Query Results 

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--------MDSNYFVLFSVHI---------------------------GAVLLSSIQGLA
INVDPVLYTWLIYQPQKRASRHIQQ-----QSVGAVPLGVS-VARKKEDEASVGSAPLAR
QQSNQASEYASSPVKTKTITESRPLSLPVKTMLNSSEGCR-SPEERMKEFIGIVWNAVKR
LTLQLEVQSCCVFLPNDSLPSPSTIVSGDIPGTVRSWYHGQASMPGTLVVCLPQIKIMSA
GHKHMEPLQEIPFVVLRPILEE---GDAFPWTISLHHFSMYTLLGQQMTLNLVEPMGCTS
TLAVTSQKLLASGPESRHSFVVCLHVDLESLEIKCSNPQVQLLYELAEITSKVWNKIQRR
GILYQS--SVYTETMTGPAPPSSPVKSSVGTVPPDTSTYSPSADVGTTTEGDSLQGGDDS
PFSDSITLEQTTSNIGVSSGRVSLWMQWMLPKITIKLFAPDPRNNGT---EVCVVSELED
LSASV--DMQDVYTKIKCKIESFNVDHYRN---------------------------SLG
EDSWSLGQYGGVFLSCTDKLNRRTLLVRPISKQDPFS----NLSGFFPSA--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLISRNER--RTFHKLSEGHTDGSPHFLHEILLSAQAF
DVVLCFPLLNAIASIFQARLPRSQKEKRKTPGQPMRTHTLTSRNLPLIYINTGVIRVFFP
KNEE-DHH-NVEANPAIKEDTLVLKIGSVSMAPQADNPLSRAVLRKDIYQRALNLGILRD
PGSEVEDRQYQIDLQSINIGTAHWNQLKPEKENGKG------------------------
--------------------------------------G---------------------
-------------------------------------------------ILPESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFTVRVTAAPAIIFTKIDAPENLHPEEILVCGHS
LEVNVTTNLDFFLNVAQVQLLQQLVEANMIGLEPSSTINEVSKQEQK-------------
---------------------K-------------------------MDVSDGGMV----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIAQPSR
QSSIVKNLNFIPFDIFVTASRISLMTYSCTALPKLKSPQDQKDGEKISKSSLNLPEAGSG
SSHDTKRPSQPSISSVTADDLLNSNVPLSSGRKTGLLSLETLHASTRSSARQALGITIVR
QPGRRGTGDIELQPFLYLVVSQPSVLLSCHHRKQKIEVSVFDAGLKGVASDYKCTDPGKT
LPEALDYCKI-WLQTVAGEVDAKSGIPPSLITVQIKDFLNGPADVNIDVSKPLKANLSFV
KLDQLKEFLKKIMTTNDNKPG---KETAPSTGTHPDEAVASGAKHSSTKGSPPAVHTSAA
QKVSVQENLWQALSCFQKISIHTVQMVVSMETVPHPSKPC-------LLASL--------
---------SNLSGSLNIKGGLKTAGKRIHGSCLVLDIKDFLLKTCLKERTRSLIGPFCC
SVTVEAKWCKHSGDPGPEQSIPKMYIDLKGGLLQVF-----WGQEHLNCLVLLQELVWEY
LTKTGSAETFVSER-RYRASSSTERNQASKTEHSSDDLRTGLFQYIQD---AEAQKLPGA
YEVVFYNETEDSPGMMLWRYPEPRVLTLVRINPVPFNTTEDPDISTADLGDVLQ------
------------IPCSLEYWDELQKSFVAFREFSLSESKVCELQLPNVSLVNDQKELIAS
DLWRIVLNSNQNVVDDQSS--------ESESGSQSACDQLVTPTALAACTRVDSCFTPWF
VPSVSVLVQFSFLEVHLCHHLDQLGTA---------------------------------
----PPKFLQPFLSDKNMPSELEYMIISFDEPHVYLRQWSDESVFQELQFSTQADCKLLE
CRNVTMQSVVKPFKIWGQIAISGGTGRRLLDCTIMVDPILILFGQYAIHSLNTAIQAWQQ
NQ-CPEAE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDNAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4165)

QQLSGVQKQ
ILICGRQTVCSYLSESIELKVVQHYISQDGQAVVKEHINCLAAKQKLPSYVLEDDELTEL
SVKATGDEDWSQDVCLSSEHTEHSTVIQVPSSKSLITYVWCTILTLEPSSHVQQRIIVFS
PLFIVRSHLPDPIIIHLEKRSLGLNETQVVPGKGQEKALQNIEPDLTHHLTFQAREEDDP
SECAVPISTMLIKQIATKSHPGGNVS-QILSEFYGTANPRQPAWPYNKKDSDSS---EQL
SQWDSPMRVKLSVWKPCVKTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPTGKVMIPP
NFEEAFQVGIYWANTNTVHKSVAIKLVHDVTSPKWKDAENGEVVTLDEEGFVEAEIKLGA
FPGHQKLCQFCISSMVRQGIQILQIEDKTTIINDTSYQIYYRPQLCISKPYS-GEEDFYT
ADSTVFSVGPARTKNTET--LTSVPCWDLLADSSPITSG--TPPTQKRMLLSFSPG---G
SSEFWSLPAVIKQEFPRQSVAVPIGACTESGFYTRAITLTYQEHLGVTYLTLTEDPSPRI
IIHNRCSISLLVKENFK--DTPKFEVYCRKIPAECSIHHELYHQISSYPDCKTRDLLPSI
LLKVMSSDDLVNEWSDIVDINNQGTQVVFLTGFGYVYVDIVHQCGTIIITLAPEGRAGPV
EINLNRSQEQSLFLKVFISQLSLAVFDDITNH-----KVS-SELLRLTADNVFLHMAPTT
SYLRPLSRELQQDTGEG------------LPPFYSLQVYCEDLQLDNQLYSKSNFHFAVL
LCQ-----------GEKNE---TMQWS-RANNLIVSNKDLENYKENCFIKLCIAFSEE--
ENFTFHVNDLSFELKPARLYVEDTFVYYIKTLFDTYLPENK-G-AWQSVNSSV----TTQ
ILPKQVREHARALVKPVKLRKLTI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPENLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQRVSEGQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRSHPNDQQVE-QAPNSHVKYVWKMLQ
SLGKPEVHMALDVMIVSGSGQQHDGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCLEDDQ
QKDLLKVQLKQQRVPCDLEADGVRERLSEQQYNRLVEYVTKTSYHLAPSTTTVPAP--QA
VAAEHLPTVTKTYNYVVDPNFAQVFISKFIMVKNKALRKGFY

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSATENTKSS
VKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGEMEEPTCHNKDM-LGNIT-GAEDETRIDMQYPAQYKGQDL
YSQQEDEQSQGWVSWAWSFVPAIVSYDDGEED---FLGNDPTSTMHQQKAQTLRDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSREVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRALCLKGIMGVKDFEENMNRSETEACFFICGENLSMKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKEIYTEIAGMQRFGAFYMDYLYTMENISGKG--SASQQDFSSGKSEDMGT
-VREKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYGGLKPDIKDENETILNPE
EVASLEEYIPTRHTSITLLKCTFTIFMAEFNLLDHLLPVIMGEKNSSNFLNATNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYAHCYLKIFGFQAGLTSL
DCRGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAVTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVNSLSVNEALMNEVFQT-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSSKWLNESRKPESLL
APDLIAFTVQVPQYMDYCHNSEHGNSVGEGQKEKLRISSRLTAEHGTPGAVLLCSVQGVA
VNIDPVLYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-ISRRKDDEVSVGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSIPVKAMLNLSEGCR-SPEERMKEFIGLVWNAVKS
LTLQLDVQSCCVFVPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGMLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GNAFPWTISLHHFSMYTLFGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVELESLQIKCSNPQVQLLYELTEIMNKVWNKIQRR
GNLSPS--SAYPETMAGPAP-GSPVRSSVGTIPPDTSTCSPSAEVGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGASGRISLWMQWVLPKITIKLFAPDPENKGT---ELCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------RPG
E-GWQSGHFEGVFLQCKEK----------------------------PVT--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTQKEKRKSPGQPMRSHTLTSRSLPLIYINTSVIRIFVP
KIEEMQPS-I-EVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------E----S---G----T---G----G---V----L---T----E---
S----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMIGLEPSSKATEISRQEQK-------------
---------------------K-------------------------TDIFDGSMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCTSIPKSKSQEHK-DNEKTGKSSLNLPEVDS-
---DVAKPSQPCISTVTAEDLLSPSVAFPSGKKLGVISLESLHAATRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLITLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINNLLKKIRSTH----S---KETSAPSDTSLNKDEFPTSKCYRGKFSKSKVHGDGT
QKIPFQENMWRTVSCFQKVSVHTTQIVVSMETVPHPSKPC-------LLASL--------
---------STLSGSLNVKATQKIPGV-ILGSSFLLSINDFLLKTSLKERNRILIGPCCA
SAHLEAKWCKHSGNPGPEQSIPKITIDLRGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEEGNFE--VPEA-VPHMPSPVEKNQMFQSEQSSDDLRTGLFQYIRD---AEPLKMPGV
YEVLFYNETEDSSGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTTDLGDMLQ------
------------IPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVSDQKKLVSS
DLWRIVLNSSQNGTDDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----PPRYLRPFISDKNVPSELEYMIISFKEPHLYLRQWNNSPVCQEIRFSAQADCKLLE
CRNVTMQSVVKPFGIFGQMAVSRDAGEKLLDCSIVVDSVFVSFGQYVVHSLNTAVQAWQQ
NK-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLVIKVQQLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVIREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKSPEYSIVIQVPSSNSSIFYVWCTVLTLEPNSQVQQRLIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEDDP
SHCAVPISTSLIKQIATKIHPGGTVN-QILDDFYGPESSLQPMWPYNKKDSDRS---EQL
SQWDSPMRVKLSVWKPYVRALLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVSLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTIIVNNMPYQIFYKPQFSVSKPQS-GKEYFHV
PDSATFSICPGGEQSAVT--SSSLPCWDLMPDVSQSPLD--TSLLQKQILLAFSPAAGAA
GSPGWSLPAIVRQEFPRQSVAVPLRNRGDNGFCTRAVVLTYQEHCGVTYLTLSEDPSPRI
IFHNRCPVTILIKENIK--DIPKFEVYCRRIPSECSIHHELYHQISSYPDCKTKDLLPSL
FLRVESLEDITSEWSDAIDINNQGTQVVFLTGFGYVYVDIVLQCGTVFITVAPEGKVGSG
LTTTNRTLETIVTLKMFITQLSLVVFDDLTHH-----RVS-SELLRLTLDSVFLHVAPLA
G---ALPGE---EAAAAP-----------VQ-LHCVEVCCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PLLCS-RMQSLLVPSRDLEEYKKNCFIRLSLTLAEGK-
SCFFEDINEFRFELKPARLYVEDTFVYYIKTLFETYLPEGC-L-AAPPAAPGA----GGQ
GLPAQVGQHARALAHPVKLRRLLIQPVSLLVSIHASLKLYIASDHTPLAFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQRTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALEVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCTQDSK
QSNLLTVQLRQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSPMQAP-CPV
VAVEPLPSTVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDAIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
VKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKDGETEDPTCHNKDM-LGNIT-GAEDETRIDMQFPAQYKGQEL
YSQQDDEQPQGWVSWAWSFVPAIVSYDDDEED---YLANDPASTMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMENTGGKG--SVNQQDFSSGKNEDLGT
-VQEKSTKSLVIGPLDFRLDSSSVHRILKMVVCALEHEYEPYNRLKPEIKDESEIILNPE
ELASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLLPIIMGEKNSSNFMNTTNFQPLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLSQPSDNLLHYCYVHCYLKILGFQAGLTSL
DCSGSYCLPVPVIPTFSTALYGKLLKLPTCWTKRSQIVITEGIFELPNLTVQATRAQTLL
LQAIYQSWSH-IGNVSSSGINEALMNEVFQT-VGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKWVPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHNS---------------------------GAVLLCSIQGFA
INIDPIIYTWLIYQPQKRTSRHMQ------QPVVSVPLVTP-ISKRKEDELSVGSAPLAK
QQSYQASEYASSPVKTKTLTESRPLSVPVKTMLNISEGCR-SPEERMKEFIGIVWNAVKS
LTIQLDVQSCCVFIPNDSLPSPSTIVCGDIPGTVRSWYHGQPSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPIIEE---GDAFPWTISLHHFSIYTLLGKQVILCLVEPMGCTS
TLAVTSQKLIATGPDARHSFVVCLHVDLESLEIKCSNPQVQLFYELADTLNKVWNKIQKK
GNLSTS--SAYSETMAGPVP-SSPVRSSVGTVPPDTSTCSPSADIGTTTEGDSIQAGDDS
PFSDSVTLEQTTNNIGGSSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
KECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFEMELPR-QKEKRKSPGQPTRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EMLP-TVGVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESATG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISAENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVTNMTGLEPSYKTTESSKQELK-------------
---------------------K-------------------------MDTFDGGVA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQQSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSITLPKLKS-QEQK-DEKIGKSSLNLPEVDS-
---CAAKPNQACISTVTAENLLSSSTSLTPGRKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLHFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEGLDYSTV-WLQTVPGEIDSKSGIPPSLVTLHIKDFLNGPADISLDISKPLKMNLSFT
KLDQINHFLKKIKNAHSFAHH---KETSTLSYTVLSKDEPPVS-SFHGKLSKPKVHGDGV
HKISFQESTWRTISYFQKISVHTTQIVVSMEPVPHPNKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILVGPFCG
TANLEAKWCKHSGNPSPEQSLPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEEGNFEAQISEP-VSQMP-SMEKNQAFKSEQSSDDLRTGLFQYIQD---AEPLKLPGV
YEVLFYNETEDSPGMMIWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDEIQKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLITPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFHLCHHLDQLGTV---------------------------------
----SPQYLQPFISDRNVPSELEYMIISFREPHMYLRQWNNGSVCQEIRFSAQADCKLLE
CRNVTMQSVVKPFSISGQTEVSSSTAGKLLECTMRVGSVSANFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLSGVQKQ
IIICGRQIICSYLSESIELKVVQHYIGQDGHAVVREHFDCLTPKQKLPSYILENGELTEL
CVKAKGDEDWSRDVCLESKAAEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQITTKIYPGGTVS-QILDDFYGPEKSLEPTWPYNRKDSNRN---EHL
SQWDSPMRVKLSIWKPYVKTLLIELLPWALLINQSEWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDVEIRLGA
F-GHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYHIFYKPQLSVSNPHS-GKEDFHV
PDSATFSICPGREQSAVK--SSSLPCWDLVPDIGLSMLD--ASLLQKQILLGFSPAAGAD
SSQCWSLPAIVTQEFPRQSVAVPFGNFRENGFCTRALALTYQEHFGVTYLTLSEDPSPRV
IVHNRCPVTVLIKENIK--EIPKCEVYCRKIPPESSVHHELYHQISSYPDCKTKDLLPSL
FLKVGLLDAVTAEWSDAVDINSQGTQVVFLTGFGYVYVDIFHQCGTVFITVAPEGKAGPI
LTRTDRTLERMVTFNVFITQFSLAVSDDLTHH-----RAS-SELLRLTLDNVYLHMAPVA
GAFPGE-----E-PTVA------------LFHLYTMEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------EEKAD---PTQCP-RVSNLLVSSRDLEKYKENCFIKLCVTLTEG--
KSFLLNVSELSFELKPARLYVEDTFVYYIKTLFDTYLPHSK-Q-AGHPSQLCG----GTE
VLPVQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHVLAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGTGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDRHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEYEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCTQDSE
QKHLLTVQLKQPRVACDVEVDGVRDRLSEQQYNRLVDYIAKTSCHLAPSCSSTQTP-CSV
VAVEPPPSAVKAYHYLADPHFAQVFVSKFTMVKNKALRRGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCYNKDM-LVNIT-GSEDETRVDIQYPAQYKVQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNNPASTTHQQKAQTLKDPVVSI
GFYCTKATVTFKLTEVQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEEIMNRSETEACFFICGENLNTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENEAMLNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFTNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCCLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSAVNEALINEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLKESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------SVVLLCSVQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAVLNISEGCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNESLPSPSTIVCGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSVYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFCELTDTMNKVWNKIHKR
GNLNLS--SGSPETMAGPIP-TSPVRSSIGTAPPDTSTYSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITVKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIENFNMDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EMQP-TVQVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKENSTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHSEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKASEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSMALSKSKS-QEQKDNEKTGKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLSSSISFPSVKKVGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLITLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINLFLKKIKNAHSSAHS---EETSALPNTMVNKDDLPVSKYYRGKLSKPKVYGDGV
QKISVQENMWRAVSCFQKISVQTTQIVISMETVPHASKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTFVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLMNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFRLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRSMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDAVEKLLDCTMIVDSVFVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENVLLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKTLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVYPEGTVN-QILDEFYGPEKSLQPIWPYNKKDSERN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKFCQFCVSSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPQS-GKEYFHV
PDSATFSVCPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLEKQILLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPFGNCRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLGEVTPEWSDAVDINSQGTQVVFLTGFGYVYVHIVYQCGTVFITVAPEGKAGPI
VTNTNRALEKIVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNVFLRMAPGA
GPLPRE-----E-PVAA------------LFEFYCVEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PMQCS-KMQSLFISNKDLEEYKEKCFIKLCISLSEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYVPNSG-L-AGYSTHLSR----DKQ
VLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPVSLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPITEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQTP-CPV
VAAEPPPSTVKTYHYLVDPHFTQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 105)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGTQ-DDHESC

ENSGT00410000025397_2_Linker_0_1 (105, 3075)

GSNSTNRSTAENTKSS
IKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKDGETEDPPCLSKDT-LGNLT-GTEDESRIDVQYPAPYKGQEL
YSQ-EYEEPQGWVSWAWSFVPAIVSYDDGEED---DLGTDPASIMHQQKAQLLKDPIVSV
GFYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGILGVRDFDEHTNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGAR
ADFILDAAHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKG--PTSQQDFTSGKNEDLGL
-VQEKSTKSLVIGPLDCRLDSSAVHRVLKMIVCALEHEYEPYSRLKPESKDEKEPILAPE
EVSSLEEYIPTRHTSITLLKCTCTIFMAEFNLLDRLLPVIMGGKNSSNFTNATNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLSQPPDNLLHYCYVHCYLKVFGFQAGLTCV
DHSGSYCLPAPIIPSFSTALYGKLLKLPALWAKRSQTVVTEGIFELPNLTIQATRAQTLL
LQAIYQSWFH-VGNVSSSTVNEVLMNEAFQM-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTLGSIKICAKAPGDSGKEKLIPLLQGPSDTRDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHHS---------------------------GAVFLCSVQGLA
VNIDPILYTWVIYQPQKRTSRHAQQ-----QSVVAVPLVTS-VNRRKEDELSIGSAPLGK
QQSYQASEYASSPIKTKTVTESRPVSVPVKAVLHIHEECR-SPEDKMKEFIAILWNAVKS
LTLQLDVQSCCVFIPNDNLPSPSTIVSGDIPGTVRSWYHGQTSIPGTLVLCLPQVKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPVGPDGRHSFVVCLHVDLESLEIKCSNPQVQLIYELTDTMSKVWSKIQKR
GHLSPS--SVYPETVAGPVP-GSPVWSSVGTAPPDTSTCSPSADVGTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATIKLFAPDLEKKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKVESFSIDHYQS---------------------------RPG
-DGWQSGQFEGVFLQCKEKP----------------------------VT--TTKLLDGA
YQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFYKLSEGLMDGSPHFLHEILLSAQAF
DIVVCFPLLNAIASIFHTKIPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETQST-V-AVNQAAKEDTMVLKVGSVAMAPQADNPLGRSVLRKDIYQKALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSGSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------PTESERNSQN
PALEWNMASSIQHHQERRAILTPILTDFSVRITGAPAIIFTKIVSQESLHMEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMSGLEPSTKATEISKQEQK-------------
---------------------K-------------------------VDTFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQYSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKFKLPEQK-EDGKTGRSFLNLTEVDS-
---DVAKPNQVCVSMVTAEDPLSSSTSFSSGKKVRVLSLESLHASTRSSARQALGVTVVR
QPGRRGTGDLELDLFLHLIVSQPSLLLSCHHRKQRMEISIFDAMLKGVPSDYKCTDPGKT
LPEASDYNIV-WLQTVPGETDSKSGIPPSLVTLHIKDFLNGPADINLDVSKPLKANLSFT
KLDQINHFLKKIKKAHSSVHS---KETSTLSDSILNTDEPPVSKCYRGKLSKTKVHCDEA
QKTSFQENMWRAISCFQKVSIHTTQIVVSMETVPHPHKPC-------VLASL--------
---------STLSGSLSVKAAQKVPGA-SLGSSFLLSIHDVLLKTSLKERSRILIGPFSA
AVNLEAKWCKHSGNPGPQQSIPKISMDLRGGLLQVF-----WGQEHLNCLALLHELFSGY
LE-EGKSEMPVPES-APQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQD---AESLKLPGV
YEVLFYNETEESPGMMIWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVYDQKKLVSS
DLWRIVLNNNQNTTDDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFRLCHHLDQLGTA---------------------------------
----SPQYLQPFTSDKNVPSELEYMIISFREPNLHLRQWNSGPVCQEIRFSSQMDCKLLE
CRNVTMQSVVKPFGICGQMALSSDGVQKLLDCTVIVDSVLVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFIVDHVGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4165)

TASLIIKVRPLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLEPKAPEYSTVIQVPTSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGRGQENPLQNVEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQITTKIQPGGTVN-EMLDEFYGPEKSQEPTWPYSKKDSDRN---EQL
SQWDSPMRVKLSIWRPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKTLAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGA
SPGHQKLCQFCISSMVQHGIQVIQIEDKTTVINNTPYQIFYKPYLATSNPYS-GKEHFHV
PDSATFSICPGGEHSAVK--SSSLPCWDIMPDVGSSVLD--TTMLQKQILLGFSPVPGAD
SSQCWSLPAIIKGEFPRQSVAVPFGALRENGFCSRAIALTYQEHLGVTYLTLSEDPSPRV
VFHNRCPVTMLIKENIR--DIPKFEVYCKKIPPESSVHHELYHQIISYPDCKTKDLLPSL
FLRIDSMEEMTAEWSDPVDINSQGTQVVFLTGFGYVYVDITQQCGTVFIILAPEGKAGPI
FTSTSRALERMGTFRVFITQLSLAVSDDLTHQ------AP-SELLRLTLDNVFLHVSPVP
G---VLPGE---EPPSSF-----------FQ-LYGVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GERTD---PAQYS-RVQSLLVSSKALEEYKENCFIKLCLTVSEG--
KDILLDVSEFTFELKPARLYVEDTFVYYIKTLFDTYLPPSR-M-SGHHAQLFT----GRQ
VLPVQVTQHAKALVNAVKLRKLLI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLISIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRCQPTHLYAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSLSEDTQQQAFPITEITCAQDTK
QNNLLTVQLKQPRVACDVEIDGARERLSEQQFKRLVDYIAKTSCHLAPSCSSMQ-T-CSV
VAVEPPPATVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKSS
VKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKDGETDDPSSHNKDI-LGNIT-GAEDENGIDMPYTAQYKAQEL
YSQQDDEQPQGWVSWAWSFVPAIVSYEDGEED---YLVNDPTSDIHQQRAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSDTEACFFICGENLSTKGLTYLTNSLFDYRSPENNAIR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMENTIGKG--SANQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCGLEHEYEPYSRLKPDFKDENETILSPE
EMASLEEYIPTRLTSITLLKCTCTIFMAEFNLLRHLLPVILGEKNSSNFMNTTNFQSLRP
LPSVQILVDKINLEHSVPMYAEHLVHAVSSLTHPSDNLLHYCYAHCYLKIFGFQASLTAL
DYQGSYCLPVPIIPSFSTALYGKLLKLPACWSKRSQVPVTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNDTTSAVNEALMNEVFQTIVGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVRCASGTVGSIKICAKAPGDNGKEKLIPLLQGPSDTKGLHSSKWLYESRKPESLL
APDLIAFTVQLPQYMDYCHSS---------------------------GAVLLCSVQGLA
ANIDPVLYAWLIYQPQKRISRHMQQ-----QPVVAVPLVMP-VSRRKEDEVSVGSAPLAK
QQSYQASEYASSPIKTKTITVNRGLETPLRPGLNVEQGSR-SPEERMKEFIGILWNAVKS
LTMQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIVSA
GHRSMEPLQEIPFVIPRPIIEE---GDAFPWTISVHHFSIYTLLGKQVTLCLVDPMGCTS
TLAVTSQKLLTTGPDARHSFVVCLHVDLESLEIKCSNPQVQLLYELTDTMNKFWNKIQKR
GNLNPS--SAYPESTVGPVP-SSPIRSSVGTAPPDTSTCSPSADMGTTTEGDSVQAGDES
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDPENKGT---VSCFPNHLTQ
FIMSI--ITKSLLVEKSCFFSPSLLLSVTS---------------------------SFG
EEFWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEIFLSAQAF
DIVLFFPLLNAIASIFQAKLPRTQKEKRK-SGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTKEDFQP-NIIINQTANEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESDTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLIESERNSQN
PALEWNMASSIQRHQERRAILTPILTDFSVRITGAPAIIFTKVISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLLVANMTGLEPSNKATEISTQEQK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVQIRIVQIEQPRGTSQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSCTALPKSKS-QEQKDNEKTNKNSLNLPEIGS-
--EDVAKPRHTCISTVTAEDLLSSSISFSSGKKIGVHSLESLHASTRSSARQALGITIVR
QPGRRGTGDSQLEPFLYLIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDSGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLVMLQIKDFLNGPADINLDIAKPLKANMSFT
KLDQINRFLKKIKMAHGFSHS---KVTSALSDSTLNKDELPASKCYPRKLSKPEVHGDGV
QKIPLQENMWRAVSCFQKISVHTTQIVVSMETVPHPNKPC-------LLTSL--------
---------SNLNGSLSVKAGEKVPGM-ILGSSFLLTINDFLLKTSLRERSRVLIGPCCA
TVNLEAEWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNEY
LNKEGDFEVQVSEP-VSQKSFPMEKNQTFKSEQSSDDLRTGLFQYIQD---AELLKLPAV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLSDVLQ------
------------VPCSLEYWDELQKVFVGFREFSLSESKICELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFAPWF
VPSLGISFQFAHLEFHLCHHLDQLGAA---------------------------------
----PPQYLKPFISDKNVPPELEYMIISFREPHLYLRQWNNGPICQEIRFSAQADCKLLE
CRNVTMQSVVKPFSIFGQIAVSSDAVEKLLECTVIVDSIFVNFGQHVVHSLNTALQAWQQ
QRTCVNIWALLVSFHFVVCFKIKFLLLFFLIDCKKSNLLLVILYSFHVAWHMEKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKVQQFSGVQKQ
IIICGRQIICSYLSESIELKVVQHYIGQDGQAVVREHFDCLTTKQKLPSYILENSELTEL
CVKAKGDEDWSRDMCLESKDPEYSIIIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLNETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEDDP
SDCAIPISTALIKQIASKIYPGGTVN-QILEGFYGPEESLQTMWPYNKKDSDRN---EQL
NQWDSPMQVKLSVWKPYIKTLLIELLPWALLINQSKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSIAIKLVHNLTSPKWKDGSNGEVVTLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSLHS-GKEYFHV
PDSATFSICPGGEQPAVK--SSSLPCWDLMPDTCQSELG--ASLLQKQILLSFSPAIGAN
SSQCWSLPAIVRQEFPRQSVAVPFRNCRENGFCTRAIVLTYQEHFGVTYLTLSEDPSPRI
IFHNRCPVTMLIKENIK--DIPKFDIYCRKIPSECSIHHELYHQISNYPDCKTKDLLPGL
LLRVELVDERTNEWSDAIDINNQGTQVLFLTGFGYVYVDIVHQCGTVFITFAPEEKAEPI
LSNTNRTLEKIVTFKMFITQLSLAVFDDLTHH-----KAS-SELLRLTLDNVFLQMAPGA
SHLPGE-----E-TPAA------------LFQLYCMEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PTQCF-KMHSLLVSSKDLEEYKENCFIKFHITLTES--
KSFVFDINEFSFELKPARLYVEDTFVYYIKTLFETYLPKSR-L-ASHSKVLSG----GKQ
ELPLQVRQHARALVNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--IHVLAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4402)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVLAGVGKGL
MGVLTKPVGGAAELVSQTGHGILYGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDSK
QNNLLVMQLKQ-RVACEVEVDGVRERLSEQQYSRLVDYITKTSCHLAPGSSSVQTP-CPV
VTVEPLPSIVKTYHYFVHPHFAQVFISKFNMVKNKALRKGFP

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----MTTNLDFFLSVAQVRLLQQLVQANLIGLEPSDKVTEVSKQEQK-------------
---------------------K-------------------------MDMSDGGAV----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMSYSCTPLPKFKSVQDQKDVEKISKSSLNLPETDSD
GSQETRKLSQACISSVTADDLLNSNSSLPTGRKSGLLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLHLIVSQPSVLLSCHHRKQRVEISVFDAVLKGVTSDYKCTDPGKT
LPEALDYCKV-WLQTVAGEIDAKSGIPPSLVTLQIKDFLNGPADINVAISKPLKANLSFV
KLDQINHFLRKIIRTNDYDTS---KEAAASADSIPIKDGISAPQCSSRKEFLPAISANGE
QMASVQENLWRVLSCFQKISIHTAQMVVSVETMPHLKKPC-------LLASL--------
---------SNLRGNLNVRSGHKTTGV-IHGSSFVLEINDFLLKTSLKGRSRALIGPFCC
SVNVEAKWCKHSGNPGPEQSVPKIHLDLRGGLIQVF-----WGQEHLNCLVLLHELLQEY
LTEQGKREVLISDL-TCQIQSPMEKNQLSKTEHTSDDLRTGLFQYIQD---AEAQKLPSA
YEVVFYNETEDSPGIMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKSFVAFREFSLSESKVCELQLPSVSLVNDQKELVAS
DLWRIVLNSSQNGPDDQSS--------ESESGSQSACDQLVTPTALAACTRVDSCFTAWF
VPSLGVSVQFAHLELHLCHHLDQLGTA---------------------------------
----PPRFLQPFTSDKNVPSELEYMVVSFKEPHIYLRQWSDESVFKEIQFSAWADCKLLE
CRNVTMQNVVKPFKICGQIAISSNTAEKLLDCTVMVDPIFVNFGQYAVHSMNTALQAWQQ
NQ-CPEAE-ELVFSHFVICNDTQETLRFGQVDT-DENVLLASLHCHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDNAGIFIRTIQYKGRTASLIIKIQQLSGVQKQ
IIICGRQMVCSYLADSIELKVVQHYIGQDGQAVIKEHFDCLAAKQKLPSYVLEDDELTEL
SVKAKGDEDWSRDVCLSSKNTEYSTVIQVPSSNSSIIYVWCTILTLEPSTQVQQRIIVFS
PLFIMRSHLPDPIIIHLEKRSLGLRETQMIPGKGQEKSLQNIEPDLTHHLTFQAREEDDP
SECAVPISTALIKQIATKSHASGTVN-QILSEFYGINSSPQPVWPYNRKDSESN---EQL
TQWDSPMRVKLSVWKPCIKTLLIELLPWALLINQSKWDLWLFEGEKIVLQIPAGKTIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNVTSPKWKDADNGEMVTLDEEGFVEAEIKLGA
FPGHKKLCQFCISSMVQHGIQILQIEDKTTVINNTSYHIYCIPQLSVLRPRS-GEEYLHI
PDSTAFRICPAGEPPTEK--LSSVPCWDLMSDISQSTSE--VSLLKKHILLSFSPIVCAD
SLQCWSLPAVIKQEFPRQSVSVPIGVCNESGFCTRAIALTYQEHLGVTYLTLTEDPSPRI
IIHNRCSVSLILKENIK--DTPKFEVYCKKIPAECSVHHELYHQVSSYPDCKTKDLLPSI
LLKVMSSDELTHEWSDFVDINNQGTQIVFLTGFGCVYVDIAHRCGTIIITLAPEGRPGPV
LINLNRTPEQSVIFKMFISQASLAMFDEITNH-----KMS-SELLRLTVDNVYLKMAPVD
SYLRSLSHEFQGEISEG------------LPQFYGLQIYCGDLQLDNQLYNKSNFHFAVL
LCQ-----------GEKNE---TIEWS-KVNNLILSKKDLEEYKENCFIKLCITLSEE--
QNFLFCVNDLSFELKPARLYVEDTFVYYIKTLFDTYLPDNK--VIGHCIK----NSTITQ
ILPEQVRQHAKALVNPVKLRKLAIQPVNLLVSIHASLKLYIASDHTPLSFSEFERGPIYT
TARQL--IHVLAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4404)

EWRRQ
LPENLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKISEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYKQPHKICLENASVSRK-----AR-
----------------GPYGTGCDNCEWIRTRT---------------------------
------------------------------------------------------------
------------------------------------------

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 106)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESSG

ENSGT00410000025397_2_Linker_0_1 (106, 3075)

SNSTNRSATENTKSS
VKPRKIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDSACHNKDM-LGNIT-GAEDETRIDMQYPAQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---YTGNDSTLTIHQQKVQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGDPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEASFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKG--SANQQDFSTGKNEDLGT
-VQEKSTKTLVVGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKPEIKDENETILNPE
EVASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDCLLPLIIGGKNSSNFMNTANFQSLRP
LPSIQILVDKINLEHSVPMYAEHLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DVSGSYCLPVPIIPSFSTALYGKFLKFPTCWTKRSQIVMTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSAVNEILMNEVFQN-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTVQVPQYMDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMPQ-----QPVVAVPLVMP-ISRRKEDELSVGSAPMAK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMFNISEGCR-SPEERMKEFIGIVWSAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGSVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTINLHHFSIYTLIGKQATLSLVEPMGCTS
TLAVTSQKLLATGPDARHSFVVCLHVDLESLEIKCSNPQVQLFCELIDTMKNVWNKIQRR
GNLSSF--SAYSDTVVGPVP-SSPVRSSVGTAPPDASTCSPSADIGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSNGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPVSKQDPFS----NCSGFFPST--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DVVLCFPLLNAITSIFQAKLPRSQKEKRKSPGQPMRTHTLTSRSLPLIYINSSVIRIFVP
KTE-EMKS-TIEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKISSPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSKKATEISKQEQK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDVFITASRISLMTYSCTALPKSKS-QEQKEDEKTGKSSLNLSEVDS-
---DVAKPNQACISMVTAEDLLSSSTSLTSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYNTV-WLQTVPGEIDSKSGIPPSLVMLQIKDFLNGPADINLDISKPLKANLSFT
KLDQMNHFLKKIKSAHGFAHS---KETSTLSDPTLNKDELPVSKCYHGKLSKPKVHADGV
QKFSFQENMWRAISCFQKISVHTTQIVFSMETVPHPNKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLSINDFLLKTSLRERSRILIGPFCA
TTNLEAKWCKHSGNLGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LKEERNVEVLVSEP-VPQMPSPVEKTQAFKSEHSSDDLRTGHFQYIQD---AEPLKLPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGVDDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFHLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIVSFREPHMYFRQWNNGSICQEIRFSAQADCKLLE
CRNVTMQSVVKPFSIFGQIAVSSDAVGKLLDCTLTVDSIFINFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4167)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKASEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLNETQIIPGRGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQIATKIHPGGTVN-QILDEFYGPEKSLEPTWPYIKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPASKTIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEGFIDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTVINNTPYQIFYKPQLSVSKPHS-GKEYFHV
PDSATFSICQGGEQPAIK--SSSLPCWDLMPDVGPSVLD--TSLLQKQILLGFSPATGAD
SSQCWSLPALVKQEFPRQSVAVPLGNSRENGFCTRAIALTYQEHFGVTYLTLSEDPSPRV
ILHNRCPVAVLIKENIK--DIPKFEVYCRKIPSESSVHHELYHQISSYPDCKTKDLLPSL
CLRVELPDEITTEWSDAVDINSQGTQVVFLTGFGYVYVDVFHQCGTVFITVAPEGKAGSI
LTNTNRTLEKTITFRMFITQLSLAVSDDLTHH-----RAS-SELLRLTLDNVFLHMAPVA
GILPGE-----E-PAAA------------LFQLHCVEVYCGDLQLDNQLYNKSNFHFAVL
ICQ-----------GEKTE---PTQCS-KGQSLLASSRDLEEYKENCFIKLRVTLTEG--
KSVPLDVNEFSFELKPARLYVEDTFVYYIKTLFDTYLPHSR-L-AGHPPQLSG----GKQ
VLPLQVRQHARALVNPVKLRRLVIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4310)

VNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCTQDSK
QSSLLTVQLKQPRMACDVEVDGIRERLSEQQYNRLVDYITKTSCHLAPSCSSVQTPS-PV
VAVEPPLSTVKTYHYLVDPHFGQVFISKFTMVKNKALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGAQQEDHESCGSSSTNRSTTESLKSA
VKSRRVQQSASPDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDEFWDRAFMDISATDLVLRKMINFSDCTVCLDKRNASGKIEFYQEPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSISDQQLPMFI
RIMQLGIALYYGEIGNFKDGESEDLICHTKDT-LGNIT-GTEDEASSVMQYPTQYISQDP
YFHQDDDQQQGWVSWAWSFVPAIVSYDDEEND---SGGIGDGTA-EQQKAQSLKDPIISV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVICWEQEGTTVEVLMKGELFFDCQIGFV
GCQAMCLKGIMGIKDFEENMNRSDEEACFFNCGETLSVKGMTYLTNSLFDYRSPENNSIR
AEFILDSAHHKETYTEIAGMQRFGAFYMDYLYTMEST-GKV--SGNQQDLSSVKSEDFGN
-VQEMSTKSIIVGPLNLRLDSSAVHRIMKMIVCALEHEYEPYSKTKPDIMDGSRTMPSSE
EVTSLEEYIPTRLTTFTVLKCTIIIPVAEFNLLDHLLPIIMGEKNLSGLLNAASFQPLRP
LPSIRILVDKVNLEHSVPMYAEQLVHVVSSLGQPSDNLLHYCYSHCYLKIFGFQAALTSL
DNKGLYCIPVPVIPSFSTAVYGKLIKFPKYWTKRAHIPLTECIFELPNLTVQATRAQTLL
LQTIYQSWCHPVGNVSSMVVNEALLNEVFQTSVGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDGGKEKLIPLIQGPSDTRDLHSSKWLNESRKPESLL
APDLVAFTIQIPQYMDYCHNS---------------------------GAVLLSSVQGLA
INVDPVLYTWLIYQPQKRASRHIQQ-----QSVGAVPLGVS-VTRKKEDEASVGSAPLAR
QQSNQASEYASSPVKTKTVTESRPLSLPLKTVLNSSENC-RSPEERMKEFIGIVWNAVKC
LTLQLEVQSCCVFLPNDSLPSPSTIVSGDIPGTVRNWYHGQASMPCTLVVCLPQIKVMSA
GHKHMEPLQEIPFVVLRPILEE---GDAFPWTISLHHFSVYTLLGQQMTLNLVEPMGCTS
TLAVTSQKLLASGPESRHSFVVCLHVDLESLEIKCSNPQVQLLYELAEITSKVWNKIQRK
GVLYQSVSSVYTETMTGPVPPSSPVKSSIGTIPPDTSTYSPSADIGTTTEGDSLQGGDDS
PFSDSITLEQTTSNIGVSSGRVSLWMQWMLPKITVKLFAPDPRNNGTAIAEVCIVSELED
LSASV--DMQDVYTKIKCKIESFNIDHYRN---------------------------SLG
EDSWSLGQYGGVFLSCTDKLNRRTLLVRPISKQDPFS----NFSGFFPST--TAKLLDGS
HQQHG-FLSLTYTKAVTKNVRHKLISRNER--RTFHKLSEGHTDGSPHFLHEILLSAQAF
DVVLCFPLLNAIASIFQARLPRSQKEKRKPPGQPMRTHALTSRNLPLIYINAGVIRVFFP
RNEEDHHV--AEANPSIKEDTLVLKIGSVSMAPQADNPLSRAVLRKDIYQRALNLGILRD
PGSEVEDRQYQIDLQSINIGTAYWNQLKPEKENGKG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFTVRITAAPAIIFTKIDAAENLHPEEILVCGHS
LEVNMTTNLDFFLNVAQVQLLQQLVQANMVGLEASSSTTEVSKQEQK-------------
---------------------K-------------------------MDVADGGTV----
------------------ETSSRYSGAQDSGIGSDSVKIRIIQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFVTASRISLMTYSCTASPKSKSVQDQKDGEKISKSSLNLPETVSG
SSHDTKKPSQPCISSVTADDLLNSNAPLSAGRKAGLLSLESLHASMRSSARQALGITIVR
QPGRRGAGDIELQPFLYLIVSQPSVLLSCHHRKQKVEISVFDAGLKGVASDYKCTDPGKT
LPEALDYCKI-WLQTVAGEVDAKSGIPPPLITVQIKDFLNGPADINVDISKPLKANLSFA
RLDQINQFLKKIVTTNEDVPR---KEAASPAGIIPDEDITLISRHPSTKDFLPAAHTSTV
QKASLQENLWQTLSCFQKISIHTVQMVVLMETIPHPSKPC-------LLVSF--------
---------SNLSGSLNIKSGHKTTGR-IHGSSLVLDIKDFLLKTSLKERAKSLIGPFCC
CVNVEAKWCKHSGDPGPEQSVPKIYIDLRGGLLQVF-----WGQEHLNCLVLLQELLGQY
LTKKSSVETLIPER-TYSTCFSAERNQASKPEHTSDDLRTGLFQYIQD---AEAQKLPNA
YEVVFYNETEDSPGMMLWRYPEPRVLTLVKINPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKSFVAFREFSLSESKVCELQLPSVSLVSDQKELIAS
DLWRIVLNSSQNMADDQSS--------ESESGSQSVCDQLVTPTALAACTRIDSCFTPWF
VPSLSVLIQFTCLEVHLCHHLDQLGTA---------------------------------
----PPKFLQPFLSDKNMPSELEYMIISFDEPHVYLRQWNDESVFQEIQFSTQADCKLLE
CRNVTMQSVVKPFKIWGQIAVSSSTAGRLFDCTIMVDPIFISFGQYALHSLNTAFQAWQQ
NR-CPEAE-EFVFSHFVICNDTQETLRFGQVDT-DENILLATLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDNTGTFIRTIQYKGRTASLIIKVQQLSGVQKQ
ILICGRQTVCSYLSESIELKVVQHYISQDGQAVVKEHINCLAAKQKLPSYILENNELTEL
SVKSTEDEDWSQDVCLSSKHTEHSTVIQVPSSKSSITYVWCTVLTLEPNSHVQQRLIVFS
PLFIVRSHLPDPIILHIEKRSLGLNETQVIPGKGQEKALQNIEPDLTHHLTFQAREEDDP
SECAVPISTTLIKQIVTKSHPGGNVG-QVLSEFYGIASPPQPAWPYNRKDSDSN---EQL
SQWDSPMRVKLSMWKPCVRTLLIELLPWALLINQSKWDLWLFEGEKILLQVPSGKVIIPP
NFEEAFQLGIYWANTNTVHKSVAVKLVHNVTSPKWKDTDNGEVVTLDEEGFVEAEIKLGA
FPGHQKLCEFCISSMVRQGIQILQIEDKTTIINDTSYQIYYKPQLFVSKSHS-GEEAFHC
PDNTVFSISPSAAGPGCREAPSAVPCWDLLWGPGAPAAG--ASLGDRRLVLSFG---STG
SRELWSLPAVVSAELARQSVAVPTGVRAHSGFCTRAIALTYQEHLGVVYLTLTEDPSPRI
IIHNRCPIPLLVKENFK--DTPKFEVYCRKIPAECSVHHELYHQMSSYPDCKTRDLLPSI
LLKVVSSDESENEWSDVVDINNQGTQIVFLTGFGCVYVDITHHCGTIVITLAPEGRAGPV
SINLNRSQEQTLSLKMFISQLSLAAFDDITNH-----KVS-SELLRLTADNVFLHMAPAT
S---SLSQEFQQDSVED------------LPQFHSLQVYCEDLQLDNQLYSKSNFHFAVL
LCQ-----------EEKNE---TAQWS-RMNNLIVCNKDLESYKENCFIKLCIAFSEE--
ENFMFHVNDLSFELKPARLYVEDTFVYYIKTLFDTYLPEN--KTAYKSMN----ASDTTL
IVPEQVREHARALVKPVKLRRLKIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMRNFQQVSEAQASAGHKARGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRSHPSDQHVE-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVMIVSGSGQQHEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCLEDDQ
QKDLLKVQLKQQRVPSDLEAEGTRERLSEQQYSRLVEYITKASCHLSPSTAAAPAP-Q-T
VAAEQPLTITKTYHYVVDPNFAQVFISKFTMVKNKALRKGF-

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSQTEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKVLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSASSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFMP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSLSCFFI------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------RILPFLLQEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVVNMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGV-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LSEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYAEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPLS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLVPAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGRAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KIQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPMQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDLPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
IKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDPPCLSKDT-LGNLT-GTEDESRIDTQYPAPYKGQEL
YSQ-DYEEPQGWVSWAWSFVPAIVSYADGEED---DLGTDPASIMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGILGVKDFEEHMNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKG--PTGQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDCRLDSSAVHRILKMIVCALEHEYEPYSRLKPESKDEKETVLDPE
EVSSLEDYIPTRHTSVTLLKCTCTIFMAEFNLLDRLLPVIMGGKNSSNFTNATNFQSLRP
LPSIQIMVDKINLEHSVPMYAEQLVHVVSSLNQPSDNLLHYCYVHCYLKVFGFQAGLTCL
DHSGSYCLPAPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSPTVNEALMNEVFQM-TGVK-----SKNPQPTLEGSIQNVELKY
CSTSLVKCASGTLGSIKICAKAPGDSGKEKLIPLLQGPSDTRDLHSSKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHHS---------------------------GAVFLCSVQGLA
VNIDPILYTWVIYQPQKRTSRHAQQ-----QPVVAVPLVTS-VNRRKEDELSIGSAPLGK
QQSYQASEYASSPIKTKTVTESRPVSIPVKAVLRVHEECR-SPEDKMKEFIAILWNAVKS
LTLQLDVQSCCVFIPNDNLPSPSTIVSGDIPGTVRSWYHGQTSIPGTLVLCLPQIKITSA
GHKCMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPVGPDGRHSFVVCLHVDLESLEIKCSNPQVQLIYELADTMSKVWSKIQKR
GNLSPS--TVYPETVAGPVP-GSPVWSSVGTAPPDTSTCSPSADIGTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATVKLFAPDLEKKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKVESFSIDHYQS---------------------------RPG
-EGWQSGHFEGVFLQCKEKP----------------------------VT--TTKLLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFYKLSEGLMDGSPHFLHEILLSAQAF
DIVVCFPLLNAIASVFHTKLPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETQST-V-AVNQAAKEDTMVLKVGSVTMAPQADNPLGRSVLRKDIYQKALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSGSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------PTESERNSQN
PALEWNMASSIQRHQERRAILTPILTDFSVRITGAPAIIFTKIISQENLHMEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSTKATEISKHEQK-------------
---------------------K-------------------------VDTFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQYSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKFKLPEQK-EDGKTGRSFLNLEEVDS-
---DVAKPNQVCVSMVTAEDPLSSSTSFSSGKKVRVLSLESLHASTGSSARQALGVTVVR
QPGRRGTGDLELDLFLHLIVSQPSFLLSCHHRKQRVEVSIFDAMIKGVPSDYTCTDPGKT
LPEASDYNIV-WLQTVPGETDSKSGIPPSLVTLHIKDFLNGPADINLDVSKPLKANLSFT
KFDQINHFLKKIKKAHSSAHS---KETSTPSDSVLNTDEPPVPKCYRGKLSKTKVHCDEA
QKTSFQENIWRAISCFQKVSVHTTQIVVSMETIPHPHKPC-------VLASL--------
---------SNLSGSLSVRTAQKVPGA-SLGSSFLLGIHDILLKTSLKERSRILIGPFSA
AVNLEAKWCKHSGNPGPQQSIPKISMDLRGGLLQVF-----WGQEHLNCLALLHELFNGY
LQ-EGKSEMPVPES-APQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQD---AESLKLPGV
YEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVHDQKKLVSS
DLWRIVLNNNQNTTDDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFRLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIISFREPNLHLRQWNSGPVCQEIKFSSQMDCKLLE
CRNVTMQSVVKPFGICGQMALSSDGVQKLLDSTMIVDSVLVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFTVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4165)

TASLIIKVRPLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLEPKASEYSTVIQVPTSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGRGQENPLQNVEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQITTKIQPGGTVS-EMLDEFYGPEKSQEPTWPYSNKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKTLAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQVIQIEDKTTVINNTPYQIFYKPHLAISNAYS-GKEHCHV
PDSATFSICPGGEHPAVR--SSSLPCWDIMPAVGASVLD--TATLQKQILLGFSPVPGAN
STQCWSLPAIIGGEFPRQSVAVPFGTERENGFCTRAIALTYQEHLGVTYLTLSEDPSPRV
VFHNRCPVPILMKENIR--DIPKFDVYCKKIPPESSVHHELYHQIISYPDCKTKDLLPSL
FLRIDSMEEMAAEWSDPVDINSQGTQVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPI
FTSTSRALERMVTFRMFITQLSLAVSDDLTHQ------AP-SELLRLTLDNVFLHVSPVP
A---VLPGE---EPPSSF-----------FQ-LYSVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GERTD---PAQYS-RVQSLLVSSKALEEYKENCFLKLCLTVSEG--
KDILLDVSEFTFELKPARLYVEDTFVYYIKTLFDTYLPPSR-M-SGHHAQLFT----GQQ
VLPVQVTQHAKALVNAVKLRKLLI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLISIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRCQPTHLYAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEINCAQDTK
QNNLLTVQLKQPRVACDVEIDGARERLSEQQFKRLVDYIAKTSCHLAPSCSSMQ-T-CSV
VAVEPPPATVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSVSSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TASPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPRVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKTAQKVPGV-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LSEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTYDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPLS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYEPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMPIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTAENTKSS
IKPRRMQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDLTCHNKDM-LGNIT-GSEDETRIDMQYPAQHKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVALLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNISSSAVIEALINEIFLS-IEIG-----SCYVAQV--------DLEL
LASN----------------DPPTSTS---------------------------------
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M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSVSSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKASQKVPGV-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LSEAGNFEVQVSEP-VPEMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSAYDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTYIRTIQYRGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPLS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPSSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYEPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMPIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCYNKDM-LGNIT-GSEDETRVDIQYPAQYKVQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEVQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEAFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLNTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKG--STNQQDFSSGKSEDLGT
-GQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENEAILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFTNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVPVVSSLTQPSDNLLHYCYVHCCLKIFGFQAGLTSL
NCSGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSAVNEALINEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLKESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------SVVLLCSVQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAVLNISEGCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNESLPSPSTIVCGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTVSLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFCELTDTLNKVWNKIHRR
GNLNLS--SSSPETVAGPVP-TSPVRSSIGTAPPDTSTYSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHSEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKASEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRCSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMPLSKSKS-QEQKDNEKPGKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLSSSISFPSGKKIGILSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVSSDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQINLFLKKIKNAHSLAHG---EETSALPNTMVNKDDLPVSKYYSGKLSKPKVYGDGV
QKISVQENMWRAVSCFQKISVQTTQIVISMETVPHPSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEDGNFEVQVSEP-VPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLMNDQKKLVSS
DLWRIVLNSSQNGADDQRWDDSITLGNNDQSGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFRLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRSMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTMIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENVLLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHSIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGQGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVYPEGTVN-QILDEFYGPEKSLQPIWPYNKKDSERN---EQL
SQWDSPMRVKLSVWKPYVKTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKFCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPQS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--TSLLEKQILLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPFGNCRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTAEWSDAVDINSQGTQVVFLTGFGYVYVDIVYQCGTVFITVAPEGKAGPI
VTNTNRALEKIVTFKMFITQLSLAVFNDLTHH-----KAS-AELLRLTLDSVFLCMAPGA
GPLPRE-----E-PVAA------------LFEFYCVEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PIQCS-KMQSLFISNKDLEEYKEKCFIKLCITLSEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSG-L-AGHSTHLSR----DKQ
VLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPVSLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGGPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPITEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQTS-CSV
VAAEPPPSTVKTYHYLVDPQFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 92)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILK

ENSGT00410000025397_2_Linker_0_1 (92, 3075)

LKDGIQ-VCH-------------------
-----------------S-RYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVSELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYFGEIGSFKDGETEDATCYNKDM-LGNIT-GPEDEKRIDMQFPAQYKGQEL
YSQQDDEQSQGWVSWAWSFVPAIVSYDDAEEN---YLGNDPASTMHQQKAPTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGIKDFEENMNRSEAEASFFICGENLSTKGLTYLTNSLFDYRSPENNGTH
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKGS--SNQQDFSSGKHEDLGI
-VREKSTKSLVIGPLDFRLDSSAVHRILKMVVCALEHEYEPYSRLKPEIKDKNETILNPE
ELASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDYLLPIIMGEKNSSNFMNATNFQTLRP
LPCIQILVDKINLEYSVPMYAEHLVRVVSSLSQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPVIPTFSTALYGKLLKLPTCWTKRSQSVITEGIFELPNLTIQATRAQTLL
LQAIYQSWSR-VGNSSFSGVNEALMNEVFQT-VGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKWIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHSS---------------------------GAVLLCSVQGFA
INIDPILYTWLIYQPQKRASRHMQ------QPVISVPLIMP-SSKRKEDELSVGSAPLAK
QQSYQASEYASSPVKTKTLTESRPLSVPVKAMLNISEACR-SPEERMKEFIGTVWNAVKS
LTIQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIRIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLIATGPDARHSFVVCLHVDLESLEIKCSNPQVQLLYELTDTMSKVWNKIQKR
GNLSTS--SSYSETVPGPVP-SSPVRSSVGTVPPDTSTCSPSADIGTTTEGDSIQAADDS
PFSDSVTLEQTTNNIGGSSGRISLWMQWVLPKITIKLFAPDPENKGT---EVCVVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------RPG
-EGWQSGHFEGVFLQCKEK----------------------------PVT--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RTFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASTFQTKLPR-QKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-AMQP-TVGVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTTQWDQLKPEKESATG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHKLIVANMTGLEPSNKATEISKQELK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQQSGASQHRIARPSR
QSSIIKNLNFIPFDIFITASRISLMTYSSTALPKLKS-QEQKEDEKTGKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLSSSTSLISGRKIGVLSLECLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHKKQRVEISIFDAVLKGVASDYKCTDLGKM
LPEGLDYSTV-WLQTVPGETDSKSGIPPSLITLQIKDFLNGPADISLDISKPLKMNLSFT
KLDQINHFFKKIKNAHSFAHH---KETSALSEMMLNKDEPPVS-SFHGKLSKPKVHGDGV
QKISFQENTWRAISYFQKISVHTTQIVVSMEPVPHPNKPC-------LLASL--------
---------SNLNGNCSVKAAQKVPGI-ILGSSFLLSVNDFLLKTSLKERSRVLIGPFCA
TANLEAKWCKHSGNLSPKQSLPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEERNFEAQVSEP-VSQMP-SWEKNQAFKSEQSSDDLRTGLFQYIQD---AEPLKMPGA
FEVFFHNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------VPCSLEYWDEIQKVFIAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLITPTALAACTRVDSCFTPWF
VPSLCMSLQFAHLEFHLCHHLDQLGTA---------------------------------
----SPQYLQPFISDRNVPSELEYMIISFREPHMYLRQWNNGSVCQEIRFSAQADCKLLE
CRNVTMQSVVKPFSISGQIAVSSDAWGKLLDSTMRVDSVSANFGQHVVHSLNTAIEAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFLICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSDPFSVDHAGTFIRTIQYKGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKIQQLSGVQKQ
IIISGRQIICSYLSESIELKVVQHYIGQDGQAVVREHFDCLTPKKKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKAAEDSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLIHHLTFQAREEYDP
SDCAVPISTALIRQIATKIHPGGTVN-QILDDFYGPEKSLEPTWPYNKKDSERT---EQL
SQWDSPMRVKLSIWKPYIRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDVEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYHIFYKPQLSVSNPHS-GKEDFHV
PDSATFSICPGGEQPAVK--PSSLPCWDLMPDIGPLVLD--ASLLQKQILLGFSSAAGAD
SSQCWSLPAIVTQEFPRQSVAVPFGNFRENGFCTRALALTYQEHFGVTYLTLSEDPSPRV
IVHNRCPMTVLMKENIK--EIPKFEVYCRKIPSESSVHHELYHQISSYPDCKTKDLLPSL
FLRVDLLDPVATEWSDAIDTNSQGTQVVFLTGFGYVYVDIVHQCGTVFITVAPEGKAGPI
LTHTTRTLEKMVTFKVFITQLSVAVSDDLTHH-----RES-SELLRLTLDNIFLHMAPVA
GALPGE------EPAAA------------LFRLYSVEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------EEKAE---PTQCP-RVSHLLVSSRDLEEYKENCFIKLGITLTEG--
KSFLLLVSELSFELKPARLYVEDTFVHYIKTLFHTYLPHRK-P-AGHPSQLCG----GDQ
VLPLQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSLFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGTGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSAAQASAGHKAKGVISGVGKGL
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDQHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSE
QKDLLTVQLRQPRVACDVEVDGVRERLSEQQYNRLVDYIAKTSCHLAPSCSSMQTP-CPV
VAVEPPPSTVKAYHYLVDPHFAQVFISKFTMVKNKALRKGFS

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKSS
VKQRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPAQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTMHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHMVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPHLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALINEIFLS-IEIG-----SCYVAQV--------DLEL
LTSN----------------DPPTSTS---------------------------------
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M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 97)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLE------------
------------------------------------Q-DDHESCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNILINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGDIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
HSQQDEEQPQGWVSWAWSFVPAIVSYDGGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLNFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVNEALINEVFLS-IEIG-----CCYVAQV--------DLEL
LASN----------------DPPTSTS---------------------------------
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----------IRRHQERRAILTPVLTDFSVRITGAPAIIFTRIISPENLHTEETLVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKTTEISKQEQK-------------
---------------------K-------------------------MDTFDGGVA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSTIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKMGKSSLNLPETDS-
---DVAKPNQACISTMTAEDLLSSRISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLFLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINHFLKKIKNSHGFAHS---RETSAQSDSIVNKDELPVSKCYRGKFSKPQVHSDGV
QKMSVQENMWRAVSCFQRISVQTTQIVISMETVPHPSKPC-------LLASL--------
---------SNLNGSLSVKATQKVPGV-ILGSSFLLSINDFLLKTSLKDRSRILIGPCCA
TANLEAKWCKHSGNPGSEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEERNFEVQVSEP-VPQIPSPMEKNQTFKSEQSSDDLRTGLFQYIQD---AESLKLPGI
YEVLFCNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------VPCSLEYWDELQQVFVAFREFSLSESKICELQLPDINLVNDQKKLVSS
DLWRIVLNNSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCLSFQFAHLEFRLCHHLDQLGTA---------------------------------
----TPQYLKPFISDRNVPSELEYMIVSFREPHMYLRQWNNGSVSQEIRLSAQADCRLLE
CRNVTMQSVVKPFSICGQIAVSSDAVEKLLDCTMIVDSIFVNVGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHSGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLMAKQKLPSYILENNELTEL
CVRAKGDEDWSRDVCLESKDPEHSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIVTKIHPGGTVN-QILDEFYGPEKSFQPMWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNSTSPKWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTSYQIFYKPQLSVSSPYS-GQEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ISLFQKQILLGFSPGTGAD
SSQCWSLPAIVRQEFPRQSVAVPFGDFRENEFCTRAIALTYQEHFGVTYLTLSEDPSPRI
IVHNRCPVTMLMKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTRDLLPSL
LLRVELLNEITTEWSDALDINSQGTQVVFLTGFGYVYVDIVHQCGTVFITVAPEGKAGPI
LTNTNRTLEKTVTFKMFITQMSLAVFDDLTHH-----KAS-VELLRLTLDNIFLCLAPGA
GPFPGE-----E-PAAA------------LFELYCVEVYCGDLQLDNQLYSKSNFHFAVL
VCQ-----------GEKTE---PIQCS-KIQSLLISSKDLEEYKENCFIKLCITLSEG--
KSFLCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPSSR-P-AGHSMHVSR----GRQ
VLPELVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYHRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
VGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLRAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVTEDTQQQAFPITEIDCAQDSK
QNNLLTVQLKQPRVACDMEVDGIRERLSEQQYNRLVDYITKTSCHLASSCSSTQAP-CPV
VAVEPPPSTVRTYHYLVDPHFAHIFVSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 105)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGAQQEDHESCGSSSTNRSTTESMKSA
VKPRRVQQSASPDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDEFWDRAFMDISGEYVSSSFVY-----------------------------------
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M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENMKSS
IKPRKIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDELWDRAFMDISATDLVLRKIINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGETEDPTCHSKDM-LGNLT-GAEDETRVDMQFPASYKGQEL
YSQ-DDEQPQGWVSWAWSFVPAIVSYDDEEDD---YLGNDPTSAMHQQKAQTLKDPIISI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQLGFV
GCRAMCLKGIMGVKDFEEHMNRSETEACFFLCGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTDIAGMQRFGAFYMDYLYTMENTGGKG--STNQPDFPSGKNEDLGI
-VQENSTKSLVIGPLDIRLDSSAVHRILKMIVCAFQHEYEPYGRLKPENKDEKETILNPE
EVASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLVPVIMGEKNSSNFMNASNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DHSGSYCVPTPIIPSFSTALYGKFLKLPACWTKRSQLVLGEGIFELPNLTIQATRAQTLL
LQAIYQSWSQ-VGNASSSVVNEALMNEVFQT-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTVQAPHYMDYCHNS---------------------------GAVLLCSVQGLA
INIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVPA-VNRRKEDELSVGSAPLAK
QQSYQASEYASSPIKTKTATESRPLSVPVKAMLNMSEGCR-SPEERMKEFIGILWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSSDIPGTVRSWYHGQTSIPGTLVLCLPQIQIISA
GHKYMEPLQEIPFIIPRPILEE---GDAFPWTISLHHFSIYTLLGKQATLSLVEPMGCTS
TLAVTSQKLLPPGPDVRHSFVVCLHVDLESLEIKCSNPQVQLFYELADTMSKVWNKIQKR
GNLSPS--SVYPETVAGPVP-SSPVRSSVGTAPPDTSTCSPSADIGTTTEGDSIHAGDES
PFSDSVTLEQTTNYIGGASGRVSLWMQWVLPKITIKLFAPDLENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYQS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPVSKQDPFS----NCSGFFPST--TTRLLEGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLLDGSPYFLHEILLSAQAF
DIVLCFPLLNAITSIFQAKLPRTPKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KID-EVHP-TVEVNQAAKEDTMVLKIGSVAMAPQADNPLGRCVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKEGGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------AVTENERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLNVAQVQLLHQLIVANMTGLEPANKATEVSKQEQK-------------
---------------------A-------------------------LDTFEGGVA----
------------------ETSSRYSGAPDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSKTLTKSNS-QEQKEEGKTGKNSSNLSEADL-
----DAKPNQASISTVTAEDLLSSSTSFPLGKKIGALSLESLHASTRSSARQALGITVVR
QPGRRGTGDLQLDPFLFFIVSQPSLLLSCHHRKQRMEISVFDAVLKGVSSDYKCTDPGKT
LPEALDYNTV-WLQTVPGETDSKSGIPPSLVTLQIKDFLNGPADINLDVSKPLKANLSFT
KLDQINHFLRKIKTAHSFAHS---KETSTLSDSTLNKDELAVSRCYRGKLSKPKVHCDGT
QKISVQENMWRAISYFQKISVHTTQIVVSMEPVPHPDKPC-------LLASL--------
---------SNLSGSLSVKAAQKIPGV-ILGSSFLLSINDFLLKTSLKERSRILIGPFCA
TTSLEAKWCKHSGNPGSEHSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELFNGY
LNEEGNFEVQDPET-VPQMPSTLEKHQAFKSEQSSDDLRIGLFQYIQD---AEPLKLPGV
YEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKSFVAFREFSLSESKACELQLPDVNLVSDQKKLVSA
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFHLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIISFKDPHVYLRHWNSGSECQEIRFSSQVDCKLLE
YRNVTMQSVVKPFSIFGQIALSSAEVEKLLDCTMIVDSIFVNFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQHLSGVQRQ
IIICGRQFICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
SVKAKGDEDWSRDVCLEPKASEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQENPLQNIEPDLVHHLTFQAREEYDP
SACAVPVSTALIKQIATKTHPDGTVS-QILDEFYGPEKSREPIWPYNKKDCDRN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGS
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GNQYFHV
PDSATFSICPGGEQPAMK--SSSLLCWDFMPDVGPSVFD--VSLLQKQILLGFSPEPGAD
SSQYWSLPAIIRQEFPRQSVAVPFGTFRENGFCTRAIALTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTILVKENIK--DIPKFEVYCRKIPSESSVHHELYHQISSYPDCKTRDLLPSL
LLRVELLEEITTEWSDAIDINSQGTQVVFLTGFGCVYVDTAHQCGTVFITIAPEGKAGPL
LTNAGRTLEKVVTFKMFMTQLSLAVCDDLTHQ-----KAS-SELLRLTLDNVFLSVAPMA
DSLPGE-----E-PAST------------LFQLYCVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PTHYS-KMQNLLVSSKDLEEYKENCFIKLCITITEG--
KDFLLDVNEFSFELKPARLYVEDTFVYYIKTLFDTYLPRNR-L-AGQDTQLSG----GRQ
VLPVQVRQHARALLNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYTRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGMGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPGDLRAD-QDPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDSK
QSNLLSVQLKQSRVACDVEMDGVRERLSEQQYNRLVDYIAKTSCHLAPSCSSMQAT-CSV
VAMEPPPTTVKTYHYLVDPHFAHVFISKFTMVKNKALRKGFP

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-------------------------------------------MPGTLVLCLPQITILSA
GHKYMEPLQEIPFVVLRPILEE---GDAFPWTISLHHFSVYTLLGQQMTLCLMEPIGCTS
TLAVTSQKLLASGPESKHSFVVCLHVDLESLEIKCSNPQVQLLYELTDTMSQVWNKIQKR
GVLHQS--SVYIESMGGPIP-SSPIRSSVGTAPPDTSTCSPSADIGTTTEGDSLQAGDDS
PFSDSVTLEQTTSNIGVSSGRVSLWMQWVLPKITIKLFAPDPGSKGT---EICVVSELED
LSASV--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQYGGVFLSCTDKLNRRTLLVRPVSKQDPFS----NFSGFFPST--TTKLLDGS
HQQQHGFLSLTYTKAVTKNVRHKLTSRSER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DVVLYFPLLNAIANIFQAKLPRTQKEKRKSSGQPMRTHTLTSRSLPLIYINTGVIRVFFP
KTEESQRT-AKAAHQAAKEDTLVLKIGSVSMTPQADNPLCRTILRKDIYQRALNLGILRD
PGSEVEDRQYQVDLQSINIGTAQWDQLKPEKESGKG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------LTESERNSQN
PALEWNMASSIQRHQERRAILTPILTDFSVRITGAPAIIFTKIISVDNLHIEEILVCGHS
LEVNMTTNLDFFLSVAQVQLLHQLIIANMVGLEPSNQSPEVQSIELTIWGRQTRAMAINR
IKAKLCLPQHLVIIGEQREQRKTRSEKSRITGRRTSCRIREWESSSPPEGFKGGKSGRLL
EFKEVFSDAWPLLWSKGPGFPAASSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSH
QSSIVKNLNFIPFDVFITASRISLMTYSCTAVPKSKPLKDQKDGEKMGKNALNLTEADS-
--DVGTKTGPVSISSVTADDLLSSNISLPTGRKTGLLSLECLRASTRSSARQALGITIVR
QPGRRGTGDVQLEPFLYLVVSQPSLLLSCHHRKQRVELSVFDAMLKGVASDYKCTDPGKI
LPEALDYSKI-WLQTVSGEVDTKSGIPPPLVILQIKDFLNGPEFFEVSPFSKLSINKPCL
LFLESPKLISSLNL-PNYTWSREGKRINIRSESINSVR---RGIPWKGLEETNKHKCTGI
QRSITKLLMVKLTLLMG-A-TDASDVVVVNVSVSHEEEESVDVLPSAIILNLSISSSVII
VMVFVVTVSIHLAPAEDAVIKTKVSRV-ILGSSFLLAINDFLLKTSLKDRSRVLIGPFCG
TANLEAKWCKHSGNPGPDQTIPKVHIDVRGGLIQVF-----WGQENLNCLVLLCELLHGY
LNKDGRSEGRVNDQ-GPQMLLPVEKTQSCKTEHSSDDLRTGLFQYIQD---AEPQKLPGV
YEVIFYNETEDNPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVLALID
QAYVSYYSSQNQVPCSLEYWDELQKGFVAFREFSLSESKVCELPLPSINLVNDQKKLVAS
DLWRIVLNSNQNGVDDQSS--------ESESGSQSACDQLVTPTALAACTRVDSCFTPWF
VPSLGVSLQFAHLEFHLCHHLDQLGTGTLFSEEYIWFDSVFHTNNSCFFFPPYATAVLFS
SFVVPPQYLQPFISDKSVPAELEYMIISFREPHVYLRQWNDGSVCQEVQLSTQADCQLLE
CRNVTMQSVVKPFSIYGQLAVSSGAAEKSLDGTVIVEPVFINIGQYAVHSLNTAIQAWQQ
NK-CPEAE-ELVFGHFVICNDTQETLRFGQVDT-DENILLACLRSHQYSWRSHKSPQALS
LAPMGNMSLQSKKEAVYVEGWSKKAFLPFHHLNSAFLNPKIQFSSVLTAHYSNISVLKCN
GWGGINKLLLHICIEGWGNWRWSEPFSVDSAGTFLRTIQYKGRTASLIIKVQQISGVQKQ
IIFCGRQIICSYLSQSIELKVVQQYMGQDGQAVIKEHLDCLTANQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLEAQNTEYSIVIQVPSSNSSIIYVWCTVLTLEPCSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKSLQNIEPDLMHHLTFQAREEDDP
SDCAVPISTALIKQIATKTHPGGTVN-QILSEFYGTESSFRAVWPYNKKDSERNLCHEQL
SQWDSPMRVKLSVWKPYVKTLLIELLPWALFINQSKWDLWLFEGEEIVLQIPAGKTIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLDHNSTSPKWKDGDNDEVVTLDEEGFVDAEIKLGA
FTGHQKLCQFCISSMVQQGIQILQIEDKTTVINNTPYQIFYKPLLSVSSIRS-EEEYLQV
LDSATFSICPAGDQPTVK--SSSVPCWNLMPDISQSMLE--ESLLQKQILLSFCPAGSAD
SSQGWSLPAVVRQEFPRQSVAVPLRDCTENGFCTRAVALTYQEHLGVTYLTLTEDPSPRL
IIHNRCPIMLLLKENIK--DTPKFDVYCRKIPADRSIHHELYHQVSCYPDCKTKDLLPSL
LLKVVSQDETTPEWSDFVDINNQGMQVLFLTGFGYVYVDVTHHCGTVIITLAPEGKAEPI
LTSTFGSIKSSLIIIIS---SSSSVLIRIHNRDARESAGSYHHLLVVLSNGAFSEVPSFR
A-----EGD---ELDGGWYHVVEYSQESILKKISLDCVACTCRQRDHQETNNSNFRHSTN
TIDRLILEQRKECNAKNSTGIGPNPSKKILHSRLLNNA------QVQFVDNSTSWAR-RT
CQITFQAVLI---NITLRIYPVIFFLAFLLTLFSHCCAAPGMP-SVLETGISGTGKPQAQ
QLSSDLIQSISALARPSRIP--------HPLSLHGSGSCLVLVGDFPLAPSTVTIGRVGC
ATIRSGHPAVWAVLVTFALW--IHTGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPENLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPLGGAAELVSQTGYGILHGAGLSQLPKQRYHPRDQHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVIVSGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEVDCVQDTG
QGNVLKVQLKQQRVACDLEADGVRERLSEQQYNRLVDYITKTSCHVIPSISSVQTQ-FQV
VAVEPPVSTVKTYNYLVDPNFVQVFISKFSMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTSENTKSS
IKPRKVQQSAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFRDCETEDPTCHSKDM-LGNIT-GAEDETRIDMQYPAQYKGQEL
YSQLDDEQPQGWVSWAWSFVPAIVSYDDGEED---YLGHDSTPTMHQQKVQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDATHHKETYTEIAGMQRFGAFYMDYLYTMENTSVKG--ISFFLAYV---------
--------------------------------CLSLKN--RNSLESVEIKDENQTILNPE
EVASLEEYIPTRHTSVTFLKCTCTIFMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSFRP
LPSIQILVDKVNMEHSVPMYAEQLVHMVSSLPQASDNLLHYCYAHCYLKIFGFQAGLTSL
DYNGSYCLPVQIIPSFSTALYGKHLKLPTCWTKQSQIVITEGIFELPNLTIQGTRAQTLM
LQAIYQSWSH-IGNVNSLAVSEALMNEVFQT-TSVK-----SKNPLPTLEGSIQNLELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKLVPLLQGPSDTKDLHSTKWLNETRKPESLL
APDLVAFTIQVPQHMDYCHSS---------------------------GAVLLCSIQGLA
VNLDPILHTWLIYQPQKRTSRHMQQ-----QSVVTVPLVMP-VNRRKEDELSVGSAPLAK
QQSYQASEYASSPVKTKTLTESRPLSVPVKAMLTISEGCR-SPEERMKEFIGMVWNAVKS
LTLQLELQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQCSMPGTLILCLPQIKVISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTINLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLPTGPDVRHSFVVCLHVDLESLEIKCSNPQVQLFYELADTMNKVWNKIQKR
SNLSPS--SVYPETVAGPVP-SSPVRSSVGTAPPDTSTCSPSGDIGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDPEKKNT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGIFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLISRNER--RSFHKFSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTQKEKRKSSGQPMRTHTLTSHNLPLIYINTSVIRIFFP
KTEEIQST-V-GVTPAAFEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------K----S---A----T---G----G---V----L---T----E---
N----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITAAPAIIFTKISSPENLHIEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLMVANMTGLEPSNKATEMSKQEQK-------------
---------------------E-------------------------LDAFDGGIA----
------------------ETWSRYSGAQDSGIGSDSVKIRIVQIEPHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCKALPKLKSQEQK-EGEKTGKSSLNFPEVDS-
---DAAKPDQACISTVTAEDLLSSNTPFPSGKKIGVLSLESLRASTRSSARQALGITIVR
QPGRRGNGDLELEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYSTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINQFLKKIRNAHSFAPS---EETSIVSDTTLNKEEHPVSKCYRGKLSTPKIHGYGI
EKISFQENMWNTISCFQKISVHTTQIVVSMETVPHADKPC-------LLASL--------
---------SNLSGSLNVRAAQKAPGV-ILGVSFLLDINDFLLKTSLRERSRSLIGPFCA
TSSLEAKWCKHSSNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELFSGY
LNEEGNFEVQVCEP-ASQMPSSVEKNQNFKSEQSSDDLRTGLFQYIQD---AEPLKLPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAYREFSLSESKVCDLQLPDINLVNDQKKLVSS
DLWRIVLNNNQNGADDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCSSPWF
VPSLCMSFQFTHMEFHLCHHLDQLGTA---------------------------------
----SPQFLKPFISDKNVPSELEYMIISFREPQMYLRQWSSSSVCQEIRFSAQVDCKLLE
CRNVTLQSVVKPFSVFGQIELSSDAVNKMLDCTMTVDSVFVNFGQHVVHSLNTALQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3233)

HFVICNDTQETLRFGQVDS-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKVQ

ENSGT00410000025397_2_Linker_1_2 (3233, 4166)

QLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLDPKASEDSIVIQVPASDSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTALIRQIATKIHPGGTVN-QILDDFYGPEKFLVPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVILDEEAFVDAEIRLGA
FPGHQKLCQFCISSMIQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GKEYFHV
PDSATFSICPGEEQSAMK--CSSLPCWDFMPDIGSSVWD--VSLLQKQILLGFCPTADAD
SSQCWSLPAIVKQEFPRQSVAVPFGNLRENGFCSRAIALTYQEHFGVTYLTLSEDPSPRV
IFHNRCPVTLLIKENIK--DTPKFEVYCRKIPFESSMHHELYHHISSYPDCRTKDLLPSL
RLRVELLEEITTEWSDAIDINSQGTQVVFLTGFGYVYVDIVHQCGTIFITMVPEGKAGFI
LTNSNRTLEKMITFKMFVTQLSLAISDDLTHP-----RAS-SELLRLTLDNVFLHVAPVA
T---ALSGE---EPVATL-----------FQ-LYSVEVFCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PIQCS-KMQSLLVSSRDLEEYKENCFIKLHITVTDGS-
SFLL-DVHEFSFELKPARLYVEDTFVYYVKTLFETYLPHSR-L-ASHATQLSG----DRQ
VLPPQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4309)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHFHRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-KAPNSHVKYVWKMLQ
SLGRPELHMALDVVLVRGSGQEHEGCLLLTTEVLFVVSISEDTQQQAFPVTEIDCAQDSK
QSNILTVQLKQTRVACDMEVDGVRERLSEQQYNRLVDYIAKSSCHMAPSCSSIQVP-CPV
TAVEPPPSTVKTYNYLADPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAESTKSS
IKPRRMQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYENLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDLTCHNKDM-LGNIT-GSEDETRIDMQYPAQHKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTMHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVALLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALINEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHNFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWNKIQKR
GNLNLS--PTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEES
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFIP
KTE-EMQP-TVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWHQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VVTETERNSQN
PALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDIFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKNNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQINLFLKKIKNAHSLAHS---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKATQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNLGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPGGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHS-GKEYFRV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVKMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVEPLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVHQCGTVFITVAPEGKAGPI
LTNTNRAPEKIVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNIFLCVAPGA
GPLPGE-----E-PVAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKEKCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
VLPMQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLDILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNILINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGDIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
HSQQDEEQPQGWVSWAWSFVPAIVSYDGGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLNFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVNEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKR
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRLILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWKKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLKETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKLGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLVSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKTLVSS
DLWRIVLNSSQNGADDQSS--------TSESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHIYLRQWNNGCVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQRLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLDSKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPHS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKHIMLSFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNLRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYYKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLRITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGETEDPTCHSKDV-LGNIT-GTEDETRIDIQYPAQYRGQEL
YSQ-DDEEPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPTSTMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEEHMNRSEAEACFFICGENLSTKGLTYLTNSLFDYRSPENNSTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMEHSSGKG--SSNQQDFPSGKNEDLGI
-VQEKSTKNLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKPESKDEKETVLNPE
EVASLEEYSPTRHTSITVLKCTCTIFLAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSNLTQPSDNLLHYCYVHCYLKVFGFQAGLTSL
DCSGAYCLPTPIIPSFSTALYGKLLRFPTLWTKRSQNVLTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSTVNEALMNEVFQT-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDNGKEKLIPLFQGPSDTKDLHSTKWLNESRKPESLL
APDLLAFTVQVPQYMDYCHHS---------------------------GAVFLCSVQGIA
VNIDPVLYTWITYQPQKRASRHMQQ-----QAVVAVPPLVPSVNKRREDELSVGSAPVAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLHVPEGCR-SPEERMKEFIGILWNAVKS
LTLQLEVHSCCVFIPNDNLPSPSTIVSGDIPGTVRSWYHGQTSIPGTLVFCFPQIKIISA
GHKCMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQRTLSLVEPMGCTS
TLAVTSQKLLPMGPDVRHSFVVCLHVDLESLEIKCSNPQVQLLYELADTMSKVWNKIQKR
GTLSPS--SVYPDT-AGPVP-GSPVRSSVGTALPDTSTCSPSADIGTTTEGDSMQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKVTIKLFAPDLENKGT---GTGVFF----
-------VSIDVFANVKCKIES--------------------------------------
CDCWSLGQCGGVFLSCTDKLNRRTLLVRPVSKQDPFS----NCSAFFPST--TTKLLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KSDEIQPT-V-EVNQAAKEDTMVLKVGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------E----S---G----T---G----G---V----L---T----E---
S----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISSENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLNPSNKTTEISKQEQK-------------
---------------------K-------------------------MDTFDGGIA----
------------------ETSSWYSGAPDSGIGSDSVKIRIVQIERHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSLALPKSKSPEQN-VDGKTGKSSLNLSEVDS-
---DVAKPNQVCISTVTAEDILNG-PTFPSGKKIRVFSLESLHASTRSSARQALGITIVR
QPGRKGTGDLQLDPFLYFIVSQPSLLLSCHHRKQRVEISVFDAVLKGVASDYKCTDPGKT
LPEALDYNTV-WLQTVPGETDDKSGIPPSLVTLQIKDFLNGTADINLDVSKPLKANLSFT
KLEQINHFLKKIKNAHSSAPS---RETSALSETTVNKDEPSISRSYRGKFSKSRIHCDGV
QKISFQENMWRAISCFQKISVRTTQIVISMETVPHLNKPC-------LLASL--------
---------SNLNGSLNVNAAQKVPGI-ILGSSFDLSINDLLLKTSLKERSRILIGPFAT
TAHLEAKWCKHSGNPDLEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELFSGY
LNEEGNYKVQVPEA-VPQMPSPAEKNQAFKSEQSSDDLRTGLFQYIQD---AEPLKLPGV
YEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVTFQEFSLSESKVCDLQLPDINLVSDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPALCMAFQFAHLEIHLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIISFREPHLYLRQWNSGPFCQEIRFSCQVDCKLLE
CRNVTMQSVVKPFSILGQVTLCSDGVQKLLDSSMIIDSVFVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3225)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHTGTFIRTIQYKGRT

ENSGT00410000025397_2_Linker_1_2 (3225, 4167)

ASLIIKVQPLSGVQKQ
IIICGRQVICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENCELTEL
CVKAKGDEDWSRDVCLDPKASKYSLVIQVPASNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQENPLQNIEPDLVHHLTFQAREEYDP
SDCAIPISTALIKQITTKIQPEGTVN-QILDEFYGPEKPLELIWPYNKKESDRN---EQL
SQWDSPMRVKLSVWKPYVQTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGHGEVVILDEEAFVDAEIRLGA
FPGHRKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GKERFHV
PDSATFSICPGGEQLAMK--SSSLPCWDFMPNVGPSGLD--VSMLQKQILLGFSPAPGSN
SSQCWSLPAIVKQEFPRQSVAVPFGTFQENGFCTRAIALTYQEHFGVTYLTLSEDLSPRV
IFHNRCPVTVLIKENIK--DIPKFEVYCRKIPSGSSVHHELYHQIASYPDCKTKDLLPSL
CLRVELLEEMATEWGDAVDINSQGTQVVFLTGFGYVYVDIVHQSGTIFITIGPEGKAGPI
LTNTNRALE--ITFNMFITQLSLAMSDDLTHH-----KAS-SELLRLTLDNIFLHVAPVA
G---ALSGE---EPTSAL-----------FQ-LYCVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GDKTE---PTQYS-KMQSLLVSSKDLEDYKENCFIKLYITISEGR-
DVLL-NVNEFSFELKPARLYVEDTFVYYIKTLLDTYLPHSR-L-TTHYTQLSG----GKQ
AIPMQVRQHARALVNPVKLRKLIIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4310)

VSLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTASFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQTSAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPRDLRAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHESCLLLTSEVLFVVSISEDTQQQAFPITEIDCVQDSK
QNNLLTVQLKQPRVACDMEMDGVRERLSEQQYNRLVDYIAKTSCHLAPSCSSMQTL-CSV
VAVEPPSATVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
IKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDPPCLSKDT-LANLT-GTEEESRIDMQYPAPYKGQEL
YSQ-DYEEPQGWVSWAWSFVPAIVSYDDGEED---DLGTDPASIMHQQKAQKLKDPIVSV
GFYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGILGVKDFEEHMNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKG--PTSQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDCRLDSSAVHRVLKMIVCALEHEYEPYSRLKPESKDEKETVLDPE
EVSSLEEYIPTRHTSITLLKCTCTVFMAEFNLLDHLLPVIMGGKNLSNFTNATNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLNQPSDNLLHYCYVHCYLKVFGFQAGLTCL
DHSGSYCLPAPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSTVNEALMNEVFPM-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVRCASGTLGSIKMCAKAPGDSGKEKLIPLLQGPSDTRDLHSSKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHHS---------------------------GAVFLCSVQGLA
VNIDPILYTWVIYQPQKRTSRHAQQ-----QPVVAVPLVTS-VNRRKEDELSIGSAPLGK
QQSYQASEYASSPIKTKTVTESRPVSVPVKAVLRVHEECR-SPEDKMKEFIAILWNAVKS
LTLQLDVQSCCVFIPNDNLPSPSTIVSGDIPGTVRSWYHGQISIPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPVGPDGRHSFVVCLHVDLESLEIKCSNPQVQLIYELADTMSKVWSKIQKR
GNLSPS--SVYPETMAGPVP-GSPVWSSVGTAPPDTSTCSPSADIGTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATVKLFAPDLEKKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKVESFSIDHYQS---------------------------RPG
-EGWQSGHFEGVFLQCKEKP----------------------------VT--TTKLLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFYKLSEGLMDGSPHFLHEILLSAQAF
DIVVCFPLLNAIASVFHTKLPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETQST-V-AVNQAAKEDTMVLKVGSIAMAPQADNPLGRSVLRKDIYQKALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSGSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------PTESERNSQN
PALEWNMASSIQRHQERRAILTPILTDFSVRITGAPAIIFTKIISQENLHMEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSTKATEISKQEQK-------------
---------------------K-------------------------VDTFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQYSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKFKLPEQK-EDGKTGRTFLNLTEVDS-
---DVAKPNQACVSMVTAEDPLSSSTSFSSGKKVRVLSLESLHASTRSSARQALGVTVVR
QPGRRGTGDLELDLFLHLIVSQPSLLLSCHHRKQRVEVSIFDAMLKGVPSDYTCTDPGKT
LPEASDYNIV-WLQTVPGETDSKSGIPPSLVTLHIKDFLNGPADIYLDVSKPLKANLSFT
KLDQINHFLKKIKKAHSSAHS---KETATPSDSILNMDEPPVPKCYRGKLSKTKVHCDEA
QKTSFQENIWRAISCFQKVSVHTTQIVVSMETVPHPHKPC-------VLASL--------
---------SNLNGSLTVKAAQKVPGA-SLGSSFLLSVHDVLLKTSLKERSRILIGPFSA
TVNLEAKWCKHSGNPGPQQSIPKISMDLRGGLLQVF-----WGQEHLNCLALLHELFNGY
LQ-EGKSEMPVPES-APQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQD---AESLKLPGV
YEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCGLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVHDQKKLVSS
DLWRIVLNNNQNTTDDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFRLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIISFREPNLHLRQWNSGPVCQEIKFSSQMDCKLLE
CRNVTMQTVVKPFGICGQMALSSDGVQKLLDSTVIVDSVLVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3225)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFTVDHAGTFIRTIQYKGRT

ENSGT00410000025397_2_Linker_1_2 (3225, 4165)

ASLIIKVRALSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLEPKASEYSTVIQVPTSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGRGQENPLQNVEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQIATKIQPGGTVN-EMLDEFYGPEKSQEPTWPYSNKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWENTNTVHKTLAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQVIQIEDKTTVINNTPYQIFYKPHLAISNSYS-GKEHCHV
PDSATFSICPGGEHPAVR--SSSLPCWDVTPAVGSSELD--TATLQKQILLGFSPVPGAD
SAQCWSLPAIIGGEFPRQSVAVPFGTGRENGFCTRAIALTYQEHLGVTYITLSEDPSPRV
VFHNRCPVPMLMKENIR--DIPKFDVYCKKIPPESSVHHELYHQIISYPDCKTKDLLPSL
FLRIDSMEEMTAEWSDPVDINSQGTQVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPI
FTSTSRALERMVTFRMFITQLSLAVSDDLTHQ------AP-SELLRLTLDNVFLHVSPVP
A---LLPGE---EPPSSF-----------FQ-LYGVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GERTD---PAQYS-RVQSLLVSSKALEEYKENCFIKLCLTVSEG--
KDILLDVSEFTFELKPARLYVEDTFVYYIKTLFDTYLPPSR-M-SGHHAQLFT----GQQ
VLPVQVTQHAKALVNAVKLRKLLI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLISIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSESQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRCQPTHLYAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEINCAQDTK
QNNLLTVQLKQPRVACDVEIDGARERLSEQQFKRLVDYIAKTSCHLAPSCSSMQ-T-CSV
VAVEPPPATVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFS

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGLQ-DDHESCGSSSTNRSASENIKSS
VKPRRIQQATPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDEFWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGVALYYGEIGNFKDGETEDLSCHTKDI-LGSIS-GGEGETGIEIQYPTQYKAQEF
YAQQDDEQSQGWVSWAWSFVPAIVSYDDGVDD---YLGNDTISALHQQKSQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVICWEQEGTTVEALMMGDPFFDCQIGFV
GCRAMCLKGIMGVKDFEENINRYDAEACFFLCGENLSTKGLTYLTNSLFDYRSPENNGIR
AEFILNAAHHKETYTEIAGMQRFGAFYMDYLYTMESSSGKG--TRNQQDLPSSKSEDLGN
-VQEMSTKSLVVGPLDLRLDSSAIHRILKMIVCALEHEYEPYSKIKPDVGDETRTIPNTE
EVASLEEYIPTRLTCVTILKCTVTVFMAEFNLLGHLLPVIMGEKNSSSFMNSTNFQPLRP
LPCIQILVDKINLEHSVPMYAEQLVHTVSSLSQPSDNLLHNCYAHCYLKIFGFQAGLTFW
DSKGTYCLPVPLIPSFSIAIYGKLLKLPMYWTKRSQVPITECIFELPNLTIQATRAQTLL
LQAIYQSWSH-TGGIGTSVVNEALMSDIFQT-SGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPGENGKEKLIPLIQGPSDTKDLHNSKWLNESRKPESLL
APDLITFTMQIPQSVDYCHNS---------------------------GAVLLASVQGIA
ASIDPVLYTWLVYQPQKRSSRHIQQ-----QSMGAVPHVMP-VTRKKEDEVSIGSMPLAK
QQSNQASEYASSPVKTKTVTESRPLSVPVKAVMSISETCR-SPEERMKEFIGIIWNAVKR
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVILRPILEE---GNAFPWTISLYHFSIYTLLGHQMTLGLVQPMGCTS
TLAVTSQKLLAVGPEARHSFVVCLHVDLESLEIKCSNPQVQLLYELTDIMNKVWNKIQKK
GILNQS--SGYPESVAGLVP-SSPIRSSVGTVPPDTSTCSPSADIGTTTEGDSVQAGDDS
PFSDSITLEQTTSSIGGSSGRVSLWMQWVLPKITIKLFAPDPGNKGR---EVCVVSELED
LSASV--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQYGGVFLSCTDKLNRRTLLVRPVCKQDPFS----NFSGFFPST--TSKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRSDR--KSFHKLCEGLTDGSPHFLHEILLSAQAF
DVVLCFPLLNAIASIFQAKLPRTQQVKRKSPGQPMRIHTLTSRNLPLIYINTSIIRVFFP
KAEEVQPT-A-GVTEAAKEDTLVLKIGSVAMAPQADNPLSRTVLRKDIYQRALNLGILRD
PGSEVEDRQYQIDLQSINIGTAQWEQLKPEKESIKG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------LTENERNSQN
PALEWNMASSIQRHQERRAILTPILTDFTVRITGAPAIIFTKIISSENSHTEEILVCGHS
LEVNITTSLDFFLSVAQVQLLHQLIVVNMVGLEPSNKTTEISKQEQK-------------
---------------------N-------------------------MDPSDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQRSGASQHRIARPSH
QSSIVKNLNFIPFDIFVTASRISLMTYSCTALPKVKAQDQNDS-EKVSKNSFNLPTTES-
--EDVPRPSHTCISKVTADDLVSNSISFPSGRKMGLLSLENLHSSTRSSARQALGITIVR
QPGRRGAGDLQLDPFVYLVVSQPSLLLSCHHRKQRVEMSIFDAVLKGVASSYRCTDPGKT
LPEALDYSKI-WLQTVAGEIDTKSGIPPSLIVLQIKDFLNGPADVNLDISKPLKANLSFV
KLDQINHFLKKITNANGSEGS---TETSALSDTVLTKDELLASKCSHGKSSVPVGHADGV
QKVS-SENMWRAVSYFQKISVHTAQIVVSMETIPHPKKPC-------LLASL--------
---------SSLSGSLNVKAGQRTPGV-ILGSSLLLNINDFLLKTSLKEKNRVLIGPCCS
TVNLEAKWCKHSGNPGPEQSIPKVFIDLRGGLIQVF-----WGQEHLNCLVLLHELLYEY
LNNEGKSEIPTPDQ-ILSMPYPVEKNQTFKTEQSSDDLRTGLFQYIQD---AESLKLPGV
YEVVFYNETEDNPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKTFVAFREFSLSESKVYELQLPDINLVNDQKKLVAS
DLWRIVLNSNQNGADDQSS--------ESESGSQSACDQLVTPTALAACTRVDSCFTPWF
VPSLAVSLQFAHLEFHFCHHLDQLGTV---------------------------------
----SPQYLQPFISDKNVPAELEYMILSFREPRIYLRQWNDGSVCQEFQFSTQADCKLLE
CRNVTMQSVVKPFSIYGQIAVSSEAAEQLLDCTVIVDSIFVNLGQHAVHSLNTAVQAWQQ
NQ-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDSAGTFIRTIQYKGRTASLIIKVQPLGGVQRQ
IIICGRQIICSYLDQNIELKVVQHLMGPDGQAVVREHLDILTGKHKLPSYILENNELTEL
CVKAKGDEAWSRDMCLEDKSTDYSMVIQVPSSNGSIIYVWCTVLTLEPNSQVEQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGQGQEKSLQNIEPDLVHHLTFQAREEEDP
SDCAVPISTALIKQIATKTHPEGPVN-QILSEFYGPENAPQPVWPYNKKDADSN---EQL
SQWDSPMQVKLSVWKPYVKTLLVELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQVGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGSGEVVILDEEGYIGLEIRLGA
FPGHQKLCQFCISSMVRQGIQILQIEDETIITNDTPYQIFCKPQLTVPSPCY-GEEFLHV
PDSATFSLSPGRPQPAME--TSSLPCWDLMPDIGPSTLE--MSLLQKQILLSFCPAVGVD
GAQCWSLPAVVRPEFPRQSVAVPIGNCSRNGFSTRAIALTHQQYFGVTYLTLTEDPTPRI
ILHNKCPVTMLMRENIK--DTPKFQVFCRKIPAECSVHHELYHQISSYPDCRTKDLLPSL
LLKVVPLDDITTEWSDFIDINNQGTQVLFLTGFGCVYVDITHECGTIIITMAPEGKAGPI
LTNANRILGKSVRLKVFITQSSLAVFDDLTHH-----KTS-SELLRLTLDNIFLNMEPVA
SYLRALPLE---GTTAGL-----------PQ-LYSLEVFCGDFQLDNQLYNKSNFHFPVL
VCQ-----------GEKME---TLQWS-KMHNLLISSKDLEDYKENCFIKLCITLSE--K
QNFLFDMNEFSFEMKPARLYVEDTFVYYIKTLFDTYLPNSQ-V-ASHSKRLSG----LPA
LVPEQVRQHAKALVNPVKLRKLAIQPVHLSVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--AHTLAMHYAAGAL--FRAGWVVGSLEILGSPAGLVRSIGNGIDDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPENLGEGLRQGLSRLGLSLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPQQRYYPRDEHAD-RAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVSGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPITEVDCVQDGQ
QRNLLKVQLKQPRVPCDPEVDGARERLSEQQYNRLVDYITKTSCHLAPNSSSMQTP-CPI
VAVEPLPSTVKTYHYLVDPSFAHVFISKFTLVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
IKPRRVQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISAADLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPAVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGEAEDPACHSKDA-LGNIA-GTEDETRIDMQYPAQYKGQEL
LSQ-DYEEPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPVSTLLQQKVQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGESFFDCQIGFV
GCRAMCLKGIMGVRDFEEHMNRTETESCFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAALHKETYTEVAGMQRFGAFYMDYLYTVEHSRGKG--PANQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMVVCALEHEYEPYSRLKPEGKDEKEAAVTSE
DVAALEEYIPTRHTSVTLLRCTCTVSMAEFNLLDRLLPVIAGGKNSSNFMNATNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVRVVSSLTQPSDNLLHYCYVHCYLKVFGFQAGLTSL
NHSGSYCLPVPIIPSFSTALYGKLLKLPTLWTKRSQTVVTEGIFELPHLTIQATRAQTLL
LQAIYQSWSH-AGNASSSTVNEALMTEVFQT-AGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVRCASGTMGSIKICARAPGDSGKEKLVPLLQGPSDTRDLHGTKWLNESRKPESLL
APDLIAFTVQVPQDMDDCHHS---------------------------GAVFLCSVQGLA
VNIDPILYTWVIYQPQKRTSRHMQQ-----QPVVAVPLVPS-VNRRKEEELSVGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLHIHEGCR-SPEERMKEFIGILWNAVKS
LTLQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSTPGTIVLCLPQIKIISA
GHKCMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLFPPGPDGRHSFVVCLHVDLESLEIKCSNPQVQLFCELADTMSKAWSRIQKR
GHLSSS--SVCSESTAGPGP-GSPVRSSVGTVPPDTSTCSPSADMVTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWMLPKVTVKLFAPDCENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYQS---------------------------SHG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPVSKQDPFR----NCPAFFPST--TTKLLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLCFPLLNAISSIFQTKLPRTQKENRKSSGQPMRTHTLTARNLPLIYVNTSVIRIFVP
QTEETQST-V-EVNRAAQEDTVVLKVGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSISIGTAQWGQLKPERGNGSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------LTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAITFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSSKATEICKQEQK-------------
---------------------K-------------------------MDTFDGGVT----
------------------ETSSRYSGAQDSGIGSDSVQIRIVQIEQYSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKFKSPEQK-EDGKTGKNSLNLPEVDS-
---DTAQPDQTCISMVTAEDLLNRSNSFSSGRKVRVLSLESLHASTRSSARQALGGTVVR
QPGRRGTGDFELHPFLYLIVSQPSLLLSCHHRKQRVEISVFDAMLKGAASDYKCTDHGKT
LPEALDYNTV-WLQTVPGETDSKSGIPPSLVTLQIKDFLNGPADINLDASKPLKANLSFT
KLDQIHHFLKKIKKAHSFAHS---KETSAPPDPVLNKDEPPTSKCYRGKLSTPKVHCDGA
QKTSFQENLWRAISCFQKVSVHTTQIVVSMETVPHPHTPC-------VLASL--------
---------SNLNGSLSVKAAQRAPGP-SLGSSVLLSISDFLLKTSLRERSRILMGPFSA
TVHLEAKWCKHSGNPGPQQSIPKVAMDLRGGLLQVF-----WGQEHLNCLALLHELFSGY
LKEERKFEVPVPES-VPQMPSPVDKTQAFKSEHSSDDLRTGIFQYIQD---AEPLKLPGT
YEVLFYSETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVSDQKKLVSS
DLWRIVLNNNQNATDDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFSPWF
VPALCMAFRFAQLEFRLCHHLDQLGTA---------------------------------
----SPQHLQPFIPDKNVPSELEYMVISFKEPNLYLRQWNGDSVCQEIRFSSQVDCKLLE
CRNVTMQSVVTPFSISGQMAVSSDGVQKLLDGTVMVDSVLVNFGQHAVHSLHTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4167)

TASLIIKVHPLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYLGQDGQAVVREHFDCLTARQKLPSYILENGELTEL
CVKAKGDEDWSRDVCLDPKASEYSTVIQVPTSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQENVLKNAEPDLAHHLTFQAREEYDP
SDCAVPISTALIKQITTKIQPGGTVN-QMLDDFYGPEKSHEPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDSGNGEVVTLDEEAFVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQIIQIEDKTTVINNTPYQIFYKPQLSVSNPCS-GKEYFHV
PDCATFSVCPGGEHPAMK--SSSLPCWDFMPDVGPSV-D--TAVLQKQILLGFSPAPGAD
SSPCWSLPAVIRREFPRQSIAVPFGALRENGFCTRALALTYQEHFGITYLTISEDPSPRV
VLHSRCPVPILIKENIR--DIPKFEVYCKKIPPESSVHHELYHQTISYPDCKTKDLLPSL
LLRAEVTEEGTAEWSDAVDMNSQGTQVVFLTGFGYVYVDIAHQCGRVLITIAPEGKAGPV
LGSTNRALQKTTTFKMFITRLSLAVSDDLTHH-----RAS-TELLRLTLDNVFLHVYPVP
G---ELPGE---EPPSTL-----------LQ-LFSVEVYFGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTA---PAQSS-RVQSLLLSTKDLEGYKENCFIKLRLTGAEG--
TDFLFDVSEFSFELKPARLYVEDTFVYYIKTLFDTYLPRSR-V-AGRHAELSA----GRQ
VLPLQVRQHARALVNPVKLRKLVIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4310)

VSLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPRDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDTK
QNNLLTVQLKQPRVACDVEVDGARERLSEQQFNRLVDYIAKTSCHLAPSCSSMQTS-CSV
VAVEPPPATVRTYHYLADPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDLTCHNKDM-LGNIT----------------------
------------------------------------------------------------
------------LTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSAALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALINEIFLS-IGVK-----SKNPLPTLEGSIQNAELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHNFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--STSPETMAGPVP-ASPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEES
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VVTETERNSQN
PALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDIFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKNNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQINLFLKKIKNAHSLAHS---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKATQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVAEKLLDCTVIVDSVFVNLGQHVVHSLNTAIEAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPGGTVN-QILDEFYGPEKLLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPHS-GKEYFRV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVKMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVEPLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVHQCGTIFITVAPEGKAGPI
LTNTNRAPEKTVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNIFLCVAPGA
GPLPGE-----E-PVAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKEKCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPN-R-L-AGHSTHLSG----GKQ
VLPMQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTAENTKSS
IKLRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPAQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FGGNDPASTMHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALDHEYEPYSRLKSDIKDENETILNPE
EVSFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALISEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGS-KICAKGPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLMAFTIQVPQYINYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTGRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVVPRPILEE---GDAFPWTINLHNFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--STSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------RPG
E-GWQSGHFEGVFLQCKEKS----------------------------VT--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFIP
KTE-EMQP-TVEVNRAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VVKETERNSQN
PALEWNMASSIRRHQERRAILTPILTEFSVRITGAPAVIFTKVVSPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDIFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKNNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQINLFLKKIKNAHSSAHS---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKATQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPLEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNAADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNIGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
------------------------------------------------------------
IIICGRQVICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPGGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPHVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKVIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRA
IIHNRCPVKMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDIVHQCGTIFITVAPEGKAGPI
LTNTNRAPEKIVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNVFLCVAPGA
GPFPGE-----E-PVAT------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKEKCFIKLRITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
VLPVQVTQHARALVNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGVQ-DDHESCGSSSTNRSTSESTKTS
VKPRRIQQA-TPDPDLPP-GYVQSLIWRVINNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVNEFWDQAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKIHTLVESLKLSITDQQLPMFI
RIMQLGISLYYGEIGNFKDGENEDLICHTKDV-LGNIS-GSEDEIGKDMQY----ISPES
YTQQDDDQQQGWVSWAWSFVPAIVGTDDEEGY---YVGTDDGTTINQQKLPTVKDPIASI
GFYCTKATITFKLTEMQAESSYYSPQKVKSKEIICWEQEGTTVEILMSGEPFFDCQIGFV
GCHALCLKSIMGIKDFEENMNRSDAEAYFLHCGENLSTKGMTYLTNSLFDYRSPENNGVR
AEFILDGTAHKEMYTEITGMQRFGAFYMDYLYTMESTRGKV--SGNQPDVTSVKTEDFGN
-IQEMSTKSLIVGPLSLRLDSSAVHRIMKMVVCALEHEYEPYSKSKPDFVDGAKTVLVSD
EVAALEEYIPTRITNFTIVKCSVIIPMAEFNLLGHLLPIIMGQKSSSCFLNTANLQPLRP
LPCIQMHVDKVVLEHSVPMYAEQLVQTVSSLNQPSDNLLHYCYAHCYLKIFGFQAGLSSL
DINGSYSSPASVIPPLSTAFYGKMLQLPKHWSKWSNVAVNECIFELPNLTIQATRAQTFL
MQTIWQSWAY-TGNVSSPVVNEALVNEVFQL-PGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDGGKEKRIPLIQGPSDTRDLHSSKWLNESRKPESIL
APDLLAFTVQIPQHKDYSYSS---------------------------GAVLLASVQGLT
INIDPVLYTWLVYQPQKRSNRPVQQ-------SGSVSLGTP-VTRKKEDEASIGSTPLPK
QPSNQASEYASSPVKTKTVTESRPLSIPMKAMLSSLETCSKSPEERMKECIGIVWNAVKR
LTLQLEVQSCCMFIPNDSLPSPSTIVSGDIPGTVRSWYHGQARMPGTLVLCLPQIKVMSA
GHKYMEPLQEIPFVVQRPILEE---GDAFPWTVNLNHFSVYTLLGQQMTLNLIEPMGCTS
TLAVTSQTLHVAGPESKHSFVVCLHVDLESLEVKCSNPQVQLLYELTDIMNKVWNKIQKK
GILHHS--QAYTESASGPAPPSSPIKSSVGTAPLDTSTCSPSADFGTTTEGESLQGGDDS
PFSDSITLEQTTSNIGISSGRVSLWMQWMLPKLTVKLFAPDPENKGT---EICVVGELED
LSASV--DVQDVYTKVKCKIESFNVDHYRN---------------------------SFG
EDSWSLGKCGGVFLSCTDKLNRRTLLVRPVSKQDPFS----NFSGFFPSA--TAKLLDGS
HQQHG-FLSLTYTKAVTKNVRHKLISRNER--RTLHKLSESFTDGSPHFLHEILLSAQAF
DVVLCFPFLNAIASIFQAKRPQSQKEKRKSPGQPLRTHILTSRNLPLIYINTGVIRIFFP
KMDERQQN--VEDSKTDKEDTLVLKIGSVSMAPQADNPLSRVVLRKDIYQRALNLGILRD
PGSEVEDRQYQVDLQSINIGTAQWDQLKPEKENGKG------------------------
--------------------------------------R---------------------
-------------------------------------------------TVPENERNSQN
PALEWNMASSIKRHQERRAILTPILTDFTVRITAAPAIIFTKVISPENLHTEEMLVCGHS
LEVNMTTSLDFFLSVAQVQLLQQLIQANMIGLEPCNKATEVSKHEQK-------------
---------------------K-------------------------MDTSDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSHHRIARPSR
QSSIVKNLNFIPFDIFITASRISFMTYSSTSLSKSKSAEEQRDGEKTTKSSLNLGETVDS
---DCKKTVGAGISSITADEILNSNNSQPSGKKTGLLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLHLVVSQPSLILSCHHRKQRMEISVFDAILKGVASDYKCADPGKT
LPETLDYCKM-WLQTVAGEADAKSGIPPPLITLQIKDFLNGPAEVNVDIAKPLKANISFV
KLDQIKQFLKKIRSKSDYETQ---EENVSTADSLSKKDGTLTSQCYKSRIPDSEDHSDGG
QKFSSQKNLWTSISCCQKISIHTTQMVISIETFPDSSKPC-------LLASL--------
---------SSLRGNLHVKANSKIKGR-INGSTIMLDINDFLIKTSLQEKSRTLLGPVCC
SVTVEAKWCKHSGNPGPELSIPKVYIDVRGGLMQVF-----WGQEHLNCLVLLHERLQSY
LLQEGKENRQGTTQ-IYPAQIPAERNQGSKTEHTSDDLRTGLFQYIQD---TEAQKLPSA
YEVVFYNETEDNPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------IPCSLEYWDELQKAFVAFREFSLSESKVCELSLPTINLMTDQKELVAS
DLWRIVLNSNQNSGDDQSS--------ESESGSQSACDQLVTPTALAACTRVDSCFTPWF
VPSLGVSIQFAHLELHLCHHLDQLGTA---------------------------------
----SPKFLHPFISDKNVPSELEYSIISFKKPHIYLRQWRDGSVFKEIQFSTKIHCKLLE
YRNVTMQDIVKPFGVFGQIAISGNLVERLLDGQVMVDPIFISFGQHAVHSLHKTLQAWQQ
NQ-CPEAE-ELVFSHFVICNDTQETLRFGQVDT-DENVLLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSIDNAGTFIRTIQYKGRTASLIIKVQPLNGVQKQ
IIICGRQIVCSYLSESIEIKVVQHYIGQDGQAVVKEHFDCLAPKQKLPSYVLENNELTEL
SVKAKGNEDWSRDVSLESKHTEYSTVIQVPSSNNSIIYVWCMVLTLEGNSQVEQRIIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSEMQMIPGKGQEKTLQNIEPDLTHHLTFQAREEDDP
SECAVPISTTLIKQITTKSNTGGTAN-EILADFYGCGNLPYSVWPYTKKDFVSG---EQL
TQWDSPMRVKLSVWKPCVKTLLIELLPWALLINHSKWDLWLFEGEKIVLQIPAGKTMIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNMTSPKWKDGDNEEVVTLDEEGFVEAEIKLGA
FLGHQKLCQFCISSNVQRGIQILQIEDKSIIVNNTPYQIYYRPQLSVVKSQL-TEEFSHV
PDSSTFSICSAMESGAAK--ASSILFWDFVHDANYSVSD--ALPLQKYMLLSLKH----D
TGPSWGPPAIIRQEFPRQSIAIPICGRDEQGFSTRAIALTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVSLLIKENFK--DTPKFDVYCKHVPAESSVHHELYHQVSSYPDCKMKDLVPSI
VLKVLSSEELTNEWSDCVDINNQGTQIVFLTGFGYVYVDVAHQCGSIVITLAPEGRPGH-
QTSLNRTQEQSLVFKTFISQLSVAVNDDITNP-----KML-SELLRFTIDHIYLHMVPVA
SYLRPLSHEFNGEATNS------------IQQFYTLQIYCGDLQLDNQLYSKSNFHFPVL
LCQ-----------GEKNE---SIQWT-KMHSPVGSSKDLEEYSENSFIKLCLTLSEE--
QNLLFHVNELSFEMRPARLYVEDTFVYYVKTLFETYLPDSK--SIYPSTK----ASASSQ
ILPEQVRQHANALVNPVKLRKLAIQPVSLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--IHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPENLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFAKPIGGAAELVSQTGYGILHGAGLSQHPKQRCSPSDQHAE-QAPNSHIKYVWKMLQ
SLGRPEAHMALDVVIVSGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPVTEIECLQDSE
QSNLLKVQLKQQRVPSDSEADGGRERLSEQQYNRLVDYISKTSCHFVPGTVSVQTA-APV
VAAEPIPTTVKTHQYLVDPVFAQVFISKFTMVKNKALRRGFN

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3074)

SCGSNSTNRSTTENTKSS
VKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEESACHNKDV-LGNVT-GAEDETRLDMQYPSQYKGQEL
YSQQEDEQPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPTSTTHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSIKGLTYLTNSLFDYRSPENNGTR
AEFILDAASHKETYTEIAGMQRFGAFYMDYLYTMENTNGKG--SANQQDFSSGRSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCSLEHEYEPYSRLKPDTKDESETVLNPE
EVASLEEYIPTRHTSVTLLKCTFTIFMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSGLTQPSDNLLHYCYAHCYLKIFGFQAGLTSL
DCKGSYCLPVPIIPSFSTALYGKLLKLPTCWAKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-TGNVSSLAVNEALMNEVFQS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDNGKEKLIPLLQGPSDTKDLHSSKWLNESRKPESLL
APDLIAFTVQVPQYMDYCHSS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQRRTSKHMQQ-----QPVIPVPLVVP-ISRRKEDEVSVGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPMKAMLNISEGCR-SPEERMKEFIGVVWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGMLVLCLPQIKIVSA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLFGKQVTLCLVEPMGCTS
TLAVTSQKLLTAGPDTRHSFVVCLHVDLESLEIKCSNPQVQLLYELTDIMNKVWCKIQRR
GNLSPS--SAHPESLAGPVP-SSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSVQALDDS
PFSDSVTLEQTTSNIGGSSGRISLWMQWVLPKITIKLFAPDPENKGT---ELCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTEEVQPS-I-EVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------E----S---G----T---G----G---V----L---T----E---
N----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLAPSSKATEISKQEQK-------------
---------------------K-------------------------MDAYDGSMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCTALPKSKSQEQK-DNEKTGKSSLNLPEVDS-
---DITKPSQACISMVTADDLLSSNVSFPSGKKIGVISLESLHASTRSSARQALGVTIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADIHLDISKPLKANVSFT
KLDQINNFLKKIQSAH----C---RETSALSDTMPNKDELPASRCYRGKLSKLKVHGDGT
QKIPFTENVWKTVSCFQKISVHTTQLVVSMETVPHPNKPC-------LLASL--------
---------STFSGSLNVKATQKVPGV-ILGSSFVLSVNDFLLKTSLKERSRVLIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGAFDVQASEA-VPQMPSPKEKNQMFKGEQSSDDLRTGLFQYIRD---AEPLKMPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------IPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSACDQLVTPTALAACTRVDSCFTPWF
VPSLCISFQFSHLEFHLCHHLDQLGTA---------------------------------
----PPQYLQPFVSDKNVPTELEYMIISFREPHIYLRQWNNSSVCQEIQFSAHADCKLLE
CRNVTMQSLVKPFSIFGQVAVSSSAAEKLIDCAIVIDSVFVNFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVF

PF06650 // ENSGT00410000025397_2_Domain_1 (3074, 3232)

SHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4167)

QQLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
CVRAKGDEDWSRDVCLESKAPEYSVVIQVPSSNSSIIYVWCTVLTLEPSSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQVIPGKGQEKPLQNIEPDLVHHLTFQAREEDDP
SHCAVPISTSLIKQIATKIHPGGTVN-QILDEFYGPEKSLQPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSAWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIILQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVSLDEEGFVDAEITLGA
FPGHQKLCQFCISSMVQQGIQVIQIEDKTTIINNTPYQIFYKPQLSVSTPQS-GKEYFHI
PDGATFSLHPGGEQPAVT--FSSLPCWDLRPDISQSALD--ASLLQKQILLAFAPAAAAN
SSQYWSLPAVVRQEFPRQSVAVPLGSCGENGFCTRAIALTYQEHFGVTYLTLSEDPSPRI
IFHNRCPVTILIKENIK--DIPKFEVYCRKIPPECSVHHELYHQMSSYPDCKTRDLLPSL
LLRVELLEEMTTEWSDAIDINNQGTQVVFLTGFGCVYVDTVHQGGTIFITVAPEGKAGPI
LTNTHRTPEKIMALRMVITQLSVAVLDDLTHH-----RVS-SELLRLTLDNVFLRLAPVA
G---HLPGE---EAAAAP-----------VH-LYCVEVCCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PSPCA-KMQSLLVSSHDLEEYRKKCFIKFCLTLAEGK-
SCSF-DINEFSFELKPARLYVEDTFVYYVKTLFETYLPSGG-P-ATHAPLLAG----GTQ
GLPLQVRQHARALVHPVRLRKLVIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4310)

VNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPGDLHAD-QAPNSHAKYVWKMLQ
SLGRPEVHMTLDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QSNLLIVQLKQPRVACDVEVDGTRERLSEQQYNRLVDYITKTSCHLAPSCSFVQTP-CPV
VAVEPLPSTVKTYHYMVDPPFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCYNKDM-LGNIA-GSEDETRVDIQYPAQYKVQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEVQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRALCLKGIMGVKDFEENMNRSETEACFFICGENLNTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENEAILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFTNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVPVVSSLTQPSDNLLHYCYVHCCLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSAVNEVLINEIFLS-IGKS-----TIFLIRIWK----------
------ICVRGN------------------------------------------------
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M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDHAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGEMEDSTCHNKDM-LGNIT-GAEDETKIDMQYPPQFKGQEL
YSQQDDEQPQGWVSWAWSFVPAIVSYDDSEED---YLGNDPTSITHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEILCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSEAEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDTAHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSTGKSEDVGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSKLKQDIKHDNETILNPE
EVASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLLPVIMGEKNSSTFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVRVVSSLTQPSDNLLHYCYVHCYLKVFGFQAGLTSL
DCSRSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIPITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVNTSAVNEALMNEVFQT-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHCTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHNS---------------------------GAVFLCSVQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QSVVAVPFVMP-SSRRKEDEVSVGSAPFTK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMLNISEGCR-SPEERMKEFIGIVWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVAGDIPGTVRSWYHGQTSMPGMLVFCLPQIKVISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYEITDTMNKVWNKIQKR
SNLSPS--SAYADTMAGPVP-TSPVRSSVGTAPPDTSTCSPSADIGTTTEGDSIQAGDDS
PFSDSITLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDPENKGT---EICMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTEKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EIQP-TVEVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWSQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLYQLIVANMTGLESSTKATEISKQEQK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALPKSTS-PEQKDNEKTGKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLSSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTSDFQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCSDPGKT
LPEVLDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINHFLKKIKSAHDLAHS---RETSALSETTLSKDELLVSKCYRGKLSKPKVHGEGV
QKISVQENMWRAISCFQKISVHTTQIVISMETVPHPSKPC-------LLASL--------
---------SNLNGSLTVKAVQKVPGI-ILGSSFLLSINDFLLKTSLKERSRVLIGPCCA
TANLEAKWCKHSGNLSPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LYEEGNFEVQVSEP-VPQMPSPMEKNQTFKSEQSSDDLRTGQFQYIQD---AESLKLPGI
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----PPQYLQPFISDKNVPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSVSGQIAVSSDAIENLLDCTMIVDSIFVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLIHHLTFQAREEYDP
SDCAVPISTSLTKQIATKLQPGGTVN-QILDEFYGPERSFQPIWPYNKKDCDRN---EQL
NQWDSPMRVKLSIWKPYVKTLLIELLPWALLINQSKWDLWLFEGEKIVLQIPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPRWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPHS-GKEYFHV
PDSATFSICPNGEEPAMK--SSSLPCWDLMPDISQSVLD--ASLLQKQILLGFFPAAGAN
SSQCWSLPAIVGQEFPRQSVAVPFGNFRENGFCTRAIALTYQEHLGVTYLTLSEDPSPRV
IFHNRCPVTMLIKENIK--DIPKFEVYCKKLPSECSIHHELYHQISSYPDCKTKDLLPSL
FLKVESLDEITTEWSDAVDINSQGTQVVFLTGFGYVYVDIVHQCGTVLITVAPEGKAGSI
LSNTNRALEKIVTFKLFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNVFLHMAPGA
VPLSGE-----E-PAAT------------LFELYRVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------EEKTE---PIQCS-KMQNLLVSGKDLEEYKENCFIKVCITLSEG--
TSFLFDINEFSFELKPARLYVEDTFVYYIKTLFDTYVPNSK-L-AHHSAHLSG----GKQ
VLPIQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYATGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVRHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPNCSSVQTPW-PV
MAVEPPPSTVKTYHYLADPHFAQVFISKFAMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 102)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDVLQ-DDH

ENSGT00410000025397_2_Linker_0_1 (102, 3075)

ESCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGEMEDSTCHTKDM-LGNIT-GVEDETRIDMQYPAQHKGQEF
YSQQDDEQPQGWVSWAWSFVPAIVSYDDSEED---YLGNDPTSITHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEILCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSEAEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTVENTSGKG--STNQQDFSTGKSEDLGT
-VQEKSTKSLVIGPLDFHLDSSAVHRILKMIVCALEHEYEPYSKLKPDIKHDNETILNPE
EVASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLLPVIMGEKNSSTFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVRVVSSLTQPSDNLLHYCYVHCYLKVFGFQAGLTSL
DCSRSYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVNTSAVNEALMNEVFQT-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHCTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHNS---------------------------GAVFLCSVQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QSVVAVPFVMP-ISRRKEDEVSVGSAPFAK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMLNISEGCR-SPEEKMKEFIGIVWNAVKS
LTLQLEVQSCCIFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGMLVFCLPQIKVVSA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEMKCSNPQVQLFCEITDTMNKVWNKIQKR
GNLSPS--SAYTDTMAGPVP-TSPVRSSVGTAPPDTSTCSPSADIGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLADGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTEKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EIQP-TVEVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWSQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASD--------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------INLDISKPLKANLSFT
KLDQINHFLKKIKSAHGLAHS---KETSALSETMLSKDELLVSKCYRGKLSKPKVHGDGV
QKISVQENMWRAVSCFQKISVHTTQIVISMETVPHPSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLSINDFILKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LYEEGNFEMQVSEP-VPQMPSPMEKNQTFKSEQSSDDLRTGQFQYIQD---AESLKLPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFQEFSLSESRVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCIAFQFAHLEFHLCHHLDQLGTA---------------------------------
----PLQYLQPFISDKNVPSELEYMIVSFREPHMYLRQWNNDSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSVSGQIAVSNDAIEKLLDCTVIVDSVFVNFGQHVVHSLNTALQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVQEHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLNETQIIPGKGQEKPLQNIEPDLIHHLTFQAREEYDP
SDCAVPISTSLIKQIATKLQPGGTVN-QILDEFYGPERVLQPIWPYNKKDCDRN---EQL
NQWDSPMQVKLSIWKPYVKTLLIELLPWALLINQSKWDLWLFEGEKIILQIPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPRWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GKEYFHV
PDSATFSICPSGEQPAVK--SSSLPCWDLMPDISQSVLD--ASLLQKQILLGFFPAAGAD
GSQCWSLPAIVAQEFPRQSVAVPFGNFRENGFCTRAIALTYQEHFGVTYLTLSEDPSPRV
IFHNRCPVTMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
FLKVESLDEITTEWSDAIDINSQGMQVVFLTGFGYVYVDIVHQCGMVLITMAPEGKAGSI
LSNTNRTLEKIVTFKLFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNVFLHMAPGA
GPLSGE-----E-PAAT------------LFELYRVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------EEKTE---PIQCS-KMQSLLVSSKDLEEYKENCFIKVCITLSEG--
KSCLFDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSK-L-ACHSAHLSG----DKQ
VLPMQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSMFERGPIFT
TARQL--VHALAMHYATGAL--FRAGWVVGSLEILGSPASLVRSVGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVRHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGDGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQAGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCAQDSK
QSHLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPNCSSIQTPC-PV
VAVEPPPSTAKTYHYLADPHFAQVFISKFAMVKNKALRKGFP

FFFFFFFP

PF12624 // ENSGT00410000025397_2_Domain_0 (9, 103)

ILMSYVNRYIKNLKPSDLQLSLWGGDVVLSFFFFFFFVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKLRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSQTEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSVSSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGV-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LSEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSIFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4165)

LIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
LPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSSLS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSMHLSG----GKQ
MLPMQVTQHARALVNPVKLRKLVI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVTCDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYYYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 113)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSHSTNRS

ENSGT00410000025397_2_Linker_0_1 (113, 3075)

TTENTKPS
VKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDPTCHDKDM-LGNIT-GSEDETRIDMQYTAQYKGQEL
YSQQEDEQPQGWVSWAWSFVPAIVSYDDSEED---FLGNDPTSAMHQQKAQTLRDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFNCQIGFV
GCRALCLKGIMGVKDFEENMNRSETEACFFICGENLNMKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEVAGMQRFGAFYMDYLYTVENIIGKG--SANQQDFSPGKSEDMGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSGLKQDIKDENETVLNPE
EVASLEEYIPTRHTSITLLKCTCTIVMAEFNLLDHLLPVIMGEKNSSNFLNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYAHCYLKIFGFQAGLTSL
DCRGFYCLPVPIIPSFSTALYGKLLKLPTCWTERSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWCH-IGNLNSLSVNEALMNEIFQT-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSSKWLNESRKPESLL
APDLTAFTVQVPQYMDYCHNS---------------------------GAVLLCSVQGVA
VNIDPVLYNWLVYQPQKRTSRHMQQ-----QPVIAVPLVTP-ISRKKEDEVSVGSAPLAK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMLNISEGCR-SPEERMKEFVGVVWNAVKS
LTLQLEVQSCCVFVPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGMLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GNAFPWTISLHHFSMYTLFGKQVTFCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLQIKCSNPQVQLLYELTDNVNKVWNKIQRR
GNLSPS--SAYPETMAGPVP-GSPVRSSVGTAPPDTSTCSPSADFGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSSGRISLWMQWVLPKITIKLFAPDPENKGT---ELCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SFG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSLHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTQKEKRKSPGQPMRSHTLTSRSLPLIYINTSVIRIFVP
KTEEMQPS-I-EVNQTVKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLHSINIGTAQWDQLKPEK-----------------------------
---------------E----S---G----T---G----G---V----L---T----E---
S----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTDLDFFLSVAQVQLLHQLIVANMIGLEPSSKAKEISKQEQK-------------
---------------------K-------------------------MDTFDGSMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCSAIPKSKSQVHK-DNEKTGKSSLNLPEVDS-
---DVAKPSQACISTVTAEDLLSSRVSFPSGKKIGVISLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQIKNLLKRIRNTH----S---KETSAPLDTMLNKDEFPTSKCFCGKLSKPKVHGDGA
QKIPFQENMWRTVSCFQKISVHTTQIVVSMETVPHPDKPC-------LLASL--------
---------SNLSGSLNVKTAQKVPGV-ILGSSFLLNINDFLLKTSLKERNRILIGPCCA
NANLEAKWCKHSGNPGPEQSIPKISIDLQGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEKGNFEVQVPEA-VPQMPSPIEMNQIFKSEQSSDDLRTGLFQYIRD---AEPLKMPGV
YEVVFYNETEDSSGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------IPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVSDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFTPWF
VPSLSISFQFAHLEFHLCHHLDQLGTA---------------------------------
----PPQYLKPFISDKNVPSELEYMIISFKAPHLYLRQWNNSPVCQEIRFSSQADCKLLE
CRNVTMQSMVKSFSIFGQIAISREAVEKLLDCIIIVDSIFVNFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3222)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLVIKVRQLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYISQDGQAVIREHFDCLTAKQKLPSYILENSELTEL
CVKAKGNEDWSRDVCLESKSPEYSIVIQVPSSNSSIFYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGREKPLQNIEPDLVHHLTFQAREEDDP
SHCAVPISTSLIKQIATKIHPGGTVN-QILDEFYGPEKSLQPMWPYNKKDSDRN---EQL
SQWDSPMRVKLSVWKPYVKTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVSLDEEGFVDAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTIIINNMPYQIFYKPQLSVSKPHS-GKEYFHI
PDSATFSICPGGEQAAVK--PSSLPCWDLMPDMSQSPLD--TSLLQKQILLAFSPAAGAG
SSQCWSLPAIVRQEFPRQSVAVPFGNRGENGFCTRAVALTYQEHLGVIYLTLSEDPSPRI
IFHNRCPVTILIKENIK--DIPEFEVYCRRIPSECSIHHELYHQISSYPDCKTKDLLPSL
FLRAESLEDVTAEWSDAVDINNQGTQVVFLTGFGYVYVDIILQCGTVFITVAPEGKVEPI
LTTSNRTLEKMVTLKLFITQLSLVVFDDLSHH-----KAS-SELLRLTLDHVFLQVAPVA
G---PLPGE---EAVAAP-----------LR-LHAVELYCGDLQLDNQLYSKSNFHFAVL
VCQ-----------GENAG---PVQRA-KVHSLLASGRDLEEYKKDCFIKLCLTLSEGR-
SCRLDDINELRFELKPARFYVEDTFVYYIRTLFETYLPSGD-L-AGCPAGPSG----GEQ
VLPTQVRQHARALVNPVKLRKLVIQPVSLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYASGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQRTTEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALEVVMVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPITEIDCAQDSK
QSNLFTVQLRQPRVACDVEVDGARERLSEQQYNRLVDYITKTSCHLAPSCSSMQTP-CPV
VAVEPLPSTVKTYHYMVDPHFAQVFISKFTMVKNKALRKGFP

-------------------------------------------------E

PF12624 // ENSGT00410000025397_2_Domain_0 (51, 103)

LKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSSSTNRSTAENTKSS
TKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDELWDRAFMDISATDLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKVIKSVRWE---QSDC-QPKFP
RSAIL--------------------ASHLGET-PEPGL-GAEDEARIDMQYPAQHKGQEL
YSQ-GCEEPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPASTMHPQKVPALKDPIVSV
GFYCTKATVTFKLTEMQPESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVRDFEEHTNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEMAGMQRFGAFYMDYLYTMERSPGKG--PASQQDFPSGKNEDLGI
-AQEKSTKSLVVGPLDLRLDSSAVHRILKMVVCALEHEYEPYSRLKPESKDEREAMPSLE
ELASLEEYIPTRHTSVTLLRCTCTVFMAEFNLLDRLLPVIMGGKNSSNFTNAANFQSLRP
LPCIQILVDKINLEHSVPMYAERLVHVASSLSQPSDSLLHHCYVHCYLKVFGFQAGLTSL
SHGGSYCSPVPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTVL
LQAIYQSWSH-IGNAASSTVNETLMSEAFQT-QGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVRCASGTVGSIKVCAKAPGDSGKEKLIPLLQGPSDTRDLHSTRWLNESRKPESLL
APDLVAFTVQAPQSMDDCHHS---------------------------GAVFLCSVQGLA
VSIDPVLYTWLTYQPQRRTSRHVQ------QPVVAVPLVPS-VSRRKDEELSAGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLHIHEGSR-HPEERMKEFIGILWNAVKS
LTLQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSTPGTLVLCLPQIKIISA
GHKCLEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPPGPDGRHSFVVCLHVDLESLEIKCSNPQVQLLYELADTMSKVWNRIQKR
GTLSSS--SVYPETMAGPVP-GSPVRSSVGTALPDTSTCSPSADVVTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGCSGRVSLWMQWVLPKLTVKLFAADVGNQGT---EVCMVSELED
LSASI--DVQDVYTKVKCKVESFNVDHYQS---------------------------RPG
-EGWQSGHFEGVFLQCKEKP----------------------------VT--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSVHKLSEGFVDGSPHFLHEILLSAQAF
DVVLCFPLLNAIASIFQTKLPRTQKEKRKSTGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTKETQST-V-EVNQAAKEDTMVLKVGSVAMAPQADNPLSRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSSSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------LTESERNSQN
PALEWNMASSMRRHQERRAMLTPILTDFSVRITGAPAIISTKMISPESLHVEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKATEVSKQEQK-------------
---------------------K-------------------------TDAFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVNIRIVQIEPRSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSLAVPKFNLPEEK-EDGKTGRNPLSLPEVDS-
---DVAKPAQACISMVTAEDLFSS--SFPSGKKPRVLSLESLHAATRSCARQALGVTVVR
QPGRRGTGDLELHPFLYLVVSQPSLILSCHHRKQRAEVSVFDAVLKGVAPDYKCTDPGKT
LPEALDYNTV-WLQTVPGETDCKSGIPASLLTLQIKDFLNGPADITLDVSKPLKANLSFT
RLDQINHFVKKIKKAHGFANS---KEPSAPAETVLSQDEPPTSKGHHGRPSNIKLEITTS
NPVLQQHTIY---------------------STP---R----------------------
-------------------PLLLETNL-SLGSSLLLSISDFLLKTSLKERSRTLIGPFSA
TVNLETKWCKHSGNPGPQQSIPKIAMDLRGGLLQVF-----WGQEHLNCLTLLHELFSGY
LEEEGKVDVPAPES-APQVPSPVDKTQ-----QSSDDLRTGVFQYIQD---AEPLKLPGT
YEVLFYNETEESPGMMLWRYPEPRVLVLVRITPVPFNTTEDPDISTADLGDALQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCDLQLPDISLVSDQKKLVSS
DLWRIVLNSSQSATDDQRQ--------LREAA--ITCPPAMATGQ---------------
--------------------------T---------------------------------
----AAKHL---------------------------------------------------
-------------------------------------------AINLIHTL-AFIFFFFQ
NK-YPEAE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4167)

TASLIIKARPLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYVGQDGQAVVREHFDCLTAKEKLPSYILENSELTEL
CVKAKGDEHWSRDVCLEPKASEYSTVIQVPASNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLRETQIIPGKGQENPLQNAEPDLVHHLTFQAREEHGP
SDCAVPISTALIKQIATKTQPGGTVS-EMLDEFYGPEKSQEPIWPYSKKDCDRS---EQL
SQWDSPMRVKLSLWKPHVKTLLVELLPWALLISRSRWDLWLFEGEKIVLQVPAGKVIIPP
NFQEAFQIGMYWAHTNTVHKSAAIKLVHDVTSPKWKDGGDGEVVTLGEEALVDAEIRLGA
FPGHQKLCQFCVSSMVQHGIQVIQIEDKTTIINNTPYQIFYKPQLSVASPCS-GKEHFRV
PDSATFSICPGGEHPALK--SSSLPCWDFLPDVGPSM-D--TAVLQKQMLLGFSPAPGAD
GSQCWSLPALIRRELPRQSVAVPCGTLREHGLCTRAIALTYQEHFGVTYLTLSEDPSPRV
IFHNRCPVAMLVKENMR--DVPKFEVYCKRIPPESSVHYELYHQIMGYPDCKTRDLLPSL
LLRTESTGEMAAEWSDAVDTNSQGTQVVFLTGFGYVYVDIAHQCGTVIITIAPEGKAGPI
LSGTHRALEKMVSFKMFLTRLSLAVSDDLTHH-----QTS-SELLRLTVDNIFLHVCPVP
G---VLPGE---EPPSAL-----------LQ-LLCVEVCLGDLQLDNQLYSKSSFHFPVL
VCQ-----------GERPE---PARYS-RVQSLLTSDKDLEEYKQNCFIRLCLTGSEG--
TDFLFDVSEFSFELKPARLYVEDTFVYYIKTLFDTYLPHSR-V-AGHPAQLSA----ARQ
LLPAQVRQHARALVNPVKLRKLVIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4287)

VSLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGSCGWSTLSC----RPFTQLPFT----------QPP
APDAVGLLCDAGLA--------------AKRMRD--------AALGFKQVA-----ACLC
CVKMPQNLEGFKPLIEKTWTGILHGAGLSQLPKQRYQPRDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQGHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDTK
QNNLLTVQLKQPRVACDVEVDGARERLSEQQFNRLVDYIAKTSCHLAPSCNSLQTA-CSV
VAVEPPPATVKTYHYLVDPHCAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQHAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGEIEDPTCYNKDM-LGNIT-GSEDETRVDIQYPAQYKVQEL
YAQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTIHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEVQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGIKDFEENMNRSETEACFFICGENLNTKGFTYLTNSLFDYRSPENNGTR
AEFILGSTHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENEAILNPE
DVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFTNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCCLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTAVYGKLLKLPTCWTKRSQIAITEGIFELPNLTLQATRAQTLL
LQAIYQSWSH-IGNVSSSAVNEALINEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLKESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------SVVLLCSVQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAVLNISEGCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNESLPSPSTIVCGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQLTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFCELTDTMNKVWNKIHRR
GNLNLS--SSSPETMAGPVP-TSPVRSSIGTAPPDTSTYSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSISIGTAQWDQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHSEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKASEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQQSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTGKSSLNIPEVDS-
---DVAKPNQACISTVTAEDLLSSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYRTV-WLQTVPGEIDSKSGIPSSLITLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINLFLKKIKNAHSSAHS---EETSALPNTMANKDDLPVSKYYRGKLSKPKVHGDGV
QKISVQENMWRAVSCFQKISVQTTQIVISMETVPHASKPC-------LLASL--------
---------SNLSGNLSVKAAQKVPGI-IFGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPVEKNQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKSFVAFREFSLSESKVCELQLPNINFVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFRLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRSMPSELEYMIVSFREPHMYLRQWNNDSVCQEFRFAAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTMIVDSVFVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3233)

HFVICNDTQETLRFGQVDT-DENVLLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKVQ

ENSGT00410000025397_2_Linker_1_2 (3233, 4165)

QLNGVQKQ
VCFFVF------MTQT-------------------------PLNYTVP------------
---TFLVEDWTPPTCLFSKYCKLNMAK------KSG------------------------
--------------------------------------------IYACFFFQFPREEYDP
SDCAVPISTSLIKQIATKVYPEGTVN-QILDEFYGPEKSLQPIWPYNKKDSERN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEGFVDAEIRLGA
FPGHQKFCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPQF-GKEHFHV
PDSATFSVCPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLEKQILLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPFGNCRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAVDINSQGTQVVFLTGFGYVYVDIVYQCGTVFITVAPEGKAGPI
VTNTNRALEKIVTFKMFITQLSLAVFDDLSHH-----KAS-AELLRLTLDNVFLRMAPEA
GPLPRE-----E-PVAP------------LFEFYCVEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KIQSLFISNKDLEEYKEKCFIKLCITLSEG--
RSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSG-L-AGHSTHLSR----DKQ
MLPVQVTQHARALVNPVKLRKLVI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPVSLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPITEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMLTP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDSTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSVSSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGAMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGV-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LSEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTYDPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGENIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPLS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMAAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYEPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMPIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

-------------------------------------------------E

PF12624 // ENSGT00410000025397_2_Domain_0 (51, 104)

LKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNHSTAENTKSS
IKPRRMQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKEGKIEDLTCHNKDM-LGNIT-GSEDETRIDMQYPAQHKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQVESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGDNLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVALLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALINEIFLS-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHNFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--STSPETMAGPVP-PSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEES
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNVDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFIP
KTE-EMQP-TVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VVTETERNSQN
PALEWNMASSIRRHQERRAILTPVLTDFSVRITGAPAVIFTKVVSPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDIFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKNNEKTNKSSLNLPEVDS-
---DFAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCIDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQINLFLKKIKNAHSLAHS---EETSAMSNTMVNKDDLPVSKYYRGKLSKPKIHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKATQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEEGNFEVQVSEP-VPQMSSPVEENQTFKSEQSSDDLRTGLFQYVQD---AESLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLLE
CRNVTMQNVVKPFSIFGQMAVSSDVAEKLLDCTVIVDSVFVNLGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3232)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKV

ENSGT00410000025397_2_Linker_1_2 (3232, 4166)

QQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPGGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVCNPYS-GKEYFRV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPDISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVKMLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVEPLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVHQCGTVFITVAPEGKAGPI
LTNTNRAPEKIVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDNIFLCVAPGA
GPLPGE-----E-PVTA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKEKCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
VLPMQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
IKPRRIQQAAPADPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDPPCLSKDT-LANLT-GTEEESRIDMQYPAPYKGQEL
YSQ-DYEEPQGWVSWAWSFVPAIVSYDDGEED---DLGTDPASIMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGILGVKDFEEHMNRSETEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKG--PTSQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDCRLDSSAVHRVLKMIVCALEHEYEPYSRLKPESKDEKETVLDPE
EVSSLEEYIPTRHTSVTLLKCTCTVFMAEFNLLDCLLPVIMGGKNSSNVTNATNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSSLNQPSDNLLHYCYVHCYLKVFGFQAGLTCL
DHSGSYCLPAPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVSSSTVNEALMNEVFPM-TGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTLGSIKICAKAPGDSGKEKLIPLLQGPSDTRDLHSSKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHHS---------------------------GAVFLCSVQGLA
VNIDPILYTWVIYQPQKRANRHAQQ-----QPVVAVPLVTS-VNRRKEDELSIGSAPLGK
QQSYQASEYASSPIKTKTVTESRPVSVPVKAVLRVHEECR-SPEDKMKEFIAILWNAVKS
LTLQLDVQSCCVFIPNDNLPSPSTIVSGDIPGTVRSWYHGQTSIPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPVGPDGRHSFVVCLHVDLESLEIKCSNPQVQLIYELADTMSKVWSKIQKR
GNLSPS--SVYPETVAGPIP-GSPVWSSVGTAPPDTSTCSPSADIGTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATVKLFAPDLEKKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKVESFSIDHYQS---------------------------RPG
-EGWQSGHFEGVFLQCKEKP----------------------------VT--TTKLLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFYKLSEGLMDGSPHFLHEILLSAQAF
DIVVCFPLLNAIASVFHTKLPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETQST-V-AVNQAAKEDTMVLKVGSIAMAPQADNPLGRSVLRKDIYQKALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSGSG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------PTESERNSQN
PALEWNMASSIQRHQERRAILTPILTDFSVRITGAPAIIFTKIISQENLHMEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSTKATEISKQEQK-------------
---------------------K-------------------------VDTFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQYSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKFKLPEQK-EDGKTGRTFLNLAEVDS-
---DVAKPNQACVSMVTAEDPLSSSTSFSSGKKVRVLSLESLHASTRSSARQALGVTVVR
QPGRRGTGDLELDLFLHLIVSQPSLLLSCHHRKQRVEVSIFDAMLKGVPSDYTCTDPGKT
LPEASDYNIV-WLQTVPGETDSKSGIPPSLVTLHIKDFLNGPADIYLDVSKPLKANLSFT
KLDQINHFLKKIKKAHSSAHS---KETSTPSDSILNMDEPPVPKCYRGKLSKTKVHCDEA
QKTSFQENIWRAISCFQKVSVHTTQIVVSMETVPHPHKPC-------VLASL--------
---------SNLNGSLTVKAAQKVPGA-SLGSSFLLSIHDVLLKTSLKERSRILIGPFSA
TVNLEAKWCKHSGNPGPQQSIPKISMDLRGGLLQVF-----WGQEHLNCLALLHELFNGY
LQ-EGKSEMPVPES-APQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQD---AESLKLPGV
YEVLFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCGLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLVHDQKKLVSS
DLWRIVLNNNQNTTDDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFRLCHHLDQLGTA---------------------------------
----SPQYLQPFISDKNVPSELEYMIISFREPNLHLRQWNSGPVCQEIKFSSQMDCKLLE
CRNVTMQTVVKPFGICGQMALSSDGVQKLLDSTVIVDSVLVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3225)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFTVDHAGTFIRTIQYKGRT

ENSGT00410000025397_2_Linker_1_2 (3225, 4165)

ASLIIKVRALSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLEPKASEYSTVIQVPTSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGRGQENPLQNVEPDLVHHLTFQAREEYDP
SDCAVPISTALIKQIATKIQPGGTVN-EMLDEFYGPEKSQEPTWPYSNKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWENTNTVHKTLAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQVIQIEDKTTVINNTPYQIVYKPHLAISNSYS-GKEHCHV
PDSATFSICPGGEHPAVR--SSSLPCWDVTPAVGSSELD--TATLQKQILLGFSPVPGAD
SAQCWSLPAIIGGEFPRQSVAVPFGTGRENGFCTRAIALTYQEHLGVTYITLSEDPSPRV
VFHNRCPVPMLMKENIR--DIPKFDVYCKKIPPESSVHHELYHQIISYPDCKTKDLLPSL
FLRIDSMEEMTAEWSDPVDINSQGTQVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPI
FTSTSRALERMVTFRMFITQLSLAVSDDLTHQ------AP-SELLRLTLDNVFLHVSPVP
A---LLPGE---EPPSSF-----------FQ-LYGVEVYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GERTD---PAQYS-RVQSLLVSSKALEEYKENCFIKLCLTVSEG--
KDILLDVSEFTFELKPARLYVEDTFVYYIKTLFDTYLPPSR-M-SGHHAQLFT----GQQ
VLPVQVTQHAKALVNAVKLRKLLI

PF16909 // ENSGT00410000025397_2_Domain_2 (4165, 4310)

QPVNLLISIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRCQPTHLYAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEISCAQDTK
QNNLLTVQLKQPRVASDVEIDGARERLSEQQFKRLVDYIAKTSCHLAPSCSSMQ-T-CSV
VAVEPPPATVKTYHYLVDPHFAQVFISKFTMVKNKALRKGFS

MLESYVTPILLSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLMDGIQ-DDHDSCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDEFWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLAIALYYGEIGNFKDGETEDSTCHNKDM-LGNIT-GAEGETRIDMQYPAQYKGQEL
YSQQDDEQPQGWVSWAWSFVPAIVSYDDSEDD---YLGNDPTSIMHHQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEILCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSEAEACFFICGENLSTKGSTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMENTSVKG--SINQQDFSAGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMVACALEHEYEPYSRLKSDIKHESETLLNPE
EVASMEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLLPVIMGEKNSSTFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVRVVSSLTQPSDNLLHYCYVHCYLKIFGLQAGLTSL
DCSGCYCLPVPIIPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTVQATRAQTLL
LQAIYKSWSL-IGNVSSLAVNEALMNEVFQA-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGESGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHSS---------------------------GAVFLCSVQGLA
VNIDPVLYTWLIYQPQKRASRHIQQ-----QSVVAVPLVMP-ISRRKEDEVSVGSAPLAK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMLNISEDCR-SPEERMKEFIGIVWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQASMPGTLVLCVPQIKVISA
GHRYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDMRHSFVVCLHVDLESLEIKCSNPQVQLFRELTDTMNKVWNKIQKR
GNLNSS--SVYPETIAGPVP-TSPVRSSVGTAPPDTSTCSPSADIGTTTEGDSIQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKVTIKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAITSIFQAKLPRTQKEKRNSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EIRP-AVEVDQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESGTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSAKATEISKQEQK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETLSRHSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSVALPKSKS-QEQKDNEKTGKSSLNLPEVDS-
---DVAKSNQACISTLTAEDLLSSSISFPSGKKIGVLSLESLHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLVSCHHRKQRVEISIFDAVLKGVASDYKCSDPGKT
LPEPLDYCSV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQLNHFLKKIKSAHDLAHS---KETSAPSETTLNKDELLVSKCYRGKLSKPKIHGDGV
QKISVQENMWRAVSCFQKIAVHTTQIVISMETVPHPSKPC-------LLASL--------
---------SNLNGSLSVKAAQKIPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPSCA
TANLEAKWCKHSGSPGPEQSVPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LFEEGNFELQSSGP-VPQIPSPMERNQAFKSEQSSDDLRTGQFQYIQD---ANSLKLPSV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFTHLEFHLCHHLDQLGTA---------------------------------
----PPQYLQPFISDKNVPSELEYMIVSFREPHMYLRQWNGGSVCQEIQFSTQADCRLLE
CRNVTMQSVVKPFNVSGQIAVSRDAVEKLLDCTVIIDSIFVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKVQQLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLNETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQITTKLHPGGTVN-QILDDFYGPERSLQPTWPYSKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQIPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHDLTSPRWKDGGNGEVVTLDEEGFIDAEIRLGA
FPGHQKLCQFCISSMIQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSNPHS-GNEYFRV
PDSATFSICPGGEQPAVK--SSSLPCWDLMPDISQLVLD--ASLLQKQILLGFSPATGAD
IAECWSLPAIVRQEFPRQSVAVPLGNFRENGFCTRAIVLTYQEYFGVTYLTLSEDPNPRL
IFHNKCPVTMLIKENTK--DIPKFDVYCKKVPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDAITTEWSDAIDINSQGTQVVFLTGFGYVYVDIIHQGGTIFISVAPEGKAGSI
LSNHNRTLGKIVTFKMFITQLSLAVFDDLTHH-----KAS-AELLRLTLDHVFLHMAPGA
GPLPGE-----E-PAAA------------LFKLYCVEVYCGDLQLDNQLHSKSNFHFAVL
VCQ-----------EGKIE---SVQCS-KMQSLLLSNRDLEEYKENCFIKVCITLSEG--
KSFFYDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSK-L-ASPSTHLSG----GTQ
VLPVQVRQHARALVNPVKLRKLVIHPVNLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCAQDSK
QHNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPNCSSMQTPS-PV
VVVDPPPSTVKTYHYLVDPRFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 104)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHES

ENSGT00410000025397_2_Linker_0_1 (104, 3075)

CGSNSTNRSTAENTKSS
VKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDSETEDSTCHNKDM-LGNIT-GTEDETRIDMQFSAQYKGQEL
YSQQDDEQPQGWVSWAWSFVPAIVSYNDGEED---YFANDPASTMHQQKAQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAVCLKGIMGIKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDAAYHKEIYTEMAGMQRFGAFYMDYLYTMENTSGKG--SANQQDLSSGKNEDLGT
-MQEKSTKSLVIGPLDFRLDSSAVHRILKMVVCALEHEYEPYSRLKPEIKDENETILNHE
ELASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDHLLPIIMGEKTSSNFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAVQLVHVVSSLSQPSDNLLHYCYIHCYLKIFGFQAGLTSL
DCNGSYCLPVPIIPTFSTALYGKLLKLPTCWTKRSQIVLTEGIFELPNLTIQATRAQTLL
LHAIYQSWSH-IENVSSSGVNEALMNEVFQT-VGVK-----SKNPLPALEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPGDIGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHNS---------------------------GAVLLCSVQGFA
INIDPILYTWLIYQPQKRTSRHMQ------QPVVSVPVVTP-ISKRKEDELSVGSAPLAK
QQSYQASEYASSPVKTKTLTESRPLSVPVKAMLNISEGCR-SPEERMKEFIGIVWNAVKS
LTIQLDVQSCCVFIPNNSLPSPSTIVSGDIPGTVRSWYHGQSSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLIAAGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELADTINRVWNKIKKK
GNLSTS--SAYSETVAGPVP-SSPVRSSVGTVPPDTSTCSPSADIGTTTEGDSIQAGDES
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDLENKGT---EVCMISELED
LSASV--DVQDVYTKVKCKIESFNIDHYRI---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPSA--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQTKLPR-QKEKRKSPGQPTRTHTLTSRNLPLIYINTSVIRIFVP
KTE-EMQP-AVEVNQAAKEDTMVLKIGSVTMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKENTTG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTENERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKATEISKQELK-------------
---------------------T-------------------------MDTFDGGAA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQQSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSTALPKLKS-QVQKEDEKTGKSSLNLPEVDS-
---YGTKPSQSCISIMTAENLLTSDTSLTSGRKIGILSLENLHASTRSSARQALGITIIR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKM
LPEGLDYSTV-WLQTVPGETDSKSGIPPSLITLQIKDFLNGPADICLDISKPLKMNLSFT
KLDQINNFLKKIKNAHSFAHH---KENSALSDTKLNKDEPTVS-SFHGKLSEPKVHGGGV
QKISFQENMWRAISYFQKISVHTTQIVVSMEPVPHPNKPC-------LLASL--------
---------SNLSGNLSVKTAQKVPGI-ILGSSFLLGIDDFLLKTSLKERSRILVGPFCS
TANLEAKWCKHSGNPTPEQSLPKVSIDLRGGLLQVF-----WGQEHLNCLVLLHDLLSGY
LNEEGIFEAQVSES-VSQMS-CMEENQAFKSEQSSDDLRTGLFQYIQD---AEPLKLPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDEILKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLITPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFHLCHHLDQLGTA---------------------------------
----SPQYLQPFISDRNVPSELEYMIISFREPHVYLRQWNNGSVCQEIRFSAHADCKLLE
CRNVTMQSVVKPFSISGQIAVSSSVGGKLLECTMRVDSVSANFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3233)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLVIKVQ

ENSGT00410000025397_2_Linker_1_2 (3233, 4167)

QLSGVQKQ
IIICGRQIICSYLSESIELKVVQHYIGQDGHAVVREHFDCLIPKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKAAEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQERPLENIEPDLVHHLTFQAREEYDP
SDCAVPISTALIRQIATKINPGGTVN-QILDDFYGPEKSLEPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSNWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGSNGEVVTLDEEAFVDVEIRLGA
F-GHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYHIFYKPQLSVSNPHS-GKEDFHV
LDSATFSICPGGEQSAVK--YSSIPCWDLMPDIGPSVLD--SSLLQKQILLGFSPAAGAD
SSQCWSLPATVRQEFPRQSVAVPFGNFRENGFCTRALALTYQEHFGVTYLTLSEDPSPRV
IVHNRCPVTVLIKENIK--EIPKFEVYCRKIPSESSVHHELYHQTSSYPDCKTKDLLPSL
FLRVDLLDAVSTEWSDAIDINNQGTQVVFLIGFGYVYVDIVHQCGTIFITVAPEGKAGPI
LSHANRSLEKMVTFKIFIAQLSLAVSDDLTHH-----RAS-SELLRLTLDNVFLHIAPVA
GAFPGE-----E-PTLT------------LFRLYTMEIYCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTD---PAQCP-RVSHLLIPSTDLEKYKENCFIKLCATLTEG--
KSFLLNVSELSFELKPARLYVEDTFVYYIKTVFDTYLPHCK-A-AGHPTQLCE----GAQ
LLPVQVRQHARALVNPVKLRRLVIQP

PF16909 // ENSGT00410000025397_2_Domain_2 (4167, 4310)

VNLLVSIHASLKLYIASDHTPLSFSIFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGTGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDQHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEYEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCAQDSD
QKHLLTVQLKQPRVACDVEVDGVRERLSEQQYHRLVDYIAKTSCHLVPSCSFMQTP-CPV
VAVEPPSSTVKAYHYLVDPHFAQVFVSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNHSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
HSQQDEEQPQGWVSWAWSFVPAIVSSDDGEED---CVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLNFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDQLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPKLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSVVNEALINEVFQS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKEFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADVGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENL--QEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKKDKSSLNLPEVDS-
---DVAKPNQACISTVTAEDLLRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLVSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYLGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TASLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEAGNFEVQVSEP-VPQMSSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKTLVSS
DLWRIVLNSSQNGADDQSS--------TSESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHIYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDIVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3227)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTAS

ENSGT00410000025397_2_Linker_1_2 (3227, 4166)

LIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPMWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPHS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKQIMLGFSPTPRAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFQENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
VPLPGE-----E-PAAA------------FFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLRITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QSNLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 101)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DE

ENSGT00410000025397_2_Linker_0_1 (101, 3075)

HESCGSNSTNRSPAENIKSS
VKPRRIQQTAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVDELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSIIKIHTLVESLKLSLTDQQLPMFI
RLMQLGIALYYGEISDFKDGETEDPACHSKDA-LGSLA-GTEDETRIDMQYPAQYKGQEF
YSQ-DCEEPQGWVSWAWSFVPAIVSYDVGEED---YLGSDPASTMHQQKVQTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAICLKGIMGVRDFEEHMNRSEAEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTVEHSRGKG--PVNQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDLRLDSSAVHRILKMTVCALEHEYEPYSRLKPESKDEKETVLNPE
EVASLEEYIPTRHTSVTLLKCTCTIFMAEFNLLDRLLPVIMGGKNSSNFMNATNFQALRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSGLPQPSDSLLHYCYVHCYLKVFGFQAGLTSL
THSGSYCLPVPIIPSFSTALYGKFLKLPAFWTKRSQTVVTEGIFELPNLTIQATRAQTLL
LQTIYQSWAH-IGNSSSSTVNEALMNEVFQT-TGVK-----AKNPLPTLEGSIQNAELKY
CSTSLVRCASGTVGSIKICAKAPGDNGKEKLIPLLQGPSDTRDLHSTKWLNESRKPESLL
APDLIAFTTQVPQHMDDCHLS---------------------------GAVFLCSVQGLA
VNIDPVLYTWLLYQPQKRTSRHMQQ-----QPVVAVPLVPA-VSRRKEEELSAGSAPLAK
QQSYQASEYASSPIKTKTVTESRALSVPMKTMLHIHEGRR-SPEERMKEFIGILWNAVKS
LTLQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSTPGTLVLCLPQIKIISA
GHKCMEPLQEIPFVIPRPILEE---GDAFPWTINLHHFSIYTLLGKQVTRSLVDPMGCTS
TLAVTSQKLLPPGPDGRHSFVVCLHVDLEPLEIKCSNPQVQLFYELADTISQVWTRIQKR
GNLSSS--SVCPETMAGPVP-GSPVRSSVGTAPPDTSTCSPSADIVTTTEGDSVQAGDES
PFSDSVTLEQTTSTIGGSSGRVSLWMQWMLPKVTIKLFAPDLENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYQS---------------------------SHG
EECWSLGQCGGVFLSCTDKLNRRTSLVRPVSKQDPFR----SCSAFFTST--TGKPLDGA
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLPDGSPHFLHEILVSAQAF
DIVLCFPVLNAVASIFQTKPPRTQKEKRKSSGQPLRTHTLTSRSLPLIYINTSVIRIFVP
QTAKTQSV-V-EVNQAAKEDTMVVKVGSVSMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKGSGPG------------------------
--------------------------------------G---P-----------------
--------------------------------------------------LPESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVTQVQLLHQLIVTNMTGLEPSNKATEISKQEQK-------------
---------------------K-------------------------MDTFDGGVA----
------------------ETCSRHSGAQDSGIGSDSVKIQIVQIEQCSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSSVPLPKSAVPEQK-EDGTTGKNSLNLPEVDA-
---DVAKPNQACISMVTAEDLLSGSNFLPSGKKIRVLSLESLHASTRSSARQALGVTVVR
QPGRRGTGDIELHPFLYLIVSQPSLLLSCHHRKQRVEMSIFDAVLKGVAPDYRCADPGKT
LPEALDYNTV-WLQTVPGETDSKSGIPPSLVTLQIKDFLNGPADINLDVSKPLKANLSFT
KLDQINHFLKKIKKVHSFEHS---KETSAPSDTILNKDKPPVSRCYRGKSSQPRVHCDGV
Q-TSFQENMWRATSCFQKISVRTTQIVVSMETVPHPHTPC-------VLASL--------
---------SSLNGSLGVSAAQRVPGE-SLGSSFLLSISDFLLKTSLRDRSRILMGPFSA
TVNLEAKWCKHSGNPGPQQAVPKIAVDLRGGLLQVF-----WGQEHLNCLSLLHELFSGY
LQEEGSFEVPVPES-APQMPSPVDKTQALKSEPSSDDLRTGSFQYLQD---AEPLKLPGA
YEVLFCSETDESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDLSTADLGDVLQ------
------------VPCSLEYWDELQKVFVSFQEFSLSESKVCELQLPDISLVSDQKKLVSS
DLWRIVLNNNQNAADDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLCVSFQFAHLEFRLCHHLDQLGTA---------------------------------
----SPRHLQPFIPDKNVPSELEYMVISFKEPTLYLRQWSSDSVCQEIRFSSQVDCRLLE
CRNVTMQTVVHPFGISGQIALSDDGVQRVLDGTVTMDSVLVNFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHRSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4166)

TASLIIKVHPLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHLDCLAAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLEPKASEYSTVIQVCEVELGM-----------------VAHIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQMIPGRGQENPLQNVEPDLAHHLTFQAREDYDP
SDCAVPISTALIKQITTKIEPGGTVN-QMLDEFYGPGQSHEPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHDVTSPKWKDGGNGEVVTLDEDAFVDAEIRLGA
FPGPQKLCQFCVSSMVQHGIQIIQIEDKTTVINNTPYQMLYKPQLSVSNPYS-GKEHFHV
PDTATFSISPGGEHSEMK--SSSLPCWDFMPDMGPSL-D--TAVLQKQILLGFSPAPGAD
SSQCWSLPAVVRREFPRQSVAVPCGTLRENGFCTRAIALTYQEHSGVTYLTLSEDPSPRV
IFHNRCPVTMLVKENIR--DIPKFEVYCKKIPSESSIHHELYHQIISYPDCKTKDTLPSL
LLRLESTGDMTAEWSDAVDVNSQGTQVVFLTGFGYVYVDIAHQCSTVCITIAPEGKAGPM
LTSANRALEKVVTFKTFITRLSLAVTDDLTHH-----KAS-SELLRLTLDNIFLHVCPVP
G---VLPGE---EPPSTL-----------LQ-LFSVEVYFGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---PAQDL-RVQSLLVSSKALEEYKENCFIKLHLTVSEG--
TDFLFDVSEFSVELKPARLYVEDTFVYYIRTLFDTYLPHSR-V-AGDQAQLSA----GEQ
VLPMQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLRLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGRKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPRDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDTK
QKNLLTVQLKQPRVACDVEMDGARERLSEQQFNRLVDYIAKTSCHLAPSCSSMQTA-CSV
VAVELPPATVRTYHYLADPHSAQVFVSRFTMVKNRALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSTKGFTYLTNSLFDYRSPENNSTR
AEFILDSTHHKETYTEMAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGNVSSSAVIEALINEVFLS-IGVK-----SKNLLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDNGKEKLIPLLQGPSDTKDLHGTKWLNESRKPESLL
APDLMAFTIQVPQYIDYCHNS---------------------------GAVLLCSIQGLA
VNIDPILYTWLIYQPQKRTSRHMQQ-----QPVVAIPLVMP-VCRRKEDEVSIGSAPLAK
QQSYQASEYASSPIKTKTVTESRPLSVPVKAMLNISESCR-SPEERMKQFIGIVWNAVKH
LTLQLEVQSCCVFIPNDSLPSPSTIISGDIPGTVRSWYHGQTNMPGTLVLCLPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDTMNKVWNKIQKR
GNLNLS--TTSPETMAGPVP-TSPVRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEDS
PFSDSVTLEQTTSNIGGTSGRVSLWMQWVLPKVTVKLFAPDPENKGT---EVCMVCELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------RPG
E-GWQSGHFEGVFLQCKEKS----------------------------VT--TTKLLDGT
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQAKLPKTQKEKTKSPGQPMRTHTLTSRNLPLIYINTSVIRIFIP
KTE-EMQP-TVEVNQAAKEDTLVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESVSG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQK-------------
---------------------K-------------------------VDTFDGGTA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSCMALSKSKS-QEQKDNEKTDKSSLSLPEVDS-
---DVAKPNQACISTVTAEDILRSSISFPSGKKIGVLSLESIHASTRSSARQALGITIVR
QPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSFITLQIKDFLNGPADVNLDISKPLKANLSFT
KLDQIHLFLKKIKNAHSSAHN---EETSAMSNTMVNKDDLPVSKYYHGKLSKPKVHGDGV
QKISAQENMWRAVSCFQKISVQTTQIVISMETVPHTSKPC-------LLASL--------
---------SNLNGSLSVKAAQKVPGI-ILGSSFLLTINDFLLKTSLKERSRILIGPCCA
TANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LNEAGNVEVQVSEP-VSQISSPVEKNQTFKSEQTSDDLRTGLFQYVQD---AEYLKLPGV
YEVLFYNETEDCPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDPLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----APQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFSAQADCKLLE
CRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDSVFVNVGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGRTASLIIKVQRLNGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENNELTEL
CVKAKGDEDWSRDVRLESKAPEYSIVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIMKSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEYDP
SDCAVPISTSLIKQIATKVHPRGTVN-QILDEFYGPEKSLQPIWPYNKKDSDRN---EQL
SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDTEVRLGA
FPGHQKLCQFCISSTVQQGIQIIQIEDKTTIINNTPYQIFYKPQLSVSSPHS-GKEYFHV
PDSATFSICPGGEQPAMK--SSSLPCWDLMPAISQSVLD--ASLLQKQIMLGFSPAPGAD
SSQCWSLPAIVRPEFPRQSVAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRV
IIHNRCPVTVLIKENIK--DIPKFEVYCKKIPSECSIHHELYHQISSYPDCKTKDLLPSL
LLRVELLDEVTTEWSDAIDINSQGTQVVFLTGFGYVYVDTVHQCGTVFITVAPEGKAGPI
LTNSNRAQEKIVTFKMFITQLSLAVFDDLTHH-----KAS-PELLRLTLDNVFLCMAPGA
GPLPGE-----E-PAAA------------LFELYCVEICCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKAE---PIQCS-KMQSLLISNKELEEYKENCFIKLCITLNEG--
KSILCDINEFSFELKPARLYVEDTFVYYIKTLFDTYLPNSR-L-AGHSTHLSG----GKQ
MLPVQVTQHARALVNPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEIIGSPASLVRSIGNGVADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNSLLTVQLKQPRVACDVEVDGVRERLSEQQYNRLVDYITKTSCHLAPSCSSMQIP-CPV
VAAEPPPSTVKTYHYLVDPHFAQVFLSKFTMVKNKALRKGFP

MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKTS
AKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDSTCHNKDM-LGNVT-GAEDETRIDTQYSAQYKGQEL
YSQQEDDQPQGWVSWAWSFVPAIVNYDDAEED---YLGNDPTSTTHQQKTQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRATCLKGIMGVKDFEENMNRSETEACFFVCGENLSIKGLTYLTNSLFDYRSPENNGTR
AEFILDAATHKETYTEIAGMQRFGAFYMDYLYTMENTTGKG--SANQQDFSSGRSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMVVCALEHEYEPYSRLKPDTKDESETMLNPE
EVACLEEYIPTRHTSVTLLKCTFTIFMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSVQILVDKINLEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYAHCYLKIFGFQAGLTSL
DCRGSYCLPVPIVPSFSTALYGKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-SGNVSSLAVNEALMNEVFQT-VGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTVGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSSKWLNESRKPESLL
APDLIAFTVQVPQCMDYCHSS---------------------------GAVLLCNVQGLA
INIDPILYTWLIYQPQKRSSKHMQQ-----QPVIAVPLVMP-ISRRKEDEVSVGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAVLTITEGCR-SPEERMKEFIGVVWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIVSA
GHKYMDPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLFGKQVTLCLVEPMGCTS
TLAVTSPKLLATGPDMRHSFVVCLHVDLESLEIKCSNPQVQLLYELTGIMNKVWNKIQKR
GNLSSS--SAYPESMVGPFP-SSPVRSSIGTAPLDNSTCSPSADIGTTTEGDSVQAVDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITVKLFAPDPDNKGI---ELCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------NLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLSRTQKEKRKSPGQPMRTHTLTSRNLPLIYINTSVIRIFVP
KTEEMQPS-I-EVNRTAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------E----N---G----T---G----G---V----L---T----E---
T----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKATEIAKQEQK-------------
---------------------K-------------------------MDTYDGSVA----
------------------DSSSRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSCTALPKSKSQEQK-DNEKTGKSSLNLPEVDS-
---DVAKPSQACISMVTAEDLLSSNISFPSGKKIGVISLESLHASTRSSARQALGITIVR
QPGRRGTGDLRLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPEALDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINHFLKKIKNVH----S---KVSSAPSDTVLNKDAFPASKCYRGKLSKLKVHGDGA
QKIPFQENIWRTISCFQKISVHTTQIVVSMETVPHPNKPC-------LLASL--------
---------STLNGSLNVKAAQKVPGV-ILGSSFLLSVNDFLLKTCLKERSRILIGPCCA
TANLEAKWCKHSGDPGPEQSIPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEEGNFEAEVSEA-VPQMPSPLEKNQIFKSEQSSDDLRTGLFQYIRD---AEPLKMPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------IPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDINLVNDQKKLVSS
DLWRIVLNSSQNGADDQSS--------ASESGSQSTCDQLVTPTALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----PPKYLQPFISDKNVPSELEYMVISFKEPHMYLRQWNNSSVCQEIQFSAQADCKLLE
CRNVTMQSLVKPFSIFGQTAISSNAVEKLIDCSIIIDSIFVNFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFSHFVICNDTQETLRFGQVDT-DENILLASLCSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTASLIIKAQQVSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKAPEYSVVIQVPSSNSSIIYVWCTVLTLEPSSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEDDP
SHCAVPISTSLIKQIATKIHPEGTVT-QILDEFYGPEKFLQPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSAWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLAHNLTSPKWKDGGNGEVVSLDEEGFVHAEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYQIFYKPQLTATKPHS-GKEYFRV
PDSATFSICPGGEQPAVR--SSSLPCWDLMPDLGQSALD--ASLLQKQVLLAFSPTAVAD
SSQCWSLPALVRQEFPRQSVAVPLGNYRENGFCTRAIALTYQEHLGVTYLTLSEDPSPRI
IFHNRCPVTILIKENTK--DIPKFEIYCRKIPPECSIHHELYHQISSYPDCKTRDLLPSL
LLRVELLEEMTAEWSDPIDINNQGTQVVFLTSFGYVYVDTVHHCGTVFINVAPEGKAGPV
VTNTNRTLEKIVTFKMFVTQLSLAVFDDLTHH-----RAS-SELLRLTLDHVFLQMAPVA
G---HLPGE---EMATAP-----------FH-IYSVEVCCGDLQLDNQLYNKSNFHFAVL
VCQ-----------GEKTE---SPQCS-KMQSLLVSSEDLEEYKKNCFIKLCLTLTEGK-
DVLF-DVNEFSFELKPARLYVEDTFVYYIKTLFETYLPSSS-P-GTQPTALAG----GRQ
VLPVQVRQHARALVHPVKLRKLVIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEAQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALEVVLVRGSGQEHEGCLLLTSDVLFVVSVSEDTQQQAFPVTEIDCAQDHE
QSGLLVVQLKQPRVACDTEVDGVRERLSEQQYNRLVDYITKTSCHLGPGCSSVQTS-CPV
VAVEPLPSTVKTYHYMVDPHFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHE

ENSGT00410000025397_2_Linker_0_1 (103, 3075)

SCGSNSTNRSTTENTKSS
LKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVSELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVDSLKLSITDQQLPMFI
RIMQLGIALYFGEIGSFKDGETEDPSCYNKDM-LGNIA-GAEDETRIDMQFPAQYKGQEL
YSQQDDEQSQGWVSWAWSLVPAIVSYDDGEED---YLGNDPASTMLQQKAPSLKDPIVSV
GFYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQLGFV
GCRALCLKGIMGVKDFEENMNRSEAEASFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDSAHHKETYTEIAGMQRFGAFYMDYLYTTENTSGKGISSANQQDFSSGKNEDLGT
-VQENSTKSLVVGPLDFRLDSSAVHRILKMIVCALEHEYEPYTRLKPEIKEENERILNPE
ELVSLEEYIPTRHTSITLLKCTCTIFMAEFNLLDYLLPVIMGEKNSSNFMNTTNFQTLRP
LPSIQILMDKINLEYSVPMYAEHLVHMVSSLSQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCNGSYCLPVPIIPSFSTAVYGKLLKLPTCWTKRSQIVITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNISSSGVNEALMNEVFQT-VGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNESRKPESLL
APDLIAFTIQVPQYMDYCHSS---------------------------GAVLLCSVQGFA
INIDPVLYTWLIYQPQKRTSRHMQ------QPMIPVPLVTP-ISKRKEDELSVGSAPLAK
QQSYQASEYASSPVKTKTLTESRPLSVPVKAMLNISEGSR-SPEEKMKEFIGVVWNAVKS
LTVQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGTLVLCLPQIKIISA
GHKCMEPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQMTLCLVEPMGCTS
TLAVTSQKLIGTGPDARHSFVVCLHVDLESLEIKCCNPQVQLFYELTDTMNKVWNKIQKR
GNLSTS--SAYSETMAGHVP-SSPVRSSVGTVPPDTSTCSPSADIGTTTEGDSIQAGDES
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITMKLFAPDPENKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------RPG
-EGWQSGHFEGVFLQCKEK----------------------------PVT--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RTFHKLSEGLMDGSPHFLHEILLSAQAF
DIVLYFPLLNAIASIFQTKLPR-QKEKRKSPGQPMRTHTVTSRNLPLIYINTSVIRIFVP
KTE-EIQS-TVGVNQAAKEDTMVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEKESATG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTESERNSQN
PALEWNMASSIRRNQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLVVANMTGLEPSHKATEISKQELK-------------
---------------------K-------------------------MDTFDGGMA----
------------------ETSSRYSGAQDSGIGSDSIKIRIVQIEQQSGASQHRIARPSR
QSSIVKNLNFIPFDIFITASRISLMTYSSRALPKLKS-QEQKEDGKTGKSSLNLPEVDS-
---DVAKLNQASISTVTAEDLFRSSTSLTSGRKIGVLSLESLHASTRSSARQALGVTIVR
QPGRRGTGDLQLEPFLCFIVSQPSLLLSCHHRKQRVEISVFDAVLKGVASDYKCTDLGKT
LPEGLDYSTV-WLQTVPGETDRKSGIPPSLVTLQLKDFLNGPADISLDISKPLKINLSFT
KLDQINHFLKKIKNAHSFAHH---EDTSALSGTMLNKDEPPVS-SFHGKLSKPKDHSDGV
RKISFQENTWRAISYFQKISVRTTQIVVSMEPVPHPNKPC-------LLASL--------
---------SNLNGSFSVKAAQKVPGI-ILGSSFLLSINDFLLKTSLKERSRILIGPLCV
TANLEAKWCKHSGNPSTEQSLPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLSGY
LNEERNFEAQVSEP-VPRMP-SMEKNQTFKSEQSSDDLRTGLFQYIQD---AEPLKLPGA
YEVLFHNETEDSPGMMLWRYPEPRVLILVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDEIQKVFVAFREFSLSESNVCELQLPDINLVNDQKKLVSS
DLWRIVLNSNQNGADDQSS--------ASESGSQSTCDPLITPTALAACTRVDSCFTPWF
VPSLCMSFQFAHLEFHLCHHLDQLGTA---------------------------------
----SPHYLQPFISDRNVPSELEYMIISFREPHLYLRQWNNGSICQEIRFAAQADCKLLE
CRNVTMQSVIKPFSISGQIAVSSDASGKLLDCTMRVDSVSANFGQHVVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3226)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGRTA

ENSGT00410000025397_2_Linker_1_2 (3226, 4166)

SLIIKVQRLSGVQKQ
IIISGRQIICSYLSESIELKVVQHYISQDGQAVVREHFDCLAPKKKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESRAMEDSTVIQVPSSNSSIIYVWCTVLTLEPNSQVQQRMIVFS
PLFIIRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLIHHLTFQAREEYDP
SDCAVPISTALIRQIATKIHPEGTVN-QILDDFYGPKKTLEPTWPYNKKDSDRN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAVKLVHNLTSPKWKDGGNGEVVTLDEEAFVDVEIRLGA
FPGHQKLCQFCISSMVQQGIQIIQIEDKTTIINNTPYHIFYKPQLSVSSPHS-GKEDFHI
PDSATFSICPGGEQLAVK--SSSLPCWDLMPDVGPLVLD--SSLLQKQILLGFSPAADAD
SSQCWSLPAIVRQEFPRQSVAVPFGNVRENGFCTRALALTYQEHFGVTYLTITEDPSPRV
IVHNRCPVTVLIKENIK--EIPNFEVYCRRIPPESSVHHELYHQISSYPDCKTKDLLPSL
SLRVDLLDAVTAEWSDAVDINGQGTQVVFLTGFGYVYVDIVHQCGTVLITVAPEGKAGPI
LTHTTRTLEKMVTFKVFITQLSVAVSDDLTDH-----RAS-SELLRLTLDDVFLHMAPVA
GALPGE-----EEPAAA------------LFHLYSMEICCGDLQLDNQLYNKSNFHFAVL
ICQ-----------EEKAE---PTQCP-RVSDLLVSSRDLEEYKENCFIKLCITLTEG--
KSFLLSVSELSFELKPARLYVEDTFVYYIKTVFDTYLPHSN-P-ASHPSQLCG----GAR
VLPLQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVTIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGTGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSVTNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSQLGISLLGAIAGIVDQPMQNFQKTSASQASAGCKAKDVISGVGKGL
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDQHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQYHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSE
QKHLLTMQLKQPRVACDVEVDGVRERLSEQQYNRLVDYIAKTSYHLAPTCSSMQTP-CPV
VAVDPPPSTVKAYRYLVDPHFAQVFISKFTMVKNKALRKGFS

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 103)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCGSNSTNRSTTENTKSS
IKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGSFKEGEIEDPTCHNKDM-LGNIT-GSEDETRIDMQYPTQYKGQEL
YSQQDEEQPQGWVSWAWSFVPAIVSYDDGEED---FVGNDPASTTHQQKAQALKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSQTEACFFICGENLSTKGFTYLTNSLFDYRSPENNGTR
AEFILDSTHHKETYTEIAGMQRFGAFYMDYLYTMENTSGKG--STNQQDFSSGKSEDLGT
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSRLKSDIKDENETILNPE
EVAFLEEYIPTRHTSVTLLKCTCTISMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIRILVDKINVEHSVPMYAEQLVHVVSSLTQPSDNLLHYCYVHCYLKIFGFQAGLTSL
DCSGSYCLPVPIIPSFSTALYGKLLKLPTYWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-LGSVSSSAVIEALINEVFLS-IEIG-----CCYVAQV--------DLEL
LASN----------------DPPTSTS---------------------------------
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-------------------------------------------------E

PF12624 // ENSGT00410000025397_2_Domain_0 (51, 110)

LKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCSSNST

ENSGT00410000025397_2_Linker_0_1 (110, 3075)

NRSNAENTKSS
TKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RVMQLGIALYYGEIGNLKDSDTEDPACHSKDA-AGNIA----DETRVDTQYPAQYKGQEL
YSQ-DCEEPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPASTLHQQKVPTLKDPIVSV
GFYCTKATVTFKLSEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVRDFEEHTNRSEMEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDGAHHKETYTEMAGMQRFGAFYMDYLYTVEHNSGKG--PVNQQDFPSGKNEDLGI
-VQEKSTKSL-------------------MVVCALEHEYEPYSGLKPESKDEKEMVPSPE
ELAALEEYIPTRHTSVTVLRCTCTIFMAEFNLLDRLLPVIMGGKNSSNFTNAANFQSLRP
LPSIQIVVDKINLEHSVPMYAEQLAHVVSSLSQPSDNLLHYCYVHCYLKVFGFQAGLTSL
SHGGSYFSPVPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTVL
LQAIYQSWSH-IGNAASSTVNEALMSEAFQT-PGVK-----SKNPLPTLEGSIQNAELKY
CSTALV--------------RSPGDNGKEKLIPLLQGPSDTRDLHSTKWLNESRKPESLL
APDLVAFTVQE-------------------------------------CAVFLCSVQGLA
VNIDPVLYTWVIYQPQKRTSRHMQQ------PVVSVPL-VPSVNRRKDEELSAGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLHIHEGCR-HPEERMKEFIGILWNAVKS
LTLQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSTPGTLVLCLPQIKIVSA
GHKCLQPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQ-------------
-------KLLPPGPHGRHSFVVCLHVDLESVEIKCSNPQVQLFYELVDTMSKVWNRIQKR
GNLGSS--SVYPETMAGPVP-SSPVRSSVGTALPDTSTCSPSADIVTTTEGDSVQAGDDS
PFSDSVTLEQTTSSIGGSSGRVSLWMQWVLPKLTVKLFAPDTGNKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNVDHYQS---------------------------RPG
E-GWQSGHFEGVFLQCKEK----------------------------PLT--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RGFHRLSEGFTDGSPHFLHEILLSAQAF
DIVLCFPLLNAMASIFQTKLPRAQKEKRKSTGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETRSA-V-EVNQAAKEDTLVLKVGSVAMAPQADNPLGRPVLRKDIYQRALNLGILRD
PGTEIEDRQKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXSILTPILTDFSVRITGAPAIIFTKIISPENLHMEEILVCGHS
LEVNITTNLDFFLSVTQVQLLHQLIAANMTGSEPPDKATETSKQEQK-------------
---------------------K-------------------------MDTFDGGIA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQCSGASQHRLARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSLLPIPRFKLPEQK-EDGKTAQSPLTPPEADS-
---DVAKPTQACVSMMTAEDLFSH--SLSSGKKPRVLSLESLHAATRSSARQALGVTVVR
QPGRRGTGXXXXXXFLYLIVSQPSLLLSCHHRKQRVEISVFDAVLKGVAPDYKCTDPGKT
LPEALDYNTV-WLQTVPGETDCKSGIPPSLVTLQIKDFLNGPADINLDVSKPLKANLSFT
KLDQINHFLKKIKKTHSFAHG---KEPSAPSDTVLSKDEPPISKGYRGKPCKPKVHSDGV
QKTSLQENMWRAVSCFQKVSVHTTQIVVSMETAPHPHKPC-------VLASL--------
---------SNLDYQV---------PE-VLGSSLILSISDLLLKTSLKERSRTLIGPFST
TVSLEAKWCKHSGNPGPQQSIPKIAMDLRGGLLQIF-----WGQEHLNCLALLHELLSGY
LKEEGKLEVPAPES-TPQMPSPVDKTQAFKSEQSSDDLRTGVFQYIQD---AEPLKLPGT
YEVLFCNETEESPGMMLWRYPEPRVLILVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVSDQKKLVSS
DLWRIVLNNNQNAADDQSS--------VSESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLGISFQCAHLELRLCHHLDQLGTA---------------------------------
----SPQHLQPFVSDKNVPSELEYMVISFKEPNLYLRQWNSDSVCQEIRFSSKVDCKLLE
CRNVTMQSVVNPFCVSGQMSLSSDGEQKMLDGTVIMDSVLVNFGQHAVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4228)

TASLIIKVRPLSGVQKQ
ILICGRQVICSYLSQSIELKVVQHHIGQDGQAVVREHFDCLTAKTKLPSYILENSELTEL
CVKAKGDEDWSRDVCLEPKASDYSTVIQVPASNSSIIYVWCTVLTLEPNSQVQQRMVVFS
PLFIMRSHLPDPIIIHLEKRSLGLRETQIIPGKGQENPLQNAEPDLVHHLTFQAREEHGP
SDCTV--------------------S-EMLDEFYGPEKFPEPIWPYSKKDSDRN---EQL
SQWDSPMRVKLSLWKPYVRTLLIELLPWALLINQSRWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNVMSPKWKDSSNGEVVTLDEEALVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQIIQIEDKTTVINNTPYQIFYKPQLSVASPCS-GKEHFHV
PDGATFSICPGGEHPAMK--SSSLPCWDFLPDVGPSV-D--TAALQKQILLGFSPAPGAD
SSQCWSLPAVVRREFPRQSVAVPFGTLRENGFCTRAVALTYQEHFGVTYLTLSEDPSPRV
IFHNRCPVAMLVKENMR--EIPKFEVYCKKIPPESSVHHELYHQIMGYPDCKTKDLLPSL
LLRIETLALSR-----------HALKVEFLLAFMSIYTAPS--WGTVH---KEEARDTNE
LCPSSRAPEKTVTFKLFLTRLSLAVSDDLTHH-----KTS-SELLRLTADNIFLHVCPAP
G---VLPGE---EPPAAL-----------LQ-LLSVEVHVGDLQLDNQLHNKSNFHFAVL
VCQ-----------GERPE---PVPFS-RVQSLLMSGKDLEEYKGSCFIKLCLTGSEGT-
DPGHP-----------------------------------------------------QQ
ILPVQTAQRR--LLAA--------------------LSSTDSSREEEWPFLVLP------
----------PSARWQAGGPLKAVGCW

PF16909 // ENSGT00410000025397_2_Domain_2 (4228, 4310)

VVGSLEILGSPATLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIIDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPRDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDTK
QNNLLTVQLKQPRVACDVEMDGARERLSEQQFNRLVDYIAKTSCHLAPSCNPMQTA-CSV
VAVEPPPATVKTYRYLVDPPFAQVFISKFTMVKNKALRKGFP

------------------------------------------------------------
------------------------------------------------------------
----------------------------------MLVEK---------------LNFT--
FCMQCIFLNYALLLKATDLVLRKMINFSDCTVCLDKRNASGKIEFYQEPLLYKCSFKTRL
HFTYDNLNSQEPLLYKCSFKTRLHFTYDNLNSKMPSIIKIHTLVESLKLSISDQQLPMFI
RIMQLGIALYYGEIGNFKDGESEDLICHTKDM-LGNIT-GAEEEASSVMQYPTQYISQDP
YLHQDDDQQQGWVSWAWSFVPAIVSYDDEEND---SGGIDDGTA-EKQKSQSLKDPIISV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVICWEQEGTTVEVLMKGELFFDCQIGFV
GCQAMCLKGIMGIKDFEDNMNRSDEEACFFNCGENLSVKGMTYLTNSLFDYRSPENNSIR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMESTSGKV--SGNQQDPSSVKSEDFGN
-VQEMSTKSLIVGPLNLRLDSSAVHRIMKMIVCALEHEYEPYSRTKPDIMDGSRAIPSSE
EVASLEEYIPTRLTTFTVLKCTIIIPVAEFNLLDHLLPIIMGEKNLSGLLNAASFQPLRP
LPSIRILVDKVNLEHSVPMYAEQLVHLVSSLGQPSDNLLHYCYSHCYLKIFGFQAALTSL
DSKGLYCIPVPVIPSFSTAVYGKVIKFPKYWTKRAHVPLTECIFELPNLTVQATRAQTLL
LQTIYQSWCHPVGNVSSVVVNEALLNEVFQT-SGVK-----SKNPLPTLEGSIQNVELKY
CGTSLVKCASGTVGSIKICAKAPGDGGKEKLIPLIQGPSDTRDLHSSKWLNESRKPESLL
APDLVAFTIQIPQYMDYCHNS---------------------------GAVLLSSVQGLA
INVDPVLYTWLIYQPQKRVSRHIQQ-----QSLGAVPLGVS-VTRKKEDEASVGSAPLPR
QQSNQASEYASSPVKTKTITESRPLSLPVKTMLNSSESC-RSPEERMKEFIGIVWNAVKC
LTLQLEVQSCCVFLPNESLPSPSTIVSGDIPGTVRNWYHGQASMPGTLVVCLPQIKIMSA
GHKHMEPLQEIPFVVLRPILEE---GDAFPWTISLHHFSIYTLLGQQMTLNLVEPMGCTS
TLAVTSQKLHPSGPESRHSFVVCLHVDLESLEIKCSNPQVQLLYELAEITNKVWNKIQRK
GVLYQSVSSVYTETMTGPAPPSSPVKSSIGTIPPDTSTYSPSADIGTTTEGDSLQGGDDS
PFSDSITLEQTTSNIGVSSGRVSLWMQWMLPKITVKFFAPDPRNNGT---EVCIVSELED
LSASV--DMQDVYTKIKCKIESFNIDHYRNRPGGDWQSGHFEGIFLQCREKLLLFRKSLG
EDSWSLGQYGGVFLSCTDKLNRRTLLVRPISKQDPFS----NFSGFFPST--TAKLLDGS
HQQHG-FLSLTYTKAVTKNVRHKLISRNER--RTFHKLSEGHTDGSPHFLHEILLSAQAF
DVVLCFPLLNAIASIFQARLPRSQKEKRKSPGQPMRTHALTSRNLPLIYINTGVIRVFFP
KNEEEHHI--AEANPSIKEDTLVLKIGSVSMAPQADNPLSRAVLRKDIYQRALNLGILRD
PGSEVEDRQYQIDLQSINIGTAYWNQLKPEKENGKG------------------------
--------------------------------------G---------------------
-------------------------------------------------VLTETERNSQN
PALEWNMASSIRRHQERRAILTPILTDFTVRITAAPAIIFTKIDTAENLHPEEILVCGHS
LEVNMTTNLDFFLNVAQVQLLQQLLQANMVGLEPSSSTTEVSKQEQ--------------
---------------------K-------------------------MDVADGGTV----
------------------ETSSRCSGAQDSGIGSDSVKIRIIQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDIFVTASRISLMTYSCTASPKSKSVQEQKDGEKISKSSLNLPETVSG
SSQDTKKPSQPCISSVTADDLLNSNPPLSAGRKAGLLSLESLHASTRSSARQALGITIVR
QPGRRGAGDVELQPFLCLVVSQPSVLLSCHHRKQKVEISVFDAGLKGVASDYKCTDPGKT
LPEALDYCKI-WLQTAAGEVDAKSGIPPPLITVQIKDFLNGPADVNVDISKPVKANLSFS
KLDQINQFLKKIIATNEDVPR---KEAASSAGIIPDEDVTLISRHSSTKDFLPAVHPNTV
QKASVQENLWQTLSCFQKISIHTVQMVVLMETIPHPSKPC-------LLVSV--------
---------SSLSGSLNIKTGHKTAG--IHGSSLVLDIKDFLLKTSLKERAKSLVGPFCC
SVNVEAKWCKHSGDPGPEQSIPKIYLDLRGGLLQVF-----WGQEHLNCLVLLQELLWQY
LAKKGSVETLIPEH-TYPTCFSTERNQASKTEHTSDDLRTGLFQYIQD---AEAQKLPSA
YEVVFYNETEDSPGMMLWRYPEPRVLTLVRINPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKSFVAFREFSLSESKVCELQLPSISLVSDQKELIAS
DLWRIVLNSSQNVADDQSS--------ESESGSQGACDQLVTPTALAACTRVDSCFTPWF
VPSLSVLIQFTCLEVHLCHHLDQLGTA---------------------------------
----PPKFLQPFLSDKSMPSELEYMIVSFDEPHVYLRQWNDESVFQEIQFSTQADCKLLE
CRNVTMQSVVKPFKIWGQTAVSSSTAGRLFDCTIMVDPIFISFGQYALHSLNTAIQAWQQ
NR-CPEAE-EFVFSHFVICNDTQETLRFGQVDT-DENILLATLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDNTGTFIRTIQYKGRTASLIIKVQQLSGVQKQ
ILICGRQTVCSYLSESIELKVVQHYISQDGQAVVKEHINCLAAKQKLPSYILENNELTEL
SVKSTGDEEWSQDVCLSSTHTEHSTVIQVPSSKSSITYVWCTILTLEPNSHVQQRLIVFS
PLFIVRSHLPDPIIIHIEKRSLGLNEMQVIPGKGQEKALQNIEPDLTHHLTFQAREEDDP
SECAVPISTALIKQIATKSHPGGNVS-QVLSEFYGTAGPPQPAWPYNRKDSDSN---EQL
SQWDSPMRVKLSVWKPCVKTLLIELLPWALLINQSKWDLWLFEGEKILLQVPSGKVILPP
NFEEAFQVGIYWANTNTVHKSVAIKLVHNVTSPKWKDADNGEVVTLDEEGFVEAEIKLGA
FPGHQKLCEFCISSMVRQGIQILQIEDKTTIINDTSYQIYYRPQLFISKPHS-GEEDFLA
AESAVFGVGPAGAG----GALGAVPCWDLLPEPGPSAAG--TPPGERRLLLSFSR-----
--QRWSLPAVLSAELARQSVAVPTGAR--SGLCTRAIALTYQEHLGVTYLTLTEDPSPRI
IIHNRCSIPLLVKENFK--DTPKFEVYCKKIPAECSVHHELYHQISSYPDCKTRDLLPSI
LLKVVSSDETVNEWSDFVDINNQGTQIVFLTGFGCVYVDITHHCGTIVITLAPEGRAGSA
GINLNRSQEQTLSLKMFVSQLSFAAFDDITNH-----KVS-SELLRLTADNVFLHMAPAT
SS---LSQELQQDSVEG------------LPQFHNLQVYCEDLQLDNQLYSKSNFHFAVL
LCQ-----------EEKNE---TAQWS-RMNNLIVCNKDLESYKENCFIKLCIAFSEG--
ENFMFHMNDLSFELKPARLYVEDTFVYYIKTLFDTYLPEN--KTACKSMS----ASDTTL
IVPEQVREHARALVKPVKLRKLKIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQE

PF09333 // ENSGT00410000025397_2_Domain_3 (4316, 4403)

EWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQRVSEAQASAGHKARGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRSHPNDQRVE-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVMIVSGSGQQHEGCLLLTSEVLFVVSISEDTQQQAFPVTEIDCLEDEQ
QKDLLKVQLKQQRVPSDLEAEGARERLSEQQYSRLVEYITKTSCHLAPSTATAPAP-Q-T
LATEQPLTITKTYHYVVDPNFAQVFISKFTMVKNKALRKGFH

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 110)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILKLKDGIQ-DDHESCSSNST

ENSGT00410000025397_2_Linker_0_1 (110, 3075)

NRSNAENTKSS
TKPRRIQQAAPTDPDLPP-GYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RVMQLGIALYYGEIGNLKDSDTEDPACHSKDA-AGNIA-GAEDETRVDTQYPAQYKGQEL
YSQ-DCEEPQGWVSWAWSFVPAIVSYDDGEED---YLGNDPASTLHQQKVPTLKDPIVSV
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVRDFEEHTNRSEMEACFFICGENLSTKGLTYLTNSLFDYRSPENNGTR
AEFILDGAHHKETYTEMAGMQRFGAFYMDYLYTVEHNSGKG--PVNQQDFPSGKNEDLGI
-VQEKSTKSLVIGPLDLRLDSSAVHRILKMVVCALEHEYEPYSGLKPESKDEKEMVPSPE
ELAALEEYIPTRHTSVTVLRCTCTIFMAEFNLLDRLLPVIMGGKNSSNFTNAANFQSLRP
LPSIQIVVDKINLEHSVPMYAEQLAHVVSSLSQPSDNLLHYCYVHCYLKVFGFQAGLTSL
SHGGSYFSPVPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTVL
LQAIYQSWSH-IGNAASSTVNEALMSEAFQT-PGVK-----SKNPLPTLEGSIQNAELKY
CSTALVRCASGTLGSIKICAKAPGDNGKEKLIPLLQGPSDTRDLHSTKWLNESRKPESLL
APDLVAFTVQVPQSMDDCHHS---------------------------GAVFLCSVQGLA
VNIDPVLYTWVIYQPQKRTSRHMQ------QPVVSVPLVPS-VNRRKDEELSAGSAPLAK
QQSYQASEYASSPVKTKTVTESRPLSVPVKAMLHIHEGCR-HPEERMKEFIGILWNAVKS
LTLQLDVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSTPGTLVLCLPQIKIVSA
GHKCLQPLQEIPFVIPRPILEE---GDAFPWTISLHHFSIYTLLGKQVTLSLVEPMGCTS
TLAVTSQKLLPPGPDGRHSFVVCLHVDLESVEIKCSNPQVQLFYELVDTMSKVWNRIQKR
GNLGSS--SVYPETMAGPVP-SSPVRSSVGTALPDTSTCSPSADIVTTTEGDSVQAGDDS
PFSDSVTLEQTTSSIGGSSGRVSLWMQWVLPKLTVKLFAPDTGNKGT---EVCMVSELED
LSASI--DVQDVYTKVKCKIESFNVDHYQS---------------------------RPG
-EGWQSGHFEGVFLQCKEKP----------------------------LX--TTKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLTSRNER--RGFHRLSEGFTDGSPHFLHEILLSAQAF
DIVLCFPLLNAMASIFQTKLPRAQKEKRKSTGQPMRTHTLTSRNLPLIYINTSVIRIFVP
QTEETRSA-V-EVNQAAKEDTLVLKVGSVAMAPQADNPLGRPVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWSQLKPEKGIGTG------------------------
--------------------------------------G---V-----------------
--------------------------------------------------LTESERNSQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENLHMEEILVCGHS
LEVNITTNLDFFLSVTQVQLLHQLIAANMTGSEPPDKATETSKQEQK-------------
---------------------K-------------------------MDTFDGGIA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQCSGASQHRLARPSH
QSSIVKNLNFIPFDIFITASRISLMTYSLLPIPRFKLPEQK-EDGKTGQSPLTPPEADS-
---DVAKPTQACVSMMTAEDLFSH--SLSSGKKPRVLSLESLHAATRSSARQALGVTVVR
QPGRRGTGDLELHPFLYLIVSQPSLLLSCHHRKQRVEISVFDAVLKGVAPDYKCTDPGKT
LPEALDYNTV-WLQTVPGETDCKSGIPPSLVTLQIKDFLNGPADINLDVSKPLKANLSFT
KLDQINHFLKKIKKTHSFAHG---KEPSAPSDTVLSKDEPPISKGYRGKPCKPKVHSDGV
QKTSLQENMWRAVSCFQKVSVHTTQIVVSMETAPHPHKPC-------VLASL--------
---------SNLDGSLSVKAAQKVPGL-SLGSSLILSISDLLLKTSLKERSRTLIGPFST
TVSLEAKWCKHSGNPGPQQSIPKIAMDLRGGLLQIF-----WGQEHLNCLALLHELLSGY
LKEEGKLEVPAPES-TPQMPSPVDKTQAFKSEQSSDDLRTGVFQYIQD---AEPLKLPGT
YEVLFCNETEESPGMMLWRYPEPRVLILVRITPVPFNTTEDPDISTADLGDVLQ------
------------VPCSLEYWDELQKVFVAFREFSLSESKVCELQLPDVNLVSDQKKLVSS
DLWRIVLNNNQNAADDQSS--------ASESGSQSTCEPLVTPTALAACTRVDSCFTPWF
VPSLGISFQCAHLELRLCHHLDQLGTA---------------------------------
----SPQHLQPFVSDKNVPSELEYMVISFKEPNLYLRQWNSDSVCQEIRFSSKVDCKLLE
CRNVTMQSVVNPFCVSGQMSLSSDGEQKMLDGTVIMDSVLVNFGQHAVHSLNTAIQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3224)

HFVICNDTQETLRFGQVDT-DENILLASLHSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYKGR

ENSGT00410000025397_2_Linker_1_2 (3224, 4168)

TASLIIKVRPLSGVQKQ
ILICGRQVICSYLSQSIELKVVQHHIGQDGQAVVREHFDCLTAKTKLPSYILENSELTEL
CVKAKGDEDWSRDVCLEPKASDYSTVIQVPASNSSIIYVWCTVLTLEPNSQVQQRMVVFS
PLFIMRSHLPDPIIIHLEKRSLGLRETQIIPGKGQENPLQNAEPDLVHHLTFQAREEHGP
SDCAVPIATALIKQIATKTQPGGTVS-EMLDEFYGPEKFPEPIWPYSKKDSDRN---EQL
SQWDSPMRVKLSLWKPYVRTLLIELLPWALLINQSRWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNVMSPKWKDSSNGEVVTLDEEALVDAEIRLGA
FPGHQKLCQFCISSMVQHGIQIIQIEDKTTVINNTPYQIFYKPQLSVASPCS-GKEHFHV
PDGATFSICPGGEHPAMK--SSSLPCWDFLPDVGPSV-D--TAALQKQILLGFSPAPGAD
SSQCWSLPAVVRREFPRQSVAVPFGTLRENGFCTRAVALTYQEHFGVTYLTLSEDPSPRV
IFHNRCPVAMLVKENMR--EIPKFEVYCKKIPPESSVHHELYHQIMGYPDCKTKDLLPSL
LLRIETAGEVVVEWSDAVDINSQGTQVVFLTGFGYVYVDIAHQCGTVIITVAPEGKAGPI
LTGIHRAPEKTVTFKLFLTRLSLAVSDDLTHH-----KTS-SELLRLTADNIFLHVCPAP
G---VLPGE---EPPAAL-----------LQ-LLSVEVHVGDLQLDNQLHNKSNFHFAVL
VCQ-----------GERPE---PVPFS-RVQSLLMSGKDLEEYKGSCFIKLCLTGSEG--
TECLFDVSEFSFELKPARLYVEDTFVYYVKTLFDTYLPHSR-L-AGHPARPCT----GRQ
VLPVQVRQHARALVNPVKLRRLVIQPV

PF16909 // ENSGT00410000025397_2_Domain_2 (4168, 4310)

SLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPRDLHAD-QAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITEIDCAQDTK
QNNLLTVQLKQPRVACDVEMDGARERLSEQQFNRLVDYIAKTSCHLAPSCNPMQTA-CSV
VAVEPPPATVKTYRYLVDPPFAQVFISKFTMVKNKALRKGFP

M

PF12624 // ENSGT00410000025397_2_Domain_0 (2, 92)

LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSG
HIHELRIHVPWTKLGSEPVVITINTMECILK

ENSGT00410000025397_2_Linker_0_1 (92, 3075)

LKDGIQ-MALASA----------------
----------FVPRQAEP-CYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAEC
YTVGELWDRAFMDISATDLVLRKVINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRT--
---------------------RLHFTYDNLNSKMPSVIKIHTLVESLKLSITDQQLPMFI
RIMQLGIALYYGEIGNFKDGETEDPTCHSKDM-LGNIT-GVEDETRIDMQYPAQYKGQEL
YSQQEDEQPQGWVSWAWSFVPAIVSYDDNEED---FLGNDPTSAMHQQKAQTLKDPIVSI
GFYCTKATVTFKLTEMQAESSYYSPQKVKSKEVLCWEQEGTTVEALMMGEPFFDCQIGFV
GCRAMCLKGIMGVKDFEENMNRSETEACFFICGENLSMKGLTYLTNSLFDYRSPENNGTR
AEFILDAAHHKETYTEIAGMQRFGAFYMDYLYTMENISGKG--SANQQDFSSGKSEDMGV
-VQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALEHEYEPYSGLKPDIKDENETTLNPE
EVASLEEYIPTRHTSITLLKCTCTIFMAEFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRP
LPSIQILVDKINLEHSVPMYAEQLVHVVSNLTQPSDNLLHYCYAHCYLKIFGFQAGLTSL
DCRGSYCLPVPIIPSFSTALYVKLLKLPTCWTKRSQIAITEGIFELPNLTIQATRAQTLL
LQAIYQSWSH-IGNVNSLSVNEALMNEVFQT-IGVK-----SKNPLPTLEGSIQNVELKY
CSTSLVKCASGTMGSIKICAKAPGDSGKEKLIPLLQGPSDTKDLHSSKWLNESRKPESLL
APDLIAFTVQVPQYMDYCRNS---------------------------GAVLLCSVQGLA
VNIDPVLYTWLIYQPQKRTSRHMQQ-----QPVVAVPLVVP-ISRRKEDEVSVGSAPLAK
QQSYQASEYASSPIKTKTITESRPLSVPVKAMLNISEGCR-SPEERMKEFIGVVWNAVKS
LTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQTSMPGMLVLCMPQIKIISA
GHKYMEPLQEIPFVIPRPILEE---GNAFPWTISLHHFSMYTLFGKQVTLCLVEPMGCTS
TLAVTSQKLLATGPDTRHSFVVCLHVDLESLQIKCSNPQVQLFYELTEIMNKVWNKIQRR
GNLSPS--SAYAETVAGPVP-GSPVRSSVGTAPPDTSTCSPSADVGTTTEGDSVQAGDDS
PFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKITIKLFAPDPENKGT---ELCMVSELED
LSASI--DVQDVYTKVKCKIESFNIDHYRS---------------------------SLG
EECWSLGQCGGVFLSCTDKLNRRTLLVRPISKQDPFS----NCSGFFPST--TAKLLDGS
HQ-QHGFLSLTYTKAVTKNVRHKLISRNER--RSFHKLSEGLTDGSPHFLHEILLSAQAF
DIVLCFPLLNAIASIFQAKLPRTQKEKRKSPGQPMRSHTLTSRSLPLIYINTSIIRIFVP
KTEEMQPS-I-EVNQAAKEDTMVLKIGSVAMAPQADNPLGRTVLRKDIYQRALNLGILRD
PGSEIEDRQYQIDLQSINIGTAQWDQLKPEK-----------------------------
---------------E----S---G----T---R----G---V----L---T----E---
S----E---R----N------------------------------------------SQN
PALEWNMASSIRRHQERRAILTPILTDFSVRITGAPAIIFTKIISPENMHTEEILVCGHS
LEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSSKATEISKQEQK-------------
---------------------K-------------------------MDTFDGNVA----
------------------ETSSRYSGAQDSGIGSDSVKIRIVQIEQHSGTSQHRIARPSR
QSSIVKNLNFIPFDVFITASRISLMTYSCTAIPKSKSQEHK-DDEKPGKSSLNLPEVDS-
---DVAKPSQPCISTVTAEDLLSSSVSFPSGKKIGVISLESLHASTRSSARQALGITIVR
QPGRRGAGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEISIFDAVLKGVASDYKCTDPGKT
LPESLDYCTV-WLQTVPGEIDSKSGIPPSLVTLQIKDFLNGPADINLDISKPLKANLSFT
KLDQINHFLKKIRSVH----S---KETSAPLDTMLNKDEFPASKCYRGKLSKPKVHGVGA
QKIPFQENLWRTISCFQKITVHTTQIVISMETVPHPNKPC-------LLASL--------
---------STLSGSLNVKAAQKVPGV-ILGSSFLLSINDFLLKTSLRERNRILIGPCCA
TVNLEAKWCKHSGNPGPEQSTPKISIDLRGGLLQVF-----WGQEHLNCLVLLHELLNGY
LHEERNIAVHVPEA-VPQMPSPIEKNQMFKSEQSSDDLRTGLFQYIRD---AEPLKMPGV
YEVLFYNETEDSPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDMLQ------
------------IPCSLEYWDELQKVFVAFQEFSLSESKVCELQLPDINLMNDQKKLVSS
DLWRIVLNSSQNGADDQSA--------TLLGNNHQVNFSNDPSLALAACTRVDSCFTPWF
VPSLCISFQFAHLEFHLCHHLDQLGTA---------------------------------
----PPQHLQPFISDKNVPSELEYMIIAFKEPHLYLRQWNNSSVCQEIRFSAQADCKLLE
CRNVTMQSVVKPFSIFGQIAVAHDAAEKLLDCTVIVDSIFVNFGQHVVHSLNTAVQAWQQ
NK-CPEVE-ELVFS

PF06650 // ENSGT00410000025397_2_Domain_1 (3075, 3233)

HFVICNDTQETLRFGQVDT-DENILLASLRSHQYSWRSHKSPQ---
------------------------------------------------------------
--------LLHICIEGWGNWRWSEPFGVDHAGTFIRTIQYKGRTASLIIKVQ

ENSGT00410000025397_2_Linker_1_2 (3233, 4166)

QLSGVQKQ
IIICGRQIICSYLSQSIELKVVQHYIGQDGEAVIREHFDCLTAKQKLPSYILENSELTEL
CVKAKGDEDWSRDVCLESKSPEYSIVIQVPSSNSSIFYVWCTVLTLEPNSQVQQRMIVFS
PLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHLTFQAREEDDP
SHCAVPISTSLIKQIATKIHPGCTVN-QILDEFYGPEKSLQPMWPYNEKDSDRN---EQL
SQWDSPMRVKLSVWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPP
NFQEAFQIGIYWANTNTVHKSVAIKLVHNLTSPKWKDGGNGEVVSLDEEGFVDAEIRLGA
FPGHQKLCQFCISSLVQQGIQIIQIEDKTMIINNMPYQIFYKPQLSVSKPHS-GKEYFHV
PDSATFSICAGGEQPAVQ--SSSLPCWDLMPDISQSPLD--ASMLQKQILLAFSPASGAN
SSQCWSLPAIVKQEFPRQSVAVPFGSCGENGFCTRAVALTYQEHFGVTYLTLSEDPSPRI
IFHNRCPVTILIKENIK--DIPKFEVYCRRIPSECSIHHELYHQISSYPDCKTKDLLPSL
FLRVECLGDTTTEWSDAIDINSQGTQVVFLTGFGYVYVDVVLQCSTVFITVAPEGKMGPI
LTATNRTLEKIVTFKMFVTQLSLVVFDDLTHH-----RVS-SELLRLTLDSVFLQMAPMT
G---HLRGE---EAAAAP-----------LR-PHCVEVYCGDLQLDNQLYNKSSFHFAVL
VCQ-----------GEKPE---PMQCP-KMQSLLVSSRELEEYKKNCFIKLCLTLTEGK-
NFLFDDINEFSFELKPARLYVEDTFVYYIRTLFRTYLPDGN-L-AGHPEVLTG----GKQ
VLPAQVRQHARALVNPVKLRKLVIQ

PF16909 // ENSGT00410000025397_2_Domain_2 (4166, 4310)

PVNLLVSIHASLKLYIASDHTPLSFSVFERGPVFT
TARQL--VHALAMHYAAGAL--FRAGWVVGSLEILGSPASLVRSVGNGIADFFRLPYEGL
TRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATSLARNMDRLSLDEEHYNRQEEWRRQ
LPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQRTSEAHASAGHKAKGVISGVGKGI
MGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRYQPSDLHAD-RAPNSHVKYVWKMLQ
SLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSVSEDTQQQAFPVTEIDCAQDSK
QNNLLIVQLRQPRVACDVEVDGARERLSEQQYNRLVDYITKTSCHLAPSCSSVQTA-CPV
VAVEPLPSTVKTYHYMADPHFAQVFISKFNMVKNKALRKGFP