Query Results 

------------------------MSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LSVEDKDSKDA-------AGCSSEGDLNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPLSVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGETEGSC
QKLP-SGNCYSIYADHLNMDYVKN-------EPQSLRLEMTAAKNTNNNQSPSTPPGKSP
SNQRAVNSPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKEKLENGSK-CLHHSIYPPNGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GTG-EECR----------------
------D-------GGRKTFLY-SELSNK-N-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKRE-------TKSQCLSYA----------SLKAGSHDAKCK----NQSLEFSAMKAE
MK---GKDKCKVKQ---EE-CKSLTSAEKVSEHILKESLTMWN-QKQCNQGK-MP-----
------------------------S-K----------------------TC------PH-
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKEA-CED-DCPSGSM----SYMT
Q-SAQYEKCGGSQNAKALSMKHLETRGAP---GPSTSL--KDNQHLDSQKLDMSNMVLSL
IQKLLNESP-FNCEDLCE-G-EN--KHS-------EVRTNKSTSMFKKSD-REE------
--------------------------EQSQD---------NREVDFVSGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALTDLEEQ--------------------------------
---------------------------------------------ASSSNNSNFYQASGS
RC-----S------------------HEAGI

PF05716 // ENSGT00420000029845_Domain_5 (1112, 1223)

SQSSQDSNGPEVIVNNQCS-TSSLQRQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQPQDWKMSD-
------------------------------------------------------------
ESLSIFKEASHDPIRVLSWLRRDLEKSTAGFQDVRFKPG-ESSLG-----REMVSS-GDP
R-------------KGFCVDYYNTT---SRGSPGRLHFEMSHRENPH--QG---------
--PSMHP--GNGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENRCVHQSVYMG--D-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PNKSLSKVASELVNETVTACSKNTPSNKAPGSGDRASGTLQSPPNLKYKSTLKI
KESSKGARCPEDRPSSKKSFFY-KEVFESRNAGDAKEGGR-TLPAERKMFRG--HERPDD
FTTSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATIVLKRVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYSVI
FAKKTPETVRKTKDKSESYSLV----------SMKGM-GDPK------HRNVNFASMKTE
GKMR---EK--VCTPT-PKP--EKSCVETVGEHIIKEGLTLWHNSQQK-EGIP-------
--------------SCLQGSPFVTPKRQCK-------PVPDFPLAFPFDPCHFSLP--LQ
CPEKPENFLCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLE--AAGTS-----NLYP
MK--------------SPAISHESSLRSP---------RV-GADPEEVEKKDLMSVFFNF
IRNLLSETI-FKSDRSCDPK----AAKED-SPQ-------YERPATPSPAKLNECD----
---------------------------EPGGAFAGLTKMVANKLD-----SHMNGQMVDH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPESLY
EC-LSTKGTGTAETLLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MTD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDVYSPGDNQPHDWKI---
------------------------------------------------------------
-------XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXX-----GDMTPS-ADP
R-------------KGFSVDYYNTT---NRGSPGRLHFEMTHKENPP--QS---------
--PSALP--GHGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVHQSVYMG--D-
-EPG--PNKTLSKVASELVNDTVSACSKNVNPEKAPGSGDRASASSRSPPNLKYKSTLKI
KESTKESKGPDDKPASKKSFFY-KEVFESRNAGDAREGGR-SLPGERRKFGG--QERPDD
FTSSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FK-KCPETMRKTKDKAESYSLI----------SMKGM-GDPK------HRNVNFA-MKSE
AKLK---EK--VYSP--HKPE--KTCAETLGEHIIKEGLTMWHKNQQK-ECKS-------
--------------PGFQRAAFEMPDQQCK-------SPPDIPCACPEDISNFGPL--LC
HPENADSIMYDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAGST-----NFPS
KK--------------SPVVPDESSLKSP---------HL-VGDREQAEKKDLMSVFFNF
IRNLLGETI-FKDRSCSKVDH---PVKEESAPVXXXXXXXXXXXXXXXXXXXXXXX----
-----------------------------XXXXXXXXXXXXXXXX-----XXXXXXXXXX
XXXXXXXXXXXXXXXXXX--XXXXXX----------------------------------
------------------XX----X-XXX-----------XXXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX-XXXXXXX------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

---------------MIAYCGTAKMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGDY
HKIP-SENCYSVYADQLNMDYLNK-------GPQSLRLEMAASKNTNNNQSPSNAAAKSP
SNQRSVATPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSMYTSTGE-
-KGKTSPRSAVSKIASEMAHEAVELTSAEMR-----GNG-EECR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-K-----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTHDPKCK----NQSLEFSAMKAE
MK---GKEKCKGKP---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNQGRVPN-----
--------------------------K----------------------VC-------A

PF05716 // ENSGT00420000029845_Domain_2 (720, 1066)

S
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDV-CEE-ECPGSSM----GYMS
Q-STQYEKCGGGQSSKSLSMKHFESCGAP---GPSACS--KES-QLDSQKLDMSNMVLSL
IQKLLSESS-FSCDELAE-G-ENK-RC--------DPRSSKPVSMPKRL----E------
--------------------------EQCPD---------NPEMDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAA-------GGP
RC-----G------------------REGAMS-QYHDAPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLVNL--------------

------------------------MSD-HIDWLHSHRDVCKVDLYSQTGQQDQRRKVIC-
LWWIVSTLASRKIKDSKDA-------GGSNSDGGLNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQTPSDHICVFNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGETEGKF
HKLP-SGNCYRVYADQLNMDYVTN-------GPQSRHLEMTAAKNTNNNQSPSTPSPKSP
NTQRAVISPGGECSVDDLSFYINRLASLVIQMARKEIKEKLEGRNK-CFHHSIYPPPGD-
-KGKNSPRSALSKIASEMVHDA

PF05716 // ENSGT00420000029845_Domain_2 (323, 1223)

VEVTSAEMR-----GTG-EDSR----------------
------D-------GGRKTFMY-SELSNK-S-----KSG--DK----QMFQRDSKEF---
-ADSISKGLMVYANQVASDMMFSVMKTLKVHSSGK-PIPACAVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVGAL
LGEKKE-------TKSQSVSYA----------SLKAGSQDPKCK----NQSLEFSAMKAE
MK---GKDQGKMRP---EQ-CKSLTSAEKVGEHILKESLTMWN-QKQGNQGK-MT-----
------------------------S-K----------------------AC------VN-
REEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDL-HEE-DCPGSST----SYTA
Q-SAQYEKCGSGQTAKALSMKHLESRGAP---GPSTSL--KENQHVNCQKLDMSNIVLTL
IQKLLGESS-FNCDDISE-G-EN--KHS-------EPSTSRGTSMFKRPD-RGE------
--------------------------EQCQE---------NQELDFASGLKQVNRQFIDQ
LVESVMKLCLIMTKYGNNGAALDELEEQ--------------------------------
---------------------------------------------AASVNNAN-YQASGS
RR-----S------------------QSGVMPQNYQDSSGPQVIVNNHCS-TSSLQKQLQ
AVLQWIAASQFNIPTLYFLGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLHEVMKFAKE
RQLDEAVGNVARKQLLDWLLTNL--------------

---------------VIVYSSTTKMSD-N

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPAGQQDQDRKVIC-
FVDVST--LNVEDKDAKDG-------TDSCSEGDLNLENLEEKEIIVIKDTEKQDQSKXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX------XXXXXXXXXXX
XXXX-XXXXXXXXXX-X-XXX--X-------XXX--XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-
-XXXXXX--XXXXXXXXXXXXXXXXXXXXXX-----XXX-XXXX----------------
------X-------XXXXXXXX-XXXXXX-X-----XXX--XX----XXXXXXXXXX---
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX-----X---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXX-------XXXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXGKMKP---EQ-CKSLTSAEIVSEHILKESLTMWN-QKQGNQGKVPS-----
--------------------------K-----------------------I------SPN
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDL-FED-EGPGSTM----GYMA
Q-STQYEKCGSGQSGKSLSMKHLESRGSP---GPSTSL--KENQQQDSQKQDMSNIVLTL
IQKLLSESP-FNCEDISE-G-EN--KSS-------ESRTSKSASISKKPD-RVE------
--------------------------ELCQE---------NQEFDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSSNGAALAELEEQ--------------------------------
---------------------------------------------AALANNPN-YQASSS
RC-----G------------------HDHMMSQNHQDIPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DEGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNIARKQLLDWLLTNL--------------

---------------MMAYSDTTMMSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HRAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEMTAAKNTNNNQSPSAPPAKPP
STQRAVTSPDGECSIDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 341)

HKEIKDKLEGKSK-CLHHSICPSPGN-
-KERISPRTAASKIASEMAHEAVELTAAEMR-----GTG-

PF05716 // ENSGT00420000029845_Domain_2 (341, 1223)

GKSI----------------
------------------------------------------------------------
--------------------------------------P-AEVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNATDIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---ERDKGKMK----SDPCKSLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKQLESHRAP---GPSTCQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KRS-------EPRVSKEASMSKRSD-KGE------
--------------------------EQCQE---------HQELDCISGMKQANWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASANKPNF---RGT
RC-----I------------------HRGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLTNL--------------

-----------------------MMTD-SIDWLQSQNGLCKVDRYTPSEEEEQSWTT---
------------------------------------------------------------
DSAKLFQQTSSDPLKVLTWLRKDLEKCAIGVQNVLNASN-NAG-GARSRETSVERQNM-Q
KRNAHSPTEYSICDEEFSVNVSSN------RGSPNFHLTMKGTCQKG---SKD-------
EESDRSTSPNTNGDPDEVSFYCNRLSNLAIAMARKEMNDRSDGNPA-CIHKSIFAS-GDH
--GHRDIGVGTDDIKHSPPKA------SEY------------------------------
-------KYEGSPNSKKKAAFYYKEEETD-LPNKSDPGSD-EAKGCNHRKRFGPDEY---
-TNSLSKGILVYANSVVSDMMVSVMKTMKVKVND--SNIACAVLKKVLLKHSKEVVSDLI
DSCMKNLHDVTGTLMTDSDF---------VSAVKRSLFTQGSQKASEIVQAMLNRLHNAL
IVQKQVNE----KAKSQRMTFA----------TVKTAA-GCDAK----TQNMRFSAAKTE
SFK-----------------EKEATCAETVGNHIIKEGLSMWHQKQQN-ENVGSN-----
------------------------V-Q----------------------AK------PAW
NLENQDVGNLATDSWARDLIVTALMLIQYHLHQQENAIKE-AGDCGRGSSKTGNTFGFMS
QDK---SGN---AAML----------KQYD---SL--KKSDDEQSEANPENDMSSVVVML
IQKLINETVNK-LGGNAGTLMADEAYKG----AYKSPEVPGNSGSSEV------------
-------------------------DHSYDDAIAGLTKMILDQFDVNKAEGGGSGPFFDN
LVDTVTKLCLMIAKYSNPESGLGDMVDA--------------------------------
---------------------------------------------DDASGPLYS----KD
IE-----S------------------GESRIGSGED

PF05716 // ENSGT00420000029845_Domain_5 (1117, 1223)

TLSHRKVVVTNQNAAENIHNKQLQ
AVLQWVAASQLNVPVLYFMDD-DEETLNKLQQLSMVAV---ERGYSVGEVMQAVLKYEKE
RQLGEALGNFVRMPVLDWLLQNL--------------

------------------------MSE-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDAYSPEDGQAQEWKP---
------------------------------------------------------------
-------DAPTDPIRVLSWLRKDLEKSTAEFQDATFKPG-EPPAG-----GEMTTS-PDP
R-------------RGFSLDYYNTT---NTGQPGKLHFEVTHKETPP--TG---------
--P---T--GNERAVDEVSFYANRLTNLVTAMARKEINEKIDGLENKCVHQSVYMG--D-
-EPK--PNRSLSKVASELVNETVTACSTAAVSDKAPGAGGRGEA-SRSPPTMRYKNTLKI
KENTKGGKNLDDKPASRKSFFY-KEVFECQNVGDAKEGGR-PLPGERKMFRG--SERTND
FTNSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATVLLKKVLIRHAKEVVSDLI
DSFMRNLHNVTGTLMTDTDF---------VSAMKRGLFSHSSQTATDIMDAMLSQLYNVI
FPQKAPEPT----KIQECYSLF----------SMKGM-GDPR--------PFIFPTMKSE
AKFR---EK--IYSPE-PTP--EKSCAETLGEHIIKESLTLWRKSQQK-DCKS-------
--------------PGPQRAAFSVFNKECA-------PGPDNPVECIRETCN-SPR--TG
GPEKVENVMYDSESWAKDLIVSALLLIQYHLAQGGRMDGQSFLE--AAGNT-----SLPP
MK--------------PPVSPDAASLKHP---------HFMGDNQ--EEKKDLMSVVFNF
IRNLLGETI-FKVQ---DPKGPEQPAKEE-SQP-------CESPTTPSPTKGCDGE----
---------------------------ESGGVLAGLTKMVANQLE-----GHMNGKFVEH
LTDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDEKSGDASRPASAFPDNLY
EC-LPVKGTGTTETILQNAYQTIQNELRSLSGPSPEGCAVPKVIVSNQNLADTVQNKELQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSARAV---DKGRSVGEVLQSVLRYEKE
RQLDEALGNVTRLQLLDWLMMNL--------------

------------------------MAD-RVDWLQSQSGVCKVGVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFV-----EEVAYP-VDQ
R-------------KGFCVDYYNTT---NKGSPGRLHFEMSHKENPS--QG---------
--LISHV--GNGGSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGAENKCVHQSLYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAP-GLRYTSTLKI
KESTKEGKCPDDKPGTKKSFFY-KEVFESRNAGDAKEGGR-SLPGDQKLFRTSPDNRPDD
FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMKHAKEVVSDLI
DSFMKNLHGVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRRARDKSESYSLI----------STKSRAGDPK------LSNLNFA-MKSE
SKLK---EN--LFST--CKLEKEKTCAETLGEHIIKEGLHMWHKSQQ----KS-------
--------------PGLERAAKLG----NA--------PQEVSFECP-DPCEANPPHQPQ
PPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLE--AAAST-----NFPT
NKP----------PPPSPVVQDECKLKSP---------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEE---
---------------------------ATGGALSGLTKMVANQLD-----NCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GEEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSD-KVDWLQSQNGVCKVDVYSPGDSQAQDRKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-ESTFG-----GEMSNS-GDP
H-------------KGFSVDYYNTT---TKGPPGRLHLEITHKENPF--QG---------
--PRAQL--GNESSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINETIDGSENKCVHQSLYIG--N-
-EPI--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKVASELVNETVSACARNAAADKAPGSGDRASESSQKPPHLKYKSTLKM
KENTQERPGPEDKPDSKKSFFY-KEVFESRNADYAQEGGR-FFPWERKMFRG--RERADD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATVLLKKVLLKHAKEVVSDLI
DSFMRNLHNVTGTLMTNTDF---------VSAVKRTVFSHGRQKASDIMDAMLGKLYNVM
FAEKVSEHIRKAKDKAESYSFL----------SMKGM-GDPK------KRNVNFA-MRSE
AKLR---EK--MYSE--AKSEKEKTCAETLGEHIIKEGLTLWHQN-QK-ECKS-------
--------------PGFQHAAFEAPDAQCK-------PAPDISFEYPEDICNLSPP--PC
PPEKPENFMFNSDSWAKDLIISALLLIQYHLAQGGRRDAQSFLE--AAGTP-----NFPA
NK--------------SSVVPDESCLKTA---------HN-VDDQEQAEKKDLMSVFFNF
IRNLLSETI-FKRGHCSEPKVPEQQLKED-INL-------CERPLTSSPPKPCEDD----
---------------------------ETPGAFSGLTKMVINQLD-----GNMNGQMVEH
LMDSVMKLCLIIAKSCDT--SLTEL-----------------------------------
----------------------------------------EDDKSGDASRLTSAFPDSLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGQSPEGCAPPKVIVSNHNLIDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKQ
RQLNEAVGNVTALQLLDWLMVNL--------------

---------------IIACSDTTMMSD-DIDWLHSRRGVCKVDLYSPREQQDQDRKVIC-
FVDVST--LNVEDKDCKDA-------GGSSSEGDLNLGNLEEKEIIVIKDTEKQDQSKME
GSVCLFKQAPSDPLCVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDREGGY
HKIP-SGNCYSVYADQLNMDYFNN-------GHQSLRLEMTAAKNTNNNQSPSTPLAKSP
STQRAVTSPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIRDKLEGGNK-CLHHSIYPHTGD-
-KGKSSPRSAASKIASEMAHETVELTSTEMH-----DTG-EDGR----------------
------E-------GGRKTFLY-SELSNK-N-----KCG--EK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVGAL
LGEKKE-------TKSQSLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKVKVKP---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-MT-----
------------------------T-K----------------------IC------TN-
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKCKDP-IEE-DCPS-TM----NYMA
Q-STQYEKCGSNQSAKTLSMKHLESRGAP---GPSTSL--KENQHLDSQKLDMSNIVLSL
IQKLLSESP-FSCDDLCE-G-EN--KRS-------EPRTGKAACMSKRPD-RRE------
--------------------------EQCQD---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALASNLNF---SGP
RC-----S------------------HNGAVS

PF05716 // ENSGT00420000029845_Domain_5 (1113, 1223)

HNYQDSPGPEVIVNNQCS-TSSLQRQLQ
AVLQWIAASQFNVPLLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSE-RVDWLQSQNGVCKVDVYSPGDSQPQDWKM---
------------------------------------------------------------
-------EASTDPVRVLSWLRRDLEKSTAEFQDIRFKPG-ESSFG-----EETANP---G
N-------------RGFCIDYFNNP---QKGSPGRLHFEVTHKETPS--QD---------
--PCPQA--GKGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVRQSLYVG--D-
-EPV--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PKKSLSTVASELVNETVSACANTTSPDKAPGSGDRASGLSQSPPNLKYKSTLKI
KECTKESKCPDDKSASKKSFFY-KEVFESRNAGDAKEGGK-SLPGEKKMFSG--QERPSD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------ISAVKRSLFSQGSQKATDIMDAMLGKLYTVM
FAKKFPDNLRKTKDKSESYSLL----------SMKGI-DR----------NMNF-TMKSE
AKVK---EK--IYSS--GKSEKEKTCAETLGEHIIKEGLTMWHKTQKK-ECKSPDFEP--
----------------------AATNKQKN-------PAPDIPFEC-LDPCSFSPS--LH
FPEIPENFMCDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAGSS-----NFPI
TK--------------TPVVLDESSLKTP---------HV-VCDQEQSEKKDLMSVFFNF
IRNLLGETI-FKGDNSCESKAPEKSDKEKDCNQ-------GERPMTPSPK-LSEGD----
---------------------------E-AGAFSGLTKMVANQLD-----GNMNGQMVDH
LVDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDEKSGDASRPNSAFPESLY
EC-LPVKGTGTAEALLQNAYQAIHNELRCASGQPPEGCTAPKVIVSNHNLSDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

--------------------------------GRKREGPN---REE-PKRGEPQRGRIC-
FVDVST--LNVEDKDSKGA-------VGSRSEGELDLENLAEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGEY
HKIP-SENCYRVYADQLNMDFLNQ-------GSQNLRLEMAASKNTNNNQSPSNPAAKSP
SNQRSVATPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVVQMARKEIKDKLEGGSK-CLHHSIYACPGE-
-KGKTSPRSAVSKIASEMAHEAVELTSAEMR-----GNG-EECR----------------
------D-------GGRKTFLY-SELSNK-N-----KCGE-K-----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTHDPKCK----NQSLEFSAMKAE
MK---GKDKCKAKA---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNPVRVPN-----
--------------------------K----------------------VC-------A

PF05716 // ENSGT00420000029845_Domain_2 (720, 1078)

N
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDV-CEE-DGPGSSM----GYMS
QQSTQYEKCGSGQSAKSLSMKHFESRGAP---GPSACG--KES-QLDSQKLDMSNMVLSL
IQKLLSESP-FNCDELPE-N-E--KRCP-------EPRPSKAAPMCKRP----E------
--------------------------DQCPD---------NSELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAA-------SGS
RC-----G------------------REGAMS-QYQDAPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-RVDWLQSQNGVCKVDVFSPGDNQPQDWKMSD-
------------------------------------------------------------
ESLSIFKEASTDPIRVLSWLRRDLEQSTAGFQDMRFKPG-ESSFG-----GEMANS-GDS
R-------------KGFSVDYYNTM---NKGSPGRLHFEMTHKEAPC--QG---------
--TSAHA--GNDSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENRCIHQSLYIG--D-
-EAK-P

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PIKTLSKVASELVNETVSICAKNAVPDKVPGSGDRASGSSQNSPGVKYKSTLKF
KEYNREGKSPDDKPASRKSFFY-KEVFESRNAGDAKEGGR-SLPAERKIFRG--QERPDD
FTTSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--STIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FTRKPPEIVRKAKDKAESYSLF----------STKGL-GDPK------NRKINFATMKSE
AKLR---EK--LCSST-FKPEKEKTCVETVGEHIIKEGLTLWHKKQKK-ECKS-------
--------------PVFQHATFAAPNKQYS-------PVPDIPLGYPQGTCN-SPP--MS
HPEKLENSMYDSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGSS-----NLPA
TK--------------SPTVPDESSPKSP---------QM-GRNQEETEKKDLMSVFFNF
IRNLLGETI-FKCDQRCEPKVN-----EDESNP-------CERPTTPPPTKGCEGD----
---------------------------EADGPLAGLTKMVANQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFADNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGVSGHSPEGCAAPKVVVSNQNLSDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSD-RIDWLQSQSEVCRVDVYSPGDNQSPKWKL---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEKSTAGFQDVRFQPR-ESSPG-----ETT-NA-EDP
S-------------KAFSVDYYNTT---TKGSPGRLHFKISHKENPC--QG---------
--PRAQI--GNKSSVDEVSSM-------LILWPARRLMRQSMVLENKCIHQSFYVG--D-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1169)

-PNKSLSNMASELVNETVSACAGNAVPDKAPRSGDRASRSLQSLRNLKYKSTVKI
KESNKGSQGP-----SRKSFFF-KEVLESRNAGDTREGGR-------RLFRG--QERPDD
FTAPVSDGIMMYANSVVSDMMASIMRTLRIQVKD--TTIITIVLKKVLLKHTKEVVSDLI
DSFMKNLHSATGTLMTDEDF---------VSAVKRNVFSHGSQKSSDIMNAMLSKLYDVM
LAKKVPEIIRKTEDRSESFSLF----------STKGK-GDPK------NRNVNFA-MKSV
DELR---EK--VYPA--SNPAKEKTCAETLSEHIIKEGLSLWHDSQQN-KCKS-------
--------------PGLQRAASGAPNKQYM-------SAPDIPLGYSHDACDLSPP--LC
HPEEPEDLMCDSKSWAKDLIVSALLLIQHHLALGGRMDAGSFLE--AASTT-----NFST
NKP----------PE----VSNKS-----------------CVNQEQAEKKTLMSVFFNF
IRTLLSETI-FKSGHSPEPKVPEEPVREEDTHR-------CERTMTPSSASPCECD----
---------------------------EAGGPLSGMTKMIVNQPD-----GDMDGKMVEH
LMDSVMKLCLIIAKSCDS--HLTEL-----------------------------------
----------------------------------------GDENSGDAGGPTTAFPDNLY
DC-LAVKGTETAEAILQNAYQAIHSELRGASRQSPEECPAPKIIVSNHKLMDTSPDKQLQ
AVLQWVAASELNVPILYFAGD-DEEIQEK-------------------------------
-------------------------------------

---------------MIACCETTNMSD-NIDWLHSRRGVCKVDLYSPTGQRDQDRKVIC-
FVDVST--LNVEDKDCKGA-------TGSRSEGKLNLENLEEKEIIVIKDTEKQNQSKME
GSVCLFKQAPSDPLSVLSWLFSDLQKYALGFQHALSPTA-SSC------KHKIGEIEGEC
YKMP-SENCCSVYADQLNLSHTAN-------GPQSLRLEMTAAKNTNNNQSPSNPATKPP
NNPRSSAIPDEECPMDDLSFYVNRLSSLVAQMARKEIRDKLECGSK-YLQHSMYPA-AD-
-KGKNNPRSAVSKIASEMAREAVELTSAEMH-----GTG-EECR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-R-----QMCQRDGKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVILKRVLLKHTKEIVSDLI
DSCMKNLHNLTGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVNAL
LGERKE-------TKSQSLAYA----------TLKTGIHDPKCK----NQSLEFSAMKAE
MK---GKDKCKVKT---DPG-KSLVSAEKVGEHILKESLTMWN-QKQGNQCKMTS-----
--------------------------K----------------------IT-------TC
KDEKRGNLSPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-CED-DCPGSSM----GYMS
H-STQYEKCGGGQSSKSLSMKHIETRGNP---GPSTCV--KENQQLDSQKLDMSNMVLSL
IQKLLSDSP-FSCDELSE-N-E---KCC-------DPRTNKGASVSKRPD-RGE------
--------------------------EQCQD---------STEMDFISGMKQMNRKFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALMSKTNF---NCS
RS-----C------------------REG

PF05716 // ENSGT00420000029845_Domain_5 (1110, 1223)

TMSQNYRDTPGPEVIINNQCS-TSNLQKQLQ
AVLQWMAASQFNVPMLYFMGD-NDGQLKKLPEVSVKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMAKKQLLDWLLANL--------------

----------Y-SPRSDSTPKSQKMSQ-EVDWLHSQAGVCKVDLYNPEGGKDQDRKVIC-
FVDVSS--LNIKNTDDDTGKDAAGQSKGNESATGLDLGKMQDKEVIVIKDSDTPEQSKTE
GAVCLFKQGSTEELNVVSWLFDDLQKYACGFQHALTPSP-TPP------KPKPSAA--DK
MS-----------------------------------------Q-NNNN-----TAFKSS
ES---------QKAADEVAGTVQKLCALVMQMASKEISENLEDAASKCIRQAIYATK-D-
--GKPLPPSSVSKVASEMVNKAMESAQEPSN-----KSSQDN------------------
------MGKKDDGKGKKTSLFY-GEVCSN-QSESMQEDD-----------PRPRQSG-RP
DTSSFNKGLMVYANKNAKDMTFSFVNATKVHK--RAPLPACVVLKRVFLKHTKDVISDLI
DSTMKNLHNVTGVLMTDSDF---------VTTVKKNLFHAGTQKSTEILEAMVLRMYNAL
MTETK--------ERGHSLVYS----------LLKTGCSLDA-----NSPNMHFASLKGG
IHTR---EK--VRT------DMGQTSAQKVGETIIKDGISMLRSKAGGGKCSD-------
----------------------------------------------------------RP
HDKRPEKSSTTTEFLAKDLILTALMLIQQHLLTQYK--EP-VVE-SNTSSF-----GYFE
K-GGKHGSKS-------------SHN------------YKGDPQQQEYQRGEIQSALLSI
IQKVLQEAG-FSVDECEI-T-KNVKQYS------YDDRSTKT------------------
--------------------------TKSKQ---------YCSDVDSENMEQINKKFIDQ
LMESVMKLCTYMTKNYSDEQGTYITARN--------------------------------
---------------------------------------------KG--VS--S-PDSMA
GQ-----K------------------GRSGYSGKPL

PF05716 // ENSGT00420000029845_Domain_5 (1117, 1223)

VPAGSEVIVNNQNANTSSQNKELQ
AILQWMAASHFQVPNLTFMNE-NDEELKKLPQLADKAA---KKGASVGDILQEVMRYFEK
QQVDAAVGNMPRSGLLDWLLANL--------------

------------------------MAD-RVDWLQSQSGVCKVGVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFV-----EEVAYP-VDQ
R-------------KGFCVDYYNTT---NKGSPGRLHFEMSHKENPS--QG---------
--LIAHV--GNGGSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGTENKCVHQSLYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVTACSKNIAGDKAPGSGDRALGSSQAP-GLRYTSTLKI
KESTKEGKCPDDKPGTKKSFFY-KEVFESRNAGDAKEGGR-SLPGDRKLFRTSPDNRPDD
FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMKHAKEVVSDLI
DSFMKNLHGVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRRARDKSESYSLI----------STKSRSGDPK------LSNLNFA-MKSE
SKLK---EN--LFST--CKLEKEKTCAETLGEHIIKEGLHMWHKSQQ----KS-------
--------------PGLERAAKQG----NA--------PQEVSFECP-DPCEANLPHQPQ
PPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLE--AAAST-----NFPT
NKP----------PPP-PVVHDECKLKSP---------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSSRNCESNVHEQNTQEEEINPCERPMTPCERPITPPAPKFCEDEE---
---------------------------ATGGALSGLTKMVANQLD-----NCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GEEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MTD-KVDWLQSQNGVCKVDVYSPGDHQSTDWRM---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEESTAEFQDSRFKPG-ESLFD-----EEVANL-GDQ
R-------------KGFCIDYYNTT---TKGNPGRLHFEVTHTENPA--QG---------
--PNAQP--GNTSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIHGSENKCVHQSFYMG--D-
-EPV--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PHKSLSTVASELVNETVSECSKNMA-DKTPGSGDRALGSLQNPSSLKYKSTLKI
KENSNENKGPNDKPGSRKSFFY-KEVFESRNAGDAREGGR-TLPGERKMFRM--QERPDD
FSTSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIVTILLKQVLIKHAKEVVSDLI
DSFMRNMHNVTGSLMTDTDF---------VSAVKRSLFSQGSQKATDIMDAMLGKLYNVM
FAKKCPENVRQTKDK--SYSLI----------SMKTR-GDPR------NRNVNFA-MKSE
AKLR---EN--MYST--CKPEKEKTCMETLGEHFIKEGLTMWHKHQQ-RDCKS-------
--------------PGLENPACDK--PCSN-------PPPDMCFEQQ-ETCEFNAC--PQ
QPENFENFMCDSNSWAKDLIVSALLLIQYHLAQGGKMDAQSFLE--AASTS-----NFPT
K---------------PPGTHDESRLKS----------PHRMCDQEQSEKKDLMSVIFNF
IRNLLSETI-FKSRCKCEPKVPEPQCKDEDFDP-------CDRSMTSSPPKYCEDE----
---------------------------ETGGTFSGLTKMVANQLD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDEKSGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQTAYQSIHNELRGLSGHPPEGCEVPKVIVSNHNFTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSASAV---EKGRSVGEVLQSVLQYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

MISHVCTSSSPCSWKASQSILSKVMSE-RVDWLQSQNGVCKVDVYSPGDNQTQDWKMSD-
------------------------------------------------------------
ESLSVLKEVSKDPVRVLSWLRRDLEKSTAGFQDVRFKPG-ESPFG-----EETTNI-GDP
H-------------RGFSVDAYNTT---NKGSPGRFHFEITHKESPA--QG---------
--PGAVP--GNGRSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSEKKCIHQSLYMG--D-
-EPA-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKVASELVNETVSACSKNNDSDKAPGSGDRASGSS-NIPNLKKKSTLKI
KESTVESKGAEDKPVSRKSFFY-KEVFESRNAGDAREGGR--LPGERKLFRG--QERPDD
FTTSISQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYTVM
FTKKFPENLRKTKDKQESYSLM----------SMKGM-GDPR------NRNVNFA-MRSE
AKLR---EK--MYS-A-PKPEKEKTCAETLGEHIIKEGLTMWHKSQQK-ECKSPGFERKS
PSLERKSPGFERKSPGFEHVTFSAPNKQYK-------PAPDIPFGFPQDTCTLSPL--LH
QPEQPENFMYESDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAGST-----NLPT
KK--------------CPVVPDESSLKIP---------HV-VGDQEQAEKKDLMSVFFNF
IRNLLGETI-FKSDNSPEPKMPEQPAKEESSRH-------CERPVTPSPIKLNEGD----
---------------------------ETGGAFSGLTKMVANQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------AEDKSGDAGRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGISGQPLEGCA-PKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSD-KVDWLQSQNGVCKVDVYSPGDSQAQGWEM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-ESSFG-----GERSNS-GDP
H-------------KG--------T---TKGTPGRLHFEITHKENPF--QG---------
--PRAQL--GNGNSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEAINGSEDKCVHQSLYIG--N-
-EPI--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKVASKLVNETVSACSRNAAPDKAPSFGDRASESSQKPPNLKYKSILKM
KESTRERQGPEDKPDSKKSFFY-KEVFDSHNADYARAGGR-FFPWERKMFRG--QERADD
FTTSVSERIMTYANSVVSDIMVSIMKTLRIQVKD--TTIATILLKKVLLKHAKDVVSDLI
DSFMMNLHNVTGTLMTNTDF---------VSAVKRTVFSHGSQKASDIMDAMLGNLYNVM
FADKVSEHIRKAKDKAERYSLL----------SMKGM-GDPK------KRNVNFA-MRSE
AKLR---EK--MCSE--AKSEK-KTCAETLGEHIIKEGLTLWHKN-QK-ECKS-------
--------------PGFQHAACEAPNTQCK-------PAPDISFEYPEGTCNFGPP--QY
PPEKPENFMFDSDSWAKDLIISALLLIQYHLAQGGRRDAQNFPE--AAGTT-----NFNA
NK--------------SPVVPDESCLKTA---------HN-VDDQEQAEKKDLMSVFFNF
IRNLLSETV-FERGHCSEPKVPEQLVKED-TNL-------YERPLTSSPPKPCKDD----
---------------------------ETPGASSGLTKMVTNQLD-----GNMNGKMVEH
LMDSVMKLCIIIAKSCDT--SLTEL-----------------------------------
----------------------------------------EDDKSGNVSRLMSAFPDSLY
EC-LPVKDTGTAEALLQNAYQAVHNLLRGVSGQALEGCAAPKVIVSNHNLLDTVENKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGKVLQSVLCYEKQ
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------MP-GSHKIAYSATTKMSD-GIDWLHSHRGMCKVDLYSPTGQQDQDRKVIC-
FVDVST--LNVEDKDSKDA-------AGSDSEGDLHLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQTPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDTEGEC
HQLH-SGNCYSVYADQLNMDYMAN-------GPQNLRLEMTASKNTNNNQSPSTPPAKSP
SNQRAVISPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 295)

RKEIKEKLEGGSK-CLHHSIY

PF05716 // ENSGT00420000029845_Domain_2 (295, 719)

PPSGD-
-KGKDSPRSAVSKIASEMAHDAVEMTSAEMR-----GTG-EECR----------------
------E-------GGRKTFLY-SELSNK-N-----KGG--DK----QVCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACMVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKRE-------TKSQSLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
TK---GKDKGKMKP---EE-CKPLTSAEKVGEHILKESLTMWN-QKQGNPGK-MA-----
------------------------S-K----------------------PC------ISN
KEEKREKISPSTDSLAKDLIVSALMLIRYHLTQQAKGKDA-FED-DCPGSTM----GYMT
Q-SAQYEKCGGNQSAKALSMKHLESHGAP---GPSTSL--KENQHLDSQKLDMSNIVLSL
IQKLLGESP-FHCEDLCE-G-EN--KRS-------EPRTNKASSMSKRPD-RGE------
--------------------------DQCQD---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNRAALAELEEQ--------------------------------
---------------------------------------------AALVSGPK-------
-R-----S------------------HDGGMSQNYQDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MSN-KVNWLQSQNGVCKVDVYSPGEGQAQDWKT---
------------------------------------------------------------
-------EAPTDPVRVLSWLRRDLEKSTAEFQDAKFKPG-ESSFG-----EELANP-GDP
R-------------KGFSVDYYNNT---TKGSPGRLHFEITHKESPS--Q----------
------A--GNKSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANCITNLVIAMARKEIEK-NDDTVKKSVQQSLYMG--D-
-EPT--SQKSLSTVASELVNATVSACVKNTETDKAS----------DKSPSMKYKSTLKI
KE----SKSPGDKPASKKSVFY-QELFESRNSGGAKEGGR-SLPAEKKMSKG--KERADD
FTGSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--STIASILLKRVLIKHAKEVVSDLI
DSFMTNLHNVTGTLMTDSDF---------LCAVKRSLFSQGSQKATDIMDAMLGKLYNMM
FANKYPETIRRAKDKSESYSLI----------SMKGM-GDPK------YRNMNFL-MKSE
AKLK---EK--MYST--CKPQKEKTCIETVGEHIIKEGLNMWHKNHQK-DCKS-------
--------------PCPQRAKSATPNE

PF05716 // ENSGT00420000029845_Domain_2 (688, 1223)

QD-------------------------------
---NVENFMCSSDSWAKDLIVSALLLIQYHLAQGGKMDPQSFLE--AATTT-----SHPA
NK--------------LSAAPNES--KYP---------HK-VCDQEQTGKKDLMSVFFNF
IRNLLSETI-FKSDNCPESKV---LIKEESVNL-------CERPVTPCSTKLCEDT----
---------------------------ETGSPFSELTKMVASQVD-----GNMSRQMVEQ
LMDSVMKLCVIIAKSCDP--SLTEL-----------------------------------
----------------------------------------GDDKCGDASRPNSALPDSLF
EC-LPVKGTGTAEALLQNAYQNIHNELRCLSGQLLEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPVLYFAGD-DEEIQKKLLQLSAAAV---EKGRSVGEVLQLVLRYEKE
RQLDEAVGNVTRLQLLDWLMLNL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFS-----GETSNS-GDP
H-------------KGFSVDYYNT----TKGTPERLHFEITHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSQVASELVNETVSACSRKAAPGKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVV
FVKKVPEHVRKARDTAESYSLI----------SMKGM-GDPR------NRNVNFA-MKSE
TKPR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------VGFQHAAFEAPNAQCK-------PSPDISFQYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLQ--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IQNLLSETI-FKRDQSSEPKVLEQPVKED-GKL-------CERPLAPSPPKLCEVD----
---------------------------ETPGALSGLTKMVVNQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASSLTLAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MNYMTN-------GPQCLHLEMAAAKNTNNNQSPSTPPAKSP
STQRTVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 323)

RKEIKEKLEGGSK-CLHHSLYPSPGD-
-KGKNSPRSAVSKIASEMAHDA

PF05716 // ENSGT00420000029845_Domain_2 (323, 1223)

VELTSAEMR-----GTG-EEGR----------------
------E-------GGRKTFLY-GELSNK-N-----KVG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKTQSLSYA----------SLKAGSQDPKCK----NQSLEFSAMKAE
MK---GKDKGKMKP---EQ-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-MP-----
------------------------S-K----------------------VC------TN-
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDT-FEE-ECPGSAT----GYMT
Q-SAQYEKSGSGQSAKALSMKHLESRGTP---GPSTSL--KENQQLDSQKLDMSNIVLML
IQKLLNESP-FNCDDLCE-G-EN--KPS-------EPRTNKAASVSKRPD-RGE------
--------------------------EQCQE---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALANNSN-YQPGGS
RC-----S------------------HDAAMSQNHQDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRVVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQMAHKEIKEKLEGKSK-CLHHSIYPSPGN-
-KERISPRTAVSKIASEMAHEAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRGSKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSGAMPQNY

PF05716 // ENSGT00420000029845_Domain_5 (1116, 1223)

QDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

---------------LKPSITSLQMSD-D

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSCRGVCKVDLYSPKEQQDQDRKVIC-
FVDVST--LNVEDKDCKDA-------AGSSSEGDLNLGNLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-FSC------KHKVGDAEGEY
HELP-SGSCFSVYADQLNMDYMAN-------GPQSLRLEMTAAKNTNNNQSPSTPPAKSP
STQRAVISPDGECSMDDLSFYVNRLSSLVIQMARKEIKEKLEGGSK-CLHHSLYPSPGN-
-KGKNSPRSAVSKIASEMAHDAVELTSAEMQ-----GTG-EECR----------------
------E-------GGRKTFPY-SELSNK-N-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSRK-PIPACVVLKRVLLNHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLSYA----------SLKAGSHDPKCK----NHSLEFSAMKAE
MK---GKDKGKMKP---EQ-YKSLTSAEKVSEHILKESLTIWN-QKQGNQGK-MA-----
------------------------D-K----------------------AC------TS-
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-FEE-ERPGSTM----GYMT
Q-SGQYEKCASGQSAKALSMKHLESRGAP---GPSTSL--KENQQLDSQNLDMSNIVLML
IQKLLSESP-FNCEDLCE-G-EN--KRS-------EPRTSRVTSVSKKPD-KGE------
--------------------------EQCQD---------NQELDFISGMKQVNCQFIDQ
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AALANNPN-YQVGSS
GC-----S------------------HDGAVSHNYQDTPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSCLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNN----TKGIPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSFYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPQERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------NRNVNFH-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDGQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CERPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSTFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPSEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMANL--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------DQAET-ES--R

PF05716 // ENSGT00420000029845_Domain_2 (867, 1067)

RS-------DFHPPKVSSLTKRG-----------
----------------------------EQE---------HQEIDFVSGIKQVNRQFVDQ
LVESVMKLCLIMAKYSN-GAGLPEAEEP--------------------------------
---------------------------------------------A

ENSGT00420000029845_Linker_2_6 (1067, 1115)

MSYR--------GS
H-------------------------CDSVVPSH

PF05716 // ENSGT00420000029845_Domain_6 (1115, 1164)

CQDAPGPEVIVNNQNS-TGNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DE------------------------------------
-------------------------------------

-----------------------MSSD-KVDWLQSQSGVCKVDVYTPGEGQPQDWKMSD-
------------------------------------------------------------
ESLSAFKEASNDPVRVLSWLRKDLEKCTSGFHDMKP-STGEMANR-----G---EHSGET
R-------------SGFTVDYYNNPGTGGRSTPGKLHLEMCHTENSS--RG---------
--SSAWTGGSNESTVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCIHQSVYMG--E-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

SPNRTLSKVASELVNETVSLCAKE-TPDKAPGSGDRATPSSRSPPNVKYKSTLKF
KETKE----CKADDKPKKSFFY-KEVFESRNAGD---GGR-------KVFGA--EPRRDD
FTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMRHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLHSVM
LKKSNEPCKKPCKDKSESLSLV----------SMKGGMNDPR------HRGMNYSSMKAE
AKLR---EK--PCTPCPSKTDKDKTCAETLGEHIIKEGLTLWHKNHQK-ETKS-------
--------------PGLQRASFATSSRSVGKPNIKL-PECHPPTTSP-GPIN---INALS
CQERQDNFLYSSDTWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGTT-----TKLA
A------------APKSNQNSEQSSLGSS---------RL-GGTHEEAEKKDLMSVFFNF
IRNLLGETI-FKCDDSSEAKAPSHHSKEEEGSF-------PEVTPPNCPPKHCGGYGGG-
---------------------------GGTGAIAGLTKMVANQLD-----GNMNGQMVEQ
LMDSVMKLCLIIAKSCDT--PLGDL-----------------------------------
----------------------------------------GDEKSGDASRPTSAFPDSFF
EC-LPVKGTGTAEALLQNAYQAIHNELRGMSIHPPEGTNTPKVIVSNHNIADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSE-KVDWLQSQNGVCKVDVYSPGDNQAQDWKT---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFCVDYYNTT---TKGTPERLHFEMTHKEIPC--QG---------
--PRAQL--GNRSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVSQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSALKI
KESTKERQGPDDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPWERKRFRG--QERPDD
FTASVSEGIMSYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFLRNLHSVTGTLMTDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVRKAQDKAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EK--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAAFEAPNTQCK-------PASDISFEYPEDIGNLSPP--PY
PPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFVE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSPEPKVPEQPVKED-RKL-------CERPLASSPPRLYEDD----
---------------------------ETPGALSGLTKMVVNQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDA--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEAVLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------ALYHPATAKMSD-D

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LNVEDKDKXXX-------XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSS-SSC------KHKVGDLEGGY
RSP--QDNCYSVYADELSMDYVAN-------NPHNLRLEMAAAKNTNNNQSPSSPPTKSP
STQRAVISPDGECSMDDLSFYVNRLSSLVIQMARKEIKEKLEGGSK-CLHHSIYASAGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GPGDLD------------------
------H-------KDRKTFLY-SELSNK-S-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA----------SLKAGSHDAKNKN---Q-SLEFSAMKAE
MMKG-GKDKGKMKP---DP-CKSLTSAEKVSEHILKESLTMWN-QKQRDK---I------
-------------------------HG----------------------KV------GTS
REDKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-LEE-PESPTTM----GYMA
Q-GTHYEKSGSGQSAKALSMKHLESRGSQ-HAGPS-----TSPKELDTQKLDMSNIVLML
IQKLLSESP-FSLDDQCE-G-ES--KRT-------ESKSKVSSSTSKRSE-KGE------
--------------------------EHFQD---------HQEFDFISGMKQVNRQFVDQ
LVESVMKLCLIMAKYSNNGAGLAELEEQ--------------------------------
---------------------------------------------AA--TEPS-FRASNS
RC-----A------------------QDAMMSHSFHDNPGPEVIVNNQSS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-EDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-D

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPTGQQDQERKVIC-
FVDVST--LNVEDKDSKDV-------GCSRSDSELNLGDLEDKEIIVIKDTEKQDLSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSS-SSC------KHRVGEMEQKC
QNYP-SDNCYSVYADQLHTDYKTK-------ESHSLRLTETASKNTNNNQSPSSPPGKSP
SNQKAVTSPDGECSMDDLSYYVNRLSSLVIQMARKEIKEKLEGGGK-CHHHSIFPQSGE-
-KGKTSPRSVLSKIASEMAHDAVEVTSAEIR-----GNG-EECK----------------
------E-------GGRKSFLY-SELANK-N-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVQSSGK-PIPACVVLKKVLLKHTKDVVSDLI
NSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKRE-------TKSQCLSYA----------SLKAGSQDPKCK----NQSLEFSAMKAE
MK---GKDKGKMKS---DT-CKSLTSAEKVGEHILKESLTM-N-QKQGNPSKM-P-----
------------------------P-------------------------K------AFS
KDDKREQISPSTDSLAKDLIVS-ITLIQYYLSQQAKGKDA-SDD-DGCSPAS----SYLT
Q-TAQYEKRGTGE-AIALSMEHLETHGFS---GASTSP--KDSQHPNCQETDMSNMVLSL
IQKIPIDGP-VRLGGSGE-G-EN--RRS-------EPGGNGSTSISTRPE-RGE------
--------------------------EQCQE---------SQDLDFISGMKQMNREFIDQ
LVESVMKLCLIMAKYNNKGAPFNELEEQ--------------------------------
---------------------------------------------ASP-SNTNFRNCPPP
KS-----C------------------HESMAPQSFQERPGPEVIVNNQCA-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MSD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDVYSPGDNHPQDWKM---
------------------------------------------------------------
-------EASTDPIRVLSWLRRDLEQSTAGFQDTRFKPG-ESSLG-----GEMANS-GDS
C-------------KGFSVDYYNTT---NRGNPGRFHFEVTHKENPG--QG---------
--SSARA--GNESSIDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVHQSLYMG--N-
-EPT-PPIKSLSKVASELVNETVSVCAKNAAPDKAPGSGDRATRSSQNSPSIKYKSTLKF
KECTREGKSPDDKPASRKSFFY-KEVFESRNAGDATEGGR-VLPGERKMFRG--QERPDD
FTASISQGIMTYANSVVSDMMISIMKTLRIQVKD--STIATILLKKVLIKHAKEVVSDLI
DSLMKNLHNVTGTLMSDTDF---------VSAVKRSLFSHGSQKALNSXXXXXXXXXXXX
XXXXXXXXXXXXXXXXX-XXXX----------XXXXX-XXXX------XXXXXXXXMISE
PNSG---KS--V--HS-AFKSEEKTCAETVGEHIIKEGLTLWHKNQQK-KCKS-------
--------------PGFQHATFTAPNKQGR-------PIPDVP----EGICNLSPP--MC
HPEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AASNT-----NLPA
TK--------------SPTVSDESTTKSP---------DA----KEETEKKDLMSIFFNF
IRNLLGETI-FKSDHSCEPKV-----KEEDSNP-------CERSTTPSPTKGCEGD----
---------------------------EAIGPLAGLTKMVANQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPDSIY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGRPPEGCMAPKVIVSNHNLCDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------MSYKIAYSDTTKMSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LSVEDKDSKDA-------AGCSSEGDLNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPLSVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGETEGSC
QKLP-SGNCYSIYADHLNMDYVKN-------EPQSLRLEMTAAKNTNNNQSPSTPPGKSP
SNQRAVNSPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 291)

RKEIKEKLENGSK-CLH

PF05716 // ENSGT00420000029845_Domain_2 (291, 1223)

HSIYPPNGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GTG-EECR----------------
------D-------GGRKTFLY-SELSNK-N-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKRE-------TKSQCLSYA----------SLKAGSHDAKCK----NQSLEFSAMKAE
MK---GKDKCKGKQ---EE-CKSLTSAEKVSEHILKESLTMWN-QKQCNQGK-MP-----
------------------------S-K----------------------TC------PH-
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKEA-CED-DCPSGSM----SYMT
Q-SAQYEKCGGSQNAKALSMKHLETRGAP---GPSTSL--KDNQHLDSQKLDMSNMVLSL
IQKLLNESP-FNCEDLCE-G-EN--KHS-------EVRTNKSTSMFKKSD-REE------
--------------------------EQGQD---------NREVDFVSGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALTDLEEQ--------------------------------
---------------------------------------------ASSSNNSNFYQASGS
RC-----S------------------HEAGISQSSQDSNGPEVIVNNQCS-TSSLQRQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

-----------------------MMSD-KVDWLQSQNGVCKVDVYTPGEGQHQDWKMSD-
------------------------------------------------------------
D--SAFKEVSNDPVRVLSWLRRDLEKCTSALQEMQQQPTGEVSNQ-----G---EPSGEN
R-------------SAFTVDYFS---SGGRNTPGKMHLEMSHTENSS--RG---------
--SSAWNS-SNESSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSESKCIHQAVYMG--E-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 872)

SPNRTLSKVATELVNETVSLCSKENSPDKAPGSGDRATLSSRSPPNLKFKSTMKF
KETKG----SKIDDKPKKSFFY-KEVFESRNAGD---GGR-------KVFGG--SGRSDD
FTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMRHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VAAVKRSLFSHGSQKATDIMDAMLGKLHSVM
LKKP-EPVKRTSKDKSESVSLV----------SLK-GINDSR------HRNMNYS-MKAE
AKFR---EK--TFAPSPS---KEKTCAETLGEHIIKEGLSLWHKNHQK-ETRS-------
--------------PGLQRATFAASSRSVGKPPCKFSPEPQPQTTSP-GPLN---TNALS
CQEKPENFPYSSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGTT-----TKMN
P------------PPKSQQNSEQSSLGSS---------RM-GGNPEEAEKKDLMSVFFNF
IRNLLGETI-FKSDDSFETKPPSHHSKE-EDSY-------PDSSPPSGPQKHGGGVSVGG
GGGGGGGGGGGGGGGGGGGGGGSGGXXXGGGAIAGLTKMVANQLD-----GNMNGQMVEQ
VMDSVMKLCLIIAKSCDT--PLGDL-----------------------------------
----------------------------------------GDEKSGDASRPTSAFPDSFF
EC-LPVKGTGTAEALLQNAYQAIHNELRGMSVHPPEGSNSAKVIVSNHNIADTIQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

---------------MMAYSGTTMMSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGSLEEKEIIVIKDAEKKDQSKME
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------EHKVGNTEGEY
HRAS-SENCYSVYADQVNIDYLMK-------RPQNLCLEMTAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSIDDLSFYVNRLCSLIIQMSHKEIKEKLEGKSK-CLHHSICPSPGN-
-KDRISPRTAASKIASEMAHEAVEMTTAEMC-----GTG-E

PF05716 // ENSGT00420000029845_Domain_2 (342, 710)

ESR----------------
------E-------GGQKSFLC-SELSNK-S-----KSG--DK----QMSQRDSKEF---
-ADSISKGLMVYVNQVASDMMVSVMKTLKVHSSGK-PVPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHSITGVLMTDSDF---------VSAVKRNLFNQWKQNATDIMEAMLKRLVSAL
IGEEKE-------TESQRLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKDKMK----SDPCKSLTSAEKVGEHILKEGLTIWN-EKQGNPCK-VA-----
------------------------T-K----------------------AC------SS-
KDEKGEKINASTDSLAKDLIISALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSAKQLESHRAP---GPSTCQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPMANKAASMSKRSD-KGE------
--------------------------EQCQE---------HQELDCISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASANKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
WQLDEAVGKVARKQLLDWLLANL--------------

---------------LRSLSFSFQMSD-D

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LNVEDKDAKCT-------IDRHTQNDILIYTFGDMLMLYIKKIHLLDKIRTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDTEGEY
HKLP-YGNCYSVYADQLNMDYVGN-------RPQSLRLEMAAAKNTNNNQSPSTPPAKSP
STQRAVTSPDGECSMDDLSFYVNRLSSLVIQMARKEIKEKLEGGSK-CLHHSIYPQTGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GTG-EEGR----------------
------E-------GGRKTFLY-SELSNK-N-----KGG--DK----QMCQKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKGKMKP---EQ-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-VS-----
------------------------G-K----------------------LC------SN-
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDS-FED-DCSGSTM----GYMA
Q-SAQYEKCGSGQSAKALSMKHLESRGAP---GPSTSL--KENQQLDSQKLDMSNIVLML
IQKLLSESP-FNCDDLSE-G-EN--KRS-------ESRTSKAASISKKPD-RGE------
--------------------------EQCQE---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSPSKRR---------------------------------------
------------------------------------------------------------
--------------------------------------------------------ESSR
LSWGWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MAD-RVDWLQSQSGVCKVDVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEKSTAGFQDSRFKPG-ESSFG-----EEVANP-GDQ
R-------------KGFCVDYYNTT---NRNNPGRLHFEMTHKENPS--PG---------
--PITQT--GNGSSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGSDNKCIHQSFYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVSSCSKNIAGDKAPGSGDRAAGSTQSP-SLRYKSTLKI
KESTKDGKCPDDKPGSKKSFFY-KEVFESRNAGDAKDGGR-SLPGDRKLFRS--PDRPDD
YTNTVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRKARDKSESYSLI----------SMKSRAGDPR------QPNMNFA-MKSE
SKMR---ES--LFSA--CKSEKDKTCAETLGEHIIKEGLTMWHKTHQK-DCKS-------
--------------PSLDSAVKQG----SP--------QPEVSFESP-DSCDLTPP--PQ
QPEVIENFMCEQDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAAST-----NFPH
AK--------------APVVHDESRLKS----------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSKRNCESKG--QNVREEEISP-------CERPITPPAPKFCEEEE---
--------------------------EEASGAFCGLSKMVANQLD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

-----------------------GRGR-THRWGHSQTGVCLLFPS-PRG-----------
---------------------------------GIHC--------------GVVWPVWME
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSV-SSC------KHKVGDTEDKN
HKLP-SENCYSIYADQLNIDYLAN-------GPQRLCLETTAAKNTNNNQSPSTPPAKSP
SNQRAVISPDGEYSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKEKLEGGSK-CLHHSIYSSPGE-
-KGKNSPQSAVRKIASEMAHDAVELTSEEMR-----GTG-EECR----------------
------E-------SGRKTFLY-SELSNK-N-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMIVSVMKTLKIHSSGK-QVPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLSYA----------SLKAGSHDTKCK----NQSLEFSAMKAE
MK---GKDKGKMKP---EQ-CKSLTSAEKVGEHILKEGLTMWN-QKQGNQGK-MP-----
------------------------G-K----------------------AC------AN-

PF05716 // ENSGT00420000029845_Domain_2 (721, 988)

MEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-LED-ECPSSTM----GYMT
Q-NAQYEKCASGQSAKALSMKRLESHEAP---GPSTSL--KENQQLDSQKLDMSNIVLTL
IQKLLSESP-FNCDDPCE-G-EN--KHS-------EPRTSKAVSMSKRPD-RRE------
--------------------------EKYQD---------NQELDSTTGMKQVNHQFIDQ
LVESVMKLCLIMAKYSNNRAALAELEEQ--------------------------------
---------------------------------------------AALVG--------GS
RY-----S------------------HDGVMPQTHQHSTGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLHEVMKFAKE
RQLDEAVGNMAKKQLLDWLLTNL--------------

---------MA-QNAWCGKCTQKEMSD-DIDWLHSRRGVCKVDLYSPKGQQDQERKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGDLNLENLEEKEIIVIKDTDKQDRSKTE
GSVCLFKQAPSDPLCVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKIGDTEGEY
SHIN-PENCYSVYADQLNMDYIGN-------GPQNLRLEMTAAKNTNNNQSPSNPANKSP
SSQRTGNASEGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 326)

RKEIKDKLEGGNK-CLHHSVFPPPGD-
-KGKISPRSAVSKIASEMAHEAVEL

PF05716 // ENSGT00420000029845_Domain_2 (326, 650)

TSAEMR-----GPG-EEGR----------------
------D-------CGRKTFLY-SELSNK-N-----KGGE-K-----QMCPRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA-------TL---KAGTNDPKCK----NQSLEFSAMKAE
MK---GKDKCRTKP---DPC-KSLTSAERVSEHILKESLNMWN-QKQGCPIKMPP-----
--------------------------K----------------------IC-------PS
KEDKREKISPSTDSLAKDLIVSALMLIQYHLTHQAKGKDP-CEE-DCPSSS------YMA
Q-SAQYEKCGGNQSAKALSMKHLETRGNC---GPSTSA--KENQQLDSQKMDMSNIVLSL
IQKLLNENT-FNCDELCE-G-ESK--RC-------EPKPSKACTSKKPE----K------
--------------------------EECPD---------NLDIDFASGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGA-LAELEEQ--------------------------------
---------------------------------------------AC-----------SS
RC------------------------QEGGVSQNCQNACGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-EDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

---------------MMACFDTTMMSD-DIDWLRSCRSVCKVDLYKPAGQQDQDRKVVC-
FVDVST--LNVEDKDCKDA-------AGSSSEGNLSLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQASSDPISVLNWLLSDLQKYALGFQHALSPST-SSC------KHKVGDTEDGC
NRSS-SGNCYSVYANQVNTDFL-N-------RPQNLQLEMAAAKNTNNNQSPSATSAKSL
STQRAVISPDGECSL

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYTNRLSSLVIQMARKEIKDKLEGRSK-CLHHSIVPSP---
---------TVSKIASEMAHEAMELTAAEMC-----GTG-EEGK----------------
------E-------GGQKSFLY-SELCNK-N-----KSG--DK----QICQRDSKEF---
-ADSISKGLMVYANQVASDMMFSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGRQNAADIMEAMLRRLVSAL
IGEKKE-------TKSQSLSYA----------TLKAGSHDPKCD----NQSLELSAMKAE
MK---GKDKCKMKS---DP-CKPLTSAEKVGEHILKEGLTMWN-QKQGN

PF05716 // ENSGT00420000029845_Domain_2 (650, 1072)

PCKIA------
------------------------T-K----------------------VC------CN-
KDEKRETISASTDSLAKDLIVSALKLIQYHLTQQARGKDT-CEE-DCPDSTT----GYMA
Q-STQYEKCGGGQSAKAFSVKHLESHGAP---GPSTCL--KENQHIDSQKMDMSNIVLML
IQKLLNES--SNCEDPCE-G-EN--KRS-------EPKVNKATSMSKRPD-KGE------
--------------------------EQCQD---------HQEFDFISGMKQVNRHFIDQ
LVESVMKLCLIMAKYSKNGAALAELEEQ--------------------------------
---------------------------------------------VASTSKPTF---RGT
RC-----T------------------HNDAMPQNYHDSPGHEVIVNNQCS-TSNLQKQLR
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
WQLDEAVGNVARKQLLDWLLTNL--------------

---------------MMAYSDTTMMSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------ASSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HRAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEMTAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 296)

AHKEIKEKLEGKSK-CLHHSICP

PF05716 // ENSGT00420000029845_Domain_2 (296, 718)

SPGN-
-KERISPRTPASKIASEMAYEAVELTAAEMR-----GTG-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSLMKTLKVHSSGK-PIPASVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNATDIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---ERDKGKMK----SDPCKSLTSAEKVGEHILKEGLTIWN-QKQGNSCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKQLESHRAP---GPSTCQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KCS-------EPRASKAASMSNRSD-KAE------
--------------------------EQCQE---------HQELDCTSGMKQANGQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASANKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQPDEAVGKVARKQLLDWLLANL--------------

---------------MIAYFGSTTMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLETLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGELDSDC
NKIP-SENCYSVYADQVNLDYLNK-------GPQNLRLEMAASKNTNNNQSPSNPATKSP
SNQRSVATPEGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSMYTS-GD-
-KGKTSPRSAVSKIASDMAHEAVELTSAEMR-----GNG-EEGR----------------
------D-------G-

PF05716 // ENSGT00420000029845_Domain_2 (377, 653)

RKTFMY-SEMSNK-N-----KCGE-KQ----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTNDPKCK----NQSLEFSAMKAE
MK---GKDKCKPKA---DPCCKSLTSAERVSEHILKESLTMWNNQKQGNQGKVTN-----
--------------------------K----------------------VC-------TS
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDP-CEE-ECPGSSM----GYMS
Q-SAQYEKCGGGQSSKSLSMKHFETRGAP---GPSTCM--KEN-QLESQKMDMSNMVLSL
IQKLLSESP-FSCDELTE-S-ESK-HCC-------DPRSNKAAPVAKRP----E------
--------------------------EQCQD---------SSELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAS-------GGS
RC-----G------------------REAAMSQNFPETPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 296)

AHKEIKEKLEGRSK-CLHHSIYP

PF05716 // ENSGT00420000029845_Domain_2 (296, 718)

SPGN-
-KDRISPRTAVSKIASEMAHEAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRASKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSSAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

------------------------MSN-K

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDKFSPEDGEAQDWKM---
------------------------------------------------------------
-------EVPSDPVRVLSWLRRDLEKSTAELQDAKFKPG-ESSFG-----KEMANS-GDP
Q-------------KSFSVDYYNTT---NKGHPGKLHFEITHKETPP--QG---------
--S---I--GNGCSVDDISFYANRLTNLVIAMARKEINEKIDGSENKCVHQSLYMG--N-
-QPT--PKQSLSKVASDLVNETVAACSNNSASDKPPGSGDKALQSSQSPPSIKYKSTLKI
KENTKEGKSPDDRPNSRKSFFY-KEVFESRNSGDARADRR-CLPEERKIFRG--LERPDD
FTSSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKQVLLKHAKDVVSDLI
DSLMRNLHSVTGTLMTDTDF---------ISAVKRSLFSHGRQKATDIMDAMMAKLYNVI
FVKKVPENVRRSKDKAENYSLI----------SMKGM-NDPK------HRNVNFATMKSE
ANFI---ER--MCPPP-PKP--EKSCVETLGEHIIKQGLTLWHKKQQK-DCKS-------
--------------PGSQCAPFTAPSKQSK-------PAPDTSAEYAQDTCNSPPM--P-
---HLENFMCDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AATHT-----SLPT
IK--------------SPAAADESTLKTP---------RFVGAEQEAAEKKDLMSVFFNF
IRNLLSETF-FKSDRSSEPKVPEHLVKED-SNQ-------CERPITPPLVKVCDGE----
---------------------------ETGGAFSGLTKMVANQLG-----GQMNGQMVDQ
LVDSVMK-CLIIAKSCDS--PLXXXXXXXXXXXXXXXXXXXXXXXX--------------
----------------------------------------XXXX-XXX---X-XXXXXXX
XX-XXX-XXXXX-XXX-XXXXXXXX-XX--XXXXX-X---XXXXXX-------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLQLSAVAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNITRLQLLDWLMVNL--------------

------------------------MPH-ELDWLNSQAGMCKVNFYSPDGPKDQQCKVVC-
FVDVGE--LV----------------------------DIEDKEVVIIKDNEQSDHVNAE
GSVCLLKPGFSKDTSVVSWLSNDLQKYALGFQHALSPSE-MPC------NANVFD----T
VS-----------------------------------------Q-NNNN----TAPSQSS
SE---------RPNPEDLAYYANKLCNLVLEMTRKEIKEKWESSGK-CTRHTITSPYSA-
--EAK

PF05716 // ENSGT00420000029845_Domain_2 (306, 729)

SPASE-----------GADVSKKPPQ-----ERS---------------------
------V--------KIEDAFT-S----E-NAQKMQDT-------------TYSDKFRMD
DGTSVSKGMMVYANQVASDMMLSFLKTMKVQKG-RRPLPACTVLKEVLLRHAKEVVSDLI
DSSMKNLHNITGALMTDSDF---------VYGLKRNLYNVGTQKTSEVMEAMVKRLFKLL
SVDDR----------PKSYTFT----------AYKAGAQSNQ-----RTQDFQFASLKRE
SHSQ---DS--RRS----------------------------------------------
------------------------------------------------------------
-------EKASMDLYAKELIVAALKQI---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

------------------------MSK-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1222)

VDWLQSPNGVCKVDVYSPSDSQPQDWKT---
------------------------------------------------------------
-------EASTDPVRVLSWLRKDLEKSTAGFQDVRFKPG-ESSVG-----GEMAQP-ADQ
H-------------MGFMMDYCNTTNKCXXXXXXXXXXXXXXXXXXX--XX---------
--XXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X-
-XXX--X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX
XXXXX-XX-XXXXX-XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXIMTYANNV--DMMTSIMKTLKI-VKD--TTIATILLKKVLIKHAKDVVSDLI
DSFMKNLHNVTGALMTDTDF---------VSAVKRA-FCQGSQKATDIMDAMMTKLYTMV
FCKKHPEALRK--DMSEAYSLF----------SMHH--RDPK------LRNVNFSSLKSE
GKFQ---EK--ISTS-PCKPP-EKSCIETLGEHLVKEGLSLWHKHHQKEK----------
-------------KPVFPCVNFDIPNKQYK-------PAPEMPLGFPLDPCDFCHPLCL-
---AQRNFMCDSESWAKDLIVSALLLIQYHLAQGGNMDAQSFLE--AASSS-----NFPP
KR--------------SPVIPDEPCVKSP---------VK-EVEQEAAEKKDLMSVFFNF
IRNLLGETI-FKGDRNAEKTDAS-SANEDEF-------RRCERPVTPCPVNSCESDESTG
----------------------------GGGLLSGLTKMVANKLE-----GHMNGQMIEH
LMDSVMKLCLIIAKSCDS--PLSDL-----------------------------------
----------------------------------------GDEKCGDANRTTSIIPECLL
EC-LPTKGTGTAEALLQNAYHAIHNELRCASGLPPEGCETPKVIVNNHNDTDTVQNKELQ
AVLQWVAASELNVPILYFAGD-DEGIQEKXXXXXXXXX---XXXXXXXXXXXXXXXXXXX
XQLDEAVGNVTRLQLLDWLMAN---------------

------------------------MSD-DIDWLCSHRGVCKVDLHNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVEDTEGEY
HTES-SENCYSVYADQVNIDYLMN-------RPQNLHLEIAAAKNTNNSQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 342)

AHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISPRTAVSKIASEMAHEAVELTAAVMR-----GTE-E

PF05716 // ENSGT00420000029845_Domain_2 (342, 538)

ESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANRVASDMMVSVMKTLKVHSSGK-PVPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLISQN
NKLSC-------------------------------------CQ----PTSM--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

---------------MIAYFGTAKMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLENLEDKEIIVIKDTEKQDQSKTE
SSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGEY
HKIP-SENCYSVYADQLNMDFLNK-------GPQSLRLEMAASKNTNNNQSPSNPAAKSP
SNQRSVATPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSMYASTGE-
-KGKTSPRSAVSKIASEMAHEAVELTSAEMR-----GNG-EECR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-K-----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTHDPKCK----NQSLEFSAMKAE
MK---GKDKCKVKA---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNPVRVPN-----
--------------------------K----------------------VC-------A

PF05716 // ENSGT00420000029845_Domain_2 (720, 987)

S
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-CEE-ECPGSSM----GYMS
Q-SAQFEKCGGGQSAKSLSMKHFESRGAP---GPSACS--KEA-QLDSQKLDMSNMVLSL
IQKLLSESP-FSCDDIPE-S-ENNKRCS-------DSRSSKAGSMSKRA----E------
--------------------------EQCPE---------NPEMDFVSGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAT---G---GGP
RC-----G------------------REGTMS-QYQEAPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MAD-RVDWLQSQNGVCKVDVYSPGEGHSQDWKM---
------------------------------------------------------------
-------EASSDPIRVLSWLRRDLEKSTAEFQDARFQPG-ETSIG-----EEIANP-GDP
R-------------KGFSVDYYNTT---TQGSPGRLHFEMTHKENPS--Q----------
------A--GNGSLV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSVRKCVHQSMYLG--D-
-EPM--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PEKSLSTVASELVKATVSACVKNSDPEKAPSSGDRASG-SQSPPHLRYKSTLKI
KESTKESECPGDKPASKKSFFY-KEVFESRNAGDAKEGGR-SLPGERKLFQG--KERPND
FTPSLSQGIMTYTNSVVSDMMVSIMKTLKIQVKD--TTIATILLKRVLIKHAKEVVSDLI
DSFMTNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYNVV
FAKKIPETLRRAKDKSESYSLV----------SMKGM-GDPK------YRNMNFS-MKSE
AKWR---EK--MHSA--CKPQKEKTCIETLGEHIIKEGLTMWHKSQHK-DCTS-------
--------------PCPEHATSAGPHEQHS-------PTSDTPFED-QDPCNLC-----L
HPEDLKNSMCDSDSWAKDLIISALLLIQHHLAQGGRMDAQSFLE--AANTT-----NFPH
NR--------------PCAAPTEPSRKYP---------HK-GCDQEQAGKKDLMSVFFNF
IRNLLSETI-FKSDCTSEHKV---RIKEEGGNQ-------YERPATPCSPKPCEDS----
---------------------------EAGGPFSELTKMVASQVD-----GHMSGQMVEQ
LMDSVIKLCVIIAKSCDS--SLVEL-----------------------------------
----------------------------------------GDDKCGDPSRPGSALPDSLY
EC-LPVKGTGTAEALLQNAYQNIHNELRDLSGQLPEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------ASSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HRAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEMTAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 296)

AHKEIKEKLEGKSK-CLHHSICP

PF05716 // ENSGT00420000029845_Domain_2 (296, 710)

SPGN-
-KERISPRTPASKIASEMAYEAVELTAAEMR-----GTG-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSLMKTLKVHSSGK-PIPASVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNATDITEAMLKRLVSAL
IGEEKE-------TKSQSPSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---ERDKGKMK----LDPCKSLTSAEKVGEHILKEGLTIWN-QKQGNSCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKQLESHRAP---GPSTCQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KCS-------EPRASKAASMSNRSD-KGE------
--------------------------EQCQE---------HQELDCTSGMKQVNGQFIDK
LVESVMKLCLIMAKYSNDGAALAEWEEQ--------------------------------
---------------------------------------------SASANKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
WQPDEAVGKVARKQLLDWLLANL--------------

---------------------------------------------------------IC-
FVDVST--LNAEDKDSKGA-------AGSSSELDFNLQTLEDKEIIVIKDTEKQDQSKME
GSVCLFKQAPFDPLIVLNWLLNDLQKYALGFQHALSPST-SSC------KHKVGDLD-NY
NK---SGNCYSVYADKLSIDHMAK-------GPQRLRLEMTAAKNTNNNQSPSTPVVKSS
NTQREVKSPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSYYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 325)

RKEIKDKLENGSK-CLHHSVYLPPGD-
-KGKSSPRSPLSKIASEMAHEAVE

PF05716 // ENSGT00420000029845_Domain_2 (325, 711)

LTSSEMR-----GTG-EENK----------------
------E-------GGQKTFMY-SELSNK-S-----KCG--EK----QMFQKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLSYA----------SLKAGSQDPKCK----NQSLEFSAMKAE
MK---GKDKGK-KS---DQ-CKSLTSAEKVGEHILKESLTMWN-QKQGNPCKMAA-----
--------------------------K----------------------LC------A-S
KDEKKENISSSTDSLAKDLIVSALRLIQYHLTQQAKGKDV-LDE-DCSGSSL----GYMA
Q-STQYEKCGSGQNARTLSMKHLESRGGP---GPSTSL--KENQQLASQKLDMSNIVLSL
IQKLLSESP-FSCDELCE-G-EN--KSS-------EPRTNKASSVARRCD-RGE------
--------------------------VQCQD---------NAELDFVSGMKQMNRQFIDQ
LVESVMKLCMIMANYS-NREAFAELEEQ--------------------------------
---------------------------------------------EAGFSNN--V----N
RC-----G------------------QEATMSRN-RDSPRPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMAKKQLLDWLLTNL--------------

------------------------MSD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDIFSPEDGQSQDWRM---
------------------------------------------------------------
-------EVPTDPVRVLSWLRRDLEKSTAEFQDAEFKPG-ESSFG-----REIANS-GDP
R-------------KSFCVDYYNTT---TKGHPGRMHFEMTHKETPP--QG---------
--S---T--GNDRSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVHQSLYMG--N-
-EPK--PNKSLSKVASDLVNETVTACSNNSVSDKAPGSGDKALESSRSPPNVKYKSTLKI
KESTKESKNPDDKPASRKSFFY-KEVFESRNAGDAKESGR-SLPGERKMFRG--VERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIRHAKEVVSDLI
DSFMRNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMMGKLYTVM
FAKKVPENVRKSKDKAESYSLV----------SMKGM-GDPK------HRNVNFATMKSE
AKFR---EK--MYCPS-PKP--EKSCVETLGEHIIKQGLTLWHKNQQK-DCKS-------
--------------PGFQRATFEAPNKQYQ-------PPPDIPAEYTQETYN-SPP--MH
HPEKFENFMYDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AATNT-----NLPA
TK--------------SPAAFDESALKTP---------HFVRGDQEAAEKKDLMSVFFNF
IRNLLSETI-FKSDHSSEPKEPEHPAKED-INQ-------CERPITPSPTKVCDGE----
---------------------------EAGGAFAGLTKMVTNQLD-----GNMNGQMVEQ
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHKELRGISGHPPEGCAAPKVVVSNQNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSE-RVDWLQSQNGVCKVDVYSPGDSQPQDWKMSD-
------------------------------------------------------------
ESLSIFKEASTDPIRVLSWLRRDLEKSTAGFQDVKFKPG-ESPLG-----GEVSDL-GDP
C-------------KGFSVDYYNAT---NKGSPGRLHFEMTHRENPI--QG---------
--PSIQL--GNGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINERIDGSENKCVHQSLYVG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1170)

-PNKSLSTVASELVNQTVSACSKNAASDRSPGSGDRASGLLQSPPNLKYKTTLKI
KESTKESKGADDKPPSRKSFFY-KEVFESRNAGDAKEGGR-SLPGERKMFRG--QERPND
FTASVSQGIMTYANSVVSDMMVSIMKTLKIHVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FAKKPPENVRKTKDRSESYSLV----------SMKGM-GDPK------NQNSNFAAMKSE
GKLR---EK--VYCPA-SKPEE-KSCVETLGEHIIKEGLTLWRKSQQK-EGRS-------
--------------PGFQRATFAAPNKQYK-------PVPDIPLDYPLDTSSLSPP--VH
HQEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFIE--AAGST-----NLPA
NK--------------SPVVSDESSPKSP---------QT-GGNQEEAEKKDLMSVFFNF
IRNLLGETI-FKSDRSSEPKVPEKPIKEECSHQ-------SERPVTPSPIKLSEGD----
---------------------------EAGGPFAGLTKMVASQLD-----GHMNGQMVEH
LMDSVMKLCLIIANSFDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPDSLY
EC-LPVKGTGTAETVLQNAYQAIHNELRGMSGQPPEGYAAPKVIVSNQSLSDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKVRR----------------------------
-------------------------------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQPQDWKMSD-
------------------------------------------------------------
ESLSIFKEASHDPIRVLSWLRRDLEKSTAGFQDIRFKPG-ESSLG-----REMVSS-GDP
R-------------KGFCVDYYNTT---SRGSPGRLHFEMSHRENPH--QG---------
--PTC-----NGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENRCVHQSVYMG--D-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASGTLQSPPNLKYKSTLKI
KESNKGGRGPDDRPSSKKSFFY-KEVFESRNAGDAKEGGR-TLPAERKMFRG--YERPDD
FTASISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATIVLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYSVI
FAKKPPETVRKTKDKSESYSLV----------SMKGM-GDPK------HRNVNFASMKSE
GKVR---ER--VCTPT-PKP--EKSCVETLGEHIIKEGLTLWHNSQQK-EGIS-------
--------------ACLQGSPFVTPKRQYK-------PVPDFPLGFPFDPCNFSLP--MQ
CPEKPENFMCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLE--AAGTS-----NLYP
TK--------------SPAVSHESSLRSP---------QV-GADPEEVEKKDLMSVFFNF
IRNLLSETI-FKSDHSCDPK----ATKEDNSPQ-------CERPVTPSPAKLNECD----
---------------------------ETGGAFAGLTKMVANKLD-----GHMNGQMVDH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPESLY
EC-LSTKGTGTAETFLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

---------------AIIYPDTTKMSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LTVEDKDSKDA-------ACSSSGGDLNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVINWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDTEGEY
HKLP-SGNCYSVYADQLNMDYMAN-------APQNLHLEMTAAKNTNNNQSPSTPPAKSP
SNQRAVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 283)

RKEIKEKLE

PF05716 // ENSGT00420000029845_Domain_2 (283, 1221)

GGSK-CLHHSIYPPTGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GTG-EEGR----------------
------E-------GGRKTFLY-SELSNK-N-----KSG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSSVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKD-------TKSQCLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKGKMKP---EQ-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-MA-----
------------------------S-K----------------------LC------PN-
REEKKEKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKEA-LEE-DSPGSTM----GYMA
Q-SAQYEKCGSGQSAKALSMKHLESSGAP---GPSTSL--KENQQLDSQELDMSNIVLML
IQKLLSESP-FNCDDLSE-G-EN--KRS-------EPRTNRGASVSKRPD-RGE------
--------------------------EQCQD---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALANNSN-YQGSSS
RC-----G------------------HDVMLSQNYQDTPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAAIYLRQGRGMGPILRTDLNFLRE
TYMDEEREDRGRKKNRDYLLAYE--------------

------------------------MSD-KVDWLQSQNGVCRVDVYPPGDSQAQGWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFRGVRFKPG-ESSFG-----GERSNS-GDP
H-------------KGFSVDYYNTT---TKGTPGRLHFEITDKENPF--QG---------
--PRAQL--VNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DAVSFYANRLTDLVIAM

ENSGT00420000029845_Linker_0_2 (273, 308)

AGKEINETIDGSENKCVHQSLYIG--N-
-EPI--S

PF05716 // ENSGT00420000029845_Domain_2 (308, 1170)

TESLSKVASELVNETISACSRNAAPDKPPSSGDRASESSQKPPKLKYKSTLKM
KESTKERQGPEDKPDSKKSFFY-KEVFESRNADYAREGGR-FFPWERNMFQG--QERADD
FTTSVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATVLLKNVLLKHAKEVVSDLI
DSFVRNLHNVTGTLMTNTDF---------VSAVKRTLFSHGSQKASDIMDAMLQKLYNVM
FADKVCEHIRKAKDEAESYSLL----------SMKGR-GDPK------KQNVNFA-MRSE
AKLR---EK--MYSE--AKSEKEKTCAETLGEHIIKEGLTLWHKN-QK-ECKS-------
--------------PGFQHAAFEAPDAQCK-------PAPDISFEYPEDTCNLGPP--QY
PPEKPENFMFNSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NK--------------SPVVPDESCLKTA---------HN-VDDQEQAEKKDLMSVFFNF
IRNLLSETI-FKRGHCSEPKVPEQLVKED-TNL-------CERPLTSSPPKPCEDD----
---------------------------ETPGAFSGLTKVVINQPD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDT--SLAEL-----------------------------------
----------------------------------------EDDKSGDASRLTSAFPDSLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGVSGQPPEGCDVPKVIVSDHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKAAEDVNVTF---EDQQKINKFARNTSRIT--
-ELKEE---IEVKKVLKIIIRRIKIFYTVAT------

------------------------LSH-QVSMRIKQNSACKTCSTVPDE--CVSIFK---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQEVRFQPG-ESSFG-----GEVFNS-GDP
H-------------KGFSVDYYTTT---TKGTPGRLHLEITHKENPF--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DEVSFDANRLTNLVIAM

ENSGT00420000029845_Linker_0_2 (273, 307)

ACREINETIDGSENKCDRQSLYMG--N-
-EPI--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKVASELVNETLSACARNAAPGKPPGSGDRASESSQNPPNLKYKSTSKT
KENTKERPGPEDKPASKKSFFC-KEVFESRNADYAREGGR-FFPWERKMCRG--QERADD
FTTSVSEGIMTYANSVVSDMMVSIMKTLKIQVKN--TTIAT----KVLLKHAKEVVSDLI
DSFMRNLHNVTGTLMTNTDF---------VSAVKRTVFSYGSQKASDIMDAMLGKLYNVM
FAEKVSEHIRKAKDKAESYSFL----------CMKGM-GDPK------KRNVNSA-MRSE
AKWR---EI--MYSE--AKSEKEKTCAETLGEHIIKEGLPLWHKN-QK-ECES-------
--------------PGFQHAAFEGPDAHCK-------PAPDISFEYPEDICNLGPP--PY
PPEKPENFMFNSDSWTKDLIVPALPLIQYHLAQGGRRNAQSFLE--AAGTP-----NFPA
NK--------------SPVVPDESCLKTA---------HN-VDDQEQAEKKNLMSVFFNF
IRNLLSETI-FKRGHCSEPKVPEQRLKED-INL-------CERPLTSSPPKPCEDD----
---------------------------ETPGAFSGLTKMVINQLD-----GNMNGQMAEH
LTASVMKLCLVIAKSCDT--SLTEL-----------------------------------
----------------------------------------EDGKSGDASRLTSAFPDSLY
EC-LPVKGTGAAEALLQNAYQAVHNELRGVSGQPPEGRAAPKGIVGNHSLIDTVQNKQLQ
AVLQWVAASKLSVPILYFADD-DEGIQEKLRQLSAAAV---DKGCSVGEVLQSVMRYEKQ
RQLNEALGNVTPLQLLDWLMANL--------------

---------------MIAYFGTAKMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLENLEDKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGEY
HKIP-SENCYSVYADQLNMDFLNK-------GPQSLRLEMAASKNTNNNQSPSNPAAKSP
SNQRSVATPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSMYASTGE-
-KGKTSPRSAVSKIASEMAHEAVELTSAEMR-----GNG-EECR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-K-----QM

PF05716 // ENSGT00420000029845_Domain_2 (410, 727)

CPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTHDPKCK----NQSLEFSAMKAE
MK---GKDKCKVKA---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNPVRVPN-----
--------------------------K----------------------VC-------AS
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-CEE-ECPGSSM----GYMS
Q-SAQFEKCGGGQSAKSLSMKHFESRGAP---GPSACS--KEA-QLDSQKLDMSNMVLSL
IQKLLSESP-FSCDDIPE-S-ENNKRCS-------DSRSSKAGSMSKRA----E------
--------------------------EQCPE---------NPEMDFVSGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAT---G---GGP
RC-----G------------------REGTMS-QYQEAPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

--------------------MARMMS--DIDWLHSCRGVCKVDLYSPIRQQDQERKVIC-
FVDVSN--LNAEDKDSKGA-------TGSSSEFNFNLQTLEDKEIVVIKDTEKKDQSKIE
GSVCLFKQAPFDPLVVLHWLLIDLQKHALGFQHALSPSA-SSC------KHKAGDID-DY
HK---TGNCYSVYADKLSIDHTAK-------GPQCLHLEMTATKNTNNNQSPSTPVVKSS
NTQKEVKSPDGECSMDDLSYYVNQLSSLVIQMACKEIKEKLESGSK-GLHHSVYQPTGE-
-KGKNSPHSPLSKIASEMAHEEVELTSSEMC-----GTG-EENQ----------------
------E-------GGQKTFLY-SELSNK-S-----KCG--EK----QMFQRDSKEF---
-ADSISKGLMVYANQEASDMIVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIMSDLF
DSCMKNLHNITRVLMTDSDF---------VSAVKSNLFNRGKQNAADLMEAMLNRLVSAL
LSEK-E-------TESQSLSYA----------TLKTGSQDPKCK----NQSLEFSSMKAE
MK---GKDKSKMKS---DQ-CKSLTSAEKVSEHILKESLTMWN-QKQGNPCKRAT-----
--------------------------K----------------------LC------A-N
KDEKKENISPSMDSLAKDLIVSALRLIQYHLIQQAKGKDT-LEE-DCPGSSL----GYVA
P-STQYEKCGGCQSTRTLSVKHLESRGTP---GPSTSL--KENQQLDCQKLDMSNIVLSL
IQKLLSESP-FSCDKLCE-G-EN--KSS-------EPRTNKASSMARRPD-R-E------
--------------------------VQCQD---------NAELDSISGMKQMNHQFIDQ
LVESVMKLCMIMANCSNNREAFAELEER--------------------------------
---------------------------------------------EAGLTNN----AGSS
RH-----G------------------QETTVLKN-QDYP

PF05716 // ENSGT00420000029845_Domain_5 (1120, 1223)

GPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMRFAKE
QQLDEAVVNMPKKQLLDWLLTNLSIPSQLEPPLPSCW

------------------------MAD-KVDWLQSQNGVCRVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFRDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNT----TKGTPERLHFEITHKENPC--QG---------
--PRAQL--GNGTSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMARKEINEKFDGSDNKCVHQSLYMG--N-
-EPP--PTKSLSKVASELVNETVSACSRNAAPGKAPGSGDRASGSSQSPPNLKYKPTLKI
KERAKERQGPEDKPASKKSFFY-KELFESRKGDYAREGGR-FFPRERKRFPG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKVQVKD--TTRVTILLKKVLLKHANDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQTAADIMDAMLRKLYSVM
FVKKVPEHVRKAQDTAESYSLI----------SVKGM-GDPK------NRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------VGFQHAAFEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKSENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVADESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IWNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CERPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVNQID-----GHMSGQMVEH
LMNSVVKLCVIIAKSCDS--SLLGDDKSGD

PF05716 // ENSGT00420000029845_Domain_4 (991, 1169)

EDRKLCERPLAPSPPKLCEDDETPGALSGL
TKMVVNQIDGHMSGQMVEHLMNSVVKLCVIIAKSCDSSLLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEECAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEK-------------------------------
-------------------------------------

------------------------MSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LNVEDKDSKDA-------AGSSSEGDLNLGNLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPST-SSC------KHKVGDTDGEY
HKIP-SGNCYSVYADQVNMDYMAN-------GPQSLRLEITAAKNTNNNQSPSTPPAKSP
SSQRAVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 275)

R

PF05716 // ENSGT00420000029845_Domain_2 (275, 1223)

KEIKEKLEGGSK-CLHHSIYPSPGD-
-KGKNSPRSPVSKIASEMAHDAVELTSAEMR-----GTG-EECK----------------
------E-------GGRKTFLY-SELSNK-N-----KSG--DK----QMCQRDSKEF---
-ADCISKGLMVYANQVASDMMVSVMKTLKIHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCLKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKCQSLSYA----------SLKAGSHDPKCK----NQSLEFSAVKAE
MK---GKDKGKMKP---EQ-CKSLTSAEKVGEHILKESLTMWN-QKQGNQGK-MP-----
------------------------G-K----------------------VC------AN-
KEEKREKISPSTDSLAKDLIVSALTLIQYHLTQQAKGKDA-CEE-DCPGSTT----GYMT
Q-SAQYEKCGSGQSAKALSMKHLESHGAP---GPSTSL--KDNQQLDSQKLDMSNIVLML
IQKLLSESP-FNCDDLCE-S-EN--KRS-------EPRTNKAASMSKKSD-RGE------
--------------------------EQCQD---------NQELDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALANNPN-YQVGGS
RC-----S------------------QDGAMSQNHQDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MSE-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDVYSPGDSQPQDWKM---
------------------------------------------------------------
-------EASTDPVRVLSWLRKDLEKTTAGFQSVRFKPG-ESSPD-----GEMTNS-EDP
Q-------------KGFSVDYYNNT---NKDNAGRFHFEMTHKENPL--PG---------
--SGAQD--DNGSTVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVHQSVYMG--D-
-EPP--PSKSLSKVASELVNETVSEYSKNTTSDKVPGSGDRVFESLQSPSNLRYKTSLKI
NE----CKGPDGKPSSKKSFFY-KEVFESHNAGDSKEGAR-SLPGERKMFKG--QERPDD
FTTSVSQKIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLGHAKEVVSDLI
DSLMKNLHNVTGTLMTDTDF---------VSAVKRSLFFHGSQKASDIMDAMLWKLYSVM
FAKKPPENIRKTKDKSESYSVV----------SMKGM-GGPK------NQKVNFATMKSE
GKLK---ER--MYSPP-CKP--EKTCVETLGEHIIKEGLSLWHKSQNK-EGKSPD-----
----------------SQC--ATTPSNQYD-------PPPDFPLEYPLDTCNFIPP--VH
HLENPENFMCDSDSWAKDLLVSALLLIQYHLAQGGSMDAQSFLE--AAGRT-----NFPT
NK--------------APVVSAETNLKSS---------HM-EGNQEETEKKDLMSVFFNF
IRNLLGETI-FKND--SEPKVPEQPIKED---L-------CERPVPPCPIKVSEGD----
---------------------------ESGGTLAGLAKMVT---------SHMNGQMIEH
LMDSVMKLCVIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPASTFPDSFY
EC-LPVKGTGTAEAVLQNAYQAIHNELRGVSGQLPEGCASTKVVVSNQNLIDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

---------------AQSYYQPATMSQ-EVDWLHSQAGVCKVDLYNPDEQKDQDRKVIC-
FVDVSS--LNVKDKDSKAN--------ISEPSNELDLGNLEEKEVIVIKDNEKHDHSKTE
GAVCLFKQGSTDELSVVSWLNNDLQKYAVGFQHALTPSD-APQ------KRKGSETFNDP
SL-----------------------------------------S-QNSD-----TSLKSA
GA---------QK-G---TYYVNKLCSLVVQMARKEITDKLEGTANKFIRQGIHGSAGE-
--GKNNTRGSVSKIASQMVNEAVEASTQDP--------QE

PF05716 // ENSGT00420000029845_Domain_2 (341, 728)

KA------------------
------ARKEDTSGSKKTSLFY-GEMSNQ-SGLKQGGKPG-DK----QMCQQAKQSGHDD
SGTSVSKGLMVYANQVASDMMFSFMKTMKVQRKDGKTTPACVVLKRVVLKHTKDVISDLI
DSTMKNLHNVTGVLMTDSDF---------VSTVKKNLFNIGSQKSTEILEAMVKRLFKAL
AGDEKQ-------SKSQSLAYT----------SVKT-GSQDS-----KSQGMQFTAMKSE
LHSQ---GK--DKD-------------------------------RGSSKCQS-------
----------------------------------------------------------TS
SKTS--EKHCSMDKYAKDLIVTALMLIQQHLLQQTNGKES-THE-SGSTSF-----GYVS
R-DSHFEKAGSSQSSKSLSMATGSRH------------SGARNDQLDSQKGDISNILLSI
IQKVLCEAG-FNIDDNAF-E-TNKNYKE---AVSSESKSSKKA-----------------
--------------------------LSKPT---------NSATDQSDNMDQMNKQFIDQ
LVESVMKLCLFMVKNNTQDLAGDMLDEQ--------------------------------
---------------------------------------------NAFGASSSK-TAALP
RK-----S------------------SQTKGNGKQLVSSGSEVIVNNQNANNSSLNKELQ
AILQWMAASHFNVPNLSFMNQ-NEGDLKKLPQLAEKAA---KKGHSVGDILQEVMRYFEK
QQMDAAVGNMPRCGLLDWLLANL--------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
SAQRAVISPDGECSIDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 321)

HKEIKEKLEGRSK-CLHHSIYPSPRN-
-KERISPQTAVSKIASEMAH

PF05716 // ENSGT00420000029845_Domain_2 (321, 1223)

EAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CGE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------KPRVSKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MARKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PRKSLSQVASELVNETVSACSRKAAPGKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVV
FVKKVPEHVRKARDTAESYSLI----------SMKGM-GDPR------NRNVNFA-MKSE
TKPR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------VGFQHAAFEAPNAQCK-------PSPDISFQYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLQ--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IQNLLSETI-FKRDQSSEPKVLEQPVKED-GKL-------CERPLAPSPPKLCEVD----
---------------------------ETPGALSGLTKMVVNQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASSLTLAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------MAD-KVNWLQSPNGVCKVDVYSPGEGQPQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDAKFKPG-ESSFG-----EELANP-GDP
R-------------KGFSVDYYNTT---TKGSPGRLHFEMSHKETPS--Q----------
------A--GNRSSVDELSLFANHLTNLVIAMARKEIDEKIDGSVKKCIHQSVYMG--D-
-DPS--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PPKSLSTVASELVNATVSECVKNANSDKAPGSGDRASE-SQSPPNLKYKSTLKI
KESTKESKCPGDKPASKKCFFY-KEVFESRNAGDAKEGGR-SLPAEKKMFKG--KERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--STIATILLKRVLIKHAKEVVSDLI
DSFMTNLHNVTGTLMTDTDF---------VSAVKRSLFSQGSQKATDIMDAMLGKLYNVV
FAKKIPETIRKAKDKSESYSLI----------STRGM-GDPK------GRNMNFS-MKSE
AKVR---EK--MYST--CKPQKEKTCIETVGEHIIKEGLTMWHKNQQK-DCKS-------
--------------PRPERAASAAPNEQGG-------PVSDPLFED-QDTCNFSPP--LC
HPEDLENSMCDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AASTT-----NFSH
GK--------------SCAAPNESNLKYP---------HQ-VCDQEQTGKKDLMSVFFNF
IRNLLSETI-FKSDRCSEPKV---RVKEEGGNQ-------CERPVTPCSTKPCEDS----
---------------------------EAGGPFSELTKMVASQVD-----GHMSGQMVEQ
LMDSVMKLCVIIAKSCDS--SLVEL-----------------------------------
----------------------------------------GDEKCGDASRPSSALPDSLY
DC-LPVKGTGTAEALLQNAYQNIHNELRCLSGQVPESCSAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

--------------------MARMMS--DIDWLHSCRGVCKVDLYSPIRQQDQERKVIC-
FVDVSN--LNAEDKDSKGA-------TGSSSEFNFNLQTLEDKEIVVIKDTEKKDQSKIE
GSVCLFKQAPFDPLVVLHWLLIDLQKHALGFQHALSPSA-SSC------KHKAGDID-DY
HK---TGNCYSVYADKLSIDHTAK-------GPQCLHLEMTATKNTNNNQSPSTPVVKSS
NTQKEVKSPDGECSMDDLSYYVNQLSSLVIQMACKEIKEKLESGSK-GLHHSVYQPTGE-
-KGKNSPHSPLSKIASEMAHEEVELTSSEMC-----GTG-EENQ----------------
------E-------GGQKTFLY-SELSNK-S-----KCG--EK----QMFQRDSKEF---
-ADSISKGLMVYANQEASDMIVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIMSDLF
DSCMKNLHNITRVLMTDSDF---------VSAVKSNLFNRGKQNAADLMEAMLNRLVSAL
LSEK-E-------TESQSLSYA----------TLKTGSQDPKCK----NQSLEFSSMKAE
MK---GKDKSKMKS---DQ-CKSLTSAEKVSEHILKESLTMWN-QKQGNPCKRAT-----
--------------------------K----------------------LC------A

PF05716 // ENSGT00420000029845_Domain_2 (719, 1068)

-N
KDEKKENISPSMDSLAKDLIVSALRLIQYHLIQQAKGKDT-LEE-DCPGSSL----GYVA
P-STQYEKCGGCQSTRTLSVKHLESRGTP---GPSTSL--KENQQLDCQKLDMSNIVLSL
IQKLLSESP-FSCDKLCE-G-EN--KSS-------EPRTNKASSMARRPD-R-E------
--------------------------VQCQD---------NAELDSISGMKQMNHQFIDQ
LVESVMKLCMIMANCSNNREAFAELEER--------------------------------
---------------------------------------------EAGLTNN----AGSS
RH-----G------------------QETTVLKN-QDYPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMRFAKE
QQLDEAVVNMPKKQLLDWLLTNLSIPSQLEPPLPSCW

------------------------MSD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDIYSPGESQPQDWKI---
------------------------------------------------------------
-------EASTDPVRVLSWLRKDLERSTAGFQDVRFKPG-ESSLG-----GEMTSS-GDQ
R-------------KGFFVDYYNTT---HEGNPGRLHFEMTHRENPP--QG---------
--PRAQL--GNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVHQSLYMG--D-
-EPT--LNKSLSKVASELVNETVSVCSKTPISDKVPGSGDRTSRSLQSPPSLKYKTTLKF
KESTKESKSPADRPASKKSFFY-KEVFESRNAGDAKEGGK-FLPGERKIFRG--QERPND
FTASVSQGIMTYANSVVSDMMVSIMKTLKVQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSFFGHGSQKATDIMDAMLSKLYNVM
FTKKFPENIRKTKDQSEIYSVV----------SMKGM-GDPK------NRNVNFASMKSE
GKLR---EN--VYCPP-HKPE-EKSCAETLGEHIIKEGLTLWHKSQNK-EGQF-------
--------------PGFQHAIFAAPNKQYK-------PVPDIPLGYPLDTCNLNPP--MH
DPEKPENF--DSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGST-----NFPA
NK--------------TPAVPDETKPKSA---------HM-EGNQEEAEKKDLMSVFFNF
IRNLLRETI-FKSDRSSERKVPEQPTKEEYSHL-------CERPVTPSPIKLSEGD----
---------------------------EAGGAFAGLTKMVANSLD-----GHMNGEMIEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPPSAFPDSLY
EC-LPVKGTGTAEALLQNAYQTIHNELRCISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDVYSPGDSQPQDWKME--
------------------------------------------------------------
--------ASTDPIRVLSWLRRDLEKSTAGFQDVKFKPG-ESSLS-----GETSDL-GDP
R-------------KGFSVDYYNTT---NKGSPGRLHFEMTHRENPI--QG---------
--PSVQL--GNGSSVDEVSFYANRLTNLVIAMARKEINERIDGSEKKCVHQSLYMG--D-
-EHT--PKKSLSMVASELVNETVSACSKNATSDKPPGSGDRASGLLQSPPNLKYKTTLKI
KESTKESKGPDDKPASKKSFFY-KEVFESHNAGDAKEGGR-SLPGERRMFRG--QERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHNVTGTLMTDSDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FAKKPPENIRKTKDKSESYSLV----------SMKGM-GDPK------NQNVNFATMKSE
GKLR---EK--MYSPA-SKPEKEKSCAETLSEHIIKEGLTFWHKNQQK-EGKS-------
--------------PGFQRATFAAPNKQYK-------PVADIPLGYPLDTCNLTPP--MH
HQEKPENFMCDSDSWAKDLIISALLLIQYHLAQGGSTDAQSFTE--AAGGA-----NLPA
NK--------------SPIVSDEPSPKSP---------QM-EGDQEEAEKKDLMSVFFNF
IRNLLGETI-FKSDHSSEPKVPEQPVKEEYSHQ-------CERPVTPSPVKLSEGD----
---------------------------EAGGTFAGLTKMVASQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GD-KSGDESRPTSAFPDSLY
EC-LPVKGTGTAETLLKNAYQAIHNELRGISGQPPEGCAAPKVIVSNHSLSDTVRNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

---------------MMSYLRSFQMSD-P

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSSRGVCKVDLYSPTERREQERKVIC-
FVDVAT--LNVEDKGSKDA-------GGSSSGGDLTLEHLEDKEIIVIKDIEKKEQSKTE
GSICLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SNC------KHKIGDTENEH
HRYP-HENCYSVYADQVNVDYTTN-------RPQSLRVEMTAAKNTNNNQSPSTPPAKSP
STQRAVMSPEGECSMDDLSFYVNRLSNLVVQMAHKEIKEKLENGNK-CFHHSIYPPSGD-
-KGKNSPRSAVSKIASEMVHDAVEITSAEMR-----GTGGEECR----------------
------E-------GGRKTFLY-SELSNK-N-----KGG--DK----QICQKDSKEF---
-ADSISKGLMVYANQVASDMMLSVMKTLKVHTSGK-PIPACVVLKKVLLKHTKDIVSDLI
DSCLKNLHNITGVLMTDSDF---------VSAVKRNLFNHGRQNATDIMEAMLKRLVSAL
LGEKKD-------SKSQSLLYA----------SLKAGSHDLKSKNQNKNQSLEFSTMKAE
MK---GKDKGKIKS---DQ-CKSLSSAERVGEHILKESLNMWN-QKQGNQGK-MI-----
------------------------S-K----------------------AC------TS-
REEKREKISSSTDSLAKDLIVSALKLIQYHLTQQAKGKDS-VED-DCPS-TT----SYMT
Q-SAQYEKSSSGQSTKALSMKHLESRGAP---GPSNCL--KEAQQADCQKLDVSNIVLTL
IQKLLSENN-FNCDDLSE-S-EN--KST-------ELRANKATSMSKRG-----------
-------------------------EEQCQE---------NPELDF-TGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGEALAELEEQ--------------------------------
---------------------------------------------GSMANNSH-YQAGGP
RC-----S------------------HDGAMPQNFEEFPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLDKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MAD-RVDWLQSQSGVCKVGVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DSSTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFG-----EEVAYP-GDQ
R-------------KGFCVDYYNTT---NKGNPGRLHFEMSHKETPP--QG---------
--LIAHV--GNGGSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGTENKCVHQSLYMG--D-
-DPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALASSQSP-GLRFTSTLKI
KESTKEGKCPDNKPGSKKSFFY-KEVFESRNAGDAKEGGR-SLPGDRKLFRC--PDRPDD
FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMKHAKEVVSDLI
DSFMKNLHSVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
CAKKYPENIRKARDKSESYSLI----------SMKSRPGDPK------LSNLNFA-MKSE
SKLK---EN--LFSA--CISEKEKTCAETLGEHIIKEGLNMWHKSQQ----NS-------
--------------PGLERATKQG----AV--------PQEVSFECP-DPCEVNPLQQPQ
PPENFENFMCESDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAAST-----NFPT
K--------------SSPVVHDEGKVKSP---------PLKICEQEQTEKKDLMSVIFNF
IRNLLSETI-FKGSRNCESKAHEQIIKEEEINLCERPLSPCERPMSPPVPKFCEDEE---
---------------------------ATGGALSGLTKMVANQLD-----GCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDEKCGDASRPSSAFPDNLY
EC-LPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MAQ-ETDWLHSQTGLCKVNLYSPEGQSDRDRKVIC-
FVDVAS--LNIK-----------------------------EKEVIVIKDKEGDHHSNSE
GAVCLFKQGSSDEVNVVSWLSNDLQKYAVGFQHALTPSG-SRK------SAYDSPA--RN
KM-----------------------------------------S-QSHD-----TTFRGS
GN---------QR-GDDLSYYVNKLCSLVVQMAHKEMKDKFESSGK-CIRQSISPRGSS-
--GRM-------------------------------------------------------
-------GDTSP

PF05716 // ENSGT00420000029845_Domain_2 (373, 600)

NDPRKASLFY-GEMNAS-NQHGYRPGGS-DR----QMCERKQP-GQ--
DDASVNKGLMVYANQVASDMMFSFMKTMKVQKG-KHPPPACVVLKKVLLKHTRDVISDLI
DSTMKNLHNVTGVLMTDSDF---------VNTVKKNLFNAGTQKSTEILEAMVKRLFKAL
AGDDKK-------SHS--LAFA----------ALKAGGHSDS-----KSQGLQFASLKSS
EEIM---KY--YEK------------------------------------QQT-------
----------------------------------------------------------DA
MSGR--MPRCGLVDYLLANL----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

---------------MMACFDTTMMSD-DIDWLRNCRSVCKVDLYKPAGQQDQDRKV---
-----------------DA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKYQSKME
GSVCLFKQASSDPVSVLNWLFSDLQKYALGFQHALSPST-SSC------KHKVGDTEGEC
NRSS-SGNCYSVYANQVNIDLL-N-------RPQNLQLEMAATKNTNNNQSTSATSAKSL
STQRAVISPDGECSL

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNQLSSLVIQMARKEIKDKLEGRSK-CLHHSIVPSP---
---------AVSKTASEIAHEAMELTAAEMC-----GTG-EECK----------------
------E-------GGQKSFLY-SELSNK-N-----KSG--DK----QIYQRDSKEF---
-ADSISKGLTVYANRVASDMMFSVMKTLKVHSSRK-PIPACVVLKRVLLNHAKEIVSDLI
DSCMKKLHNITGVLMADSDF---------VSAVKRNLFNHGKQNAADIMEAMLRHLVSAL
IGEKKE-------TKSQHLSYA----------TLKAGSRDPKCN----NKSLELSAMKAE
MK---GKDKCKMKS---DS-CKSLTSAEKVGEHILKEGLTMWN-QKQGNPCKMV------
------------------------T-K----------------------VC------CN-
KDEKRETISASTDSLAKDLIVSSLKLIQYHLTQQARGKDT-CEE-DCPDSTT----GYMA
Q-STQYEKCGGGQSAKALSVKHLEFHGAP---GPSTCQ--KENQRIGSQKMDTSNIVLKL
IQKLLNES--SNCEDLCE-G-EN--KHS-------EPKVNKATSMSKRPD-EGE------
--------------------------EQCQD---------HQEFDFISGMKQVNWHFIGQ
LVESVVKLCL-MAEYSKNGAALAESEGE--------------------------------
---------------------------------------------AASTSKPTF---RGT
RC----

PF05716 // ENSGT00420000029845_Domain_5 (1087, 1223)

-I------------------HNDAMPQNYQDPPGHEVIVNNQCS-TNSFQKQLR
AVLQWIAASQFDVPMLYFMGD-DDGQLEKLPQVSAKAA---EKGYSVGGLLQEVIKFAKE
QQLDEAVGTMAKKQLLDWLLTNL--------------

------------------------MSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELDLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGDY
HKIP-SENCYSVYADQLNMDFLNK-------GPQSLRLEMAASKNTNNNQSPSNPAAKSP
SNQRSVATSDAECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSIYASPGE-
-KGKTSPRSAVSKIASEMAHEAVELTSAEMR-----GNG-EECR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-K-----QM

PF05716 // ENSGT00420000029845_Domain_2 (410, 537)

CPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSDR
HTSCLR-------FWICDMTLTQETGTYGDVSSLRPVGPLPKKY-QITQTNSAFSTAP--
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

---------------MISIC-YTAMSD-DINWLHSCRGMCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------SGSRTEGELNLENLEEREIIVIKDTENQEHFKME
VSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KYKVGDIEGEY
HKIP-SEKCFSAYTDQLNMDYMNK-------RPQSLHLEMTAAKNTN-NRSPSNPAAKSP
RNQRSVVTPDGECSMDNLSFYVNRLYSLVMQMAREEIKGKLEGGSK-CLHHSMSASNGD-
-KGKNSPHSAVRKTASEMAHEAVELTSAEMH-----GTG-EECR----------------
------D-------GGQKTFLY-SELSNK-N-----KCGE-K-----QMCPKDSKEF---
-ADSISKGLMVYANQVTSDIMIPVMKTLKVQSCGK-PILPCVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQKAADIMEAMLKHLVSAL
LGEKKE-------TKSQSLAY-------ATL---KTGTHDLKS----KNQSLEFSAMKAD
MK---GKDKCKVKT---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNQGRMIN-----
--------------------------K----------------------VC-------AS
KDDKREKISPSTDLLAKDLIVSALKLIQYHLTQQTKGKDL-CED-DWPGSSM----GYMS
Q-STQYEKCGGGQSAKSLSMKPFETHGAP---GPSACV--KENQQLDSQKLDMSNMVLSL
IPKLLSESP-FSCDELCE-R-ENK-RHF-------EPRTSKVAPMSKIP----E------
--------------------------EQCPD---------NPELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELKEQ--------------------------------
---------------------------------------------AALASNPNF---SGS
RC-----G------------------PKGA

PF05716 // ENSGT00420000029845_Domain_5 (1111, 1223)

MSQNYQDSPVPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKTA---EKGYSVGALLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MS--DIDWLHSCRGVCKVDLYSPVRQQDQERKVIC-
FVDVST--LNAEDKDSKGA-------ADSSSEFKFNLQTLEDKEVIVIKDTEKQEQSKME
GSVCLFKQAPFDPLIVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDTD-SC
PK---TGNCYSVYADKLSIDHSAK-------GPQRFRLEMTAAKNTNNNQSPSTPVVKSS
NTQREVKSPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSYYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 324)

RKEIKEKLEGGSK-CLHQSAYQSAGE-
-KGKSSPRSPLSKIASEMAHEAV

PF05716 // ENSGT00420000029845_Domain_2 (324, 687)

ELTSSEMR-----GTG-EENK----------------
------E-------GGQKTFLY-SELSNK-S-----KCG--EK----QMFQKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VTAVKRNLFNHGRQNAADIMEAMLKRLVNAL
LGEKKE-------TKSQSLSYA----------TLKAGSQDPKCK----NQSVEFSAMKAE
MK---GKDKGKMKS---DP-CKSLTSAEKVSEHILKESLTMWN-QKQGNPCKMVT-----
--------------------------K----------------------LC------A-S
KDEKKENLSPSTDSLAKDLIVSALRLIQYHLTQQARGKDV-LED-DCPGSSL----GYVA
Q-NTQYEKCGGGQSARTLSVKHLESRGGP---GPSSCL--KESQQLACQKLDVSNIVLSL
IQKLLSDCP-FPCDELCE-G-EN--RCS-------EARTSKASSMARRPD-REE------
--------------------------VQCQD---------NAEPDFISGIKQMNRQFIDQ
LVESVMKLCMIMANCS-NRETFAELEER--------------------------------
---------------------------------------------EACLGNN--LNMASS
RC-----C------------------QEATVSRK-RDCPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMAKKQLLDWLLTNL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQAQDWKMSD-
------------------------------------------------------------
ESLSIFKEASTDPIRVLSWLRRDLEKSTAGFQDVRFKPG-ESSFG-----GEMVNW-TDP
H-------------KGFCVDYYNTT---AKGNPGRLHFEMTHRENPS--QG---------
--PSAQV--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINERIDGFEKKCVHQSVYLG--E-
-EPA--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PNKSLSKVASELVNETVSTCSNNATSDKTPGSGDRASGSSQNAPNLKYKSTLKI
KESTKGSRGPDDRPASKKSFFY-KEVFESRNAGDATEGGR-SLPAERKMFRG--QERPDD
FTTCVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLIRHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVV
FAKKPPDTGSRAKDKSERYSLV----------SVKEM-GDPK------NRNINFASMKSE
GKLR---EK--ICSHS-PKPETEKSCAETLGEHIIKEGLTLWHKSQQK-EGKS-------
--------------PAFQCLPFAAPNKQYK-------PAPDILLGFPFDPCNLSPP--LQ
HLEKPENFMCDSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAAST-----NLQA
NK--------------SPAVSDESSLKPP---------HV-GGDQEEAEKKDLMSVFFNF
IRNLLRETI-FKSNRSSDPK----PTKEEDSPQ-------CERPVTPSPIKFSEGD----
---------------------------EAGGTFAGLTKMVANQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLGEL-----------------------------------
----------------------------------------GDDKSGDASRPVSAFPENLY
EC-LPTKGTGTAETLLQNAYQAIHNELRGMSGQPLEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MAD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKV---
------------------------------------------------------------
-------QAPSDAISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDAVGPY
CR----------------------------------SYEMAAAKNTNNNQSPSSPSAKSP
SFQRAHVNPEGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMARKEIKEKLEGGGK-CLHQAIYASTSGE
RGNKNGPRSAVSKIASEMAHDAVEMTSAEIR-----GPGEQPGD----------------
------EQPREEGGVPRKTFLY-GEVSRK-GG----PKGG-DK----QMCQSGSKDF---
-ADSISKGIMVYANQVASDMMLSVMKTLRVQSSGKSPIPACVVLKKVLLKHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFKQGKQNAADIMEAMLKRLVSAL
LGEKKD------QSKSGSLAYA----------SLKAGSHDSRSK----NQSLDYTVMKAE
MK---GKDKDKGKS---GQ-TKSLTSAEKVGEHILKESLTMWNQKQQGQQGQQAK-----
------------------------GQG----------------------KS------CYG
REEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAK---------------------YSA
Q-GAHYEKSGSNQSTKALSMKHMEATRNGPHAGPSNQP--SKEAQMDTHKLDISNLVLAV
IQKLLSDNFNI--DGDQAET-ES--RRS-------DFHPPKVSSLTKRG-----------
----------------------------EQE---------HQEIDFVSGIKQVNRQFVDQ
LVESVMKLCLIMAKYSN-GAGLPEAEEP--------------------------------
---------------------------------------------AMSYR--------GS
H-------------------------CDSVVPSHC

PF05716 // ENSGT00420000029845_Domain_5 (1116, 1223)

QDAPGPEVIVNNQNS-TGNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DEGLLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDDAVGNITRKQLLDWLLANL--------------

------------------------MAD-RVDWLQSQNGVCKVDVYSPGDFQHQDWKM---
------------------------------------------------------------
-------DASTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFG-----EEVAIP-GDQ
R-------------KGFCVDYYNTT---NRGSPGKLHFEMTHKENPP--PG---------
--PIAHA--GNGSSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGSENKCVHQSFFMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVSACSKNIAGDKAPGSGDRALGSVQSP-SLRYKSTLKI
KESTKDGKCPDDKPGSKKSFFY-KEVFESRNAGDAKDGGR-SLPGERKLFRG--QDRPDD
YTNSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
VAKKFPENIRKARDKSESYSLI----------SMKSRPGDPQ------QPNMNFE-MKSE
AKLR---ES--LFSA--CMPEKEKSCAETLGEHIIKEGLTMWHKTHQK-DCKP-------
--------------PGTDFAAKLC----HP--------RPEVSVEVP-DPCDLSPP--PQ
QPEPFEKFMCESDSWAKDLIVSALLLIQYHLAQGGRMDPQSFLE--AAATT-----NFPG
NK--------------PQAVHDESRLKS----------PHKMCDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSKRNSESKA--QGVKEEEINQ-------CERPVTPPE-----EEE---
--------------------------EESDGALSGLTKMVANQLD-----GCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTIQNKQLQ
AVLQWVAASELNVPILYFAGD-DEEIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSE-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNTT---TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVYQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKI
KESTKERQSPDDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMRNLHSVTGTLMTDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVRKAQDKAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EK--MYSE--PKSE-EDTCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAAFEAPNTQCK-------PASDISFEYPEDIGNLGPP--PY
PPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDVQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRSLLSETI-FKRDQSPEPKVPEQPVKED-RKL-------CERPLASSPPRLHEDD----
---------------------------ETPGALSGLTKVVVNQID-----SHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDGQPQDWRM---
------------------------------------------------------------
-------EAPVDPVRVLSWLRRDLEKSTAGFQDLRFKPG-ESSVG-----GETVNS-GDP
R-------------KGFCVDYYNTT---NKGSPGRLHFEITHKENPC--QG---------
--HRVPF--GGGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--D-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKTLSKVASDLVSETVSACSKTAVSDKAPGSGDRASGS-----NLKYKATLKM
KESTKECKSPNDKPASKKSFFY-KEVFEARNAGDAREGRK-FIPGERKMFQG--QERPDD
FTASISEGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLLKHAKDVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSFFCHGSQKATDIMDAMLNKLYNVM
FAKKVPEIIRKSKDKSESYSLI----------SMKGI-GDPK------HRNMNFA-MKSE
AKLR---EK--MYSPV-PKPEKPKTCAETLGEHIIKEGLSLWHKSQQK-ECKS-------
--------------PGFQRATCEALPKPCK-------PAPEFPFECLPDPCNISPP--LC
CPERLENFMYDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAATT-----NFPA
NK--------------LPVVPDESCLRSS---------HV-VCDKEQSEKKDLMSVFFNF
IRNLLGETI-FKNDQ--------HPVNEEDSNR-------CERPATPSPIKLCEEE----
---------------------------EAGGTFSGLTKMVVSQLD-----GQMGGKMVDH
LVDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKCGDASRPPSAFADNLY
EC-LPAKGTGTAEALLQNAYQAIHNELKGISGQPPEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------MARMVKMS--DIDWLNSCRGVCKVDFYSPIRQQDQERKVIC-
FVDVST--LNAEEKDSKGA-------TGSCSEFNFNLQTLEDKEIIVIKDTEKQDQSKME
GSVCLFKQAPFDPLIVLNWLLNDLQKYALGFQHALSPSA-SSC------KYKLGDKD-AY
PQ---TGNCYSVYADKLSIDHTAK-------EPQRFHLEMMAAKNTNNNQSPSTPVVNSP
NTKRKVKFSDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSYYVNRLSSLVIQMAHKEIKKKLENRNK-CLHHSVYQPTGD-
-KGQNSPRSPLSKISSEMAHEAVELTSSEMQ-----DTG-EENK----------------
------E-------GSQKTFRY-SELSNK-S-----KCG--EK----QMFQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKMHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGILMSDSDF---------VSAVKRNLFNHGKQNAANIMEAMLKRLVSAL
LGERKK-------TKSQSLSYA----------TLKAGSQDPKCK----NQSLEFSTMKAE
MK---EKDKCKMKS---DQ-CKSLTSAEKVSEHILKESLTMCN-QKQGNP

PF05716 // ENSGT00420000029845_Domain_2 (651, 1071)

CKMAT-----
--------------------------K----------------------LC------T-S
KDEKKGNKSPSTDSLAKDLIVSALRLIQYHLTQQAKGKDT-LEE-DGPGSSL----GYVT
Q-STQYEKCGGGQSAKTLSKKHLESRGTP---GPSTSI--KENQQLDCQKLDMSNIVLSL
IQKLLSDSP-FSCDELCD-G-EN--KRS-------DPRTNKTSSMARRPD-R-E------
--------------------------VPCQD---------NAEVDFISGMKQMNRQFINQ
LVESVMKLCMIIANYSNNREAFAELEEQ--------------------------------
---------------------------------------------EAGLANS--VNIGSS
RC-----G------------------QETTVSRN-QDSPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLIQEVMKFAKE
QQRDEEVGNMAKKQLLDWLLTNL--------------

---------------EIAYSSTTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXXX---XXXXXXXXXX-------XXXXXXXXXXXXXXXXXX

PF05716 // ENSGT00420000029845_Domain_2 (105, 1223)

XXXXXXXXXXXXXXTE
GSVCLFKQASSNPVSVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDIEGEG
HKIS-SGNCYSVYADQLNMDYVAN-------GPQSLRLEKTASKNTNNNQSPSSPPAKSP
NNQRSVISPDGECSMDDLSYYVNRLSSLVIQMARKEIKEKLEGRSK-CFHHSIYPHTGD-
-KGKSSPHSAVSKIASEMAHDAVEVTSAEMR-----GTK-EECR----------------
------D--------GRKTLLY-SELSNK-N-----RGG--DK----QMCQRDSKEF---
-ADSISKEFTVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMMDADF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA----------ALKAGSLDPKCK----NQSLEFSAMKAE
MK---GKDKSKIKP---DE-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGKVAS-----
--------------------------K----------------------AC------T-S
KDEKREKISPSTDSLAKDLIVSALKLIQYHLTQQ-KGKDA-FDD-PTT--------GYMT
Q-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX
XXXXXXXXX-XXXXXXXX-X-XX--XXX-------XXXXXXXXXXXXXXX-XXX------
--------------------------XXXXX---------XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------------------
----------------------------------------------XXXXXXX-----XX
XX-----X------------------XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAIGNMARKQLLDWLLTNL--------------

------------------------MSE-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1173)

VDWLQSQNGVCKVDVYSPGDNQIQDWKM---
------------------------------------------------------------
-------EVSKDPVRVLSWLRRDLEKSTAGFQDVRFKPG-ESTLA-----EGMANA-GDS
Q-------------RGFYMDAYNTT---SKGIPGKLHFEVTHKEIPS--QG---------
--PGALP--GNGKSVDEVSFYANRLTNLVIAMARKEINEKIDGSEKKCIHQSLYMG--D-
-EPA--PTKSLSKVASELVNETVSACSRSGDSDKAPGSGDRGSGSSN-LPSLKKKSTLKI
KETTRESKGSDDKPVSRKSFFY-KEVFESRNAGDAREGGR-L-LGERRLFRG--QERPDD
FTTSISQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSFFCHGSQKATDIMDAMLGKLYTVM
FTKKFPENLRKTKDKRESYSVM----------STKGM-GDPR------HCNVNFA-MRSE
AKLR---EK--MYPA--PKPE-KKSCAETLGEHIIKEGLSMWHKSHRK-ECTS-------
--------------PGFERAAFLDPNKQCK-------LTPDIPFEITQENCCLSPL--LQ
HPENPENFMCESDSWAKDLIVSALLLIQYHLAQGGKMDPQSFLE--AASTT-----NLPT
KK--------------CAVIPDEPSFRIP---------HV-VCDQEQAE-KELMSVFFNF
IN--LGETF-FKSEQNXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----
-----------------------------XXXXXXXXXXXXXXXX-----XXX-XXXXXX
XXXXXXXXXXXXXXXXXX--XXXXXX----------------------------------
------------------XX----X-XXX-----------XXXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXX-XXXXXXX------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLQL---------------------------
-------------------------------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNN----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------HRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----SFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CDRPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------MIAYCGTTKMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVED-DSKGA-------AGPRSEGELNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGDY
HKIP-SENCYSVYADQVNLDYLNK-------GPQNLRLEMAASKNTNNNQSPSNPATKSP
SNQRSVATPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSYYVNRLSSLVIQMARKEIKDKLEGGNK-CLHHSMYTS-GE-
-KGKTSPRSAVSKIASEMAHEAVELTSSEMR-----GNG-EEGR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-KQ----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTHDPKCK----NQSLEFSAMKAE
MK---GKDKGKTKG---DPCCKSLTSAERVSEHILKESLTMWNNQKQGTQGRVPN-----
--------------------------K----------------------VC-------

PF05716 // ENSGT00420000029845_Domain_2 (719, 987)

PS
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDP-CEE-ECPGSSM----GYMS
Q-SAQYEKSGGGQSSKSLSMKHFESRGAP---GPSTCA--KEN-QLESQKMDMSNMVLSL
IQKLLSESP-FSCDELSE-S-ENK-RCC-------DSRSKQAAPVAKRP----E------
--------------------------DQSQD---------STEMDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALAS-------X--
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

------------------------MSE-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-ADP
H-------------KGFSVDYYNTT---TKGTPESLHFEMTHKEIPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVYQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKNLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTVKI
KESTQERQGPDDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFLRNLHSVTGTLMTDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVRKAQDKAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---AK--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECQS-------
--------------LGFQHAAFEAPNTQCK-------PASDISFEYPEDIGNLSPP--PY
PPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKHDQSPEPKVPEQPVKED-RKL-------CERPLASSPPRLYEGD----
---------------------------ETPGALSGLTKMVVNQID-----GRMSGQMVEH
LMNSVMKLCVIIAKSCDA--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEAVLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------MSD-DIDWLHSRRGVCKVDLYSPRGQQDQDRKVIC-
FVDVST--LSMEDKDSKDA-------AGCSSEGDLNLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPLSVFNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGETEGNC
QKLS-SGNCYSIYANHLNMDCVNN-------EPQSLRLEMTAAKNTNNNQSPSTPPGKSP
SNQRAVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 275)

R

PF05716 // ENSGT00420000029845_Domain_2 (275, 1223)

KEIKEKLENGSK-CLHHSIYPPSGD-
-KGKNSPRSAVSKIASEMAHDAVEVTSAEMR-----GTG-EECR----------------
------D-------GGRKTFLY-SELSNK-N-----KGG--DK----QMCQRDSKDF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQCLSYT----------SLKAGSHDAKCK----NQSLEFSSVKAE
MK---GKDKCKVKQ---EE-CKSLTSAEKVSEHILKESLTMWN-QKQCNQGK-MP-----
------------------------S-K----------------------TC------PH-
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKEA-CED-DCPPGTT----SYMT
Q-SAQYEKCGGSQSAKALSMKHLETRGAP---GPSTSM--KDNQHLDSQKLDMSNMVLSL
IQKLLNESP-FNCEDLCE-G-EN--KHS-------EIRTNKSTSIFKKSD-REE------
--------------------------EQGQD---------NREVDFVGGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNEAALTDLEEQ--------------------------------
---------------------------------------------ASSSNNSNFYQTSGP
RS-----S------------------YEAGMSQSYQDSHGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-KVDWLQSQNGVCKVDVYSPGDSQLQDWKMSD-
------------------------------------------------------------
ECLSIFKEASTDPIRVLSWLRRDLEKSTAGFQDVRFKPG-ESSFN-----GEMSNL-GDP
R-------------KGFSVNYYNST---TKGSPGRLHFEMSHRENPV--QG---------
--PSVQL--GNGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINERIDGSENRCIHQSLYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PNKSLSKVASELVNETVSACSKNTTSEKAPGSGDRASGLLQSPPNLKYKTTLKI
KESTKKSKGPDDKPPSKKSFFY-KEVFESRNAGDAKEGGR-SLPGERKVFRG--QERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHNVTGTLMTDSDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FAKKPPENLRKTKDKSESYSLV----------SMKGM-CDPK------NQNTNFASMKSE
GKLK---EK--MYSPA-SKPEKEKSCAETLGEHIIKEGLTFWHTNQQK-EGKS-------
--------------PGFQRATFAAPNKQYK-------PVPDIPLGYPLDTCNLSPP--MH
HREKPENFICDSDSWAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGST-----NLPA
NK--------------SPVVSDESSLKSP---------QM-GGDQEEAEKKDLMSVFFNF
IRNLLSETI-FKSDRSSEPKVPEQPIKEEYSHQ-------CERPITPSPIKLSEGD----
---------------------------ETGGTFAGLTKMVANQLD-----GHMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPDSLY
EC-LPVKGTGTAETLLQNAYQAIHNELRGISGQPPEGCTAPKVIVSNHSLSDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYTPGDSQAQDWKMSD-
------------------------------------------------------------
ESLSIFKEASTDPIRVLSWLRRDLEKSTAGFQDVRFKPG-ESSLG-----GEMSNPGGDP
R-------------SGFSVDYYNTT---TKGSPGRLHFEMMHRENPV--QG---------
--PSVPL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINERIDGSENKCVHQSLYIG--D-
-EPI--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PNKSLSKVASDLVNKTVSACSKNATSDKTPGSGDRTSGLLRSPPHLKYKTTLKM
KESTKESKGPDDKPASKKSFFY-KEVFESRNAGDAKEGGR--LSGERKMFRG--QERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHSVTGTLMTDSDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYTVM
FAKKPSEIIRKTKDKSESYSLV----------SMKGM-GDPK------KQNVNFASMKSE
GKLR---EK--MYSPA-SKPEK-KTCAETLGEHIIKEGLSFWHKNQQK-EGKS-------
--------------PGFQQVTFAAPNKQYK-------PVPDIPLGYPLDTCNLSPP--MQ
CREKPENFMCDSDSLAKDLIVSALLLIQYHLAQGGSMDAQSFLE--AAGST-----NLPA
NK--------------SPEVPDESSLKSP---------HM-GGDQDEAEKKDLKSVFFNF
IRNLLGETI-FKSDRSSEPKVPEQPVKEEYNYQ-------CERPVTPSSIKLSEGD----
---------------------------EAGGTFAGLTKMVVNQLD-----GHMNGQMVEY
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPDNLY
EC-LPVKGTGTAEAVLQNAYQAIHNELRGISGQPPEGYAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQPQDWKMSD-
------------------------------------------------------------
ESLSIFKEASHDPIRVLSWLRRDLEKSTAGFQDVRFKPG-ESSLG-----REMVSS-GDP
R-------------KGFCVDYYNTT---SRGSPGRLHFEMSHRENPH--QG---------
--PSTHP--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENRCVHQSVYMG--D-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PNKSLSKVASELVNETVTACSKNTPSNKAPGSGDRASGTLQSPPNLKYKSTLKI
KESSKGARCPEDRPSSKKSFFY-KEVFESRNAGDAKEGGR-ALPAERKMFRG--HERPDD
FTTSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATIVLKRVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYSVI
FAKKTPETVRKTKDKSESYSLV----------SMKGM-GDPK------HRNVNFASMKTE
GKVR---EK--VCTPT-PKP--EKSCVETVGEHIIKEGLTLWHNSQQK-EGIP-------
--------------SCLQGSPFVTPKRQCK-------PGPDFPLAFPFDPCHFSLP--MQ
CPEKPENFLCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLE--AAGTS-----NLYP
MK--------------SPAVSHESSLRSP---------RV-GADPEEVEKKDLMSVFFNF
IRNLLSETI-FKSDHSCDSK----AAKED-GPQ-------YERPATPSPAKLNECD----
---------------------------EPGGAFAGLTKMVANKLD-----SHMNGQMVDH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSAFPESLY
EC-LSTKGTGTAETLLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------MACKEINEKIDGSVKKCIHQSMYVG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PKKSLTTVASELVNETVSACVKNTDPDKTPGSGDRASQ-SQSPPNLKYRSIVKI
KESTKESKCPGDKPASKKSFFH-KEMIESQILGDAKEGGR-SLPGERKLFQG--KERPND
FTPSVSQGIMTYANSVVSDM-VSIMKTLKIQMKD--TTIATNLLKRVLIKHAKEVVSDLI
DSFMASLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLRKLYNVV
FAKKIPETIRRAKDKSESYSLI----------SMKGT-GDPK------CRNMNFS-MKSE
AKLR---EK--MYST--CKPQKEKTCMETLGEHIIKEGLTMWHKSYHK-ECKS-------
--------------PGPKHATSAAPKEQDS-------PTPDIPFED-QDPCNLTPT--LH
HPEDLESSMCDSDSWAKDLLVSALLLIQYHLAQGGRMNAQSFLE--AASTT-----NFPH
NK--------------PCAAPNESNLKYP---------HK-GCDQEQSGKKDLMSVFFNF
IQNLLSETI-FKSDHTSEHKV---QVKEEGGSQ-------YERPVTPCSAKPCEDS----
---------------------------EAGGPFSELTKMFTSHVD-----GHMSGQMVEQ
LTDSVMKLCVIIAKSCDS--SMVEL-----------------------------------
----------------------------------------GDDKCADASRSGSALPESLY
EC-LPVKGTGTAEAVLQNAYQNIHSELRGLSGQLPEGCAAPKVIVSNHNLTDTIQNKQLQ
AVLQWIAASELNVPILYFAGDDDEGIQEKLLQLSAAAV---EKGRSVGEVLRLVLRYEKE
RQLDEAVGNVTRMQLLDWLMANL--------------

---------------IIDYSDTTMMSD-DIDWLHSRRGVCKVDLYSPVGQRDQDRKVIC-
FVDVST--LNVEDKDCKDA-------TGSSSDGDLSLGNLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVFNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGETKDEE
HQMH-SGNCYSVYADQLNLNYLTN-------EPQSLRVEMTAAKNTNNNQSPSSPPAKSS
SGQRAVISPDGECCMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSYYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 285)

RKEIKDKLEGG

PF05716 // ENSGT00420000029845_Domain_2 (285, 1223)

SK-CLHHSMYPPTGD-
-KGKNSPRSAVSKIASEMVHDAMEVSSSEMR-----GPG-EDCK----------------
------E-------GGRKTFLY-SELSNK-N-----KCG--EK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHS-GK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKRE-------TKSQSLSYA----------SLKAGSQDPKCK----NQSLEFSAVKAE
MK---GKDKCKAKT---DP-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-VA-----
------------------------C-A----------------------KA------CAN
KEEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKCKDT-CEE-ECPSSSV----NYVA
Q-STQFEKCGGAQTAKAVSMKHVESRGNP---APSTSAAAKETPQPDCQKLDMSNIVLTL
IQKLLNESP-FSCEELCE-G-EN--KRS-------EPKIAKPSCMSKRSD-RVE------
-------------------------EQQCQE---------NQDLDFLSGMKQVNRQFIDQ
LVESVMKLCLIMAKYSSNGAALAELEEQ--------------------------------
---------------------------------------------AALAGNSNF---SGL
KC-----G------------------HDGAMSQGF-DTSGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MTE-NVDWLQSQNGLCKVDRYTPGGEEEQNWTKALW
LADVSL--ISMKKFSSQRAHGNI---------QKQKSGSLTE-EIIKYIMHPKEVKNTFT
DSAKFFKQAASDPLKVLSWLRKDLERCALGIQDVLKSTG-KQKACESSREPSIGGQSI-Q
MRNAPSPGGFSVYDEQLSMDIRSN------SGSPDFHMEMKTTSSQK---EPK-------
DEESQQTSADAKQGVDEVSFYVNRLSNLVIAMARKEINDKTDGADK-CIHKSLFASLGEP
--GHKSIGV

PF05716 // ENSGT00420000029845_Domain_2 (310, 1072)

GTNESKNNPSENTTHINVKET------------------------------
-------KYEDNPSSKKKTFFY-KEVDEQ-SSNRNE-----------QSHERRSDEF---
-TNTLSKGILVYANNVVSDMMVSVMKTMKVQVND--SSIACVVLKKVILKHSKEVVSDLI
DSCMKNLHNVTGTLMTDSDF---------VSAVKRSLFSQGSHKAAEIVQAMLNRLHSTL
IVQKPAGD----KSQSQSLAYA----------SVKTGSRSADAK----AQNLRFSSAKTE
TFTK---EK-----------EKEMTCAETVGNHIIKHGLTLWHQNQQK-CNKCSK-----
------------------------S-------------------------Q------PSA
KEEIQNIAKMSGDAWAKDLIVTALLLIQYHLIQQENAGKG-TSEGDKTNKAGTTAFGFLS
HES---HDKGGGSSFRPSSAKHQDSSKQND---ES--DSQKSECKKRDPENDMSSIILML
IRKLINETGCK-IEDQQGNSMTDETNRN----PGKNS---EGHALSEV------------
-------------------------EQSCEEAISGLTKMITDQFDISGKE-EGNGQFIDS
LVDTVTKLCLMIAKYSNPESALAEIRER--------------------------------
---------------------------------------------EEGTGSMDS----KG
T------G------------------TEAGLGSGEDSASGRKVVVMNQNPSESVHNKQLQ
ALLQWVAASQTNVPVLYFLDE-DDEFLNKLQQLSSIAV---EKGYSVGEVIQAVLKYEKE
KQLGEALGNMVRLPVLDWLLNNL--------------

---------------EIAYSDTTKMSDNN

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSHRGMCKVDLYSPTGQQDQDQKVIY-
FVDVST--LNMEDKDFKDA-------AGSNSEGDLNLENLEEEEIIVIKDTEKQDSSKME
RSVCLFKQAPSNPISVLYCLLSDLQKYALCFQQALSPSS-SSC------RRQVGDTEGKY
HKLP-TGNCYRGYANQLKMDYVAK-------GPQGQHLEMTAAKNTNNNQSPFTPPAKSP
SNQRTVISPDGECSTDDPSFYVSRLSPLVIQMARKKIKEKLEGGSK-CLHHSIYPPSGD-
-KGKNSPRSAVSKITSEMAHDAVEVTSAERQ-----GTG-EECR----------------
------E-------GGRKTFLY-SELSNK-S-----KGG--DK----YMCQRDNKEF---
-ADSISKMFMVYANQVASDTMFSVMQNLKVHSSGK-PIPACVVVRRVLLKHTKEIVSDLI
DSCVKNLRNITGVLMANSDF---------FSTVRRNLFNHGKQNTADIMEAMLKRLVCAL
LGEKKE-------TKSQSLSYA----------SLKAGCHDPKCK----NQSLEFSAMKAE
MK---GKGKGKMKP---EK-CKSLTSAEKGSEHTLKESLTMWN-QNQGSQGK-MA-----
------------------------G-K----------------------AW------TN-
KEEKREKISLSMDSLAKDLIVSALRLIQYYLTQQAKGKDA-FK--DCPCSTT----SYMT
Q-SAQYKKCRRSQSVKALSMKHLESRGAP---GSSTSQ--KENEHLDSQRLDMSNIVLSL
IQKLLSESS-FNCGDLCE-G-EN--KRS-------EPRTDKGASMSKRPD-KGE------
--------------------------EKCQD---------NQELDFISGMKQVSRQFIDQ
LVESVMKLCLIMAKYSNNGAALVELEEA--------------------------------
----------------------------------------------ALANNPN-YQAGGP
RC-----S------------------HDAAMSQNYQDSPGTEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNIPMLYFMGD-DAGQLKKLPEVSAKAA---EKGYRVGDLLQEVMKFTKE
QPLDEAVGNMARKQLLDWLLTNL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNN----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------HRNVNFH-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVPDASCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CERPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMANL--------------

---------------ATTYCNTTKMS--DIDWLHSCRGVCKVDLYSPVRQQEQERKVIC-
FVDVST--LNVEDNDCECG-------AGSSSDFSFNLQKLEDKEIIVIKDTEKKDQSKME
GSVCLFKQAPSDPLIVLNWLLNDLQKYALGFQHALSPST-SSC------KHKVGDTDNNC
QK---AGNCYSVYADKLSIDRMAK-------GPQRLHIELTAAKNTNNNQSSSSPIAKSS
HTQREVNSLDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSYYVNRLSSLVIQMARKEIKEKLENGNK-CPHHSPYLPVGD-
-KGKSSPRSPLSKIASEMAHEAVELTSSEMR-----GTV-EENK----------------
------E-------GGQKTFMY-GELSNK

PF05716 // ENSGT00420000029845_Domain_2 (390, 687)

-S-----KCG--EK----QLFQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSTGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VCAVKRNLFNHGKQNAADIMEAMLKRLVNAL
LGEKKE-------TKSQSLSYA----------TLKTGSQDAKCK----NQSLEFSAMKAE
MK---GKDKDKMKS---DP-CKSLTSAEKVSEHILKESLTMWN-QKQGNPCQMST-----
--------------------------K----------------------LC------A-S
KDEKKENLSPSTDSLAKDLIVSALRLIQYHLTQQAKGKDT-LEE-DCPGSSL----GYVA
Q-STQYEKCGGGQNARTISMKHLESRGAP---GPSTCP--KETQ----QKLDMSSIVLSL
IQKLLGEGPSLTCDELCE-G-EN--RCA-------ESRANKVSSMARRSD-KCE------
--------------------------VQCQD---------NAELDFISGMKQMNRQFIDQ
LVESVMKLCMIMANYS-NKESFAELEEQ--------------------------------
---------------------------------------------EAGLTSN--LNIGSS
RC------------------------QEATMSRN-RDCSGPEIIVNNQCS-TSNLQKQLQ
AVLQWIAASEFNVPMLYFVGD-DEGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMAKKQLLDWLLSHL--------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDLDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGKLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQMAHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISSRTAVSKIASEMAHEAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTNGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRASKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSGAMPQNY

PF05716 // ENSGT00420000029845_Domain_5 (1116, 1223)

QDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGNVARKQLLDWLLANL--------------

------------------------MSD-R

PF05716 // ENSGT00420000029845_Domain_2 (30, 1169)

VDWLQSQTGVCKVDVYSPGDDLPQDWKMXX-
------------------------------------------------------------
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XX-----X---XX---X
X-------------XXXXXXXXXXX-------XXXXXXXXXXXXXXX--XX---------
--XXXXXXXXXXXXXXXXXXXXXXXTNLVIAMAKE--IERIDGSESKCIHQSVYVG--D-
-AAP----KKSSKVASELVNETVSACSRNSTSDKAPGSYDRASGTSQSPVNVKYKSALKI
KDSTKESRGPDDKPSSKKSFFY-KEVFESCNASDATEGRR-SLPAEGEMLRE--QEKPND
FTASVSQGIITYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLIKHAEEVVSDLI
DSFMKNLHDVTGALMTDTDF---------VSAVKRSLFVHGSQKATDIMDAMLSKLYSVI
FAKKPPETVRETKDKSESYSLM----------SVKGT-SDPK------NRNVSFASMKSE
GKLR---EK--IGSPA-PKPEKEKTCVETLGEHIIQEGLSLWHKNQQK-EGKS-------
--------------PDLQCAPLAASNKQHK-------PAPDSPSGVPLDPSNLSPS--TH
HPEKLENFMHDSESWARXXXXXXXXXXXXXLAQGGSMDAQSLVK--AAGGT-----NLQA
SK--------------SPAISDESGIRSP---------HM-GVDQEAAEKKDLMSVFFNF
IRNLLGETI-FKSDRSSEPKPTKE------RQ-------SCERPVSPSPIKLNEGD----
---------------------------EAGGTFAGLTKKVANQLD-----DHMNKQMVEH
LMDSVMKLCLIIAKSCDS--PLAEV-----------------------------------
----------------------------------------ESNKSGDTNRPTSSSPDSLH
EC-LSTKGTGAAEILLKNAYETIYNELRGISAPLPEGSAAPKVIVSSHNLADTVQNKQLQ
AVLQWVAASELNVPVLYFAGY-DEGIQEK-------------------------------
-------------------------------------

---------------MMACFDTTMMSD-DIDWLRSSRSVCKVDLYKPAGQQDQDRKVVC-
FVDVST--LNVEDKDCKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQASSDPISVLNWLLSDLQKYALGFQHALSPST-SSC------KHKVGDTEDGC
NRSS-SGNCYSVYADQLNTDWL-N-------RHHNLQLEMAAAKNTNNNQSPSATSAKSL
STQRAVISPDGECSL

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYANRLSSMVVQMA

ENSGT00420000029845_Linker_0_2 (274, 337)

RKEIRDKLEGRSK-CLHHSIVPSP---
---------TVSKIASEMAHEAMELTAAEMC-----

PF05716 // ENSGT00420000029845_Domain_2 (337, 685)

GTG-EECK----------------
------E-------GGQKSFLY-SELCNK-N-----KSG--DK----QICQRDSKEF---
-ADSISKGLMVYANQVASDMMFSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLRRLVSAL
IGEKKE-------TKSQSLSYA----------TLKAGSHDPKCN----NQSLELSAMKAE
MK---GKDKCKMKS---DP-CKSLTSAEKVGEHILKEGLTMWN-QKQGNPCKIA------
------------------------T-K----------------------VC------CN-
RDEKREMISASTDSLAKDLIVSALKLIQYHLTQQARGKDA-CEE-DCPDSTT----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHGAP---GPSTCL--KENQRIDCQKMDMSNIVLML
IQKLLNES--SNCEDPCE-G-EN--KRS-------EPKVNKATSMSRRPD-KGE------
--------------------------EQCQN---------HQEFDFISGMKQVNRHFIDQ
LVESVMKLCLIMAKYSKNGAALAELEEQ--------------------------------
---------------------------------------------AASTSKPTF---RGT
RC-----T------------------HNDAMPQNYQDSPGHEVIVNNQCS-TNNLQKQLR
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPQVSAKAA---EKGHSVGSLLQEVMKFAKE
WQLDEAVGNVARKQLLDWLLTNL--------------

---------------MIAYCGTTTMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNMEDKDSKGA-------AGSRSEGELNLETLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGDY
SKIP-SENCYSVYADQVNLDYLNK-------GPQNLRLEMAASKNTNNNQSPSNPATKSP
SNQRSVATPEGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 338)

RKEIKDKLEGGSK-CLHHSMYTS-GD-
-KGKTSPRSAVSKIASEMAHEAVELTSSEMR-----G

PF05716 // ENSGT00420000029845_Domain_2 (338, 719)

NG-EDCR----------------
------D-------G-RKTFLY-SELCNK-N-----KCGE-KQ----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTNDPKCK----NQSLEFSAMKAE
MK---GKDKCKSKA---DPCCKSLTSAERVSEHILKESLTMWNNQKQGNQGKVTN-----
--------------------------K----------------------VC------CTS
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDP-CEE-E-PGSSM----GYMS
Q-SAQYEKCGGGQSSKSLSMKHFETRGAP---GPSTCM--KEN-QLESQKMDMSNMVLSL
IQKLLSESP-FSCDELTE-S-DNK-RCC-------DPRSSKAAPMAKRP----E------
--------------------------EQCQD---------NAELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALVG-------SGS
RC-----G------------------RDAMMSQNYPETPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MAD-RVDWLQSQNGVCKVDVYSPGVNQHQDWKM---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEKSTAGFQDSRFKPG-ESSFG-----EDGAIP-GDQ
R-------------KGLCVDYYNTT---NKGSPGRLHFEMTHKENPS--PG---------
--PIAQP--GNASSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIHGSENKCIHQSFYMG--D-
-EPV--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALGSAQSP-RLRYKSTLKI
KESTKDGKCPDDKPTSKKSFFY-KEVFESRNAGDAKDGGR-PLPGDRKLFKG--QDRTDD
FTSSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRKARDKSESYSLI----------SMKSRPGDPR------QPNMNFS-MKSE
SKMR---ES--LFSA--CKPEKEKTCAETLGEHIIKEGLTMWHKTHQK-DCKT-------
--------------PGLDHAAKQD----SA--------QPEVPFESP-DPCDLSPT--PQ
QPEAFENFMCESDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAAST-----NFPA
TK--------------TPVVHDESKLKS----------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSKRNCESKG--QNVREEEINQ-------CEKPMTPPE-----EEE---
--------------------------EETGGALSGLTKMVANQLD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

---------------VTTYSDTMMMSD-DIDWLHSRRGVCKVDLYSPTGWQDQDRKVIC-
FVDVST--LNVEDKDSKNA-------AD-CSEGELSLENLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVRDTESEY
HKVP-SGNCYSVYADQLNMDCFSN-------GSHNLRLEMTAAKNTNNNQSPSTPPAKSP
SSQRAVISSDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKEKLEGGSR-CLHHAIYPSPGD-
-KGKNSPRSAVSKIASEMANEAVEVTSAEMH-----GSG-EECK----------------
------E-------GGQKTFLY-SELSSK-N-----KSG--

PF05716 // ENSGT00420000029845_Domain_2 (402, 728)

DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------SKSHSLSYA----------SLKAGSHDPKCK----NQNLEFSAMKAE
MK---GKDKGKIKS---DQ-CMSLTSAERVSEHILKESLTMWN-QKQGNQCK-MP-----
------------------------T-K----------------------VC------AN-
RDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-FEE-ECPGSTM----GYMA
Q-SAQYDKCGSGHSAKALSMKHLESRGAP---GPSTSL--KEHQQLDSQKLDMSNIVLTL
IQKLLNEST-FNCDDLSE-G-EN--KRS-------EPRASKATSISKRSD-RGE------
--------------------------EQCQD---------NQDHDFISGMKQVNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALANNAN-FR--GP
RC-----N------------------QDAAMPRNYHDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMRFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MAD-KVNWLQSQNGVCKVDAYSPGEGQPQDWKT---
------------------------------------------------------------
-------EMSTDPVRVLSWLRRDLEKSTAEFQDTRFKPG-ESSVG-----AEVANP-GDP
R-------------KGFSVDYYNTT---SKGSPGRLHFEITHKETPS--Q----------
------S--GNRSSVDELSLFANHLTNLVIAMARKEIDEKIDGSVKKCIHQSVYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-SQRSLSTVASELVNATVSECVKNANADKAPGSGDRASG-SQSPPNMKYKSTLKI
KESTKEGKCPGDKPASKKCFFY-KEVFESRNAGDAKEGGR-SLPAEKKMFKG--KERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--STIATILLKRVLIKHAKEVVSDLI
DSFMTNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLGKLYNVV
FAKKIPDTIRRAKDKSESYSLI----------SMKGM-GDPK------YRNMNFS-MKSE
AKLR---EK--MYSE--CKPQKEKTCVETVGEHIIKEGLTMWHKSQHR-DCKS-------
--------------PCSERAASAAPNEQDN-----------TPFED-HDTCNFSPP--VH
HREDLENSIWESESWAKDLIVSALLLIQYHLAQGGRMDPQSFLE--AANTT-----NFPH
NK--------------CSASPNEPNLKCP---------RK-VCDQEQTGKKDLMSVFFNF
IRNLLSETI-FKSDRCSEHKV---QIKE--DSQ-------CERPVSPCSTKPCEDY----
---------------------------ESGGPFSELTKMVASQVD-----GHMSGQMVEQ
LIDSVMKLCVIIAKSCDS--SLVEL-----------------------------------
----------------------------------------GDDKCGDASRPSSALPDSLY
EC-LPVKGTGTAEALLQNAYQNIHNELRCLSGQMPEGCASPKVIVSNHNLTDTVPNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSD-DIDWLRSRRGVCKVDLYNPAGQQDQDRKV---
-----------------DA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQ--SK
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-SIC------KHKVEDTEGEY
HTES-SENCYSVSADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNESPSATPAKPP
STQRAVISPDGECSIDDLSFYVNRLSSLAIQMAHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISPQTAVSRIASEMAHEAVELTAAEMH-----G

PF05716 // ENSGT00420000029845_Domain_3 (338, 453)

TE-EESR----------------
------E-------GGQKSFLY-SEFSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHS

ENSGT00420000029845_Linker_3_2 (453, 471)

SGK-PVPACVLTLALFSP

PF05716 // ENSGT00420000029845_Domain_2 (471, 526)

QLPQVSAKAA
E----KGYSVGGLLQEVMKFAKERQLDEAVGKVARKQLLDWLLDNL--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

----------------------------------------------MKPYLFLSLFQ---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEQSTARFRDSRFKPG-ETSFG-----EEVAVP-GDQ
C-------------KGFGVEYYTTT---NKGSPGRLHFEVTHEENPS--QG---------
--PGTQV--CNGNSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGLENKCVHQSFYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1170)

-PHKSLSTVASELVDETVSACSNNMASDKAPGSGDRDLGSTQSP-SLRYKSTLKI
KESTKDGKCPDDKPGSKKSFFY-KEVFESRNTGDAREGGR-PLAGDRKLFRC--QDRTDD
FTNSVSQGIMTYANSVVSDMMVSIMKTLRIQLKD--TTIITMLLKKVLIKHAKEIVSDLI
DSVMKNLHNVTGSLMTDSNF---------VSAVKRSLFSHGSQNATDIMDAMLGKLYNVM
IAKKFPDTLTKARDKSESYSLI----------SMKTR-GDSK------YPNGKFA-MKSE
EKLR---EN--LFSA--CKPEKEKTCAETLGEHIIKEGLTMWHKTQK--DCKS-------
--------------PGFEHASFGASNKQCN-------PPPDVSSKCP-DPCDFTPL--PQ
QPENFENFMCDSDSWAKDLIVSALLLIQYHLAQGSRMDAQSFLE--AAAST-----SFPT
TK--------------PPVVHDESRLKS----------PHKICNQEQSEKKDLISVIFNF
IRNLLSETI-FKSSPNLEPKAPEQQVKEEDINRYERPMT--------PSPKFCDKE----
---------------------------EAGGTLSGLTKIVANQLD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDT--PLAEL-----------------------------------
----------------------------------------GNKKCGDANRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGQLPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKVRKTRKLSE---G------------------
-------------------------------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNN----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------HRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CDRPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------MSD-KVDWLQSQNGVCKVDVYSPGDSQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-ESSFG-----GEMSNS-GDP
H-------------RGFSVDYYNTT---AKGTPGRLHLEITHKENPF--QG---------
--PRAQL--GNESSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINETIDGSENKCVHQSLYIG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1169)

-PTKSLSKVASDLVNETVSACSRNAAPDKAPSSGDRASESSQKPPNLKYKSVLKK
KESTKERQGPEDKPDSKKSFFY-KEVFESRNADYAREGGR-FLPWERKMFRG--QERADD
FATSVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATVLLKKVLLKHAKEVVSDLI
DSFMRNLHNVTGTLMTNTDF---------VSAVKRTVFSHGSQKATDIMDAMLGKLYNVM
FAEKVSEHIRKAKDKAESYSLL----------SMKGM-GDPR------KRNVNFA-MRSE
AKFR---EK--MYSE--AKSEKEKTCAETLGEHIIKEGLTLWHKN-QK-ECKS-------
--------------PGFQHAAFEAPDAQCK-------PAPDISFDFPEDICSLSPP--QY
PPEKPENFMFNSDSWAKDLIISALLLIQYHLAQGGRRDAQSFLE--AAGTP-----NFPA
NK--------------SPVVPDESCLKTA---------HN-VDDQEQAEKKDLMSVFFNF
IRNLLSETI-FKRGHCSEPKVPEQLVTED-INL-------CERPLTSSPPKPCEHD----
---------------------------ETPGAVSGLTKMVISQLD-----GNVNGQMVEH
LMDSVMKLCLIIAKSCDT--SLTEL-----------------------------------
----------------------------------------EDDKSGDASRLTSAFPDSLY
EC-LPVKGTGTAETLLQNAYQAIHNELRGISGQSPEGCAAPKVIVSNHNLIDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEK-------------------------------
-------------------------------------

------------------------MAD-RVDWLQSQSGVCKVGLYSPGDNQHQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFG-----EEVAYP-VDQ
R-------------KGFCVDYYNTT---NKGSPGRLHFEMSHKENPS--QG---------
--LIAHV--GNGGSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGTENKCVHQSLYMG--D-
-EAT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVTACSKNIAGDKAPGSGDRASGSSQAS-GLRYTSTLKI
KESTKEGKCPDDKPGTKKSFFY-KEVFESRNAGDAKEGGR-SLPGDGKLFRSGTDNRPDD
FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMKHAKEVVSDLI
DSFMKNLHGVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
CAKKFPDNTRRARDKSESYSLI----------SMKSRAGDPK------LSNLNFA-MKSE
SKLK---EN--LFST--CKLEKEKTCAETLGEHIIKEGLHMWHKSQQ----KS-------
--------------PGLERAAKQA----NA--------SQEVSFECP-DPSEANSPHQPQ
PPENFANFMCDSESWAKDLIVSALLLIQYHLAQGGKMDAQSFLE--AAAST-----NFPT
NKP----------APPPPVVHDECKLKSP---------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKGSRNCESNVHEQNIQEEEVNRCERPKTPCERPITPPAPKFCEDEE---
---------------------------ATGGALSGLTKMVANQLD-----GCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GEEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KAFSVDYYNN----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVHQSLYIG--N-
-EPP-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPEKSPGSGDRASGSSQSPPNLKYKSTLKI
EERTKERQGPEDKPASKKSFFY-KEVFESRNGDYAKESGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDTCNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----KFPA
NE--------------PPVVPDESCLKSA---------PT-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CERPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEAVLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------KIAYSDITKMSD-N

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPKGQREQDRKLIC-
FVDVST--LNVEDKDSKDA-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALSVQHALSPSA-SSC------XXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXX--XXXXXXX-XXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXX-XXXX----------------
------X-----XXXXXXXXXX-XXXXXX-X-----XXX--XX----XXXXXXXXXX---
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
SSCM-NLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------IKSQSLSYA----------SLKAGSHDSKCK----NQSLEFSTMKAE
MK---GKDQGKTKP---DP-CKSLTSAEKVGEHILKESLTMWN-QKQGNQGKMAS-----
--------------------------K----------------------AC-------TN
KEEKRENISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDT-FEE-DCPGSTM----SYMT
Q-SAQYEKSGCGQSAKALSMKHLESRGAP---GPSTSL--KETQQVDSQKLDMSNIVLSL
IQKLLSESP-FNCDELSE-S-EN--KHS-------EPKSNKATSMTKRG-----------
-------------------------EEQSHD---------SQELDILSGIKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGEALAELEEQ--------------------------------
---------------------------------------------AALANNLS-YQAGGP
RC-----G------------------HEGAMSRNYQDSPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---DKGYSVGDLLQEVMKFAKE
RQLDEAVGNIARKQLLDWLLTNL--------------

------------------------MSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LIVYDKDNKAR-------GGPSSEGELDLESLEEKEIIVIKDTEKLDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSS-SSC------KHKVGDLEGGY
RSHPNKDNCYSVYADELSMDYMAN-------NPHNLRLEMAAAKNTNNNQSPSSPPAKSP
STQRAVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 324)

RKEIKEKLEGGSK-CLHHSIYASTGD-
-KGKNSPRSAVSKIASEMAHDAV

PF05716 // ENSGT00420000029845_Domain_2 (324, 1223)

EVTSAEMR-----SPGDLD------------------
------H-------KDRKTFLY-SELSNK-S-----KGGS-DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA----------SLKAGTHDCKNKN---QTGLEFSAMKAE
MMKGGGKDKGKMKP---DQ-CKSLTSAEKVSEHILKESLTMWN-QKQTGGQTKCH-----
------------------------AST----------------------KV------GPC
REEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDG-LEE-PVIEQPASTMAYSMT
Q-GGHYEKCGSGQSAKALSMKHLESRSTAQCAGPST-----SPKELDTQKLDMSNIVLML
IQKLLSESP-FSLEEQCE-G-ES--KRA-------ESKSKVSSCTSKRSD-RGE------
--------------------------EHFQD---------HQEFDFISGMKQVNRQFVDQ
LVESVMKLCLIMAKYSNNGAGLAELEEQ--------------------------------
---------------------------------------------AGANPANF-RASSNS
RC-----A------------------QDAMMSHSYHESPGPEVIVNNQSS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-EDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSE-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNTT---TKGTPERLHFEMTHKEIPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVYQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKI
KESTKERQGPDDKPPSKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFLRNLHSVTGTLMTDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVRKAQDKAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EK--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKTQQK-ECKS-------
--------------LGFQHAAFEAPNTQRK-------PASDISFEYPEDIGNLSLP--PY
PPEKPENFMYDSDSWAEDLIVSALLLIQYHLAQGGRRDARSFVE--AAGTT-----NFPA
NE--------------PPVAPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSPEPKVPEQPVKED-RKL-------CERPLASSPPRLYEDD----
---------------------------ETPGALSGLTKMAVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDA--SLAEL-----------------------------------
-----------------------------------GD-----DKSGDASRLTSAFPDSLY
EC-LPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------MIAYCGAKMMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLETLEEKEIIVIKDTEKQDQTKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGEY
SKIP-SENCYSVYADQVNLDYLNK-------GPQNLRLEMAASKNTNNNQSPSNPAAKSP
SNQRSVATPEGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKDKLEGGSK-CLHHSMYTS-GD-
-KGKTSPRSAVSKIASEMAHEAVELTSSEMR-----GNG-EDCR----------------
------D-------G-RKTFLY-SELSNK-N-----KCGE-KQ----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTNDPKCK----NQSLEFSAMKAE
MK---GKDKCKSKA---DPCCKSLTSAERVSEHILKESLTMWNNQKQGNQGKVTN-----
--------------------------K----------------------VC------CTN
KDEKRERISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDP-CEE-ECPGSSM----GYMS
Q-SAQYEKCGGGQSSKSLSMKHFETHGGP---GPSTCM--KEN-QLESQKMDMSNMVLSL
IQKLLSESP-FSCDELTE-S-DNK-RCC-------DPRSSKAAPVAKRP----E------
--------------------------EQCQD---------NAELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALVG-------SGS
RC-----G------------------REAA

PF05716 // ENSGT00420000029845_Domain_5 (1111, 1223)

MSQNYPESPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-EDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLTNL--------------

------------------------MSN-KVNWLQSQNGVCKVDVYSPGEGQAQDWKT---
------------------------------------------------------------
-------EAPTDPVRVLSWLRRDLEKSTAEFQDAKFKPG-ESSFG-----EELANP-GDP
R-------------KGFSVDYYNNT---TKGSPGRLHFEITHKESPS--Q----------
------A--GNKSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANCITNLVIAMA

ENSGT00420000029845_Linker_0_1 (274, 306)

RKEIEK-NDDTVKKSVQQSLYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_1 (306, 370)

-SQKSLSTVASELVNATVSACVKNTETDKAS----------GSGDKNA-------
DT----DKAPGS---------------GDKSPRGAKEGGR-SLPAEKKTSKG--KERADD
FTGSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--STIASILLKRVLIKHAKEVVSDLI
DSFMTNLHNVTGTLMTDSDF---------LCAVKRSLFSQGSQKATDIMDAMLGKLYNMM
FANKYPETIRRAKDKSESYSLI----------SMKGM-GDPK------YRNMNFL-MKSE
AKLK---EK--MYST--CKPQKEKTCIETVGEHIIKEGLNMC------------------
------------------------------------------------------------
---------------------------------------------------------

PF05716 // ENSGT00420000029845_Domain_2 (778, 1223)

HPA
NK--------------LSAAPNES--KYP---------HK-VCDQEQTGKKDLMSVFFNF
IRNLLSETI-FKSDNCPESKV---LIKEESVNL-------CERPVTPCXXXXXXXX----
---------------------------XXXXXXXXXXKMVASQVD-----GNMSRQMVEQ
LMDSVMKLCVIIAKSCDP--SLTEL-----------------------------------
----------------------------------------GDDKCGDASRPNSALPDSLF
EC-LPVKGTGTAEALLQNAYQNIHNELRCLSGQLLEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPVLYFAGD-DEEIQKKLLQLSAAAV---EKGRSVGEVLQLVLRYEKE
RQLDEAVGNVTRLQLLDWLMLNL--------------

---------------AIAYSHTTKMSD-DIDWLHSRRGVCKVDLYSPTGRKDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGCSSEGDLNLESLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDIDGEY
HKIP-SENCYSVYADHVNMDYMAN-------RPQSLCLEMAAAKNTNNNQSPSTPPGKSP
STQRAVISPDGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMARKEIKEKLEGGSK-CLHHLMYPPSGD-
-KGKNSPRSAVSKIASEMAHEAVELTSAEMR-----GPG-EEGK----------------
------D--------GRKTFLY-SELCNK-N-----KSG--EK----QMCPRDSKEF---
-AESISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTREIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGERRE-------TKSQSLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKGKIKT---DP-CKPLTSAEKVSEHILKESLTMWN-QKQGNQGK-MT-----
------------------------T-K----------------------LC------PA-
KDEKRERISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDT-LEE-ECPGSSL----NYMA
Q-SAQYEKSGGSQSAKTLSMKHLESRGAP---GPSC-V--KENQQLDSQKLDMSNIVLSL
IQKLLNEGS-FSCDDLCD-G-EN--KRS-------EPRSKTP-SMSK-KG-ERE------
--------------------------DPCQD---------NPELDFMCGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALASNPNF----GS
RC-----G------------------YEAAM

PF05716 // ENSGT00420000029845_Domain_5 (1112, 1223)

SQTCQDSPGPEVIVNNQCS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------ASSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HRAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEMTAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 296)

AHKEIKEKLEGKSK-CLHHSICP

PF05716 // ENSGT00420000029845_Domain_2 (296, 718)

SPGN-
-KERISPRTPASKIASEMAYEAVELTAAEMR-----GTG-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSLMKTLKVHSSGK-PIPASVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNATDITEAMLKRLVSAL
IGEEKE-------TKSQSPSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---ERDKGKMK----LDPCKSLTSAEKVGEHILKEGLTIWN-QKQGNSCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKQLESHRAP---GPSTCQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KCS-------EPRASKAASMSNRSD-KGE------
--------------------------EQCQE---------HQELDCTSGMKQVNGQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------SASANKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQPDEAVGKVARKQLLDWLLANL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNT----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EERAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPRERRRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------HRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CDRPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

------------------------------------------------------------
---------------------------------------------------MDITGCYME
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVEDTEGEY
HTES-SKNCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSATPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 297)

AHKEIKEKLEGRSK-CLHHSIYPS

PF05716 // ENSGT00420000029845_Domain_2 (297, 613)

PGN-
-KERISPQTAVSKIASEMAHEAVELTAAEMR-----GTE-EKSR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PVPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKVLNMK---SGEVA------KVPKHFQ-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQM

ENSGT00420000029845_Linker_0_2 (273, 338)

AHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISPRTAVSKIASEMAHEAVELTAAEMR-----G

PF05716 // ENSGT00420000029845_Domain_2 (338, 718)

TE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRASKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSSAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

------------------------MSE-KVDWLQSQNGVCKVDVYSPGDNQAQDWKT---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNTT---TKGTPERLHFEMTHKEIPC--QG---------
--PRAQL--GNRSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVSQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSALKI
KESTKERQGPDDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPRERKRFRG--QERPDD
FTASVSEGIMSYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFLRNLHSVTGTLMTDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVRKAQDKAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EK--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAAFEAPNTQCK-------PASDISFEYPEDIGNLSPP--PY
PPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFVE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSPEPKVPEQPVKED-RKL-------CERPLASSSPRLYEDD----
---------------------------ETPGALSGLTKMVVNQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDA--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTLAFPDSLY
EC-LPVKGTGSAEAVLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

-------------------------MS-E

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

VDWLQSQNGVCKVDVYTPYDSQPQDWKI---
------------------------------------------------------------
-------EASTDPIRVLSWLRRDLEKSTAEFQDVRFKPG-ESPLS-----GESPSL-VDP
R-------------MGFSVDYYNNT---NRGTPGRLHFEVSHKEKPA--QG---------
--LSTQI--GNGSSMDEVSFYANRLTNLVIAMARKEINEKIDGSENKCIHQSVYVG--D-
-EPP--LNKSLSNVASELVNKTVTECSKSAASDKAPGSGDKASASPQSPPNLKYKSTLKI
KESTKPNKCPDDRPSSKKSDFY-KEEFESRNSGDAREGGKSFLPGERKLFRG--QERPDD
FTTSVSQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLIKHAKDVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMMGKLYTVI
FSKKSPGAIRRTQGMSECYSLI----------S-KGM-GGPK------SRNVNFASMKSE
GRMR---EN--TYTAT-CKPEKEKSCVETLGEHFIKEGLSLWHKNQNK-DVKS-------
--------------PGFQRASFDTPNKQFR-------PTPDIPLDFPLDTCGFSPP--MC
PQEKPENFMCESDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLE--AAGNT-----SLPK
-K--------------SPTVCEDPSLKSP---------LL--GGQEESGKKDLMSVFFNF
IRNLLSETI-FKNDRCS--AKPEQPMKEE-NCQ-------CERPVTPCPIKTCEGE----
---------------------------EVSEPFAGLTKMVANQFD-----GQMNGQVVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDEKCGDASRPTSAFPDSLY
EC-LPVKGTGTAEALLQNAYQAIHNELRCSSGQPPEGCMAPKVIVSNQNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVDL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGENQPQDWKT---
------------------------------------------------------------
-------EAPVDPVRVLSWLRRDLEKSTAGFQDVRFKPG-ESSLG-----GETTNL-GDS
H-------------KGFSVDYYNTT---NKGSPGRLHFEMTHRESPP--QG---------
--PRVQI--GAGSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVHQSLYMG--D-
-DPPP

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

PPNKSLSKVASELVNETVTACSQNAAPDKVPGSGDRASGS-----NLKYKSTLKM
KA----SKSPDDKPGSKKSFFF-KEEFESRNAGDAREGKK-FLPGERKMFQG--QERTDD
FTTSVSEGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSVFSHGSQKATDIMDAMLGKLYNVI
FAKKIPETIRKSKDKCESYSLV----------SMKGL-GDPK------NRNVNFT-MKSE
AKMR---EK--MYSPM-PKPEK-KTCVETLGEHIIKEGLIMWHKNQQK-ECKS-------
--------------PGFQHPAGESPNKPCK-------PAPDFPFEYPQDPSDFSPP--LC
HPERPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAATT-----NFPP
NK--------------PPVVPDESCLKSP---------QV-VGDKEQAEKKDLMSVFFNF
IRNLLGETI-FKNDRSCEAKMPEQPVKEEDISH-------CERPATPCPVKLYEGE----
---------------------------ESGGALSGLTKMVVNQLD-----GQMNGKMLDH
LMDSVMKLCLIIAKSCDT--PLAEL-----------------------------------
----------------------------------------GDDKCGDASRPSSALPDSLY
EC-LPVKGTGTAEAILQNAYQAIHNELRGISGQPLEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

---------------MIAYCGTTTMSD-DIDWLHSRRGVCKVDLYSPKGQQDQDRKVIC-
FVDVST--LNVEDKDSKGA-------AGSRSEGELNLETLEEKEIIVIKDTEKQDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDLEGDY
SKIP-SENCYSVYADQVNFDYLNK-------GPQNLRLEMAASKNTNNNQSPSNPATKSP
SNQRSVATPEGECSM

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 338)

RKEIKDKLEGGSK-CLHHSMYTS-GD-
-KGKTSPRSAVSKIASEMAHEAVELTSSEMR-----G

PF05716 // ENSGT00420000029845_Domain_2 (338, 654)

NG-EDCR----------------
------D-------G-RKTFLY-SEMCNK-N-----KCGE-KQ----QMCPKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSL-------AYATL---KAGTNDPKCK----NQSLEFSAMKAE
MK---GKDKCKSKA---DPCCKSLTSAERVSEHILKESLTMWNNQKQGNQGKVTN-----
--------------------------K----------------------VC------CTS
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDP-CEE-ECPGSSM----GYMS
Q-SAQYEKCGGGQSSKSLSMKHFETRGAP---GPSTCM--KEN-QLESQKMDMSNMVLSL
IQKLLSESP-FSCDELTE-S-DNK-RCC-------DPRSSKAAPMAKRP----E------
--------------------------EQCQD---------NAELDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALVG-------SGS
RC-----G------------------RDAMMSQNYSETPGPEVIVNNQCS-TTNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQPQDSRM---
------------------------------------------------------------
-------ETPMDPVRVLSWLRRDLEKSTAGFQDLRFKPG-ESSLG-----GEMINS-GDP
R-------------KGFSVDYYNTT---NKGSPGRLHFEITHREKPS--HG---------
--STVPT--GSGSSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCIHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PSKSLNKVASELVNETVSACSKSAASDKVPGSGDRASGS-----NVKYKTTLKM
KESTEESKSPNDKPASRKSFFY-KEVFESCNAGDAREGRK-FLPGERKMFQG--QERPDD
FTASISEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMLSKLYNVM
FAKKVPEIVRKSKDKSESYSLV----------SMKGM-GDPK------HRNMNFA-MKSE
AKLR---EK--MYSPV-PKPEKPKTCAETLGEHIIKEGLSLWHKNQQK-ECKS-------
--------------PGFQRATFEAPHKPCK-------PVPDFPFEYLQDPCNFSPP--VC
YPETPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAATT-----NFPA
KK--------------SPVVPDESCLRSP---------HV-VGDKEQSEKKDLMSVFFNF
IRNLLGETI-FKNDHSCQP----NPVKEEDSNP-------CERPATPPPVKLCEGD----
---------------------------EAGGTFSGLTKMVVTQLD-----GQMGGKMVDH
LVDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKCGDANMPTSAFADNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGISGQPPEGCAAPKVIVRNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

------------------------MAD-RVDWLQSQSGVCKVGVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPG-ESSFV-----EEVAYP-VDQ
R-------------KGFCVDYYNTT---NKGSPGRLHFEMSHKENPS--QG---------
--LIAHV--GNGGSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGAENKCVHQSLYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVTACSKNISGDKAPGSGDRASGSSQAP-GLRYTSTLKI
KESTKEGKCPDDKPGTKKSFFY-KEVFESRNAGDAKEGGR-SLPGDRKLFRTSPDNRPDD
FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLMKHAKEVVSDLI
DSFMKNLHGVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRRARDKSESYSLI----------STKSRAGDPK------LSNLNFA-MKSE
SKLK---EN--LFST--CKPEKEKTCAETLGEHIIKEGLHMWHKSQQ----KS-------
--------------PGLEHAAKLG----NA--------PQEVSFECP-DPCEANPPHQPQ
PPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLE--AAAST-----NFPT
NKP----------PPPPPVVQDECKLKSP---------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEE---
---------------------------ATGGALSGLTKMVANQLD-----NCMNGQMMEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GEEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSATAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDNQAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFG-----GETSNS-GDP
H-------------KGFSVDYYNN----TKGTPERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYMG--N-
-EPP--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRASGSSQSPPNLKYKSTLKI
EEHAKERQGPEDKPASKKSFFY-KEVFESRNGDYARESGR-FFPRERKRFRG--QERPDD
FTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTLATILLKKVLLKHAKDVVSDLI
DSFMRNLHSITGTLMTDTQF---------VSAVKRTVFTHGSQKAADIMDAMLRKLYNVM
FVKKVPEHVRKAQDTAESYSLI----------SMKGM-GDPK------NRNVNFA-MKSE
TKLR---EQ--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHAACEAPNTQCK-------PSPDISFEYPEDICNLSPP--PY
PPEKPENFICDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFLE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKRDQSSEPKVPEQPVKED-RKL-------CERPLAPSPPKLCEDD----
---------------------------ETPGALSGLTKMVVSQID-----GHMSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTSAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------MMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGNLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQMAHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISPRTAVSKIASEMAHEAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPCKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN

PF05716 // ENSGT00420000029845_Domain_2 (720, 1071)

-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KENQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRASKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSSAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

---------------MMAYSDTTMMSD-DIDWLRSHRGVCKVDLYNPEGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------ASSSSEGNLNLGSLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPST-STC------KHKVGDTEGEY
HRAS-SENCYSIYADQVNIDYLMN-------RPQNLHLEMTAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQMAHKEIKKKLEGKSK-CLHHSICPSPEN-
-KERISPRTPASKIASEMAYEAVELTAAEMR-----GTG-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRESKEF---
-ADSISKGLMVYANQVASDMMVSLMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNATDITEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---ERDKGKMK----SDPCKSLTSAEKVGEHILKEGLTIWN-QKQGNSCK-VA-----
------------------------T-K----------------------AC------SN-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTKGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKQLESHRAP---GPSACQ--KENQHLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-ES--KCS-------EPRASKAASMSNRSD-KGE------
--------------------------EQCQE---------HQELDCTSGMKQVNGQFIDK
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AASANKPNF---RGT
RC-----I------------------HTGAMPQNYQ

PF05716 // ENSGT00420000029845_Domain_5 (1117, 1223)

DSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASHFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
WQLDEAVGKVARKQLLDWLLANL--------------

---------------LMAYSDTTTMSD-DIDWLRSHRGVCKVDLYNPAGQQDQDRKVIC-
FVDVST--LNVEDKDYKDA-------AGSSSEGKLNLGNLEEKEIIVIKDTEKKDQSKTE
GSVCLFKQAPSDPVSVLNWLLSDLQKYALGFQHALSPSA-STC------KHKVGDTEGEY
HTAS-SENCYSVYADQVNIDYLMN-------RPQNLRLEIAAAKNTNNNQSPSAPPAKPP
STQRAVISPDGECSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 273)

DDLSFYVNRLSSLVIQMAHKEIKEKLEGRSK-CLHHSIYPSPGN-
-KERISSRTAVSKIASEMAHEAVELTAAEMR-----GTE-EESR----------------
------E-------GGQKSFLY-SELSNK-S-----KSG--DK----QMSQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLRHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNQWKQNAADIMEAMLKRLVSAL
IGEEKE-------TKSQSLSYA----------SLKAGSHDPKCR----NQSLEFSTMKAE
MK---GRDKGKMK----SDPYKTLTSAEKVGEHILKEGLTIWN-QKQGNPCK-VA-----
------------------------T-K----------------------AC------SN

PF05716 // ENSGT00420000029845_Domain_2 (720, 1069)

-
KDEKGEKINASTDSLAKDLIVSALKLIQYHLTQQTNGKDT-CEE-DCPGSTM----GYMA
Q-STQYEKCGGGQSAKALSVKHLESHRAP---GPSTCQ--KEDQPLDSQKMDMSNIVLML
IQKLLNENP-FKCEDPCE-G-EN--KHS-------EPRASKATYMSKRSD-KGE------
--------------------------EQCQD---------HQELDFISGMKQVNWQFIDK
LVESVMKLCLIMAKYSNDGAALAELEEQ--------------------------------
---------------------------------------------AASADKPNF---RGT
RC-----I------------------HSGAMPQNYQDSLGHEVIVNNQCS-TNSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-KDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
RQLDEAVGKVARKQLLDWLLANL--------------

------------------------MSD-RVDWLQSQNGVCKVDVYSPGDSQPQDWRL---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLERSTAGFQDARFKAG-ESSLG-----GEMTIS-GDP
R-------------KGFFVDYYNTT---NKGSPGRLHFEMTHRDNPS--QG---------
--PSAQT--GNTSSVD

PF10522 // ENSGT00420000029845_Domain_0 (257, 274)

EVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINETIDGSENKCIHQSLYMG--D-
-DPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PNKSLSAVASELVNKTVAACSKNGTSDRVPGSGDRASGLLQSSPNLKYKTTLKI
KESSKESKGPDDKPASKKSFFY-KEVFESRNEGDTKEGGR-SLPAERKMFRG--QERPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIITILLKKVLIKHAKKVVSDLI
DSFMKNLHSVTGTLMTDSDF---------VSAVKRSLFSQGSQKATDIMDAMLGKLYTVI
FTKRPPENIRKTKDKAESFSLV----------SMKGM-GDPK------NRNVNFATMKSE
GKLR---EK--MFCHA-SKPEDEKTCAKTLGEHLIKEGLTLWHKNQQR-EGKF-------
--------------PSLQQATFAAPNEQCK-------PTPESLLGYPLDTCNFIPP--MH
DPEKLENFMCDSGSWAKDLLISALLLIQYHLAQGGSMDPQSFLE--AAGST-----NFPI
NK--------------SPEVSDEPR---I---------HL-GGDQEEAEKKDLKSVFFNF
IQNLLSETI-FKSDHSSEVKVPEQPIREGEGRQ-------CERPVTPSPIKLSEDD----
---------------------------EAGGPFAGLTKMVVNQLD-----GHMNGQMIEH
LTDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSALPDSLY
AC-LPAKGTETAEALVQNAYQAIHNELRG-SGQPPEECAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMVNL--------------

---------------MMACFDTAMMFD-DIDWLHSSRSMCKVDLYKPAEQQDQDRKVVC-
FVDVST--VNVEDKDCKDA-------SGSSSQDSLNLENMEEKEIIMIKDAEKKDQSKTE
GSVCLFKQDSSDPISVLHWLLSDLQKYALGFQHALSPST-SNC------KHKVEDTEDGY
NRPS-SGNCYSVYTDQVNIDLL-N-------RPQNLQLEMAAAKNTNNNQSPS---AKSL
STQRAVISPDGKCSLDDLSFYVDRLSFLVIQMARKEIMDKLEGRSK-CLHHSIVPSP---
---------TVSKIASEMAHEAMELTAAELC-----GTE-EECK----------------
------E-------GVQGSFLY-NELCNK-N-----KSG--DK----QI

PF05716 // ENSGT00420000029845_Domain_2 (410, 650)

CQRDSQEF---
-ADSISKGFMVYANQVATDMMFSTMKTLKVHSSGK-PIPACVILKRVLLKHTKEIVSDLI
DSCMKNLHTITGVLMTDSDF---------VSAVKRNLFNYGKQNAAAIMEAMLRRLVSAL
IGEKKE-------TKSQSLSYA----------TLKAGSYDPKYD----NQSLELSTMKAE
MK---GNDKCKMKS---DP-CKSLTSAEKVGEHILKEGLTMWN-QKQGNPWKMA------
------------------------T-K----------------------VS------CN-
KDEKREMISASTDSLAKDLIVSALKLIQYHLTQQARGKDT-CEE-EYPDSTT----SYMA
Q-STQYEKCGGAQSAKALSVKHLESHGDP---GSSTSL--KENQGIDSQKMDMSNIVLML
IQKLLNES--SNCEDPCE-G-EN--KHS-------EPKVNKATSMSQRPD-KGE------
--------------------------EQCQD---------HQEFDFTSGIKQMNQHFIDR
LVESVMKLCLIMAKYTKNGAALAELEEQ--------------------------------
---------------------------------------------AASTSKP--------
RC-----S------------------HNNAMPQNYQDSPGHEVIVNNQCS-TNSLQKQLC
AVLQWIAASQFNVPMLYFMED-DDGQLEKLPQVSAKAA---EKGYSVGGLLQEVMKFAKE
QQQDEAMGNVARKQLLDWLLTSL--------------

------------------------MSD-DIDWLHSSRSVCKVDLYSPRERQDQDRKVIC-
FVDVSS--LNVEDKDCKDA-------SGSSSEGNLNLGSLEEKEIIVIKDTEKQDQSKME
GSVCLFKQAPSDPLCVLDWLLNDLQKYALGFQHALSPSA-SSC------KHKVGDTEGAY
HKIP-SGNCYSVYADQLNMDYFTN-------GHQSLRLEMTAAKNTNNNQSPSTPLAKSP
STQRAVISPNGECSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DDLSFYVNQLSSLVIQMARKEIRGKLEGRSK-CFHHSIYPHTGD-
-KGKMSPCSAVSKIASEMAHEAVKMTSTEMR-----DTG-EDCR----------------
------E-------GGQKTFLY-SELSNK-N-----KGG--EK----QMCQRDSKKF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLNHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLSYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKVKVNP---DPCCKSLTSAEKVSEHILKESLTMWN-QKQGNQGK-MT-----
------------------------T-K----------------------IC------TN-
KDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKCKDP-TEE-DCPS-TM----NYMA
Q-STQYEKCGSNQSAKTLSMKHLESRGAP---GPSTSL--KESQHLDSQKLDMSNIVLLL
IQKLLNESP-FSCDDLCE-G-EN--KRS-------EPGTGKAACMSKRPD-RRE------
--------------------------EQCQN---------NQELDFVSRMKQVNQQFIDQ
LVESVMKLCLITAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AALASNLNF---GGR
RC-----S------------------HNGAI

PF05716 // ENSGT00420000029845_Domain_5 (1112, 1223)

SQSYQDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPLLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MAD-KVDWLQSQNGVCKVDVYSPGDSQPQEWKM---
------------------------------------------------------------
-------NESTDPVRVLSWLRRDLEKSTAGLQDLRFKPG-ESSLG-----EEPASP-ADV
R-------------KGFSIDYYSTT---AKGSPGRLHFEMTHKENP---QC---------
--PGTPL--GNSSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 307)

RKEINEKIDGSENKCVHQSLYLG--E-
-EPA--

PF05716 // ENSGT00420000029845_Domain_2 (307, 1223)

PTKSLSTIASELVDDTVFACSKTVAPDKAPGSGDRALGSSRSPPNFKYKSTLKI
KE----NKGPDDKPSSKKSFFY-KEVFESRNAGDAREGGR-ALPGDRKIFSG--RDRPDD
FTASVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKQVLIKHAKEVVSDLI
DSFMKNLHNVTGTLMTDTDF---------VSAVKRSLFSQGSQKATDIMDAMMGKLYNVI
FSKKFPEGTRKTKDKCESFSMV----------SMKGR-GDPK------GRNMNF--MKSE
AKIR---ER--MYST--CKPEKEKTCMETLGEHIIRQGLTMWHKNHQKDS-KS-------
--------------PATDPEPGL---------------AADPPSDSP-DVCDLSPP--LP
YPESMENFMCDADSWGKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAATT-----NFPN
SGS----------PE--------ESRPNP---------PPRVCDQEQAEKKDLMSVIFNF
IRNLLGETI-FKGDRGCASKVPEQPAREEC---------QCERPLTPCPTRLCDE-----
---------------------------EVDGTLSGLTKMVASQLD-----GRAPGHMLDH
LVDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDDKSGDASRPTSALPDSLY
EC-LPARGTGTAEALLQNAYQAIHNELRGAYGQLPEGCAIPRVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMLNL--------------

------------------------MAD-RVDWLQSQSGVCKVDVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEKSTAGFQDSRFKPG-ESSFG-----EEVANP-GDQ
R-------------KGFCVDYYNTT---NRNNPGRLHFEMTHKENPS--PG---------
--PITQT--GNGSSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGSDNKCIHQSFYMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVSSCSKNIAGDKAPGSGDRAAGSTQSP-SLRYKSTLKI
KESTKDGKCPDDKPGSKKSFFY-KEVFESRNAGDAKDGGR-SLPGDRKLFRS--PDRPDD
YTNTVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSFFSHGSQKATDIMDAMLGKLYNVM
FAKKFPENIRKARDKSESYSLI----------SMKSRAGDPR------QPNMNFA-MKSE
SKMR---ES--LFSA--CKSEKDKTCAETLGEHIIKEGLTMWHKTHQK-DCKS-------
--------------PSLDSAVKQG----SP--------QPEVSFESP-DSCDLTPP--PQ
QPEVIENFMCEQDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAAST-----NFPH
AK--------------APVVHDESRLKS----------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKSKRNCESKG--QNVREEEISP-------CERPITPPAPKFCEEEE---
--------------------------EEASGAFCGLSKMVANQLD-----GSMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLSEL-----------------------------------
----------------------------------------GDEKCGDASRPNSAFPDNLY
EC-LPVKGTGTAEALLQNAYQAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------

------------------------MSD-D

PF05716 // ENSGT00420000029845_Domain_2 (30, 1223)

IDWLHSRRGVCKVDLYSPTGQQDQDRKVXX-
XXXXXXXX---XXXXXXXD-------ATCSSPGDLSLGNLEEKEIIVIKDTEKQDQSKXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX------XXXXXXXXXXX
XXXX-XXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXX----------------
------X-------XXXXXXXX-XELCNK-N-----KGT--VK----QMCQKDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSCGK-PIPACVVLKRVLLKHTKDIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA----------SLKAGSHDPKCK----NQSLEFSAMKAE
MK---GKDKCKAKP---DP-CKSLTSAEKVSEHILKESLTMWN-QKQGNQGKAVG-----
--------------------------K----------------------AC------T-S
REERKEKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDT-LED-DCPGSSM----GYMS
H-STQYEKCGSGQSAKTISMKHQETHGAS---GSSTCT---KESQLDSQKLDMSNMVLSL
IQKLLSESP-FSCDDSSE-G-ES--KRS-------DGKVSRGTTMPRRPE-RIE------
--------------------------EPCPD---------SQDLDFISGMKQMNRQFIDQ
LVESVMKLCLIMAKYSNNGAALAELEEQ--------------------------------
---------------------------------------------AAMANNANYYP--GS
SR-----C------------------HGGMMSQGYQDSPGPEVIVNNQCS-TSSLQKQLQ
AVLQWIAASQFNVPMLYFMGD-DDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MSD-KVDWLQSQNGVCKVDVYS-GDNRAQDWKM---
------------------------------------------------------------
-------DTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPG-E-SFA-----GETSNS-GDP
H-------------KGFSVDYYNNT---TKGTLERLHFEMTHKENPC--QG---------
--PRAQL--GNGSSV

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYAHRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIDGSENKCVYQSLYMG--N-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQNPPNLKHKSILKI
KKSTKERQSPDDKPASKKSFFY-KEVFESRNGDYAREGGR-FFPQDRKRFQG--QERPDD
FTASISEGIMTYANSVVSDMMVSIMKTLKIQVKD--TTIATILLKKVLLKHAKEVVSDLI
DSFMRNLHSVTGTLMSDTQF---------VSAVKRTVFSHGSQKATDIMDAMLRKLYNVM
FAKKVPEHVGKAQDKAESYSLI----------SMKGM-SDPK------NRNVNFA-MKSE
TKLR---EK--MYSE--PKSE-EETCAKTLGEHIIKEGLTLWHKSQQK-ECKS-------
--------------LGFQHATFEAPNTQCK-------PASDISFEYPENIGNLGPP--PY
PPEKPENFMYDSDSWAKDLIVSALLLIQYHLAQGGRRDAQSFVE--AAGTT-----NFPA
NE--------------PPVVPDESCLKSA---------PI-VGDQEQAEKKDLRSVFFNF
IRNLLSETI-FKHDQSPEPKVPEQPVKED-RKL-------CERPLASSPPRLYEDD----
---------------------------ETPGALSGLTKMVVNQID-----GHVSGQMVEH
LMNSVMKLCVIIAKSCDS--SLAEL-----------------------------------
-----------------------------------GDDKLGDDKSGDASRLTLAFPDSLY
EC-LPVKGTGSAEALLQNAYQAIHNEMRGISGQPPEGCAAPKVIVSNHNLTDTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---DKGCSVGEVLQSVLRYEKE
RQLNEAVGNVTPLQLLDWLMVNL--------------

---------------YQASIQTIKMSD-DIDWLHSRRGVCKVDLYSPTGQQDQDRKVIC-
FVDVST--LNVEDKD--KE-------GGPSSEGELDLESLEEKEIIVIKDTEKLDQSKTE
GSVCLFKQAPSDPISVLNWLLNDLQKYALGFQHALSPSS-SSC------KHKVGDLEGGY
RSHPNKDNCYSVYADELSMDYVAN-------NPHNLRLEMAAAKNTNNNQSPSSPPAKSP
STQRAVISPDGECSMDD

PF10522 // ENSGT00420000029845_Domain_0 (258, 274)

LSFYVNRLSSLVIQMA

ENSGT00420000029845_Linker_0_2 (274, 323)

RKEIKEKLEGGSK-CLHHSIYASAGD-
-KGKNSPRSAVSKIASEMAHDA

PF05716 // ENSGT00420000029845_Domain_2 (323, 1223)

VEVTSAEMR-----GPGDLD------------------
------H-------KDRKTFLY-SELSNK-S-----KGG--DK----QMCQRDSKEF---
-ADSISKGLMVYANQVASDMMVSVMKTLKVHSSGK-PIPACVVLKRVLLKHTKEIVSDLI
DSCMKNLHNITGVLMTDSDF---------VSAVKRNLFNHGKQNAADIMEAMLKRLVSAL
LGEKKE-------TKSQSLAYA----------SLKAGTHDAKNKN---Q-SLEFSAMKAE
MMKGGGKDKGKMKP---DQ-CKSLTSAEKVSEHILKESLTMWN-QKQGGGQTKMH-----
------------------------G------------------------KV------GAC
REDKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDA-LEE-PEQP------GCYMA
Q-GTHYEKSGGGQSAKALSMKHLESRGSGQHAGPSTTS--CTPKELDTQKLDMSNIVLML
IQKLLSESP-FTLDEQCESG-ES--KRA-------ESKSKVSTSTSKRSE-RCE------
--------------------------EHFQD---------HQEFDFISGMKQVNRQFVDQ
LVESVMKLCLIMAKYSNNGAGLAELEEQ--------------------------------
---------------------------------------------QGLNHSPS-FRASNS
RC-----A------------------QDAMMSHSYHDNPGPEVIVNNQSS-TSNLQKQLQ
AVLQWIAASQFNVPMLYFMGD-EDGQLEKLPEVSAKAA---EKGYSVGDLLQEVMKFAKE
RQLDEAVGNMARKQLLDWLLANL--------------

------------------------MAD-RVDWLQSQNGVCKVDVYSPGDNQHQDWKM---
------------------------------------------------------------
-------DASTDPVRVLSWLRRDLEKSTAGFQDSRFKPG-ESSIM-----EEAPVP-GDQ
R-------------KGFCVDYYNTT---HKGSPGRLHFEMTHKEIPS--QG---------
--PCVRA--GNGNSI

PF10522 // ENSGT00420000029845_Domain_0 (256, 274)

DEVSFYANRLTNLVIAMA

ENSGT00420000029845_Linker_0_2 (274, 306)

RKEINEKIHGSENKCIHQSLFMG--D-
-EPT-

PF05716 // ENSGT00420000029845_Domain_2 (306, 1223)

-PHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALGSGQSP-SLRYKSTLKI
KESTKDGKCPDDKPGSKKSFFY-KEVFESRNAGDAKDGGR-SFPGERKIFRG--QDRTDD
FTSSVSQGIMTYANSVVSDMMVSIMKTLRIQVKD--TTIATILLKKVLIKHAKEVVSDLI
DSFMKNLHNVTGSLMTDTDF---------VSAVKRSLFSHGSQKATDIMDAMMGKLYNVM
FAKKFPES-RKAKDKSESYSLI----------SMKSRGGDPR------QPNLNFA-MKSE
SKLR---ES--LFAA--CKPEKEKTCAETLGEHIIKEGLSMWHKTHQKDDCKS-------
--------------PGLDRAAKQG----GP-------HQQEVSFESP-DSCDLSPP--PQ
QPETFENFMCESDTWAKDLIVSALLLIQYHLAQGGRMDAQSFLE--AAAST-----NFPA
NK--------------QPVVHDESRLKS----------PHKICDQEQTEKKDLMSVIFNF
IRNLLSETI-FKGNR-SESKG--QNVKEEEINM-------CERPMTPPAPKFCEDE----
---------------------------ETDGAFSGLTKMVANQLD-----GCMNGQMVEH
LMDSVMKLCLIIAKSCDS--PLAEL-----------------------------------
----------------------------------------GDEKCGDASRPSSAFPDNLY
ECCLPVKGTGTAEALLQTAYQAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQ
AVLQWVAASELNVPILYFAGD-DEGIQEKLLQLSAAAV---EKGRSVGEVLQSVLRYEKE
RQLDEAVGNVTRLQLLDWLMANL--------------