTFCRFCMFKL---------INKKKKGVVECPLCKTEVTKRSLKENSRF
KQLIEGLLEAIHAFELD--TGVKFLKNHHFPKTSTEAT-AESLCK-ESSVIQSKGFRNRR
KSAKGNEQENF--TL-EAS-VNIHLTDAK--MCRPRNKPQKSDSQKGIYIEFGSESSEEF
FKQASKT---GFEDKGTVQ--------KLESAEK--TNENSCNAQPDKLCVKEITLPDII
GESDFSKECLSKKSTRSITECAKADQVNVTECQSSPLKVLAADLLPEQCDRTGDASPT--
VNEDTSFFKNIEEMEEQQAQYSSENQEFDLEDSSESRLDKSREMDTDVQ-SVEAVEGYE-
-----PENDSSYDKEH-PLEELPQPETLHSASLNKVSKKRLKQSIQKVNEWFSKSNEVLS
SSSSLDESAASADVSGEG----DLCSSDKESCISAKTDPVADSMEIA-AVEGKKRWSKQT
-AENIKDKIFGKTY-KRGRKSNPPSTLRD---ILPTKQKADVA-PDKCLNDFSK-DRLKR
KRKT--ACVLQPEDFIKKKDTEEADGDPQSVNGGLGEAEK-KRCDESVAV-NESHLSQNR
AKNALTEP----------EEGGESTWKKATEKVTTKHCDGEPEMYNCDQKSSKKRSS-AA
KRCRHSSRTMC---ALQLVVDR-----GSVFPDAAEPQIDSFPSSGEPRQA-DSEQNPVR
RSRRLQLLSEEVTK--GTRKG--VKGARKTNS--GSGRSISRDQR--NVATQSAECQDLC
EPQD------ELSYRPVTNME---GGDLEANEMQVT--LKNLYHTEETGKS-LFRPS---
--CLPSNCGSTVPDT----------DSQDS-KILGSPLLLQLPSMSAK-QTASHQTEE-G
TESPTAFPPECG-----------HDSQNVPGDFKTEKLPMAKNV----LELTKEAEESDL
DTQYLRNIFRHSKRSSFSLFQAP---RQARAVQEPPSE-------TLNLSCAA-QVENKA
SKQLQTESLQEERTAAQNLSRLSE--KKRLKPCESAHV-------DPVP-CFAVST----
-GEHRDGISQAAEEGALTPA-RTGTAQTEHKNGLLQEEQVNEKPVSD------------E
IGIESELRQNPTERDGSQSDQSNTEKQDSRQNDLN--------------TGQENSFSSES
NQAGKTEVVDCTEPILH-FQSTSTICSATCQQSPAEFSCEVTRTKSSKRERKLVKGNEEE
AAQTVSTAISKLTAVE-ALEEPVR-ENHDLTRLSETPNALLCSDTDIEGN--TSLCETDR
KEQS---------AVFVKSDN-ALGKELHKRNASSKPR-SRGVRKS-RRRVQKLPSSD--
-EESCEDEDLPCFRTLIFS---------------------------KSASTPLQTDKQMA
SVAESLV--ADPNVLPHS--VSNDGNIVQKVPEAALSNVCVSPSQESECSVNLFSSQSNM
SEESLNGAQEPNKHLPQAH------VVNDSKETSQN--SSGGLKET------------KD
ECQGVPDMGANLGEA-SGYDSEISLVEDSCGPFSQGEILTTQQKNAMQNNLKKLQQEMAA
LEAVLKQNGSQNCEVLPVHRELPHSS--TEGAFEMDQMRKENNR----------------
S-----------------------------------------------------------
------------------------------------------------------------
-------------------------MEQKSGTRQNSASVSSDLFGNE-------SPDNSA
SSVR----LFTP--QTAEATGG-PV--LAQNTD-KSCGLGHKLKRSECFPAPVLHNATGK
--ENTTNP-VVTKRKK

PF00533 // ENSGT00440000034289_0_Domain_3 (1997, 2069)

MSIVVSGLHHSEHLVVQKFVKKTQSTLSNHITEGTTHVIMKTDE
ELVCERILKYFLGIAGGTWVVNFTGIIQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2110)

SFKEGRILDEEKFEVRGDVINGRNHQGPKRAR
EA-----LT

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2212)

GKIFKDFEICCCGPFT---DMTTGHLEWMVELCGASVVKQPDLFTPTA---
NSAAVVVVQPDAWK-------EN-VDYRAMQQQS----SVAVVTREWVLDSVACYQCQEL
SAYLVS------------------------------------

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--------------HSHTTSLQNRNCPSQEDLIKIVDVEEQELKKSEPPDLMEQSYLPR-
QDLEG-TPYLESGISLFSK-------DPDSDPPEDKDPEAVHVC----------NVPAST
SALK----LCQF--QVGQSANS-PA--VAHTTS-TAGYN-----------AREESMSREK
--PEFTSP-TERTKQRISMVV

PF00533 // ENSGT00440000034289_0_Domain_3 (2002, 2070)

SGLTPKELMLVHKFAKKHHIILSNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

IKERKILDEHDFEVRGDVVNGRNHQGPKRAR
ES-----QG

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2211)

RKIFRGLKICCYGPFT---NMPTDQLEWMVQLCGASVVKEIASLTLDT---
GAQPIVVIQPDAWT-------ED-NGFHAIEQMC----KAPVVTREWVLDSVALYQCQEL
DTYLIPQISPSHC-----------------------------

---------------------------------LCADRVEEVQNVLNAMQKI

PF02891 // ENSGT00440000034289_0_Domain_0 (53, 108)

LECPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLPFTNSYSFSKK-EN-NSPEHLNE-EVSMIQSLGFRNRT
LRFRQSEPENP--TLQETS-LSAQLSNLGIVRS-RRTKQQVQSQKKSVYIELGSDSSEDS
ANKGRYY---SVRDHELLQITPQGARAEARLN-P--AKKAACEFSG-DITNIEHHQSSNK
D-------------LPTTEKHAAEKH--TEKYQ----GISVSNLHVEPCGTDTHASSL--
QHENSSLLLTKDRMNVEKAEFCNESKQPGLARSQQSRWAESKETCNDRQ-TPSTENRVI-
-----LDADPLNGEKEL-----PRSDHPR-DSQD-VPWITRSSSIQKVNEWFSRRDEILT
SDGSHNGKSESNAEVAGAVEV--ANEVDGYSGSPGKITLLAHDPHGVLTCESERVHSKPV
-ESNIEDKIFGRTY-RRKASLPNLSHITEN-LIVGASAIEPQ-ITQ---ACPLT-SKLKR
KRRS--TSGLHPEDFIKKVDLAVVQKTPVEIIKGTDRIEQ----NGHEMNITNNDHENET
KGDCVQKEKN---ANLTESLEKESAFTSKAEPISSSISNLELELNVHSS---KAPKK-NR
LKRKSSTRPIH---ALELVVNK-----NPSPSNHTELQIDSCSSSEEVKEK-NSDQIPVR
HSKKLQLMEGKEPA--TGAKKSNKSD-EQINK--KLASDAFLELNLTNIPGVVTNGLSSN
KLQE------FVDPNLQREET---EEN--LGTIQMSNSTKDLKDLTLSGGR-SVQTD---
RPKE-STNIVLVPETD--------YGTQDSVSLLEPDT---------P-RKAKTAPN-QC
GDLCAAVKNPKELIGGCSK-----DTRNDREGFK---DLLRCEVSHT-QETSMEVEESEL
DTQDLQNTFKVSKRQSFALFSNP---EKECATVYAHSQSLRKQSPKVTLESGQ-KEENQG
KKESKIKHVQAV-HTAVGFPVVCE--KDKKPGEYAKYSIKGTSRHGPSS-QFR-GNETEL
TITDKYGISQNPYHIPSISPIRSFV-KTVSK-----------KNLSEEKFEEHSVSPGRA
MGNENIP-----S-TVSPISLSNIRESAFKESSSSSTNEG-------GSSINEVGSSGEN
IH---AELDINKGSKLTAMLRLGLMQPEVYKPSLPVSNCK-HPEV-------KRPGDNEG
VVQAVNADLPPRQISD-NLEQPMG-SSPVSQVGSETPDDLL-TDDEIKEN--SGFDESGI
KERS---------AVFSKDVQK---EEFRRSPSPLAH--THLTRSR-QRRARKLESSE--
EDMSSEDEELPCFQHLLFG---------------------------KVIKIPSPSTSVAT
KSLSN---KTEENLG-LK--SSLS-NCSNQVML-TKASQEHHLSEEARCSRSLFSSQCSA
SEDLTANTNTQGPVLIFDPPSQQMRYQPENQE-VLS--DKELISD-DDDDDDERETGLEE
ENQEEQSADSDLDEAAFEYESETNLSEDYSGLSSQSDILTTQQRDTMQDNLIKIKQEIDQ
VEAVLEQQGSQPSDRSPSC------A--SEDLLNPRQNTP-ET-----------------
V---VLTSEKSDEYLVSQNPE--------SLSADKFQD---SLDSSIRYKNKEPGMESS-
S-TPQLL-DDRWYVHCHSQSPQNRNHPSQKELIESVDVEEPQLTKSETQDLMEPSYLPR-
QDPEG-SPCLQSGISLFSD-------DPESDPAEDRAPESAHVC----------SMPAST
SALK----LPQF--QVESAKS--PA--ATHTAN-AAGYD-----------VREESASREK
--PEVTSS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-AKTGNKRISMVASGLTPKELTRVHKFARKHHITLTDLITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWIVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKILDERDFEVRGDVINGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFKGLEICCYGPFT---NMPTGQLEWMVQLCGASVVKEPSLFTLGKGMQ
GTHPIVVMEPDAWT-------DD-SGLRVIGQMC----EVPMVTREWVLDSVALYQCQEL
DTYLIPQGPGAAADSCQPCV----------------------

----------------------------------------------------------

PF00097 // ENSGT00440000034289_0_Domain_0 (59, 105)

LE
LLREPVSTNCDHIFCKFCMLKL---------LNQ-KKGTSQCPLCKNNITKRSLQESTRF
SKLVEELLKTIHAFELD--TGLQFENSYNFLKK-QN-NSPEHVKE-EVSIIQSMGYRNRA
KALRQNKPESP--ALQENNP-DAQPANPGTVMS-LRTK---QKKKKAVYIELGSDSSEDT
AHQASYY---SVVDPDLIEITPQGARPEARLD-P--TKKAACEFSE-DLPNVDYRPSRNK
D-------------LNTHKKQATEKH--PEKCQ----DIPVSNPHVEPCGTNTLANSL--
QRENYSLLLTKDRLNVEKAGFCNESKQPGLARSQHNRWAESKETCNDKP-TPSTEKKVD-
-----KNADPVHGRKGVPKQKPPCHGSPR-KSHD-VPWKTRKSSIWKVNEWFSKSDGLGD
SH---DERPESDADVAGAFVP--DE-RE-SSSSP---EKDVSDPHXXXXXKSERVLSKPV
-ERHLGDKIFGKTY-RRKSSLLNSSHVTED-LNGGAAAL--Q-IAQ---EHPSY-PVKLK
TQKI--LPSSHPEDFIKKADLAVE-----KINQGTDQTRP----KGQVEHTPDGGHGHGT
KGGDCVQKES---ADLAESSAKESAFRTVAEPLSSRKSGMELEPTVFNA---KA-QK-NR
LRRKPSARHIH---PLEL-VNR-----QPSPTRHTELQISSWPSSEELKKE-ESEPKPVR
RSRNLQLTKDQEMA--IGAKKNDKPN-EERGK--KHAPDTFPERNLTDTTDLITTCSFSG
NLQA------SVCPSLPGANL---KEK--LGTVQVSNGTRDPKGEVLGRAR-GLQTA---
RSVE-STSVSLIPDAD--------DGPQGTISIMEAGN---------R-GEAQTAPG-EC
ARQCAATENPNGSVQGLSK-----DTRNNTEGSE---DLLTHDVNHL-QETCTEMEESEL
DIQSLQNTFKVSKRQSFALSSNP---EKECASLGA-------RPPNIALECGD-RGT-EE
NKESAVRPVQAV-PATVGGAGGSP--TEQQPRDYTKSHLQGVSRLGQAA-PFR-GSESDP
STSVEHGIVQTSERAPPLAPIRSSV-NSERK----------------ERLEDHAESLERA
SENESII-----PSTVSTISQNTPRENAFKGTSSSS--------------LNEVGSSSEN
IQ---AELARNREPKLDAVLRLGLVQPEVCKESLPMRKCK-HSEV-------KRQKGNGG
LVPAVHPDFSRYLMSH-NPEQPME-DND-PQICSETPEDLL-DDSEINKN--SHLVQSDI
RERS---------AVFSKDNQR---RDFRRSPGPTSH--LGLSWGH-PRGAEELESLE--
ENGTSEEEELPSFQHLLFG---------------------------KVTSASFQSTRRGA
DAMGCLSKNTWESSGSMQ--NIVK-DDTNQPTL-VQASHEH-HREKPRCSGSLFS-PCST
SAGLTANTNTRGLSL-FGSSSKQVRHQFENQEAVLS--DEELVSG-DDEKGTHH------
--SDDQSVNSDIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQRDAMQGDLIKLQQEMAE
LEAVLEQHGSQPSSSCPSP------V--DKDLCHP------GG-----------------
T---TLTSEKSNEHPVSGNTE--------SLSAAKLQA---SPD---ARENRDPGKERSS
S-KLQVL-DNRWDVYSS--RLQNGNCLAQGEHSEVVDVQMQQPEKCEARGLMDQSSLPK-
QDPEG-SPGLDSGVSLFSG-------APEA-----RAPDAAHGG----------SRPPSS
SALN----VPQL--QVAQLTND-PSAAHTTTKS-AARNN-----------VREGSVSTEK
--

PF00533 // ENSGT00440000034289_0_Domain_3 (1983, 2070)

PGTP----EGAGKRVSMVASGLTQKELMLVHKFARKYNCTLTNEITEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYLWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

MKGRKRLHEXXXXXXXXXXXXXXXXXXXXXX
XX-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

XXXXIFEGLEVCCYGPFI---NMSTDQLEWMVRLCGASVVKALSSFTLGT---
GTHPIVVVQPDAWS-------ED-SGFQAIWQLC----DASVVTREWVLDSIALYQRQEL
DTYLILQVPQDHY-----------------------------

-------------------------------MDLCADRVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSKK-EN-NSPEHLNE-EVSIIQSLGYRNRA
KRLRQSELENS--TQE-TR-LSVQLSNLGIVRS-LRTKQQIHPQNKFVYIELGSDSSEDT
VNKASSC---SVGDHELLQIIPQGARAEASLN-P--AKKDACEFSE-DITNIEHRKSSNN
D-------------LTTTEKHAAEKH--PEKYQ----GSSVSNLHVEPCGTNAHASSL--
QHENS-LLYTKDRMNVEKTDFCNKSKQPGLARSQQNRWVETKETCNDMQ-TSSTEKKVV-
-----LNADPLNGRIELNKQKPPCSDSPR-DSQD-ISWITRNSSIQKVNEWFSRRDEILT
SDVSPDGRSESN-----VVEV--PNEVDGYSGASEKIALKANDPRGALMC--ERVHSKLV
-ESNIEDKIFGKTY-RRKASLPNLSHITEN-LITGASAIEPQMITQ---EYPLT-NKLKR
KRRT--TSGLHPEDFIKKIDLAVVQKTPENIIEETDQIEQ----NGHVMNSTNNGHENET
KGDYVQKKKN---TNPTESLEKESTFKTKAEPICSSISNMELELNIHSS---KAVKK-NR
LRRKSSTRHIH---ALELVVNR-----NPSPPNHTELQIDSCSSSEELKEK-NSDQMPVR
HSKKLQFIEDKESS--TGAKKNNKPN-ETINK--RLASDAFPELNITNIPGFFTNGSSSN
KLQE------FVNPSLQREEI---KEN--LGTIQVSNSTKDPKILIFGEGR-GSQTD---
RSTE-STSILLVPETD--------YGTQDSISLLEPDI---------P-ERVKTAPN-HH
----AAIKNPRELIXXXXX-----XXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X--XXX
XXXXXXXXXXXX-XXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX-XXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-----------XXXXXXXXXXXXXXXXXX
XXNETII-----QSTVGAISQNNIRESTFKEGSSSSIYEAGSSTNELGSSVNEVGSSGEN
IQ---AELSRNRGPKLNAVLQLGLMQPEVYKQSLPLSNCK-HPEI-------KRQGENEG
VVQAVNADVSLRQISD-NLEQPMG-NSNASQVCSETPDDLL-NDDKIKEN--IGFDESGI
KERS---------AVFSKSVQK---GEFKRSPSPLAHT--SLSQGR-RRGARKLESSE--
EDVSSEDEELPCFQHLLFG---------------------------KVTKVPSSSTRHNA
VATEGLSKKTEENLVSLK--NSLN-DSSNRIAS-AKASQEHHLSEEARCSSSLFSSQHSA
SEDLIANPNTQDPFLMFDPPSKQVRHQSENQ-EVLS--DKELVSD-DDERETGPEE---Y
N-QEEQSVDSNLDEAASEYENETSLSGECSRLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPNMSP-PLIA-DSCA--PEELLNPEQNTSE--K----------------
A---VLTSEKSSAYPIRQNPE--------SLSANKFQE----SLGRSTNKNREPGVERSS
PSKSQLL-DDRWYVHSHSQSLQNRNCPSQKELDKVAKVLEQQLIKPEAQGIM-SSYLPQ-
LDLEG-TPYLESGVSLFSD-------DPQSDPSEDRAPEPAYIC----------SMPAST
SALK----LPQF--QVQESAKS-PA--AAHT-N-TVGYN-----------VREESVS-KK
--PEVISS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-TKRVNKRISMVASGLTHKEFMLVHKFARKHHITLTNLITEETTHVIMKTDT
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERTILDEHDFEVRGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFRGLEICCYGPFT---NMPTDQLEWIVQLCGASVVKEPSSFTLGE---
DTHPVVVVQPDAWT-------ED-GGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
NTYLIPQISSCC------------------------------

-------------------------------MDLSALRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLEYANSYNFAKK-EN-NSPEHLKD-EVSIIQSTGYRSRA
KRLLQSEPENP--SLQETG-LSVQLSNLGTVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDEISLD-SAK--KAACEFSETDVTNTEHHQPSNN
D-------------LNTTEKRATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKNKQPGLARSQHNRWAGSKETCNDRR-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLCERNEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLG
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV
ESN-IEDKIFGKTY-RRKASLPSLSHVTEN-LIIGAFVTEPQ-IIQ---ERPLT-NKLKR
KRRA--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSGHENKT
KGDSIQNEKN---PNPIESLEKESAFKTKAEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKKYNQMPVR
HSRNLQLMEDKEPA--TGAKKSNKPN-EQTSK--RHDSDTFPELKLTNAPGSFTNCSNTS
ELKE------FVNPSLPREEK---EEK--LETVKVSNNAEDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKGLIHGCSK----DT-RNDTEGFK---YPLGHEVNHS-RETSIEMEESEL
DAQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTFECEQ-KEENQG
KNESNIKPVQTV-NITAGFPVVCQ--KDK-PVDYAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPIKS-FVKTKCK-----K------NLLEENFEEHSMSPERE
MGNEN-I-----PSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCK-HPEIKK----QEY----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHASQVCSETPDDLL-DDGEIKED--TSFAKNDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DCSNQVI-LAKTSQEHHLSEETKCSASLFSSQCSE
LEDLTANTNTQDPFLIG--SSKQMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---N
-NQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIS-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPISQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSL
ESRRSRL-QTETLLKK--------------------------------KNITLSLLLPRL
ECNEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------NIPSST
SALK----VPQL--KVAESAQS-PA--AAHTTN-TAGYH-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGLTPEEFVRQH------FLI--LFSTSNPLSVFHSADA
EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKEGKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

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--------------MPS-TPVQT-LAKIGEG-----GNQLQSQKLTTERRAS-PGIGENT
SGSSRSL-----SG--NGRSPSILRNCNIQGSSLSLV--------------NETCSNRDH
FQKAESTGAEHNGLTLSTQPESIQPCPAICQPSLPQSSHV-ETKRSS-IEQKQLNNDIEE
AMDISSIGVPQCLVSKENLEQCTEEGHCVFELSSETPEGLL-DPAIKSKEGPSDLLETDR
EDISGVSSKMDRPSLVGKDLGN---N--DSGNSMLKRK--HFVLAH-RKPVRKLPSSE--
EDESSEEEELPSFQARLFG---------------------------TSSQAL----KNNE
TSV---------EMLGLQ--NSSR-SH------LSSKAEDVSLSQESECSVNLFSSQSHA
SEDSCSKACDTRHLTPVSGSVEKPPIPSKNKE-------DIQPSG-DASRKDVQPK---D
EQPRYENSESNLGEECMGYDSEASHLGDSSGLSSQSEILTTQQRDAMQNDLKKLQHEMVI
IEAALKQGTQ-HDAPEEWLEL-DKED--------PILSIAGA------------------
---LGYSRTSRDTLPLSSSRRRSSTKATKAVLVPCPGL----KPDCAGS-----------
-RKSVST-KNPWSCEATTRSITL----------------------QGPGRS---------
--------------------------------------QQAPT-----------------
GPVR----S-----QQAPTGLV-------HSAE----------------------ARQGQ
QPP--TIC-SETHKKNMSLVA

PF00533 // ENSGT00440000034289_0_Domain_3 (2002, 2070)

SGLNQGELRLVQQFVRKTKSSWSNKMTEETTHVIMKTDE
DRVCERTLKYFLGIAAQKWVVSYQWIEQSLQAERLLNEEDFEVRGDVINGRNHQGPKRSR
ES-----PPGKLFQGLEICCYGPFT---DMLPEQLEWMVELCGASLVKQPHLFAHPT---
NSSAVIVVQPDVWG-------ED-TACQGLPPQC----NATVVLREWVLDSVASYQRQPF
DGYTIH------------------------------------

-------------------------------MDLSTVRVEEVRNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LDQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNSVTRRSLQENTRF
SQLVEELLKVIHAFELD--SGLQVANSYNFSKK-ES-NSPEHGKEEEISIIQSMGYRNRS
KRLHWGEPENP--GLQETS-LGVQLSDLGIMKS-LRTKQQVQPRNKPVYIRLGSDSSGDT
VNEEN--------HLSVLLLTPQGTRSEASLD-SVKQGNAACEVSEKGAADPDRPRPST-
N-------------ASTVEKRAAERR--PEKHQ----GGRVPDLRVEPCGTETRASSL--
QRENSHLLLTEDRMDVEKAEFCNKSKQPGFARSQLSRWADGTESSDDGQ-MPGTEQKAE-
-----WGTE

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

PLCVRGE-KEQKAPDPERLR-EAQD-VPWVTLNSSIQKVNEWFSRSDEVVT
SDSACDRESQADTEEAGALRD--PEVRDGFSGSLEKIALLASNPQSALLSTSEQVCPKAG
-RKDTKDKVFRKTY-QRKPGFPSSIRVAEN-RTVEALVVQPQ-VTQ---GCPPT-NTLKR
KRRT--MSCLHPEDFIKRADLAVAPKTPEKINQGTEQMQE----SGQVAGTPNNSHEGDP
EGGSLQRQGT---PSPAQSLGKESAARAR-ELQSHSRSSRGLESCVCHS---EPPKE-SR
LR--SSAKRVP----------------HPGPPDCTKLQSDNCTGTEGAKEK-SSP-----
--RKLHLVGRVEAS--IGTKESKKPG-DHVRK--RRAEEAIPAH-----TPSSA--NRSG
PEKE------FVNPSPLR------EEN--PEMVQVSDSTRGPKDQVLSGER-GLQTE---
RSAE-STSISLVPDTD--------YSTEDSFSLLEASS---------L-RKTRRVP--QP
VAQYVAVAKPKELLPARSE-----DSGDGAEGFN---DPLRRDVSHA-REANVEMEDSEL
DTQCLQNTFQASNRQSFALFSNPGNPEKRSTAVFSHSEALKKQSPEVTPECEQ-TEDRQG
EKVSEIGRVQAA-NAAAGGLVVSQ--NG-QPGAGAQCGVTGVSRLHPSS-QVG-GDKTEL
ISADKLRIPQSPCHRPSVSPVRTLV-KSTCK-----------KTPSTS--------PQEA
AGSGSTL-----ESMASTGGHTNSRALAAKEAISG----T-------GSSTNEVASSGEH
MQ---AEPGRSRGPTLNAVLRSGLMQPEVQEQTLPARGCD-WPHI-------PRRGVSGV
VAGAVHADFSPCLVLD-SVEQPVG-GSPASQICSETPDDLL-DSEDRKED--TSFAEGDI
KETS---------AVFSRSVQR---RQFNRSPSPLTH--AALTRGR-QRGARKLESSE--
ENVSSEDEELPCFQHLIFG---------------------------KGHATP-QPTRPGP
DATERVCLGTEENLESPR--GGLQ-GCANEP-----VSPEPQLGEDIRCSGSLFSSQYSV
PEDSAADRISQDPFLM-CPPAELKGHPSGAQGASLS--GREVVSD---------------
------------GETASGYESETNPSDGCSGLSSQSSILTTQQRNTIQDNLLKLQQEMAH
LEAVLERHGSQCSNSSASIVP-DSCP--AKDPVTLGQHTPGQG-----------------
-----LTSKRCIEYPVSQSLR--------ACSSDKHQV---SPDH-LTSENKEPGAGRSP
PPEAQMA-DSQWSAHSQPRRPGDRGHPALQQPAEAPNVEEEELGE-SAHHSTALAHFPR-
QELG---P----------------------------------------------------
-------------------ARS-PT--TAQTDD-PARSA-----------PREDAVSRGK
--PRPLSSARGGRRRRLSMVLSGL

PF00533 // ENSGT00440000034289_0_Domain_3 (2005, 2069)

TTKQSVLVQKFAKKHHIGLTHLMTEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2109)

SMKERRMLDERDFEVRGDVVNGRNHQSPKRAR
ES-----R

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DQKIFGGLDVCCCGPFT---NMPTDQLEWMLRLCGASVVRELSALPVGA---
GAQPVVVMQPEAWT-------ED-AGFLALRQLC----QVPVVTRDWVLDSVALYKRQEL
GAYLIPQGPQKPL-----------------------------

-------------------------------MDLSAVHVDEVQNVLNAMQKIL

PF13923 // ENSGT00440000034289_0_Domain_0 (54, 105)

ECPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LRQ-KNGPSQCPLCKNAVTKRGIQAKWYF
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------

-------------------------------MDLSALRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-NSPEHLKD-EVSLIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVPLSNFGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDM
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARNQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 604)

DTLYERKERNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IEDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PDPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRKLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPPSFTNCSNTS
ELKE------FVNPSLSREEK---EKK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEQN-KC
VSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGREVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSKSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFPVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVRS-FVKTKCK-----K------NLLEENSEEHSVSPERT
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPQLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHVSEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLYKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKGSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NPEEQSVDSDLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAV
LEAVLEQHGSQPSNSYPSIVT-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPISQNPE--------GFSADKFKV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDMEEQQLEKSGPHNLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRALESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAEYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLITEETTHIVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----PDRKVKLPPSTSQVAGII---GIATTLGSFF-------------VLLLET---
GFHCVGQAGLELQISGDPPNSAS-QSARIIGVSHHAQPRVSFSKAVW-------------
------------------------------------------

-------------------------------MDLSAVRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCRFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQCNA-----------------------VIMGMRYHSQP
QRFYTEPANNC--LTQETS-LSVPLSNFGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDM
VNKATYC---SVGDQELLQITPQGTRDETSLD-SAK--KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARNQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 604)

DTLYERKERNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLS
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
ESN-IEDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PDPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRKLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPPSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEQN-KC
VSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGREVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSKSLKKQSPKVTSECEQ-KEENQG
KKESNIKPVQTV-NITAGFPVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVRS-FVKTKCK-----K------NLLEENSEEHSVSPERT
VGNENII-----PSTVSTISHNNIRENAFKEASSSNINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPQLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHVSEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLYKNTEENLLSLK--NSLT-DCSNQVI-LAKASQEHHLSEETKGSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NPEEQSVDSDLGEAASGYESETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAV
LEAVLEQHGSQPSNSYPSIVT-DSSA--LEDLRNPEQSTSEKGICFLIPF----------
--KAVLTSQKSSEYPISQNPE--------GFSADKFKV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDMEEQQLEKSGPHNLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRALESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAEYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLVYKFARRYHIALTNLITEETTHIVMKTGI
PRTFT----------------EY-----------FAFAHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
VSICCP---------------VR-EEGHTIGQMC----EAPVVTREWVLDSVALYQCQEL
DAYLIPQIPHSHY-----------------------------

----------------------------------------------------------LE
LIKEPVSTKCDHIFCK------------------------------------SLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFAKK-EN-NSPEHLKD-EFSIIQSMGYRNRA
KRLRQSEPQNP--TLQETS-LSVQLSNPGIVRS-LRTKQWIQPQNTSVYIDLGSDSSEDT
INKKTYC---SVGDQELFQITPQGTRDETSLD-S--AKKAPCEFSEKDITNTEHHQSSNN
N-------------LNTTEKHATERH--PEKYQ----GSSVPNLHVEPCGTNTHASSL--
QHENSSLLLTKDRLNVEKAEFCNKSKQPGLARSQHNRWAESEETCNDRQ-TPSTEKKVD-
-----LDA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLHGRKEWNKQKPPCSENSNNDTED-VAWMTLNSSIQKVNEWFSRSDELLT
SDDSHDEGSESNAKVAEALEV--LNEVDGYSSSSEKIDLLASDPHDASICKSERVHCKSV
-ESSIEDKIFGKTY-RRKASLPNLSHETEN-LIIGALVTEPQ-ITQ---EHPFT-NKLKR
KRRV--TSGLHPEDFIKKADLAV-QKTPEKINQGTNQMEQ----NDQVMNITNSGHENKT
KDDSIQNVNN---PNPVESLEKE-SFRSKAEPISSSISNMEQELNIHNS---KASKK-NR
LRRKSSTRHIH---ELELVVSR-----NLSPPNYTEVQIDSCSSSEEIKKK-NYNQMPVR
HSRKPQLVEDKEHA--TGAKKSSQPN-EQTNK--RHASDTFPEPRLTNIPGSFTNCSNTN
ELKE------FVNRSLPREEK---EEK--PETVKLSNDARDPKDLMLSGES-VLQIE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKELIHGCSK-----DTRNGTEGFK---YPLGPEVNYS-QETSIDMEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEKECAAFSAHSRSLKKQSPKVTLECEQ-KEENQG
EKESNIEPVETV-NITAGIPMVCQ--KDK-PVDYAK-CIEGGSRLCLSS-QFR-GNETEL
ITPNKHGLLQNSYHIPPLIPTRSFI-ETKCK-----------KNLLEENSEEHSVSSERA
MGNKNII-----PSTVSTVSHN-NREKAFKETSSSSINEVGSSTNEVGSSINEVGSSDEN
IQ---AEMGRNRRPKLNAMLRLGLLQPEIYKQSLPISDCK-HPEI-------KKQE-HE-
EVQTVNTDLSPCLISD-NLEQHVG-SSHTSQVCSETPDDLS-DEGEIKED--TSFAEYGS
KETS---------AIFSKSVQR---GELSRSPSPFTHT--HLAQVY-QRGTKKLESSE--
ENLSSEEEELPCFQHLLFG---------------------------KVSNTP-QSTRHST
VATECLSKNTEENLLSLK--SSLN-DCSNQVIL-AKASQEHHLSEETKCSGSLFSSQCSE
LEDLTTNTNTQDPFLIDS--SKRMRHQSGSQGVGLS--DKELVSD-DEERGKDLEE---D
N-QEEQSMDSNLGEAAFGYESETSITEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSHSSPSVIT-DSSA--LEDLRNPEQSTSE--K----------------
A---VLTSQKNSEYRISQNPE--------GLSADKLEV----SPDSSTSKNKEPGVERSS
PSKCQSL-DDRWCMHSCSGSLQNGNYPSQEEL-IKVDMEEQQLEKSGPHDLMEPSYLPR-
HDL---------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DA
EFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPRRAR
ES-----QGK

PF00533 // ENSGT00440000034289_0_Domain_5 (2111, 2211)

KIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GIRAVVVVQPDAWT-------ED-SGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

-------------------------------MDLSADRIEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQENTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSKK-QN-ISPEHIKE-EVSIIQSMGYRNRA
KRLRQSEPENP--SQE-TS-LGIQLSNLGIVRS-LRTKQQTQPQNKSVYIELGSDSSEDT
VNKASYC---SVGDHKLLEITPQGTKAETSLN-P--AEKAACEFSE-DITNTEHHRSSNK
D-------------LTTTEKHETEKH--PEKYQ----GVSVSNLHVEPCGTDTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPVLPRSQQSRWAESKDTCNDRQ-TPSTEKKVV-
-----LNADRLYGSEELNKQKPACSDSPR-GSQD-VPWITLNSSIQKVNEWFSRS-ELLP
SDDSHEGGPESNSEVPGCRGV--PNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXX-XXXXXXXXXXXXXXX-XXXXXXXXXXX-XXX---XXXXX-XXXXX
XXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX----XXXXXXXXXXXXXXXX
XXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXMELELNTHSS---KAP-K-NR
PRRKSSTRQIH---ALELIVSR-----NPSPPNHTELQIESCSSSEEMKEK-HSDQMPVR
HRKKLQLTGDKEPT--TGTKKSNKPH-QQINK--RLVGNTFPELNLTNTPGFFTKCSSSN
KLQE------FANPSLQRE------EN--PGAIQVSNSTKDPKVLILSGGR-GLQIE---
RSVE-NTSISLVPETD--------YDTQDSVSLLEADT---------L-GKAKTAPN-QC
VSLCAATENPKELIHSCSK-----DTRNGTAGFK---DPLGCDVNHT-QEASMEVEESEL
DTQYLQNTFKVSKRQTFALFSNPGDSEKECATIYAHSGPLREQSPKITLECGQ-KEENQR
KSKSEIKHMQAV-HTTLNFPVVGQ--KDK-PSDYAKYSPKGISRLCWPS-QLR-GNESEF
IIANKHGILQNPYLITSLSPNRSSV-KTMCK-----------KNPSEEKLEKCVISPKRV
MGNESTI-----QSIVSAMSQNNIRESTFKEVSSSSVNEVGSSTNEVGSSINEVGSSGEN
IQ---AELGRNMGPKLNAMLRLGLLQPEVCKQSLPVSSCK-QPEI-------KRQGENEG
IFQAVNTDFSPCLISD-NLEQPMG-SSHASQVCSETPDDLL-YDDEIKEN--TSFAESDI
KERS---------AVFSKSVQK----EFRRSPSPLVHT--HLAQGH-QRGARKLESSE--
ENVSSEDEELPCFQHLLFG---------------------------KVTNTPSQSARHNT
IATESLSKETEENLVSLK--TSLN-DCSDQVTS-AKASQERHLSXXXXXXXXXXXXXX--
------------------------------X-----------------------------
---------------------------XXXXXXXXXXXXXXXQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSRSSPSLVA-DSCA--PEDLLNPEQNTSE--K----------------
A---VLTSEKSSEYPISQNPE--------SLSADKFKG----SLDSSTSKNEEPGRERSS
PSRSQSS-DNRWYTHSHSRSLQSRNCQSQKELIKVVDVEEQQLTKSEAQDLMEPSYMPG-
QDLEG-TPYLKSGISLFSD-------NPASNPSEDRAP---NVC----------SMPSST
SALK----LPQF--QVEESAES-PA--AAHTTK-TAGCN-----------VREESVSREK
--PEVISS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-PKTGNKRISMVASGLTPKELMLVQKFARKHHITVTNLVTEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKMLDVHDFEVRGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFKGLEICCYGPFT---NMPTDQLEWMVHLCGASVVKEPSSFTRSE---
GTHSIVVVQPDAWT-------ED-SGFHVIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQLPHSCC-----------------------------

-------------------------------MDLSAVQIEEVQNVLHAMQKLLECPICLE
LIKEPISTKCDHIFW-----------------------PSQCPLCKNEITKRSLQGSTRF
SQLVEELLKITDAFELD--TGMQCKCYTTR----------RQCSR-GPSLLHVVGYPWTG
A------PGFY--KRK-DN-LSVQLSNLGIVRR-KS--RQAQPRNKSVYIELGKGL----
----------FIKYEI--------------II-P--RLFAACEFSE-DVTNIELHQCSNK
D-------------LNPIENHATGRH--PEKCH----GISVSNLHVEPCGTDIHASSL--
QHENSSLLLTEDRMNVEKAEFYNKSKQSGLTRSQQNRWADSKETCNDRQ-IPSPEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 560)

DSLCGRKKWNNQKSLCPENSR-ATQD-VPWMTLNSSIQKVNEWFSKTGEMLT
SDGTSDRRCESNAEANVVLEV--SDEVDGCSSSSKEMDLMANNPDDALKGKSERDLSKPV
-ENNIRDKIFGKTY-QRKGMISEG------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------E-QEENQG
HEEAEISDIQAG-PVAVGLPLLHQ--GGE-PGADTM--RAAVSRPCPSS-QYR-SNENDL
STACHPGIPQNSHPKQSLSPIMSSI-KTGHG-----------KTLSEEQFEKHTLSNEKA
VGNETFV-----QSTIHTISQNH-IKNACQEANSG--------------SINDMSSNGEN
FQ---GQLGRNRGTKLNTVPPLGLMQPGVCKQSFPVSDYK-YLEI-------KKQ--E--
-GEAVGSNFSPCLFSD-KLEQPMG-SGNVFQVCSETPDDLL-DDVEIQEN--TSFAEGDI
MEKS---------AVFNGSVQR---REFSRSPSPLTHT--SLTRSL-QRRSRKLESSE--
ESGSCEDEDLPCFQHLL-G---------------------------Q-------------
----RLSEKAEGTRVPWK--SSIG-DCDNEVIL-VEASQEHRPSEDAEYSGSMFSSQHSA
VQDSTANAASRDLL--FNPPSRQKSPQSEDEEDFLS--DKELISD-DEEMGTCLEE---D
NDQEEDIIIPDSGQS--GFCCEYQAM--CD----CWFSLVLQQRATMKDNLIKLQQEMAH
LEAVLEQQGDQPSGHSPSLIA-DPCA--TEDPPNPEQNISGTA-----------------
----SLTSKSINENPVSRNLT--------CISADKFQP---QPPDSSRSENKESRGGRPS
PFKSPLA-GSRCSAHSRSGSLQNRNCPSQEEPLQVVEAGK----SGKRHNLTGPSCLPR-
QDLEG-TPYLGSGISLFSN----------RDPESESPKGPAYVC----------TAPAST
SAWT----ISQY--PVSESVKE-SP--AAAHAH-T---------------AVVETVSKKK
--PELTSS-KGRANTGISMVVSGLTLKEVMIVQKFAEKYHLTLTDIITEETTHVIMKTGI
LQTFTDYIAFISN---------------HI---KSHINQLFEVKGNTALVAYKL----KS
RS-----G-HKVSMWITMV---VLH---PSSADELERMLQLCGASVVKELSSLTRDT---
VEAH-VIPVSRGWT-------FTSNRPSEIGQLG----EAHLVMWDWVLDSISVYQCRDL
DAYLVQNITHGCD-SSEPQD-----PND--------------

-------------------------------MDLSAVRVEEVQNVINAMQKILECPICLE
LIKEPVSTKCDHIFCSDVLIIEVFYCCCILFLFV-YMSFLILVVFLKQFNFRSLQESTRF
SQLVEELLKIIHAFQLD--TGLQFANSYNFAKK-EN-HSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVPLSNFGIVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRDETSLD-SA---KAACEFSEKDITNTEHHQSSNN
D-------------LNTTEKHATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENS-LLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWTGSKETCNDRQ-TPSTEKKVD-
-----LNAN

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALYERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLN
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEPLICKSERVHSSSV
EIN-IKDKIFGKTY-RRKANLPNLSHVTEN-LIIGALVTESQ-IMQ---ERPLT-NKLKR
KRRT--TSGLHPEDFIKKADLAV-QKTPEIINQGTNQMEQ----NGQVMNITNSAHENKT
KGDSIQNEKN---PNPIESLEEESAFKTKAEPISSSINNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKNYNQMPVR
HSRNLQLMEDKESA--TGAKKSNKPN-EQTSK--RHASDTFPELKLTKVPGSFTNCSNTS
ELKE------FVNPSLSREEK---EEK--LETVKVSNNAKDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTERN-KC
MSQCAAFENPKELIHGCSE----DT-RNDTEGFK---YPLGREVNHS-QETSIEIEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHSRSLKKQSPKVTSECEQ-KKENQG
KKESNIKPVQTV-NITASFSVVCQ--KDK-PVDNAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPVKS-FVKTKCN-----K------NLLEENSEEHSVSPERA
VGNENII-----PSTVSIISHNNIRENAFKEASSSSINEVGSSTNEVGSSINEVGSSDEN
IQAE---LGRNRGPKLNAVLRLGLLQPEVCKQSLPISNCK-HPEIKK----QEH----EE
LVQTVNTDFSPCLISD-NLEQPMG-SSHASEVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRK-GAKKLESSE--
ENFSSEDEELPCFQHLLFG---------------------------KVSNIPSQTTRHST
VATECLSKNTEENLLSLK--SSLT-DCSNQVI-LSKASQEHHLSEETKCSGSLFSSQCSE
LEDLTANTNTQDPFLIG--SSKRMRHQSESQGVGLS--DKELVSD-DEERGTGLEE---D
-NQEEQSVDSNLGEAASGYGSETSVSEDCSRLSSQSEILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIT-DSSA--LEDLRNPEQSTSEK------------------
---AVLTSQKSSEYPINQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCQSL-EDRWYVHSSSGSLQNGNYPSQEELIKVVDVETQQLEKSGSHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESAHVG----------SIPSST
SALK----VPQW--QVAESAQS-PA--AAHNTN-TAGYN-----------AMEESVSREK
--PKLTAS-TERVNKRMSLVVSGLTPEEFMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

YKFARRYHIALTNLISEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKERKMLNEHDFEVRGDVVNGRNHQGPKRAR
ES-----P

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GFHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

----------------------------------------------------------LE
LIKEPVSTRCDHIFCXXXXXXX---------XXXXXXXXXXXXXXXXXXXXXX-X--XXX
XXXXXXXXXXXXXXXXXXXXXXXXANNYNFSKK-EN-NSPEHVKE-EVSIIQSMGYRNRA
KRLRQSESEHP--TLQESS-LSVQLSNLGIVRS-LRTKQQVPAQNKSVYIELGSDSSEDT
VNKASEY---STHE---LHIITQEVRAEPRLN-S--GKNAAYEHSE-NITDNECHQSSKK
D-------------LTTTEKHAAEKH--PETYQ----GTSVSNLHVDPCGTNPHTSSL--
QRENSSLLLTKGKMNVEKAEFCSKSKQPGLARSQQSRWAENMETCNDRQ-TPSPDKEVD-
-----LNADSLYERKELNEQISSYSSSPK-DSKD-ISWVALN-SIQKVNEWLSRSDELLT
SDDSYDKGSKSKTEVTVTTEV--PNAIDRFFGSSEKINLTASDPHVALIREGEGVHFKPV
-KNNIEDKIFGKTY-GRKASLLNLSHVTED-VIIRE----PQ-VAK---EPLLA-TKLKR
KRRT--DVGLCPEDFIKKVDVAIVQKTPEKIIKRPGQLDQ----SDQVMNIATNGHETET
KSDYVQKEKN---ANPAESPEKESAFRNKPEPISSSISNMELELNVHSS---KAPKK-NK
LRRKSSARHIH---ALEVVVNK-----NSSPPSHTELQIDSCSSNEEMRGV-KADQMPVR
HSKQLPLIEDKEPA--TKAFSSSKSN-EQISK--QFVGETFSDLNLTNIPGFLTSCSSSN
KHQE------CINPNLQREVL---GES--RGTIQVCNNTKNPKDLIVSGKR-GLQIE---
RSVE-----SPVENTD--------YGSQDSISLLETDT---------L-GKAKKTPN-QC
VSLCVATETPKELSHSCSK-----DTRNDTEGFR---DSLRCEVDHT-QETSTELEESEL
DTQYLQNTFKVSKRRSFALFSSPENSEKACTRGSVHSKSLRKQSPKVILDCEQ-KEENQG
EKASEIKYLPSE-HTTTGFPVVCY--KDT-SGDYAKCSVKGXXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX---XXX----------------XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXNTISQTNASENALKDVSSSSVNDMGS-------STNEVGSSSEN
IQ---AKLCRNRGPRLNATLRASLMQPEVFEQCLLMSNCK-HSEM-------KRQGENEG
VIQTVNIESDSCPRPD-NLEQPVE-TS---HVCSETPDDLL-NDDEMKEN--TSFTESGI
KEQS---------AVFGKSTQK----GFRRSPSPLGHT--CLRQDQ-QRGAQKSEPSE--
DFMSSEDEELPCFQHLIFG---------------------------NTSSTPSQSTRSNA
VPTEGLSKKTEELLVSLK--GSLT-CDSQQVTS-AKASQEHHLSEEAKFSSSLFSSQCSI
IEDMTTNPSNHDPFLMFDPPSKQGRSQSEDE-EILS--DQELISD-DDEREPGLEE---D
DNQKEQNVDSNLGERGFEYQSETSLSEDSSGLSSQSVILTTQQRDTMQDNLIKLQKEMAE
LEAVLEQHGSQPSNSSTSSTA-DSRA--PADLLNPEQNKSE--K----------------
E---ALTSEKSNKYPASQNSE--------N-SADKLKV----SLDNSTNKSQELGAE---
YSRSQLL-DSKLYVHSPSKNLRKGNCPSQEELTEIADKEEQQRTQSEAQDLMKQSYLPG-
QDLXX-XXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXX-----------XXXXX
XXXX----XXXX--XXXXXXXX-XX--XXXXXX-XXXXX-----------XXXXXXXXXX
--XXXXXX-XXXXXXXXXXXXXXXXXXXX

PF00533 // ENSGT00440000034289_0_Domain_3 (2010, 2070)

MLMHKFARKHHITITDLITEETTHVIMETDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_4 (2070, 2108)

IKENKMLDELEFEVQGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_4 (2108, 2132)

QDRKIFKGLEICCYGPFT---NMP

ENSGT00440000034289_0_Linker_4_6 (2132, 2200)

TXXXXXXXXXXXXXXXXXXXXXXXXX---
XXXXXXX-XXXXXX-------XXXXXXXXTGKMC----E

PF00533 // ENSGT00440000034289_0_Domain_6 (2200, 2212)

IPVVTREWVLDSVALYECQEL
DTYLVTHINRSCR-----------------------------

-------------------------------MDLPADRVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-RKGPSKCPLCKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFSKK-EN-NSPEHLKE-EVSIIQSMGYRNRA
KRLRQNEPENP--TLQETS-LSVQLSDLGILRS-LRTKQQIQPQNKSVYIELGSDSSEDT
VNKASYC---SVRDDELLQITPQGSRTEASLN-P--AKKAACEISE-DITNSERHQSDNK
D-------------LTTTEKHATEKH--PEKYQ---------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------GEVASGYQSETSFSEDCSRLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSRSSPSPVA-GSCA--PEDLLDPEQNTSE--K----------------
A---VLTSEKSSDYPKSQNPE--------SLSADKYQV----SLDSSTGKNKEPGTRRSS
PSQSRLL-DTRWYVHSCPRSLQDTDCPSQKELIKVVSVEEQQASRSEARDFMEQPYLPR-
PDLEG-TPYLESGISLFSD-------DPESDASTDRAPEPAHVS----------RMPAAT
SALK----LPQF--QVEESAKS-TA--AVHIAN-TAGYN-----------KREDSVGREK
--PEVISS-IKRVNRRISMVASGLTPKECMLV

PF00533 // ENSGT00440000034289_0_Domain_3 (2013, 2070)

HKFARKHHITLTNQISEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

IKERKMLDEHDFEVRGDVVNGRNHQGPKRAR
ES-----RD

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2212)

RKIFRGLEVCCYGPFT---NMPTDQLEWMLRLCGASVVKEPSLFPLSK---
GAHPVVVVQPDAWA-------ED-SGFHAIGQMC----EAPVVTREWVLDSVALYQRQEL
DTYLIPQIPRAAAHSSQPCV----------------------

-------------------------------MDLSALRVEEVQNVINAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIICAFQLD--TGLEYANSYNFAKK-EN-NSPEHLKD-EVSIIQSMGYRNRA
KRLLQSEPENP--SLQETS-LSVQLSNLGTVRT-LRTKQRIQPQKKSVYIELGSDSSEDT
VNKATYC---SVGDQELLQITPQGTRNEISLD-SAK--KAACEFSETDVTNTEHHQPSNN
D-------------LNTTEKRATERH--PEKYQ----GSSVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRR-TPSTEKKVD-
-----LNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLCERKEWNKQKLPCSENPR-DTED-VPWITLNSSIQKVNEWFSRSDELLG
SDDSHDGGSESNAKVADVLDV--LNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSV
ESN-TEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-IIQ---ERPLT-NKLKR
KRRA--TSGLHPEDFIKKADLAV-QKTPEMINQGTNQMEQ----NGQVMNITNSGHENKT
KGDSIQNEKN---PNPIESLEKESAFKTKAEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSTRHIH---ALELVVSR-----NLSPPNCTELQIDSCSSSEEIK-KKKYNQMPVR
HSRNLQLMEDKEPA--TGVKKSNKPN-EQTSK--RHDSDTFPELKLTNAPGSFTNCSNTS
ELKE------FVNPSLPREEK---EEK--LETVKVSNNAEDPKDLMLSGER-VLQTE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKGLIHGCSK----DT-RNDTEGFK---YPLGHEVNHS-RETSIEMEESEL
DAQYLQNTFKVSKRQSFALFSNPGNPEEECATFSAHCRSLKKQSPKVTFEREQ-KEQNQG
KNESNIKPVQTV-NITAGFPVVCQ--KDK-PVDYAKCSIKGGSRFCLSS-QFR-GNETGL
ITPNKHGLLQNPYHIPPLFPIKS-FVKTKCK-----K------NLLEENFEEHSMSPERE
MGNEN-I-----PSTVSTISRNNIRENLFKEASSSNINEVG-------SSINEVGSSDEN
IQAE---LGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCK-HPEIKK----QEY----EE
VVQTVNTDFSPCLISD-NLEQPMG-SSHASQVCSETPDDLL-DDGEIKED--TSFAENDI
KESS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQGYRR-GAKKLESSE--
ENLSSEDEELPCFQHLLFG---------------------------KVSNIPSQSTRHST
VATECLSKNTEENLLSLK--NSLN-DCSNQVI-LAKASQEHHLSEETKCSASLFSSQCSE
LEDLTANTNTQDPFLIG--SSKQMRHQSEIQGVGLS--DKELVSD-DEERGTGLEE---N
-NQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSYPSIIS-DSSA--LEDLQNPEQSTSEKDSHIHGQRNNSMFSKRPR
EHISVLTSQKSSEYPISQNPE--------GLSADKFEV----SADSSTSKNKEPGVERSS
PSKCPSL-DDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDKAPESAHVG----------NIPSST
SALK----VPQL--KVAESAQS-PA--AAHTTN-TAGYN-----------AMEESVSREK
--PELTAS-TERVNKRMSMVVSGLTPE

PF00533 // ENSGT00440000034289_0_Domain_3 (2008, 2070)

EFMLVYKFARKHHITLTNLITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2111)

IKERKMLN-----------------------
----------

PF00533 // ENSGT00440000034289_0_Domain_5 (2111, 2211)

EIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GVHPIVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

---------------------------------LPADRVEEVQDVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-RKGPSQCPLCKNNITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFVNSYNFSK--EN-NSPDHLKE-EVSIIQSMGYRNRA
KRLRQSEPENP--TLQETS-LSVHLSDLGIVRS-LRTKQQIQPQNKSVYIELGSDSSEDT
VNKASYC---SVGDDELLQITPQGARAEASLN-P--AKKAACEISE-DITNIEYHQSGNK
D-------------LTTTEKHATEKH--PEKYQ----GISVSNLHVEPCGTNTHASSL--
QHENSSLLLTKDRMNVEKAEVCNKSKQLGLARSQQSRWAESKETCNDRQ-TPSTEKKVL-
-----LNADPLHGRKKPRKQKPACSDCPR-DSQD-VPWITLNSSIQKVNEWFFRSDEMLT
SDDSHDGGSESNTEVAGAVEV--PNEVDGYSGSSEKVDLMASDPQDALIRGSERVHPKSV
-ESNIEDKIFGKTY-RRKASLPS--HTNED-LIIGVRAIEPQ-TTR---AHPLT-NKAKC
KRRT--TSGLLPEDFIKKVDLAVVPKTPEKLVEGTNQIAR----NGHLMNITNNGPENEA
KGDYVQNEKN---ANPTESLEKESAFRSKAEPISSSISNMELELNSCCS---KASKK-NR
LRRKSSTRHAC---ALEFVVNR-----NPSPPDHSELQIDSCSSSEEMKKQ-HLDRMPVR
HSKTLQLMEGKEPA--TGARRGSKPG-EQINK--RLASHAFPELNLTSVPGFSANCSSSN
KPQE------FVNPGLQREEI---EES--LGRIRVSDSTRDPKELLLGGGR-GLQTE---
RSVE-SIHISLVPDTD--------YGTQDSISLLEADT---------L-RKAKTAPN-RR
ANLCAATENPKEPIHGCSK-----DTRNDTEGFA---DPLTCEDNHT-QETRIAMEESEL
DTQYLYNTFKVSKRQSFALFSNPGDPEKDCAMVCAHSGALRKQSPKVTLEGGQ-KEENQG
KKESEIKHVQAV-HATAGFSAVSQ--QAKKPGDYAKCSIKGGAKLCPSS-PFR-GKETEL
LIANNRGISHNPYHIPPLSPIRSYV-KTLCK-----------KNPSEERFEQHSMSPERA
MGNESVI-----QSTVSTISQNNIRESTLKEVSSSSVNEVGSSTNEAGSSINEVGSSGEN
VQ---AELGRHRGPKVNAMLRLGLMQPEVYKQSPPVSNCK-HPEM-------KRQGENEG
VVLSVNADFSPCLISD-NPEQPMG-STHASQVCSETPDDLL-NGDKIKGK--SSFAESDI
RERS---------AVFSKSVQK---GAFGRSH--LDET--HLAQGH-QRGARKLESSE--
ENTSSEEEELPCFQHLLFG---------------------------KVTNTPSQPTSHNA
VATEGLSKKTEENLDSRK--NSLS-DLSNQGPS-AKASQEHYLSEEARCSGSLFSSQHSA
LEDLIVTTNSQDPFLMFDSPSKQVRHQSENL-DVLS--DKELVSDDDDERELGLDE---D
N-HEEQSVDSDLGEAASGYESETSLSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSRSSPSLLA-GSGA--PEDLLNPEQNTSG--K----------------
A---VLTSEKSSDYPISQNPE--------SLSADKFQV----SLDSSTSKNKEPGTRRSS
PSPSRLL-DTRWYVHSGPRNLQNRNCPSQKELIKVVSVEEQAPTKSEAQEVVEQ-SLPR-
PDLEG-TPYLESGISLFSD-------DPESDPSADRAPEPAHVS----------SMPTST
SALK----LPQF--QVEESAKS-TA--AVHVAN-TAGYN-----------KREDTVGREK
--PEVISS

PF00533 // ENSGT00440000034289_0_Domain_3 (1989, 2070)

-VKKINGAISMVASGLTPKEFMLVQKFAKKHHIALTNQISEETTHVIMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IKERKILDEHDFEVRGDVVNGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QDRKIFRGLEVCCYGPFT---NMPTDQLEWMVHLCGASVVKEPSSFTLSK---
GTHAVVVVQPDAWA-------DN-SGFHAIGQMC----EAFVVTREWVLDSVALYQCQEL
DTYLIPQIPRAAAPASQPCA----------------------

-------------------------------MDLSAVHVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNDITKRSLQESTRF
SQLVEELLKIIHAFELD--TGLQFANSYNFAKK-EN-NSPEHLKD-EFSIIQSMGYRNRA
KRLRQSEPQNP--TLE-TN-LSVQLSNPGIVRS-LRTKQWIQPQNKSVYIDLGSDSSEDT
INKKTYC---SVGDQELLQITPQGTRDETSLD-S--AKKAPCEFSEKDITNTEHHQSSSN
N-------------LNTTEKHATERH--PEKYQ----SSSVSNLHVEPCGTNTHASSL--
WHENSSLLLTKDRLNVEKAEFCNKSKQPGLARSQHNRWAESEETCNDRQ-TPSTEKKVD-
-----LDA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 603)

DPLHGRKEWNEQKPPCSEKPRDDTED-VAWLTLNSSIQKVNEWFSRSDELLT
SDDSHDEGSESNAKVAEALEV--LNEVDGYSSSSEKIDLLASDPHDALICKSERVHCKSV
-ESSIEDKIFGKTY-RRKASLPNLSHVTEN-LIIGAFVTEPQ-ITQ---EHPLT-NKLKR
KRRV--TSGLHPEDFIKKADLAV-QKTPEKINQGTNQMER----NDQVMNITNSGHENKT
KGDSIQNENN---PNPVESLEKE-SFRSKAEPISSSISNMELELNIHNS---KASKK-NR
LRRKSSTRHIH---ELELVVSR-----NLSPPNYTEVQIDSCSSSEELKKK-NYNQMPVR
HSRKLQLMEDKERS--TGAKKSSKSN-EQ-SK--RHASDTFPELRLTNIPDSFTNCSNTN
ELKE------FVNPSLPREEK----EK--LETVKLSNDAKDPNDLMLSGES-VLQIE---
RSVE-SSSISLVPGTD--------YGTQESISLLEVST---------L-GKAKTEPN-KC
VSQCAAFENPKELIHGGSK-----DTRNGTEGFK---YPLGPEVNYS-QETSIDMEESEL
DTQYLQNTFKVSKRQSFALFSNPGNPEKECATFSAHSGPLKKQSPKVTLECEQ-KEENQG
EKESNSEPVETV-NITAGFPMVCQ--KDK-PVDYAK-GIEGGSGLCLSS-QFR-GNETGL
IIPNKHGLLQNPYHIPPLIPTRSFI-KTKYK-----------KNLLEENSEEHSMSPERA
MGNKNII-----PSTVSTISHN-NRENAFKETSSSSINEVGSSTNEVGSSINEVGSSDEN
IQ---AEIGRNRRPKLNAMLRLELLQPEMYKQSLPISNCK-HPDT-------KKQE-H-E
VVQTVNTDLSPCLISD-NVEQHMG-SSHTCQVCSETPEDLL-DDGEIKED--TSFAEYGI
KETS---------AVFSKSVQR---GELSRSPSPFTHT--HLAQVY-QRGAKKLESSE--
ENLSSEEEELPCFQHLLFG---------------------------KVSNTP-QSTRHNT
VAIECLSKNTQENLLSLK--SSLN-DCSNQVIL-AKASQEHHLSEETKCSGSLFSSQCSE
LEDLTTNTNTQDPFLIDS--SKQKRHQSESQGVGLS--DKELDSD-DEERGIDLEE---D
N-QEEQSMDSNLGEAAFGYESETSITEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSHSSPSVIT-VSSA--PEDLQNPEQSTSE--K----------------
----VLTSQKSSEYPISQNPE--------GLSADKFEE----SSDSSTNKNKEPGVERSS
PSKCQSL-DDRWCVHSCSGSLQNGNSPSQEEL-IKVDVEEQQLDKSGPHDLMEPSYLPR-
QDLEG-TPYLESGISLFSD-------DPESDPSEDRAPESSHAG----------SIPSST
STLK----VPQF--QVAESAKS-LA--AAHTTN-TAGCN-----------AMEENVSRQK
--PELAAS-TERVNKR

PF00533 // ENSGT00440000034289_0_Domain_3 (1997, 2070)

KSMVVSGLTPEELVPMYKFARQHHITLTNQITEETTHVVMKTDA
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2110)

IKERKMLNEHDFEVRGDVVNGRNHQGPRRAR
ES-----QG

PF00533 // ENSGT00440000034289_0_Domain_5 (2110, 2211)

RKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSSFTLGT---
GIHAVVVVQPDAWT-------ED-NGLHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHY-----------------------------

--------------------------MEQKEMDLSTVHVEEVQNVLNAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIREPVSTKCDHIFCKFCMLKL---------LDQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 430)

CKNSITKRSLQESTRF
SQLVEELLKVIRAFELD--SGLQVANSYNFSKK-EI-NSPEHGQE-EIPLIQSMGYRNRA
RGLRQGEPEKP--SL-ETS-LGVQLSDLGIVRS-LRTKKQAQPQNKSVYIELGSDSSEDA
SEDVANRADDHSVRDQDLLFSLQGTRAKASSH-P--AKQAPCEASEKGTVDSDRPHLSGE
D-------------EKPVEKRAAKRR--PGKQQ----VGPAPDLRVEPCGTDTRASSL--
QCRNSRLLLTEDRMDVEKAEFCNKSKQPGFARSQQSRWAGSEESSDDGQ-TPSTEQKAE-
-----PTAA

PF12820 // ENSGT00440000034289_0_Domain_1 (430, 604)

ALCERRG-KEQKPPCSETLG-EAQD-VYWVTLNSRIQKVNEWFSRSDKVVA
SDDACDRELEADAEEASALED--PKGQGGFSGSLEKIAMLTNSPQSALFCANKRVCPKAG
-RNDMKDKVFGKTY-RRKPSLPSFTYVAEN-LTVGALVVKPQ-VTQ---EFPPT-NKLKR
KRRS--MSCLHPEDFIKRADLPVAPKTPEKINQGTEQMEE----SGQVTGTPRKSHKGDA
EGAGVQRQRK---PSPAQSLEKESAARAE--PQSCSISNMGLESHARHS---EPPKK-SR
LRRRSSTRHVP----------------HPSPLDHTELQIDNSTSTEEVKEK-SSHQVLIG
YSQNLYLAGEGEAS--IGIPESKKPA-EQVRN--RPAEEAVPEPALANTPGSSA--NSSG
PDKE------LVNPSPQRDKT---EEN--PETVQVSDNTRDPKGPVLSGER-GLQTE---
RSAE-STSISLVPDTD--------YSTQDSFSLLEANS---------L-RKAQRASH-QC
VTQYVAVAKPKE-LPAHSE-----DTGNDTEGFN---DPLRRKVSHV-QEANVEMEDSEL
DTQYLQNTFQASKRQSFALFSNPGNPEKKSTGVCAHSEFFQKRNPEVTPECEQ-RENSKG
KKASKIRHVQVV-NATASVPVISQ--ND-QLGVGVQCGVTGVSKLRPSS-QVR-GYKTEL
VAADKHGISRNPCHVASVSRIGTSV-KTACK-----------KSLSMS--------PKEA
VESERVL-----QSMVSTGCCKNSRDLAPKEASSGSGSGV-------GSGTNEVASSNEH
MQ---AEWGRSRGPTLNAVLRSGLMQPKVQEQSLPVGDYK-CPKI-------PQRGASGV
VAQAVHADFSPCLIFD-SVEQPMG-SNPASQICSETPDDLL-DEEDRKED--ASFAEDDI
KETS---------AVFSKSVQR---RQFSRSPSPFTH--TALARGH-QRRVRKLESSE--
ENMSSEDEELPCFQHLIFG---------------------------KGCTTP-QSTRPST
GATERVSKGTEENVVSLK--DNLR-GCTSEP-----VSPEPRLGEDIRCSGSLFSSQCSI
SEESAANTISQDPLLMLHPPAEQNGHPSGIQGASLS--DKEVVSD-DEDREPSLEE---G
SHHGGQSVDSPLGEAASGYESETNPSGGFSGLSSQSSILTTQQKDTIQDNLLRLQQEMAQ
LEAVLERHGSQCSNSSTSIVP-DSCP--AEDLATLGRYIPGKG-----------------
-----FTSGRSNAYPVTQSLQ--------ACPSSKHQV---SPDC-PASENKEPGAGRSS
PPEAQVA-DSQWSAHSQPRRLRDRGCPAPEQLE-----EEEELGESGPHHATALAHLPR-
RELVA-EP----------------------------------------------------
-------------------AGT-PA--AAQTSN-PARGA-----------SKEEAVSREE
--PESLSSVGG-GRRRLSMVVSGL

PF00533 // ENSGT00440000034289_0_Domain_3 (2005, 2069)

TTKESVLVQKFARKHHIGLTSLITAETTHVVMKTDP
EFVCERTLKYFLGIAGGKWVVSYFWVTQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2109)

SMQERRMLDECDFEVRGDVINGRSHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFGGLTVCCCGPFT---NMATDQLEWMLRLCGASVVGELSALPLST---
GAQSVVVMQPEAWT-------ED-ADFLALGQLC----QVPVVTRDWVLDSVALHQRQEL
DAYLIPQDPHRPR-----------------------------

-------------------------------MDLSAARIQEVQNVLHAMQKILE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLE
LIKEPVSTKCDHIFCKFCMLKL---------LNQ-KKGPSQCPL

ENSGT00440000034289_0_Linker_0_1 (105, 429)

CKNEITKRSLQGSTRF
NQLAEELLRIMAAFELD--TGMQLTNGFSFSKK-RN-NSCERLNE-EASIIQSVGYRNRV
RRLPQVEPGNA--TLK-DS-LGVQLSNLGIVRS-VKKNRQTQPQKKSVYIELDSDSSEET
VTKPGDC---SVRDQELLQTAPQEAGDEGKLH-S--AEEAACEFSE-GIRNIEHHQCSD-
D-------------LNPTENHATERH--PEKCQ----SISISNVCVEPCGTDAHASSL--
QPETSSLLLIEDRMNAEKAEFCNKSKQPGIAVSQQSRWAASKETCNDRQ-VPSTGEKVG-
-----PNA

PF12820 // ENSGT00440000034289_0_Domain_1 (429, 608)

DSLSDRKKWTHPQSLCPENSG-ATTD-VPWITLNSSVQKVNEWFSRTGEMLT
SDSASARRHESNAEAAVVLEV--SNEVDGGFSSSRKTDLVTPDPHHTLMCKSGRDFSKPV
-ENNINDKIFGKSY-QRKGSRPHLNHVTE---IIGTFITEPQ-ITQ---EQPFT-NKLKR
KRS----TSLQPEDFIKKADSAGVQRTPDNINQGTDPMEP----NEQAVSTTSNCQENKI
AGSNLQKEKN---AHPTESLRKEPASTAGAKSISNSVSDLEVELNVHSS---KAPKK-NR
LRRKSSIRCVL---PLE-PISR-----NPSPPTCAELQIDSCGSSEETKKN-HSNQQPAG
HLREPQLIEDTEPA--ADAEK-NEPN-EHIRK--RRASDAFPEEKLMNKAGLLTSCSSPR
KSQG------PVNPSPQRTGT----EQ--LETRQMSDSAKELGDRVLGEDPSGKTTD---
RSEE-STSVSLVPDTD--------YDTQNSVSVLDPNT---------V-RYARTGSA-QC
MTQFVASENPKEFVHGSN------NAGSGTECLK---PPLRHALNLS--QEKVEMEDSEL
DTQYLQNTFQVSKRQSFALFSKPRSPQKDCA----HSVPSKEPSPKVTAKGKQ-KE-RQG
QEEFEISHVQAV-VATVGLPVPCQ--EGKLAA-DTMC--DRGSRLCPSS-HYR-SGENGL
SATGKSGISQNSHFKQSVSPIRSSI-KTDNR-----------KPLTEGRFERHTSSTEMA
VGNENIL-----QSTVHTISLNNRG-NACQEASS--------------GSIHEVCSTGDS
FP---GQLGRNRGPKVNTVLPLDSMQPGVCQQSVPVSDKY-LEIK-------KQEG----
--EAVCADFSPCLFSD-HLEQSM--SGKVFQVCSETPDDLL-DDVEIQGH--TSFGEGDI
MERS---------AVFNGSILR---RESSRSPSPVTHS--SKSQSL-HRASRKLESSE--
ESDSTEDEDLPCFQHLLSR----------------------------ISNTP-ELTRCSS
AVTQRMPEKAEGTQAPWK--GSSS-DCNNEVIM-IEASQEHQFSEDLRCSGSMFSSQHSA
AQGSTANANSQDS--NFIPPSKQRSHQCGNEEAFLS--DKELISD-NEEMATCLEE---D
NDQEEDSIIL--DSEASGYESETNLSEDCS----QSDILTTQQRATMKYNLIKLQQEMAH
LEAVLEQRGNQPSGHSPSLLA-DPCA--LEDLPDLEPNMSG--A----------------
A---ILTSKNVNENPVSQTLK--------SACDDKFQL---QHLKGPTSGDDESGMGRPS
PFKSPLA-GSRGSAHGRSRCLQKRNSPSQEELLQPAGSEA----SSEPHNSTGRSCLPR-
RELEG-TPYLESGISLFSS-------R---DPKSESPKEPAHIC----------TTPALT
SALK----ISQG--QVAESFRS-AA--AAGADK-----------------AVVGIVSKIK
--PGLTSS-EERADRD

PF00533 // ENSGT00440000034289_0_Domain_3 (1997, 2070)

ISMVVSGLTPKEVMTVQKFAEKYRLTLTDTITEETTHVIIKTDA
EFVCERTLKYFLGIAGGKWIVSYSWVLRS

ENSGT00440000034289_0_Linker_3_5 (2070, 2108)

IQERRLLNVHEFEVKGDVVTGRNHQGPRRSR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

RE-KLFKGLQVYCCEPFT---NMPKDELERMLQLCGASVVKELPLLTHDT---
GAHLVVIVQPSAWT-------ED-SNCPDIGQLC----KAHLVMWDWVLDSLSSYRCRDL
DAYLVQNITCD---SSEPQD-----SND--------------

----------------------------------------------------------LE
LIKEPVSTKCDHIFCXXXXXXXXXXXXXX----------XXXXXXXXXXXXXSLQESTRF
SQLVEELLKIIHAFELD--TGLQFTTSYSFSKK-EN-NSPEQLKE-EVSIVQSMGFRNRA
KRLRQGELEDP--TLQEAS-LSVQLSNLGIVRS-LRTKQQMQPQNKSVYIELGSDSSEDT
VNKTSYC---XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
X-------------XXXXXXXXXXXX--XXXXX----XXXXXXXXXXXXXXXXXXXXX--
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXX-
-----XXXXXXXXXXXXXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXX-XXXXXXXXXXXXXXX-XXXXXXXXXXX-XXX---XXXFT-NKLKR
KRRT--ISGLHPEDFIKKTDLAVVQKTPEKINQRTDQIER----NGQVMSIADSGNENET
KSDYIPKEKN---ANPMESLEKESALRTKAEPISSSVSNVELEINNHSS---EAPKK-NR
LRRKFSARHIR---TLELIGNK-----SPSPPNRTELQIDSYSSSEER--TKKGEQMPVG
HSRKFQLGEEKEPT--TGAKKNNQPN-TEIRE--RRASGVIPDLKLTNIPGFFTNSLSSN
KLPE------FVHRSLQREKV---EEN--QETIQASSST---KDLVLRGER-GLQDV---
RSAE-STNISLVPDTD--------DGTQDSISLLDTNP---------LARKAKTAPN-QC
VNQSETTENPKELIHSCSK----TT-RN--EGFK---DPLKREVNLI-QEMSVEMEESEL
DTQYLQNTFKSSKRQSFALSSNPGNPEKEHSVLK------------------------KS
LKESNIKHIQAV-ST-----TVFQ--KDK-LGDFAKSGIKEVPRLCPSS-QFR-GNETDL
IT-NKPEVSQNPYHMPLLYPVKS-LXXXXXX-----X------XXXXXXXXXXXXXXXXX
XXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXX
XXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX----XXX---XXX
XXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXXX--XXXXXXXX
XXXX---------XXXXXXXXX---XXXXXXXXXXXXX--XXXXXXXX-XXXXXXXX---
XXXXXXXXXXXXXXXXXXX---------------------------XXXXXX-XXXXXXX
XXXXXXXXXXXXXXXXXX--XXXX-XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX--XXXXXXX-XXXXXXXXXX---X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQRDTMQDNLIKLKQEMAE
LEAVLEQQGSQASNSSLSLVA-DSCDSDPEDLLNPEQNTSPK------------------
---AELTSEKSNEYPVSLNPK--------NLSANKLQG----SPESSTSKNKEPEVK---
---------------------RSRNCLSQEGLVKVVDVEEQQLEKSGPHDLKEKTYLPR-
QDLEG-SPYLESGISLFSD-------DPEFDPPEKRAPEPAHVY----------NMPASI
STLK----SSQL--QGADSAKS-PA--AARTTN-TAGDA-----------VREESKSREN
--PELTSS-AERVGERIYMVVSGLTPKESXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXA
EFVCERTLKYFLGIAGGKWVVSYFXXXXXXXXXXXXXXHAFEVRGDIINGRNHQGPKRAR
ES-----

PF00533 // ENSGT00440000034289_0_Domain_5 (2108, 2212)

QNRKIFKGLEICCYGPFT---NMPTDQLEWMVQLCGASVVKELSCFSVGT--X
XXXXXXXXXXX--------XXXX-XXXXXIGQLC----EAPVVTREWVLDSVALYQCQEL
DTYLVPQIPQSRC-----------------------------

-------------------------------MDFSVITIGQVQNVLSAMQKNLE

PF00097 // ENSGT00440000034289_0_Domain_0 (55, 105)

CPICLD
VVQEPVSTKCDHIFCRFCMFKL---------ISKKKKGVVECPLCKTEVTKRSLKENSKF
KQLIEGLLETIHAFELD--TGVKFLKSHHFPQTSTEATATESLCK-ESSVIQSKGFRNRR
KSAKGNEQENI--TLQEAS-VNIQLTDAK--MCHPRNKPQKSDSQKGTYIEFGSESSEEF
FKQATKT---GFEDKGAVQVSPQVRLEELESAEK--GNENTYNAQPDKLCAQEIKLPNVT
GESDFSKECLSKKSTQSIAECAKPDQVNVTECQSSPLNVLAVDLLPQQCDRIGDASPT--
VDGDTSFFKNTEKMDDQQTQYDRENREFDLEDISEGRLDKSKGIDTDVQ-NVEAVEACE-
-----PENDSFHDQEL-PLEQVPQPETLHSATLNKVSKKRLKQSIQKVNEWFSKSNEILS
SSSSLDESAASADVSGEG----DLCLSDKESCISEKTDPMADSMEIV-AVEEKKRQSKQT
-AESIKDKIFGRTY-KRGRKSNPPSTLRA---ILPTRRKEDVA-ADKCLKNFSK-DRLKR
KRKS--ACVLQPEDFIKKKDTEEADGGPQSDDRGLGDAGK-KRCDGSVAV-NESHLSQNR
ANNTLTKL----------EEGGESTLKKATEKVTAKSCDGDPEMHNCDQKSTKKRGS-AA
KRCRHSSRTMC---SLQLVVDR-----DSVFPDAAEPQIDSYPSSGEPRKA-DSEQNPAR
RSRRLQLLSAEMKK--ETKKE--VEGARENNS--DHGRSVSGDQR--SGAAHSAECKDLC
EPQN------ESSYRPVTNLE---RGDLEANEMQVG--LKNLPGTSETGRS-LFNPS---
--RLPSNCGSTVPDT----------SSQDS-EILGSPLLLQLPSVSAG-QTASQKTEE-V
SESPAACPQECG-----------HDPQNVPGDFKSEKLPMAKNV----LELTKEAEDSDL
DTQYLRNIFRHSKRSSFSLFQTP---RKAHAVGDPPSE-------TLTLSCAA-QVENKA
TKQLQPESLQEEKTAAQNLSRVSE--KEKLKACESAHI-------DPVP-CFAVST----
-GEHRDDISQAAEEGTLTPA-RTGTAQTEHKNGLLQEEQDNEKP---------------E
IGTESELRQNPIRSGGSQSDQSNTEHDDSRQNGLN--------------SGQEISFGSES
NQAGKTEVVDCEGPILH-FQSTSMICPATCEQSPAEVSCEVTGTKSSKRERKSVKGNEEQ
AAQTVSTAMPKCSAAE-DLEEPLR-ENHDLGGLSETPDGLLCSDTDID-D--TSLCETDR
KEQS---------AVFVKSDN-ALGKEPHNRNASSEPR-SQGIQKS-RRRVQKLPSSD--
-EESCEDEDLPCFQALIFS---------------------------KSVSTPLQTDKQMA
SLVECP---VSPSMFPHS--VSNGDNIVQKVPEAALSNVCVSPSQGSECSVNLFSSQSNM
SEESPNGAQELKNDLPQAHESKQMSSVNDSKETSQN--CSGRLKTS------------KD
ECQEDPDMGANLGEAGSGSDSEISIVEDSCGPFSQGEILTTQQKNAMQNSLKKLQQEMAA
LEAVLKQNGSQNCEVLPVHRELPPSS--TEGAFEMEQTRKEKTR----------------
SPELLLPSSKSSLT------K--------RLDVEKGPG-----CD-SVLKNKT-----P-
----------SEKTKPVQEAVQEHR-------------------ECQL------------
-------------------EG-ENAKEQKSGTRQNTASVSSDLFGNV-----TQSPDNSS
SSVG----LFIP--QTAEATGG-PV--VAQNTD-KSCGPGHKLKRSECFPVPVLHNATGK
--ESAASP-VVSKRKEMSIVASGL

PF00533 // ENSGT00440000034289_0_Domain_3 (2005, 2069)

NHSEHLVVQKFVKKTQSTLSNHITEGTTHVIMKTDK
ELACERTLKYFLGIAGGKWVVSYQWIIQ

ENSGT00440000034289_0_Linker_3_5 (2069, 2109)

SFKEGRILDEEPFEVRGDVINGRNHQGPKRAR
QA-----L

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2212)

TEKIFKDFEICCCGPFT---DMTTEHLEWMVELCGASVVKQPDLFSHTA---
NSTAVVVVQPDAWK-------EN-VDYGAIPQQS----DVAVVTREWVLDSVACYECQEI
SAYLLS------------------------------------

------------------------------------------------------------
----------------FCMLKL---------LNQ-KKGPSQCPLCKNDITKRSLQESTRF
SQLVEELLNIIHAFELD--TGLQ-------------------------------------
----QSEPENP--TLQETS-LSVQLSNLGIVRP-LRTKQQIKSQNKSVYIELGSDSSEDT
VNKASYC---SVGDEELLKITPQGAKAKTSLD-SAK--KAACAFSEKDITSIEHHQASNN
D-------------LNTIKKHATEMH--PEKYQ----GSSVSNLHVEPCGKNTHANSL--
QHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQQSRWAQSKETCNDRQ-APSTEKKVD-
-----LSTAPP

PF12820 // ENSGT00440000034289_0_Domain_1 (432, 604)

YGRKERNKQKPPYSESPR-DTQD-VPWITLNSSIQKVNEWFSRSDEILT
SDDSHDGGCESHAEVAGALDV--PNEVDGYSTSSEKIDLLASDPPDPIIRKRERLHSKPV
EGK-IEDKIFGKTY-RRKASLPNLSHVTEN-LIIGTIVTEPQ-ITQ---EHPLT-NKLKR
KRRT--TSGLCPEDFIKKADLAVVQKTPEKRNQETNQMEP----NDQVMNVTNSGYENET
KGNYVQKEKN---PNPTESLEKESSFRTKVEPISSSISNMELELNIHNS---KAPKK-NR
LRRKSSSRHIH---ALELVVNK-----NPSPPNCTELQIDSCSSIEEIK-EKNSEQMPVR
HSRKLPLVEDKEPT--TGAKKSNKPN-EQISK--RHAND--------------TNCSSSN
KLQE------FINPGLQREKT---EEN--LETILASNSIKDTKDLVSSGER-VFQTESGE
RSIE-STSISLVPDTD--------YGTQNSISLLEVNT---------L-GKTKTAPK-QC
VSQCAAIENPKELIHGCSK----DT-RNNTEGFK---DPLRHKINHI-QEPSMEMEDSEL
DTQYLQNTFKVSKRQSFALFPNPGNPEKECATVCAHSRSLRKQSPKVTLECEQ-KEN-QE
KKESKIKHEQTI-STTAGFSVVCQ--KDK-PDDYAKCSIREVSRFCLSS-RFR-GNENEL
ISVNKHDILQNPYHIPSLSPIRP-FFKTKCK-----T------NLSEERFEEHSVSPERT
LGSENVI-----PNTVSTISQNNIRESAFKEASSSSINEVGPSTNEAGSSVNEVGSSGEN
IQVE---LGKNRGPRLNAVLRLGLMQPEVYKQSLPVSNCK-HPEIKR----QEK---NEG
VLQTVNTDFSPCLISD-NLEQPMG-SSHASQVCSETPDDLL-DDDEIKEN--ISFAESGV
KERS---------VIFSKNVQR---GEFSRSPSPLAHT--CLVQGHRRREARKLESSE--
ESMSSEDEELPCFQH-LFG---------------------------KVTNMPSQSIRQKT
VATECLSKKTEENLASLR--NSLN-DCSNQVM-LAKASQEHHLSEEAKCSSSLFSSQCSP
LEDLTANRNTQDPFLMFDPPSKQMRNQYENQEIVLS--DKELVSD-DEERETSLEE---D
NDQEEQSVDSNLGEAASGYQSETSFSEDCSGLSSQSDILTTQQRDTMQDNLIKLQQEMAE
LEAVLEQHGSQPSNSSPSLIA-DSCA--PDDLLNLEQNPSEK------------------
---AVLTPQKSSDYPVSQNPE--------SLSADKFQV----SPYSSTSKTKEPRAERSS
SSKSQLS-DDRWYMDSHSGSLQNRICLSQEELVKVVDVEEQQLEKSEPYDLMEQSSLPR-
QDLEG-TPCLESGVCLFSD-------DPESNPSEDKAPDSAPVC----------SMPAST
SALK----LPQF--QVADSDMS-LA--ATHNTE-TV---------------KEESMNKEK
--PELTSS-TERVNKRISM

PF00533 // ENSGT00440000034289_0_Domain_3 (2000, 2070)

VVSGLTPKESMLVHKFARKHHITLTNLVTEETTHVVMKTDT
EFVCERTLKYFLGIAGGKWVVSYFWVTQS

ENSGT00440000034289_0_Linker_3_5 (2070, 2109)

IKEKKMLEEHDFEVRGDVVNGRNHQGPKRAR
ES-----Q

PF00533 // ENSGT00440000034289_0_Domain_5 (2109, 2211)

DRKIFRGLEICCYGPFT---NMPTDQLEWMVQLCGATVVKELSSFTLGT---
DVHPVVVVQPDAWT-------ED-NGFHAIGQMC----EAPVVTREWVLDSVALYQCQEL
DTYLIPQIPHSHC-----------------------------