Query Results 

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHGA-MKPSQGSGSFGAILGSRTSQKEIS-RQLSYSDNQAPAKRGSLETKDDI
PFRKVLGSPGRGSIKAVAGSGIAV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMLSTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEYSPGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFR-EEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKHSVA---LSQRLCEMSGSEQQQ--EDLEKDSKLRRIEPDK-SELE
NSGFDRMSEEEVLAAVLEISKREASPSLSHEDDDKSTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPAGFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKKAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQTLSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRT-FQLNHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKEAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKPSQGSGSFGAILGSRASQKETN-RQLSYSDNQASSKRGGLETKDDI
PFRKVLGNPSRGSIKTVAGSGMAV---------------------SRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGP-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGSNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKNLRCNQD----------YTGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1104)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISTT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENSP-------DASA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
FTSCLDSDSEDE-LKRSVA---LGQRLCDMSGHEQQQ--EDVEKDSKLCRLEPGK-SELE
TSGFDKMSEEEVLAAVLEISRREASPVLSHEDDDKPTSS---PDTGFAE-DD-----VQE
MPENPDAMETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSEVKYVIDKVLVYLHAEIPRFYSYHCINW-------K
VIT--------------------YL-----------------------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDNRVSLLV
HYNTGGIPRV-FQLSHNIKNVVLRPSGIKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKASQGSGSFGTILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDEI
PFRKVLGSPGRGPIKTVTGGGMAV---------------------TRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSCRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDR------CNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YAGWNRPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPFNAL-I-R
RFANLLIKKDICNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENLP-------DTSA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKLGQQVIIPRFLTLASHCTE
STKPPVTLGWSAPVAI-SRPLRACQMVNSCITSPSAPSK----K-------FTFKSKS-S
VTSCLDSDSEDE-LKRSVV---LSQRLCDLPGNEQYQ--EDVEKDLKLCRLEPGK-AELE
NSGFDRMSEEEVLAAVLEISRREASPVLSPEDDDKPTSS---PDTGFAE-DD-----IPE
MPENPDAMEIEKSK-TIT--EPGPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DV----DREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGALPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS-----
------------------------------------------------------------
--------------------

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------------------------

PF00443 // ENSGT00440000033542_0_Domain_5 (1105, 1164)

GH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTSQQEEYLKDFN----YN
---FKLLELTYVCFEL--------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGSKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-IKASQGSGSFGTILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDEI
PFRKILGSPGRGPIKTVTGSGMAV---------------------TRTIPS----MTLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMSEPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGTNLDR------CNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YAGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENLP-------DTSA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLRACQMVNSCITSPSAPSK----K-------FTFKSKS-S
VTSCLDSDSEDE-LKRSVA---LSQRLGDLPGNEQYQ--EDVGKDSKLCRLEPGK-SELE
NSGFDRMSEEEVLAAVLEISRRESSPVLSPEDDDKPTSS---PDTGFAE-DD-----IPE
MPENPDAMEIEKPK-AIT--EPGPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DI----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNS--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTDA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIHEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMKLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKP-QGSGSFGAVLGSRVSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTVSGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--TMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSSVTNLDR------NNVSSQTP
SAKRSLGFLPQPIP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQHQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEAIPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTTI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCTDSDSEDE-LKRSVA---VSQRLCEMSGNEQQQ--EDLEKDSKLSRAESE------
KSEFDRISEEELLAAVLEISKRETSPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MSENPGTVEAEKPR-TVT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DI----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQTWFTYNDLEV-------S
KIQETAVQ-TDRDRSG---YIFFYMHKEIFDELLETEKNSQAFSMEVGKTARPAS-----
------------------------------------------------------------
--------------------

-------MISLKVRGFIQIWSQ----RTGMTKLK---------EALIETVQRKKEIKLVV
TFKSGKFIRI-FQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFL
DIIHQNKFQQP-MKPDDDWSVFESR----NVLKEID-KT---------------------
SFYSICNK--------------PS---------------------YQKMPLF--MSKSP-
THVKKGLLENQGGKEKNPLASGL-Q-MNEDI-LKEH-NPVPNK--KYKTDSLKYIQSNRK
NPSSL---EDLEKASDLKLGPSFKTNS-----------NGHPNLDE-----TVL-ATQTL
DAKNGLTFPLEPV---------------------HSQD----------DPRCNEAQVPLD
SHSEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAILQSL-FAIPSF-ADDLLTQDVPWEYIPFEAL-IMT
L-TQLLALKDFCSTEIKRELLGNVKKVISAV-AEIFSGNMQN-DAHEFLGQCLDQLKE-D
MENLNAILNTGKKCRDENSSPQM--HVGSAA-TKVFVCPVVA-NFEFELQL-SIICKACG
HAV-LKVEPNNYLS-INLHQET-KPLPL-SIQ-NSLDLFFREEEL------------EYN
CEMCK-HKSCVARHTFSRLSRVLIVHLKRYSFN-NAWLLVKNNEQVYIPKYLSLSSYCNE
STKPPLPLSSNAPVRK-CEVLEVSQEMISEITSPLTPSM----K-------LTSESSG-S
LVLPVEPEKNADLQ--------RSQRDCGEE--SQEQHQGDLENGS---ALES----ELV
HFRDRAISEQELPVADSPMDQEDISLPVICEDGGKPISS---PDTRLVE-VH-----LQE
MPQHQELQKYEKTN-TFV--EFDFDSVMESTNGFYECKENRIPE--GSQEMTEQF--QQC
F-----EESIIEEFLQQAPPPAV----RKLDAQE--HAEETPNQST---ELRLQQADL--
-------------------------NHLEALGCD-NPGNKNILDTENTRG-EAKELTRNV
KMGDPLQAYRLISVVSHIGSSPNSGH-YISDVYDFQ----KQAWFTYNDLRV-------S
EISETKMQ-EARLHSG---YIFFYMHNGIFEELLRKAENSRLLSTQAGVIPQGE------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPSRGSIKTAAGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENXXXXXXXXXXXXX-X-XXXXX-XXXXXXXXNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSPGSTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPHNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPLSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKSPFTLGWSAHMAI-SRPLKACQMVNSCITSPSTPSX----XXXXXXXXXXXXXXXXX
XXXXX---------XXXXX---XXXXXXXXXXXXXXX--XXXXXDSKSCRLEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENSEPVETEKPK-TIT--EPDPATFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SVLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSLEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------TSPHKVHGFVQTWNK----RTGSSKLK---------EPITETVEREKDIQLIF
MFQGGKPIDIN------I-LQCFRHYGERQNGLYLTFWKKN-LCLGKLSRTHTERLQILL
DIIHQNKHQWP-IKSESYWGVMESM----NGYTEPD-KT---------------------
PSSNVCRVPSAETFTTEEGRGTTF---------------------PQQ---L--LGKSP-
MFAKQGLPEKKDRKRKTTLSSSL-D-TDEGF-LEEN-ESVPNK--KFKKD----------
---SL---KDLEKDGSSKHGPSLRTAS-----------PGNSPLDE-----TVL-SPQSV
SDK-SLLLPSVPE---------------------RAQD----------DPQHDQDQLCLD
SHPEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNSILQSL-YAIPSF-ADGLLGQGIPWENIPSDVL-IMP
L-SMLLALKDICNLETSQDLLRDIKNAISAV-AEIFSGNMQN-DAHEFLCQCLDQLKG-D
FEKVNTIWKTRREAGDENSPPEL--FAGDAA-TKVFVCPVAS-NFEFELQD-YVICKACG
QVV-VVIEPGNCIS-INLHPKP-KASPL-SLQ-NCFDLFFTTEEC------------ERL
CEMCN-HKKAVVMHKFGRLPRVFIVHLKRYSMS-DTYALMKDDQQVLIPKYLSLSSNCNE
DTRPPLPLESNAPVLD-PEVLNLTQEVISERVSPCTSSV----K-------LTWQSSD-S
SVLHVAPDEDAEQN--------TPQRIWQAR--PKEQQQSDLASGS---NLES----KLG
NARDREVREMEMLAAASVMDQGDISLLMICEDESNPINN---PDRGLEE-VY-----CQE
EPENPEPKDNEKTS-TLV--ELDFDHVSESSKDLCDYEKHKISE--GLRGVVEQLH----
------------------------------------------------------------
-----------------------------------ESVTKDIVGMEKTIA-KVKEPKGSM
QMGDALHSYRLISVISHIGNSPCAGH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTSQQEEVFLPGE------
------------------------------------------------------------
--------------------

-------MAALMVRGFVQIWNK----KTGMSKSK---------EAFIETVEGKKKVKLVV
YFHIGE-CKT-FQLSNNIKNMIFRSYGKKQNHLHLTFQNNNFLFIEKLSSRDAENLKMFL
ERIHQNNLQTR-IRPDNEKSVFAST----TIQKSVN-KT---------------------
SFNKMYRKSSSRSLEKGKRNGTPD---------------------LKEMPLF--TSTSS-
TFIYKELLKNGYGKRKRVLSTDS-E-MIKNF-LKEI-ISLRKK--ISKTNPFRYISHSEK
KELRL---KVLKQNKKFKVGSSLKIRS-----------TGNPYLDGAEFHHIGL--LQRL
SEKLYLAFLSERN---------------------FGED----------DPEWDKFKMTFH
LYPE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KL-WQGLP--NLGNTCYMNAVLQSI-FSIPSF-ADDFLSQGFPWGKIPLDAL-SMF
L-VQLFVLKDIYNIKVKEKLLVSIKKAISAV-AEIFSDNRQN-DAHEFLGHCLDQMKE-N
MRKFNTIWETKSESKERNSPQQV--SAGSAA-TKVVICPITT-NFEFELLR-SITCKACG
QVV-LKTEVSNYLS-ISLPQGV-KTPPS-SIQ-SSFDLFFEAEEL------------EYE
CEKCL-HRDSVAVHKFSRLPRVLIVHLKRYSFN-EFWSFRKDDQEVVISKYLKLSSHCDE
STKPPCPLSNNAHIRD-FQLLKIFQEMNSKTISSSTRSK----K-------LSSKSKA-S
LPPHIGSDKECKPQ--------KCHIRHKGS--SGECLG-KY---SDLNIIES----ALI
NSGDVAIIAKELLA-DLLMDLDDDSHS----LKGEPTSS---PDTS------------QE
VHRNPKRKKYKRTN-MFV----DFEGIIKTTEDFYKNKKPRSLS-ERFHKVAEQT--YQY
E-----KMRVYEQALWTALLQSL----PKPLAQR--YT-ENLRKTT---ELSFQGTNV--
-------------------------NSPRALGSRKTRRNKDCLDTKETGP-EAKKPKRNA
KMGDR-NAYRLIGVVSHLGKTPDGGH-YISDTYDFE----RQVWFTYNDLQV-------S
NIQEEAMQ-EARLRSG---YMFFYMHNEIFEELLERKDKSQPQSKEARETPQE-------
------------------------------------------------------------
--------------------

-------MAPLRIHGFIQIWSK----KTGITKSR---------EVFIETVEGKKETSLVV
IFNSGEFIRV-FQLSNNITNVVLRHCGERQSCLNLTLKNNSSLFIDKLSRRDAEQLKMFL
DIVHQNEFQSP-MESDSDWRVFDSR----NTRKEID-KT---------------------
PFHKVCDMP---------SY--------------------------GKMPSL--ISKSP-
MLVTTGLLENQGGKGKRMQSSCL-E-MSEGL-WEEN-NPILNK--KLKTNSFKYVSGIGK
KPLHL---KDPKRDRNSKYGPSCKTI------------SANPNLDK-----ALH-SVQLL
SSKSSLEFRSGLM---------------------SSQN----------DPGCNESQVPLD
SHPEQL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYVNASLQSL-FAIPLF-ADDLLKQGVPWEKIPFGAL-VMD
L-NQLLVLKGVCNVETKKGLLVNVKSTISVV-AETFSSNIQN-DAHEFLGHCLDQLKE-D
MKKLNTTLRTERELGDENSSPQR--YAGNAA-TKSFVCLAVA-NFEFELQC-SIICKACG
QVV-LKAEPSHYLS-INLPQET-KPLPF-SIQ-NCFDFFFRAEEP------------ECN
CEKCK-HKSSVAKHKFSRLPRVLIVHLKCYNFS-DVWL-VKDNQRVHVPKYLSLSSHCND
NTKPLLPG-SNAPTGD-SKVLNVSQEMISEIISPSTPSV----M-------LISESSE-S
LVLQIPSEKEAKPQ--------NFRKICEGS--SQEQQQRDLEKCST--AVES----ELV
NSGDGTVSEKELLAADS-MDQGDISLPMICEDAGKPTSS---PRTGLVE-IH-----LQE
VADNPELKKYEKTN-AFV--E----SVTESTEDFCEDKETWIPE--RSEGMAEQLQHD--
-------GKRIYEFLQGASPVAEWL---QQPRVE--HIEKDLN--------SPQKANL--
-------------------------NSLGALGSDKNSGNKDILDTENTEA-EAREPKRNT
QMRDPLHAYQLISVVSHLGHSPHSGH-YISDVYDFQ-----RAWFTYSDLRV-------S
QIEKSVMQ-EARLCTG---YIFFYTHNEIFEALLGKAENSQVLRTEVGKILQEKEED---
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MISLKVHGFIQIWSR----QTGMTKLK---------EALIETVQRKKEIKLVV
TFKSGKFIRI-FQLSNNIRSVVLRHRKKRKSHLRLTLKNNVFLFIDKLSYRDAKQLNMFL
DIIHR

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NKLQQP-MKPDDDWSVFESR----NMLKEID-RT---------------------
SFYNICKT--------------PF---------------------PQKMPLF--MSKSP-
TYVKKGLLENQGGKRKDILSSDL-E-MNDDI-LKEH-NLVSNR--KYKTDSFKYIQSYGN
NPSSL---EDSEKDRNLELWPSFNS-------------NGNPNLDE-----TLL-ATQIL
EAENSLTFPLEPE---------------------HSQY----------DPRCNEAQVPLD
SLSEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAILQSL-FAIPSF-ANDLLAQDVPWEYIPFEAL-IMT
L-TQLLALKDFCSTEIKKELLGNVKKVISAV-AEIFSGNMQN-DAHEFLGQCLDQLKE-D
MENLNAILKTGKEHGDENSSPQM--HVGNAA-TKVFVCPVVA-NFEFELQL-SIICKACG
HAV-LKVEPNNYLS-INLHQDT-KSLPM-SIQ-NSLDLFFREEEL------------EYN
CEMCK-HKSCVAMHTLRRLSRVLIIHLKRYSFN-DAWLLVKNNEQVYIPKYLSLSSYCNE
STKQPLPLSSNAPMGK-CEVLEVTQEMISEIISPLTPSL----K-------LTSESSD-S
LVLPMEPEKNADLQ--------SFQRDCGEA--SQEQHQRDLENGS---ALES----KSV
NFRDRAFGEKKCPVADSLMDQGDISLPMICEDGSKPLSS---PDTRLLD-VH-----LQE
MPQHPELQKYEKTN-TFV--ELDFDSITESTNSSYECKENRFPE--GSPRMSEQL--QQC
I-----EKSIIEELLQQAPPPGV----RKLHAQE--HTEETLSPPT---EFRLQKADL--
-------------------------NHLGAFGSD-NPGNKDILDTENTRD-EVKELMGNM
KMGDPLQAYRLISVVSHIGSSPNSGH-YISDAYDFQ----KQAWFTYNDLCV-------S
EISETKMQ-EARLHSG---YIFFYMHNGIFEELLRKAENSRLLSTQAEVIPQGE------
------------------------------------------------------------
--------------------

-------MTPLKIHGPIRVRSI----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNAGGIPRT-FQLSHNIKNVVLRPNGAKQSRLILTLQDNSYLSIDKVPCKDADEMRLFL
DAVHQNRLHTA-MKPSQGSGSFGGVLGNRTAQKEVN-RQFSYIENQTSSKKVNLESKDDT
TFRKVLGNPGRGST

PF00443 // ENSGT00440000033542_0_Domain_1 (195, 1164)

KTPTGSVMTG---------------------TRINTSLT--STPS-
TPLRTGLLENRNKKRKRMSSTQS-E-MNEDY-PKENDSSPXXX--XXXXXXXXXXXXXXX
XXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----TSV-SSQTP
SAKRSLGFL--------------------AQPAPLSVKKLRSNQD---YTGWNKPRVPLS
THSQQQ-LQGXX--XXXXXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXXXXXXXXXXX--
RFAHLLAKKDVCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSPGRT---PDDFATTRIYTCPVIT-NLEFEVQH-SIICKVXX
XXXXXXXXXXX-XX-XXXXXXX-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXGLILHKRYSFNVA-------------LSLNNKVGQQVVIPRYLTLSSHCTE
STKPPLTLGWSAHTAI-SRPLKASQMVNSCTISTSTPSR----K-------YTFKSKS-S
IGFSIDSDSEDELLKRSVA---LSQRLFEMP--GREQQE-DLEKXXXXXXXXXXX-XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXX-XX-----XXX
XXXXXXXXXXXXXXXXXX--XXPASFTE-ITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----ER---------------------------EREEEEL--QQALAQ-SLQEQXXX-
XXXXXXX-XXXXXXXXXXXXXXXX-XXXX-XX-XXXXXXXXXXXXXXXXX-XXXXXXXXX
XTGNLPHSYRLISVVSHIGSTSSSGH-YISDVYDIK----KQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKDIFDELLETEKASQLLSMEGGRTTRPAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLIV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-VKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGNLETKDDI
PFRKVLGNPGRGSIKTVAGSAMAV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRVL-SGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGGTNLDR------TNVSSQTS
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDVCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASHMVNSCITSPSTPSK----K-------FTFKSKS-S
LTLCLDSDSEDE-LKRSVA---LSQRLCEMAGSEQQQ--EDLEKDTKLCKIEPDK-SELE
NSGFDRMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENSDTVETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEMGKATRQAS-----
------------------------------------------------------------
--------------------

-------MTPLQIHGFIKIWSK----NTGMTKLK---------EAFIETVEEKKEIKLVI
LSKSGGITKV-FRLSNNIRSVVLQHCEKRKSHLCLTLQGNI-LFIGKLSFQDAEQMKMFL
DVVRQNKLQNS-MKPDDDWNIFESR----NTQKEID-KT---------------------
LSYKNRYKP---------SY--------------------------RKMPLL--MPKSP-
TLFNKGLLENLSEKRKKTLPSDL-E-INEDF-LKENNNLTLNK--KFKTDSLKYERSNWK
EPASL---KDLEKGRNSILGSSFKTDS-----------NINPNLEE-----TVL-STQTF
SGKGGLAFSSEKE---------------------HSQN----------DPSGTEAQVSFD
PQPEKL-CE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAVLQSL-FAIPSF-SHDLLMQGLLWEKIPVDAV-ILP
L-RQLLTLKDTCDRKIKEELLINVKYAISAV-AKIFSGNAQN-DAHEFLGQCLDQLKE-D
IKKLNDVLKTEREPRNENSSPQM--YAGNTV-TNVCVCPVIA-NFEFELQL-SIICKACG
HTV-LKTEAGNYLS-INLYQEA-KPLSL-SVQ-HFFDMFFQAEEL------------VYN
CEMCK-HKSSVAVNTFSRLPRVLIVHLKRYSFN-DAWSLVKNNQHVHIPKYLSLSSYCNE
STKSPLSLSNNVPVWP-SKVLNASQEIISKIISQLTPSV----K-------STSESSD-S
LVLQFAQDKNADLQ--------RFQRKCEEV--NQRYHHKDLQNGS---KLES----KEV
NSEDKTVSEKELAMADSVMDLGDTSLPMTCENRDKLIGS---QDTDPAE-TH-----LQE
TSENPEFNKCEKTN-TPI--ELDVDTVMESTSGFYEYKGSRILG--QSQGMAEEF--RQN
I-----ETRITEEFLQQVSPPSAG----KPDTQE--HAEKALDRST---EIKPQKTNL--
-------------------------NSLGELGSDENPGNKAILEMENTEA-EAKEPNRNV
KTRDPLQVYRLISVISHLGSSQSSGH-YISDAYDFQ----KQAWFTYSDLWV-------S
EIQEPLIQ-EMRHQSG---YIFFYMHKEIFAALLEKAENSQPLSTQEGVNLQGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MDPVLIHAQVQLWSA----KAGMSKSR---------NAFIETFIGKREVKLIL
YFSTGK-IKA-LQLYNNIKSVVLRTYGEDQNYLHLTFKNNDFLFVEKLTTMDARRLKRFL
DKIY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QSNLRAA-RRSG-ERPGDPST----SAQ-ELS-SS---------------------
PP-EGHLKASSACFESAKESEMCL---------------------FRQLPLL--PPSSA-
SLNAVGLLESQFMKRKRFF-LGA-E-K----EK-QN-LKGSTR--EFETNLVVSISNEKG
KERGV---RAVE-ISKAGFGFPFETNY-----------PEEGSVNV------RD--LNDL
ITKLFSPLLFETH---------------------YIEN----------GLDWHEYMETFL
LDPEKS-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSIPLF-VNDLFNQGFPWIKPPKDDF-NMR
L-MQLLVLKDIYNARTRQKLLIGITKALPIF-GEVFAADRQN-DAHEFLSLCLVQLKE-T
VQRVNMMWQSENESGDYYLLREI--FANYTSINRTPVCPVTN-NFEFELLS-SIFCKACG
LTV-FKREPSRYLS-INIPQGM-KDQNM-SIQ-SSLDLFFRAEEL------------EHR
CERCL-YNKSVALHKFGRLPRVIIVHLKRYSFS-ESRIMNKDEQHIVISKYLRLSCHCNK
NTKPPQPLLPNEHVKN-LDLLRPLEELGSEILKLSSNSG------------RTSRSKV-F
PTVNIRSDKELEVQ--------NGKRVSEVS--SGSAQQEDPGKGA--NVVRS----ELT
N-----------------------------------------------------------
--ETETI-KHEKEY-VLS--DLDSGSISEE----------------RSQKC-QEA--EKC
N--------------KEALPQSC----PKPSSQE--QT-ENLGKPA---VSHTQNGSL--
-------------------------SSQGSSDSSKSPGCNDVFD-K-AKPTSKVEP-QKL
NQKED-NIYRLVSIINHIGNSPNGGH-YINDAFDFR----KQSWFTYSDLQV-------T
GIQEDLVY-KARLSTG---YVFFYMHNDIFEELLAKEAWSTSTSKG--------------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTATGSGITV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLIPLQSSSFYGSRTGSKDYTSGSTNLD------RTNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSS-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----N-------FPFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRICEMSGCEQQP--EDLEKDSRSCRVDPDK-SELE
NSGFDGMSEEELLAAVLEMSKREASPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENQDPVETEKPK-PVT--EPDSASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

---------------------------------R---------EALVETVEGEKEISLAG
VFNAEGFIRV-FQLSNNITSVVLTRCGKRQGCLHLTLQNNSCLFIDKLSHRDAEQLKAFL
DAVCQNKSQPP-MKHNRDWGVFGGR----NTQKETD-KT---------------------
PSHQVRDKPCGAPSNTEKANETLS---------------------PPKMTLF--K--SP-
TLARTGLLENQGTKREKMLSPGR-E-MNEGS-LRES-NPEV-N--KLKTNSFEYTESNRD
ELLHS---EGQEKLRNS--------TC-----------EENGSLAQ-----TVV-LIQAL
SCKTGSEFPSEQI---------------------YSHD----------DLRWDD----LD
THPE--FW

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 789)

QGFP--DLGNTCYMNAVLQSL-SVIPSF-ADDLLM-------MPFVAF-ITC
L-TQLLALKDICNPEGKKELLVNIKNAISAV-AETSSGSVQC-DAYEFLGCCSEQLKE-D
MEKLTTTLKTERKTGVEIHRCRC--VDGAAC--QTFVCPVVA-NFEFELQC-SIVWKACG
QVV-LKTEPSHYLPCINLPQEM-KLQPS-SIQ-NSFDLLFRAEDL------------EYS
CHECT-HEISVAMHKFSKLPRVLIVHLKCYSFN-DAWLLVKENQPVAIPKFLNSSSHCSE
STKLAFPTAANTPPGD-SEMLEVSPEVFSEILAPSSPSK----K-------LISESSD-S
LA------KNAEPL--------MFQKIVGGS--SQERQQRDLENGPEWNKAAS----G--
------MAGKELPAADSGM----------------TMHQ---PTPSLRE-AQ-----LQE
APEDQTFRDLRRQG--IR--RADAGGVMESTEAFYQAHENRIPE--RSQGVAEKL--PKC
N-----RKRIIQELRQELGAQEC--------------AGRDFQ--------DHQKDLG--
-------------------------DSLGALGSDANPGILDW---ETQEL-KPKGKRKC-
-LPAPL-------CRQPSREPPDSGH-HISDVGLSE----AGSHT---MACW-------N
QKSESVMQ-EAGLHTG---CVFFNVHDEISQALLRKARNSHLGKKEVSLFKKGK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPVRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLNGA-MKPSQGSGSFGAILGSRTSQKEIS-RQLSYSDNQAPAKRGSLETKDDI
PFRKVLGSPGRGSMKAVAGSGIAI---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRVLSTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEYSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAV-SRPLKTSQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKHSVA---LSQRLCEMSGSEQQQ--EDLEKDSKLCRIEPDK-SELE
NSGFDRMSEEELVAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-NFYK---------IL---SLYSSEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQTLSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------MTPLKIHGPIRVRSI----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNAGGIPRT-FQLSHNIKNVVLRPNGAKQSRLILTLQDNSYLSIDKVPCKDADEMRLFL
DAVHQNRLHTA-MKPSQGSGSFGGVLGSRTTQKEVN-RQYSYIENQTSSKKA-SLESKDD
TFRKVLGNPGRGSTKTPTGSIMSG---------------------TRIHTSLSS----TS
TPLRTGLLENRSEKRKRLLSSGS-E-MNEDY-PKENDSSSNNK--AMTDPSRKYLNNSRE
KQLSL---KQTEENRTSGLLPLQSSSFYGSRAISKDYSPGNSNLDR------NNVSSQTP
SAKRSLGFLSQPAP-------------LSVKKLKSNQD----------YTGWNKPRVPLS
THSQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1105)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-ISR
RFAHLLAKKDVCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPLSGEENSP--GRTSDDIAA-TRIYTCPVIT-NLEFEVQH-SIICKVCG
ETV-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKSAIVTHKFNRLPRVLILHLKRYSFNVALSLNNKVGQQVVIPRYLTLSSHCTE
NTKPPLTLGWSAHTAI-SRPLKASQMVNSCTISTSTPSR----K-------YTFKSKS-S
LGFSIDSDSEDELLKRSVA---LGQRLFEMPSKEQQ---EDLEKGSKKCKMESDK-SELG
NSGFDGMSEDELLAAVLEISKKEASLTLANEDDDKPTSS---PDTGFAE-DD-----MQD
MPENLESLEAEKSK-API--EAGPASFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEEELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDGMGSDDDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGK-RSFELSCSR--SNGELRASYNNLPL-------L
EFYKLIVL-KKKKKKGFSTPFSPYSSRDIFDELLETEKASQLLSMEAGRITRPAL-----
------------------------------------------------------------
--------------------

--------SPHKVHGFVQTWNK----RTGPSTLK---------EPITQTVEREKDIQLIF
MFQGGKPIDIN------I-LQCFRHYGERQNGLCLTFWKKK-NFVLALSRTHTERLQILL
DIIHQNKHQWP-IKSESYWGVMESM----NGYTEPD-KT---------------------
PSSNVCRVPSAETFTTEEGSGTTF---------------------PQQ---L--LGKSP-
MLAKQGLPEKKDRKRKPTLSSSL-D-TNEGF-LEEN-ESVPSK--KFKKD----------
---SL---KDLAKDGSSKHGPSLRTAS-----------PGNSPLDE-----TVL-SPQSV
SDK-SLLLPSVPE---------------------RAQD----------DPQHDQDQLCLD
SHPEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNSILQSL-YAIPSF-ADGLLGQGIPWENIPSDVL-IMP
L-SMLLALKDICNLETSQDLLRDIKNAISAV-AEIFSGNMQN-DAHEFLCQCLDQLKG-D
FEKVNTIWKTRREAGDENSPPEL--FAGDAA-TKVFVCPVAS-NFEFELQD-YVICKACG
QVV-VVIEPGNCIS-INLHPKP-KASPL-SLQ-NCFDLFFTTEEC------------ERL
CETCN-HKKAVVMHKFGRLPRVFIVHLKRYSLS-DTYALMKDDQQVLIPKYLSLSSNCNE
DTRPPLPLDSNAPVLD-PEVLNLTQEVISERVSPCTSSV----K-------LTWQSSD-S
SVLHVAPDEDAEQN--------TPQRIWQAR--PKEKQQTDLASGS---NLES----KLG
NARDREVREMEMLAAASVMDQGDISLLMNCEDESNPINN---PDRGLEE-VY-----CQE
EPENPEPKDNEKTS-TLV--ELDFDHVSESSKDLCDYEKHKISE--GSRGVVEQLH----
------------------------------------------------------------
-----------------------------------ESVTKDIVGMEKTIA-KVKEPKRSM
QMGDALHSYRLISVISHIGNSPCAGH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTSQQEEVFLPGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MAPIKIQGLVQIRSKNRNRHTRASQWK---------EAVIEIVERKQKVTMVF
SFKLEKRKRV-FQLGNNVAGVVVSCCEMGLHCLYLTLKGDTSLLIDKLSSADIEQLKAFL
DLA

ENSGT00440000033542_0_Linker_0_1 (124, 430)

HLSDTQDP-DDPMRKQEFLEGG----H------------------------------
PFCKKHPEPVCGSSETAQEREAPL---------------------PGKMPLS--LAKSTS
RYAKKDKAEKEIKKRKRMAAPSV-D-VEEEI-LTEF-SPEPQK--KYKICNPRSKRGKGE
KPMAS---REQEKPTNWKLETSLMASA-----------RRKTNLDD-----TTVLSTQTL
AEERS-----GPK---------------------FNQE----------PPVCAEIQLPLD
TYAKQLNRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWDKVSCDDL-IKP
L-SQLLVLKDIRDVEIKGQLLMTVKKTISTV-ADTFLGDEQN-DAHEFLSQCLEQLKL-N
MEKLNAMCCSERENEA-------------AS-SRRFICPVAA-NFEIELHS-SIVCEGCG
EAT-LNTEVSNYLS-VDLPQGT-KDHPL-SIQ-KSLDLFFTPEKI------------EHN
CENCK-NKNSVLRYTWRRLPRVLIVHLKRYHFT-ANRMLVKSQQPVEISKYLTVASHCNE
NTKQPFPVTTRNSNGD-FDVPGV-EGTMHEIFGHSIPSI----Q-------PTSVSID-F
TVLQVGSNEDAEMQ--------NFQIMC------DDQQQLGLEGVS---GIDP----DLL
KTEKWMLCENTSPSWDS----------IICE----PISI---QDLGLRE-KG-----LQK
LPENPDSKNYKKIN-VYG--NPNHHTIIEICNNFCDLKEQKFLE--DTQEIGKQL--LQQ
H-----GKRIQKELLPWALPQSV------RGTQE--DMGKNMNRYS---EMVDPKIDA--
-------------------------DFLSALGYTESPRV---AGMD-------HSDAANE
AMAEDPQNYRLVGVVSHFGSSQDSGH-YVSDVYDFQ----RRAWLLYSDVQV-------F
EIPEALIQ-ENRLHTG---YIFFYMQNEIFEWLLKKASECRLLSTPKDEKRTMD-LFSTL
LNGFTYLLEES-------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKESKVSLVV
HYNTGGIPRI-FQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXTPSKRGSLETKDDI
PFRKVLGNPSRGSIKTTAGSGIPV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSXXXXXXXXXXXXXXX-XXXXXXXXXXXXX-----XTNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRYNQD----------YSGWNKPRVPLS
SHPQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1147)

QQ-LQGFS--NLGN-CYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-L-R
RFAHLLVKKDVCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPCNLSWNAHMTV-SRPLKASQMVNSCITSPATPSK----K-------FTFKSKSSS
LAFCLDSDSEDE-LKRTVA---LSQRICEVSCGEQQQ--EDLEKDSKLCRLEPDK-SELE
HSGFDGMSEEELVAAVLEISKTDTSPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPEPVETEKPK-AIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQREDDDIKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSSSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDXXXXX---XXXXXXXXEIFDELLETEKNSQAPNMEAGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MDSQLIHAQIQMWCA----KAGISKPR---------AAFIKTIMGKQEAKLQL
CFSTGK-IKA-LQLKNNIKSVVLRSYGKDQNYLNLTFKNNDFLFVENLTTIYARQLKKFL
DRVH

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QRNLRAF-RRNNKERSGGPST----STQ-ELG-VS---------------------
LRREVRAERNSKCFKSAKKSGAPV---------------------LDEMPLS--SSSST-
TPNSAGVSEKQLVKRKRSS-RNS-E-K--KATE-NI-RQGSSK--KSEAKSVVSVHDNKE
KERDL---REAE-KSKPGFGFSSETNN-----------PEESDLSV------RN--IHDL
LTKLFSPFLLEPC---------------------SMAK----------DIEWHEYIKRLL
LYPEKA-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CAVPLF-VNELFNQGFPWIRPPRDDF-NMR
L-MQLLVLKDIYSAKARETLLINFTKVLPQF-GEIFTAYRQN-DAHEFLSLCLVQLKE-A
VQKLTVLWQAENESGRNNLLRQI--FANHDIIDKIPFCPVAN-NFEFELMR-SIFCKACG
LVV-HRKEPGNYLS-ISIPQGL-KGLNL-SIQ-SSFDLFFKAEEL------------EHR
CERCM-HNRSMAVHKFVLLPRVIIIHLKRYIFT-ESQIMKKDEQHVIISKILKLSYHCNE
NTKPPQPISQNAHVKD-FDLLKPLKELGSEILKESFHSM------------MTSGPKD-S
STGNKSSNKESEAQ--------NVRRVSKVL--SGKVKQEDQGKGTTQNVSGS----KLT
K-----------------------------------------------------------
--ETKKHKKRKKAC-TSS--ELDSGSFK------------------RSLKY-QQV--QKH
Q-----EQRNGKQTSREAVTQSH----PKPSSQE--QI-GCFSKPA---ESHTQSGNV--
-------------------------KLQGSLDSSKNLGSKDSSGKK-TKLRGKVEP-KTV
EPKGD-NYYRLINIISHIGSSPHGGH-YINDAFDFR----KKNWFTYNDPHV-------T
KIQEELMQ-KARLSTG---YVFFYMHNEIFEDLLAKEAQACKMS----------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRVRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGTKQRRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MK-PQGSGSFGAILGSRAPQKETN-RQLSYSDHQASSKRGNLETKDDT
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPP----LTLTS
TPLRAGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--ALTDPSRKYLTSSRE
KQLTL---KQAEENRTSGLLPLQSSAFYGSRAGSKDYSSGGTNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRMPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFANLLMKKDICNSETKKELLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DSSI-TKVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWNAHMAI-SRPLKASQLVNSCVTSPSTPSK----PFKNNYMKFTFKSKS-S
LTLCLDSDSEDE-LKRSVA---LSQRLCNPSGIEQQQ--EDLEKDPKLS---PDK-SELE
NSGFDRMSEEEVLAAVLEISRRETSPVLCREDDDKPTSS---PDTGFAE-DD-----LQE
MPENLDAMETEKPK-TVV--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWM--QQY
DM----EQEREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKSSQAFNMDVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MAALFLRGFVQIGNC----KTGISKSK---------EAFIEAVERKKKDRLVL
YFKSGK-YST-FRLSDNIQNVVLRSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFL
DRVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKVQPP-VRPGKGGSVFSST----TTQKEIN-KT---------------------
SFHKVDEKSSSKSFEIAKGS-GTG--------------------VLQRMPLL--TSKSS-
TLTCGELSENQHKKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADCSRCVSYNRE
KQLKL---KELEEDKKLECESSCIMNA-----------TGNPYLDD-----IGL--LQAL
TEKMVLAFLLQQG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-ARLLFLKDTYNIEIKEMLLLNLKKAISAV-AEIFHGNAQH-DAHEFLAHCLDQLKD-N
MEKLSTIWKPKSEFGEDNFPKQV--FADDPD-TSGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQRI-KAHPS-SIQ-STFDLFFGAEEL------------EYK
CAKCE-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFCALKKNDQEVIISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGNISVSWPAT----K----------ESKD-I
LAPHIGSDKESEQK--------KGQTVFKGA--SRRQQQKYLGKNSKPNELE------SV
YSGDRAFIEKEPLA-HLMTYLEDTSLCQFHKAGGKPASS---PGTPLSK-VH-----FQT
VPENPKQKKYVKTS-KFV----AFDRIINPTKDLYEDKNIRIPE--RFQKVSEQT--QQC
D-----GMRICEQAPQQALPQSF----PKPGTQG--HT-KNLLRPT---KLDLQKSNR--
-------------------------NSLLALGSNKNPRNKDILDKIK--S-KAKETKRN-
DK-GD-HTYRLISVVSHLGKTLKSGH-YVCDAYDFE----KQIWFTYNDMQV-------L
GIQEAQMQ-EDRRCTG---YIFFYMHNEIFEEMLKREENAQLNSKKVEETLQKE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MATLMAHGFVHIWSK----NVGMSKPK---------EAYIGKVERKKNIRLLV
YFSTGE-STT-FQLTNNIKNVVLRSYGGKQNHLHLTFQNNSFLFIEGLSSADAEELKMFL
DGFPQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

N-NQPS-MKPVKDGGIFACT----TTQKEIN-KS---------------------
SSHEICSKSSSGSLETGEGHGTAD---------------------LQQKPLC--ASKSS-
TLTCNDLPENGQEKRKRMLSSGS-G-MGGKF-LQKN-SSVRDQ--KFETNLLRYVSHNRK
KKLRL---K---NKKKLAFEHLFETNS-----------TGNPYLEG-----VSV--LQVL
CEKIYLAFLLEAK---------------------YSAD----------KPEWDRLKMTLD
LYPDKL-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNAVLQSL-FSIPSF-ADDLFSKDSPWGKVSLDAL-SIC
L-AQLFVLKDIYNIKIKERLLASLKKTISSV-AEIFSDNVQN-DAHEFLGHCLDQMKE-N
MGKLNTIWKAKIESEEENPAQQI--FPGSAA-TEVLVCPIIN-NFEFELLR-SITCQTCG
HVV-LKTEVNNYLS-INLPQGT-KSLPL-SIQ-SAFDLFFGAEEL------------EYK
CGKCK-HKSSVAVHKFSRLPRVLIVHLKRYTFD-EFWSLRKDDQEVVISTHLDISSHRNE
TTKPPPPVSKNVLTRD-FQILKVFHSMKFGNFFLSTPST----K-------PTLASND-S
LIPHIGPDKESEPQ--------KCQIPCEGS--SNGEQKEDLGKCPKLNITES----ELV
NLGNGAVIEKELLAAGLMMDLEATSLSQIQKDEGKPTSG---LDRCLAE-VY-----LQE
MFENLKQKKYETTN-TRV----DFKSGTETTEDTYKHEKNRIPK--EFQKPTKQT--QQD
E-----WMKIYEQALRQALLGAL----LKTRTRW--YA-KNLRKPA---KLRLQETKA--
-------------------------NSLGAPGSNKNPGNKECLKKEKSET-EATKPKRSG
KMSDL-DSYRLIAVVSHLGKTPNSGH-YISDAYDFE----RQAWFTYNDLQV-------L
SIEEDLMQ-EARLCTG---YIFFYMHNDVFEELLKREENFQSRNTKARKTAQEK------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLIV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-IKPSQGSGSFGAILGSRASPKETS-RQLSYSDNQVSSKRGSLETKDDI
PFRKVLGNPGRGSVKTVAGSGVAV---------------------TRSVPS----LTSTS
SPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTPGLLPLQSSSFYGSRAGSKDYAAGGTNLDR------TNVSGQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPFNAL-L-R
RFAHLLIKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFALSWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRFCEMTSNEQQQ--EDLEKDSKLCRIEPDK-SEME
NAGFDRMNEEELIAAVLEISKRETSPSPSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTIETEKPK-TAT--EPDPASFAEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALVQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTAA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQSWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSVEAGKTTRQVS-----
------------------------------------------------------------
--------------------

-------MATLRVHGFVQIWNR----KMGMSRTK---------EAYIETVERKKRIKLVV
CFTTGE-SVT-FQL-NNIKNVVFRSYGEKQNHLRLIFQNNSFLFMERLYFRDAVQLKMFL
DRVHQNNTQSS-VRPGKDGDIFARK----TAPKEIN-KN---------------------
SFRKAGKKPRSRSFQIGEGTRTPDHKKRKPSSRSFQIGEGTRTPDHQKRPSS--ASKSS-
KLHCKDLLENRYGKRKRMVSSGS-E-MTGNT-PKKT-NSVGKM--KSQTNPLRHVSHDEK
KKLRL---RVLKKKKNVEFEALIKTTS-----------PGKPQLDG-----TGL--LQML
TEKLYLAFLLAPK---------------------YNAN----------DPEWDKLKMTFD
FYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNAVLQSL-FSIPSF-ADDLLSQDFPWDKIPLGAL-SMC
L-AQLFVLKNIYNIKIKERLLVNIKKAISTV-AEIFSGNIQN-DAHEFLGHCLDQMKE-N
MGKLNTIWKMKIESKEDNTAQQV--FADSAA-TRVLICPVIT-NFEFELLR-SIICQACG
QVV-LKTEVSNYLS-INLPQGM-KALPL-SIQ-SAFDLFFGAEEL------------EYK
CEKCQ-HRSSVAVHKFSRLPRVLIVHLKRYIFN-EFWSLRKDDQEVVISKYLKLSSHCNE
STKPPLPVSKNVHNRD-IQVLKVFQKLSAERLQPSALSQ----K-------LTSASRV-H
RVPHAGSDKESKPQ--------KSRILYEGS--RREQQKKDLGKRSRLNGTDS----KLV
NLGDGIVIEKEVLAAGLMIDLEQVSPYLICDNEGKPRSG---PETHLAG-IH-----LQE
ASENRKRKKYKKTN-TLV----DFESVADTVEDFYDGKKNRISK--ESQKLAEQT--KQQ
E-----RVRLYEQALQQALLQAL----LKPHVQW--YT-QNLRRHT---DLSLQGANV--
-------------------------NSLGESSSNKSPGKKQALH-TKTET-EAKTPKGSA
EMRDL-YAYRLIGVVSHLGKSPNSGH-YISDAYDFE----RQVWFTYNDLQV-------S
SIQEALMQ-EARLCTG---YIFFYMHNEIFEELLKREKNSQSHRAETRETPQEK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPVRIRSM----QTGITKWK---------EGFFEIVEKDNKVSLVV
QYNTGGIPRI-FQLNHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEDMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRHTA--NKTPQGSGSFGAILSSRASQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGHPGRVPIKTVPGSGIAI---------------------PRTIPSLSP------
TSLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGSTNLDR------TNVSSQTP
SAKRSLGFLPQPSP-------------LSVKKLRYNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDVCNSETKKELLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVLGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKSALVRHKFNRLPRILILHLKRYSYNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWNAHTAI-SRPLKASQMANSCITSHSTPSK----K-------FTFKSKY-S
LALCLDSDSEDE-LKRSVA---LSQRLCEISGNEEQQ--EDLEKDAKLCKTESDK-SELE
NSGFDRMSEEELLAAVLEISKREASPTPSHEDDDKPTNS---PDTGFAE-DE-----VQE
LPENPDTVETEKPR-AVS--EPEPASFTEITKDCDENKENKTPE--GSQGEIDWF--QQY
DM----EHEREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNTQALSMEVGKTARQAS-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEVVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAG-MKPS-QSGSFGAILGSRTSQKETN-RQLSYSDNQXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX---------------------XXXXXX----XX--X
XXXXXXXXXXXXXXXXXXXXXXX-X-XXXXX-XXXXXXXXNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAASKDYSPGSTNLDR------TNITSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIS-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFNLGWSAQMAI-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKN-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGSEQQQ--EDLEKDSKSCRLEPGK-SELE
NSGFDGMSEEELLAAVLEISKREASPPLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MSENPDPVETEKPK-TVT--EPDPASFTEITKDCDENKENKTPE--GTQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSVGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKISLVV
HYNTGGI

PF00443 // ENSGT00440000033542_0_Domain_1 (68, 1164)

PRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHGA-MK-SQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLEAKDES
PFRKVLGSPGRGPIKTTAGNGMTV---------------------PRTVPSLPSLTSTS-
TPLRSGILENRTEKRKRVLSSGS-E-LNEDY-PKENDSSSXXX--XXXXXXXXXXXXXXX
XXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXX-XXXXX
XXXXXXXXX--------------------XXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XX--XX-XXXXX--XXXXXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXXXXXXXXXXX--
XXXXXXXXXXXXXXX--XXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXXX-XXXXXX---XXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXX
XXXXXXXXXXX-XX-XXXXXXX-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXX-XXXILILHLKRYSFVA-------------LSLNNKVGQQVIIPRYLTLSSHCTE
NTKPPCTLGGSTHTTV-SRPLKASQMVNSCVTSPSTPSK----N-------FTFKSKN-S
LALCLDSDGEDE-LKRSVA---LSQRLCEIT--GSEQLQEDLEKDSKSCRIEPGK-AELE
TPGLEGMSEEELLAAVLEISKRETSPSLSHDD-DEK------------------------
---------------PTS--SPDTGFAEDDIPEMPENPDPVEPE--KPRMATELX--XXX
XX----XXXXXXXXXXXXXXXXX----XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXFNSSLLDSLGSDEDSGNEDVLEMEYTEA-EAEELKRNA
EXXXXXXXXXXXXXXXXXXXXXXXXH-YISDVYDIK----KQAWFTYNDLEV-------S
KIQESSVQ-TDRDRSG---YIFFYMHXXXXXXXXXXXXXXXXVNVEVGKSARQAS-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTATGSGITV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTGSKDYSSGSTNLD------RTNVSGQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGCEQQQ--DDLEKDSKPCRIEPDK-SELE
NSGFDGMSEEELLAAVLEMSKREASPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENQDPVETEKPK-TVT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MAPIKIHGLVQIRSKNRNRHTRASQWK---------EAVIEIVERKQKVTMVF
SFKLEKRKRV-FQLGNNVAGVVVSCCEVGLHCLYLTLKGDTSLLIDKLSSEDIEQLKAFL
DLA

ENSGT00440000033542_0_Linker_0_1 (124, 430)

HLSDSQDP-DDPQGCQDFLESR----H------------------------------
AFCRKHQEPLCGSLNTAQERETPL---------------------PTKTPLS--MSRSTS
RQVKKERVEKEIKKRKRISTPSV-E-VDEDI-LTEY-NPEPQK--KYKVCTPRSRRGKGE
KPMAS---REQEKHSNWKLENSLIASS-----------RRKTNFDD-----T-VLSAQTL
SDERS-----GSK---------------------LSQE----------TPACNEIQLPLD
TYAKQLNRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWEKVSCDDL-IKP
L-SQLLVLKDIRDVEIKGQLLMTVKKSISTV-ADTFLGDEQN-DAHEFLSQCLEQLKL-N
MEKLNAMCSSERENEA-------------AT-SKRFICPVAA-NFEIELHS-SIVCEGCG
EAT-VNTEVSNYLS-VDLPQGT-KDHPL-SIQ-KSLDLFFTPEKI------------EHN
CENCK-NKNSVLRYTWRRLPRVLIVHLKRYHFT-SNRMLVKSQQPVEISKFLNVSTHCNE
NTKPPFPVTNKYDVS-----NSS-EGTMHEIFGHSIPSM----Q-------PTSVSID-F
TVLQVGSNEDSDVQ--------NFQIMC------DDQQQLGLEGVS---GIDP----ELL
KTEKWMLCENASPTWDS----------IICE----PISF---QDLGLRE-KG-----LQK
LPENPEVQNYKKIN-VYG--NPNHHTIIEICKQ---------------------F--LQH
H-----GKRIQKELLPWALPQSV------RDP----------------------KGDA--
-------------------------SSLGASGYPGNSKV---AGSD-------NPDA---
--ADDPQSYRLVGVVSHFGSSQDSGH-YVSDVYDFQ----RQAWLLYSDVQV-------F
EIPEALIQ-ENRLHTG---YIFFYMQNEIFEWLLKKASECRLLSTPKDEKKTMD-LFSTL
LNGFTYLLEES-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIA-----------------------RMIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRAYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDSKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPR-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDSKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKEAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKPSQGSGSFGTILGSRASQKETN-KQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPSRGSVKTVAGSGIAV---------------------SRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGP-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGSNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YAGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPFNTL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPILGEENSP-------DASA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVVIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
FTSCLDSDSEDE-LKRSVA---LGQRLCDVSGNEQQP--EDVEKDSKLCRLEPGK-SELE
SSGFDRMSEEEVLAAVLEISRREASPVLSHEDDDKPTSS---PDTGFAE-DD-----VQE
MPENPDAMETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEATVQ-SDRDRSG---YIFFYMHKEIFDELMETEKNSQAPSMEVGKATRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MAALFLRGFVQIGNC----KTGISKSK---------EAFIEAVERKKKDRLVL
YFKSGK-YST-FRLSDNIQNVVLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFL
DRVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NEVQPP-VRPGKGGSVFSST-----TQKEIN-KT---------------------
SFHKVDEKSSSKSFEIAKGS-GTG--------------------VLQRMPLL--TSK-L-
TLTCGELSENQHKKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADCSRCVSYNRE
KQLKL---KELEENKKLECESSCIMNA-----------TGNPYLDD-----IGL--LQAL
TEKMVLVFLLQQG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-ARLLFFKDTYNIEIKEMLLLNLKKAISAA-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFGEDNFPKQV--FADDPD-TSGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQRI-KAHPS-SIQ-STFDLFFGAEEL------------EYK
CAKCE-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFCALKKNDQEVIISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGNISVSWPAT----K----------ESKD-I
LAPHIGSDKESEQK--------KGQTVFKGA--SRRQQQKYLGKNSKPNELE------SV
YSGDRAFIEKEPLA-HLMTYLEDTSLCQFHKAGGKPASS---PGTPLSK-VD-----FQT
VPENPKRKKYVKTS-KFV----AFDRIINPTKDLYEDKNIRIPE--RFQKVSEQT--QQC
D-----GMRICEQAPQQALPQSF----PKPGTQG--HT-KNLLRPT---KLNLQKSNR--
-------------------------NSLLALGSNKNPRNKDILDKIK--S-KAKETKRND
DK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYDDMRV-------L
GIQEAQMQ-EDRRCTG---YIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE------
------------------------------------------------------------
--------------------

--------------------PK----PGGITQMYSESNEKRNLDASIEMIQSED--SRPV
TFDSGLFAGV-FQS--GIQTTVFNPSPG---EISLNLTFHNNVSIKKLSCRDTETLKTFL
DRIHKKTSHGT-RKPDSDWGVHGRG----TTQEKSN-TS--YLQK----------TCDDP
RHQKMLS----------------------------------------------VTSKSP-
TPDGKRFFENPCNKRERRLSDLE-V-Y-KDL---KDKKSILNK--KFKKDCFKYARSNRK
XXXXX---XXXXXXXXXXXXXXXXXX------------XXXXXXXX------XX-XXXXX
XXXXXXX----------------------XXXX--XXXXXXXXXXXXXXXX---------
-XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-XXXXXXX-XX--XXXXXXXXXXXXXXXXX------------XXXX
XXXXX-XXXXXXXXXXXXXXXX----------------------------------XXX-
------------XXXX-XXXXXXXXXXXX-XXXXSSPSR----N-------E----DT-K
WPLLLDSNPQTEEPQDKVSQDMISGAIISM----------EGLDEERECRIPEGS-QS--
----------------------VQLPR------DRKRIY---EKILQLS-TP------QI
L------TM------------------------------SDTPE---------------Y
S---------------------------------

PF00443 // ENSGT00440000033542_0_Domain_5 (995, 1164)

-KE--ENRSTK-----LHLQEDS---
------------------------------QKSSRVWSNKDNTGIQVT-E-TSDGAKQNA
AGEDLCHAYRLISVISHLCG--KSVH-YVRDIYDFA----KQHWFV-DDLWV-------F
QIKEAGMQ-EDRCRNG---YIFFYMHNRILETLLKRAETSQHTQTEMILY----------
------------------------------------------------------------
--------------------

-------MVPVAAHGFVQLWNK----KNGMSKSK---------EAVVEVSGKKKKTKLVI
CFCNGE-SRT-FELHNNIKNVVVRSYGEKVNHLHLTFQNNSFFFMEKISSKDVKKLKAFL
DGVHQNHLPPP-IKPDVDSSAFAST----TVQKTVD-ET---------------------
SFQKVGKKSDSQSFEKEEKNGTPS---------------------------S--ASESL-
TSTYEQLIEDEYGKRQNMG---R-G-RSPHF-QRGS-SSARKR--KSRRHLLRNVSHNEK
KELRI---KGLKQSK-LDLEFLFK---------------ISPYLHG-----TNL--FPKL
SENIYFTFLSEAE---------------------YGKD----------DPYWDRLKLTLD
YYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAVLQSL-FLIPSF-GDDLLNRTYPWCKIPPDAL-SMC
L-AQLFVLKDIYNINIKKRLLANIKKTISAV-AEIFADNAQN-DAHEFLGHYLSQMKE-N
MEKLNKVWKTKIESKEENSLQPF--FVGSAA-KEALLCPVIT-NFEFELLC-SITCKACG
HAV-LKTEVSNYLP-INLPQGR-QALPF-SIQ-SSLDLFFETENL------------EYT
CEQCK-HKKSHVKYKFSRLPRVLIVHLKRYNFI-EFRSLKKDDQEVIISKNLKISSHCNE
NTRPPFPLNKKAHLIN-LKFLKIFRNLNSEAISKLTPSA----K-------MTSEFMK-S
LPSYIVPDDEPEPE--------KDHVHHEGL--REEEKQKDLGKYSILKILDS----ALA
NSQDGLIVARELLAVALMMNMEDCSFSL----REITISD---PDVC------------QK
VFENPKLKEDERIN-MFA----DFEAVAKITKDKDEN--AKISE--DVSPVAEQT--QNK
E-----RMKTYEQALWLALLQSF----PKPKTQKKKCT-EKLKRPK---ESGVQGTKV--
-------------------------NSPGASGRNKKSRKKSCLGTEKTEA-ASNEPKGEA
EMEDR-QAYRLIGVLSHLGKSLNSGH-YISDAYDFV----RQEWFTYNDLQV-------T
NIEEATMQ-KARLSSG---YVFFYMHNEIFEELLERES-SPPSSTEVGKISQEQEER---
------------------------------------------------------------
--------------------

------IMSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKISLVV
HYNTGGIPRL-FQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDKVPSKDAEEMRLFL
DAVHQNRLHTAM--KPQGSGSFGAVLGSRTSQKETN-RQLSYSDNQVSSKRGNLETKDDT
PFRKVLGNPGRGSNKTTAGSGITI---------------------TR

PF00443 // ENSGT00440000033542_0_Domain_1 (228, 1164)

TIPT----LTSTS
TPLRSGFIENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRSGSKDYSSGSTNLDX-----XXXXXXXXX
XXXXXXXXXXXXXX-------------XXXXXXXXXXX----------XXXXXXXXXXXX
XXX-XX-XXXXX--XXXXXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXXXXXXXXX-X-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPFPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKVGQQVIIPRYLTLSSHCTE
NTKPPFTLGWNAHMAI-SRPLKASQMVNSCVTSPSTPSK----N---------FNIKSKN
LALCLDSDSEDE-LKRSLA---LSQRLCEISGSEQHQ--EDVEKDAKPCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKRETSPSLSHDDDDKPTSS---PDTGFAE-DD-----IQE
MPENPEPMDIDKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQXXXX--
-------------------------XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XTGNLPHSYRLISVVSHIGSTSSSGH-YISDVFD----IKKQAWFTYNDLEV-------S
KIQEASVQ-ADRDRSG---YIFFYMHKEIFDELLETEKNSQTLSMEAGKTSRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKR-ISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPIEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MAPLIVHGFAQIWSG----NIRMSKTK---------EAYIRTVEEKKKVILVV
SFNTGE-YTT-FQL-VNIKNVVFRSYGENENQLNLIFQNDDFLFIEKLSLRDGKELKMFL
ESFRKNNE-LP-MRPDRVGGVFASR----TIQKEIN-KT---------------------
SFHKVCKKSSSGSYETGEGTGIPD---------------------LQKMPLF--TSKLP-
TRTCEELLENRCEKGKRKLSSAS-E-TNEDI-PKQS-NSIGNK--KSKTSLLRYVSHNEK
KKLRL---KESRENKKCGFS--LKSNF-----------TGNPYIDG-----TSL--PRIL
YQKMYLAFLLEPK---------------------YSED----------EPEWQKLKMSFE
IYPEKV-WE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-FSIPSF-ADDLLNQGFPWSKIPLDVL-SMC
L-AQLLVLKDIYNIKIKEKLLMSIKKIISAV-AKIFSGNIQN-DAHEFLGHCLDQMKE-N
IGRINTIWKARSESEEENSPQQV--FASSAA-TEVLVCPVVT-NFEFELLR-SIICKACG
RVV-LRTEVNNYLS-VNLPQGP-KAVPL-SIQ-STFDLFFGVEEL------------EYK
CEKCK-HRRSVAVHKFSRLPRVLIIHLKRYSFN-EFCSLRKDDQEIIISKYLKLSSHCNE
STKPPLPLNKNAHIRD-LQILKIFQKIHSEAISSLTAST----K-------LTLESKS-S
LTPHAGSGKESEPQ--------KYQILNKGT--SREQQQKDLGKYSKLNIIES----KLL
NSGHGTIIEKELLAASLMMGLEDTSFSLTHEGEGKSHSG---PDTRV----H-----PQE
VLEHLKLKKYEKTR-MFV----DFESATETTKDFSEDKKARIPE--GYPKVAKQI--QQC
K-----RMRIYEQALRQALLESL----PEPDAQW--HT-EKLRRPT---EVTLQEANV--
-------------------------SSLGALGSNKNPGNKDVLDKEKTET-KAKKPKRNA
EIRDR-HAYQLIGVVSHLGQTPNSGH-YISDAYDFE----RQVWFTYNDLLV-------S
SIQEALMQ-EARLCTG---YIFFYMHNEIFEELVGREEKFQSSNANAGETPQGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSSLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-VKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGANLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRYNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPISGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPIEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-----------------------------

PF16674 // ENSGT00440000033542_0_Domain_0 (30, 125)

MSKTK---------SVCIESTVGKREVKLLL
YFSTGK-IKA-LQLNNNIKSVILRTYGDNQNYLHLTFKNNDFLFVEKLNTTDARQLKRFL
DKVY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QKNLRAS-KRNDEETSGGPST----STE-ELG-GS---------------------
SSLEVHSEAGSKCLESAKES---------------------------EVPLP--SSSPA-
TLSSMELFGKQLIKRKRSL-PDS-E-K--KGKE-NI-PKDSSR--ECEAKSVVPVHDDKG
KERDL---GEAE-MSKPGFGFSFETNY-----------SEESDSDI------HN--LHDL
IRKFFSPFLLEPH---------------------CVQK----------GVEWHECMKTLL
LYPEKA-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSVPLF-VNDLFNQGFPWIKPPTDDF-NMR
L-MQLLVLKDIYNTKTRENLLISITKALPEL-ADAFIADTQN-DAHEFLSLCLVQLKE-T
VQKLTVLWQSESESGGNSLLRRI--FAGHAIVNKIPVCPVAN-NFEFELLR-SIFCKGCG
LAV-FNKEQSSYLS-INIPQGL-KGQNL-SIQ-SSFDLFFKAEEL------------EHR
CERCM-HNRSIALHKFGSLPRVIILHLKRYSFK--SQVMKKDEQHIIISKYLKLSFHCNR
NTKLPQPLSQNAHVKD-LDLLKPLQELGSEILEFSFNSL------------RASRFKD-F
TTGDTRSDNESEAQ--------NVKIVSKVL--SGKGQQEDQRYGDTANVIGS----ELT
N-----------------------------------------------------------
--ETGNLKKHKKVD-LLR--KLDSGRISEATEE----SDIRIPE--RSPKY-QQA--QKC
S-----EERRDKQTSGEAVAQKH----PKPRSRE--QI-ESTRKPA---EAHTQNGKL--
-------------------------KSQGSLDSSRNPGNKDGLGKK-RKSKVK------V
SDKEE-NAYRLFNIISHIGSSPQGGH-YINDAFDFR----KQDWFTYSDPQV-------T
STQEDLVC-KARLSTG---YVFFYMHNEIFEELLARETRSRKMSQK--------------
------------------------------------------------------------
--------------------

-------MAPLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNVGGIPKT-FQLSHNIKTVVLRPNGGKLCCLMLTLKDASFLTIDKVPSKDANEMRMYL
DAVLQDRVHTT-VKPSQGSGSFGGVLGSRTTQKEANTRQFQYIENQVPSKRVTVEGKEDN
PFRKVLGSPSRASVKTSPGSGTSS---------------------NRVNISVSP---TSS
TPHRTGLLENRE-KRKRTQPSSS-E-MNEDY-PKENDSSTNNK--AVTDPAWKFLNSSRE
KQLNL---KQSEEIRTSGVLPLQSSSFYGSRSTSKDYSTGNSNLDR------SSISSQTP
SAKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
SHPQ-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVCSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVSGEDNSP--GRASDDISA-TKIYTCPVIS-NLEFEVQH-SIICKMCG
ETV-TKREQFNDLS-IDLPRRK-KLLPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRPPLTLGWSAHSAV-SRPLKASQMVNSCTVSTSTPCR----K-------YTFKSKS-S
VALYVDSDSEDEPLKRSVA---HSQRLCDVQSREQQQQQEEPEKGSKRGKPECDKSSDLG
NAGFDGMSEDELLAAVLEISKRESSFSVSH-DEDKPTSS---PDTGFGE-DE-----MQE
LPENLQSTEMEKSK-PTT--ESGPANFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGTEDVLDMEYSEA-EAEELKRNA
EVGELPHSYRLISIVSHIGSTSSSGH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLEASVQ-CDRDRSG---YIFFYMHKEIFDELLETEKNTQPLSMEVGRSVRQPL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MAAQTIKGFVQIWNP----KTGMSKSK---------AAFIGTMEGQKKVRLVL
YFKNGK-YMT-FLLTDNIQNVVFRSYRGNQNHLHLTFKNNKFLFVKGLSSTDAEMLRILL
DRFHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

KKVWPP-VKPDKGGSVFSST----TPRKKIN-KT---------------------
SFRKVGEKSSHKSFEKAKGS-GTG--------------------VLQRMPLL--KSESS-
ALTCGKLLEKQNKKRKITLLSSS-E-MNEEF-LEEN-NSVECK--KSKLDCFRCVSYKQE
KQLKL---KELEEKKKLECESSCIVNS-----------TVNPYLDD-----ICL--LQAL
TEKVILAFVLQPG---------------------YSED----------YSKWDKLKLFFE
LFPERL-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-FSIPSF-ANDILNRGFPWSKSPLNAL-TMS
L-ARLLFFKDIYNIEVKEMLLLNIKKVMSAV-AEVFHGNAQK-DAHEFLGHCLDQLKDDN
TEKHDTIWKPKSEVSEYHFPKQV--FADDPD-TNGFSCPVTT-NFESELLH-SIVCKACG
QVI-LKTELSNYLS-INLPQGR-KAFPS-PIQ-STFDLYFAAEEL------------EYK
CAKLLCTRLSVGMHSFSRLPRVLIVHLKRYSLN-EFCSLKKNDQEVIISKYLTVSSHCNE
DTKPPLPLSEDADIMD-FQELKVIRKMTAGSISVSWPST----K----------KSKD-T
LAAYIGSDKKSEQQ--------KFQTVFKGA--SRRQQRKLLGKK-------------FV
YSGDRAFTGNKPLA-YLMAYLEDVSLSQCHKAGDKPASS---PDTCFPE-ALFPEAPFQA
VPENPKQKKYAKMS-MFA----GFGRVFNPTKDFCEDKNISVPE--GFQKVTEQT--QNY
D-----SKRICGQVPQQALPQSL----PKPGAQG--HT-EKLIRST---KLNLQKPNR--
-------------------------NSLHALGSNKNPRNKDILDQVK--S-KAKETEINA
NK-GD-HTYRLISVVSHLGKTLNSGH-YICDAYDFE----KQTWLTYNDMKV-------L
SIQEAQMQ-KDRRSTG---YIFFYMHNEIFEEMLKREQNAQLHGKEIEEILWKK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPRKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKSSQGSGSFGAILGSRASQQETN-RQLSYSDNQTPSKRGSLEMKDDT
PFRKVLGTPSRGSIKTVAGSGMAV---------------------TRTSPS----LTATS
TPLRSGLLENRPEKRKRMLSPGT-E-LSEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGPLPLQSSSFYSSRAGPKDYSSGGTNLDR-----YDNISSQTP
SAKRSLGFLPQPSP-------------LSVKKLQCNQD----------YTGWNKPRVPFI
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFALLLVKKDVCNSETKKDLLKKVKNAISST-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKIEPFLGEEHSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRR-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCAVVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRFLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-P
LTLCLDSDSEDE-LKRTIA---LGQRFGEMLGIEQQQ--EDVEKDSKSYRMEPGK-SGLE
NSGFDRMNEEELLAAVLEISKSEGSPMHSHEEDDKPTSS---PDTGFAE-DD-----IQD
MLEHPDAVQTGKPK-TVT--EPDPSSFAEITKDCDENKENKTPE--GSQGEVDWL--QQC
DM----EHEREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQGMEI--
-------------------------IF------------------NYIFF-KMEFLGQKI
KTGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEADVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTRPAS-----
------------------------------------------------------------
--------------------

-------MSAPKIRGVIQAQGH----RKGMGNLG---------GAYIEMVEGEKENRLVM
VFDSSSFVGV-FELRDI-TRSVFQDSREGPICLNLVFQKNFSMTIKELSCRDAEELKLFL
GVGQNRAKQ---------------------------------------------------
---------------------------------------------PKETPSI--TATSP-
--RPVRKFTDPNDKMETVLTPDID--HGQGI-LKEN-TSAHFK--TFANKDLKDMKS-EK
TQFLL---EHAGNTMKPNHGQSFSTTS-----------QGNSCLEN-----NVF-ATGNL
SAERSSAVPSDPN--------------------RDYHK----------EPRWNESQLPLQ
MHPK

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

PF-VPGFP--NLGNTCYMNATLQSL-FAVPSF-AEDLTHQGIPWEMLPAGAF-SLG
L-SQLLVFKDVCDAQTKTEFLVAIQKSISLV-SDIYSSNTQN-DAQEFLGHCLGQLKE-D
MEKLQSTGQGVRETADGHPEPQV--LAAQAA-PRGLACPVRA-NFEVELQH-AIVCKACG
AVV-CKTELSNYLS-ISLSQEQ--PGAW-SLQ-DSLDF-FRAEEL------------EYK
CGKCK-HGRSFVIQNVSRLPRVLIVHLKRYMLS-ASERLVKDTQPVGIPKYLSLSPHCNE
DTKGPLLLDSPAHAEE-HPNLNVSQDIISGATSSRESER----S----------------
----------QE-----------------MV--IPR------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------V-DAKELSGSQ
EVGQPRHAYRLISAVSHLGSSTESGH-YVSDLYDFA----KQAWFTYDDLRV-------S
QTQEDWVR-ADRRRDG---YIFFYMHNDIFELLLRDAQNSQ-------------------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPIEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SLVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKSSQGSGSFGAVLGSRPSQKETN-RQLSYSDNQVSSKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--VMTDPSRKYLTNSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSSVANLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDNCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPTPGEESSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKKEQFNDLS-IDLPRKK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTTI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCIDSDSEDE-LKRSVA---VSQRLCEMSVSEQQQ--EDLEKDSKLCRLEPDK-SELE
NSGFDRMSEEELLAAVLEISKREASPTFCHEDDDKPTSS---PDTGFAE-DD-----IQE
MSENLDTVEAEKPR-TVL--EPDPASFAEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNS--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQETAVQ-ADRDRSG---YIFFYMHKEIFDELLETEKNSQALNMEAGKTARPTS-----
------------------------------------------------------------
--------------------

-------MDAVMVHGFVQMWEK----NSGMSKSK---------EAFIETVPGRKKDKLVI
YFNAEK-MRT-FQLTDNIKSVVLRSREDDQNHLHLTFQNNNFLFIERLSSSDAQELKLYL
DRVHQKKLEPS-MRAHKDKPISISK----ATQQEIS-ES---------------------
STCNIAKNSKSGSRETAKGSVSPV---------------------HQKIP------KKS-
VLNCKKLLEDQHGKRKRMLSD-S-E-INENK-SLTK-DPTRKK--KSDRNILKCISHSLK
----------LKENKKLVLNSSFMTES-----------SENPCLKG-----SEI--LQTL
TEEMFLAFMLKQK---------------------YSEY----------FPEWDKLGISFD
FHPEKI-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNAVLQTL-FSIPSF-ADDLLNQRFPWGGIPVDGL-STC
L-AQLLILKGIYNVKVKEKLLVNVKNAISAV-AEIFSGDTQN-DAHEFLGHCLQQVKE-N
VVNLNTMWMNKNESEEENSSQDE--FASSSA-SKMPACPVIT-NFELELLC-SIICKGCG
QFV-IKMEPSNYLS-INLPQGK-KMFPV-SIQ-STLNNFFSAEEL------------EYK
CGKCQ-HKRSVAFHKFNRLPRVLIIHLKRYSFN-DYWSIRKDDQEVIISKYLKLSAHCNL
NTKPPFPLSKNTHPRE-LQILKIFQTVNSGIISSP-PSK----N-------SASDLKK-S
LDLPVAS--YDESN--------KFQRIFKGS--KKGKKQNDLGKDSKLNTVEA----EFV
NPGDKTLREKQPLA-GSVRHLGDTSLSLNRKGRGKHTTN---PYTRLEA-L------LQK
LTENRKLQVYGKTS-VPV--ELDSDGVTK-TKDSYENKKHTIQE--GSPKVANHI--QKC
A-----GVRIYKQASQQVPPQSL----PKSKAQK--QA-ENLTRST---EFSFQAVSA--
-------------------------NHVSALGSNTNPGNKGIFGEKKMDS-KAQEPKINT
DK-AN-HTYRLIGVVSHLGSSPDSGH-YISDAYDFE----RQAWFTYNDLHV-------Q
SIQEAPML-NSRACTG---YVFFYMHNDIFEELLKREKNSQLPCTGARKTPQKK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKP-QGSGSFGAILGSRTSQKETN-RQLSYSDNQTPSKRGSLETKDDI
PFRKVLGNPGRGSIKTAAGSGIAV---------------------TRTIPS----LTSTS
TPLRSGSLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGSTNLD------RTNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YAGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEETSS-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVFIPRYLTLSSHCTE
STKPPFTLGWSAHTAI-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKC-S
LALCLDSDSEDE-LKRSVA---LSQRLCEVSGCEQQQ--EDLEKDSKSCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENQDPVETEKPK-TLA--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQAVSMEVGKTARQAL-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DEVHQNRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAI---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSVGTNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SH

PF00443 // ENSGT00440000033542_0_Domain_1 (423, 1164)

QQQQ-LQ---------------------------------------------------
-------------------------------------------DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DTSA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDSKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKKFELGTRGTGKTTRQAL-----
------------------------------------------------------------
--------------------

-------VSPAPSPWWV-PIKQ----RPGNIILE---------DAFAETVERGEAQPV-V
LFCW-GLVRV-FQVSET-ASSVFRSYGKRQNCLYWPHENNS-LFFRTFSFRSSERLAILL
DTIRQKELEDS-SKSRSCWTVMEGQ----NADTDTD-MT---------------------
LWEDLCSILMCENFNP------------------------------QQESSS--VPKSP-
QLAKQGSPQNTNRKRQRALSS-----MGQDF-LKGN-NTVPNK--KVKQC----------
---SP---RAPEEDAHSKLAPPPGTTS-----------DGNSNQDE-----TVV-SAWSF
SDKSS-VLPSEAE---------------------LSHD----------DGNH-----TRD
CDSE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QV-LKGFP--NLGNTCYMNSILQSL-LAIPSF-VHDILQQGIPWENIPRGEL-LMS
F-FKLLSLKDSCTVEMKADILAGMKGVISAV-AGTFSGNQQN-DAHEFLGQCLEQLKE-D
IAKLNTIRKAEREPGGGNSPAQL--LSGSAT-TKVFHCPVVA-NFEFELQD-HMLCQACG
EVS-VKTEPGNCVS-VHMPPDRKQSSPQ-SLQ-NCLELVFQGEVR------------EHT
CAKCA-HSTSMVTHTFGRLPRVLIIHLQRYCFS-ESYVLEKDDRQVQIPRYLSVASQCNE
STQQPLPLARTAPGCG-CQVLSGKG--ISATGRPPTRSE----G-------FSAGCGD-S
SDPRSELDR-DVPH--------KPQRVCAD---GQGRQQRDPGKVS---ELES----DLR
SCGDGHVRETELQEADP--------------------------DAGL-M-AH-----HQE
VPGYPQREDCETKS-AGA--EVGV---------SCESETHKVPG--GQQMLNQLL-----
------------------------------------------------------------
--------------------------------QYGESGTKHVPEVEETAA-EAERLAADV
STGDRLWSYRLVSVTSHIGGSPYSGH-YISDAYDFR----KQSWFTYSDQHV-------R
ETSETMVR-KARLRSG---YIFFYMYNEMFEELVRKAASTQPTSSGE-------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MAALVAHGFVQIWSR----KTGMSKSK---------EAFIQTVERKSKVRLVV
YFRTGE-HTT-FRLSNNIKSVVLRSYGKKQNHVHLTFQDNSFLFIEKLSSRDAENLKAFL
DRVHE

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NNLQPP-IRPDRDGSVFAST----AVRKPVN-KT---------------------
SFHKTCKKSGSPSFEKGGKNETPD---------------------LEKMPLF--ASKSS-
TLTWEELLENGYGKRKKMLSSGS-E-MNRNF-LKEN-IFVRKK--RSKTNPFRHASHKER
KESR------LKQNKKLEFGPSFKISS-----------TGKPYLDG-----VGL--LQML
TKNIYLAFLSESK---------------------YGED----------DPDWDKLKMTLD
FYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAVLQSL-FSIPSF-ADDLLSQGFPWGKIPLDAL-NMC
L-AQLLVLKDIYNIKIKERLLVNIKKAISAV-AEIFSDNIQN-DAHEFLGQCLDQMKE-N
MGQLNSIWETTFESEQGDSPQQV--LTGSTA-TEMLVCPVIT-NFEFELLC-SIVCKACG
QVV-LKTEVSNYLS-INLPQGT-EALPL-SIQ-SSFDHFFGAEEL------------EYQ
CEKCK-HRGSVAVHKFGRLPRVLIVHLKRYSFN-EFWSLKKDDQEVIISKYLKLSSHCSE
STKPPLPLSKNAHIRE-FQILKIFQRINSEIFGLSTPSA----E-------PTSESKD-S
LAAHIGSEKEAESQ--------KYQILDKGL--SGEQQK-DLGK-STPNVMDS----TLL
NSGDGAAIARELLAVSLMMDLEDNFLS----PKGKPTSS-----TC------------QE
VPENPKLKKCKRSN-MFV----DLEGVTETIKHVCK-DKPSRIS-EVFHQESEQA--QQY
E-----RLRLYEQALWLALLQSL----PKPG-AR--YT-KNPRRPT---EVHFQGADV--
-------------------------NSLGALGSDKNPGNKKCLDRK-TEP-ETKKPKRNA
EMEDP-HAYRLIGVVSHLGKTPNSGH-YISDAYDFE----RQVWFTYNDLQV-------S
SIQEAPMQ-EARLCTG---YIFFYMHNEIFEELLEREENSQPHSTEAGKTPRE-------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MDPIVIHAQVQMWSA----KAGMSKSK---------SVCIESKVGKQEVKLLL
YFSSGK-IKA-LQLKNNIKSVILRTYGDDQNYLHLTFRNNDFLFVEKLTTTDARQLKRFL
DKVY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QKNLGAS-RRSDEETSGGPST----STE-ELG-GS---------------------
SSMEVHSGASSKCLESLKGSETSV---------------------LCEVPLP--SSSSA-
SLNRLGLLEKQLVKRKRSS-PDS-E-M--KEKG-NV-LKYSSG--KFEVKSAVPVHDDKG
KERDL---REAE-KSKPAFGFSSETGY-----------HEESDLDV------RN--LHDL
IRKLFSPFLLEPH---------------------CMEK----------CVEWHEYMKTLL
LYPEKA-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSVPLF-VNDLFNQGFPWIKPPRDDF-NMR
L-MQLLVLKDIYNTKTREKLLISITKALPEL-GEVFTADTQN-DAHEFLSLCLVQLKE-T
VQKLTVLWQSENESGGNSLVRRM--FADHAIINKTPVCPVAN-NFEFELTR-SIFCKGCG
LAV-FKKEQSSYLS-INIPQGM-KGQNL-SIQ-SSFDCFFKAEEL------------EHR
CERCM-HNRSIALHRFGSLPRVIILHLKRYSFS-ESQVMMKDEQHIIISKYLKLSFYCNK
NTKLPQPLSQNAHVKD-LDLLKPLQELGSEILKFSFSPT------------RTSGFKD-F
PSVNTGSDKESEAQ--------NVNRVSKVV--SGNLQQEDQGKGDTSNVIGS----ELT
N-----------------------------------------------------------
--EAEKLKEHKKAD-LLS--NLGSGTISEATKD----NGIRIPE--RSQKY-QLA--QKC
S-----EERKSHTS------------------------------------------DV--
-------------------------SSQDSQDSCKNPGSKDDLCKK-RKPKSKVDA-QGV
TDKEE-NSYRIFNIISHIGSSPHGGH-YINDAFDFR----KQDWFTYSDPQV-------T
SIQEDLVC-QARLSTG---YVFFYMHNEIFEELLARETRSRKVSQK--------------
------------------------------------------------------------
--------------------

-------MDPVAAHGFVQLWNK----KNGTSKSK---------EAIVELSGKKKKTKLVI
HFCNGE-SRT-FELHNNIKNVIVRSYGEKVNHLHLTFQNNSFFFMEKISSKDVKTLKAFL
DGVCQNHLPPS-IRPDVDSSASAST----TVQKIVD-ET---------------------
SFQKVGKKSNSQSSEKEEKNGTPS---------------------------S--ASESL-
TSTYEQLLEDEYGKRNK-------K-LSWDF-QNES-SSVKKR--KSKRHLLRIVSHSEK
KELRI---KGLKQSK-LDLDFLFK---------------ISPYLHG-----TNL--VPKL
SENIYFTFLSEAE---------------------YDKD----------DPYWDRLKLTLD
YYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAVLQSL-FLIPSF-GDDLLNRSYPWCKIPPDAL-SMC
L-AQMFVLKDIYNINIKKRLLVNIKKTISAV-AEIFANNRQN-DAHEFLGHYLSQMKE-N
MEKLNTLGKTKIESKEERSPQPF--FAGSAA-KQALLCPVIT-NFEFELLC-SITCKGCG
HTV-LKTEVNNYLS-INPPQGQ-QALPF-SIQ-SSLDLFFGTENL------------EYT
CEQCK-HKKSHIKYTFSRLPRVLIVHLKRYNFI-QFRSLKKDDQEVIISKNLKISSYCNE
NTRPPFPLNKKAHLMN-LKVLKIFRNINSEAISKLTPSA----K-------MALEFMN-S
LPSHIVPDEEPEPQ--------KDHVHHEDS--REEEKQKDLGKCSVLEILDS----ALA
NSQDGIIVARELLAVALMMNMEDGSFSL----REITVSD---PDVC------------QR
VFENPKLKDDERMS-MFA----DFDAVAKTTEDKDEN--AKISE---VSSVAEQT--PDK
E-----RMKTYEQALWLALLQSI----PKTKTQKKKCT-EKLKRPK---ESGVRGTKV--
-------------------------KSPGASGRNKKPGKKGSLRTEKTEA-ASNEPKGEA
EMEDR-QAYRLIGVLSHLGKSLNSGH-YICDAYDFV----RQEWFTYNDLQV-------S
NIEEATMQ-KARLSSG---YVFFYMHNEIFEELLERES-SPPSSTEAGKTSQEQE-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MDPVLIHAQVQMWSA----KAGMSKSR---------TAFIETVVGKREVKLLL
YFVTGR-IKS-LQLKNNIKSVVLKTYDEDQNYLHLTFKNNDFLFVEKLTSTDARQLKRFL
DRV

ENSGT00440000033542_0_Linker_0_1 (124, 429)

YERNRRTS-RRSNEERADGPST----STH-SL-------------------------
-PLKVRSEASRKCFQLGEESGAPG---------------------LCELPLF--SSSLT-
TFNNGGLLENPLVKRKRSS-PDS-E-KNRKGKG-NI-LEESNK--EIEATPVVSVHDDRG
KGKDL---REAG-QSQLGLGFSSEADY-----------FEEPDLDV------CD--LYDL
IKKLFSPFLLRSR---------------------CREK----------GIEWHEHMKTLL
LYPEKA-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSVPLF-VNDLFNQGFPWIKPPRDDF-NMP
L-MQLLVLKDIYSMKTREKLLIKITRALPQF-GEVFTADRQS-DAHEFLSLCLVQLKE-T
VQKLTILWQSENESGGNNLLTQI--FADHAITNKIPICPVAN-NFEFELLR-SLFCKGCG
LAV-IRKEPSSYLS-INIPQGL-KGNNL-SIQ-SSFDLFFKAEEL------------EHR
CERCI-HNKSIALHKFSRLPRVIIIHLKRYSFN-ESWVMKKDEQNIIIPKFLKLSCHCNK
NTKPPPPLSENEHVKD-LDLLKPLHDLGSEIFKSSFISM------------TTSQFMD-F
PTASVRSTKESETQ--------NVKRDSKVL--SGKVQQEDQGKGATANVTRS----ELT
N-----------------------------------------------------------
--ETEKLKNREKAR-KFS--KLDSGSISKGTKD----NALKITE--RPPKY-KQT--FRE
A------------------VTQS----HKPRSLE--QR-ENLRKPA---ESYTQNGSL--
-------------------------NSQGSLGSSKRSGNKDGLDKK-TKPTGKVDP-QKP
IGNEV-NGYRLINIISHIGSSLHGGH-YINDTFDFR----KRVWFTYSDAQV-------T
STQEDFVL-KARLSTG---YVFFYMQNEIFEELLSRETQSRNTSQ---------------
------------------------------------------------------------
--------------------

-------MATLMVHGFVQIWSK----KKGMSSSR---------EAYIETVEGKKKIRLVV
YFTNGE-YLT-FQLSNNIKNVVLRSYGKKQNHLHLTFQNNNFLFIERLSSKDAKELKMFL
DKVHQNNTQPS-MRPVKDGGIFASM----TTPKEIN-KN---------------------
SFHRACKKPGSGSFETREGSGTPD---------------------LQKMPLF--TSKSS-
RLSWKDLPESGDGKKKKMLSSGS-E-MSGKI---QS-NSVRKK--KSQTNPLRYVSHDEK
KKLRL---KLLKKNQKLEFEPLLKSIS-----------PGEPYLDG-----KSL--LQML
SEKIYLTFLLEPR---------------------YNAD----------DPEWDKLKMTFN
FYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNAVLQSL-FSIPSF-ADDLFSQDFPWGKIPLDAL-RMC
L-AQLFVLKNIYNIKIKERLLVNIKKAISTV-AEIFSGNIQN-DAHEFLGHFLDQMKE-N
MGKINTLWKMKIESEQDNSAQQV--FAGSAT-TRVLICPIIT-NFEFELLR-SIICQACG
QVI-LKTEVSNYLS-INLPRGM-KALPL-SIQ-SAFDLFFGAEEL------------EYR
CEKCQ-HRSSVAVHKFSRLPRVLIVHLKRYIFN-EFWSLRKDDQEVVISKYLKLSSHCNE
STKPPFPVSKNAHNRD-FQILKLFQKMSAGTICPSAASS----K-------LASASSD-S
PVPHAGPDKGSEPQ--------KCQIFYDGS--SRVQQKKDLGKSSEQNITES----KLL
NLGNGALIEKELFAAGLMMDLEAVSPSLIHDKDGKPTSS---PEIRLAE-AY-----LQE
ASENLKQKKYDKTD-MFV----DFESVAKILEDFFEGKKPRISKKTEFQKAAERR--QQH
E-----AMRIYEQALQQALLQIL----LKPDAQW--YM-QNLRRPT---NLGPQQARV--
-------------------------NSQGASCSTKNPGNKKVLDTEKTEI-KAKKSKRNA
KVNDR-YAYRLIGVVSHLGKTPNSGH-YISDAYDFE----RQVWFTYNDLQV-------S
SIQEALMQ-EARLCTG---YIFFYMHNEIFEELLKREENSQSPSTETGEIPQEK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPVEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

--------------------------------MA---------ALL

PF16674 // ENSGT00440000033542_0_Domain_0 (47, 126)

LHAVEGRKKDRLVL
YFKNGK-YNT-FQLSDNIQNVVLRSCRGNQNHLHLTLQNNNVLFIERLSSTDAEQLKTFL
DRVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKVQSP-VRPGKGRSVFSST----TTQKEIN-KT---------------------
SFHKVDEKSSRKSFEIAKGSGGTG--------------------VLQRMPLL--TSKSS-
TLTCGELPENQHKKRKRMLSSSS-E-MNEEF-LKES-NSVEYK--KSKADHLRCVSYNRK
KQLKL---KELEENKKLECESSCIMNT-----------TGNPYLDD-----TGL--LQAL
PEEMVLAFLLQPG---------------------NSDG----------YTKWDKFKLFSE
LFPEKI-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAVLQSL-LLIPSF-ADDLLNQSFPWGEIPPNAL-IMC
L-ARLLFLKDTYNIEIKEMLLLNIKKAISAV-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFGEDNFPKRF--FADDPD-TNGFSCPVIT-NFELELLH-SIACKACG
QVI-VKTELNSYLS-INLPQGM-KACPS-SIQ-STFNLFFGAEEL------------EYK
CAKCK-HKTSFGVHSFSRLPRILIVHLKRYSLN-EFCSLKKNDQEVVISKYLEVSSHCNE
GTRPPLPLSEDGEITD-FQLLKAIQKMISGSISVSWPST----K----------EAKD-I
LASHIGSDTESEQK--------KGQTVFKGA--SRRQKQKYLGKNSKPNEPE------SV
YSGDRAFIEKEPLA-HLMAYLEDTSLCQLHKAGGKPAS--------LAE-VH-----FQT
VPENPKRKKYVKTS-KFV----AFDSIINRTKDLYEDKNVRIPE--RFQKVSEQT--QQR
D-----AMRICEQAPQQALPRSF----PKPGAQG--HT-KNLIKPT---ELNLQKPNR--
-------------------------NSLPALGSNKNPRNKDILDKMK--S-KAKETKRND
NK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYNDMQV-------L
GIQEAQMQ-EDGRCTG---YIFFYMHNEIFEEMLKREENGQLENKEVEETLQEGIRGTYS
-----SLNRSA-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 134)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLIV
HYNTGGIPRI-FQ-----------------------------------------------
------------M

ENSGT00440000033542_0_Linker_0_1 (134, 429)

KPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDM
PLRKVLGNPGRGSIKTVAGSGIAV---------------------TRTVPS----LTATS
TPLRSGLLENRTEKRKRML-SGS-E-LSEDY-PKENDSSSNNK--AVTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSIKKLRCNQD----------YTGWNKPRTPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPFPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKG-S
LALCLDSDSEDE-LKRSVA---LSHRLCDVSGNEQQQ--EVLEKGSKLCQIEPDK-SELE
NSGFDRISEEELLAAVLEISKTETSPSLSHEDDEKPTSS---PDTGFAE-DD-----VQE
MPENPDTMESEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--VSQGEVDWL--QQY
DM----DREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNS--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQESAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSIEAGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLDTKDDN
PFRKVLGNPGRGSIKTAVGSGIPV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMISSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGSTNLDS-----RTNVSGQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHP-QQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTDPIPGE-DSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKKEQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAS-SRPLKASQMVNSCLTNPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGSEQQQ--EDLEKDSKLCRMEPDK-SELE
NSGYDGMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPESVETEKPK-SIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDIKRAT---ELSLQEFNN--
-------------------------AFLDALGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQTWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKSSQALSMEVGKTTRQTL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1112)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPVEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQVFCF--
-------------------------YSNEDLK---------------------VIPTSVF
QTGSLPHSYRLISVVSHIGSTSSSGE-YICSLLH----CSLPSFVRYVFLFSFLFFFFFF
EIQSHS---VTQDGLI---FAFLVEMGEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MALHSLHGPIRIHCL----KVGTSKWK---------EGCCEVIEKDNKYCLVV
NYNAGGMPTR-FQLNQNIKTIVVKPNGGTQSRFMLTLKDASSLTIDKVPLKDAENLKHFL
ESLDKATIVLL-VKSNQGSGSFSGVLGNRSTQIEANRPL--LNKTQTPSKRVSFDGKDET
PVKKLLSNTGRAPVKSSPGNTVSS---------------------GRSGINVT-----PS
PPQRTSMMESRSEKRKRIQTPSP-E-IVEDY-PKENDSSTTNK--ALSDTGRRFLNSSRE
KQLSL---KQTEENRQAGLMPLQSSSFYSSRLTPKEFTTSNTYPDR------SSASSQPP
PAKRSLVLPSQPSP-------------LSVKKLKPNQD----------YPGWNKQRVLST
HPQP

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQPF-AHDLLKQGIPYRKIPTNAL-I-R
RFAHLLAKKDICSPEVKKDLLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MGKLNKTWKTELSSGDDV-P--GVKANDDLS-TRIYTCPVTC-NFEFEVQH-SIICKICG
ETV-NKREQFNDLS-IDLPRRK-KPSPSRSIQ-DSLDLFFRLEDL------------EYA
CEKCS-GKSATVMHKFSRLPRILILHLKRYSFNVILSLNNKVGQQVVIPRYLTLSSHCTE
STRTPLSLGWNAQTALNARPLKLSQMVNSCTMSTSTPLR----K-------QMFKAAN-S
LPVCLDSESDDEQIKRCVS---HSQRICDMELKEQQC--EDKDKNSLLAKKEASKCLETG
DACFDEMNDDELVAAVLEMSKKETSLSESHDDEDKLSSS---PDTGFGGDDD-----VQE
IAENHEPMEEERVK-TSILTNLGVLQYSDMAKDFDENKENKTPE--ASQNDVDWL---QY
DL----EREREEQELQQALAQSL----QEQ-EAREMKEDDDLKRAT---ELSLQEFNN--
-------------------------TLMDGMVSDEDSGNEEVLDMEYSEA-ETEELKKNA
ETGDLPHSYRLISVVSHIGSSSSSGH-YISDVYDVR----KQAWFTYNDLEV-------S
RTQETTVQ-SDRDRSG---YIFFYMHKDVFDELVEEAKKSQPASTELNRPIRPPL-----
------------------------------------------------------------
--------------------

-------MALLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVNLVV
HYNVGGIPTT-FQLSHNIKTVTLRPNGRKLCCLMLTLKDTSFLTIDKVPFKDANEMRMYL
DAVHQDKVHTA-GKPSQGSGSFGGVLGSRTTQKEAN-RQFSYIENQTPPKRVTVESKEEN
TFRKVLGTPARGSIKNSPGAGTPN---------------------NRVNISASP---ASS
VPHRTGLLENRE-KRKRTQPPGS-E-MSEDY-PKENDSSTNNK--ALSDPAWKYLNSSRE
KQLNL---KQAEENRTSGVLPLQSSSFYGSRSSSKEYSTGSSSLDR------SSVSSQTS
SAKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
THPQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVCSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVPNEDNSA--GRASDDLSA-TKVYTCPVIS-NLEFEVQH-SIICKMCG
ETV-TKREQFNDLS-IDLPRRK-KFLPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRLPLTLGWSVHSAI-SRPLKASQMVNSCTVSTSTPCR----K-------YTFKSKS-S
AALYVDSDSDDEPLKRSVA---HSQRLCNVQSRDQQQLQEEPEKGSKRSKMEGDK-PELG
NAGFDGMSEDELLAAVLEISKREASLSLSQ-DEDKPTSS---PDTGFGD-DE-----IQE
LPENLESMEVEKPK-TVL--DSGPASFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGNEDVLDMEYSEA-EAEELKRNA
ETGELPHSYRLISIVSHIGSTSSSGH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLETTVQ-CDRDRSG---YIFFYMHKDIFDELLEAEKNAQPLSMEVGRSVRQPL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLRIHGFIQIWSK----KTGTTGLK---------EALIETEEGEKDIKLVV
IFKSTESIRV-FQLSNNIRSVVLRHCEERQSHLHLTLQNNIALLIDKLSFHDAEQLKMFL
DLAHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKFQQS-K----------SR----NAKKGTD-KT---------------------
LFYKKCYEP---------RNGMPF---------------------PQKMPLL--KPKSS-
TLVNKAFLENRGEKRKKLLSPYV-E-TNDDC-LKES-DLTLNK--KLKVGSSKHVTSNKK
EPSSL---KDLEKDRNLKLGSSFKPNS-----------NRNPNEET-----TVP-STQTF
SAQTGWAFPSEKE---------------------HSQD----------DPRWNNTQVSFD
HHTEKL-WK

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAILQSL-FAVPSF-ANDLLMQGLPWEKIPSDSL-IMS
L-SMLFALKDICNRETQKELLVNVKNAISAV-AEIFSGNVQN-DAHEFLGQCLDQLKE-D
VKKLNSRLEAVREPGAENSSPRM--YVGNAV-TKVFVCPVVA-NFEFELQL-SITCKACS
HTV-LKTELNNYLS-INLHQEE-KTLPL-SVQ-DSFDLFFKAEEL------------EYH
CEMCK-HNSSVAMHRFSRLPRVLIVHLKRYSFN-DAWLLVKNDQQIYIPKYLHLSSHCNE
RTKSPLPL--SVPVGD-HKALKGSQELSPEIISLLTLLA----K-------PTSESSD-S
LVLHVAPEKNADLQ--------RFQRNREAV--NQEHHQRDLENGS---QPQS----KLV
NSEDKTVSEKELPVADSVVEQGDDWLPAACEDEGKPAGS---PGTHLTG-IR-----LQE
APGNPELKKYEETN-TSV--ELDLDTITESPSGLYEPKGIRIPE--GSQGTAGEL--QQC
T-----ERRTNEESLQQALLPPPGRPSRKPDTQE--HAEEALGRSA---ELRLQKANS--
-------------------------SPLGALASAKSPGNKATLEMENTEA-EAKEPKGNV
KMTGALQAYRLVSVVSHIGNSVASGH-YVSDTYDFQ----QQSWFTCNDLRV-------S
EIPEARIQ-EARLRSG---YIFFYMHL-------KKAENSQLLSTRAGVIPQGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MVTLLAHGFVQIWSL----KTGMSESK---------EALIEMVEGDKIVELGL
FFRIGQ-YKA-FQLNDNIKSVALRSYGENENSLHLTFQNNSLLCIERLSSHDAEQLKIFL
DKVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKLPPL-MRPDKDGDVFANT----ATQKEIN-KT---------------------
SYHEDCGKSSRGSFETPKGSSTTA--------------------ALYKMLLH--TSELS-
THICRELSENRHGKRKRMLLSSS-E-MNENS-QKEK-YFTENM--KYKANALRYISHKWK
KKWKL---KELEENKKLEFGSSFMTKS-----------TGNPYLDG-----TGL--LQTL
IKKILVTFLLESK---------------------YTED----------DKDWEEFMLSFF
VDPGKP-WK

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAVLQSL-FSIPSF-AADLLNQDFPWAEIPFDAV-AMC
L-AQLLVLKDIYNIRIKKKLLVNIKKSISAV-AEIFSDDKQN-DAHEFLGECLDQLKD-N
MKKLNTIWKTKSESGEENSPQQV--FVCDAA-TKRFFCPVIT-NFESELLC-SITCKACG
QVV-FKTEPNNFLS-INLPRGM-EELPL-SIQ-STFDHFFKTEHL------------EYK
CEMCK-HKYSFTVSKFSRLPRVLIVHLKRYMFN-EFWSLRKDDQEVIISKYLNVSSHCNE
STKPPLPLSINAQTRD-FQLLKHIQEIISETISSSIPST----K-------------D-S
LGLHIGLNRESEKQ--------KCQKVFKGA--SREQQQKYLEINSKLNK---------I
EPGDGALTEKELSA-PSVTYLEDTSLSLIHKDGGKPTSKMPESDTCLSE-VH-----LQE
MPESPRIEKYVKSN-IFV----DFDTVTEHTEDFPKDKNCRIPE--VFQKGAEQT--QQC
D-----GMRIYEQAPHQAPSQSF----PKPDAQG--HT-ENFRRST---KLNVQEANR--
-------------------------NPLCSLGSSKNPGNKDILDKMK--S-KTKKPKGNV
EKEHL-HTYQIIGVVSHLGNTPYSGH-YISDAYNFE----KQTWFTYNDMQV-------S
NIQEEAML-EARLCTG---YIFFYMHNEIFEELLKKEDNSQL------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MALLKIHGFVQIRSKNRSKHTRGSQWK---------EAVIETVERKQKASLVV
SFKLEGRRRV-FPLGGNVAGVVVSYCEAGLHRLHLTLKDDTSLLIDKLSAFDVEQLKAVL
DSV

ENSGT00440000033542_0_Linker_0_1 (124, 430)

HPSESQQL-EEPERNPDVLESG----D------------------------------
LFCRKHQDTFCGSLNITQESETLF---------------------PMNMSLS--MANSAS
GYVEEERTEKQNKKRKTISTSTV-E-LNEVF-LKES-NTESRK--KSKSYNSRNKRNKGE
KLMPI---RDQEMHNNWKLEPLFSTNS-----------CGKLDLDD-----TVF------
---AS-----GSK---------------------FSQE----------IPIQNDIQSPLD
TCAKQLTRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWEKVSCDDL-IKP
L-SQLLVLKDIRDVEIKGQLLINVKKSISTV-ADTFLGDEQN-DAHEFLSQCLDQLKL-N
VEKLNTMSYAG----T-------------AS-TKMFVCPVSA-NFEIELDS-SIVCEACG
EAT-FNTEVSNYLS-VDLHQGT-KEHPL-SIQ-KSLDLFFTPEKI------------ERN
CEKCK-NKNSVLRYTLRRLPRVLILHLKRYHFT-ANRLLVKSQQPVEISKYLDVSSHCNE
NTKPPYPLTSQSPHEA--------FGMMPDILSQSIPAK----R-------VASDFID-F
TVLQVGSTEDAEVQ--------TLHRMYEEL--SEEQWQRGLENGP---KVEP----KAV
KRENRMLSEKALSAPDS----------VMCD----PLSI---HIPGLAE-IG-----LQQ
VSKNSEFKKYEKIN-VYG--KSDHYTATE-----------------------------MM
H-----GSRIHAELLPWASPQSV------RSTEE--DAGARNT-----------------
-----------------------------------------------------EIDSKNA
ALGADPQNYRLVGVVSHFGSSQDSGH-YVSDVYDFQ----RQAWLLYSDVQV-------F
EIPEALIQ-ENRLHTG---YIFFYMRNEIFDWLLKKASECKLLNTSQDEKNT--ELFSTL
LNGFTYLLEES-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MISLKVCGFIQIWSQ----KTGMTKLK---------EALIETVQRQKEIKLVV
TFKSGKFIRI-FQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFL
DIIHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NKSQQP-MKSDDDWSVFESR----NMLKEID-KT---------------------
SFYSICNK--------------PS---------------------YQKMPLF--MSKSP-
THVKKGILENQGGKGQNTLSSDV-Q-TNEDI-LKED-NPVPNK--KYKTDSLKYIQSNRK
NPSSL---EDLEKDRDLKLGPSFNTNC-----------NGNPNLDE-----TVL-ATQTL
NAKNGLTSPLEPE---------------------HSQG----------DPRCNKAQVPLD
SHSQQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAVLQSL-FAIPSF-ADDLLTQGVPWEYIPFEAL-IMT
L-TQLLALKDFCSTKIKRELLGNVKKVISAV-AEIFSGNMQN-DAHEFLGQCLDQLKE-D
MEKLNATLNTGKECGDENSSPQM--HVGSAA-TKVFVCPVVA-NFEFELQL-SLICKACG
HAV-LKVEPNNYLS-INLHQET-KPLPL-SIQ-NSLDLFFKEEEL------------EYN
CQMCK-QKSCVARHTFSRLSRVLIIHLKRYSFN-NAWLLVKNNEQVYIPKSLSLSSYCNE
STKPPLPLSSSAPVGK-CEVLEVSQEMISEINSPLTPSM----K-------LTSESSD-S
LVLPVEPDKNADLQ--------RFQRDCGDA--SQEQHQRDLENGS---ALES----ELV
HFRDRAIGEKELPVADSLMDQGDISLPVMYEDGGKLISS---PDTRLVE-VH-----LQE
VPQHPELQKYEKTN-TFV--EFNFDSVTESTNGFYDCKENRIPE--GSQGMAEQL--QQC
I-----EESIIDEFLQQAPPPGV----RKLDAQE--HTEETLNQST---ELRLQKADL--
-------------------------NHLGALGSD-NPGNKNILDAENTRG-EAKELTRNV
KMGDPLQAYRLISVVSHIGSSPNSGH-YISDVYDFQ----KQAWFTYNDLCV-------S
EISETKMQ-EARLHSG---YIFFYMHNGIFEELLRKAENSRLPSTQAGVIPQGEYEGDSL
Y-RPA-------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAA-MKP-QGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLETKDDI
PFRKVLSNPGRGSIKTAAGSGITA---------------------TRTIPS----LTSTA
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAASKDYSPGNTNLD------RTIISSQTP
SA-KSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENLP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFNLGWSAQMAI-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKS-S
VALCLDSDSEDE-LKRSVA---LSQRLCEISGSEQQQ--EDLEKDSKLCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAD-DD-----IQE
IPENPDPMETEKPK-TVT--EPDPASFTEITKDCDENKENKTPE--VSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
EIGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDSKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKEAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKPSQGSGSFGTILGSRASQKETN-KQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPSRGSVKTVAGSGIAV---------------------SRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGP-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGSNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YAGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPFNTL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPILGEENSP-------DASA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVVIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
FTSCLDSDSEDE-LKRSVA---LGQRLCDVSGNEQQP--EDVEKDSKLCRLEPGK-SELE
SSGFDRMSEEEVLAAVLEISRREASPVLSHEDDDKPTSS---PDTGFAE-DD-----VQE
MPENPDAMETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEATVQ-SDRDRSG---YIFFYMHKEIFDELMETEKNSQAPSMEVGKATRQAS-----
------------------------------------------------------------
--------------------

-------MAAIIVHGFVQVWTK----NGGMSKSE---------EACIEIIEEKEKSKLSL

PF00443 // ENSGT00440000033542_0_Domain_1 (61, 1164)

SFSAGKCNT--FQLNNNIESIVLRSYEEKRHQLYLTFRNKEFLFIERLSFTDAKDLKMFL
DRIHQNKLQSP-GSPEKDEGVFTST----TTQEEIN-KT---------------------
SFHDVLNKSNSTSFETAKGNGIPV---------------------LQKTPLL--TPKST-
TLTCKGLLENQYWKTKRMLSSDS-E-ITKNF-PEES--SISIK--KPKMNNLSYIGHNQK
IPLNL---KELKEIKKLEFMSLLMAGS-----------NGNPYFQD-----VDE-KIH--
-----MACLLERR---------------------NSA--------------AKEFIL-SF
YCPESP-RQAFP--HLXXXXXXXXXXXXX-XXXXXX-XXXXXXXXXXXXXXXXXXX-XXX
X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXXXX--XXXXXX--XXXXXXXXX-XXXXXXXX-XXXXXXXX
XXX-XXXXXXXXXX-XXXXXXXXKEFPL-SIQ-STFDLFFGAEEL------------EYK
CEKCK-HRSSVAVHKFSRLPRVLIVHLKRYSFN-EFWSLRKDDQAVIISKYLKLSSHCNG
NTKPPFPLSKKAHSRD-FQICKIFQNLNSETNSSSIPST----K-------LTSKSKD-S
TALHIGTDKEPVSQ--------HSQRFFKGV--SREQ-QKGQGKDSRLNIIKP----ELL
CSGDGRFIRKELFV-GPILRLEDTYLSAIREAYSKPTSS---PDARFTK-VH-----VRE
MAENPKLKTYNKTN-LFL--GLDFESVTKTIKGFYKDKP-RIQK--EFQNVAEET--RQY
E-----GMRIYKEALQQALLQSF----PKPVAQG--HA-KNIRKPT---EFHFHEADI--
-------------------------S---ILDSRRNPGTKHSLGKK-TES-VAKEQKRDA
DKGDP--TYRLIGVVSHLGNTPNSGH-YVSDAYDFE----RQLWFSYNDLQV-------S
NIQEAGMQ-QARLCTG---YIFFYMHNEIFEELSRRDENSQLHSTEAGKKPQKE------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKISLIV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXX-X-XXXXXXXXXXXXX---------------------XXXXXX---XXXXX-
XXXXXXXXXXXXXXXXXXXXXXX-X-XXXXX-XXXXXXXXNNK--AMADPSRKYLTSSRE
KQLSL---KQSEENRSPGLLPLQSSSFYGSRAGSKDN-----TVAG-----TNL-DXXXX
XXXXXXXXX---------------XXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXX
XXXX

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1182)

XX-XXXFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNALLR--
RFAHLLIKKDICNSETKKDLLKKVKNAISTT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTESVPGEENSPD--------ITATRVYTCPVIN-NLEFEVQH-SIICKACG
EIIPKREQFND-LS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXX----K-------FTFKSKS-S
LPLCLDSDSEDE-LKRXXX---XXXXXXXXX--XXXXXXXXXXXDPKLCRIEPGK-PELE
NTGFDRMNEEELIAAVLEISKREASPSPNHEDDDKPTSS---PDTGFAD-DD-----IQE
MPENPNPVETE-KPKTIT--EPDPASFAEITKDCDENKENKTPE--GSQGDVDWL--QQY
DV----EREREEQELQQALAQSL----QEQE-AWKEKEDDDLKKATEL---SLQXXXXXX
XX-----------------------X----XXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XTGNLPHSYRLISVVSHIGSTSSSXX-XXXXXXXXX----XXXXXXXXXXXX-------X
XXXXXXXX-XXXXXXX---XXXXXXXXEIFDELLETEKNSQAPSMDVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MISLKMRGFIQIWSR----QTGITKLK---------EALIETVQRKKEIKLVV
TFKSGKFIRI-FQLSNNIRSVVLRHCKKRKSHLHLTLKNNVFLSIDKLSYRDAKQLNMFL
DIIHR

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NKFQQP-MKPDDDWSVFESR----NMPKEID-KT---------------------
SFYNICKT--------------PF---------------------PQRVPLF--TSKSP-
TYVKKGLLENQGGKRKDTLSSDL-E-MNEDI-LKD----ISNK--KYKTDSLKYIQSYGN
NPSSL---EDSEKDGNLELEPSFNS-------------NGNPNLDE-----TLL-ATQIL
EAENGLTFPLEPE---------------------HSQD----------DPRCNEAQVPLD
SLSVQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAILQSL-FAIPSF-ADDLLTQDVPWEYIPFEAL-LMT
L-TQLLVLKDFCSTEIKKELLGNVKKVISAV-AEIFSGDMQN-DAHEFLGQCLDQLKE-D
MENLNAILKTGKERGDEDLSSQL--HVGNAA-TKVFVCPVVA-NFEFELQL-SVICKACG
HAV-LKVEPNNYLS-INLHQDT-KSLPM-SIQ-NSLDLFFREEEL------------EYN
CEMCK-HKSCVAMHTLSRLSRVLIIHLKRYSFN-DAWLLVKNNEQVYIPKYLSLSSYCNE
STKQPLPLSSNAPVGK-CEVLEVSQEMISEVTSPLTPSM----K-------PTSASSD-S
LVLPMEPDKNADLQ--------RFQRDCGEA--SQEQHQRVLENGS---ALES----LLV
NFRDRAFGENESPVADSLMDQGDISIPVICENGSKPISS---PDARLLD-GH-----LQE
MPQHPELQKYEKTN-TFV--EFDFDRVTESTDSCYKCKENRIPE--GYPGMSEQYPCIGC
I-----EKSIIEELLQQAPPPGV----RKLDAQE--HTEETLSPPT---EFRLQKADL--
-------------------------NHLGAFGSD-NPGNKDILDTENTRD-EVKELMRNM
KMGDPLQAYRLISVVSHIGNSPNSGH-YISDAYDFQ----KQAWFTYNDLCV-------S
EISETKMQ-EARLHSG---YIFFYMHNGIFEELLRKAENSRLLSTQAEAAPNFLHRGPVH
C-PSDCWRAATYCAPL-TDHQ---------------------------------------
--------------------

-------MAATMVHGFVQLWSR----KSGMSKSK---------EVYIETVEGKKKIKLVL
YFNNGQ-YKI-FRLSNNIKNVVLRSYGEKQNHLHLTFQNNNFLFIDKLSSSDAEQLKLFL
DRVRENKIQPC-KRPHMQKDGVGST----KTEKEAH-QT---------------------
SFYKVLKKSRYLLAESGKGSEKPA---------------------LKKIPLL--MSKSS-
TPIREGLVESLH-KGNQMTPSKS-E-MNENG---KE-NVTKDK--KSKRDTLRYIRHKWE
KQLKLLKFDDLKGNKKLEFGSSAKSGS-----------LGNPDLGT-----TSL--LQTL
TEKTFLAFLMESK---------------------NTVN----------GPEWEKLKTSFD
LYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNSVLQCL-FAIPSF-AEDLLYQHFPWGNIPLDAL-SLS
L-TQLLVLKDIYNTKVKELLLQSIKKAVSSV-ADIFSGNIQN-DAHEFLGHCFDQLKE-S
LGSFCTVWKTRSEFQEENSPEEI--PTDKEA-TKELFCPINS-NFEFELLR-SIVCSACG
HVV-LKAELNNYLS-VNLPQGP-KLSSS-SIQ-SMFDLFFEAEEL------------EYN
CAKCS-HKISIGEHQFCTLPRILIVHLKRYGFN-DVWSLVKDDQEVIVSEHLNVTAYCND
STKPPVPVSKNVQKKD-FGALQVFQKMNPESLSSLTSSL----K-------LTLESKD-S
LAQHLRSDVSGPE------------WVCKRA--SRKQERKELRKVAKLNIMQS----ESS
RLKQKTLIERELLASSELHENQRVGTPVEIEDFDEQTLLCDEITICDEV-LEPPQAPLGS
F-ANLVPQSYTEDSSSST--ELN------SQEDTVMSSEPQQAPPGNFTKLVLQS--HME
DSSSATKLNLQEDIGTSPEPQQA----SLLVPQS--HT-EGCSPPA---ELNLQEDVV--
-------------------------MYQGALDSNQNPGKKGILDKK-TEP-KATEPKRND
DKDDR-YTYRLIGVVSHLGKTPNSGH-YLCDAFDFD----RQVWFTYNDMHV-------S
NIQEDLMQ-KSRAGTG---YMFFYMHNKIFEDLMKRPKTSQVPSKEKGMPPREK------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKSSQGSGSFGAILGSRPSQKETN-RQLSYSDNQVSSKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGITV---------------------TRTIPS----LTAT-
TPLRSGLLENRTEKRKRMLSPGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTNSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSSVTNLDR------TNVSSQTS
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTESTPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTTV-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LAFCVDSDSEDE-LKRSVA---VSQRLCEMSGGEQQQ--EDLEKDSKLGRIEPDK-SELE
NSGFDRMSEEELLAAVLEISKREASPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MSENPDTVEAEKPR-TVT--EPDPANFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EVWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQETAVQ-TDRDRSG---YIFFYMHKEIFDELLETEKNSQALSTEAGKTARPAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MDPILINAQVQLWSA----KAGMSKTR---------NALIEACIGKREVKLIL
YFNTGK-IKT-LQLYNNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARRLKRFL
DKIY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QGGIQPA-R-SD-ERCDEPST----SAH-GVN-GS---------------------
PPLEVHANASSKCFESPKGSEMCM---------------------FRELSLL--PSSST-
SLHSVGLLETQLIKRKRFL-PDL-A-KN--EKQ-SD-LKGNIR--EFEANLVVCISNETG
KERNV---RAIE-INNPGLGFPFETNY-----------PEDSGVDV------RD--LNDL
ITKLFSPVLLETR---------------------CIEN----------GLEWHDYMKTYL
LHPEKS-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSIPLF-INDLFNQGFPWIKAPKDDF-NMR
L-MQLLVLKDIYNARVRQRLLIGITRALPIF-GEIFTADRQN-DAHEFLSLCLVQLKE-T
FQRVTMMWQSENESGDFYLLKDI--FADYATINKMPICPVTN-NFEFELLS-SIFCKACG
LTL-FKGEPSRYLS-VNIPQGG-K--DM-SIQ-STLDLFFRAEEL------------EHR
CERCL-YNKSVSLHRFGRLPRVIIVHLKRYIFS-ESWVMKKDEQPVLVSKYLSLSCHCNR
STKPPPPLRPSEHAKN-LDLLKPFEVLGSEILKLPFNSV------------RTSRSQG-V
STVNIMSNSESETE--------SGKRVSEVL--SGKVQQENPGKGDTANIVGS----ELT
K-----------------------------------------------------------
--ETEKLKKHEKEH-IPS--HLDSDSISEA------------------QKY-RQA--EKC
N-----EGRSDKQISLEALTQSH----PKPVSQE--QT-ENRGEAT---LSHTQNGSQ--
-------------------------GSQGSSDSRKSPRRSDVLNKK-AKPTSKVNP-GKL
NKK-D-NVYRLVSIINHIGNSPNGGH-YISDAFDFK----RQSWFTYSDLHV-------T
KMQEDFVY-RGRSSTG---YVFFYMYNDIFEELLARETQSTSTSKG--------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MSSIMVPGYAQIWSK----RSGMSKTQ---------NVFLEAVKGRKNFKLLI
YFKTGK-VKT-FHLNNNIRSASFTSYGEDFTHLHLVFRNNGFLIVERLASTDAEQLKVFL
ASVP

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QDNSEPR-MNPDEEDNESVSA----STATQIS-ES---------------------
SLPSIYNKSDEECSGTNQESRKYI---------------------R-DTSLL--SSKSV-
LP-SKK--SKTQRGKNTMQSSDL-E-ANESEKFLIK----------YNANPLKYKSPNWK
KPSKA---KEVQSNKKAS--PVSVANV-----------LDDRSVGD------TN--LQNL
SENALRELLMALN---------------------YSAD---------S----SEPMLPSK
VYSQAR-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYINAVLQSL-CSIPLF-VNDVLNQRFPWARICHDIF-CLC
M-ALLLTMKDVFNMSIKEKLLVTIKKTLSLV-AEIFSMDAQN-DAHEFLSFCLDQMKD-G
FEMSSIFGRSE----YQSLPQQA--FSGDSA-TGMTGCPVVT-NFECELLR-SIFCKACG
QAV-YKTEPNNYLS-INLPQGK-KTQSL-SIQ-STLDHFFATEEL------------EYK
CAECK-HKRSDIVYKFSKLPRILIIHLKRYRFT-EVLSLRKDDQAVTIPTYLDLSSHCNE
STKLPVPLSRTAHIRN-MRLLLAFQKLSFSILCSLSLLKSE-------------APKN-S
RPKRDKSGKGSDSQ--------KPQRFLKGK--TVQQQ--------KVGKREA----DSA
CLESAVMPREQQLA-DSLMNLEDPYLPLFSRYSGTPFSS---SDTCLTE-TQ-----VQA
MPENRKVKKSGKTN-TFA--ESDFVSVSETTGDFSKDKKTRVTG--KSRKVTKQN--KGY
D-----ERGIHKDTPQHTLPEGI----PKPDAQK--HQ-VNVRGQT---ELNLQKA----
-----------------------------------KPGNKDSSRKK-TKS-KISEPEEKV
DNINP-HTYRLIGIISHLGSTLNSGH-YITDAYDFT----KQAWSTYNDLLV-------S
SISESQVK-KDRVSSG---YIFFYMHNEIFEELVLRLMTTQAEAQAEAQDQSQAQAQAQA
QAQAQAQSQAQAQAQAQAQAQAQAQSQAQAQAQAPAP-ARARARARARARARSRSRSQSK
SKAKSRSKSEARSNKAKKAS

-------MSSLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAAATKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLETKDDV
SFRKVLGNPGRGSIKTVAGSGTAV---------------------TRTVPSLVPSLMSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LSEDY-PKENDSSSNNK--AMTDPSRKYLSSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPFS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLIKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MDKLNKTWKTEPFPGEENSP-------DISV-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWNAHMAI-SRPLKASQTVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRFCDMSGNEQQQ--EVLEKDSKLCQIEPDK-SELE
NSGFDKMSEEELLTAVLEISKRETLPSLSHEDDDKPTSS---PDTGFAE-DD-----MQE
MSENPDTMESEKSK-TII--EPDPASFTEIAKDCDENKENKTPE--VSQGEVDWL--QQY
DM----DREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQAFSMEAGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MTPLKIHGPIRVRSI----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNAGGIPRT-FQLSHNIKNVVLRPNGAKQSRLILTLQDNSYLSIDKVPYKDADEMRLFL
DSVHQNRLHTA-MKPSQGSGSFGGVLGSRTTQKEAN-RQFPYVENQTSKKAS-LESKDDT
TYRKVLGTPGRGSIKTPTGSVMTG---------------------SRVNTSLTS---TSS
TPLRTGLLENRNEKRKRMLSTGS-E-MNEDY-PKENDSSSNNK--AMTDPSRKYLNSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAVSKDYSTGNSNLDR------TSVSSQTP
SAKRSLGFLSQPAP-------------LSVKKLRSNQD----------YTGWNKPRVPLS
THSQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKVPLNAL-I-R
RFAHLLAKKDVCNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPISGEENSP--GRTSDDIAA-TRIYTCPVVT-NLEFEVQH-SIICKVCG
ETV-HKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKSAIVTHKFNRLPRVLILHLKRYSFNVALSLNNKVGQQVVIPRYLTLSSHCTE
NTKPPLTLGWSAHTAI-SRPLKASQMVNSCTISTSTPSR----K-------YTFKSKS-S
AGFSIDSDSEDELLKRSVV---LNQRLFEMPSREQQ---EDLEKVSKKCKMESDK-SDLG
NSGFDGMSEDELLAAVLEISKREASLSLTNEDDDKPTSS---PDTGFAE-DD-----IQD
MPENLESMEAEKSK-API--EAGPASFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEEELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SFLDGMGSDDDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYDIK----KQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKDIFDELLETEKASQLLSLEAGRTTRPAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1105)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPVEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTATGSGITV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTGSKDYSSGSTNLDS-----RTNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSS-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGCEQQQ--EDLEKDSKSCRIEPDK-SELE
NSGFDGMSEEELLAAVLEMSKRESSPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENQEPVETEKPK-TVT--EPDSASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MEPILINAQVQMWSA----KAGMSKSR---------NALIETCIGKQEVKLIL
YFSTGK-IKT-LQLHDNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARKLKRFL
DKTY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QGNIQPA-R-SD-ERCGEPST----SAQ-ELN-GS---------------------
GS---SCETNSECFESPKESEMCM---------------------FRELSLL--PSSST-
FLHNVGLLENQLIKRKRFF-SDL-A-KN--EKQ-SN-LKDSIR--DFEANLVVCISNEKG
KERNV---REVD-ISKPGFGFPFETNY-----------PEDSGVDV------RD--LYDL
ITKLFSPVLLETH---------------------CIEN----------GLEWHEYMKTYL
LYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSIPLF-INDLFNQGFPWIKAPKDDF-NML
L-MQLLVLKDIYNARFRQKLLIGITKALPIF-GEIFAVDRQN-DAHEFLSLCLVQLKE-T
FQRVTMMWQSENESGDFYLLKDI--FADYATINKMPVCPVTN-NFEFELLS-SIFCKACG
LTL-FKGEPSRYLS-INIPQGG-K--DM-SIQ-STFDLFFSAEEL------------EHR
CEKCL-YNKSVSFHRFGRLPRVIIVHLKRYHFN-ESWVMKKDERPILVSKYLRLSCHCSK
STKPPPPLRPGEHVKN-LDLLKPLEVLGSEILKLPFNSV------------RTSRSKG-F
ETINITSNRESEAQ--------SEKRVSEVL--SGKVQQGNSGKGDTAHIVGS----ELT
K-----------------------------------------------------------
--ETEKLKKHEEEH-RPS--DLDSGSIREA------------------QKY-QQA--EKC
N-----EGRSDKQISLEALTQSR----PKPVSQE--QT-ENLGKTT---LSHTQDSSQ--
-------------------------SSQSSSDSSKSSRCSDDLDKK-AKPTCKVDP-TKL
NKKED-NVYRLVNIINHIGNSPNGGH-YINDAFDFK----RQSWFTYSDLHV-------T
RTQEDFVY-RGRSSTG---YVFFYMHNDIFEELLAKETQSTSTSKG--------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIA-----------------------RTIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRAYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDSKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------TSPHKVHGFVQTWNK----RTGPSKLK---------EPIAETVEREKDIQLIF
MFQGGKPIDIN------I-LECFSHYGERQNGLYLTFWEKT-LCLGKLSRTHTEQLQIFL
GIIRQNKYQWP-IKLETYWGVMESM----NAYTEPD-KT---------------------
PSSNVCRVPSAETFTTEEGSGTTF---------------------PQQ---L--LGKSP-
MLAKQGLPEKKDRKRKTTLSSSL-D-TDEGF-LEEN-ESVPSK--KFKKD----------
---SL---KDLAKDGSSKHGPSLRTAS-----------PGNSPLDE-----TVL-SPQSV
SDK-SLLLPSVPE---------------------RAQD----------DPQHDQDQLCLD
SHPEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNSILQSL-YAIPSF-ADGLLGQGIPWENIPSDVL-IMP
L-SMLLALKDICNLETSQDLLRDIKNAISAV-AEIFSGNMQN-DAHEFLCQCLDQLKG-D
FEKVNTIWKTRREAGDENSPPEL--LAGDAA-TKVFVCPVAA-NFEFELQD-YVICKACG
QVA-VVIEPGNCIS-VNLHPKP-KASPL-SLQ-NCFDLFFTTEEC------------ERL
CETCN-HKKAVVMHKFGRLPRVFIVHLKRYSLS-DTYALMKDDQQVLIPKYLSLSSNCNE
DTRPPLPLDSNAPVLD-PEVLNLTQEVISERVSPCTSSV----K-------LTWQSSD-S
SVLHVAPDEDAEQN--------TPQRIWQAR--PKEKQQSDLASGS---NLES----KLG
NARDREVREMEMLAAASVMDQGDISLLMNCEDESNPINN---PDRGLEE-VY-----CQE
EPENPEPKDNEKTS-TLV--ELDLDHVSESSKDLCDYEKHKISE--GLRGVVEQLH----
------------------------------------------------------------
-----------------------------------ESVTKDIVGMEKTIA-KVKEPKRSM
QMGDALHSYRLISVISHIGNSPCAGH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTSQQEEVFLPGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MNPLQIHGFIQVWSK-----TGMTRLK---------EALIETVEGEKDIKLV-
-------------LSNNFRSVVLRYCEERQSCLHLTLQNNITLLIDKLSFHDAEQLKMFL
DLVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKFQES-MKPDNDQAVFESR----NTQKGID-KT---------------------
LFYKI---------------RMLF---------------------SQKMPFL--TPKSS-
TLVNESFLENRGEKRQKPLSSGL-E-MNEDF-LKKN-DFTLNK--KLKMNSSKYVTSNRK
EPSSL---KDLEKDRNLKLGSSFKPNS-----------NRNPNVET-----TVL-STQTF
SAKTICALPSEKE---------------------SSQD----------DLRWKNTQVSFD
CHPEKL-WK

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAILQSL-FAVPSF-ADDLLTQGLPWEKIPSNTV-IMS
L-SMLLAFKDICNSKTQAELLVNIKNAISAV-AEVFSGNMQN-DAHEFLGQCLDQLKE-D
IKKLNSGLKTEREPEDENSSPRM--YAGNAV-TKVLIYPVVA-NFEFELQL-SIICKVCG
HAV-LKTELDNYLS-INLHQEE-KTLPS-SIQ-NSSDLFSKAEEL------------EYN
CEMCK-HNSSVAMHKFSRPPSVLIVHLKRYSFN-DAWLLAKNDQQIYIPKYLSLSSHCDE
STKSPLPSSSNVPVGG-CKALKTSQELVPEIISPSTLLA----K-------STSEPTD-S
LVLHVAPDKNADLQ--------RFQRNCEDV--NQEHHQRDLENGS---KPQS----KLV
NSEDKMVSEKELPVADSVVDQGDNSLPTICEDTGKPVGS---PDTDLIE-TC-----LQE
VPENPERKKCEETN-TSV--ELDFDTVTESASGFYEHKGNRIPE--RSQGMAEEL--RQC
T-----EKRTSEKRLQQASPPPPGSPTRKPNTQE--HADEALGGST---ALRLQKANV--
-------------------------NSLGALGSDKSPGNKSIVEMENTEA-EAKEPRRNV
KMRSPLQVYRLISVVSHIGNSGDSGH-YISDAYDFR----QHSWFTYDDLWV-------S
EIPETLIQ-EARLHSG---YIFFYMHN-------E-ADNSQQLGTQAGVIPQGE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKPSQGSGSFGAILGSRASQKETN-RQLSYSDNQTSSKRGSLETKDDI
PFRKVLGNPGRGSIKTVSGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRMLSSDS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEDNRTSGLLPLQSSSFYGSRAGSKDYSSSVTNLDR------TNISSQTP
SAKRSLGFLPQPIP-------------LSVKKLRCNQD----------YTGWNKPRVPFS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKIEPIPGEENSP-------DISA-TRVYTCPVIS-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTTV-SRPLKTSQMVNSCITSPSTPSK----K-------FTFKAKS-S
LALYIDSDSEDE-LKRSVA---VSQRLCEMSGNE-QQ--EDLEKDSKLCRVESDK-SELE
NSGYDRMSEEELLAAVLEISKREASPTLSHDDDDKPTSS---PDTGFAE-DD-----IPE
MSENPDTVEAEKPR-TVT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDIFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQETAVQ-TDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEAGKTARPTS-----
------------------------------------------------------------
--------------------

-----------------------------

PF16674 // ENSGT00440000033542_0_Domain_0 (30, 125)

MSKTK---------SVCIESTVGKREVKLLL
YFSTGK-IKA-LQLNNNIKSVILRTYGDNQNYLHLTFKNNDFLFVEKLNTTDARQLKRFL
DKVY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QKNLRAS-KRNDEETSGGPST----STE-ELG-GS---------------------
SSLEVHSEAGSKCLESAKES---------------------------EVPLP--SSSPA-
TLSSMELFGKQLIKRKRSL-PDS-E-K--KGKE-NI-PKDSSR--ECEAKSVVPVHDDKG
KERDL---GEAE-MSKPGFGFSFETNY-----------SEESDSDI------HN--LHDL
IRKFFSPFLLEPH---------------------CVQK----------GVEWHECMKTLL
LYPEKA-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSVPLF-VNDLFNQGFPWIKPPTDDF-NMR
L-MQLLVLKDIYNTKTRENLLISITKALPEL-ADAFIADTQN-DAHEFLSLCLVQLKE-T
VQKLTVLWQSESESGGNSLLRRI--FAGHAIVNKIPVCPVAN-NFEFELLR-SIFCKGCG
LAV-FNKEQSSYLS-INIPQGL-KGQNL-SIQ-SSFDLFFKAEEL------------EHR
CERCM-HNRSIALHKFGSLPRVIILHLKRYSFK--SQVMKKDEQHIIISKYLKLSFHCNR
NTKLPQPLSQNAHVKD-LDLLKPLQELGSEILEFSFNSL------------RASRFKD-F
TTGDTRSDNESEAQ--------NVKIVSKVL--SGKGQQEDQRYGDTANVIGS----ELT
N-----------------------------------------------------------
--ETGNLKKHKKVD-LLR--KLDSGRISEATEE----SDIRIPE--RSPKY-QQA--QKC
S-----EERRDKQTSGEAVAQKH----PKPRSRE--QI-ESTRKPA---EAHTQNGKL--
-------------------------KSQGSLDSSRNPGNKDGLGKK-RKSKVK------V
SDKEE-NAYRLFNIISHIGSSPQGGH-YINDAFDFR----KQDWFTYSDPQV-------T
STQEDLVC-KARLSTG---YVFFYMHNEIFEELLARETRSRKMSQK--------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MEPILINAQVQMWSA----KAGMSKSR---------NALIETCVGKREVKLIL
YFSTGK-IKT-LQLHDNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARRLKRFL
DKTS

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QGSIRPA-R-SD-ERCGEPST----SAQ-ELN-GS---------------------
GS---SCETNSECFESPKESEMCM---------------------FRELSLL--PSSST-
FLHNVGLLENQFIKRKRFF-SDL-A-KN--EKQ-SN-LKDSIR--DFEANLVVCISNEKG
KERNV---REVD-ISKPGFGFPFETNY-----------PEDSGVDV------RD--LNDL
ITKLFSPVLLETH---------------------CIEN----------GLEWHEYMKTYL
LYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSIPLF-INDLFNQGFPWIKAPKDDF-NML
L-MQLLVLKDIYNARFRQKLLIGITKALPIF-GEIFAVDRQN-DAHEFLSLCLVQLKE-T
FQRVTMMWQSENDSGDFYLLKDI--FADYATINKMPVCPVTN-NFEFELLS-SIFCKACG
LTL-FKGEPSRYLS-INIPQGG-K--DM-SIQ-STLDLFFSAEEL------------EHR
CEKCL-YNKSVSFHRFGRLPRVIIVHLKRYHFN-ESWVMKKDERPILVSKYLRLSCHCSK
STKPPPPLRPGEHVKN-LDLLKPLEVLGSEILKLPFNSV------------RTSRSKG-F
ETINITSNRESEAQ--------SGKRVSEVL--SGKVQQENSGKGDTAHIVGS----ELT
K-----------------------------------------------------------
--ETEKLKKHEEEH-RPS--DLDSGSIREA------------------QKY-QQA--EKC
N-----EGRSDKQISLEALTQSR----PKPISQE--QT-ENLGKTT---LSHTQDSSQ--
-------------------------SSQSSSDSSKSSRCSDDLDKK-AKPTRKVDP-TKL
NKKED-NVYRLVNIINHIGNSPNGGH-YINDAFDFK----RQSWFTYSDLHV-------T
RTQEDFVY-RGRSSTG---YVFFYMHNDIFEELLAKETQSTSTSKG--------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 119)

MPFLKMHAFVCICSR----KTGTTKER---------EAVVETVEGEEEISLQ-
SFAAEECIQV-FQLNNNS--------TNRESCLNLTLPNSRSSMTDKWSHRDAGGLRM

ENSGT00440000033542_0_Linker_0_1 (119, 429)

FQ
-------SQPP-KIPNSDWAVLDRR----STQKERD-KT---------------------
PFHY----------------EIPF---------------------PPKMTLL--MSKPP-
TLVRTGLLEHQGTKRKKTPLSGL-E-MNEGS-VEEN-NPGPNK--TSKTASSEHISSNRK
TPSHL---KDPTKQRNSKRGPSGKATS-----------TENPNLEE-----PVL-SIQTL
SSKRSLEFTSEQI---------------------HSPD----------VSRWNEPQAPLN
TYPEQL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NVGNTCYMNAILQSL-FATPSF-TDDLLMQGVPWEKIPFDAL-IMC
V-SQLLALKDICDVETKGEQLVNVKRTISAV-AETFSGNMQN-DAYEFLGYCLDQLKE-D
MAKLNTALETERETWLDSSSLKT--YANKAAPQQAFLCPVVA-NFEFELQH-SIICQACG
QIV-VKTEPNNYLS-INLPQET-KLPSF-SIQ-NSFDLFFRAEEL------------EYS
CKACK-HKTAVGMRKFSRLPRVLIVHLKRYSFD-DVWLLVKDNQQVDIPKFLSLSSHCNE
STKPPFPIARDVPPGN-PQILNLPPEVISEFN-TLTPSV----K-------WISEPSD-S
LARTAQPQ---------------------IT--SQEQQQTILENGSKRDITES----GWA
DSGDGKVPEKELPTAGSGMDQGDTCL-MICEEEREPTSS---PHTSPTK-IC-----SQV
GPEDPEHEKYEEIN-TLV--DLDFDNVTQSADDFCKANENRIPE--RSQGVAEQL--QQC
H-----VE---LELHQQEPPLTV----RILDSQE--HTEKDFKSQ----------QDL--
-------------------------HSLGALGSDTNA---GILDPEDTEA-EAKALKSNA
EAGDPLHTYQPISVVSHLGSSPDSGH-YISDVYDFQ----KQAWFTFNDLQV-------S
EIDESVMR-EARLRTG---CIFFYMHRDIFQALLGKTRNSQLLAMWKGEIPQEE------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEVVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLETKDDT
PFRKVLGNPSRGSIKAAAGNGVTP---------------------TRTIPP----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTATKDYTPGSTNLD------RTNISSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKIEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKVCG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFNLGWSAQMAV-SRPLKASQMVNSCITSPSTPSK----N-------FSFKSKT-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGSEQQQ--EELEKDSKSCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDSVETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTES-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALNLEVGKTTRQVS-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKESN-RQLSYSDNQASSKRGTLETKDDI
AFRKVLGNPGRGSIKTVAGSGITL---------------------NRTVSS---LTSTS-
TPLRSGLLENRXXXXXXXXXXXX-X-XXXXX-XXXNDSSSNNK--AMTDPSRKYLASSRE
KQLSL---KQSEENRTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----TNV-SGQTP
SAKRSLGFL---------------P-----QPAPLSVKKLRCNQD---YTGWNKPRIPLT
SHQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 517)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNALIR--
RFAHL-VKKDICNSETK-KLLKKVKNAISAT-AERF

ENSGT00440000033542_0_Linker_1_2 (517, 845)

SY-MQN-XXXXXXXXXXXXXXX-X
XXXXXXXXXXXXXXXXXXXXX--------XXXXXXXXXXXXX-XXXXXXXX-XXXXXXCG
EIIPKREQFND-LS-IDLPRRK-KPLPPRSIQ-DSLDLFFRXXXX------------XXX
XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKN-S
LALCLDSDSEDE-LKRSVA---LSQRLCEVS--GNELQQEDLEKDSKLCRLEPDK-SELE
-SGF

PF02809 // ENSGT00440000033542_0_Domain_2 (845, 864)

DRS--EEELAAVLEISRREASPSLSHEDDDKPTSS---PDTGFAE-DD-----VQE
MPENPDTVETE-KPKSIT--EPXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX--XXX
XX----XXXXXXXXXXXXXXXXX----XXXE-AWE

PF02809 // ENSGT00440000033542_0_Domain_4 (996, 1016)

QKEDDDLKRATEL---SLQXXXXXX
XX-----------------------X----XXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX----XXXXXXXXXXXX-------X
XXXXXXXX-XXXXXXX---XXXXXXXXEIFDELLETEKNSQALSMEVGKTPRQAS-----
------------------------------------------------------------
--------------------

-------MTPPEVCGVVQTWSK----ATGITNEK---------EALIKMVEREKDSRLVV
TFNSGRCARV-FHLSNNTTSMVFRPSREEQSSLQLTFRNNSSLLVSKLSRTDAKKLKKFL
KRVLRKTSQPS-MKPSHEWRVLGGW----KTQEKSN-KN---------------------
FCHRVCNNPSN-----------------------------------QEMPSL--MPKSS-
TVVRTGLLENPCDKRKRRPL-------SEDI-LKKN-NSVLNE--KSKTDSLKCVNNYRK
EQLSL---EDLEEYVKSEIGPSFDTSS-----------TRNPNLDE-----NIL-SNQHL
SAERTFAFPLEPN---------------------CSQN----------EPELNE----TN
SHLE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QE-WQGLP--NLGNTCYMNAILQSL-FAVSSF-ADDLLNQEIPWNKIPFDAL-IVC
F-SQLLVFKGLCDIQIKGELLVNIKNSISSA-AATFSGNMQN-DAHEFLNQCLDQMKE-D
MEKLNVM-T--KMETEEISCPQV--SAVNAS-TKVFVCPVVS-NFGFELQH-SITCKACG
EVV-CKTELSTCLS-INLSQET-QSLSS-SIQ-HCFDLFFGAEEI------------EYN
CEKCK-HKHSVAMHKFSRLPRVLIVHLKRYMFD-DCGDLVKNNQQVEIPTYLNLSLHCDE
NTKPPLPLGSNAYIED-SQVLNVSQDMISGTVSSWTLPM----M-------STSTFQD-S
LVPHVGSDKDTEPQ--------KCQRLSGES--SQEQQKRDLENGSKLNITES----ELL
NSRDGPASEKGWPVADSTIYQE-NFLSVTCEHGDKLTSI---PVTAVVE-AH-----LEQ
MPESPKSKTSQTTN-TTV--KMDSDSITESTEDFHEDKENRNPE--RSQGAVEHL--QPC
D-----EKRKYKEVLQQALPQSL----GKPNTQE--HTEEDLSGST---ELNLLKDSL--
-------------------------NSLRPLGSGENPGNRDILGMENIEA-DAEELKRND
SAGDPYHAYRLISVISHLGGSPNSGH-YVSDVYDFV----KQAWFMYDDLQV-------L
QIQEANMQ-KNRCCNG---YIFFYMHNDICDVLLRKAKTSQSPSTESLKMIFHMEEDSSL
L-RFF-------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGVKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKPSQGSGSFGAILGNRPSQKETN-RQLSYSDNQVSSKRGSLETKDDT
PFRKVLGNPGRGSIKTVAGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--VMTDPSRKYLISSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSSVNNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 727)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPTPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVTLSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPF

ENSGT00440000033542_0_Linker_1_2 (727, 848)

TLGWTAHATI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LSLCIDSDSEDE-LKRSVA---VSQRLCEMSSSEQQQ--EDLEKDSKLRRIEPDK-SELE
NSGFDRM

PF02809 // ENSGT00440000033542_0_Domain_2 (848, 863)

NEEELLAAVLEISKR

ENSGT00440000033542_0_Linker_2_3 (863, 971)

EASPTLCHED-DKPTSS---PDTGFAD-DD-----IQE
MSENSDPVEAEKPR-TVT--EPDPASFTEIAKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EPER

PF02809 // ENSGT00440000033542_0_Domain_3 (971, 990)

EEQELQQALAQSL----QE

ENSGT00440000033542_0_Linker_3_4 (990, 998)

Q-EAWEQK

PF02809 // ENSGT00440000033542_0_Domain_4 (998, 1015)

EDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDIFDMEYTEA-EAEELKRNA
E-----------------------------------------------------------
---------------------------EIFDELLETEKNSQALSMETGKTAQPTS-----
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------MRG---------------------HRVVPREAP---GSS
PFSRRGH-------------RGP-E-KRSDS-PTVTQLTSGRAGSRTRGPRLPSPGSCHR
ATLGA---GYGSEAGPRGTR------W---VAGSLPFKVPSPFPRR------SGVSSQTP
SAKRSLGFLSQPAP-------------LSVKKLRSNQD----------YAGWNKPRVSFA
THPQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 602)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLSKKDVCNSETKKDLLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPGSGEENPPGPGRPAEDGAA-GRVYTCPVVT-NLELEVQH-SIVCKACG
ETV-PRREQFNNLS-IDLPRRK-KPLPSRSVQ-DSLDLFFRVRTP------------RRL
GTRRA-APRGGL------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MEPILINAQVQMWSA----KAGMSKSR---------NALIETCIGKREVKLIL
YFSTGK-IKT-LQLHNNIKSVVLQTYGEDQNYLHLTFKNNDFLFVEKLTTTDARKLKRFL
DKTY

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QGSIQPA-R-SY-ERCGEPST----SAQ-ELN-DS---------------------
GS---SCETNSECFETPKDSEMCM---------------------FQELSLL--PSSSA-
FLHSVGLLETQFIKRKRFF-SDL-A-KN--ENQ-SN-LKDSIR--DFEANLVVCISNENG
KERNV---REVD-ISKSGFGFPLETNY-----------PEDSGVDV------RD--LNDL
ITKLFSPVLLETH---------------------GIEN----------GLDWHEYMKTCL
LYPEKL-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NVGNTCYINVVLQSL-CSIPLF-INDLFNQGFPWIKAPKDDF-NMR
L-MQLLVLKDIYNARFRQKLLIGITKALPIF-GEIFAADRQN-DAHEFLSLCLVQLKE-T
FQRITMMWQSENESGDFYLLKDI--FADYATINKMPVCPVTN-NFEFELLS-SIFCKACG
LTL-FKGEPSRYLS-INIPQGG-E--DM-SIQ-STLDFFFSAEEL------------EHR
CEKCL-YDKSVSSHRFGQLPRVIIVHLKRYQFN-ESWVIKKDERPILVSKYLRLSCHCSK
ITKPPPPLRPGEHVKN-LDLLKPFEVLGSEILKLPFNSV------------RTPRSKG-F
STINIRSNRESEAQ--------SGKRVSEVL--SGKVQQENSGKGDTAHIIGS----ELT
K-----------------------------------------------------------
--ETEKLKKHEEEH-RPS--DLDYGSIREA------------------QKY-QQA--EKC
N-----EGRSDKHISLEALTQSH----PKPISQE--QT-ETLGKTT---LSHTQDSSQ--
-------------------------GSQSSSGSSKSSRCSDDLHKK-AKPTYKGDP-TKL
NKKEE-NVYRLVNVINHIGSSANGGH-YINDAFDFK----SQSWFTYSDLQV-------T
RIQEDFVY-RGRSSTG---YVFFYMHNDIFEELLAKETQSTSSSKG--------------
------------------------------------------------------------
--------------------

-------MAPLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNVGGIPKT-FQLSHNIKTVTLRPNGRKLCCLMLTLKDTSFLTIDKVPFKDANEMRMYL
DAVHQDRVHTA-GKASQGSGSFGGVLGSRTTQKEAN-RQFSYIENQPPPKRVTVESKDEN
PFRKVLGTPARAPVKNSAGTGAPS---------------------NRVNVTASP---ASS
TPHRTGLLENRSEKRKRAQPPGS-E-ISEDY-PKENDSSTNNK--ALSDPAWKYLNSSRE
KQLNL---KQAEENRTSGILPLQSSSFYGSRSSPKEYSTGSSTLDR------SGVSSQNP
SSKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
THPQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVCSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVPNDDNSP--GRASDDLSA-TKVYTCPVIS-NLEFEVQH-SIICKMCG
ETV-TKREQFNDLS-IDLPRRK-KLLPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRLPLTLGWSAHSAI-SRPLKASQMVNSCTISTSTPCR----K-------YTFKSKS-P
TALYVDSDSDDEPLKRSVA---HSQRLCNIQTRDQQQLQEEQEKGSKRSKMEGDK-PELG
NAGFDGMSEDELLAAVLEISKREASLSLNH-DEDKPTSS---PDTGFGD-DE-----IQE
LPENLETMEMEKPK-AAL--ESGPANFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGNEDVLDMEYSEA-EAEELKRNA
ETGELPHSYRLISIVSHIGSTSSSGH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLETTVQ-CDRDRSG---YIFFYMHKDIFDELLETEKNAQPLSMEVGRSIRQPL-----
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLTHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKP-QGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDV
PFRKVLGTPSRGSIKTTPGSGIPV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LSEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTGSKDYSSGSTNVDS-----RTNVPSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHPQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-L-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
TTKPPLNLGWSAHMTV-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKSSS
LALCLDSDSEDE-LKRSVA---LSQRLCEVSGGEQQQ--EDLEKDSKLCRLEPDK-SELE
NSGFDGMSEEELVAAVLEISKRETSPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPEPVETEKPK-AVT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDIKRAT---ELSLQEFNS--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELMETEKNPQALNMEAGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPVEPDR-SELE
NSGFDRMSEEELLAAVLGVSKRDASPSLSHEDDDKPTSS---PDTGFK------------
------------PK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MAALFLHGFVQIGNC----KSGMSKSK---------ESFTEAVEGRKKDRLVL
YFKNGK-CNT-FQLSDNIQNVVLRSCRGNQNHLHLTLQNNNVLFVEGLSSTDAEQLKTFL
DRVHQNKVQSP-VRPGKGRNVFSST----TTQKEIN-KT---------------------
SFHRVDEKSSRKSFEIAKGS-GTG--------------------VLQRMPLL--TSKSS-
TLTCGELPENQHKKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADRLRCVSYNRK
KQLKL---KELEENKKLECESSCIMKA-----------TGSPYLDD-----IGF--LQAL
TEKMVLAFLLQPG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-

PF00443 // ENSGT00440000033542_0_Domain_1 (428, 1164)

CHGLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-ARLLFLKDTYNIEIKEMLLLNIKKAISAV-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFVEDNFPKRV--FADDPD-TNGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQGM-KARPS-SIQ-STFDLFFGAEEL------------EYK
CAKCK-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFCSLKKNGREVVISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGSISVSWPST----K----------EPKD-I
LASHIGSDTESEHK--------KGQTVLKGA--SRRQQQKYLGKNFKPNEPE------SV
YSGDRAFIEKELLA-HLMAYLEDTSLCQFHKAGGKPASS---PDTCLAE-VH-----FQT
VPENPKRKKYVKTS-KFV----AFDSIINRTKDLYEDKNVRIPE--KFQKVSEQT--QQC
D-----AMRICEQAPQQALPRSF----PKPGAQG--HT-KNLIKPT---KLNLQKPNR--
-------------------------NSLPALGSNKNPRNKDILDKIK--S-KAKETKRND
DK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYNDMQV-------L
GIQEAQMQ-EDRRCTG---YIFFYMHNEIFEEMLKREENAQLKSKEVEETLQKE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSSIMVHGYAQIWNK----RTGMSEPQ---------GVFIEAVKGRKNFKLLI
YLRTGR-VKT-LKLNNNIKSVILQSYGANLSSLHVTFQNDGFLFVEKLSSTEAKQLKAFL
DSVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NCPEPH-MSPDKGEG--PST----CTGTQTR-KT---------------------
SLPKVREESGEGCSGTDKNRKRSA---------------------HRKKPLA--TSKSS-
TLTNEE-LENQQRKKKRMLPSDS-E-VNENEKSPIK-KNIVRE--KSNANPLKYKSYTWK
KQIKP---RKFKSNEKLA--SLLKANY-----------LEKPSVDD------TD--LQFL
TKSTLRQFQLALK---------------------CSEG---------G----SKLGLPRR
VYQQTV-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYINAVLQSL-CSIPLF-VNDVLNQGFPWGRISHDIF-SLC
V-ALLLTMKDIFNMRIKEKLLVTIIKAISVV-AEIFPMDAQN-DAHEFLSYCLGQMKE-A
LQKPNVVLDSENEFQEENSPQQV--FAGDSA-AGVPDCPVMT-NFECELLH-SIFCKACG
QAI-YKTEPSNYLS-INLLQGM-RRRPL-SIQ-STFDHFFATEEL------------EYK
CENCK-HKRSVVVHKFSRLPRVLIIHLKRYCFN-EFLSLRKDDQAVTVNKYLDLSSHCKE
DTKPPVPLSKNAHIRD-LQLLKLFQKLSLTVICSLSSVK--------------SKSKN-S
VAKRVKAGKKPEPQ--------KSQHFLKGK--RRAQQQKDQ---GKPCMRES----EST
CLGDGASVEKKQLA-ISVMNLEDTSLPLSYRYADKPARR---PDT---E-AQ-----FPG
VPEHPKLKKSKKSN-RFA--ESDFDSVSQTTEDFSKNKKARVSE--RSQTVAEPI--DHP
D-----GMEIHKGDLQQILPEGF----PMPDAQE--HR-MNLRGCK---ELNPQKA----
-----------------------------------NPGNKDILVKK-TES-RTQKPGKKA
DGKGP-HTYRLIGIISHLGNSHNSGH-YISDVYDFK----KQVWFTYNDLLV-------S
RISESLVQ-KARLCTG---YIFFYMHNEIFEELLLRIKTSQSQFKCEPKSRSTK------
-ARKRS------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGIKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKASQGSGSFGTILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDEI
PFRKVLGSPGRGPIKTVTGGGMAV---------------------TRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDR------CNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YAGWNRPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDICNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENSP-------DTSA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKLGQQVIIPRFLTLASHCTE
STKPPVTLGWSAPMAI-SRPLRACQMVNSCITSPSAPSK----K-------FTFKSKN-S
VTSCLDSDSEDE-LKRSVV---LSQRLCDLPGNEQYQ--EDVEKDLKLCRLEPGK-AELE
NSGFDRMSEEEVLAAVLEISRREASPVLSPEDDDKPTSS---PDTGFAE-DD-----IPE
MPENPDAMEIEKSK-TIT--EPGPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DV----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGALPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS-----
------------------------------------------------------------
--------------------

-------MTSLKVNGFVQIWSK----KSRMTKSK---------EAFIEVVGREKEIRLVV
SFKYEQLIRI-FQLKNNIKSVVLRHRRDKQNHLHLAFRNNCSLFINKLSYRDAKELKTFL
DTVHQNKFQTP-MKLDSDGGAFDRR----ITQKKIS-KT---------------------
PLHKASDLLSYRSFNTKKRIGTPV---------------------LQKIPSL--MSESS-
TFERSGLLENQCGQGKRMLSSCL-E-VNEDF-LKEY-NPI-LK--KHKTDSLTYINSNKE
KQFNL---KEVEMDGTLKHRLSLKSNS-----------PGNANLDE-----AAF-SVQTL
YAKGSLELPLGPK---------------------HSQN----------DPGQNKPQVPHD
SYPEPR-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAILQSL-FAIPSF-ASDLLRQGVPWENIPYDAF-IMC
L-SQLLVLKDICIPEVKEELLVNVKKSISAV-TEIFSGSMQN-DAHEFLGQCLDQLKG-D
MEKLNTIWKTEREPEEKELFPQI--SASEAA-TKVFVCPVVT-NFEFELQR-SIICKGCS
QVI-FKKELSNYLS-INLPQET-RSLPS-SIQ-YFFDLFFKAEEL------------EYN
CEKCK-HKNSVAMYKFSRLPRVLIIHLKRYCFN-DVWLLVKDDQQIDIPKYLCLSCHCDE
STKPPLPLGDNANTGD-SKILKVPQEIFSGTICPSTPSL----R-------LISESKH-S
QVLYRSSDKKAEPQ--------IGLGLCKGS--SQGKQQRGQESGSELNMRKS----ELI
NSENGTASKKELLGADSVMGQVDNSLSMICEDGGKPTIS---QDTGLV-----------E
VPENPELKKYKKTN-SFV--ELPFDGILESTEKFYEDKENRFPL--GSQGVAAKL--PLC
D-----GKRTHEEFLHQALPQSL----RKLNAQK--LTEEDFIRAT---ELSIQKANV--
-------------------------NSPGI-----------------TEV-KAKELKRNA
NMGDPLHAYQLISVVSHLGSSPDSGH-YISDVYDFE----RQTWFTYSDLHV-------S
EIQESTMQ-EARLGNG---YIFFYMHSGIFEELLEKKKH---------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHGA-MKPSQGSGSFGAILGSRTSQKEIG-RQLSYSDSQAPAKRGSLETKDDI
PFRKVLGSPGRGSIKAVAGSGIAV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMLSTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEYCPSGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKHSVA---LSHRLCEMSGSEQQQ--EDLEKDSKLCRIEPDK-SEME
NSGFDRMSEEELLAAVLEISKREASPSPSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TMT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDTLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQSWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQTLSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDSKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKASQGSGSFGTILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDEI
PFRKVLGSPGRGPIKTVTGGGMAV---------------------TRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAASKDYSSGGSNLDR------CNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YAGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENSP-------DTSA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETV-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKLGQQVVIPRYLTLASHCTE
STKPPFTLGWSAHMAI-SRPLRACQMVNSCITSPSAPSK----K-------FTFKSKS-S
VTSCLDSDSEDE-LKRSVA---LSQRLCDLPGNEQYQ--EDVEKDLKLCRLEPRK-PELE
NSGFDRMSEEEVLAAVLEISRREASPGLSPEDDDKPTSS---PDTGFAE-DD-----IPE
MPENPDAMEIEKPK-TIT--EPGPASFTEITKDCDENKENKTPE--GTQGEVDWL--QQY
DV----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MAPLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNVGGIPKT-FQLSHNIKSVTLRPNGRKLCCLMLTLKDTSFLTIDKVPLKDANEMRMYL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

DRVHTA-GKPSQGSGSFGGVLGSRTTQKEAN-RQFSYIENQAPPKRVTVESKDET
PFRKVLGTPARASVKNSSGTGAPS---------------------NRVNVAASP---TSS
VPHRTGLLESR-EKRKRAQPPSS-E-MSEDY-PKENDSSTNNT--AMSDPAWKYLNSSRE
KQLKL---KQEEENRTSGVLPLQSSSYYGSRSSSKEYSTSSSTLDR------SSVSSQTT
SAKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
THPQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVSSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVPNDDSSP--GRASDDLSA-TKVYTCPVIS-NLEFEVQH-SIICKTCG
ETV-TKREQFNDLS-IDLPRRK-KLFPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRLPLTLGWSAHSAI-SRPLKASQMVNSCTISTSTPCR----K-------YTFKSKS-S
AALYVDSDSDDEPLKRSVA---NSQRLCNIQCRDQQPLQEEPEKSSKRSKMEGDK-PELG
NAGFDGMSEDELLAAVLEISKREASLSLSH-DEDKPTSS---PDTGFGD-DE-----IQE
LPENLETMETEKPK-APL--ESGPANFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGNEDVLDMEYSEA-EAEELKRNA
ETGELPHSYRLISIVSHIGSTSSSGH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLETTVQ-CDRDRSG---YIFFYMHKDIFDELLETEKNAQPLSMEVGRSIRQPL-----
------------------------------------------------------------
--------------------

-------MALLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVNLVV
HYNVGGIPTT-FQLSHNIKTVTLRPNGRKLCCLMLTLKDTSFLTIDKVPFKDANEMRMYL
DAVHQDRVHTA-GKPSQGSGSFGGVLGSRATQKEAN-RQFSYIENQTPPKRVTVESKEEN
TFRKVLGTPARGSIKNSPGAGTPS---------------------NRVNISAPP---ASS
VPHRTGLLENRE-KRKRTTPPGS-E-MSEDY-PKENDSSTNNK--ALSDPAWKYLNSSRE
KQLNL---KQAEENRTSGVLPLQSSSFYGSRSSSKEYSTGSSTLDR------SSVSSQTS
SAKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
THPQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVCSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVPNEDNSP--GRASDDLSA-TKVYTCPVIS-NLEFEVQH-SIICKMCG
ETV-TKREQFNDLS-IDLPRRK-KFLPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRLPLTLGWSVHSAI-SRPLKASQMVNSCTVSTSTPCR----K-------YTFKSKS-S
AALYVDSDSDDEPLKRSVA---HSQRLCNIQSRDQQQLQEEPEKGSKRSKMEGDK-PELG
NAGFDGMSEDELLAAVLEISKREASLSLSH-DEDKPTSS---PDTGFGD-DE-----IQE
LPENLESMEMEKPK-TLL--DSGPANFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGNEDVLDMEYSEA-EAEELKRNA
ETGELPHSYRLISIVSHIGSTSSSGH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLETTVQ-CDRDRSG---YIFFYMHKDIFDELLETEKNAQPLSMEVGRSVRQPL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 122)

MAHLKIHGLVQIRSTNRSKHTRASQWK---------EAVIEIVERKQKVNLVV
SFKLEERRRV-FQLGDNVTGVVVS-GELGLYHLDLTLRDDTSLLIDKLSSADVEHLKSFL
D

ENSGT00440000033542_0_Linker_0_1 (122, 430)

SSTPCESQQP-MESMSNQDTLEIS----D------------------------------
PFFRENQDVVCVSLNTALESGTLL---------------------SRKMPLC--MSNTTG
SHTEKKRGEKQGRKRKTEPSPSTVEVTTKDI-LKEN-NPEQKK--KSRRYYSRNRGGKAE
KAVAL---REQEKRNNWKLEPAFSSKV-----------YGKSTLDG-----TVLP-IATC
SDDRD-----LSI---------------------FGLE----------IITHNGIQPPPD
NYLKQLKRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWEKVSYDDL-IMP
L-SQLLVLKDIRDIEIKGELLTSVKKSISTV-ADTFSGNEQN-DAHEFLSLCLDQLKL-N
MEKVNAMWDTERKNE-----------PTCAG-AKRFVCPVGA-NFEFELHS-SIICEGCG
EAT-LKTEVSNYLS-IDLHHGT-KTHPL-SIQ-KSFDLFFTPEKI------------EHN
CEKCK-NKNSVLKYTLRRLPRVLIVHLKRYQVT-TDLLPVKSEQPVEISQYLNISSHCHE
NRKLPFPLINTPPKGD-YDIPNVSPGLMPEIFSQSMSSK----K-------VISESSD-P
LVLQVGSSVDAEIQ--------SFQIMYEDE--SEEEQQRGLESGS---MLDP----ELL
KTENRVFRQKISPAPDSMMGDGYSFLPMLCE----PMSI---QDPGLAE-MG-----LQE
VPENPEFKY-------YG--KPDGRTNSELSK----------------------L--HQN
H-----GGRIKGSYLPASF-ANM------RSSLE--DPEKDLSRSS---EFEEDDPHS--
-------------------------F-----------------ALG-------SDESKDE
EMGDNLHNYRLVSVVSHFGSSPNSGH-YVSDVYDFQ----RQAWLLYSDVQV-------F
ENPDPSSQ-ENRLHTG---YIFFYMHNEIFEELLKKASECKVLSTSKEEKRDID-YFSTL
LNGLTYILEEF-------------------------------------------------
--------------------

------MSS

PF16674 // ENSGT00440000033542_0_Domain_0 (10, 125)

ATTVHGYVQIWNM----KTGMSKST---------AAFIEPVEGKKKVKLML
YFNTGQ-VKT-FQLSDNIKSVAFRAYGQNENHLHLTFQNNDFLFVERLSSTHARELKTLL
DRVH

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QIGGQPP-MKPGKEDGVFTST----TIQKGIS-KT---------------------
SSHKVYKTSSSGHLEVAKERTSYI---------------------QKKMSLF--AEK-S-
SFIRKGLFAHHFGKRKRILASDL-E-MNKSEKLMKE-NYFKRS--TYKINPWKYVSHTWE
KQLKE---RELRERKKLPFESSFVTSF-----------LGNPYLDV------TI--PHII
TEKVFVPFFWETS---------------------YGEY----------IPEWDVLEKSVT
FFPEKV-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYMNAVLQSL-CSIPSF-VNDLLNQGFPWGKIPHDAL-SLC
L-AQLLVLKDIYNIATKVKLLVSIKKAISLV-ADIFSGDVQN-DAHEFLSLCLDQMKE-T
MQRLSLMWKTKMELEEDSPEKLL--FAY-SP-TKMIVCPVIT-NFEFEILR-SIFCKSCG
RAV-LKTEPNNYLS-INLPQGT-KADPL-SIQ-STFDLFFDAEEL------------EYK
CEQCN-HYRSIAVQKFSRLPRVLIVHLKRYRLN-EYWSLRKDEQEVIIPTYLKLSSHCNE
NTKPPLPLSENAHIKD-FHLLKIFQNMSFGILNLTMPET----K-------LTSKSKD-S
LPLHIGSNKKSVPQ--------KFQRFLKGA--GREQQQKDLEKNSKLNIMKS----ELA
SSGNVTLTGQQLSA-GSMNYVKDTSLSPICKDGDKPSLD-----TSLTE-AH-----SQE
VSENTEIKKHEEIN-GFV--ELDFSSFSETTEDLYEDKNPSIPG--IFQNVARQT--QQC
D-----SVRIHKQALEQALPQSL----PKLNAQE--HT-QNF-RPT---ELNVQKPDV--
-------------------------NSLCSVDANRNPEDKDILDKTESKAKEPKEPKRSA
DKRDR-HTYRLIGVISHIGSTTHSGH-YITDAYDFK----RHLWFTYNDLQI-------S
SIQEVQVQ-KSRLCTG---YIFFYMHDEIFEELLTRGESSQSCSTKARKTPQAQ------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLSNPGRGSIKTAAGSGITV---------------------TRTIPP----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGGRAGSKDYSSGSTNLD------RTNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKAEPVPGEENLP-------DVSV-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVVIPRYLTLSSHCTE
STKAPFTLGWSAHTAV-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEIPGSEQQQ--EDLEKDSKSCRIEPGK-SELE
NSGFDGMSEEELLAAVLEISKRESSPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDPVETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFNELLETEKSAQALGVDAGRAARQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIAEKENKISLIV
HYNTGGIPRI-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKPSQGSGSFGVILGSRTSQKETN-RQLSYSDNQTSSKRGSLETKDDM
PLRKVLGNPGRGSIKTVAGNGIAV---------------------TRTVPS----LTATS
TPLRSGLLENRTEKRKRMLSSGS-E-LSEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSGVTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPFPGEEISP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWNAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCDMSCNEQQQ--EVLEKDSKLCRIEPDK-SELE
NSGFDRMSEEELLAAVLEISKTETSPSLSHEDDEKPTSS---PDTGFAE-DD-----IQE
MPENPDTMESEKPK-TVT--EPDPASFTEIAKDCDENKENKTPE--VSQ-EVDWL--QQY
DM----DREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSIEAGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKEAEEMRSFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHSA-MKP-QGSGSFGAILGSRTSQKETN-RQLSYSDNQASSKRGSLENKDDV
PFRKVLGTPGRGSIKTVAGNGI-----------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--AMTDPARKYLISSRE
KQLSL---KQTEENRTSGLLPLQSSSFYGSRVGSKDYSSGASNLDR-------TVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YTGWNKPRMPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTESIPGEENSS-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTTSK----K-------FTFKSKN-S
LALCLDSDSEDE-LKRCVA---LSQRLCEMSGSEPQQ--EDLEKDSKLCRIEPDK-SELE
NSGFDRMSEEELLAAVLEISKREASPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENLDTIETEKPK-TVT--DPDPASFPEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDIFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSVEVGKTARQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSSLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-VKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGANLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPISGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLCRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPTEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKSK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 122)

MAHLKINGLVQIRSTNRSKHTRASQWK---------EAVIEIVERKQKVNLVV
SFKLEERRRV-FQLGDNVTGVVVS-GELGLYHLDLTLRDDTSLLIDKLSSADVEHLKSFL
D

ENSGT00440000033542_0_Linker_0_1 (122, 430)

SSTPCESQQP-MEPMSSQDDLESS----D------------------------------
PFCGEHQEAACGSLNTTPESGTPL---------------------SRKMPLS--MSNTTG
G---QKRGEKQGRKRKTEPSSSSAEV-NKDI-PKEN-TPDQKK--KSRRYYSRNRGGKAE
KAVTL---REQEKRSNWKLEPAFNSKS-----------YGRANLDG-----TILP-IATC
SDDRD-----VSI---------------------FGLE----------IITHNGVQSLPD
PYLNQLKRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWEKVSYDDL-IMP
L-SQLLVLKDIRDVEIKGELLTSVKKSISTV-ADTFSGNEQN-DAHEFLSLCLDQLKL-N
MEKVNAMWDTERRNTC----------AGSAG-TKRFVCPVGA-NFEFELHS-SIICEGCG
EAT-IKTEVSNYLS-IDLHHGT-KTHPL-SIQ-KSFDLFFTPEKI------------EHN
CEKCK-NKNSVLKYTLRRLPRVLIVHLKRYQVT-TDLLPVKSEQPVEISKYLNISSHCHE
NRKLPFPLANTS--------PDVSQGMMPGIFNQSMLSK----K-------VISESCD-P
MVLQVGSSVDAEIQ--------SFQIMYEDEDASEEQQQRGLESGS---MLEP----ELV
KTENRILRQKTSLATDSMMGDGYSFLPMLCE----PLSI---QDPGLAE-MG-----LQE
VPENPEFKNYEKIN-IYG--KSDGRTNTELSK----------------------L--YQN
H-----GSRIKGLFLPASL-ASV-------SSQE--DPEKDLSRSP---ELQEDDPHS--
-------------------------F-----------------AFG-------SDDSKDG
EMGDDLQNYRLVSVVSHFGSSPNSGH-YVSDVYDFQ----KQAWLLYSDVQV-------F
ESSDPSIQ-ENRLNSG---YIFFYMHNEIFEELLKKASECKVLSTSKEEKRDID-YFSTL
LNGLTYILEEF-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MSSIMVHGYAQIWNK----RTGMSQPQ---------EVFIETVQGRKYFKLLI
YLKTGR-VRT-LKLNNNIKHVALQPYGVNLSSIHVTFQNDGFLFVEKLSSTDAEHLKAFL
DRVH

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QSSSEPH-MSSDKGGV--AST----STGTQTS-EI---------------------
LLPKDSETSGEGCSGTDKEQETSV---------------------HQKKSLL--TSKSS-
RLTDED-SENRYRKKKKMSPSDP-E-VNENEKSLTK-KN-IRE--KSKANPLKYKSYSWK
KEIKA---EEFKNSKKLA--SLLVASY-----------FKKTYVDG------TT--LQFL
TENTLEQFLLAIK---------------------RSER---------G----TESELSRR
FYHSAV-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYINAVLQSL-CSIPFF-ANDVLNLGFPWGGISHNLF-CLC
V-ALLLTMKDVFNVKIKEKLLVVIKRAISVI-SEMFPEESQN-DAHEFLSFCLQQMKE-T
LQKSNVVLDSENEFQEENSSQQA--FAGVSA-ARGADCPVVT-NFECELLR-SIFCKACG
QAI-YKIEPSIYLS-INLPQGM-RARPL-SIQ-STFDHFFAAEEL------------EYR
CENCA-YKKSVVVHSFSRLPRVLIIHLKRYRFD-KFFQLSKDDQAVIVSKYLDLSSHCKE
DTEPPVPLRKDAHIRD-LRLLKAFQKLSLKIILSLSSVKKSKSK-------YKSKSKY-R
IARRVKSVKKPEPQ--------KSQQFLKGK--RRVCVQENPRKVHKADTRES----ESA
CFRDGASIGTKQLA-TSVMNLEDTSLPLFYRNADKPSGR---PDTCLTE-AQ-----LPG
VPEDPKLRKSKKKN-TFA--ESDFDSFSETTEEFSKNKRARIPE--RSQEVAEQS--EHC
D-----RLEVHEEAPQQILHEGL----PKPDAQE--HS-LNLRGCT---ELSPQKA----
-----------------------------------NPGNKDILGKK-TES-ETQEPGKKA
NEKNP-YTYRLIGIISHIGNTPDSGH-YISDAYNFK----KQVWSTYNDLLV-------S
RISESLVQ-KYRLCTG---YIFFYMHNEIFEELLQKFKTTQSPSQFPSQSPSPPPPPSQS
PARSQSLSLSP--------------S-KKSQSKTPPPPVSVSGPVSVSVSVSV-------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MAPLKINGFVQIRSKNRSKHTRASQWK---------EAVIQIVERKQKVNLVV
SLKLEGRSRV-FQLGDNVAGVMVSCCETGEHHLHLTLKDDTSLLIDKLSSVDVERLKSLL
DSF

ENSGT00440000033542_0_Linker_0_1 (124, 430)

HPCESQQL-EEPKSSQHVLESS----D------------------------------
PFCRKHQESVAGSQNTKQESGAPG---------------------PMKMPLL--WPNSSS
SHVEKEKVEKPSIKRKRKSTPSV-E-IIEEI-LEVN-NPEPEK--KSKTYNSRNKRCKGE
KPMAL---RDQEKLNIWKLEPSFNTNT-----------CWRPNLDD-----TILPTL--A
WSDES-----GSK---------------------FSQE----------TQ-TYDLQPPLE
TYAKQLKRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSL-FGITSL-AKNLLTQSIPWEKVSYDDL-IKP
L-SQLLVLKDIRDIEVKGELLINVKKSISTV-ADTFLGDEQN-DAHEFLSQCLDQLKL-N
MEKLNTMWLTEMDNDN-------------AI-PKRFVCPVSA-NFEIELQS-SIVCEACG
EAT-LNTEVSNYLS-VDLHQGT-REQPL-SIQ-KSLDLFFTPEKI------------ERN
CAKCK-NKNSVLKYTLKRLPRVLIVHLKRYHLT-PNGLLVKSQQPVEISKYLNVSSHFNE
NIKEPLSLTSKTSYED--------CDMMPEILSQPIPS----------------------
------------------------------------------------------------
------------------------------------------------------------
----RSVKNYEKIN-VYG--TADRHTTTEMFNYFYDLKEQMILE--GSQEMAEQL--LQN
P-----GTRFHKEFLPQGSPQSV------RDFAE--DTEKDMNTSL---DLRDDIDD---
-----------------------------------------------------EYSLESM
VFGDDPQNYRLVSVVSHFGSSQDSGH-YVSDVYDFQ----KQAWLLYSDVQV-------F
EIPEALIQ-ENRLHTG---YIFFYMRNELFEWLLKKASECKLLNTPKEQQKNMD-LFSTL
LNGFTYFLEES-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MISLKVRGFIQIWSQ----RTGMTKLK---------EALIETVQRKKEIKLVV
TFKSGKFIRI-FQLSNNIRSVVLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFL
DIIHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NKFQQP-VKPDDDWSVFESR----NVLKEID-KT---------------------
SFYRICNK--------------PS---------------------YQKMPLF--MSKSP-
THVKKGLLENQGGKEKNPLASGL-Q-MNEDI-LKEH-NPVPNK--KYKTDSLKYIQSNRK
NPSSL---EDLEKASDLKLGPSFKTNS-----------NGHPNLDE-----TVL-ATQTL
DAKNGLTFPLEPA---------------------HSQD----------DPRCNEAQVPLD
SHSEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNAILQSL-FAIPSF-ADDLLTQDVPWEYIPFEAL-IMT
L-TQLLALKDFCSTEIKRELLGNVKKVISAV-AEIFSGNMQN-DAHEFLGQCLDQLKE-D
MENLNAILNTGKKCGDENSSPQM--HVGSAA-TKVFVCPVVA-NFEFELQL-SIVCKACG
HAV-LKVEPNNYLS-INLHQET-KPLPL-SIQ-NSLDLFFREEEL------------EYN
CEMCK-HKSCVARHTFSRLSRVLIVHLKRYSFN-NAWLLVKNNEQVYIPKYLSLSSYCNE
STKPPLPLSSNAPVGK-CEVLEVSQEMISEITSPLTPSM----K-------LTSESSD-S
LVLPVEPEKNADLQ--------RSQRDCGEE--SQEQHQGDLENGS---ALES----ELV
HFRDRAISEQELPVADSLMDQEDISLPVICEDGGKPISS---PDTRLVE-VH-----LQE
VPQHPELQKYEKTN-TFV--EFDFDSVMESTNGFYECKENRIPE--GSQGMTEQF--QQC
F-----EESIIEEFLQQAPPPGV----RKLDAQE--HAEETPSQST---ELRLQQADL--
-------------------------NHLEALGCD-NPGNKNILDTENTRG-EAKELTRNV
KMGDPLQAYRLISVVSHIGSSPNSGH-YISDVYDFQ----KQAWFTYNDLRV-------S
EISETKMQ-EARLHSG---YIFFYMHNGIFEELLRKAENSRLLNDDSLYRAA--------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 125)

MSAIMIRGYAQIWNK----RTGMSKAQ---------GALIETVEGKKNFKLLI
YFKCGK-VRT-FYLNNNIKSVAITSYGENLNHLHLTFQNNNFLFVERLTSADAEQLKMFL
DKVP

ENSGT00440000033542_0_Linker_0_1 (125, 429)

QSSPEPH-MNPKRVS---MST----RTAMQTK-QT---------------------
SLSSVYLESGEQCSGTDKEGGTSV---------------------PQNTTLL--SSKVS-
L-TSKE-SE--TQHRKKMQFSDS-E-VKKSEKHLIK-KSSIRK--RFRANPLKYKNRSWN
KLSRT---EVLKKSKKLT--RASTARS-----------FDSRPLGD------TG--LQYL
PEKTLEQLLQALN---------------------RSEG---------G----QVPKSLSK
AHSQSV-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYINAVIQSL-CSIPLF-VNDVLNQGFPWGRISHDIF-CLC
V-ALLLVMKDVFNMKIKAKLLVNIQKAISLV-AEIFAVDTQN-DAHEFLSFCLQQMKE-G
LQRSNVVCITENKPEQENLPQQV--FAGDSA-AKVPDCPVMT-NFESELLR-SIFCKACG
QAV-YKREPSNYLS-ISLPQGK-KACPL-SIQ-STLDQFFITEEL------------EYK
CEKCK-HKKADAVHKFSRLPRVLIIHLKRYYFN-EYFLVKKNDQAVTISTYLDLSPHCNE
GTKPPVPLSKNAHIRD-VQLLKTFQKLSFRILCSLSLVTLE-------------SFKD-S
TAKGVKSGKEPASR--------KPQRVLRGK--KRVQPQKDLGKVCKLDMKES----KSV
HVGDGALIGKEQLA-SSAMNLGDTSLPLLHKLAPQPVSS---PDTCLTE-AQ-----FPE
IPENVEVKKSQKTS-TSA--ESDFDGVSETTEDFSKDNKTRVRE--RSQKVAKQS--EES
D-----GTRTHKDAPQRTLPESL----LKLGNLQ--PR-VSLTRCT---ELILQEA----
-----------------------------------SRRSKDSSDKK-TES-KTQEPEKKA
DEKSP-CTYRLIGIISHIGRSPGSGH-YISDAYDFK----NQVWFTYNDLVV-------S
SVSESVVQ-DSRLDTG---YIFFYMHNEIFEELLLRV-----------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHGA-MKPSQGSGSFGAILGSRTSQKEIS-RQLSYSDNQAPAKRGSLETKDDI
PFRKVLGSPGRGSIKAVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRVLSAGP-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEYSPGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKHSVA---LSQRLCEMSGSDQQQ--EDLEKDSKLCRIEPDK-SELE
NSRFDRMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQTLSMEVGKTTRQAL-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIA-----------------------RTIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRAYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDLKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPR-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAS-----
------------------------------------------------------------
--------------------

-------MTSLLVPGFVQIWSK----KTGMTKSK---------EAFIEIVEGKKKDKLVI
HFSAEEVIKA-FQLTNNIRNIVFRFFGGNQNHFHVTFQNNSFLFIDRLSYSDAEQLKMFL
DK-HQNKFQPS-MELVRDGGIFSGA----ITQKEIE--T---------------------
TFHSVSKKTHTGSLETAKGSAAAI---------------------LQNLPSF--TSISS-
THSLTGLLESGHKKSKRK-SSRP-E-SNEDF-LKKD-NSVLDK--KSIAYPLRYISHTQE
KPVDL---KGLKDKRKVKFGTSFETRP-----------TGNCHLHS-----VRF--MKAL
SRKSLLTFLFEPK---------------------YNHD---------GLEEWEEHELSFD
FFPD

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KQ-LQGFP--NLGNTCYMNAVLQTL-FSIPSF-GDDLLYQSIPWGKVPFSGL-ILC
L-AQLLVLRNLYNIRVKEKLLLNIKRAIAAV-AKIFSENIQN-DAHEFLGHCLDQMKE-N
MKTLQAVWESKCEFEKRNSPQQA--FADSAA-SKVLICPVTT-NFEFELKC-SITCKACG
QVV-LKREPSNYLS-INLPQGA-KGVPM-SLQ-SSLDLFFEAEEL------------EYR
CGKCE-HERSLATHIFSRLPRVLIVHLKRYGFS-GSLPLGKNEQNVIVPTYLNLSSHCNE
STKPPLPLGSYVYTEN-SQAEKVFEKMNSGTISPVMPST----K-------LASESKD-P
LTLCLGSDKEAETQ--------KCQGVFKGL--SREQQDKNPGKDSKLNITES----ELV
SSRLRAVSEKELLARASVTYEEDLSLSLIRKDGNKTISS---LGAGLSQ-VH-----FQR
VSENPELTKYKKPN-MFS--ELDSD-------------CARIPE--GFQKVVVQP--GSC
D-----GVKLCGHFSEQAWSPSP----QKP-AQG--HT-DNLRRHT---ELSLQEAKV--
-------------------------KLLGALGSCKNSGNTDILDRKNKEA-EAEEQ-EKA
QKIDP-HAYRLISIISHLGSSLHSGH-YVSHIYDFE----RQLWFTFSDLQV-------T
IMKETQRKGGERLSTG---YIFFYMHNEIFEELSRREENSELHSTNAGENCQEG------
------------------------------------------------------------
--------------------

-------MAPPTIRGFARTWSK----GTGMTNLK---------EALIQMVEGEKESRLVV
IFNSGRSTRV-FQLSNNTTSMVLRHSREEQSSLHLTFQKNCSLFIDKLSCGDAEKLKKFL
DRVHQKTSQLP-MKSRCEWVILGGG----KTQEKSN-KI---------------------
PFHKVGDKPSNESFSLENGSGTSV---------------------LQEMPLL--MSKSS-
TLVRTGLLENPCGKRKRMPSSDV-K-MHEDF-LKEN-NPVLNK--KSKTDPLKCISNNRK
EPLSL---ENLEKCNKSELGPLFNASS-----------TGNPNLDG-----NSF-STHHL
SVERSLAFPSEPN---------------------CSQN----------EPGQKESQMPSN
SHLQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QK-RQGFP--NLGNTCYMNAILQSL-FAIPSF-ADDLLNQGIPWEKIPLDAL-IMC
F-SQLLVLKDLCDIEIKGELLVNIKNSISSV-AAIFSDDMQN-DAHEFLSQCLDQMKE-D
MEKLNAY-MTERETGEEISHPQI--SAANAS-TKVFVCPVVT-NFAFELQC-SIICKACG
EVV-CKTELSNYLS-INLSEAK-QSLPS-SIQ-YSFDLFFRAEEI------------EYK
CEKCK-HKCSVAMHKFTRLPRVLIVHLKRYIFN-DCRVLVKDNQQVGIPIYLSLSPHCDE
NTKPPLPFSSNAHIED-SQVLKVSQEMISGTTSSWMSPM----T-------STSTSKD-F
LVPHIEPDKDTEPQ--------KCQRLSEGS--SQEQQHRDPENDSKLNITES----ELV
NSRDSTASEKEWPAADSMIYWEDTSLSVICELGGKFTSS---PVAGLVQ-AH-----HQE
VPESPEPKTHQTTN-ASV--KIESNSITQSTEDFYENKENRSPE--ESQGVVKQL--QQC
D-----GKRIYEKVLQQALPQNL----RKPDAQE--HTEEDLSRST---ELSLLKDSL--
-------------------------NSLRALGSGENPGNKGVLGMENTEA-EAEEQKRNT
TIWDPHHAYRLISVVSHLGDSPNSGH-YVSDVYDFA----KQAWFMYDDLKA-------L
QIQEANMQ-NDRSCNG---YIFFYMHTDIFEELLRKAETSQSQSTESLAMFLHGE-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MTSLKIPGFIQIWSK----RTGMSKLK---------EAFIETVEGKKRTKLVV
IFKSREFIRVFFQLSNNIRSVVLRHRKGRKSSLHLTLQNNIFLLIDKLSIRDAEQLKMFL
DVVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NKFQQP-MKTDDDWNVFGSR----KAQKEIG-KT---------------------
SLYDTCRD------------KTSC---------------------SQKIPVF--MSKST-
RWVIKGLLKNRDGKRKK--SSGL-E-MTENF-QKKH-NPVISK--KSRADFLKYVRSNRK
ESSSL---KDLGKNRNSKLVPSLKTNC-----------NGNPNLDG-----TVS--TQTS
STKRDLAFPLDPK---------------------HSQS----------DPRQNEAQVPLD
PHPDQL-WE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNAILQSL-FAIPSF-ADDLFMQDVPWEKIPFDVL-IMP
L-SQLLALKDICNMETKEELLVNVKKAISAV-AGIFSGNTQN-DAHEFLSQCLDQLKE-D
VKELNANLKTEREADDKNVSPQT--YAGNAA-TEVVVCPVAT-NFEFELHL-SIICKACG
QAV-LKSELSNCLS-INLHQET-KPFPL-SIQ-NFVDLFFRAEEL------------EYS
CKTCE-HKSSMAKHKFSRLPRVLIVHLKRYRFN-DACLLVKNSQNVYIPKYLRLSSHCNG
STKLPLPLSGSAASWH-SKVLGVSQQMTSEIISPLTLSM----R-------LTSESSD-S
SVLYAEPKKDGDLQ------------TCEAA--DQEQQQKDLESGA---KLKS----KLV
NFRDGTASERELPGTGWMMDQRDTFLSMIHEDGRKPISS---PNTGLIE-VH-----LQE
APENLELQDYEKTK-TFV--ELDFDSVTESTNGFYECKGNGIPD--ESQGMVEQL--QQC
I-----GKSTKEEFLQHAPLPNA---------LD--PTEKALGRSR---EFKLQKADL--
-------------------------SSLRAWGSDENSGNQDLFDLENTRT-EAKEPKRNV
KTEYTLPNYRLISVVSHIGSSQDSGH-YISDAYDFQ----KKAWFTYDDLRV-------S
EIQETTMK-KARQCSG---YIFFYMHNETFEALEDK----------TGADPQGDYEDDFL
H-RPA-------------------------------------------------------
--------------------

-------MAAIIAHGFVQIWNM----DTGMSKLK---------EAFIETVERKKKARLVI
RFSTGE-YTT-FQLGNNIKNIVFRSYGENQNYLHLTFQNTSFLFIRKLSSRDAKNLTMFL
DRVHQNNLQSP-FRTDMGGSVFSRT----KTQKKIN-KT---------------------
LFDKIYQKLVSGFFELREGSGTPD---------------------LQKLLLD--TSKLS-
LLTFNELLKEGSRKRKRMASSDS-D-ICGKS-QEEN-KSVRNK--KSKTNPLKYVTDDEK
EEMWL---KELKESKKLDY--LFETNP-----------TGNPYLDG-----TYF--LQTL
AEKIYMILLLKSL---------------------CSED----------DPEWEKLKMTFD
FYPE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KL-CQGLP--NLGNTCYMNAVLQSL-FSIPPF-AYDLLYQGSPWSEIPLDAL-SLC
L-SHLLVLKDIYSVKTKERLLINIKNAISTV-AEMFSDNTQN-DAHEFLGHCLDQMKG-N
MEKLNTIWKTKIESEEENSPQQF--FADNDV-TKRLVCPVTT-NFEVELLH-SITCKACG
QVV-LKTEVNNYLS-INLPQGK-KTHPL-SIQ-STFDLFFGAEEL------------EYK
CGKCN-HKTSVSMHKFSRLPRVLIIHLKRYSFN-KFWSLRKDDQEVIISKYLKVSSHCTE
STKPPFPLNKNVHIRD-FHLLKFFHNINFEILKSLTPST----K-------LTSKSKD-C
LAPHIESDKESEPQ--------KDQIF--GL--SKEQKQNNLGKHSKLTTAES----LLV
NSGYGTAIEKELLVPGLMRNLENTNLSVVHEDEGKPTSG---PDTS-AE-VH-----LQE
VPRNPKRKKYEKSS-MFA----AVDSVTETTEDFSEDEKNKISE--EFSNVPGQT--PQC
E-----KLKIYEEALWQALLQSL----PKTDAQC--HT-DNLTRPT---ELSLQEANE--
-------------------------NSHGASSSNKNLGHKDFLAKKMTEA-KAKKP--NP
KIRDH-YAYRLIGVISHLGNTLHSGH-YISDAYDFE----RKVWFNYNDMQV-------S
SIQEDLMQ-EARLRTG---YIFFYMHNKIFEELLGREENSQPHSTKAGENHQKE------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGTFEIVEKENKINLVV
HYNTGGIPRL-FQLNHNIKNVVLRPXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXX
XXXXXXXXXXXXXMKPQGSGSFGAILGSRTSQKETN-RQISYSDNQASSKRSSLDTKDDA
SFRKVLGSPSRGSIKTTAGSGLPA---------------------TRTIPS----LMTTS
TPLRSGLLENRSEKRKRMMSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRASGLLPLQSSSFYGSRAGSKDYSSGSTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRFNQD----------YTGWNKPRVPLT
SHPQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-L-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVPGEDNSP-------DIST-PRAFTCPVIT-NLEFEVQH-SIICKAXX
XXX-XXXXXXXXXX-XXXXXXX-XXXXXXXXX-XXXXXXXXXXXX------------XXX
XXXXX-XXXXXXXXXXXXXXXVLILHLKRYSFNVALSVNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAV-SRPLKASQMVNSCNTSPSTPSX----XXXXXXXXXXXXXXXXX
X----------X-XXXXXX---XXXXXXXXXXXXNEQ--QDLEKDSKLSRLEPYK-AELE
NSGFEEMSEEELVAAVLEISKRDSSPTLSHEDYEKPTSS---PDTGFAE-DD-----IQD
MPENPEPVETEKPK-LIT--EADPAIFTEMTKHCDEKKKHPTPE--GPQGEVEWL--QQY
HM----EXXXXXXXXXXXXXXXX----XXX-EAWEQREDDDIKRAT---ELSLQEFNS--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------A
KVQETSVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQPLPAEAGKPAQQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMKLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHTA-MKP-QGSGSFGAVLGSRVSQKETN-RQLSYSDNQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTVSGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRML-SGS-E-LNEDY-PKENDSSSNNK--TMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKDYSSSVTNLDR------NNVSSQTP
SAKRSLGFLPQPIP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQHQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEAIPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHTTI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCTDSDSEDE-LKRSVA---VSQRLCEMSGNEQQQ--EDLEKDSKLSRAESE------
KSEFDRISEEELLAAVLEISKRETSPTLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MSENPGTVEAEKPR-TVT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DI----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQTWFTYNDLEV-------S
KIQETAVQ-TDRDRSG---YIFFYMHKEIFDELLETEKNSQAFSMEVGKTARPAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHXXXXXXXM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRT-FQLSHNIKNVVLRPSGVKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHTGKVMQSLKLA----------------------VLKTVSSKRGSLETKDDT
PFRKVLGNPGRGSIKTVAGSGITV---------------------TRTIPS----LTATS
TPLRSGLLENRTEKRKRMLSSDT-K-LL--------------------------------
--------------CFLGLLPLQSSSFYGSRAGSKDYSSSVNNLDR-----YVGVISYRV
LYYLASLMISIPSV-------------ISKTPLYCFFV----------VCFWYQG-----
-------LNSQS--CTCQACLIKMIKSA------YF-IKEYLRKNIFISKIM--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSSLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-VKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRIISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGANLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPISGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPTEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

PF00443 // ENSGT00440000033542_0_Domain_5 (1105, 1164)

GH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTSQQEEYLKDFN----YN
---FKLLELTYVCFVI--------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEVVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLNAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLETKDDT
PFRKVLGNPSRGSIKAAAGNGVTP---------------------TRTIPP----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLASSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTATKDYTPGSTNLD------RTNISSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKIEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKVCG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFNLGWSAQMAV-SRPLKASQMVNSCITSPSTPSK----N-------FSFKSKT-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGSEQQQ--EELEKDSKSCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDSVETEKLK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALNLEVGKTTRQVS-----
------------------------------------------------------------
--------------------

-------MAAVIVRGLVRIGSK----KTKVSKVR---------EACIEIVERERNVILVV
YFNTGA-YAS-FQLSNNIEDIDLRPSGEDQNYLHLRLQTNDLLIIEKLSSGDAENLKKFL
DRVHP---QPP-VRPDRDGSIFAST----TTQKAGG-KT---------------------
ASHKIRRTSSSQSFEKERN-ETPD---------------------DKEMPLC--ASELP-
TFTCEELLEKEYGKRR--PSSGS-E-MNKIF-LQED-TCSEGT--VSKMYPLRYVSLKQ-
RELIL---KGLKQNKEFELGPSFKIDF-----------SGKHYLDV-----SDL--LQRV
SEKIYLAFLSELK---------------------YGED----------DPEWGKLQMIFD
FYSE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KL-YQGFP--NLGNTCYMNAVLQSL-LSIPSF-ANDLLNQDFLQGETPLDAL-SIR
L-VQLLVLKDIYNIKIKEKLLVNFKNTISAV-AEIFSDNAQN-DAYEFLGHCLDQIKQ-N
MRKLNTIRKIKIESEEGNSPQQV--SAGSAD-TKVLVCPVAS-NFDFELLR-STSCKSCG
QIV-LKAEANNSLS-VSLPQRE-KARPL-SIQ-SSFDLFFEAEEL------------EYK
CETCK-HRSSVAVHKFSRLPRVLIVHLKRYKFS-ESGSLRKDDQKVIISKYLKLSSHCNE
TTKPPLPLSKNAPLTD-FQVLELFKKMNSEAISSSTAST----K-------QTSESKD-S
LTPHIRSEKESEPQ--------TCQTLHKAS--SFKQEQGDLGEDSKLNIIES----TLV
NLRHRAAIARELLAVGLMRNLEDSSLS----LKGTPTSS---PDTY------------HK
VAKSRKGNKYKRTN-ISA----DFESMPETTEEFCKGKKPRISE--ESYQVPEET--QQC
G-----GIRLFEQDLGILLIRSL----SGPDAQW--HT-DKC-RPT---QLNFQGTKV--
-------------------------SSRGVLGSNKYSGRKGSSDVAKTKS-SARKPKIEA
EMRES-HDYRLIGIISHIGKTPNTGH-YVSDAYNFD----RQVWFSYSDLNV-------S
STQETPVQ-EARLQTG---YVFFYMHNEIFEELLGKKENSQPHSTKEAETQK--------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVDKDSKVSLVV
HYNTGGIPRV-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKSSQGSGSFGTILGSRTSQKETN-RQLSYSDNQASSKRGSLETKDEI
PFRKVLGNPGRGPIKTVTGSGMAV---------------------TRTIPS----LTLTS
TPLRTGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLSSSRE
KQLSL---KQAEENRTPGLLPLQSSSFYGSRTGSKDYSSGGTNLDR------CNISNQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YTGWNKPRAPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVLGEENSP-------DTSA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFIRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLRACQMVNSCITSPSAPSK----K-------FTFKSKS-S
LTSCLDSDSEDE-LKRSVA---LSQRLCDLPGNEQYQ--EDVEKDLKLCRLDPGK-SELE
NSGFDRMSEEEVLAAVLEISRREASPVLSPEDDDKPTSS---PDTGFAE-DD-----IPE
MPENPDAMEIEKPK-AIT--EPGPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DI----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKTSQALSMEVGRAARQAS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPIKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSAS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLTL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMSGNEQQQ--EDLEKDSKLCPIEPDR-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEIDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGTEDVFDMEYTEA-EAEELKRNA
ETGSLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTRQAS-----
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------

PF00443 // ENSGT00440000033542_0_Domain_5 (1105, 1164)

GH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIFEALVSKAEKSQLTRSCKVELQAYMSNAVND
---MSFIIKHY-------------------------------------------------
--------------------

-------MTLLKLCGSIRMHSM----QTGTTKWK---------EGTFEIVDKDSKVTLVI
HYNAGGIPKM-FQLNRNIKKVVVQPNKGKLCRLMITLKDSSFLMVDKIPLKDAEEMKLFL
EGVQ-NGTHAA-VKIPLGSGSFVGVLGNRGTQKDSY-RQFPYTENQKR----------GN
VESKVLSSPGRTSVKITPVPGMSG---------------------NRFNGSTSP---ATS
TPHRTGLLENRER--RKRAPTTP-E-MNEDY-PKENDSSTNNK--AMTDPTRKFLHSCRE
KQLNL---KQAEENRASGLLPLQSSSFYGSRS-SKDYSAGNSNLDR------SNVLNQTP
SAKRTLGFLSQPAP-------------LSVKKMRSNQD----------YMGWNKSRVPLS
THPQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFA--NLGNTCYMNAILQSL-FSIQSL-ANDLLKQNIPWKKVPCNAL-I-R
RFSVLLAKKDVCSFEAKKELLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPSSGEDSSV--GRISDDLSA-TRVYTCPIIT-NLEFEVQH-SIICKMCG
ETV-TKREQFNDLS-IDLPRRK-KLLPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSALVTHKFSRLPRVLILHLKRYSYNVALSLNHKVGQQVVIPRFLTLQSHCTE
STRPPLNLGWSAQSTI-SRPLKVSQMVNSCSVSPSTPSR----K-------YTFKFKG-P
VVSTMDSDSEEEPLKRPVT---NSPKQCDK-----EQQRDDLEKSSKRVRTESEKASEST
NAGFDGMNEDELLAAVLEMSKKETSLSLSH-DEDKPTNS---PDTGFGD-EE-----LQD
LPDNTEPMDVEKPR-VSA--ESGFATFTEITKDFDENKENKTPE--GAQGDIDWL--QQY
DL----EREREEQELQQALAQSL----QEQQEAREQKEDDDLKRAT---ELSLQEFNN--
-------------------------SLLDSLASDEDSGNEDFLDMEYSEA-EAEELKRNA
ETGELPNSYRLTSVVSHIGDTSSSGH-YISDVYDIR----KQAWFTCNDLAV-------S
RIQEASVQ-SDRDRSG---YIFFYMHKDIFDELLEVEKNTPCVTAPAKSVVS--------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLHAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASSKRGSLDTRDDT
PFRKVLGNPARGSIKTAAGSGIPV---------------------SRTIPS----LTSTS
TPLRSGLLENXXXXXXXXXXXXX-X-XXXXX-XXXXXXXXNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSRDFSSGSTNLDR------TNISSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRMPLS
SHP-

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSLQSF-XXXXXXXXXXXXXXXXXXX-X-X
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXX--XXXXXXXXXXXX----
XXXXXXXXXXXXXXXX-----------XXXX-XXXXXXXXXX-XXXXXXXX-XXXXXXXX
XXX-XXX--XXXXX-XXXXX----XXX---XX--XXXXXXXXXXX------------XXX
XXXXX-XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALYLDSDSEDE-LKRSVA---FSQRLCEMSGSELQQ--EDLEK----------------
-------------------SKRDISLSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENLESVETEKPK-AIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDIKRAT---ELSLQEFNN--
-------------------------SFLDALGSDEDSGNEDVLDMEYTES-EAEELKRNA
ETGTLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASGQ-SDRDRSG---Y-FFYMHKEIFDELLETEKNSQALSMEAGKTTRQTS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MASLFLRGFVQIGNC----KTGISKSK---------EAFIEAVERKKEDRLVL
YFKSGK-YIT-FRLSDNIQNVVLKSYRGNQNHLHLTLQNNNVLFIEGLSSTDAEQLKIFL
DRVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NEVQPP-VRPGKGGSVFSST----TTQKEIN-KT---------------------
SFHKVDEKSSSKSFEIAKGS-GTG--------------------VLQRIPLL--ISKSS-
TLTCGELSENQHKKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADCSRCVSYNRE
KQLKS---KELEENKKLECESSCIMNA-----------TGNPYLDD-----IGL--LQAL
TEKMVLAFLLQQG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-ARLLFLKDIYNIEIKEMLLLNLKKAISAA-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFGEDNFPKQV--FADDPD-TSGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQRI-KAHPS-SIQ-STFDLFFGAEEL------------EYK
CAKCE-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFFALKKNDQEVIISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGNISVSWPAT----K----------ESKD-I
LAPHIGSDKESEQK--------KGQTVFKGA--SRRQQQKYLGKNSKPNELE------SV
YSGDRAFIEKEPLA-HLLTYLEDTSLCQFHKAGGKPASS---PGTPLSK-VH-----FQT
VPENPKQKKYVKTS-KFV----AFDRIINPTKDLYEDKNIRIPE--RFQKVSEQT--QQC
D-----GMRICEQAPQQALPQSF----PKPGTQG--HT-KNLLRPT---KLNLQKSNR--
-------------------------NSLLALGSNKNPRNKDILDKIK--S-KAKETKRND
DK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYDDMQV-------L
GIQEAQMQ-EDRRCTG---YIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 124)

MAPIKIQGLVQIRSKNRNRHTRASQWK---------EAVIEIVERKQKVTMVF
SFKLEKRKRV-FQLGNNVAGVVVSCCEMGLHCLYLTLKGDTSLLIDKLSSADIEQLKAFL
DLA

ENSGT00440000033542_0_Linker_0_1 (124, 430)

HLSDTQDP-DDPMRKQEFLEGG----H------------------------------
PFCKKHPEPVCGARETAQEREAPL---------------------PGKMPLS--LAKSTS
RYAKKDKAEKEIKKRKRMAAPSV-D-VEEEI-LTEF-SPEPQK--KYKICNPRSKRGKGE
KPMAS---REQEKPTNWKLETSLMASA-----------RRKTNLDD-----TTVLSTQTL
AEERS-----GPK---------------------FNQE----------PPVCAEIQLPLD
TYAKQLNRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 714)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWDKVSCDDL-IKP
L-SQLLVLKDIRDVEIKGQLLMTVKKTISTV-ADTFLGDEQN-DAHEFLSQCLEQLKL-N
MEKLNAMCCSERENEA-------------AS-SRRFICPVAA-NFEIELHS-SIVCEGCG
EAT-LNTEVSNYLS-VDLPQGT-KDHPL-SIQ-KSLDLFFTPEKI------------EHN
CENCK-NKNSVLRYTWRRLPRVLIVHLKRYHFT-ANRMLVKSQQPVEISKYLTVA-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------REIPSF--TSESK-
-----GFFETPHGTRGRMQPSDGG--DGEQR-LEEM-NLVPRK--RLKSDGPKCLGSSKK
KAFCS---EQGGESM-ESEGGSFNGAS-----------TGNPGPDE-----SVD-APPTL
SAQSPLALLSEPS---------------------GAQN----------EPPWNESQLPWE
TLPE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

PL-GPGFP--NLGNTCYMNATLQSL-FAVPSF-ADDLLCQGIPWEMFPLDAF-ILC
L-SQLLVFKDLCRVETKKELLVNVKGSLSVV-SDIYSSNTQN-DAQEFLGHCLSQLKE-D
MEKLKSTGQGVRETADGHPEPQV--LAAQAA-PRGLACPVRA-NFEVELQH-AIVCKACG
AVV-CKTELSNYLS-ISLSQEQ--PGAW-SLQ-DSLDFFFRAEEL------------EYK
CGKCK-HGRSFVIQNVSRLPRVLIVHLKRYMLI-ASESQVKDSQPVGIPKYLILSPHCSE
DCRGPLLSDSQARREE-TQSLNASQDGTSGAVGSQEVET----D----------------
----------TE-----------------IS--SQKDRQERLSDSS--------------
------------------------------------------------------------
----PVTEVYEDA--------------T---------------G--TCQGLGDSE-----
-----------------ACPQG-------VDTQE--HS-EDKNEPT---GFHLQEDGR--
-------------------------TSPRALASGENPGNKDSLEAV---T-PREEAKSNG
AADQPQHAYRLISAVSHHGSSTESGH-YVSDLYDFA----KQAWFTYDDLRV-------S
QIPETTVR-EARRQDG---YIFFYMHSDIFDMLLTKAANSRTLNTEALEMSFLHGS---L
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSSIMVHGYAQIWNK----RTGMSEPQ---------GVFIEAVKGRKNFKLLI
YLRTGR-VKT-LKLNNNIKSVILQSYGANLSSLHVTFQNDGFLFVEKLSSTEAKQLKAFL
DSVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NCPEPH-MSPDKGEG--PST----CTGTQTR-KT---------------------
SLPKVREESGEGCSGTDKNRKRSA---------------------HRKKPLA--TSKSS-
TLTNEE-LENQQRKKKRMLPSDS-E-VNENEKSPIK-KNIVRE--KSNANPLKYKSYTWK
KQIKP---RKFKSNEKLA--SLLKANY-----------LEKPSVDD------TD--LQFL
TKSTLRQFQLALK---------------------CSEG---------G----SKLGLPRR
VYQQTV-W

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGLP--NLGNTCYINAVLQSL-CSIPLF-VNDVLNQGFPWGRISHDIF-SLC
V-ALLLTMKDIFNMRIKEKLLVTIIKAISVV-AEIFPMDAQN-DAHEFLSYCLGQMKE-A
LQKPNVVLDSENEFQEENSPQQV--FAGDSA-AGVPDCPVMT-NFEL-------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------K--------------SKSKN-S
VAKRVKAGKKPEPQ--------KSQHFLKGK--RRAQQQKDQ---GKPCMRES----EST
CLGDGASVEKKQLA-ISVMNLEDTSLPLSYRYADKPARR---PDT---E-AQ-----FPG
VPEHPKLKKSKKSN-RFA--ESDFDSVSQTTEDFSKNKKARVSE--RSQTVAEPI--DHP
D-----GMEIHKGDLQQILPEGF----PMPDAQE--HR-MNLRGCK---ELNPQKA----
-----------------------------------NPGNKDILVKK-TES-RTQKPGKKA
DGKGP-HTYRLIGIISHLGNSHNSGH-YISDVYDFK----KQVWFTYNDLLV-------S
RISESLVQ-KARLCTG---YIFFYMHNEIFEELLLRIKTSQSQFKCEPKSRSTK------
-ARKRS------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGAILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIAV---------------------TRTIPS----LTSTS
TPLRSGLLENRTEKRKRMISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
STKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRVYTCPVIS-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LALCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDSKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSMEVGKTTHQAS-----
------------------------------------------------------------
--------------------

-------MATLMAHGFVQIWSK----RMGMSTSK---------EAYIKTVERK-KIKLVV
HFTTGE-NKT-FQLSNNIKNVVLRSYGKKQNHLHLTFQNNSFLFIEKLSSRDAKQLKMFL
DRVHQNNIQPS-VRPVKDGGIFASI----TTPKVIN-KN---------------------
SFHKARKKPSSGSFQTGEGSGTSD----------------------QKMPSF--ALKSS-
KPSCKDLLENGYGKRKRMLSSGS-E-MNGKN-PKKS-NSVRKK--KSQTNPLMHVSHSEK
KKLRL---RVLKKDKKLEFEPLIKTVS-----------PEKPPLDG-----KGF--LQML
SEKMYLAFLLAPK---------------------YNAD----------YPEWDKLKMTFD
FYPE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KL-WQGLP--NLGNTCYMNAVLQSL-FSIPSF-ADDLLSQDFPWGKIPLDAL-RMC
L-TQLFVLKNIYNIKIKKRLLVNIKKAISTV-AEIFSGNIQN-DAHEFLGHCLDQMKE-N
MGKLNTIWKMKIESEEDNSAQQV--FAGSAA-TRVLICPVIT-NFEFELLR-SIICQACG
QVV-RKAEVSNYLS-INLPQGM-QALPL-SIQ-SAFDLFFGAEEL------------EYK
CEKCQ-HRSSVAVHKFSRLPRVLIVHLKRYIFN-QFWSLRKDDQEVVISKYLKLSSHCNE
STKPPLPVSKNAHNRD-FHILKVFQKMSAENLCLLAPST----K-------LTSASSL-F
PVPHMGPDKEYEPQ--------KCQILYKRS--HNEQQKKDLEKCSRRNMTKS----KLV
NVGDGAVIEKELLAPSLMMHLEERSSSLIHDNKGKSTRG---PET---------------
-SKNLKRKKYKKTN-VFV----DVESVSDTTEDVYGGKKPRISK--EFQKVAEQT--QQH
E-----RMRIYEQALQQALLQAL----LKPHTRW--HR-ENLRKHA---DLSFQGANV--
-------------------------NSLGASGSNKKRRNKQFLDMEKTKA-EAKKPKGNA
EMRDL-YAYRLIGVVSHLGKTPNSGH-YISDAYDFE----RQVWFTYNDLQV-------S
SIQEALMQ-EARLCTG---YIFFYMHNEIFEELLKREENSQSCSTETGETLQENS-----
------------------------------------------------------------
--------------------

-------MPSLVVRGFVQMWNM----KTGMSKLK---------EAFIETVEGK-DVKLVV
SFSSGK-CTT-FLLSNNIRNVVHRSFGDTQNFLHVTFQNNNFLFVEGLTSRDAEKLKTFL
ATICERQIKPS-SSPGRNREVLSSA----IPQQKII-KQ---------------------
PIHSVSEKFKSRPSDSGEENGTPV---------------------LHGLPVL--ISKSS-
----HEVPEYQGGKRKRKLHSDS-K-MNRKN-PDDE-SSSKSK--KSKKSPMEQRGKKEK
KEAKS------KNEAQGECSRPLLSLV-----------SGDPCLDG-----AGH--FRSL
FEKIYLAFLLEPN---------------------VDED---------EELEWEGLEITLE
LYPE

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

KI-WHGLP--NLGNTCYMNAILQSL-LSVLSF-VDDLLHQGFPRGKIPLDVL-SLR
L-AQLLVLKDTYNNKVKRNLLENLKEAISEV-AAIFSGNIQN-DAHEFLGHCLDQLKE-S
MRKLKVTMKAKMESEKKGSDQQA--FPGNAA-IQIPICPVVA-NFEFELLR-SITCKACG
HVV-FKAELSNYLS-MNLPRGS-KARHL-SVQ-STLDHFLGAEDL------------EYK
CEICK-HKHSLGVHKFLKIPRVLIIHLKRYNLT-EYWSLRKDQRAVAIPKYLNVSSHCNE
STEAPSPLNEYVHTRD-IQVLKIFQRMNSEALCLQMLSK----R-------MGSKSTD-S
RAS--ESNKKSALP--------KSPVFSKRS--SRDQQPANLENVSVVSGLET----TYP
WT-------NIAEATNVMTDLERTLLCLMFEDEDLSSSS---QATNLTE-VF-----LDD
VPERASSETYLESD-ASF--DIDIDSIDESTDEFYDDNSPKGEE----------N--HQT
E-----RARFYEKSLQEAILQTV----PNVSGQG--HM-EDFGRHT--EEISLQEAST--
-------------------------SSQGASCSYTSSA-NGISKSEKTKP-EAEKQKRSA
EMEDP-YAYRLIGIISHLGDDLNSGH-YVTDAYDFE----RQVWFTYNDMTV-------L
HVEEFPMQ-EGRVCTG---YIFFYMNSKTFEEVAKRVENTQLKGEVWETLQKENNK----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEIVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLPAA-MKPSQGSGSFGGILGSRTSQKETS-RQLSYSDNQASAKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGIA-----------------------RTIPS----LTSTS
TPLRSGLLENRTEKRKRTISTGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDR------TNVSSQTP
SAKRSLGFLPQPVP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPVSGEENSP-------DISA-TRAYTCPVIT-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
LTLCLDSDSEDE-LKRSVA---LSQRLCEMLGNEQQQ--EDLEKDSKLCPIEPDK-SELE
NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDTMETEKPK-TIT--ELDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDALGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAS-----
------------------------------------------------------------
--------------------

MLFCEER

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 122)

MAHLKINGLVQIRSTNRSKHTRASQWK---------EAVIEIVERKQKVNLVV
SFKLEERRRV-FQLGDNVTGVVVS-GELGLYHLDLTLRDDTSLLIDKLSSADVEHLKSFL
D

ENSGT00440000033542_0_Linker_0_1 (122, 430)

SSTPCESQQP-MEPMSSPDDLESS----D------------------------------
PFCREHQEAACGSLNTTPESGTPL---------------------SRKMPLS--MSNTTG
G---QKRGEKQGRKRKTEPSSSSAEV-NKDI-PKEN-TPDQKK--KSRRYYSRNRGGKAE
KAVTL---REQEKRSNWKLEPAFNSKS-----------YGRANLDG-----TILP-IATC
SDDRD-----VSI---------------------FGLE----------IITHNGVQSLPD
PYLNQLKRE

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GFP--NLGNTCYMNSILQSV-FGIPTF-AKDLLTQGIPWEKVSYDDL-IMP
L-SQLLVLKDIRDVEIKGELLTSVKKSISTV-ADTFSGNEQN-DAHEFLSLCLDQLKL-N
MEKVNAMWDTERRNTC----------AGSAG-TKRFVCPVGA-NFEFELHS-SIICEGCG
EAT-IKTEVSNYLS-IDLHHGT-KTHPL-SIQ-KSFDLFFTPEKI------------EHN
CEKCK-NKNSVLKYTLRRLPRVLIVHLKRYQVT-TDLLPVKSEQPVEISKYLNISSHCHE
NRKLPFPLANTS--------PDVSQGMMPGIFNQSMSSK----K-------VISESCD-P
MVLQVGSSVDAEIQ--------SFQIMYEDEDASEEQQQRGLESGS---MLEP----ELV
KTENRILRQKTSLATDSMMGDGYSFLPMLCE----PLSI---QDPGLAE-MG-----LQE
VPENPEFKNYEKIN-IYG--KSDGRTNTELSK----------------------L--YQN
H-----GSRIKGLFLPASL-ASV-------SSQE--DPEKDLSRSP---ELQEDDPHS--
-------------------------F-----------------AFG-------SDDSKDG
EMGDDLQNYRLVSVVSHFGSSPNSGH-YVSDVYDFQ----KQAWLLYSDVQV-------F
ESSDPSIQ-ENRLNSG---YIFFYMHNEIFEELLKKASECKVLSTSKEEKRDID-YFSTL
LNGLTYILEEF-------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MASLFLRGFVQIGNC----KTGISKSK---------EAFIEAVERKKEDRLVL
YFKSGK-YIT-FRLSDNIQNVVLKSYRGNQNHLHLTLQNNNVLFIEGLSSTDAEQLKIFL
DRVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 430)

NEVQPP-VRPGKGGSVFSST----TTQKEIN-KT---------------------
SFHKVDEKSSSKSFEIAKGS-GTG--------------------VLQRIPLL--ISKSS-
TLTCGELSENQHKKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADCSRCVSYNRE
KQLKS---KELEENKKLECESSCIMNA-----------TGNPYLDD-----IGL--LQAL
TEKMVLAFLLQQG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-CH

PF00443 // ENSGT00440000033542_0_Domain_1 (430, 1164)

GLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-ARLLFLKDIYNIEIKEMLLLNLKKAISAA-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFGEDNFPKQV--FADDPD-TSGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQRI-KAHPS-SIQ-STFDLFFGAEEL------------EYK
CAKCE-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFCALKKNDQEVIISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGNISVSWPAT----K----------ESKD-I
LAPHIGSDKESEQK--------KGQTVFKGA--SRRQQQKYLGKNSKPNELE------SV
YSGDRAFIEKEPLA-HLLTYLEDTSLCQFHKAGGKPASS---PGTPLSK-VH-----FQT
VPENPKQKKYVKTS-KFV----AFDRIINPTKDLYEDKNIRIPE--RFQKVSEQT--QQC
D-----GMRICEQALQQALPQSF----PKPGTQG--HT-KNLLRPT---KLNLQKSNR--
-------------------------NSLLALGSNKNPRNKDILDKIK--S-KAKETKRND
DK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYDDMQV-------L
GIQEAQMQ-EDRRCTG---YIFFYMHNEIFEEMLKREENAQLNSKEVEETLQKE------
------------------------------------------------------------
--------------------

-------MAPLKVHGPVRMRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNVGGIPKT-FQLSHNIKSVTLRPNGRKLCCLMLTLKDTSFLTIDKVPLKDANEMRMYL
DAVHQDRLHTA-GKPSQGSGSFGGVLGSRTTQKEAN-RQFSYIENQAPSKRVTVESKDEN
PFRKVLGTPARASIKNSSGTGAPG---------------------NRGNVAASP---TSA
VPHRTGLLESRSEKRKRAQPPSS-E-MSEDY-PKENDSSTNNI--AMSDPTWKYLNSSRE
KQLKL---KQEEENRTSGVLPLQSSSFYGSRSSSKEYSTSSSTLDR------SSVSSQTT
SAKRSLGFLSQPAP-------------LSVKKMRSNQD----------YTGWNKPRVPLS
THPQ

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QQ-LQGFS--NLGNTCYMNAILQSL-FSIQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLAKKDVSSPEVKKELLKKVKSAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKSEPVPNDDSSP--GRASDDLSA-TKVYTCPVIS-NLEFEVQH-SIICKTCG
ETV-TKREQFNDLS-IDLPRRK-KLFPSRSIQ-DSLDLFFRAEEI------------EYS
CEKCN-GKSAVVTHKFNRLPRVLILHLKRYSFNVALSLNHKVGQQVVIPRYLTLLSHCTE
STRLPLTLGWSAHSAV-SRPLKASQMVNSCTISTSTPCR----K-------YTFKSKS-S
ASLCVDSDSDDEPLKRSVA---NSQRLCNIQSRDQQQLQEEPEKSSKRSKMEGDK-PELG
NAGFDGMSEDELLAAVLEISKREASLSLSH-DEDKPTSS---PDTGFGD-DE-----IQE
LPENLETMETEKPK-APL--ESGPANFTEITKDFDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAREQKEDDDLKRAT---ELSLQEFNS--
-------------------------SLLDSVGSDEDSGNEDVLDMEYSEA-EAEELKRNA
ETKKTLWSRAHVSICSEVRVTALLCH-YISDVYDIK----KQSWFTYNDLEV-------S
RTLETTVQ-CDRDRSG---YIFFYMHKDIFDELLETEKSAQPLSTEVGRSIRQPL-----
------------------------------------------------------------
--------------------

-------TSPHKVHGFVQTWNK----RTGPSKLK---------EPITETVEREKDIQLIF
MFQGGKPIDIN------I-LECFRHYGERQNGLYLTFWN-N-LCLGKLSRTHTERLQILL
DIIRQNKHQWP-IKSESYWGVMESM----NGYTEPD-KT---------------------
PSSNVCRVPSAETFTTEEGNGTTF---------------------PQQ---L--LGKSP-
MLAKQGLPEKKDRKRKTTLSSSL-D-TDEGF-LEEN-ESVPSK--KFKKD----------
---SL---KDLEKDGSSKHGPSLRTAS-----------PGNSPLDE-----TVL-SPQSV
SDK-SLLLPSVPE---------------------RAQD----------DPQHDQDQLCLD
SHPEQL-Q

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFP--NLGNTCYMNSILQSL-YAIPSF-ADGLLGQGIPWENIPSDVL-IMP
L-SMLLALKDICNLETSQDLLRDIK-AISAV-AEIFSGNMQN-DAHEFLCQCLDQLKG-D
VEKVNTIWKTRREAGDENSPPEL--LAGDAA-TKVFVCPVAS-NFEFELQD-YVICKACG
QVP-VMIEPGNCFS-VNLHPKP-KASPL-SLQ-NCFDLFFTTEEC------------ERL
CEMCN-HKKAVVMQKFGRLPRVFIVHLKCYSLS-DTYALMKDDQE-VIPKYLSLSSNCNE
DTRPPLPLDSNAPVLD-PEVLNLTQEVISERVSPCTSSV----K-------LTWQSSD-S
SVLHVAPDEDAEQN--------TPQRIWQGR--PKEQQQSDLASGS---NLES----KLG
NARDREVREMEMLAAASVMDQGDISLLMNCEDESNPINN---PDRGLEE-VC-----CQE
EPENPEPKENEKTS-TLV--ELDFDHVSESSKDLCDYEKHKISE--GLRGVVEQLH----
------------------------------------------------------------
-----------------------------------ESVTKDIVGMEKTIA-KVKEPKGSM
QMGDALHSYRLISVISHIGNSPCAGH-YISDVYDFQ----KQAWFTYSDLRV-------A
EIPEAMVQ-EARLHSG---YIFFYMHNDIF------------------------------
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKIYGPIRIRSM----QTGITKWK---------EGSFEIVEKDNKISLVV
HYNTGGIPRM-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKEAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHAA-MKPSQGSGSFGPILGSRAPQKETS-RQLSYSDNQASSKRGSLETKDD-
PFRKVLGNPSRGSIKTVAGSGMAV---------------------SRTIPS----LTLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGSSLDR------SNVSSQTP
SAKRSLGFLPQPTP-------------LSVKKLRCNQD----------YTGWNKPRVPLP
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPFNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTLKTESILGEENSP-------DASA-TKVFTCPVIT-NLEFEVQH-SIICKACG
ETI-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
FTSCLDSDSEDE-LKRSVA---LSQRLCDMSGSEQQQ--EDVEKDSKLCRLEPGK-SELE
NSGFDRMSEEEVLAAVLEISRREASPVHSHDDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDAMETEKPK-TVA--EPDPTSFTEITKDCDENKENKTPE--GSQGEVDWL--QQF
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFLDSLGSDEDSGNEDVFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEAAVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKAPRQAS-----
------------------------------------------------------------
--------------------

--------------------PK----PGGITQMYSESNEKRNLDASIEMIQSED--SRPV
TFDSGLFAGV-FQS--GIQTTVFNPSPG---EISLNLTFHNNVSIKKLSCRDTETLKTFL
DRIHKKTSHGT-RKPDSDWGVHGRG----TTQEKSN-TS--CLQK----------TCDDP
RHQEMLS----------------------------------------------VTSKSP-
TPDGKRFFENPCNKRERRLSDLE-V-Y-KDL---KDKKSILNK--KFKKDCFKYARSNRK
KALML---EHVVRHAKSENRPSNIAS------------TGNSNLDE------VL-ATQPL
SAKRHLT----------------------FPST--SRDQNKQGNEV-VFLN---------
-PE-

PF00443 // ENSGT00440000033542_0_Domain_1 (425, 1164)

QL-WQGFP-NMGNTRCL-DVIVQLL-FAAPPFA-DDSLSQGIP-WEYSLDV-LILC
LSR-LLAYEDL-YSVDTKP-VD-IQKSISEFSE-IYFNSMQNDA-QEVLSHCLK---E-G
MENLKSG-KAEGLTGD-GITDPQIL-LAHAATK-EFVCPVIA-DFELELQRS-IICPSCS
EAV-CNTELNNDL--FISLSYE-KP--L-SIQDE-LDLFLGAEE------------RDYN
CEKCK-YNQKSKLPKVPTVHLK----------------------------------FCS-
------------LNAL-QVLVKDNQAVDI-SKDVSSPSR----N-------E----DT-K
WPLLLDSNPQTEEPQDKVSQDMISGAIISM----------KL--DERGNAVPEGS-QR--
----------------------EQLPR------DRKRIY---EKSILKD-SG-----VQS
VNIVPNPHD------------------------------VDTPE---------------Y
Q----------------------------------GE----IDPK-----LHLQEDS---
------------------------------QP--VEFGNKDNTGIQVT-E-TSDGAKRNA
AGEDLCHAYRLISVISHLCT--KSVH-YVRDIYDFA----KQHWFV-DDLWV-------F
QIKEAGMQ-EDRCRNG---YIFFYMHNRILETLLKRAETSQHTQTEMILY----------
------------------------------------------------------------
--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MHEIFGHSIPSI----Q-------PTSVSID-F
TVLQVGSNEDAEMQ--------NFQIMC------DDQQQLGLEGVS---GIDP----DLL
KTEKWMLCENTSPSWDS----------IICE----PISI---QDLGLRE-KG-----LQK
LPENPDSKNYKKIN-VYG--NPNHHTIIEICNNFCDLKEQKFLE--DTQEIGKQL--LQQ
H-----GKRIQKELLPWALPQSV------RGTQE--DMGKNMNRYS---EMVDPKIDA--
-------------------------DFLSALGYTESPRV---AGMD-------H

PF00443 // ENSGT00440000033542_0_Domain_5 (1075, 1164)

SDAANE
AMAEDPQNYRLVGVVSHFGSSQDSGH-YVSDVYDFQ----RRAWLLYSDVQV-------F
EIPEALIQ-ENRLHTG---YIFFYMQNEIFEWLVEXXXXXXXXXXXXXXXXXXXXXXXXX
XPTF--------------------------------------------------------
--------------------

-------MAALFLRGFVQIGNC----KTGMSKSK---------EAFIEAVEGEKKDRLVL
YFKSGK-YNT-FQLSDNIQNVVLRSYRGNQNYLHLTLQNNNVLFIEGLSSTDAEQLKIFL
DRVHQNEVQPP-VRPGKGGSVFSST----TTQKEIN-KT---------------------
SFHKVDEKSSSKSFEIAKGS-GTG--------------------VLQRMPLL--TSKSS-
TLTCGELSENQHEKRKRMLSSSS-E-MNEEF-LKEN-NSVEYK--KSKADRSRCVSYNRE
KRLKL---KELEENKKLECESSCIMNA-----------TGNPYLDD-----IGL--LQAL
TEKMVLAFLLQPG---------------------YSDG----------YTKWDKLKLFFE
LFPEKI-

PF00443 // ENSGT00440000033542_0_Domain_1 (428, 1164)

CHGLP--NLGNTCYMNAVLQSL-LSIPSF-ADDLLNQSFPWGKIPLNAL-TMC
L-AWLLFFKDTYNIEIKEMLLLNLKKAISAV-AEIFHGNAQN-DAHEFLAHCLDQLKD-N
MEKLNTIWKPKSEFGEDNFPKQV--FADDPD-TNGFSCPVIT-NFELELLH-SIACKACG
QVI-LKTELNNYLS-INLPQRI-KAHPS-SIQ-STFDLFFGAEEL------------EYT
CAKCK-HKTSVGVHSFSRLPRILIVHLKRYSLN-EFCALKKDDQEVIISKYLKVSSHCNE
GTRPPLPLSEDGEITD-FQLLKVIRKMTSGSISISWPST----K----------ESKD-I
LASHIGSDKESELK--------KGQAVFKGT--SRRQQQKYLGKNSKPNEPE------SV
YSGDRAFIEKEPLA-HLMAYLEDTSLCQFHKAGGKPASS---PGTRLAE-VH-----FQT
VPENPKRKKYVKTS-KFV----AFDRIINPTKDLYEDKNIRIPE--RFQKVSEQT--QQC
D-----GMRICEQAPQQALPRSF----PKPGAQG--HT-KNLLRPT---KLNLQKSNR--
-------------------------NFLLALGSNKNPRNKDILDKIK--S-KAKETKRND
DK-GD-HTYRLISVVSHLGKTLKSGH-YICDAYDFE----KQIWFTYNDMQV-------L
GIQEAQMQ-EDRRCTG---YIFFYVHNEIFEEMLKREENAQLNSKEVEETLLKK------
------------------------------------------------------------
--------------------

-------MSPLKIHGPIRIRSM----QTGITKWK---------EGSFEVVEKENKVSLVV
HYNTGGIPRI-FQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFL
DAVHQNRLNAA-MKPSQGSGSFGAILGSRTSQKETN-RQLSYSDNQVSSKRGSLETKDDT
PFRKVLGNPSRGSIKAAAGNGVTP---------------------ARTIPS----LTSTS
TPLRSGLLENRTEKRKRMLSSGS-E-LNEDY-PKENDSSSNNK--AMTDPSRKYLTSSRE
KQLSL---KQSEENRTSGLLPLQSSSFYGSRTAAKDYSPGSTNLD------RTNISSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQQQQ

PF00443 // ENSGT00440000033542_0_Domain_1 (427, 1164)

-LQGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQGIPWKKIPLNAL-I-R
RFAHLLVKKDICNSETKKDLLKKVKNAISAT-AERFSGYMQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKIEPVPGEENSP-------DISA-TRVYTCPVIT-NLEFEVQH-SIICKVCG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFNLGWSAQMAV-SRPLKASQMVNSCITSPSTPSK----N-------FTFKSKT-S
LALSLDSDSEDE-LKRSVA---LSHRLCEMSGSEQQQ--EDLEKDSKSCRIEPDK-SELE
NSGFDGMSEEELLAAVLEISKREASPSLSHEDDDKPTSS---PDTGFAE-DD-----IQE
MPENPDSVETEKPK-TIT--EPDPASFTEITKDCDENKENKTPE--GSQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQEFNN--
-------------------------SFVDSLGSDEDSGNEDVLDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTSSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQEASVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALNLEVGKTTRQVS-----
------------------------------------------------------------
--------------------

-------

PF16674 // ENSGT00440000033542_0_Domain_0 (8, 126)

MSPLKINGPIRVRSM----QTGITKWK---------EGSFEIVEKDNKVSLVV
HYNTGGIPRM-FQLSHNIKNVVLRPSGTKQSRLMLTLQDNSFLSIDKVPSKEAEEMRLFL
DAVHQ

ENSGT00440000033542_0_Linker_0_1 (126, 429)

NRLHVA-MKPSQGSGSFGAFLGSRASQKETN-RHLSYSDSQASSKRGSLETKDDI
PFRKVLGNPGRGSIKTVAGSGMAV---------------------SRTIPS----LSLTS
TPLRSGLLENRTEKRKRML-SGS-E-LTEDY-PKENDSSSNNK--AMTEPSRKYLTSSRE
KQLSL---KQAEENRTSGLLPLQSSSFYGSRAGSKDYSSGGTNLDR------SNVSSQTP
SAKRSLGFLPQPAP-------------LSVKKLRCNQD----------YTGWNKPRVPLS
SHQ-QQ-L

PF00443 // ENSGT00440000033542_0_Domain_1 (429, 1164)

QGFS--NLGNTCYMNAILQSL-FSLQSF-ANDLLKQSIPWKKIPLNAL-I-R
RFANLLIKKDISNSETKKELLKKVKNAISAT-AERFSGYVQN-DAHEFLSQCLDQLKE-D
MEKLNKTWKTEPILGEENSP-------DASA-TKVFTCPVIA-NLEFEVQH-SIICKACG
EII-PKREQFNDLS-IDLPRRK-KPLPPRSIQ-DSLDLFFRAEEL------------EYS
CEKCG-GKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTE
NTKPPFTLGWSAHMAI-SRPLKASQMVNSCITSPSTPSK----K-------FTFKSKS-S
FTSCLDSDSEDE-LKRSVA---LTQRLCDMSGKEQQQ--EDVEKDSKLCRLEPGK-SELE
NSGFDRMSEEEVLAAVLEISRRESLPVLCHEDDDKPTSS---PDTGFAE-DD-----VQE
MPENPDAMEAEKPK-TVA--EPEPASFSEITKDCDENKENKTPE--GCQGEVDWL--QQY
DM----EREREEQELQQALAQSL----QEQ-EAWEQKEDDDLKRAT---ELSLQELNN--
-------------------------PFLDSLCSDEDSGNEDIFDMEYTEA-EAEELKRNA
ETGNLPHSYRLISVVSHIGSTTSSGH-YISDVYD----IKKQAWFTYNDLEV-------S
KIQESSVQ-SDRDRSG---YIFFYMHKEIFDELLETEKNSQALSMEVGKTTLQTS-----
------------------------------------------------------------
--------------------