Query Results 

------------------------------------------------------------
--------------------------------------------------------MRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCSRVGAP---------EVA-AAQCRCRLQ
DVLAQLRWETDGEQASRIRHLQAALDVERQLFLKYILEHFRGHPALSGAADP---PVVPS
SEEPSHET--------TAKSP-HQLGSL--DGGNAGAR----------------------
-------SPDSLLP----A--RASSLDSLARA-HSCSLGS-T-LSRPKT-----PEAS-S
PDTFIPGSPGPPPPPP-----------PS----EHRRPGDMREGEESGSKPCE-APS--P
LPQGEDYRELVKRNSELSEALQVLARHCSVLLEENLQVRRAGFPDEAREKVKRLKVKHAE
LASLARRLEDRARKL-QETNLRAVSAPVPG------ESLAGLELC-QAFARQRSRDLSEQ
ASALLAKDKQIEELRQECHLLQARAASGLGSAPLPGGGAA----CAEWLSF-SDLDRLQR
ESQREVLRLQRQLTLQQAT-SSGR--AEA-------------------------------
------------------------------GGQSAPCEEA-RRQVQALELELDARRRECE
ELGAQAAEARQGREDAEAQLQAALHEGAWLAKENARLQAQA--DWTRKVVAEDSEVHGQV
G--RTWQELENGGLLAG--QLLQQTA----------QGQDRQQQLQDDLQKALCDLQ--A
APEEMRTLQCQPAHPP-QEPRKAPQATEP---------PGRNSRGT------KLQSGPED
QTWSPPGRDKQEK------------------E---DFL------------LEKPVAPQEP
ARDPQE--------------PDREP--GSRARDSRPPAKKTSSTS--NSSS---------
---------E-VESMWATVP-SCPTL--DTAREVEDLEPDSVSSTQEVGD----------
-SEA-PATSKLRIFLARYSYNPFEGPNE

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPESELPLTAGEYVFIFGDMDEDGFYEGELED
GRWG--LVPSNLV---EQIPDPDILGCLPPAFP----DLG-------------PT--RLL
PGQG--------------KAL-------------KEDTGK--A-----------------
----------------------------------GKAQGAVD---RVPG-HMARLGSKTE
L-AREGSGTKT-GDGWLGPQRSADEWGF------------SKPLLG---ARRVFCVPPMQ
LRLQSVAATWAEITWVGS--NHSHMVYLNDLESALTPAGVSCYTFHHLHPGTRYQAQVE-
---VYLPQESLQGHWETMSSTITFNTPLAGPPDPPLDVLVEHH-TSPGLLVVSWLPVTID
SVGSSNGVQVTGYAVYADGLKVAEVTD---ATAGSTLIECSQLQLPLMCQKVSVRTMSLY
GESLDSVPAEIPHSCFPC-DRLPKMSPFSY------------------------TL----
------TFTLCP-------QR---LVLSPLSAKAN----------PYAPGNCGE------
----PQVKS--------LVAF--------------PEEPQK-------------------
---------------------------------SQAQGPADAQG----------------
------------------------------------------------------------
-------------------LCRKDLLFQKGPRNHGPPL-PRGQEWREES---HYQRH---
-------MGI---KQSPSAGVI-Q-LS---------------------------------
---PEGGPGKEPFQE---------------------------------------------
--------KAAL------------DKIPKQMQ------------------------NAP-
--------------------------LPLGT-SQQ---SVPDIY------DIL-------
--RE-EAGCFGL--------------WGSEGQEQRKVPRRQSR------------R-GL-
ALGGKRERC-----S---------------------------------------------
-------------------SLCPALSSKVVRM----SRGSAPPLGTRA-DPTNIFVALSD
YDPLGMSASPEAAEEELALRKGQLLRVWCSQDPHGFYRSEHDKQVGNIPGHLAAEVEADI
DCTG--TRWHLLGQGHPPSGAYLRDLGGLPS----P-----QHSSP--------------
-----------------RSQERP--SLWTPKTMLAALDYDPRDGP

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2612)

AGGSVKGMLSLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLIPAHLLDDMCFPRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTEDSPTPLGGSRTSPKRLGSPGQAAAVLEEQRRELEKLRVELEEERARGRAERRRFTAE
ARRVREAAERERQQLADHLHSKWEAQRFRELRQLQAEVQREREAEIRQLLRWKEAELRQL
QQLLGRERDGVVRQARDLQRQLAQELVNRGYCSCSGTP---------EVP-AEQCRCRLQ
EVLRQLRWETDGEQAARIRHLQAALDVERQLFLKHILEHFRWQPPLPGPPDP---QADNS
SEEPLLETAKS-ARR-TLKPP-LRLGAS------AAVR--------V-------------
-----RSRSLERLP----A--RASSLDFLAKA-SCCSLYS-T-LSCPKA-SESEAPAS-S
TDTFVAGSPNSSPPR------------------SHRKPKDPRGGEGCGNQPPE-GLT--P
SPLGRNYCALVKRNSELSEALQRLARCCSELREDNLQLRRGGGPRE-DEKVKRLKMKHAE
LAGLAQRLEDRARKL-QETNLRALSAPVLG------ENRAGLELC-QALARQRARDLSEQ
ASVLLAKDKQIEELKQECHLLQARVATGLDSPSHPAGGVP----HAQRLNF-SDLDRLQR
ESQREVLPLQRQLTLQQG-KACAR--SEV-------------------------------
------------------------------TSQSPHCEES-RRRVQALERELDAERRNSK
ALSVQAAAAQRHGEEAEAQLQAALCKGACLTEENERRQAQS--HWVRKVAGEKSDVHGQL
G--RACQERDAAGLLAE--QLLQQAA----------LGQNRQQQLQHDLQKALSDLQ--A
ARKELKTLQDQLGHLP-EQPQEATQALVS---------QATGGGRH------KFQSQAED
CAPSQPT---KEQ------------------PPVCPTL------------QEGPVPLGEP
ASSLLV--------------SDRVP--ANQHLDSRCQAKKTSSQS--TSFS---------
---------E-VESMWATVP-SCLTLDVDTASEVDDLEPDSVSPSLEVRD----------
-PEA-PSTSKLKIFQARYSYKPFEGPNEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPLTAGDYVYVFGDLDKDGFYEGELEN
GQQG--LVPSNLL---EQIPDSPYLSNLSPRSLESPNHLG-------------PT--ILP
VGQS--------------KAS-------------KEASLL--L-----------------
----------------------------------GEGQGSVD---RGPG-QVGREGSKTE
K-AIENLEIKK-ESCWLDSSQNIQEQSF------------CIPCLG---TKGLPFVGPTQ
LHLQRVTATSAEIAWVYGSSRHPHVVYLDDQEHALTPSGVSCYTFQGLHPGTQYQAQVEV
E--VGLPWDLEQVSWETVSSTITFNTPLAGPPDPPLDVLVEHH-TLPGFLVVTWIPVTID
SAGSSNGVQVTGYAVYADGLKVAEVTD---ATAGSTLLELSQLQVPLTCQKLSVRTMSLC
GESLDSVPAQIPEDCFIY-DLLPEIPPLSN------------------------TF----
------TFPIYH-------QK---MVLASLNTRVG----------PHSPESCGE------
----PQAKF--------PEVL--------------PEEPLRKHPPL-SNLSSEE------
A------G-------------------------KQAQGPTEVQK----------------
------------------------------------------------------------
-------------------GCRKDLPFQKSPQNHRPLP-PSGQSVIEEN---HYG-H---
-------MNT---SKGSSPCFN-H-LS---------------------------------
---PKCGPRKELCQE---------------------------------------------
--------KAAH------------EKALRQKQ------------------------DAQV
ST-----------------------PSQQGT-SQQ---YAADSY------NIL-------
--EEE--MILAP--------------WYTGTQEQKEKLGPQCR------------Q-GQ-
A-------L-----V---------------------------------------------
-------------------GKK------ECQL----YPAPSNKLGPEANTPARI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YNPLAMSANPKAAEKDLAFQKGQFLRAWGSQDPYCFYHAECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2510)

VEVGT
EQPD--RRWHLPAQGHLPSVDHLEDFEGPTR----P-----QVSFLRPQ-----------
-----------------GNSRGP--ALWTPKTMMVALDYDPRDRKAGSR

PF07653 // ENSGT00390000017228_1_Domain_5 (2510, 2612)

AKGKLALRAGD
VVTVFGPVDDKGFYY---------------------------------------------
-------------------GELGGHRGLIPAHLLDDLSVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQLGDP---GA---
----------------------------------------------MEPWTLPAWRCWTQ
---GQGCEPGDATPSIAGT--TVLQVRGLRSE------ENSE----PEGAHSPGPIGNTD
PEGTETGLPKPGQQTENPG-----------YSGP--GLEDE---------EAQ--A---Y
-KAKLNVGFGVRSNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVLRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------PQGPTALSR------------V
GAPA--PGAPGE----A----ILQEDVDSPQVVLGEP--EKQQRVRQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVKQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVQRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPHCCCST---PQP--------GPKDLDLP
PGSP-GRCTPKSSEPAL---------ATLAGVPRRT-AKKVESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-SEGNSGGARIQVFLARYSYNPLEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DMSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRRLVLLKQLAHSVVLA---WELPP---ERIDLRGFHVFVN---GELR-QALGPGVPPK
A-VLENMDLRT-GPH-HVSVQALTSRGN------------SDPLRCCLAVGAGAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECTPARPSTYWATFCHLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQVEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQTCHEVTVRTMSPH
GESTDSIPAPVAPALA-PACQPARMSCLS-----PRPSPEARTALASVSPGLGDPNFP--
---LRHPAPHGT-------QDSP----ASLPMETS---KGSQE-EP--AVSCGQE-----
------------------ESRATVPGTSEEKRAIEPTLGQEGSCPVAPSLAKQQVEWTSG
E-TGPTPCS---TQGEPTQK---APSTEACHGGDLGSGLKHRTEKEDTS--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE---------EEEQELNSRPCSPQKQVA---GNSIRENGAKP
---Q----PDPLCETDSDEEILEQILELPLQQLCRKKLF-SIPEEEEEE--------EEE
-EG--------QEKPDPSQPELALLG-LDCDSSQPQ----GPGLCPLS------------
-SEPSGAR---EYLEDVLGV---AGGN-SRRRGGGS-----------PEKPPNRKRP--Q
DPREHCSRLLGNG-GPQTTARPG----PPRERGSLPVIEGIRVGQEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPTDGEPWGTAAIGRSRGP----------------------
---QKVNSGSNPYVR--LPAWEKGEPERRGRCATGRT------KEPPSRAT-ETGESRG-
QDNSGRRGAQR----RG--ARVSRPGTTELVAG-PDSGDPP-EAPAHQNLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDSDGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLPPDVLPEGS--GNGPSIYSSTH-MTGPPRKPRRSKKVELEG--
-L-----QPCPGPPKL----V-HPAVLKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPKENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--ESG-TSQA
ESQRTRMR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------GFLVSQNMKLLSALEDLRHRCSSLTEENSLLRRSCFPET-EEKVKHLKRKNAE
LAVIAKRLEERARKL-QEANLKVVTAPVPLK-------GSSLELCKKAFARQRAKDLTEQ
ASALLAKDKQIEALQQECRELQAKL-I-------A--GKG----DPRCLNV-VEFDRLLR
ESQKEVLRLQRQIALKNFKECLRSSX--S---------LARCSELRF-------VAPV-L
LLPFF-SFLEDS----L----ENR

PF08499 // ENSGT00390000017228_1_Domain_0 (685, 754)

QMLDTE---------DELREMRSDAVPSEVRDWLAA
TFTQQARAKGRRAEEKEIQLQEVQSENARLAEE

ENSGT00390000017228_1_Linker_0_1 (754, 1093)

NLQLSEKA--GWAGQVESENADLKLQV
V--LVTKERDSVIQRNQ--GLQTKLENLEQVLKHMRDVAERRQLLEAEHKEALLVLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLES--TLDCMQARVKDLEDQCRSQTEQFSLLSQE
LKQFRLQTGKIDLL---TSTLVTSEL----PLALCSST---PQPHWD---E-GNCWRCLR
VFCQ-MGRCKENSSGPA---------LLAHQSTKKKQARKVESQS--SSSK---------
-----------SESMQNSS-KSCPTPEVDTASEMEELDVDSISLMPE-------------
--PGSQGPAKLQ

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

VFLARYSYNPFDGPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLMTVLPSELN--DLTHS-------------SYQEKSF
VSASTS--------SGDKSDFSIE---------ESSISPLV--SRAEGDQEERVSHTA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRKLTLIKQLARSVVVG---WEPPLLPAGCPDIQSYNIYVD---EELR-QNVKSGFQTK
A-VIEKLDLKT-KAY-RVSVQSVTEKGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDKLRCTFFVGQDLCVAPTM
LKVRNITATSAEVTWLPCNSNYNHAVYLNGEECDITKPGVYWYTFCNLQPNTQYVAKLEA
R-PLKTLWEEVSEGQEQNSAVIHFTTPLAGTPDAPLDVQVEVG-PSPGILVISWLPVTID
AEGSSNGVRVTGYAVYADGQKAIEVTS---PTAGSVLVDLSQLQMFQVCREVSVRTMSLY
GESMDSVPAQISSVLL-RASHCSSPSDSA-----------VSTTFT--SRLPRGESRG--
---SL-PA--RSPPAHQKASSPLQLSLSSASLVHT---SGTSL-----------------
--QGSDAAQDKKCLTV---PPQ--QAGS----TKLPAEG-TEPVSSR--LGAERDLPTNG
DESSPVWCSFCD----ERELGP-VGIMTVNRGSMCSELGRRRQQEE--KMSEIGRRQLTL
FAEHNRSSDLSDILEEEEEDEL------------SSEALYEKKWDP--REPCYRENGEKP
--------KMDLCDTDSDEEILERILELPLQKNHSKKLF-SIPEVTEDEDEDEEEKENPQ
GSLEAPTYIAGRSEKPLSTQDPFPKA-DGSDSSPDLSAQTPREE----------------
--------------------------QTAKKKGNNYR----EKIRG----RPEMGRKRQN
DSTEHCSRLLGNCSQM--GGGLYRAPSL-REELNIVSSSAGKEGFDVYTRARQSASR---
---------RN-------YG---FAEPAGMA-AHCYSSRSLEID------IEYDSED-DQ
DSTCSSPPESRLWPEGAQNCQRE---WSDCSSQSEAIHTDGRRNLTRLERVEEQGEGSTE
AS-GNKDPRGQELPG--SATWQT--PSRRGSRSLRRC------QMQKPLLS-SPG-----
-----------------------------------PPRSSA-SETTVKDDGI

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RIFVALFD
YDPVSMSPNPDAAEEELPFKEGQILKVCGDKDADGFYRGECAGREGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VQVEN
NEI----KMQLLKQGFLPADPPTDSI--GNGTFSSPPRR-QTVPPPKPRRSKKEEMGLSK
Q-----------FCPTGQKHQDFEAELLTP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RSMVAVFDYNPKESSPNADAEAELTFSAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNQQRGLVPSNFLEAVTSDGDVVEELHSKDKD-------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

-TKDYPNPLGGGRASPKKPGSPGPAAAVLEEQRRELEKLRAELEAERARGRAERRRFAAQ
ERQLREAGERERQQLADHLRSKWEAQRCRELRQLQEAVLREREAEIRQLLRWKEAEMRQL
QQVLHRERDGVVRQARELQRQLAEELVNRGHCRRAGAP---------EAA-AAQCGCRLQ
DVLAQLRWETDGEQAARIRHLQAELDVSRQLFLKYILEHFRWRPALSAPPEP---RAVHV
SEEPQPEAASR-RPE-P----TCRRGSL--HSLSTGTR--------VRSRSLDLART---
---ARSSSSGGLLP----T--RASSVDSLSPA-QSGSLDS-T-WSRPKD-SKPEERTSSL
PDASIPDSPPPS--------SSPPPPPPPLPPLEHRKAGDPRGGEGSGSQACE-ALT--S
-SLSLDYPALVKRNSELAEALHVLARRCSVLSEENSQLRRAGVPDQADEKVKQLKVKNAK
LSGLARRLEDRARKL-QETNLRAMSAPVPG------ESRADLGLC-QAFVRQCTRDLAEQ
ASALQAKDKQIEELRQECHQLQARFASGLASSPLPGGGAP----GTQLLSV-SDLDRLLR
ESQREVLRLQRQLTVQQGQ-GGAR--AQA-------------------------------
------------------------------GVQSAPCEEA-RRQVQELECELGARRRECE
ELGAQAAAARRRGDEAEAQLEAALREGAWLAEENARLQAQA--DCVRKVEAENSDVRGQL
G--RACQERNAAGLLAE--QLLQQAA----------RGQDRQQQLQHDLKNALRDLQ--A
AREEIRALQCQPQ--------EATQVPKS---------QARGSRRP------KHQPGLED
QALSPPSRDKQNR---------------------EASP------------PESQVALGKP
ASDPQV--------------PTRVP--ADWPPNSRPQARKAS--S--NSSS---------
---------E-MESVWATVP-SCPNLDLDTASEVDDLELDNVSPTLDIGG----------
-LEA-HTTSKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLARYSYNPFEGPNEHPKGELPLTAGNYLYIFGDMDEDGFYKGELED
GPQG--LVPSNLV---EQVPNSDILDCLPSKSP----NLD-------------PI--SLP
AGQG--------------RAS-QE---------DTSLSLL--P-----------------
----------------------------------GKSQAAAD---TGSY-PVTKVGSKTE
V-AVGIVDATM-EAYRLGLLQHVGEPGF------------SRALLG---CRGPLCVAPMQ
LGLQSVTATSVEITWVCSSSSHPHMVYLDDQEHALTPAGVSCYTFHSLCPATRYQARVE-
---VQLPWDLLQLPWETMSSTITFATPLAGPPDPPLDVLVEH-HSSPGLFVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKIAEVAD---ATAGSTLLDFSRLQVPLTCQKVSVRTMSLC
GESLDSVPAQIPADCFTC-HRLHKTSPFDYT--------------------FGDPSTC--
----RVTFPVCA-------QN---PSLAPLSAKAN----------PHAPRSCGG------
----PQVEF--------LGAF--------------PEEPPRRWSPV-PTLSSEGQCPCSG
A------S-------------------------SQAQGPREAWE----------------
------------------------------------------------------------
-------------------VCRKDLLFQKSVQDHRQPL-PGSQAVGEEN---HYQ-D---
-------MGT---SKTLAPGRM-H-PS---------------------------------
---PECGSMKTLCQC---------------------------------------------
--------NASL------------EKALRQKQ------------------------DAQI
SG-----------------------PAQQGA-SQQ---YVSDCH------KM--------
--LEEKEVCVHA--------------WGAKPQGQREALRTQSG------------Q-GQ-
ALGGKQQHQIHEPSS---------------------------------------------
-------------------VLCPALSSKVIEM----SRVDPTWLGQESDSPA

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YDPLVMSANPQAAEEKLAFQKGQLLRVWGSQDPNGFYRGECGGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

SKAGV
EWTN--GRRHLLAQGHLSSV----------------------GSFPMAQ-----------
-----------------RNPRRL--PSWTP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

KTMMAALDYDPRDRQAEGRAKDKLALRAGD
MVTVYGPVDDQGFYY---------------------------------------------
-------------------GESGGHWGLVPAHLLDYMSFH--------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTYPRLGDP---GA---
----------------------------------------------MEPWALPAWQSWTR
---GQGGEPGDTAPNIADTP-EALQVREVS--------------SQPQGAQSLVPVVGAD
PGGAEAGLPSLKQQAGSAG-----------CGCP--RLEAE---------EVQ--A---V
SKTMLDTGFGDQPNLELLRALGELQQRCAILKEENQMLRNTSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQQECRELQARLTL-------V--GKE----GRQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPSPPPPPR---------LPGPAVPSR------------A
GAPK--PVALGE----A----TPQEDVDSPPVVVEDP--EKQRRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKEAQNENARLLEENSRLSGRA--TKKEQVEWENVELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEEVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHRPLPCCCST---PQPCRA---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-TEGNPRGSRIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPLELA--DLSHS-------------SGPELSF
LSRGGGGSS-----SGGHSQPRPEEE---DAGDELSLSPP---------PEGLGAL-AVP
YPRHLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGARAGVVPSQ
LRVRRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPPQGAWEPGWERPEHRASTLQFTTLPAGAPDAPLDVQIEPG-PSPGILLISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVTVRTMSPH
GESADSIPAPVAPALA-STCSSARVACPS-----PRPSPEARTPLALASPGPGDPTSP--
---LWHTALHGT-------PDP--------TREMP---KGAQE-EP--GTPCPQ------
-----------------EVAGAALLGASEERRASEPTMGEGSPGPAAPCRAMQEAEWTTG
E-ASPTVCP---SQ-----K---APSTEACHGSDPG--LRARAEREDTA--ELGVRLVNP
LVDHGRNSDLSDIQEEEEE--------EEEEEDLASRTCLFQKQVA---GSSIRESGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEED-------
SEEQE-KPGAGCSSQDPSPPEPASLG-LGCDSGQPP----GLGLCPLS------------
-PEPSRAR---DPLEDVPGL---AGGS-SRRRGGGS-----------PEKPPNRRRP--P
DPREHCSRLLSNG-GPQASTR----PAPLRDRSGLPVIEGTRGGLESSGKARPGTS----
-------------R-RYARGRA----PESGL-ASCLYPKGLEIS------IEYDSED-EQ
DVGS-GGI-----SITSSCYPTDGEPWGTAPLGRPRGP----------------------
---LKVNSGPNHYPH--LPAWEKGEPERRGRSTTSRA------EEPPSRAAEETGEARG-
PGSCGRKGPHR----RG--TRAPRPGTAEL----APPRSPP-ETLAHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLFQRGYLSPDTVTEG----SSPFVYSEAH-TTGPPPKPRRSKKAELEG--
-P----VQLCPGPPEP----V-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELSFRAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPRPEVGS------PSRELT-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRLGDP---RA---
----------------------------------------------MEPWALPAWQSWTP
---GQGSDPGGRTLSIADIP-AALQGGELKPE------ESSQ----PEGAQSPGAMGGTE
PEGTKTGLPGLRHQAVSSR-----------PSCP--RREDE---------EVE--A---L
PKGKLNTGCGDRPDLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPMPRP-------GASLELCQKALAHQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPP---RPIR---------PAGP-AATA---RA--GA----
--PA--PGAPGE----A----TPQEDVENLPAVLGEP--ERQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQVRVRELEEQCRTQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGYSTLGDHPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPVP---------TTVTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-SEGSRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGGSSGGQSSGGRSQPRPEDE---AAGDELSLSPQ---------PEGLGGPPAVP
YPRSLVVLRQLAHSVVLA---WEPPP---ERLELRGYHICVN---GELH-QALGPGVPPK
A-VLENLDLRA-GPL-HVSVQALTSQGS------------SDPLRCCLVVGTQARVGPSQ
LRVHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRESRGPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGIVVISWLPVTID
AVGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCSKVTVRTMSPH
GESADSIPAPVPPALV-AACLPVTVSCPS-----PRPGSEARLPLAPASPGPGDPSSP--
---LRRPDSCGT-------REPPGGPPARET---P---KGSHEEEP--IVSCSQ------
-----------------KEAAAAVLGASEDGRASEPTGGARAPDPAALPLAKED------
--ALRAPCS---SQGALAQQ---VTCAEACLGGDTGSGPRPRAEREDAA--ELGGRLVNS
LVDHGRNSDLSDIQEEEEE---------EEEEELGSTTCSFQKQVV---GHSIRENGAKP
QS-Q----PEPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEEDEEE---D
EEDEE-RPGTGCSSRNPGPPEPAALG-LSCDSSQPR----GPGPCPLS------------
-PEPCRAG---DRLEDVPGL---VGGT-SRRRGSGS-----------PEKPPNRRRS--P
DPREHCSRLLSN--GPQASGR----PGPTRERGSPTVGEGTKGVPDTGGRGRPPPS----
-------------R-RCSRGRA----PESSL-ASCLSTRCLEIS------IEYDSED-EQ
EAGS-GGV-----SITSSCSLGDGEAWGTAPTGRSRGP----------------------
---LKANSGPNPYSR--LLVWEKGEPERRGRSATGRA------KEPPSRAT-ETGEPRG-
QDGSGRRGPLR----RG--VQAPRACTTEL----APLRSPPEEAMVYQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGDGRMGYVPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2494)

VAVDS
PVE----RQQLFQRGYLSLDVLSEG--SGNGPFVYATAR-TAGPPPKPRRSKKAEVDS--
-A----AQPCAGHIQH----V-SSASLKSPRTM

PF00018 // ENSGT00390000017228_1_Domain_5 (2494, 2611)

VAAFDYNPRESSPNMDVEAELPFQAGD
IITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEASS------SDREPG-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPGSPGPAAAVLEEQRRELEKLRAELEAERARGRAERRRFATQ
SRQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHQERDVIVRQARELQRQLAQELVNRGYCGRSGAP---------EAP-AAQCHCRLQ
EVLALLRWETDGEQAARIRHLQAALDAERQLFCKYIVDHFRWQPALREPTDP---QAAHS
LEEPPLEAQSN-TRG-TPKPA-RRLGSL--ESLSSGVR----------------------
-----VSSPNDLLP----T--RASSLEYLATA-HSCSLDS-T-LSCPRA-SESEIGAS-S
TSVPISDTSSPHPPPQ----------LPS----IHRKPTDLQ-EERPENK----------
--PGQDYNELVRQNSELAEALQVLVRRCCDLRE-NLQLRRAGFSDEADEKVKWFKVKHAE
LTDLAQRLEDRARKL-QETNLRAVSAPVPG------ESLED--LG-QVFARHRAQDLSEQ
AGVLQAKDLQIEALRRECHLLLALIAADLGSFSLPGEGAT----CAQWCNI-NDLDRLQR
ESQREVLRLQRQLTLHQSKAGGAR--ADA-------------------------------
------------------------------GSLSSPSETA-RHQVQALEQQLGAQRRECE
KLSAQAAAAERRYEETEAQLQAALHKGARLSEENMRLQALA--TWVKKMAQENSSVPRQQ
SHARLRQELEANGLLAE--QLLQQAG----------YVQDRWWQLQHYQNKAPSDLQ--A
SGKEMQGLQCQPGHPP-ET-LETTQASES---------QARGSRRS------KFKPKSEE
HELSLPTRDIQ-P-------------------PVCLSQ------------QENSVTLGEP
AGVLQV--------------SDKMP--TSQPLDSRPQAKKTSSHS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSVSTPLEARS----------
-AEA-PTTPKLKIFLARYSNNPFEGPREH

PF14604 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

SQGELPLTAGDYVYVFGDMNEDGFYEGELVN
GQRG--LVPSNLV---EQVSGSPVLSHLLPKSP----ELG-------------PT--ALP
AEHS--------------KAL-------------KKGTLL--L-----------------
----------------------------------GEVQGSLE---RGLC-QVGRADSKTD
T-AVKILETKT-EACWLDLKPSMDEQSF------------SRPLLE---AKGVFCLAPMQ
LRLQNVTANSATIMWASGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLHPGTRYRVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHH-ASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLHVPLACQKVSVRTMSLY
GESLDSVPAQIPEDCFSC-YPFLETPPFSLT--------------------DGDP-----
-------ST-CR-------QK---LVQASLATKPG----------PHNPGSCEE------
----PQAKF--------LEAF--------------PEEPPRKHSPV-SDLSSEG------
A------D-------------------------KQVQVPTEAWK----------------
------------------------------------------------------------
-------------------DYEKGPSCQESSQNHKPPL-IFGQSGVEEN---CSL-H---
-------LCI---SGRPTPGFI-H-LS---------------------------------
---PEIGPREVACSE---------------------------------------------
--------KPDL------------EKALLQKQ------------------------YAPM
LP-----------------------AHQPGS-ILC---LAADLH------HVL-------
--EEKEALCLSS--------------RCTEKLGQRKTKV-QSG------------Q-SPE
TPGGERE-----------------------------------------------------
-------------------LLCPVPASKVIKV----ASGGPEQLGPEANSSVRVFMALFD
HSPLVMSVNAKA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2396)

AEEELVFRKGQLLRVWGSRDPHGFYRGECNGQVGKVPGHLVAEVEVGT
EQTG--GRWQFPPQGHLHSEAQHEDLERLTN----F-----QGSF-GPQ-----------
-----------------GNPRTP--TLWTPKTMVAALDYDPRDGRAGVRAKGKLVLRTGD
VVTVYGPVDHKGFYY---------------------------------------------
-------------------GEYCGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPSPSGGGRATPKKPGSPGPSAVVLEEQRRELEKLRAELETERARGRAERQRFASQ
ARQLREAAERERQQLVDHLRSKWEAQRGRELRQLQEEVLREREAEIRQLLRWKEAEMRQL
RQLLHRERDGVMRQARELQRQLAEELVNRGYCGRAGAP---------EVA-AAQCRCRLQ
EVLAQLRWETDGEQASRIRHLQAALDVERQLFLKYILEHFRWHPALPGSPDP---QAVHS
SEGPPGDTVAD-SDG-PPKIM-CRLESLNADSLTGGVR--------LRSRSLDVVRA---
---GRSNSSNSLLH----T--RASSLDSLPPA-RSRSLDS-T-LGCPKA-PESEERAS-S
PDASVLGSPSAPAPPPPPPP----PPPPPPPPSEHRRPSDPP-E-DPGSQPCE-ALT--P
SSPGLDYQELVKQNSELSKALRAVARRCSGLREENTQLRRAGFQDKSDEKVKRLKVKHAK
LTGLARRLEDRARKL-QETNLRAVSAPVPG------DSRASLELC-QAFSRQRARDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGFGSVLHPGRGAAQAQVQAQWLDI-SELDRLQR
ESQREVLRLQRQLTRQQAS-GSAR--VEA-------------------------------
------------------------------DGQGAPSEEA-RRQVQALELELGARRRECE
ELSAQAAAAQRRGDEAEAQLQAALREGAWLTQENARLQAQA--DWTQKVAAENDDVRGQL
D--RACQERDAASMLAE--QLLQQAA----------RGQDRQQQLQHDLRKALHDLQ--A
AREEMLALQCQPGHPP-PEPQEAPQVPES---------QVRDPGRT------KFQPDPPD
QASSEPSRDKREN--------------------QEASR------------PGSPVAIREP
ASAPQM--------------PDRVL--ASPPLDSRYQAKKTSSQS--NSSS---------
---------E-VESAWATVP-SCPTLDMDTASEMEDLEPDSMSSTLEVGG----------
-SEA-RLPPKLKIFLARYSYNPFKGPNEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPLTAGDYVYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSDILDCLPLKSP----DFG-------------PT--RLP
PGQS--------------KGL-TE---------DTGHSFL--P-----------------
----------------------------------GKAQGAMD---KGPC-LMVGVAPKTE
G-AAEITDAKT-EDSWLGALQCMKEKGF------------SRPLLG---ATGALCMAPMQ
LHLQSVAATSAKIAWVYGSSSHLHMVYLNGQEHALTPAGVSSYTFHGLLPGTRYRAWVE-
---VRLPWDSLQVHWKTSSSTITFKTPLAGPPDPPLDVLVER-HASPGLLMVSWLPVTID
SAGSSNGVQVTGYAIYADGLKVAEVTD---ATAGSTLLEYSQLQQPLLCQSVSVRTMSLC
GESLDSVPAQIPHDCFTC-HQLPETSSFSHP--------------------CGDPSTC--
----RVTVPVCS-------QR---LTLSPLSATVS----------PHAPGSCGE------
----SQAEF--------LEAF--------------SEEPLRRQSPM-PNLDPEKECASAG
C------S-------------------------RQAQGPPETQE----------------
------------------------------------------------------------
-------------------VCRKDLLFQQSSPNHRPPL-PIGQSRGED----RYC-H---
-------MGP---RQSPASGVI-H-PF---------------------------------
---PERGLNKEIYQE---------------------------------------------
--------KSAL------------EKVLRQKQ------------------------DTQV
IV-----------------------PLRLDA-SQP---YVSDFH------DIQDV-----
-MQEEAAMCFSP--------------WGTRRREQRREFRTQNG------------R-GQ-
ALGGKRMCQLREPSP---------------------------------------------
-------------------ALCPAPSSKVMKM----PRGGPSPLGTGGDTLVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YNPLVMSANPEVAEEELAFQKGQLLRVWGSQDPCGFYHGECNGQVGTIPGHLVA

ENSGT00390000017228_1_Linker_3_5 (2395, 2506)

EVKVGT
EQTD--GKWHLPVQGYLPPMAPFDDFGGLTS----P-----QSSFPMPQ-----------
-----------------GNPRMS--SLWTPTTMMAALDYDPKDGR

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2611)

AGGQVKDKLSLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHLTLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGNAAPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PTCQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEQS-TLDSMQARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HLSVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLPPGTPYQAQVEA
QLPPQGPWEPGWERLEHRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----LRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGTAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAKWTAG
E-ACPAPSS---AQGALAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGGHLVNS
LVDHSRNSDLSDIQEEEEE--------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KPGAGCSSQEPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEVWGTATIGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSGSGNGPFVCSTAR-TTGPPPKPRRSKKAESEG--
-S----AQPCPGPPKL----V-ASAELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TPQ-
-AESQ-RT----RR-RRV------Q------------C----------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPADP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGGEPGDADPSIADTPPAALQVRELRLE------ESSK----PKGAWSSGPVGAID
PEGAEAGLPGLGQQAVSSG-----------PGCP--RLEDE---------EVE--P---F
PKAKLNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVPRP-------GTTLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDCDRLLR
ESQREVLRLQRQIALRNQQEP--S-PPSR---------SPGSVAPAR-AG-----A----
--PA--PGAPGE----A----TPQEYVDNPPVILGEP--EKQQRVQQLESELTKKRKKCE
SLEHEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAR-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDCGALGDHPTPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLAGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSISLLPA-A-----------
-PESSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGAQSSAGRSQPRLEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGATPK
A-VLENLDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGLVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPRGPWELGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSSGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLHMCREVAVRTMSPH
GESADSIPAPVAPALGAPACLPARVSCPS-----PRPSPEARPPLAAASPGPGDSSSP--
---LQHSVSHGT-------QEPLGGSPASPPGEML---KGSRE-EP--PAPCAQ------
-----------------EEAGAAVQGALEERRVSEPAQRERAPGPAAPSLAEQEAEWTSG
E-ARPAPCS---TQGVVAQR---VPSPEACQGGDTGSGLRPRAEKEDAA--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE---------EEEDERGSRTCSFQKQVA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEE----------E
EEEEE-KPGAGCSSQDPGLPEPVLLG-QGCDSGQPR----GPGQCPLS------------
-PEPSRAG---DHLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNG-GPQASAR----PGPARERGGLPVVEGTRGGPEAGGRGRPGSS----
-------------R-RCPRGQA----LESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----SITSSCYHGDGEAWGAAAVGKSRGP----------------------
---VKVNSGPNPYPR--LPAWEKGEPERRGRSATGRT------KEPPSRPA-ETGEPRG-
QDSSGRRGPQR----RG--TRAPRPGTTEL----APPRSPP-EMLAYQDLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
SAG----RQQLLQRGYLSPDVLVEG--SGNGSFVYSTAR-TTGPPPKPRRAKKAELEG--
-P----AQPCPGPLKP----I-PSSDLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPK-IPQT
ESQRMRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------MD--RTDRP
PQSGADYSFLVSQNTKLLSALEDLRHRCCSLAEENSLLRRSCFPQT-EEKVKHLKRKNAE
LAVIAKRLEERARKL-QEANLKVVTAPVPLK-------GSSLELCKKAFAHQRAKDLTEQ
ASALLAKDKQIEALQQECRELQAKL-L-------A--GKD----DPRCLNI-VEFDRLLR
ESQQEVLRLQRQIALKNFKECLRSSK--M---------SSGSAMPSA-AARLGPTSSC-L
K-------GA------S----RLKEALGDPALGGRAR--REEKQVMFLEVELKKKRKKCE
NLEHEVRKKHKRCKELEIQLQEVQNENARLAEENLQLNEKA--GWAGQVESENADLKLQV
V--LVTKERDSVIQTNQ--GLQTKLENLEQVLKHMRNVAERRQQLEVEHKEALLDLQ--E
KQEEVRRLQQAQAEAR-REHEGAVQLLES--TLDCMQARVKDLEDQCRSQTEQFSLLSQE
LQQFRLQTGKIDLL---TSTLVTSEL----PLALCSSA---PQPHWE---K-DEENDKLE
P----SQRGPDTTMGSP---------AA--PTSAQKQSKKGESQS--SSSK---------
-----------SESMQNSP-KSCPTPEVDTASEMEELDVDSISLMPE-------------
--PGSQGTAKLQVFLARYSYNPFD

PF07653 // ENSGT00390000017228_1_Domain_1 (1105, 1157)

GPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLMTFLPPELN--DLTHS-------------SYQEKSL
VSASTS--------SGDKSELSIE---------EGSISPLA--GRAEGDQEEPVSHTAVP
YPRRLTLIKQLARSIVVG---WEPPLLPAGCPDIQSYNIYVD---EELR-QNVKSGLQTK
A-VLEKLDLHS-RAY-RVSVQTVTERGR------------SDKLRCTFFVGQGFGVAPTM
LKVRSVTATSAEVTWLPCNSNYSHGVYLNGQECDVTKPGVYWYTFHNLQPSTQYVAKLEA
R-PMKTPWEEVPEGQEQDSAVIHFTTPLAGTPDAPLDVQVEAG-PSPDILVISWLPVTID
AEGSSNGVRVTGYAVYADGQKVIEVTS---PTAGSVLVDLSQLQMFQVCHEVSVRTMSQY
GESVDSVPAQISSVLL-PQHAPALLLPQK----SPA-E-SSDAKLADPSSSPAGSARP--
---L-----------AGKASSPPH--LPSPSARLA---PGTSP-----------------
--QGPGPVGDKKCLSV---PPQ--Q-----AGTALPGQG-TEPGPSQE-LGLP--QPAEG
T--EVQECPVKNTSEGQRVWG--LPEVVFWQGGEIESGRAEKQQEE--KLSEMGRRQLTL
FTEHNRSSDLSDILEEEEEDEL------------SSEALEEKKWDQ--RGPCSQENGEK-
---------MDLCDTDSDEEILERILELPLQKNHSKKLF-SIPEVTEDEDEDEDEGEH--
-------GAKESKV-DADHANPAF----G--QLACSQRKVHWNWCYQE------------
----NDQK---SGSGT------RPSW--SKKKGNNFQ----EKIRS----RPETSRKRQS
DLTEHCSRLLSNCSQM--GSGLYRAPSL-REELNVVSSASGKEGLDLYSRARQGTLR---
---------KKAPR-AVGSG---EAEPAVMA-THCPSPRSLEID------IEYDSED-DQ
DSTCASSPESRLWPERSQSCQGD---WSDCS--------------------MLS----KE
RT-PPLDSGGPEPPG--TAAWQA--PSRRRSKSIRRS------QMQKPLLS-SPGEMEAP
GNGWGEAGRQC----KG--R--TDVLSAVLPLCTGPPRSTA-PESSGKDDGIRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAAEEELPFKEGQILKVCGDKDADGFYRGECAGREGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VPVES
SEL----KQQLLKQGFLPADRDTESP--GNGTFSPPPRR-QTVPPPKPRRSKKGRRLWMA
GP----ALPCVLVPGPWRKHKDIEAELLTPR

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2615)

RMVAAFDYNPKESSPNTDVEAELTFSAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNQQRGLVPSNFLEAVPLDGDMAEEFHSKDKE-APLLSA
ESQRMRKR----RVQ---------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VLREREAEIRQLLRWKEAEMRQL
RQLLHRERDGVMRQARELQRQLAEELVNRGYCGRAGAP---------EVA-AAQCHCRLQ
EVLAQLRWETDGEQASRIRHLQAELDVERQLFLKYILEHFRWHPALPGSPNP---QAVPS
SEGPPPRAAND-SRG-PPKSV-CRLESLNADCLSAGVS--------LRSRSLDVVRA---
---GCSNSPDSLLH----T--RASSLDSLAPA-RSRSLDI-T-LSCPKA-PESEERAS-S
LGASILGSPSPPPPPPPPSPPSPPSPPPPQPPSEHRSPSDPP-G-DSGIQPCE-ALA--R
SPPGLDYQELVKQNSELSKALQALARRCSGLREENMQLRRAGFQDKSDEKVKRLKVKHAK
LTGLARRLEDRARKL-QETNLRAVSAPVPG------ESRAGLELC-QAFSRQRARDLSQQ
ESALLAKDKQIAELRQECHLLQARVATGFGSVLNPGGGAAQA--QAQRLNI-SELGRLQR
ESQREVLRLQRQLTRQQAT-GSAR--AEA-------------------------------
------------------------------DGQSAPSEEA-RRQLQALELELGARRRECE
ELGAQAATARRRGDEAEAQLQAALREGAWLAQENARLQAQA--DWTLKVAAENDDVRGQL
G--RACQERDAAGMLAE--QLLQQAA----------RGQDRQQQLQHDLQKALHDLQ--A
AREELLALQCQPGRPP-QEPQEAPQAPES---------QVRDSGRT------EFQLESED
QAPSQPSRDKWEN--------------------LEASQ------------RESPVAIEEP
ASAPQV--------------PDRVP--ASRPLESRSQAKKTSSQS--NSSS---------
---------E-VESMWATVPTSCPTVDMDTASEVEDLEPDNVSSTLEVGG----------
-SEA-PLAPKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLARYSYNPYKGPNEHPESELPLTAGDYVYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSDILDFLPLKSP----DLG-------------PT--RLP
AGQG--------------KCL-KE---------DTGHSFL--P-----------------
----------------------------------GKAQGAVD---RGPC-QMVGAGSETE
V-ATEISDAKT-EDSRLGALQCVKEKGF------------SRPLLG---TRGALCMAPMQ
LHLQNVAATSAKVAWVYSSSSHLHMVYLNGREHALTPAGVSCYTFHGLHPGTRYQARVE-
---VQLPWDSLQVHWETMSSTITFNTPLAGPPDPPLDVLVEH-HASPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVAEVAD---ATAGSTLLEFSQLQLPLMCQNVSVRTMSLC
GESLDSVPAQIPHNCLTC-HQLPETSSFSYP--------------------CSYPSTC--
----RVTIPVCS-------QG---A--------TS----------PQTPGSCGE------
----PQAKF--------LEAF--------------PEEPPRRQSPM-PNLSPKRECASAG
C------G-------------------------SQAQGPPEAQG----------------
------------------------------------------------------------
-------------------VCTKDLLLQQSSSNHRPPL-PSGQSRGED----RYW-H---
-------VAP---RQSPASGVI-H-RF---------------------------------
---PECGLNKEPYQE---------------------------------------------
--------KAVL------------EKVLRQTQ------------------------DTQA
LI-----------------------PSWLDTTSQP---YMSDFH------DI--------
-LQEEVVVCFSR--------------WGTKRREQRREFRTQNG------------R-GQ-
GLGGKRMCQLLEASP---------------------------------------------
-------------------ALCPAPSSKVIKM----PRGGPSPLGTGVDTLV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YDPLVMSASPEVAEEELAFQKGQLLRVWGSQNPCGFYHGECNGQVGSIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VKVDT
EQTD--GRWHLPVEGYLPPVAHFDDFGGLTN----P-----QGSFPMPQ-----------
-----------------GNPRMS--PLWTPT

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

TMMAALDYDPKDGRAGGQAKDKLSLRAGD
VVTVYGPVDDKGFYF---------------------------------------------
-------------------GESGGHRGLVPAHLLDRLSLHGK------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPPPGDP---GA---
----------------------------------------------MESWALPAWQSWTP
---GQGGEPGDTSPSIADTP-TALQVRELS--------------SQPQGAQSLGPVVGAD
PEGAEAGLPNLREQAGSSG-----------CGCP--RREDE---------EVQ--D---L
PKAMPNTSFGDRPNLELLRALEELQQRCATLKEENQMLRNSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GSQWLHV-RDFDRLLC
ESQREVLRLQRQIALRNQRELAG-----G---------CSQVPF----------------
--PA---PGHFQ----A----TPQEDVDSSPVVLGEP--EKQQRVQQLESELSKKRKKCE
TLEQEARKKQRRCEELELQLREAQNENARLVEENSRLTGRA--TEKEQVVWENVELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSTLGCSALGDHLPAPCCCST---PQPCRG---A-GPKDLDLP
PGSP-GHCSPKSSEPAP---------ATLTGVPRRP-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPT-A-----------
-TEGNLGGPRVQVYLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GQRG--LVPSNFV---ERVSDDDLLTSLPLELA--DLSRS-------------SGPELSF
LSGGGGGSSNGGQSSGGRSQPRPEEE---DAGDELSLSPA---------PEGLGEPPMVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GELR-QTLGPGAPPK
A-VLENLDLWA-GPF-HVSVQALTSKGS------------SDPLRCCLVVGAQAGVVPSQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPSARPSTYWTTFCNLRPGTLYQARVEA
QLPPQGAWKPGWEKPEQRSATLQFTTLPAGPPDAPLDVQIELG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQACREVTVRTMSPH
GESADSILAPVALAL-----TSARVTCPS-----PRPSPEARTPLAPV-----DPSSP--
---LQRSASHGT-------S-------ASPIRERP---KGGQE-EP--PAPRSQ------
-----------------VEAGATVSGASGERRVSETTVGEGDPGPSAPCRATQEAEWTAG
E-AGSAVCS---TQGALTQR---VPRAEACHGADPG--LRARAEREDTA--ELGVRLVNP
LVDHGRNSDLSDIQEEEEEEEEEDEEEEEEEEELGSRTSSFQKQVA---GNSIRENGPKP
---Q----PDPFCEIDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEED-------
NEGQE-KPGAGCSSQDPSPLEPALLG-LGCEGGQSP----GLGSYSLS------------
-PAPSRAR---DHLEDMPGL---VGGS-SWRRG-GS-----------PEKPPNRRRP--P
DPSEQCSRLLSNG-GPQASAR----PAPSRGRSGLPVIEGTRGGLEASGKGRPGTS----
-------------R-RCPRGRA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
DVGS-GGI-----SITSSCYPTDGEPWGMALAGRPRGP----------------------
---LKVNSDPSPYPH--LPAWEKGEPERRGRSATGRA------KEQPSRAV-DTGEARG-
QDSSGRKGPQR----RG--ARVPRPSTSEL----APLRSPP-ETLAHRDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGECGGQAGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLFQQGYLSPDVVLKDA--GNSPFVYSTAH-TAGPPPKPRRSKKAELEG--
-P----AQPFPGPPKL----I-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNPDVEAELPFRAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPRPEVGS------PDREPT-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VLREREAEIRQLLRWKEAEMRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCGRAGAP---------EVA-AAQCRCRLQ
EVLAQLRWETDGEQASRIRHLQEALDVERQLFLKYILEHFRWHPALSRPPDP---QAVQF
SEVPHPDTACN-SRR-LPKSA-CRLESLG--SLSAGVR--------VRSRSLDLVPT---
---ACSNSPGSLLP----T--RASSLDSLAPA-RSRSLDS-T-LSRPKA-PESEERASSS
PDTSILGSPSPPPPPPP--------PPPPPPPSEHRGPSDPP-REDSGSQPCE-ALT--L
SPLSLDYQELVKQNSELSQALQVLARRCSGLHAENMQLRRAGFPDKEDEKVKRLKVKHAE
LTGLARRLEDRARKL-QETNLRAVSAPVPG------ESRAGLELC-QAFARQRSRDLSEQ
ASALLAKDKQIEELQQECRLLQAHVASGLGSAPHPSGGAA----SAQWLNI-SDLDRLQR
ESQREVLRLQRQLTLQQAT-CRAR--AEA-------------------------------
------------------------------GGQSAPCEDA-RRQVQALERELGARRRECE
ELGAQAAEARRRGEEAEAQLQAALREGAWLAKENARLQAQA--DWMRKVAAENNDVRRQL
C--RACQERDATGLLAE--QLLQQAA----------RGQDKQQQLQHDLQKALSDLQ--A
AREEMRALQCQPGHPP-QEPWEAPPAPDS---------QGKNSRRT------RFQPEPED
QASSQPSRDKQEK---------------------ETSL------------LESPVALGDP
VSAPQV--------------PERVP--ASQPLDSSPQAKKTSSQS--NSSS---------
---------E-VESIWATVP-SCPALDMDTASEVEDLDPDSVSSTLEVGD----------
-SEA-PATLKLK

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

IFLVRYSYNPFEGPNEHPESELPLTAGDYVYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSDIFGCLPPESP----DLG-------------PT--QVP
AGQG--------------KAS-KE---------GTGHSLL--P-----------------
----------------------------------GKTQGAVD---RGTC-QK-KVGSKTE
V-AIEISDAKT-EDGWLGLLQSVEEQDF------------SRPLLG---AKGVLCVAPKQ
LHLQNVAATSAEITWVYSSSSHPHVVYLDDQEHALTPAGVSCYTFQNLHPSTRYQARVE-
---VQLPWDSLQTHWETMSSTITFDTPLAGPPDPPLDVLVEH-HTSPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVSEVTD---ATAGSTLLESSQLQLPLMCQKVSVRTMSLC
GESLDSVPAQIPQDCVTC-KRLPENSPFSYT--------------------CGDQFPC--
----RVTFPVCP-------QR---LALAPLIAKAS----------SHTPGSCGE------
----PRAEF--------LEAF--------------PEELPERHSPV-RNLSSEREYPSAK
A------G-------------------------SQGQGPTEAWE----------------
------------------------------------------------------------
-------------------VCRKEVLFQKSPQNYRLPL-PSSQSEEEED---HYQ-H---
-------RGT---SQSPALGVV-H-LS---------------------------------
---PKWGPGKELCQE---------------------------------------------
--------KATL------------EKDLRQKQ------------------------DAQV
FT-----------------------APQLGT-SQR---FVSDFR------NI--------
-LQKAEAVCFGP--------------WGTERQEQRRELRAQSG------------R-GQ-
ALGSKRECQLHEPSS---------------------------------------------
-------------------VLSPAPSNKVIKM----SRDGPPQLGVGVDTPVR

PF07653 // ENSGT00390000017228_1_Domain_3 (2334, 2396)

VFVALFD
YDPLVMSANPEVAEEELAFQKGQLLRVWGSLDPHGFYHGECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

AESGM
EQTD--RRRHLPAQGHTPSVAHLDDFRGLT------------------------------
--------------------RRP--PLWTPT

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

TMMAALDYDPKDRRGGGLVKGKLSLKAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHMSLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRSSPKKPGSPGPAAAVLEEQRRELEKLRAELETERARGRAERRRFATQ
ARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHQERDGVVRQARELQRQLAQELVNRGYCGRSGAS---------EAP-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALNSERQLFLKYILEHFRWQPALPEPADP---QAAHS
LEEPPLKAQSN-TYD-TPKPA-RRLGSL--ESLSTGVR----------------------
-----VSSPNELLP----A--RSSSLESLTRA-HSCPL------SCPRA-SESEVGGS-S
TSAPIPGTPSSHPPPQ----------LPS----IHRKTSELQ-EESSENKPCE-ALT--P
SPQGQDYHELVRQNSELAEALQVLVRRCCGLREENLQLRRSGFSDETDEKVKWLKVKHAE
LTGLAQRLEDRVRKL-LESNLLAVSAPVPG------ESLEGLNLG-QVFTRQCTQDLSEQ
AGALQAKDLQIEALRRECHLLQAYIATDFGSSPLPGEGAT----CAQWCSI-NDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AR--AEA-------------------------------
------------------------------GSLSSPSETA-QHQVQALERELGAQRRECK
ELSAQAAAAERRYEEAEAQLQAALHKGARLSEENAQLQALA--NWVKKIADENINVPQQQ
SHARQRQELEDTGLLAE--QLLQQAG----------CVQDRWQQLQYYQNKTPSDLQ--A
SGREMQDLQCQPDHPP-ET-LETTQASES---------QARGSRKP------KIKPKFEE
HALPLPTRDIQ-P-------------------PISLSQ------------Q-NSVTLEEP
AGIPQV--------------SDKNP--TSQPLDSRSQAKKTSSHS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSVSTPLETRS----------
-FEA-PTTPKLKIFLAKYSYSPLEGSNKHS

PF07653 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

QGQLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVSSNLV---EQISGSPTLNHLFPESP----EVG-------------PT--ALP
AEHS--------------KAL-------------KKDSLL--L-----------------
----------------------------------GEVQGAVE---RVLC-QVVRADSKTD
K-AVEVLETET-EGCWLGMKPSMEERSF------------SRPLLE---AKGVFCLAPMQ
LQLQNVTATSATITWASGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLCPGTRYRVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHH-ASPGFLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVMEVAD---PTAGNTLLEFSQLQVPLACQKVSVRTMSLY
GESLDSVPAQIPEDCFSC-SLFLETPPFSYT--------------------DGDP-----
-------SA-CR-------HS---PVSNLSSEGADNQ----VQGPTEARKDYED------
----PQDEF--------LEAF--------------SEEPPRKHSPV-SNLSSEG------
A------D-------------------------NQVQGPTEARK----------------
------------------------------------------------------------
-------------------DYEKGLSFQESPKNHKPLL-LFGKSGLEDG---HFP-H---
-------MCI---SGSPAPGFT-H-LS---------------------------------
---PETGPRKVPC-Q---------------------------------------------
--------KPGL------------EKALLQKQ------------------------YAQM
LP-----------------------PHQQGS-SQC---LATDWN------HVL-------
--EDTEAVCLDS--------------ECTEKLGQRKNTF-QSG------------Q-RQE
T-----------------------------------------------------------
----------------------PMPTNKVIKM----ASGGPE---TEANGPVRVFVALFD
HSPPVMSVNSK

PF07653 // ENSGT00390000017228_1_Domain_3 (2352, 2395)

DSEEELVFRKGQLLRVWGSRDPHGFYHGECNGQVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2495)

EVEVGT
RQTN--ERWLLPAQGHLRSETQHEDLEGLTN----F-----QGSF-MPQ-----------
-----------------GTPRIP--TLWTPKTMV

PF07653 // ENSGT00390000017228_1_Domain_5 (2495, 2612)

AALDYNPRDGRAGVRAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVYGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------MKLLSALEDLRHRCSSLTEENSLLRRSCFPET-EEKVKHLKRKNAE
LAVIAKRLEERARKL-QEANLKVVTA--PVP-----LKGSSLELCKKAFARQRAKDLTEQ
ASALLAKDKQIEALQQECRELQAKL-----IA-----GKG----DPRCLNV-VEFDRLLR
ESQKEVLRLQRQIALKNFKECLRPSKGSSGGSLPSAASCPGPALNACSKDSPAAK-EVCS
GGPALGGAAHGKVEPGVLPLGPALEGHENFPPKNAVADQESSQQIQQLEFELKKKRKKCE
NLEHEVRKKHKRCKELEIQLQEVQSENARLAEENLQLNEKA--GWAGQVESENADLKLQV
V--LVTKERDSVIQRNQ--GLQTKLENLEQVLKHMRDVAERRQLLEAEHKEALLVLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLEA---------RVKDLEDQCRSQTEQFSLLSQE
LKQFRLQTGKIDLL---TSTLVTSEL----PLALCSSTPQP---HWE-KDSPGP-ALLAH
QSIKKVHNEETNESESSQRVPEAAVGSPVSTASSQKQAKKAESQS--SSS----------
---------K-SESMQNSS-KSCPTPEVDTASEMEELDVDSISLM--------------P
DPGS-QGPAKLQVFLARYSYNPFDGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLVTVLPSELN--DLTHS-------------SYQEKSF
VSASTS--------SGDKSDFSIE---------ESSISPL--VSRAEGDQEERVSHTAVP
YPRKLTLIKQLARSIVVG---WEPPLMPAGCPDIQSYNIYVD---EELR-QNVKSGFQTK
A-VIEKLDLKT-KAY-RVSVQSVTEKGS------------SDKLRCTFYVGQDLCVAPTM
LKVRNVTATSAEVTWLPCNSNYNHAVYLNGEECDITKPGVYWYTFCNLQPNTQYVAKLEA
R-PLKTLWEEVSEGQEQNSAVIHFTTPLAGTPDAPLDVQVEVG-PSPGILVISWLPVTID
AEGSSNGVRVTGYAVYADGQKAIEVTS---PTAGSVLVDLSQLQMFQVCREVSVRTMSLY
GESVDSVPAQISSVLLRASHRSS--PSDSAV----------STTLTSRLP-CGESRGSLP
A---RSPPTHQT-------AA---LLLRQ----------------------KVPTDSSDA
KLT--------------DLSSS--HDGSA---QSLPEK------------ASLVLQLSPS
S------AS-------L---------VHTSGTSLQGSD--TAQ----------DKKCLTV
SPQQASST---KLLGEGTEPVS-S--REAELKSLGEGT---EVLMEQ--------NVNKM
--------PELESPTNA-----SLMIRMETCHTCTVEESPKSPSAERETEAKEKNLS---
-------PEP---LPSPS-Q----AEE---------------------------------
----M---------------------------EGTS---------------RD-----AS
VGGSSCQEFLRLS--P--------SKEVMKE-------------MSRVK-------REQE
EKMSEI----GRR--QLTLFT-------E----HN---RSSDLSD------ILEEEE-ED
ELSS-ETLDEKK--------------WDPREPCYRENGE-------------------K-
ASGNKD-PRGQELPG--SAAWQT--PSRRGNRSLQRSQ----------------------
----------MQKPS----LSSPGP------------PRSSASETTVEDDGIRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAAEEELPFKEGQILKVCGDKDADGFYRGECAGREGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VQVEN
NEI----KMQLLKQGFLPADPPTESIAELDKQEKYK-----S--HPGQK-----------
-----------------HQDFEA--ELLTPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAVFDYNPKESSPNADAEAELTFSAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNQQRGLVPSNFLEAVTSDGDVVEELHSKDKDTF-LLSA
ESQRMRKR----RVQ---------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSILRPGDP---AA---
----------------------------------------------MELWALPAWQSWTL
---GQGGEPGDVAPSIADTP-TALPVKDVRSE------ESSE----PEGAQSPRLLGGSD
PEGTESG-----QQEVSSG-----------HHGQ--RLEDE---------EVG--A---L
PKAKLNMGFRDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVNAPLPRP-------GASLQLCQKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPP---PPAR---------PPGSTAPAR-AGA---------
--PA--PGAPGE----A----TLQEDVDSPPGILGEP--EKQQKVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGSA--TQKEQVEWENAELRDRL
L--GLTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPSCCCST---PQPCRG---S-GPKDLDLP
PGSL-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLVPA-A-----------
-PEGNPGGSRIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPSELA--DLSHS-------------SGPELSF
LSGGGGGSHSGGQSSGGHSQPRLEEE---DAGDALSLSPP---------PEGLGESPAVP
YPRRLVVLKQLAHSVILA---WELPP---ERVDLQGFHICVN---GEPR-QVLGPGAPPK
A-VLENLDLRA-GPL-RVSVQALTSKGS------------SDPLRCCLTVGARAGVAPSQ
LQIHRLTATSAEITWVPSNSNLAHAIYLNGEECPPARPNTYWATFCHLRPGTLYQARVEA
QLPSRGSWDPGLEKPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELFQLQLLQVCREVTVRTMSPH
GESADSIPAPVA-----PACLPARLSCPS----SPRPSPEVRTPLAPASPEPGDLSSP--
---LQHPVPHGT-------QEPPGGPPASPSRHEP---RGPQEEP----PSCSQ------
-----------------EASVTALLGSSEEKKANEPTLAEGGPSTVA--------ERASR
E-TVPTPCS---TQGALAQR---VPSTEVCHGGAPESGLRPGAESEDASVEGPGPHLVNS
MVDHGRNSDLSDIQEEEEEE-------EEEEEELGSRTCSFQKQIA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEE-----------
-EDEE-KPGAGCSSQA---PEPVLLG-LDRDSDQLQ----GPGPCPLS------------
-PEPSRAR---EHLEDMFGL---VGGN-SRRRGSGS-----------PEKPPSRKRP--P
DPREQCSRLLSNG-GPQASARPGAGPGPPRERGSLPVVEGTRGGLEAGGRGRPGLS----
-------------R-RCPRGPA----LEAGL-ASCLSPKCLEIS------IEYDSED-EQ
DLGI-GGI-----SITSSCYPTDGEIWGTATVGRPRGP----------------------
---LKVNSGPNPYPR--LPAWEKGEQERRGRSTTGRA------KESPSRAT-ETGEPRG-
QDSSGRRGPQR----KG--ARMARPVITEL----APPRSPP-EALAHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2496)

VAVDS
LAG----RQQLLQRGYLSTDVLIEGS--GNGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCQAAPKL----I-PSACLKAPRPMVA

PF14604 // ENSGT00390000017228_1_Domain_5 (2496, 2615)

AFDYNPRESSPNMDVEAELPFRAGD
VITVFGNMDDDGFFY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGR------PDRDPG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VQREREAEIRQLLRWKDAEMRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCGRPGAP---------EVG-AAQCRCRLQ
EVLAQLRWETDGEQAVRIRHLEAALDSERQLFLKYILEHFRWRPALSDPSQK--EQ----
---PPEAT----GCR-RPEP-TCRQR-----PLRRGTH--------VRSHSLVLVPT---
---ARCGSSDGALP----P--RASSLDSLAPA-QLCWLDG-T-QSRPKG-SEPEEQISSL
PDASVPSDPSHLXXXXXXXXXXXXX---------XXXXXXXX-XXXXXXXXXX-XXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXAVSAPVPG------ESSAALELC-QAFERQCTRGLAEK
ESALQAKDKQIEELRQECHQLQARFVSILRSAPLPGGGAP------------GELDGLLR
ESQREVLRLQRQLTVQQGQ-GGAR--TEV-------------------------------
------------------------------GCQSAPCEDG-WRQVQKLERELGALQRKCE
ELGAQVAAAQRKSDEAEAQLQAALREGAWLAKENARLQAQA--YWVRKVKDDNSDVPRQL
G--SACQEREAAGLLAE--QLLQQAA----------HWQDSQQQLQHYPQNALWHQQ--A
AREEIRALKCGLQ--------EATHFPKC---------QAMGSRRP------QFQPGLQD
QALSQPSTDRLTR---------------------DTSL------------PERQVALGET
GPW------------------------------TLPQDKRT--SS--NSSS---------
---------E-MESVQATVP-SCPNPVFDTASEVDDLESDNVSLNLDMGG----------
-IEV-PATTKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLAHYNDNPFEGPNEHPERELPLTAGDYLCISGNTNEDGFYKAELED
SRQG--LVRSAVV---EQVLDSDISDCLPSKSP----NPD-------------PI--PLP
TRLV--------------KAS--L---------DTSLSLL--P-----------------
----------------------------------GKTQAAGD---RGSR-SVVKVSSKTE
V-PMEISDAEI-EVCQLSSLQSGGEQGV------------SRALPG---ASESFSVAPTK
PELKSVTATSAEISWVCSTNSHPHVVYLNDQEHTLTPAGVNCYTFQSLRPATRYQASVE-
---ARLPWDLLQVHWETMSSTITFTTPLAGPPHPPLDVLVER-HSSPGLLVVSWLPVTID
SAGSSNGVQVTGYAIYADGLKVAEVTD---ATAGNTVLDFSQLQVPVMCHKVSVRTMSLC
GESLDSVPAQIPEDCFSR-YPFLETSSFDYT--------------------LGDPAAC--
----RVAFPDYP-------EK---PELALLSAKAS----------SYTPGSFKE------
----LQAEF--------LGIF--------------PEEPLRRWSLV-PTLRSKGECPSLG
A------G-------------------------NQVQRPREAWE----------------
------------------------------------------------------------
-------------------ICGKDPLFQESVQDHRQPL-PGSHSAREEN---HYP-D---
-------VET---SKSPTPGLV-H-PF---------------------------------
---PKCRSMKVSCHH---------------------------------------------
--------QSSL------------EKTVRSKQ------------------------DAQA
SN-----------------------SAQQGP-CQQ---YACECC------EMS-------
--PEEEEPHFHA--------------WSVEQQGQKEALRAQSG------------R-GQ-
ALEDKQECHVHEPTS---------------------------------------------
-------------------LLCPGVSSKVIKM--Y-SRDGPTRLGQESDAPARVFVALFD
YDPMAMSANPQSAEEEL-------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAATVFENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFCRNPALSEPPDP---QAVHS
LEERLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEVRSS-S
PNTSIPGSQSLPPPPSPLRPPPP--------PSVHRKLSNPQGEEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCAGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGQV
G--RACQERDAAGLMAE--QLLQQAA----------RGQDRQQQLQCDPQKALCDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SVA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLC-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTTTFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------AHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RTWCLPAQGHLPSVTHLEDFQGLAI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKAMIAALDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVHGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRAELEAERARGRAERRRFGAQ
ARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHQERDVVVRQARELQRQLAQELVNRGYCGRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDSERQLFLKYILEHFRWQPALSEPADP---QVVHS
LDEPPIGAQSN-TGG-TQKPA-RRLGSL--ESLRTGAR----------------------
-----VSSPDDLLP----T--RASSLESLATA-HPCSLDS-T-RSCPRA-PESELGAS-S
TSASRPGTSSPPPPPQ----------LPS----KHKKPSDLK-GESSENKPCE-APT--L
SPPGQDYHELVKQNSELAEALQVLVRRCCDLREENLQLRCTGFSNETDEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLQAVSAPVPG------ESLESLDLG-QVFAHQRTQDPSEQ
ADALQAKDLQIEALRRECHLLQAHIAADLGSSSLPGEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AR--AEA-------------------------------
------------------------------GSLSSPSEIA-RYEVQALEEKLGAQRRECE
ELSAQAAAAERRYEEAEAQLQAALHKGARLSEENARLQALA--SWVKKMADENSNVPRQQ
NHARQRQELEATSLLAE--QLLQQAG----------YVQDGWQQLQYYQNKAPSDLL--A
SGKEIQGLQCQPGHPL-ET-SETTQASES---------QARDSRRP------KFKPKSEE
HALSLPTRDIE-P-------------------PVCLSQ------------QENSVTLGEP
AGIPQV--------------SEKNS--ISQPLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSVSSPLEMRS----------
-SEA-PTTPKLRIFLAR

PF07653 // ENSGT00390000017228_1_Domain_1 (1098, 1157)

CSYNPFEGSKEHSQGQLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSNLV---EQISGSPILNHLLPKSP----DIC-------------PT--ALP
PEQT--------------KAL-------------KKGSLS--L-----------------
----------------------------------GEFKGSLE---TGLC-QVRRTDSKTD
V-AIEILETKT-EACWLGLKPSMEEQSV------------SRPLLE---AKGVFCLAPMQ
LQLQNVTATSATITWASGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLHPGTRYRVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHH-ASPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLRVPLACQKVSVRTMSLY
GESLDSVPAQIPEDCFSC-YPFLDTFPFSYM--------------------DGDP-----
-------LT-CR-------V-------ISLSTKTS----------PHTPGSCGE------
----PQVKF--------VEAF--------------PKDPTRKHSPI-SNLISER------
A------D-------------------------NQVQGPAETWK----------------
------------------------------------------------------------
-------------------DYEKGLSLQESPQNLKPPL-PFGQSGVEEG---HSP-H---
-------MCI---NGCPAPGFI-H-LS---------------------------------
---PEIGPRKVLRWE---------------------------------------------
--------KPGL------------EKA-LQKQ------------------------YDQT
LP-----------------------PHQQGS-SQL---PTADFH------HVR-------
--EEKAAVCLDS--------------RCTEKLGQRKNKF-QSG------------Q-TQE
TPGGKRE-----------------------------------------------------
-------------------LLCPVPTSKVIKM----ASGVPEKPETEANNPVRLFVALFD
HSPLVMPVNAK

PF07653 // ENSGT00390000017228_1_Domain_3 (2352, 2395)

SPEEELVFQKGQLLRVWGSQDPHGFYHGECNGRVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2512)

EVEVGT
DQTD--KRQPLPAQGHLHSEAQHEDLEGLTN----S-----QGSL-MSQ-----------
-----------------GNSRTP--TLWTPKTMVAALDYDPRDGRVGVRAK

PF07653 // ENSGT00390000017228_1_Domain_5 (2512, 2612)

GKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSLPRPGDL---GA---
----------------------------------------------MEPWALPVWQSWIP
---GQGGEPGSTAPSVADTP-ATLQVGKSRPG------ESSE----PEGAQSPGPVEGTE
SEGTLAGLPIPRQHAESSG-----------PSCP-PKLEDE---------EVE--A---S
SKAKLNTGFGDRPNLELLRALGELQHRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLESCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPPVASTCGNFDRA--
-SLREVPSG-RVLPATEGRSPL---RKPI---------SGGPTQPSR-------------
AQPA--PSPPAG----A----VAREDANNPQVVVGDP--EKPQRVQQLESELSKKRKKCQ
SLEQEARKKQRRCEELELQLREAQNENARLVEENSQLSGRA--TEKEQVEWENAELRGQL
L--GVTEERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSAPGDRLPPPCCCST---CQPCRG---S-DSKDLDLP
PGSP-GHCTPKSSEPAS---------ATLAGTPRRT-AKKAESLS--DSSR---------
-----------SETIHNSP-KSCPTPEVDTASEVEELEADSVSLFPA-A-----------
-PEGTRGGSRI

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTTLPPELA--DLSQS-------------SGPELSF
LSGGGGGSSSGGQSSGGHSQPRPEEE---DAGDELSPSPS---------PDGLGEPPAVP
YPRRLVVLKQLAHSMVLA---WEPPP---ERVELHAYHICVN---GELR-QALGPGAPLK
A-VLENLDLQA-GLL-HVSVRALTSQGS------------SDPLRCCLAVGARAGVGPSQ
LQVHRLTATSAEITWVPSNSNL-HAIYLNGEECPPARPSTYWATFCNLRPGTPYQARVEA
QLPPRGSWEPGWERMEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
VAGSSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLRVCQEVAVRTMSTH
GESADSIPAPIAPALA-LACLPAGVPCPS-----PRPGSEARPPLAPASPGPGDPSSP--
---LRHSVPDGT-------QEPPGAPPASPSREAS---KGSQE-EP--PESCFQ------
-----------------EEAGVAVLSTLEERRVSEPTVGERDPGPAAPELAQEEAEWRTG
E-AHPLSCS---TQRALAQW---APCTEASR-GDTGSGLPARAEREDPA--ELGARPVNS
LVDHGRSSDLSDI-------------------TLGSRPCSFQKQVA---GNSIRENGAKP
PP-L----PDSSCETDSDEEILEQILELPLQHFCSKKLF-SIP-----------------
--------GAGHFSQDPSLSEPVLLG-PGCDSSWPR----GPGPCPLS------------
-PELSRTG---DCLEDVPGL---VGGS-SRRRGGGA-----------PEKPPSHRRP--P
DPREHCSRLLGNG-GPQPSGR----PGPTRERGSPPVSEGTRAGPEAGGRGRPPPS----
-------------R-RCSRGRA----PESGL-ASCLAPKCLEIS------IEYDSED-EQ
EADS-GGI-----SITSSCYPGEGEAWRAASIGRPRGP----------------------
---LKANLVSTPYLR--LPAWEKGEPERRGRNATGRA------KEPPSRAT-EMEEPRG-
QDSSGQRGPPK----RG--ARASRPVSSEL----APPRSPPEEVLAYQDLPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RIFVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRMGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVDS
HSG----RQQLLEQSYLSPDVLVEGSEHSDAPHVFQVLE-QLGLPPKPRRCQEKLAELEG
-P----AQPCTGPPKP----V-SSAGLKAP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RLMVAAFDYNPRENSPNMDVEAELPFQAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEARN------LDREPG-TAPA
ESQRRRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGGEPGDRAPSIADTP-TALQVGELRPE------ESCE----PEGAQSPRPMGGID
PEGAEAGLPSLGQQAVISG-----------RGCL--RLKDE---------DVE--A---L
TKAKVNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVPGP-------GASLEFCRKALARQRARDLSDT
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPP---PPPR---------PPGSTAPAR-AGAP--------
---A--PGAPGE----A----TPQEDVESPPVVLGEP--EKQPRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--SEKEQVEWENVELRGQL
L--GVTQERDSALQKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTQKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSQLPA-A-----------
-PEGNPGTARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPRPE-E---DAGDELSLSPP---------PEGLGEPPAVP
YPRHLVVLKQLAHSVVLA---WELPP---ERVELRGFHISVN---GELR-QALGPGAPPK
A-VLENLDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLALGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPSARPSTYWATFCHLRPGTLYQARVEA
QLPSRGSWEPGWEKPDQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCHKVVVRTMSPH
GESADSIPAPIAPALT-PACLPARVSCPS-----PRPSPEARTPLAPASPGPGDPSSP--
---LWCPAPHGT-------QDPPGGPPASPSREMP---KGPQE-EP--PAPCSQ------
-----------------EEAGAAVLCASEEKRASEPTLGEGGPGPVAFSLAEQEAEWTAG
E-ASSTAYS---TQATPAER---MPNTETCCGGDPGPGLRPRAEKEDMA--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE--------EEEDLELGSRTCSFQKQVA---GNNTRENGAKS
---Q----PDLFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEE----------D
EDDEG-KPGAGCPSQDPGPPEPALLG-LGCDRGQPQ----GPGLCPLS------------
-PEPSRAR---DYLEDQSGL---VSGS-CRRRGGSS-----------PEKPLNRRRP--P
DPREHCSRLLSNGGGPQASAR----PGLPRDRSVLPVIEGTRSGVEAGGRGRLGPS----
-------------R-RCHRGRA----PESGL-SSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPADGEAWGTAPIARPRGP----------------------
---LKVNSGPHPSPR--LPAWEKGEPERRGRSATGRA------KEPSSRTT-EAGEPRG-
QDCSGRRGPQK----RG--ARVPRPGATDL----APPRGPP-EAL---DLPVRL

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGECGGRMGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_4 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDVVLEGS--GNGPFVYSTAR-TPGPPPKPRRSKKADSEG--
-P----VQSCPGPSKL----I-PSADLKAPRP

PF07653 // ENSGT00390000017228_1_Domain_4 (2493, 2542)

MVAAFDYDPRENSPNMDVEAELPFRAGD
VITVFGSMDDDGFYYVRTLWGRAHRAPTLGQGDGQGSWRNGPGASLDSDVGSRLFSRGLR
IKEARLVFPVSVSPASPPQGELNGQRGLVPSNFLEGPGPEAGS------PDKEPG-IPQA
ESQRMRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERWRFAAR
ERQLREEAERERRQLADHLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLQRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVGRQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVG--------VRSRSPDLVSS---
---ACSSSPDGLLS----T--HASSLDCFAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPRGGEGSESQPCE-VLT--P
SPPGLGHQELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGL----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLMLQQGN-GFSRPPPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASGLIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH--A
SWKEIQALQCQPGHPP-EQPWETSQMPES---------QVKGSRRP------KFQARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEMGD----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNFV---EQIPDSYIPGCLPAKCP----DLG-------------PN--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGVVD---RGLC-QMVRVGSKTE
V-ATEILDTNM-EACQLGLLQSMGKQGL------------SRPLLG---TKGVLRMAPMQ
LHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVE-
---VRLPWDLLQVYWGTMSSTMTFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPDDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPS-VSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEACQE---------------------------------------------
--------KAAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILKE-----
---EQEALCLDL--------------WGTERREERREPEPHSR------------Q-GQ-
ALGVKRECQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSLAQGHPPSVAHLEDFQGLTN----P-----QGSCLVLQ-----------
-----------------GNSKRL--PLWTSKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGTGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------LTA--QLQEQAA----------QSEASRQQLQQELQEALSAQP--G
--RERQRMQQDQEQMR-GSTRQLCG--SG---------PSRELEMPCT------------
-------------------------------------------------PQEGAAHAAAP
GE-----------------------------------VKKVSTQA--SAL-E--------
-----------LASGQLNF-PSFPAPEVDTGSEEEEEEADSLSPAPEPE-----------
GPAT-TAAPNL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLARYDYDPFAGPNDQPEAELPLTAGEYIYIFGDMDEDGFYAGELMD
GQRG--LVPSNLV---EQISDSEILNCLDSKPLVVGCCQR-------------PEGQEEA
LEEA--------------------------------------------------------
---------------------------PFAPNSYGATHGMVD---NELW-ENVGAGSQTR
V-TIDNLDLTT-RAY-RISVQSVTDRGC------------SNRLQCSFLVGGGLP-RPSQ
LLLRTLTSTSAEISWLDSSSNCPHVVYLNEQEHRLTKAGVCYCTFHNLQPGTSYCARVET
R-PREDL-----QCWGKMSSSITFTTPSAGPPDPPLDVLVEYH-TSPGTLIVSWIPVTID
SAGSSNGVAVTGYAVYVGGQKVIEVPS---PTAGNVLVEFSQLQ----LQEVSVRTMSHY
GESLDSVPAQIPGEWLKRFSAYRPPQVFPVI----------HSS--------GDPF----
--PDRPSVPVSQ-------DK---SILGSFS---------T-KTSTPIPASCWIKC-PSD
E---FP------------------------------E---DGFQM----PNSEGELLSPG
D-----------------------------INAPQGPGQAYASRK------------KGL
F-----------------------------PRRLGNPRHLSEGQI---------------
-------RVEEECKGCAKMAPGSGLLDIPLENGLLKEIYTENYSGGK---VPRNRLE---
-------ARP---V-SPQ------------------------------------------
------------------------------------------------------------
---GLCLHPSDL---------------------------------------ASVEEEDQY
VNMWGT------------------------------------------------------
-----------------------------RRPRQKKEFRLKR---------------PD-
PAGLKKVG-PLAETS--AMLYQA--PSGKMTKVLKASP----------------------
-----------------PWFR---------A------VT---------DNPF

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALWD
YDPWLMSTNPAAAEEELAFQQGQLLKVWGDQDPDGFYHGECSGRVGYIPGDMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VQVRQ
D-M----L-KQAPQGHLPSGVSLDAVLGLSTQLPNP-----QQSFSMAR-----------
-----------------GVSLPA--QLWHP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

QTMVAAFDYHP------------LTLNAGD
VVTVLGSVDGNGFFY---------------------------------------------
-------------------GELNGQRGLVPLNLLKTPTLNAE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------TLQRST-SRAR--AGD-------------------------------
------------------------------SGQSAPSEEAARSQIEALERELGALRRECA
DLSAQAAAERLRGEEAEAQLRAAQHKGAWLARENARLQTQA--EWMSRVAEENRDVREQL
D--RACQERDAAELLAQ--QLLQQAT----------REQDRQQQLQGDLQKALRDLQ--A
AREEMQALQHQPALQS-GDPQEIPQGLAS---------QGKKNGST------EFLPGLGD
PASLGPGRNRQKK---------------------DPSQ------------MENPVALGEP
ASVPPM--------------PNRVP--ANRPPDSRPQTKKLSSVF--NVSS---------
---------E-VESAWTSVP-S--FLDVDMANEVDGLELDNVSSTLKTEK----------
-SEA-SDTPKFK

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

IFLARYSYNPLEGPNEHPESELAFTAGDYVYIFGDTDEDGFYEGELED
GRRG--LVPSNLV---EQITDGDVLGDLPSGPH-------------------------LP
IGQG--------------KA-WKE---------DPDHSSF--L-----------------
----------------------------------GEPQLLDGPEVREPE-ELVKAGSEIE
V---ALLGAKA-ATDHLDFVHEMEEQGF------------FRPLLG---APASLCLGPMQ
LHLQNLAATSAEITWVYSSSSHPHIVYLNDQEYSLIPAGVSHCTFHHLHPGMRYQVRVE-
---VQPLWDSLQGPSESLSFTITFTTPLAGPPDPPLDVLVEPXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------XXXXXXX--
----XXXXXXXX-------XX---XXXXXXXXXXXX-----X---XXXXXXXXX------
----XXXXX--------XXXX--------------XXXXXXXXXXX-XXXXXXXXXXXXX
X------X-------------------------XXXXXXXXXXX----------------
------------------------------------------------------------
-------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXX---XXX-X---
-------XXX---XXXXXXXXX-X-XX---------------------------------
---XXXXXXXXXXXX---------------------------------------------
--------XXXX------------XXXXXXXX------------------------XXXX
XX-----------------------XXXXXX-XXX---XXXXXX------XXXXX-----
--XXXXXXXXXX--------------XXXXXXXXXXXXXXXXX------------X-XX-
XXXXXXXXX-XXXXX---------------------------------------------
-------------------XXXXXXXXXXXXX--X-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXVTPKGERKEVAFQKGQLK--VGSQIPHSLYYVKCSEQMGNIPGHLQNEEEIQE
RLV---SQWLLPSSRHQPSMTTLDDFELLPS----S-----QGSFHLPP-----------
-----------------GDPRKS--PLWTPK

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

TMMAALDYDPKDGSTRGQWKGKLSLRAGD
MVTVYGPVDDDGFYY---------------------------------------------
-------------------GESGSRKGLVPAYLLDHVSLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPPPGDP---RA---
----------------------------------------------VEPWPLPSWQSWTP
---GQGGEPGVAAPSIAATP-AARQLGKLRPE------ESPK----AEGARSPGAMAGTD
PEGTEAGLLSQGQQAASPG-----------PGHL--KLQDK---------EVE--A---F
PKATPNVGFGDRPNVELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-HETNLRVVSAPLPHP-------GASLDLCHKALARQRARDLSET
ASALLAKDMQIASLQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQGPP---PPPR---------PPGPAVPVTRAGAPAPGAPGEV
PAPA--PG-HFQ----A----ASQQDVDNPAVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLAEENSRLHGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVQRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCGALGDQPPPPCCCST---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLIGIPRRS-AKKAESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGGRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGAGGGSSSGGQSSGGRSQPRPEEEEKEAAAEELSGSPQ---------PEGLGEPPAVP
YPRRLEVLKQLAHSVVLA---WEPPP---ERVELHGFRICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSRGG------------SDPLRCCLALGAGAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPPRGSWEPGWEKPELRAASLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCHQVTVRTMSPH
GESADSIPAPVASALS-PACLLARVSCPS-----PRPSPEARPPPAPASPGLGDPSSP--
---LRCPAPHGT-------QDPPGGPPTSPGRETP---RGPRE-EP--LAPCSQ------
-----------------GEAGGAALGTAE-RGTGEPSLAEGGPGPAAPSLAKQEAEWTAR
E-ACLAPCS---RQGALVQR---TPGTEACCGGDAGSALRTRAEREDTA--ELGGRLVNP
LVDHGRNSDLSDIQEEEEE--------EEEEEELGSRTRSFQKQVA---GDSTRESGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKELF-SIPEEEEEEEEED-------
-EEEE-QRRAGHSSRAPGPPEPALLG-LGCDGGQPQ----GPGLCSLA------------
-AEPSRGG---DRLEDVPGV---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSSS-GPQCPGR----PGPTRERGGSSVVEGTKVGLEAGGRGRLAPS----
-------------R-RCPRGRA----PESGL-ASCLSPKCLEIS------IEYDSDD-EQ
EAGS-GGV-----SISSSCYPGDGEAWATVPGARPRGP----------------------
---VKASPGPSPSSR--LPAWEKGELERRGHSTTGRA------KEPPSRAT-EPGEPRM-
QDSSGRRGFQR----RG--ARGPRPGATEL----APLRSPP-ETLASQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQVLKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
AAG----KQQLLQQGYLAAETLPEAS--GNGPFVYSTAR-IAGPPPKPRRAKKAEADN--
-P----VQPGPGPPQP----V-PSACLKSAHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------PDREPG-MSQA
EIQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAAR
ERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVG--------VRSRSLGLVSS---
---ACSSSPDGLLS----T--HASSLDCFAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPRGGEGSESQPCE-VLT--P
SPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLMLQQGN-GGA--WPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASGLIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH--P
SWKEIQALQCRPGHPP-EQPWETSQMPES---------QVKGSRRP------KFHARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SSPTLDRDTASEVDDLEPDSVSLALEMGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PS--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGVVD---RGLC-QMVRVGSKTE
V-ATEILDTKT-EACQLGLLQSMGKQGL------------SRPLLG---TKGVLRMAPMQ
LHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVE-
---VRLPRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LSLAPPSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPS-VSDQPGEKEN---CSQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KAAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NVLKE-----
---EQEALCLDL--------------WGTERREERREPEPHSR------------Q-GQ-
ALGVKRGCQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSPAQGNLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------FELP-------------
--SLGQGLLKLR

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

RFLARFSYNPFEGPNEHPEAELPLTAGEYVYVLGDMDEDGWFVGELTD
GKRG--FIPSNFV---EEVSDDEPVTNVPPELR--DL-----------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPPPGDP---GA---
----------------------------------------------LEPWTLSAWQSWAS
---GQGGEAGIIAPSIAATP-AALQAGAQRPE------ESST----LERACNPGAEVGMG
LEGTXXXXXXXXXXXXXXX-----------XXXX-XXXXXX---------XXX-------
-XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXX----------XXXXXXXXXXXXXX---XXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-------X--XXX----XXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX------X---------XXXXXXXXX-------------
---X--XX-XXX----X----XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---X--XXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXX---XX-XXXXXXXXXXX-X-XXXXXXXXXXXXXXXXX-XXXXXXXXXXX
XXXXXXX---XXXX---XXXXXXXXXXXXXXXXXXXXX---XXXXXX---XXXXXXLDLP
PGSP-GRCTPKSSEPTP---------AMLTGISRRT-AKKTESFS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-V-----------
-PEGSRGGARI

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFIARYSYNPFEGPNENPEAELPLTAGEYIYVYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGSGCRSEAQNSGGQSQPRYEQQ--ENTTEELGVSPS---------PEGLGDPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRHLVVLKQLARSVVLA---WEPPP---ERVQLLGFRICVN---GELR-QALGPGATPK
A-VLENLDLQA-EPL-HVSVQALTSRGG------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLTHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPTQGPWDPGWERLEQRAAALQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVMGYAVYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCRQVTVRTMSPH
GESADSIPAPIAPALS-PACLPARASCPS-----PRPSPEARSPLAPASPGLGDPGPP--
---LQRLAPLGT-------QDPPGGPPASPGRELP---RGPQE-ET--LARCSQ------
-----------------EEAGEAAVGTTDKRRASEPALAEGGCAPAAPSLAKQEVEWTAR
E-ACLASCS---IQGAMIQR---PPGSEACCGGDTGSGLGSRAEKEDTT--GLGGCLVNS
LVDHGRNSDLSDIQEEEE----------EEEEDLASRACSIQKQVA---GQSSREIRAKP
---Q----LDAFCEADSDEEILEQILELPFQQFCSKELF-SIPEEEEEEEEE--------
--EEQ-LQGASPSSRAPGLLEPALLG-L--DSGQLQ----GPSPGPLS------------
-LEPSRAG---DRLEDGPGV---IGGN-GRRRGGGS-----------PEKPPNRRRP--P
DPREHCSRLLSNG-PSQASGR----PGPMRDRGSPSVAEGSKTGLEAGGRGRLGLS----
-------------R-RCSRGRP----PESSL-ASCLSSKCLEIS------IEYDSED-EQ
EAGS-GGL-----SISGSCYPGDGEAWATAPVARPRGS----------------------
---LKASLGPSPSPR--LPAWEKGEPERRGRSTTGRE------NMSPRGAV-EPGELRG-
QDSSGRRVLQR----RG--ARVPRPGVNEL----APPRSPS-KAPAHQDLPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RLFVALFD
YDPVSMSPNPDAGEEELPFQEGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VAVDS
AMG----KQQLLRQGYLSPEALAEAS--GNGPFVYSTAH-TAGPPPKPRRAKKAETDN--
-S----AQPGPGPPQP----IISSACLKSAP

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2616)

SMVAAFDYNPRENSPNMDVEAELPFRAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEDPGPEAGG------PDRQPS-APQT
EVQDWVST----TP--------------GSSRPPGWACVPGPGSPMKIK-----------
-------------------PGQPQGTNKMVRSLLSKGKQLLRSLGSGKKE----------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSLPSLGDP---GN---
----------------------------------------------MEPWALPAWQSWTP
---DRGGDAGGASPSMAGTP-TDLRVGELRPE------ESSE----PEGARSLGPVGGTE
PGRTGTGLLSPAQGALSSG-----------PGCQ--RLEDL---------EAE--A---F
SKGKLKMGFWDRPNLELLRAVGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---SPPR---------PPGPSVSAR------------A
GEPA--PGAPGE----A----TPQEDVGNPAVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVAALPSGLRGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KREEVRRLQQKKPQGQ-REHEGAVQLLEST--LDSMQVRVRELEEQCRSQTERFSLLARE
LQAFRLHPGPLDLL---TSALGCSAPGDRPPPPCCCLPQSQPQRPRV---I-FPVDLDLP
PASP-GRCTPKSSEPAS---------ATLAGVSRRTPAKRAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADNVSLLPA-V-----------
-AEGDRGGARVQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYVYIYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLASLPPELA--DLSHS-------------SGPELSF
LSSGGGGSSSGGQSSGGRSQPRPEDE---AAEEAPSPSPP---------PEGLGEPPAVP
YPRRLAVLKQLAHSVVLA---WEPPP---ERVELSGYHVCVN---GELR-QALGSRAPPT
A-VLENLDLQA-GPL-WVSVQALTSRGG------------SDPLRCCLLLGAQAGVAPSQ
LRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAVYADGQKIMEGAP---PTAGSVPGGAGRRQLLQACCAVAVRTMSPH
GESADSLPAPIAPALA-EASWPARVPCAC-----PRPGPEVRPPLAPASPGLGDPSSP--
---LRCPDPHGP-------QEAPGAPTASPPRETA---GGSSE-EP--PAPVSQ------
-----------------EQAGAAVLGAPGDMKATEPALGDCVPGPATSSMAKEDAEQTTG
E-AHLAPGT---TQGTLAQR---LPCVQACRGGDAGSGLRPRAEGED--AAELGVHPGNS
LVDQGRNSDLSDIQEEEEEE-------EEEEEELGVRTCSFPKQVA---GHSIGGQGAKP
Q-PD------PFCETDSDEEILEQILEPPLQHFRSKKLF-SIPEEEEEEEEEAG----EA
AQEEK-GPGAGSASRDPGP-----------------------------------------
------------------------------------------------------------
----XCSRLLSNG-G--GSQAPGRAPGPARERGGPAAAEGARAPPDAGGRARPAPS----
-------------R-KCPRGRAPE--PEPGL-ASCLSPKCLEIS------IEYDSED-EQ
ETGG-GDM-----SITSSGCLGDGEAWGAAPVGRPRAP----------------------
---PKAGSGPHSYPY--SPAWEKGEPERRGRSATGRA------KEPPPRSA-ESGEPRG-
LDSPGQSGSKR----RR--GWAPRPGSTEL----APPRSPPEASLALRDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRWGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAMDS
PAG----TQQLLQQGHLSPEALAEGS--VSGKGPPSPAQ-ARGRPTEDRRGVGVPRKSPE
SS----SSPPPEPPQL----A-SSASLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------SDREPG-AAPS
EGQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------WQPALPGPQDP---QAENS
SEDPLPDTASG-AHR-TPRGP-LRLGSP--DNLDAGVR--------V-------------
-----RSRSLERL--------REASLDSLATA-HVCSRDS-T-LNCPKA-SESEAPAS-S
TDTSAAGFPNSPPPR------------------AHRKLKDPS-GEGSGNRPPE-GLT--P
SLLGLCYRALVKRNSELSEALQKLAHCCSELREENLQLRRSGGPREEDEKVKLLKMKHAE
LAGLARRLEDRARKL-QETNLRALSAPVLG------ENRAGMELC-QALARQRARDLSEQ
ASALLAKDQQIEELKRECHLLQERVATGLDSPTQPAGGVP----RAQWLNL-SDLDRLQR
ESQREVLRLQRQLTLQQG-KGCAC--AEA-------------------------------
------------------------------SCRSTHCEES-RRRVQALERELDAQRRECK
ALGEQAA----------------------------------------AVAAENSDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------LGQNRQQQLQHDLEKALSDLQ--A
ARKEMQTLQDQPVHPP-QQPREATQAPVS---------QATGRGRH------KFQPQAED
CAPSRAT---KEQ------------------LPVCPTL------------QGSPAALGEP
GSSLLV--------------TDRLP--ASQPLDSRHQAKKTNSQS--TSSS---------
---------E-VEPMWATVP-SCFTLDVDTASEVDDLEPDSVAPSLGVRG----------
-PDA-PSTSKSKIFQARRSYNPFEGPSEHPES

PF14604 // ENSGT00390000017228_1_Domain_1 (1113, 1152)

ELPLTAGDYVYVSGDLDEDGFYEGKLAN
GRQG--LVPSNVL---GQLPDGSNLSNLSPRSLESPNHLG-------------PT--ILP
VGHS--------------KAS-------------KEASLL--L-----------------
----------------------------------GEARGSGD---RGPR-HMGTEGSKTE
K-AV---EIQR-ETCWLDSSQSIREQSF------------SIPTLG---TEGLPSVGPVQ
LHLQNVTATSAEIAWVCGSSRHPHVVYLDDQEHALTPSGGSCYTFQGLHPGTQYQARVEV
E--VGLPRDLEQEPRETMSSTITFSTPLAGPPDPPLDVLVEHH-TLAGFLVVSWIPVTID
SAGSSNGVRVTGYAVYADGLKVAEVTD---ATAGSILLEFSQLQVPRTCQKVSVRTMSLC
GESLDSVPAQIPEDCFTD-HSSPQTPPFSS------------------------TF----
------AFPIYR-------QK---MALASLSTQVG----------PLAPGSRGE------
----PQAKF--------PEVP--------------FEEPLRVHPAL-SNLSPEE------
A------G-------------------------KQAHGPSGAQK----------------
------------------------------------------------------------
-------------------GCRKDLPFHQCPQNHGPLP-PSGQSVMEEN---HYG-H---
-------RST---SRGSSPGFN-R-LS---------------------------------
---PKCGLRKEPCQE---------------------------------------------
--------QAAH------------EKALRQKQ------------------------DAQA
ST-----------------------PSQQGT-SHQ---YAANSC------SVL-------
--EEE--VCLDP--------------RYTEKQEQREKLRPPYR------------Q-GQ-
P-------T-----A---------------------------------------------
-------------------VLGPAPSSRIIKM----SWGGPPQLGPEANTPARVRM

PF07653 // ENSGT00390000017228_1_Domain_3 (2337, 2396)

ALFD
YNPLARSANPEAAEEALTFQRGQFLRVWGSRDPHGFYHGECSGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2510)

VEVGT
EQPD--KRWHTLTQGHLPSVGQLEDSEGPSR----P-----QDSFFRPQ-----------
-----------------RNSRRP--TLRTPKTMMVALDYDPGDREAGGP

PF07653 // ENSGT00390000017228_1_Domain_5 (2510, 2614)

AKGKLAPRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLIPAHLLEDLSGHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPR---L---GA---
----------------------------------------------MELWALPAWQHWTQ
---GQGCKPGDASPSI---P-TALQVKGLRSE------ESSK----SEGAHSPGPVGNTD
PEATETGLPKLGQQAESPG-----------YSCS--RLEGE---------AAQ--V---Y
-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLSL-------V--GKE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SPGPTASSR------------V
GAPA--PGAPGE----T----VLQDDVESPQVVLREP--EKQQRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCNALGDHPPPHCCCSI---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSTEPAL---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSISLLPA-A-----------
-PESHLGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLSTLPRELA--DSSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRHITVLKQLAHSVVLA---WELPP---ERVDLRGFQIFVN---GELR-QALGPGVPPK
A-VLENMDLQA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGAGARVVPSQ
LRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QIPSQGPWELGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESSDSIPAPVAPALA-SACQPARMSCLS-----PRPSPEVRTPLASVSPGLGDTSFP--
---TRHPVPHGT-------QDFP----ASLSIEMS---KGPQE-EP--PIPCSQE-----
------------------EAGVAVRSISEEKRAIEPTLGQEGPDPVAPSLAKQEVECPSG
D-AGPTPCS---TQGELTQK---EPSIEAGHGGDLDSGLKLRSEKEDMS--ELGVHLVNS
LVDHSRNSDLSDIQEEEEEE-------EEEEEELGSRPCSFQKQVA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQRLCSKKLF-SIPEEEEEE---------EE
EEGLE-KPGPSRSSQDPSQPELALLG-RGCDSSQPQ----GPGLCPLS------------
-PELSGAR---EHLEDVLGV---VGGN-SRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQTSARPV----PPRERGSLPVIEGTRVGQEPGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----SINSSCYPTDGEAWGTAAVGRPRGP----------------------
---PKVNPGPNAYLR--LPAWEKGEPERRGRSAMGRT------KEPPSRAT-ETGESRG-
QDNSGRRGPQR----RG--ARVPRSGATELAP----PRSPQ-EAPPHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQLLKVFGDKDADGFYQGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLRRGFLPPNVLTEAS--GNGPSVYSSAH-TPGPPPKPRRSKKVELEG--
-P----PQLCPGPPKL----I-HSAAQKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------L--ESG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPVWQSWTP
---GQGGEPGDISPNVADTPPAALQVRELRLE------ESFK----PKGAWSSGPMGAID
PEGAKAGLPGLGQQAASSG-----------PGCP--RLEDE---------EVE--P---F
PKAKLNMGFGDRPNPELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNLRVVSAPVPRP-------GATLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEP--S-PPSR---------PLGSAAGAR-AG-----A----
--PA--PGAPGE----A----TTQEYVDNPPVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEHEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVTQERDLALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAR-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDCGAPGDHPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ASLAGVPRRM-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPAELA--DLSHS-------------SGPELSF
LSGGGGGSSSGAQSSGGRSQPRLEEE---DAGGELSLSPP---------LEGLGEPPVVP
YPRRLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAAPK
A-VLENLDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGLVPGQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPRGPWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSSGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLHVCREVAVRTMSPH
GESADSIPAPVAPALGTPACLPAGVSCPS-----PRASPEARPPLAAASPGPGDPSSP--
---PQRPVPHGT-------QEPLEASPASPPRETP---KGSQE-EP--PAPCAQ------
-----------------EEAGAAVLGASEERRASEPAQGEGAPGPAAPSLAEQEVEWTSG
E-ARPAPCS---TQAGVAQQ---VPSPEACRGGDTGSGLRPKGEKEDAA--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE--------EEEEDEQGSRTCSFQKQVA---GNSIRENGAKP
-PSQ----PDPFCETDSDEEILEQILELPLQQFCRKKLF-SIPEEEEE------------
-EEEE-KPGAGCSSRDPGLPEPASLG-LGYDGGQPR----GPGQCPLS------------
-PEPCRAG---DHLEDMPGL---VGGS-SRRRGGGS-----------PEKPSSRRRP--P
DPREHCSRLLSNG-GPQASAR----PGPARERGGLPVVEGTRGGPEAGGRGRSGSS----
-------------R-RCPRGQA----LESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----SITSSCYHGDGEAWGTAPVGKSRGP----------------------
---VKVNSGPNPYPR--LTAWEKGEPERRGRSATGRA------KEPPSRPA-ETGEPRG-
QDSSGRRGPQR----RG--ARAPRPGTTEL----APPRSPP-EALAYQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLFQRGYLSPDVLVEG--SGNGPFVYSTAR-TTGPPPKPRRAKKAESEG--
-P----AQPCAGPPKP----H-PYADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------LDREPR-TPQA
DSQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------FCIFSRDGVS----PCWPGW-SPSLD--------
-PVIQPPQPPKVLGLQPYPSSGEVSAPLPRP-------GASLELCRKALASQRARDLSET
ARALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLYV-WDFDGLLR
ESQREVLRLQRQMALRNQRETPPLPPSRL---------PWGPVLRCQ-------------
--PL--APGHFQ----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCQ
SLEQEARKKQRRCEELV---RTAAERSAELVEENSRLSGRA--PEKEQVEWENAELRGQL
L--GVTRERDSALRKSQ--GLQSKLESLEQVLKHLREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGTVQLLKVG-RL---EARVRELEE---------HLLAQE
LQAFHLHPGPLDLL---TSALDCGSLGDCPPPRCCCST---PQPCRG---S---------
---P-GCCTPKSSEPAP---------VTLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVLLARYSYNPFEGPSENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYLYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERLSDDDLLTSLPPELA--DLPHS-------------SGPELSF
LSVGGGGSSSGGQST----------------------------------------SPAMP
YPRHLVVLKH----MMLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGA---
----------------------LSSRGS------------SDPLRRCLVVGARAGVVPSQ
LRVQRLAATSAKITWVPGNSNLAHAIDLNGEECPPASPSTCWATFCHLLPGTPYQAQVES
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKVAS------PTAGSVLVELSQLQLLQVCREVVVRTME--
--SADSIPAPITPALA-PASLPARVSCPS-----PQPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPASSS---TQGAPAQQ---APNTETCQGGDPGSGLRPRAEKEDTA--ELGVHLEE-
-----------------EEEEEEEEEEEEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PNPFCETDSDEEILEQILELPLQQFCSKKLF-KED-----------------
-EEEE-KPGAGCSSRDPDPPEPASLG-LGCDSGQPQ----RPGQWPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PENPPSHRPT--S
Q-QQWAPGLWTTG---------------------------PRT-----GEGAAGPF----
-------------L-EVLPRPG----AGAWL-ASCLSP-----N------TEYDLE---Q
EAGS-GGI-----SITSSCYSGDGEAWGTATVGRPRGP----------------------
---LKANSGPKPYAR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDSSGRRGPQK----RG--VRVLRPSTAEL----VPARSPS-ETLAYQHLPVRIS

PF07653 // ENSGT00390000017228_1_Domain_3 (2336, 2396)

VALFD
CDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSGMT---------SRTTGPPPKPRRSKKGCVCW--
--------------WV----LVPPADLKAPCS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYDPQESSPNMDVEAELPFWAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TPQA
ESQRMRRR----RLQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPSSAAPSVADTPPAALQLQELRSE------ESSK----PKRAGSSRPVGGTD
PEGAEACLPSLGQQPSSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPQP-------GTSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPL-PPSW---------PPGPALQAR-AGAPA-------
------PGAPGE----A----TPQEDADNPPVILGEP--EKEQRVQKLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGSLGDCPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAQPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PHPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGHAAPSLAKQEAEWTAG
E-GCPASSS---TQGALAQQ---APNTEMCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEEEE------EEEEEELGSRTCSFQKQIA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KSGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----LGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------VEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPR--LPAWEKGDPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDSSGRRGPQK----RG--VRVLRPSTAEL----VPARSPS-ETLAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTSR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----A-PSADLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVY----HIPAPQTSDRG------IGKEPS-GSPE
EWNGSPPW----TVVLA-----LAVPQGHQSQGAG-PEPLS-------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLMSSVAPELM--DLSHS-------------SGPELSF
LSGGGPA-SSGGQSSGGGSQARPEEERS-----DLS-------------PSPLLEPPAVP
YPRHLAVLKQLAHSVVLT---WEPPL---EGADIQGYHVCVD---GKLH-QALGPGTPRK
A-VLEPLDLQA-GSC-CVAVQALTSQGS------------SDPLRCCVMVGAGAGLAPSQ
LRVRRLTATSAEITWVPSNSNLAHAVYLNGEECPPARPGTYWGTFCHLRPGTPYQARVEA
RPVSLGPSEPSWEKLQNRAAVIHFTTLAAGPPDAPLDVQIEQG-PSPGILVISWLPVTID
AAGSSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVDLSQLQLLWVCREVVVRTMSPH
GESVDSIPAQLPPALA-LACPSPPALRTSAAALLPSTSPEAKSPPCPASLGPGDPGPL--
---PQHHGPPGS-------RDTAGDLPDSPSKTVE---RTPHEDSA--Q-DKMQG-----
---DTGAL---------TAAGLAA-GSKKSQSPGLSLLGKKEEEEEAAAV----AVKGPG
------ESP---APGAPAER---ILGLEP-GRGEIGPGPRARVEQRE-DATEVGARLTNS
LMDHGRSSDLSDIQEEEEEEEEEEEPE--P----GAECLSP--LQN--EQTITRETGAKL
----------DSCETDSDEEILEHILELPLQQFCSKKLF-SIPEEEEDEVEEEKEE----
--KEEEKKGAGGSLTCTRLPEPQGVG---LNRSGNR--LWELRPSLST------------
-PDSSLGR---DPPEELIPCQAGGSPLGSRRRGGGS-----------PEKLSARKRP--P
DLREQCSRLLGSS-GTQGSGR----SGPSWDRGAPSSSEGVKCGTEIGGKGWPGLS----
-------------R-RCSRGLA----PDSSL-ASCFAPKCLEIS------IEYDSED-EQ
ESVGSGNS-----IFSSSCCPRDGEGWGMGPEGVPLGGRH--------------------
GA-PGANPAPSHCLR--LSSCEKGEPERKGRSLNCRV------KEPCLRTA-EPRELRG-
QDAAGQRGPPR----KG--SRPSKLGVAELAF----PRNQA-KVMSPPNESVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAVEEELPFREGQLLKVCGEKDADGFYRGECGGRVGYVPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2495)

VAVGS
PAV----KRQLLQRGYIHPDSPKEGL--GNGSFPLLAPH-PTGPPPKPRRSKKGSHSQPE
----------------------ARASPSTPHSVV

PF00018 // ENSGT00390000017228_1_Domain_5 (2495, 2611)

AAFDYNPRENSPNVDVEAELSFKAGD
IITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGAVTGEDKRVAGPPKEKDSG-GHTA
ESQRMRKR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPQLGDP---RA---
----------------------------------------------MEPWALPAWQNWTP
---GQGSEPGGAAPSIAEIP-AAGQVGELRPG------ESSE--PEPEGAQSPGAMGGID
PEGTKTGLNSLGHQAASSR-----------PSCP--RLEDE---------EVE--A---L
PKGKLSMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPVPRP-------GASLELCRKALAHQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPP---PPPR---------PPGPAAP------ARAGA----
--PA--PGAPGE----A----RPQEDVENPPTGLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARISLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLEVL-----AQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGYSTLGDHPPPPCCCST---PHPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPVP---------ATVVGVPRRT-AKKAESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSAGGGGSSSGGQSSGGRSQPRPEDE---AAGDELSLSPQ---------PEGLGGPPAVP
YPRGLVVLRQLAHSVVLA---WEPPP---ERVELRGYHICVN---GELR-QALGPGVPPK
A-VLENLDLRA-GPL-RVSVQALTSQGS------------SDPLRCCLVVGTRAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRESWEPGWERPEQRAATLQFTTLPTTVIQTPDKTCQGLS-VLPGIMLTAV------
--ANHHRVFDSATSTSTLYLQIMEVAS---PTAGSVLVELSQLQLMQVCREVAVRTMSPH
GESADSIPAPVPPALV-AACLPATVSCPS-----PRPGSEARPPLAPASPGPGDPSSP--
---LRRPDPHGT-------REPPGAPPASPPREAA---KG-SPEEP--PAPCSQ------
-----------------EEAGAAVLGTSEDGRASEPAVGERAPDPAASPLAQEE------
--ALLAPCS---TQGALAQR---VPCAEACRGGEAGSGLRPRAEREDTA--ELGVRLVNS
LVDHGRNSDLSDIQEEEEDE-------EEEEEDLSSRTCSFQKQVV---GNSIGENGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEEDEGE---D
EEDEE-RPGAGCSSRDPGPPESALLG-LGCDSGQPR----GPGLCPLS------------
-PEPCRGG---DRLEDIPGL---VGGS-IRRKGSGS-----------PEKPPNRRRS--P
DPREHCSRLLSNG-GPQASGR----PGPTRERGSPPVGEGTKGVPEAGGRGRPAPS----
-------------R-RCSRGRA----PESSL-AGCFSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTAPIGRSRGP----------------------
---LKANSGPTPYPR--LSAWEKGEPERRGRGATGRA------KEPPSRAT-ETGEPRG-
QDSSGRRGPLR----RG--AQAPRT---------ASLRSPPAEAPVYQDLPVRA

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PTE----RQQLLQRGYLSPDILTEG--LGNGPFVYSTAR-TAGPPPKPRRSKKAEAEG--
-S----AQPCAGRPQQ----V-SSASLKSSRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
IITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------SDREPG-TSQA
ESQRMRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQLGDP---GA---
----------------------------------------------MEPWALPAWPCWTQ
---GRGCEPEDAAPSVAGTP-TAPQVRGLTSE------ESSE----PEGAHSPGPVGNTD
PEETAAGLPKLGQQAESRG-----------YSCP--RPEDE---------EAQ--V---C
-KAKWNVGFGVRSNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLAL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RSAR---------PPGPTALSR------------V
GAPA--PGAPGE----A----VLQDDVDSPQVVLGEP--EKQRRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQHENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVKQERDSALQRSQ--GLQSKLESLEQVLKHMREVAQRRQQLQVEHDQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-V-G-----ARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPHCCCSA---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------ATLAGVPRRT-AKKVESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGNSGGARVQVFLARYSYNPLEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DLSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---ATGDELSLSPP---------PEGLGESLAVP
YPRRLTVLKQLARSVVMA---WELPP---ERVDLRGFHIFVN---GELR-QVLGPGVPPK
A-VLENMDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRIHRLTATSAEITWVPGNSNLAHAIYLNGEECAPARPSTYWATFGHLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQVEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACREVTVRTMSPH
GESTDSIPAPVAPALA-PACHSARMSCLS-----PRPSPEVRAPLASVSPGLGDPSFP--
---LRHPAPHGT-------QDPP----TSLPMETS---KGSQE-EP--PVPCSQE-----
------------------ESGAAVPGISEEKRAIEPALGWEGPGPVASSLAKQEVEWTSG
E-AGPVPCS---TQGEPAQK---APSTETCHGGDVGSGLKLRAEKEDVA--ELGVRLVNS
LVDHGRNSDLSDIQEEEE--E-----EEDEEEDLGSRPCSPQKQVA---GNSIRENGAKP
---Q----PDPLCETDSDEEILEQILELPV-QLCSKKLF-SIPEEEEEE-------EEEE
EEGQE-QSEPASSSQDPSQPELALLG-LDCDSSQSQ----GPSLCPLS------------
-AEPSGAR---EHPEDVLGV---SGGN-SRRRGGGS-----------PEKPPNRKRP--Q
DPREHCSRLLGNG-GPQIIARPG----PPRERGSLPVIEGIRVGQEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EL
EAGS-GGI-----GITSSCYPTDGEPWGTAAVGRSRGP----------------------
---LKVNSGPNPYLR--LPAWEKGEPERRGRSATGRT------KEPPSRAV-ETGESRG-
QDNSGRRGPQR----RG--ARVPRPATTELAP----SRSPP-EAPAHQSLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDSDGFYRGESGGRTGYIPCNMVT

ENSGT00390000017228_1_Linker_3_5 (2395, 2493)

EVAVDS
PAG----RQQLLQWGFLPPDVLTEGS--GNGPSVYSSVH-MTGPPPKPRRSKKAELED--
-P-----QPCPGPPKL----V-HAAVLKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--ESG-TSQA
ESQVSEER----AYQLSILPTLRVF-----------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPRKLGCSSRAAAVLENQRRELEKLRTELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQTALEVERQLFLKYILEHFRRNPALSEPANP---QAVHC
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSIPGSQSLPPPPSPLRPPPP--------PSDHRKLSNQQGGEGSESQPCK-VVT--P
SLPGLGHQELIKLNWLLAKALRVLARRCSTLQEENQQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPVPG------ESCVDLELC-QAFARQRARDLSEQ
ASALLAKDKQIEDLRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAW--PEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALESELVQRRRECE
ELGAQAAAARLRGEDAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVCGQV
G--RACQERDAAGLMAE--QPLQQAA----------RGQDRQQQLQCDPQKALYDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSGRP------KFQARPED
YTVSQPNRDIHEK--------------------REVSL------------EENPVALGEP
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTMDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGP

PF07653 // ENSGT00390000017228_1_Domain_1 (1107, 1157)

NDHPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLG-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RELY-QMVKVGSKTE
V-ATEILYTKM-EACQLGLLQSTGKQGL------------SRSLLG---TKGVLCMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTLAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDWFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNTGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECLSSG
A------S-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLFFQKSPQHHRRPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDL--------------WGTERQEDRREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFCLSECNRQVGNIPGHPVAEMEVGT
EQTD--RTRRLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPRDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVYGPVDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHRH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWHSWTP
---GRGGEPSSAAPSIADTPPAALQLQELRSE------ESSK----PKGDGSSRPVGGTD
PEGAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
LKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GTSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETLPL-PPSW---------PPGPALQAR-AGAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLES--TLDSMQARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGSLGDCPPPPCCCSI---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSVGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---EQVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLWA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PHPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMA---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPASSS---TQGARAQQ---APNTEMCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEEEE------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KSGAGCSSRDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----LGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDGSGRRGPQK----RG--VRVLRPSTAEL----VPARSPS-ETLAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAH-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSADLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VLREREAEIRQLLRWKEAEMRQL
QQLLHRERDGVVRQARELQRQLAAELVNRGYCGRAGAP---------KAAAAAQCRCRLQ
EVLAQLRWETDGEQASRIRHLQAALDVERQLFLKYVLEHFRWHPVLPGTPDP---QAVPS
SEEPHPETASD-SHR-PPKSPKVRLES--LDGLSAGVR--------VRSRSLEMVPA---
---ACSNSRDNLLP----T--RSGSLDSLAPG-RSHSLDS-L-LGRPKA-PESEERAS-S
ADTFILGFLSPPPPPTSPPPPPTPTPPLSP---PPRGPSDRT-GEDSRSQPCE-ALA--L
SPLSLDYQELVKQNSELSEALQVLARRCSDLLDENMQLRRTGFPDQADEKVKRLKVKHAE
LTGLARRLEDRARKL-QETNLRTLSAPVPG------ESRVGLELC-QDFASQRARDLSEQ
ASALLAKDKQIEELQQECRLLQAHVASGLGSAPHADGGAA----SAQWLKV-SDLDRLQR
ESQREVLRLQRQLTLQKAT-RSGR--GEP-------------------------------
------------------------------SGRKAPGEGA-RCQVQALERELSARRQECQ
ELGAQAAAAQRRGEEAEAQLQTALCEGAWLAKENARLQAQA--DWTRKLAAENNDVREQL
G--RACQERDATGLLVE--QLLQQAA----------REQDKQQQLQRDLQKALRDLE--A
ARGEMGVLRCQPDHHP-QQPLETSQAPDS---------QGRKSRKT------RFQPGPED
QASLQSSRDKQEE---------------------DASL------------LESPLALGEP
ASAPQG----------PDRVPDRVP--ASQPLDCRPQAKKTSSQS--NSSS---------
---------E-VESVWATVP-SCLTLDMDTASEVEDLDPDSASLTLEVGD----------
-SEA-PAAPKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLVRYSYNPFEGPNEHPETELPLTAGEYVYIFGEMDEDGFYEGELED
GRRG--LVPSNLV---VQIPDNDILGCLPPESS----DPG-------------PT--QLP
AGQG--------------KTS-KE---------DISHSFL--P-----------------
----------------------------------GEAQGAVD---RETC-QMARAASKTE
V-AMETSDAKT-EDGWLGSRRSVEEQGF------------SRPLLG---PKGVPCVAPKQ
LRVQNVVATSAKIVWVYSSCCRPHVVYLNDQKHALTPAGVSTYTFHNLHPSTRYQVQVE-
---VQLPWDSMQMRWETMSSTLTFDTPLAGPPDPPLDVLVER-HTLPGLLVVSWLPVTID
LAGFSNGVRVTGYAVYADGLKVAEVTD---ATAGSTLLELSRLQLPLMCQKVSVRTISLC
GESLDSVPAQIPQDCWNC-NGLPETSPFTYT--------------------PGDQSPC--
----RITFPVCP-------QR---LALAPPSAKAS----------SHIPRSCGG------
----S------------LEAF--------------PEEPPRKHSPM-PNLSPEGECPGAG
A------G-------------------------SQTQGPAEAWE----------------
------------------------------------------------------------
-------------------VCRKDLLFQKSPRNHRPSL-H--QSQGEED---HDR-H---
-------MDT---SQSPALGVL-H-LS---------------------------------
---PEFAPRREACQE---------------------------------------------
--------KAAL------------EKALRQKQ------------------------DAQV
LT-----------------------PPQIGT-RQR---HMSDFH------DIL-------
-QQEEEAACFGP--------------WATERQEQRRELRAQSR------------R-GQ-
ALWGERESQLQEPSS---------------------------------------------
-------------------APCPASSSKVLPV----SGGGPPQLEAGRDTAG

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YEPLVMSANPEAAEEELAFQKGQLLRVWGSQDTHGFYRGECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VEDGL
ERTD--SRWHLPVQGHLPSVAHLDEVGGLTI----P-----QDSFPLPQ-----------
-----------------GNPRGP--PLCTR

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

MTMMAALDYDPKDGWAGGQAKGKLSLKAGD
LVTVYGPVDDRGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDYMSLHDE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---IAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKX----XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXX--X-XX---------XXXXXXXXX------------X
XXXXX-XXXXXX----X----XXXXXXENPPVVLEDP--EKQQRVQQVESELSKKRKKCE
KLEQEARKKQRRYEELELQLREAQTENARLVEENSRLSGRA--TEKQQXXXXXXXXXXXX
X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXX---XXXXXX---X-XXXXXXXX
X--X-XXXXXXXXXXXX---------XXXXXXXXXX-XXXXXXXX--XXXX---------
-----------XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX-X-----------
-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXELVD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELNF
LSGGGGGSSSGGQSSGGRSQPRPEEE---AAGDELGLSPP---------PEGLGEPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRGLAILKQLPHSVVLA---WEPPP---KQVELRGYHICVD---GELR-QALGPGAPPT
A-VLENLDLRA-GPL-RVSVQALTSRGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDPLRCCVALGARAGLVPSQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRGPREPDWERLEQQAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-----XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXDPSS--
---LRCLTPGGT-------QEPPGAPPASPSRETP---KRSQA-ER--PAPCSQ------
-----------------EEAGAAAPNASGDRKASEPSLEEQVPGPAVSSLAKEEAEQTAG
E-ALPAPGS---TPAALAQR---LPCAEACRGGDTGSALRPRAEREDTA--ELGVRLGNS
LVDHGRNSDLSDIQEEEEE-----------EEELGVRTCSFQKQVA---GNSIREKGAKP
E-------PEPCCETDSDEEILEQILATET------------------------------
--------------------------------GEP-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------RG-
QAGCGRRGPLR----RG--ARGSRPGPTEL----APPRNPPEAALAYQDLPI

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YDPVSMSPNPDAGEEELPFQEGQILKVFGDKDADGFYRGEGGGRMGYIPCNMVAEVAVDS
PAG----RQQLLQQGYLSPDVLVEGP----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAAR
ERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVG--------VRSRSLGLVSS---
---ACSSSPDGLLS----T--HASSLDCFAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPRGGEGSESQPCE-VLT--P
SPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRAREL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLMLQQGN-GGA--WPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASGLIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH--P
SWKEIQALQCRPGHPP-EQPWETSQMPES---------QVKGSRRP------KFHARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SSPTLDRDTASEVDDLEPDSVSLALEMGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELDD
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PS--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGMVD---RGLC-QMVRVGSKTE
V-ATEILDTKT-EACQLGLLQSMGKQGL------------SRPLLG---TKGVLRMAPMQ
LHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVE-
---VRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTVLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LSLAPPSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPS-VSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KAAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NVLKE-----
---EQEALCLDL--------------RGTERREERREPEPHSR------------Q-GQ-
ALGVKRGCQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSPAQGHLPSVAHLEDFQGLII----P-----QGSSLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPADP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRAGEPGGAAPKVADIPPAALQLRELRSE------ESSE----PKGAQISRPLRGTD
SEGAEAGLPNLGQQASSSG-----------PTCL--RPEDE---------EAE--A---F
PKAKLNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPFPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPAPQAR-AGAPA-------
------PGAPGE----A----TPQEDVDNLPVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQSENARLVEENSRLSGRA--TEKEQVEWENVELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAR-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDFGTLGDRPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-TKKAESLS--TSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEADSVSLLPT-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DWSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDELSLSPS---------PEGPGEPPAVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVELHGFHISVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPQGPWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQACREVVVRTMSPH
AESADSIPAPITPALA-PASLPARVSCPS-----PRPGPEARAPLASASPGPGDASSP--
---LQHSGPLGT-------QEPPGAPPASPSRELP---KGVHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTATTSTLGEKDPGHAVPSLAEQEAEWTAG
E-ASLAPSS---AQGALAPQ---GLNTEMCQGGDPGSGLRPRAEKEDTA--ELGVHLLNS
LVDHSRNSDLSDIQEEEEE--------EEEEEELGSRTGSFQKQVA---GNSTRENGAKS
---Q----PEPLCETDSDEEILEQILELPLQPFCRKKLF-SIPEEEEE-----------E
EDEEE-KPGTGCSSRDPGRPEPALLG-LGRDSGQPR----GPGQSPLS------------
-PEPFRAG---DCLEDMP------GGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQAPGR----PGPARERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGWA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGS----------------------
---PKANSGPKPYPH--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGESRG-
QDGSGRRGPQK----RG--ARVPRPSIAEL----VPVRSPS-EALAYQHLPGRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDMLLESS--GNGPFVYSTAR-TAGPPPKPRRSKKAESEG--
-P----VQPCPVPLRL----V-PSADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGSGPEAGG------LDREPR-TSQA
ESQVST-------VSCKEP---L--SDHQRGAPPG-SCTPVCTLCRGVIA----------
-------V---------TLTPRPSDLAANTWGLTQVRGPEEK-DPSGQSKLLFQPLPPWG
SSCLPGAFGSQLPSQAQLPGFSFLELASPWGGWNTTKLPPSEGRERE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGNP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAVPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLNGKV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPAPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEEEE-----EEEEEEELGFRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSEE-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRGPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSAELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPAPQTSQGG------LSQSWA-GGWA
RNPQE-VW----WNGMGHLPGQWFWPQ---------------------------------
--------------------------------LFPRGIRV------------EG------
---------QS------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDL---GT---
----------------------------------------------TEPWVLPAWHSWIP
---GQGGEPGDTAPSIADTP-TALQVRRLRPE------ESSE----PEGTQSPGPVGNTD
PEGPEAGLPWLGQEAAVFG-----------CSCP--RLEDE---------EVQ--A---L
RKAKLNMGLGDRPNLELLRALRDLQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNLRVVSAPVPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIATLQRECRELQARLSL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---PPPR---------PPGSTVPSR------------A
GAPA--PGAPGE----V----TPQEDVDTPPVILEEP--EKQQRVQQLESELSKKRKICE
NLELEARKKQRRCEELELQLREAQNANARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTRERDSALRKSQ--GLQSKLESLEQALKHMREVAQRRQQLEVEHEQARLSLL--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPPCCCST---PQPGRG---S-GPKDPDLP
PGSP-GRCTQKSSELAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEVDSISLLPA-A-----------
-PEGNPGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPAELA--DLSHS-------------SGPELSF
MSGGGGGSSSGGQSSRGHSQPRSEE----AAAEELSLSPP---------PEGLGESLTAP
YPRHLMVLKQLAHSVVLA---WELPP---EKADLRGFHVCVN---GELR-QTLGPGAPPK
A-VLENLDLRA-GPL-QVSVQALTSRGS------------SDPLRCCLAVGAGAGVVPRQ
LRIHRLTATSAEITWVPGNSNLAHAIYLNGEECPRARPSTYWATFCHLRPGTLYQARVEA
QLPPWGSWQSGCERPEQRSATLQFTTLPAGPPDAPLDVQIEAG-PSPGILTISWLPVTID
AAGTSNGVRVTGYAVYADGQKVMEVAS---PTAGSVLVEVSQLQLLQECREVTVRTMSSH
GESADSIPAPVAPALV-PACQLARGSCPS-----PRASPEVRTPLAPASPGPGDPSSP--
---LRYPSSHGT-------QDPP----ASPSMETS---RGPQQ-ES--PVPCPQQ---GQ
AWRQPGVRAFTQCHSLQEEARAAVLGASQERRTSELSLGEGGPGPAVPSLTKQEAEWTSG
E-ASP-------TQGALAPR---VPSAEVCHGEDLGSGLRP--TKEETT--ELGVRLVNS
IVDHSRNSDLSDIQEEEEE--------EEEEEDLGSGTCSLQQQVA---GNSIRENGTK-
--------PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEEDKE-------
EEAEE-KPGAGSSPQDPGQPELALLE-LGCDSGQSQ----GPGPCPLS------------
-PEPSMAR---DYPEEMPGIL-LLGGS-SRRRGGGS-----------PEKPPNRKRP--P
DPREHCSRLLSNG-GPQASARPS---NTPRERGGLPVVEGTRGGLEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------VEYDSED-EQ
EP----GL-----GITSSCYPADGEAWDTAPLRRPRGP----------------------
---LKVNSGPNPYLH--LPAWEKGEPERRGRGTTGRT------KEPPSRAT-DTGEPRG-
QDNSGRRGPQR----RG--ARAPRDFPLPPPAL-SPPRNTP-EAPAHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGEKDADGFYRGEGGGRVGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLSPDVLTEGS--GNSPFVYSTAR-ATGPPPKPRRSKKVELED--
-S----AQLSPGPPKL----I-TSASLKVPRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPWENSPNMDVEAELTFKAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEVGG------PEREPG-ISQA
ENQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPIPLGGGPASLKKPGSPGPAASVLKEQKRELEKLRAELDTERARGQAERRRFATQ
ARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHRERDGVAQQARELQRQLAQELLNRGYCRLGGAS---------EVP-AAQCRCRLQ
EVLALLRWETDSEQAARIRHLQAALAVERQLFLKYVLEHFRWQPALPAHADP---QVALS
LEEPTPEAQSN-PRR-TPKPS-GGVGSL--ESQSAGVR----------------------
-----VH---DLLP----T--RACSLDSLATAEHAGSFDS-T-LSCPKT-PESEVEAS-S
TNASIPGTASPPSQPL----------RPS----THRKPRDLL-EESSENKPCE-------
----------------LAEALQVLARRCWDLREENVQLRRAGFLGEADEKIKWLKVKNAE
LTDLAQRLEDRARKL-QETNLPAVSSPELG------ESLEGLELS-QAFARRRAQDLSEQ
AGALLAKDQQIEELRRECHLLQARIATDLGSSSHSGEGAH----CAQWFNV-SDLDRLQR
ESQREVLRLQKQLTLHQRKVG-SE--AKE-------------------------------
------------------------------GSLSEQLEEA-RHQVQTLERKLDAQQRECE
DLSSQAAAAQRRCQDAEAQLQAALRQGAWLSEENARLQVLT--NWVKKMADDNSNVPQQL
SRGRQGPEVEATSLLVE--QLLQQAM----------CGQDRLQQLQNYQNKTPSDLQ--V
ARKEIRGLQCQSDHIP-EP-LETTQVPES---------QARGSKRP------KFKPKSEA
QAVSLPSRVIQ-P------------------PPVCLFL------------KENPVALGEP
SSVPQV--------------SDRNP--VSQPLDSRFQVKKSSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSVSNPMELRD----------
-PEA-PTTPKLKTFLARYSYNPFEGPN

PF07653 // ENSGT00390000017228_1_Domain_1 (1108, 1159)

EHPEGELPLTAGDYVYVFGDMDEDGFYEGKLVN
GQRG--LVPSNLV---EEISGSPVLSCPLSKSP----DLV-------------PT--SLP
AGNS--------------KTL-------------KKDSLL--L-----------------
----------------------------------GEVQESLE---RGPC-QVERADSKTD
T-AIELLETKT-EACWLGSLLRVEEQSF------------PRPLLE---TKGMFCVAPMQ
LQLQSVTATSAKITWVCGSSRYSHVVYLEDQEHTLTPSGVNCYIFQGLCPGTCYRVRVG-
---VHLPRDLLQVLWERVSSTITFDTPLAGPPDPPLDVLVEHH-TSPGFLEVSWLPVTID
STGSSNGVQVTGYAVYVDGFKVAEVAD---ATAGNTLL--SQLQVPLPCQKVSVRTVSLY
GESLDSVPAQIPEACFSY-YPFLGIPPVIA------------------------------
-------SPVCH-------QK---LFWASLSTKAG----------LHTPGSCGE------
----PQAKF--------LEAF--------------PKEHPRKQSPV-SNLNSEG------
A------S-------------------------NQAQDPIETQK----------------
------------------------------------------------------------
-------------------DYGKDLSFQRSPQNHKPPL-PCGQPGVED----HSQ-H---
-------MCT---SGSPPSGVF-P-LS---------------------------------
---TELGPGKP-------------------------------------------------
-----------L------------EKSLRQKQ------------------------NAEM
FT-----------------------PYQQGS-SQC---YSSDLH------HVL-------
--EK-KAICSYS--------------QCTAKLQERKNKP-QSG------------Q-RQ-
APGGKRE-----------------------------------------------------
-------------------PLCPVPTSKVIKM----SSGGPKQLETEGNTPVRVFVALFD
YSPLIMSVNHKA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2395)

AEQELAFQKEQLLRVRGSRDPHGFYHGECNGQVGKIPGHLVT

ENSGT00390000017228_1_Linker_3_5 (2395, 2498)

EVEVGT
EETD--KRWYLPAQGHLHSEAQFEDFEGLTN----S-----QGSFLMPQ-----------
-----------------GKSRTP--MLWTPKTMVAAL

PF07653 // ENSGT00390000017228_1_Domain_5 (2498, 2612)

DYDPRDGRAGFQAKDKLVLRVGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GECGGHRGLVPAHLLDDLFVRGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRPGDP---GA---
----------------------------------------------MEPWARPAWQSWTP
---GQESEPRGTAPSIAETP-AALQVGESRPE------ASSEASSEPEGARSPGPMGGID
SEGAEAGLPMPGWQAESPG-----------AGCP--RLGDE---------EVE--A---F
PQAKLNMGFGDRPNLELLRALGELQLRCAVLKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPRP-------GASLELCRKALARQRARDLSET
ASVLLAKDKQIAALQHECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPS---PPPR---------APGRAARAR------------A
GAPA--PGAPGE----V----SPQEDVDNPQVVVGEP--EKQQRVQQLESELSKKRKKCE
SLEQEGRKKQRRCEELELQLREAQSENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTEERDLALCQSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLK--E
KQEEVRRLQQAQAEAT-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGEHPPPPCCCST---SQPCRG---R-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLAGISRRT-TKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PKGTQGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDEDLLTSLPPELA--DLSHS-------------SGPDLSF
LSGGGGGSSTGGQSCGGRSQPRPEEE--EDAVDELSLSPP---------PEGLGETPAVP
YPRHLAVLKQLAHSVVLA---WEPPP---ERVELHGYHICVN---GELR-QALEPGAPPK
A-VLENLDLQA-RPL-HVSVQALTGQGS------------SDPLRCCLAVGARAGAVPSQ
LRVCRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPDTLYQARVEA
QLPPQGTWEPGWERPEQRTATVQFSTLPAGPPDAPLDVQVEPG-PSPGILIISWLPVTID
AAGSSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLRVCRHVAVRTMSPH
GESADSIPAPVAPALA-QAFLPARVS--S----SPRSGPEARPPATPASPEPEDPSSP--
---LRRPTPRGT-------REPPGGPPASPPRETS---RGSRE-GP--PAPCLQ------
-----------------EEAGAAVLGTSVERSANEPSPGERGPGPAAPSVAQERGAWALA
E-DRPLPGS---AQGALAPR---TPCPEACLSGDQGSGLRAKAEREDTA--ELGARLASS
LVEHGRNSDLSDIQEEEEEGE---EEEEEEEEELGTRHASFQKQVA---GNSIRESRAKP
---Q----PDSWCETDSDEEILEQLLELPLQPFCSKKLF-SIPEEEEEEEEEEEDEDDQD
EAEEE-KPGSGLSPRDPCPPEPALLG-PGCDSSQPR----RPGPSPLS------------
-PEPCRAG---DRPEDVPAL---VGGS-SRRRGGGS-----------PEKPPNRRRP--L
DPREHCSRLLGTG-GPQASAR----AGATRERGGPAAGEGPRAGPEAGGRGRPAAS----
-------------R-RGPRGQA----PEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGG-GGG-----AVTSSCHPEDGEPRGAAPLGRPWGP----------------------
---LKANSGPNPYSR--PPAWERGEPERRGRSATGRA------KEPPSRAT-ETGEPRG-
QDGSGRRGALR----RG--GRPPRPGSCDLALSTAPLRSPLEEAPACQDRPIRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVTMSPNADAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAEVAVDS
PVG----RQQLLQRGYLSLDVLHEGP--GNGPFVYPTNH-TMGPPPKPRRSKKGP-----
-------------SKP----G-SSVDLKAPHSMVAVFDYNPRENSPN-------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTEDSPTPLGGGRTSPKKPGSPGQAAAMLEEQRRELEKLRAELEEERARGRAERQHFTTQ
ARRLREAAERERQQLADHLHSKWEAQRFRELRQLQAEVQREREAEIRQLLRWKEAELRQL
QQLLGRERDGVVRQARELQRQLAQELVNRGYCSRPGAP---------EIP-AEQCRCRLQ
EVLRQLRWETDGQQAARIRHLQAALDMERQLFLKYILEHFRWQPALPGSPDS---QAENS
SRAALPETASS-ARH-TPKPA-FRLRLP--EAL---SG--------S-------------
-----P---DRQHP----A--RASSLDSLTAA-HSRSLDS-M-RSCPRAFIESKAPTS-S
TKVFVAGSPNVSPPR------------------AHRKPKDLG-KEGSGNQPPE-SLM--P
SPPGPDYCALVKRNSELSEALQRLTHRCSELREENLQLRRSGGPSQ-DEKVKRLKMKHAE
LAGLARRLEDRARKL-QETNLRALSAPVLG------ENRPDLQLY-QAFARQRARDLSDQ
ASALLAKDKQIEELRQECHLLQARVATGLDSTLNPAGGVP----RSQWLNV-SDLDRLQR
ESQQEVLRLQRQLTLQQG-KGCAR--AET-------------------------------
------------------------------SNQSATSKES-RHQVRALAFELDALRRECE
ALGAQSAAAQRRSEEVEAQLQAALRKGAWLAEENARLQTQA--HWVRRVVAENSDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------LEQNRQQQLQHDLEKALSDLQ--A
ARKEVQALQDPPGHPP-QQPQEATQ--------------ATGRGKH------KFKPQTKD
YATSQPS---KEQ------------------PPVCPTM------------QETPVSLGEP
ASSHFV--------------PESIP--ANQPLDSRHQASSQ----S-TSSS---------
---------E-VESVWATVP-SCLTLEMDTTSEVDDLEQDSVSPPLEVRD----------
-PEA-PSTSKLKIF

PF07653 // ENSGT00390000017228_1_Domain_1 (1095, 1157)

QAKYDYNPFEGPNEHPEHELPLTAGEYVYVFGDLDEDGFYEGELED
GRQG--LVPSNLV---EQIPDSPNLSNLSPKSSESPNHLG-------------PK--ILP
VGQT--------------KAS-------------KEASLL--L-----------------
----------------------------------RETQGSVD---RATC-QMGGKGSKTE
K-ATEILEIKR-KVCWLDSSQSMQEQSF------------SIPSPR---TKGLPCVWPMQ
LQLQNVTATSAEITWVYGSSKHLHVVYLDDQEYALIPSGVSCYTFEDLRPGTQYKARVE-
---VELPWDLQQIPWEMKSSTITFSTPLAGPPDPPLDVLVEHH-TSPGFLVVSWIPVTID
SAGSSNGVQVTGYAVYADGLKIAEIPD---ATAGSTLLEFSQLQVPLTCQKVSVRTMSLC
GESLDSVPAQIPEDCFTY-HLLPETLSFND------------------------TF----
------TFPICH-------QK---MALASLSTKAG----------SHIPGSCGE------
----PQTKF--------PEVL--------------PEEPLRKQSLS-SNLSSEE------
V------G-------------------------KQAQGFTGIQK----------------
------------------------------------------------------------
-------------------GCRNDLSFQKSPQNHRPLH-PSGQSVMKEN---HYG-H---
-------MST---SRGSSPGFI-H-VS---------------------------------
---PKCGPRKDLCQE---------------------------------------------
--------KTAL------------EKVLRQKQ------------------------GTQV
LT-----------------------PSQQST-SQK---YAAESC------NIL-------
--EEM-WRDVDN--------------WCTEKLEHREKCRPQNR------------R-QQ-
P-------S-----T---------------------------------------------
-------------------AQCPAQSSKVIEM----SCGVPSHLGPEANTLART

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPLAMSANPKAAEKELAFQKGQLLRVWGSQDPHGFYHGECNNQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2505)

VEVGT
EQPE--RRWHLPAQGHLSSVAHLENFEGPTS----P-----HGSFLKPQ-----------
-----------------ENSRKS--TLWTPKTMMVALDYDPRDR

PF07653 // ENSGT00390000017228_1_Domain_5 (2505, 2612)

KVGGRAKGKLALRAGD
MVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLIPAHLLDDLSVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAASVLENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFGRNPALSEPADP---QAVHS
LEERLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PNTSIPGSQSLPPPPSPLRPPPP--------PSVHRKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCASLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARIASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHV
G--RACQERDAAGLMAE--HLLQQAA----------RGQDRQQQLQCDPQKALCDLH--A
SQKEIQALQCQPIHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SVA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----ALR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------FRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDQEHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKDS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTEKQEKRREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RTWCLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAAVDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKDAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLRYILEHFRRNPALSEPADP---QAMHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PDTSIPGSQSLPPPPSPLRPPPSPR-LPPLPPSVHRKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPVPG------ESCAGLELC-QAFACQRARDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHV
G--RACQERDAAGLMVE--QLLQQAA----------RGQDRQQQLQCDPQKALCDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSIRP------KFQARPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYDPFEGP

PF07653 // ENSGT00390000017228_1_Domain_1 (1107, 1157)

NDHPEGELPLTAGDYIYIFGDTDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DPR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPLCP-------QK---LALAPLNAQAS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECLSSG
T------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGA---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KVAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPELGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERWEPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAKEELVFQKRQLLRVWGSQNTHSFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RTQRLPAQGHLPSVAHLEDFQGLTI----P-----RGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPMDGQ

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2611)

TGGQAKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRLGDL---GA---
----------------------------------------------MEPWALPAWQHWTQ
---GQGCKPGDASPSIAGTP-TALQVKGLRFE------ESSK----PEGAHSPGPVGNTD
PEATETGLPKLGQQAESPG-----------YSCS--GLEEE---------EAQ--A---Y
-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLSL-------V--GKE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SPGPTAPSR------------V
GAPA--PGAPGE----A----VLQDDVESPQVVLREP--EKQQRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENSELKGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPHCCCSI---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------TTLTGIPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PESHSGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLSTLPRELA--DSSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRHITVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLRT-GPL-HVSVQALTSKGS------------SDPLRCCLAVGAGAGVVPSQ
LRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESSDSIPAPVAPALA-SACQPARMSCLS-----PRPSPEVRTPLASVSPGLGDTSFP--
---LRHPVPHGT-------QDFS----ASLSIEMS---KGPQE-EP--PVPCSQE-----
------------------EAGAAVRSISEEKRAIEPTLGQEGPEPVAPSLAKQEVECTSG
D-AGPVPCS---TQGELTQK---KPSIEACHGGDLDSGLKLRSEKEDMS--ELGVHLVNS
LVDHSRNSDLSDIQEEEEEE-------EEEEEELGSRPCSSQKQVA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQRLCSKKLF-SIPEEEEEE---------EE
EEGLE-KPGPSRTSQDPSQPELALLG-PGCDSSQPQ----GPGLCPLS------------
-PELSGVR---EHLEDVLGV---VGGN-GRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQASARPV----PPRERGSLPVIEGTRVGQEPGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----SINSSCYPTDGEAWGTAAVGRPRGP----------------------
---PKVNPGPNAYLR--LPAWEKGEPERRGRSAIGRT------KEPPSRAT-ETGESRG-
QDNSGRRGPQR----RG--ARVPRSGTTELAP----PRSPQ-EAPPHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFKEGQLLKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLPPNVLTEAS--GNGPSVYSSAH-TPGPPPKPRRSKKVELEG--
-P----TQLCPGPPKL----I-HSAAQKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPESGS------L--ESG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGWSSPAAAVLENQRRELKKLRAELEAERAGWRAERRRFAAR
ERQLREEAERERRQLADHLRSKWEAQRSQELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHQERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSRG-SCH-APKPA-CQLGSP--DSLSAEVG--------VRSRSLDLVSS---
---ACSSSPDGLLS----T--HTSSLDCLAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPQGGEGSESQPCE-VLT--P
SPPGLGHQELIKLDWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTELAWRLADRARKL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP----CTQ------DLDRLQR
ESQREVLRLQRQLMLQQGN-GGA--WPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGAQEAPARRRGQEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASALIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH---
---EIQVLQCRPGHPP-EQPWETSQMPES---------QVKGSRRP------KFQARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSMSLALEMGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PN--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGVVD---RGLC-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQSL------------SRPLLG---TKGVLRMAPMQ
LHLQNVTATSANITWAYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHCRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVP----KVSVRTMSLC
GESLDSVPAQIPEDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVIFPVCP-------QK---LALAPLSAKAS----------SHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPS-VSEQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KPAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILKE-----
---EQEALCLDL--------------WGTERREERREPEPHSR------------Q-GQ-
ALGVKRECQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTRTNTPARVFVALSD
YNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

-------PDGTTQGCIKHPGCGAPPIALNRKG--HAGR----LAAAXXXXXXXDAALRVQ
ARQLREAAERERQQLVDHLRSKWEAQHDRELRQLQEDMLREREAEIRQLLRWKEAEMRQL
RQLLHRERDGVMRQARELQRQLAEELVNRGYCGRAGAP---------DVA-AAQCRCRLQ
EVLAQLRWDTDGEQASRIRHLQAALDVERRLFLKYILQHFRWHPALPVSPDP---QAVHS
SEEPPLHTAGN-SPG-PPKSV-CKLESLNTDSLSAGIR--------LRSRSLDVVPA---
---RCSSSPDSLLH----TP-RSCSLDSLAPA-RSRYLDS-T-LSCPKA-PESKKPAS-W
PDTPILGSSSPPPPLL----------PPPPPTSKHRRPSDPL-GEDSGSQPCE-ALT--L
SPPDLDYQELVKQNSELSEALQVLARRCSGLWEENVQLWRAGFQDKSDEKVKRLKVKHAE
LAGLARRLEDRARKL-QETNLRAVSAPVPG------ESRAGLELC-QAFARQRARDLSEQ
ASELLAKDKQIEELRLEYHLLQARVASGMNSVPHPGGGAA----QAQWLNI-SELDRLQR
ESQREVLRLQRQLTMQQST-GCAR--AEA-------------------------------
------------------------------DGESAPFEEA-RRQVQALELELGA------
----QAAAARRRGEEGEAQLRAALREEAWLAQKNARLQAQA--DWTRKVAAENSDVRGQL
G--CACQERDAAGMLEE--QLLQQAA----------RRQDKQQQLQHDLQKALRDLQ--A
AREEMLALQCQTGYLP-QESREAPQVPEA---------QVRDSGRT------KFQLAPEE
QAASQPSADKQGN--------------------QEASQ------------LESPIAIREP
ASDPQV--------------PDRVP--ASGPLDSRSLAKKTSSQS--NSPS---------
---------E-LESIWTTVP-SCPPLDMDTASEVEDLEPDGVSSTLEARS----------
-SEA-PLTPKLKIFLARYSYNPFKGPNEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPFTAGDYVYVLGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSDILGRQSPKSP----DFS-------------PT--RLL
GRHS--------------KFL-KE---------DTGHSLL--P-----------------
----------------------------------GKAQGAMD---KGTC-QMVRAGSKTE
V-AIEISDAKREEDSWLGSLQYGEEKGF------------SRPLLG---ATGAFGMAPMQ
LHLQSVAATSAKITWVYSSSNHPHMVYLNDQEHALTPAGVCCYTFHSLHPSTRYWARVE-
---VQLPWDLLQVHWETTSSTITFDTPLAGPPHPPLDVLVER-HASPGSLVVSWLPVTIH
SAGSSNGVQVTGYAVYADGFKVAEVAD---ATAGSTLLEFSQLHLPLMCQNVSVRTMSLF
GESLDSVPAQIPHDCFTC-HQLPETSSFSYT--------------------CGDLSTC--
----RVTVPVHP-------QR---LALAPLSAKAS----------PHTPGSCRE------
----PQVEF--------LEAF--------------PEEPSRRQSPM-CNLSSEGECASVG
S------G-------------------------SQPQGPIGAQE----------------
------------------------------------------------------------
-------------------VCRKDLLFQKSSPNHRPPL-LSGQSRGEEN---CYW-H---
-------MGA---RKSHASGVV-H-LF---------------------------------
---PESGLEKQPYQE---------------------------------------------
--------KAAF------------EKVLRQKQ------------------------DTDV
FA-----------------------PPQLDT-SQP---YVSDFH------NI--------
-LQEEEAVHVNL--------------WGPERREQRKEFRTQNG------------S-CQ-
ALGSKRECQLLEPSP---------------------------------------------
-------------------AHCPAPSSKVIKM----FRGGPSPLGTEVDTLARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPLVMSANPKVAEEELAFQKGQLLRVWGSQDPCGFYHGECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2509)

VKVGT
EQAD--GMWHLPAQGHLSSVAHLDDFGGLTS----P-----QGSFPMPQ-----------
-----------------GNPWRS--PLWTPTTMMTALDYDPKDGRAGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QVKDKLSLRAGD
MVMVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHLPLHGK------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPPPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGGEPGDIAPSIADTP-AALQVREVS--------------SQPQGAQNLGPVVGTD
PEGAEAGFISLKRQAESSG-----------RDCS--RIEDE---------EVQ--A---F
PKAMLNTGFGDQPNLELLRALGELQQRCAILKEENQMLRNSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVGAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQQECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQGP---PPPPQ---------LPGLAAPCR------------A
GARK--PVAPGE----A----TPQENVHSPPVVIGDP--KKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKEAQNENARLVEENSRLSGRA--TKKEQVEWENVELRGQL
L--GVTQERDSAVRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPQPSCCCST---PQHCRG---S-GPKDLDLH
LGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-V-----------
-TEGNPGGSRIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPLELA--DLSHS-------------SGPELSF
LSRGGGGSSSGGQSSGGHSQPRPEEE---NAGEELSLSPP---------PEGLGAL-SVP
YPRHLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARARIVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPPEGAWEPGWERPEHRASTLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVTVRTMSPH
GESADSIPAPVAPALA-SACLSAGVTCPS-----PQPSPEARTPLAVASPGPGDPSCP--
---LWCPAPCGG-------PEPPGGPPASLTREMP---KGAQE-EP--AAPCFQ------
-----------------EEAGAAVLGASEEKRAGEATTGKGGPGPAAPCRATKEAEWTIG
E-AGPMVYP---MQGVPTLR---TPSTEACHGADPG--TKARAEREDTA--ELGVHLANP
VVDHGRNSDLSDIQEEEEE--------EEEEDELGSRPCSFQQQVA---GGSSRESGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-IIPEEEEEEDGEE-------
TEEQG-KPGAVCSSQDPSPSEPPSPG-LGCDSGQPP----GLGLCPLS------------
-PEPSRAR---DHLEDMHGL---VGGN-SRRRGSGS-----------PEKPPSRRRP--P
DPREHCSRLLSNG-SSQASAR----PAPSRDRSNLPVIEGIRGGLEAGGKGRPGTS----
-------------R-RCSRGRA----PESGL-ASCLSPKGSEIS------IEYDSED-DQ
DVGS-GGI-----SITSSCYPADGEPWATAPVGRPRGP----------------------
---LKVNLGPSPYPH--LPAWEKGEPERRGRSVTSRA------KEPPSRAA-ETGEARG-
QDSPGQKGPQR----RG--PRVPRLSTTEQ----APPRSPP-ETLAHHDLPIRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGECGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PTG----RQLLFQRGYLSLDVVTEGT--GNSPFVYSTAH-TPGPPPKPRRSKKAELEG--
-L----SQPCPGPPEP----V-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPKPEVGS------PSRELMTIPRP
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPATAVLEEQRRELEKLRAELEGERARGRSERRRFATQ
TRQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAEMRQL
QQLLHQERDVVLRQARELQRQLAQELVNRGYCSRSGAS---------ETS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPADP---QATHS
LEEPPLEAQSN-TGG-TPKPA-RRLGSL--ESLNTGVR----------------------
-----VHSPNDLLP----T--RAGSLESLATA-HSCSLDN-T-LNCSQA-SESEVRAP-A
TSSSIPDTSSPQPPPQ----------LPS----IHRKPNDLQ-KESSENKPCE-AST--S
SPPGLDYHELVRQNSELAEALQVLVRRCCDLREENLHLRRTGFSEEAGEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLRAMSAPVPG------ESLEGLNLS-QVFTCQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQARIAADLGSSSHPEEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAS-AW--ADA-------------------------------
------------------------------GRPSTPSEIT-RHQVQALERELGLQRRECE
ELSVQAAAAERRYEETEAQLQAALHKGARLSEENARLQALA--NWMKKMADENSNVSRQQ
SHTRQRQELEATSLLAE--QLLQQEG----------YAQDRRQQLQRYKNKALSDLR--T
SGKEMQGLQFQPGHPS-ET-SETTQASES---------QARDSRRP------TFKTKSEE
RVLPLPTRDIQ-P-------------------PACLSQ------------QENPVILEEP
AAAPQV--------------SDRNP--TSQSLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSMSTPLEMRS----------
-LEA-PIIPKLKLFLARSS

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1159)

YNPFEGPSEHCQGKLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSNLV---EPISGSPILSHLFLKSP----DVG-------------PT--ALP
AGHS--------------KVL-------------KKGSLL--P-----------------
----------------------------------GEAQ---E---RGLC-QVGRVDSKAD
M-AAESLKTKT-EACWLGLKSSLEEQSF------------SRPLLE---AKGAFCLAPME
LQLQNVTATSATITWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTCYRVRVG-
---VQLPRDLLQVLWETMSSTLTFDTPLAGPPDPPLDVLVEHH-ASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLQVPLSCQKVSVRTMSLY
GESLDSVPAQIPEDFFSC-CPFLGAPPFNYT--------------------DGNP-----
-------FPVCH-------QK---LIQASLGAKSS----------PRGPGSCGE------
----TQAKF--------LEAF--------------PEEHPRKHLSL-SSLSSDG------
T------N-------------------------SQAQGPSEAWK----------------
------------------------------------------------------------
-------------------GYEKDLSFQKSPQNHKPPL-LFGQSGVEEG---HAP-H---
-------ICI---SGSPAPGFV-H-LS---------------------------------
---SEIGPGKIRCWE---------------------------------------------
--------KPGL------------EKALLQNQ------------------------YAPM
VP-----------------------PHQQGS-SQC---QPADFH------HVF-------
--EEKEALCLDS--------------RGTEKPEQRKNKS-QNG------------P-RQG
TPGSKRECS---------------------------------------------------
-------------------VLCPAPTNKVIKM----TSGSPDQLETDANSAVRVFLALFD
HSPLVISVNSEA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2395)

AEEELAFQKGQLLRVRGSLDLHGFYHGECNGHLGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2494)

EVEVGA
QQTD--GRWHLPAQGHLLSETQHEDLEGLTN----S-----QGSY-MPQ-----------
-----------------GNSRTP--TLWTPKTM

PF07653 // ENSGT00390000017228_1_Domain_5 (2494, 2612)

VATLDYDPRDGRAGVQAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSLPSLGDP---GN---
----------------------------------------------MEPWALPAWQSWTP
---DLGGDAGGASPSMAGTP-ADLRVGELRPE------ESSE----PEGARSLGPVGGME
PGRTGTGLPSPARGALSSG-----------PGCQ--RLEDP---------EAE--AGAVS
LPGKLKMGFGDRPNLELLRTVGELQQRCAILKEENQMLRKNSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---SPPR---------PPGPSVSAR------------A
GAPA--PGAPGE----A----TPQEDVENPAVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KREEVRRLQQAQAEAQ-REHEGAVQLLEVGSSCVSAQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSAPGVRPPPPCCCST---PQPCRG---S-SPKDLDLP
PASP-GRCTPKSSEPAS---------ATLAGVSRRTPAKRAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADNVSLLPA-V-----------
-AEGDRGGARVQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYVYIYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLASLPPELA--DLSHS-------------SGPELSF
LSGSGGGSSSGGQSSGGRSQPRPEDE---AAGEAPSPSPP---------PEGLGEPPAVP
YPRRLAILKQLAHSVVLA---WEPPP---ERVELSGYHVCVN---GELR-QALGSGAPPT
A-VLENLDLQA-GPL-WVSVQALTSRGG------------SDPLRCCLLLGAQAGVAPSQ
LRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAVYADGQKIMEVAS---PTAGSVLVELAQLQLLQACRAVAVRTMSPH
GESADSLPAPIAPALA-EASWPARVPCAC-----PRPGPEVRPPLAPASPGPGDPSSP--
---LRCPDPRGP-------QEAPGAPTASPPRETA---EGSSK-EP--PAPVSQ------
-----------------EQAGAAVLGAPGDRKATEPALEDCVPGPATSSMAKEDAEQTTG
E-ARLARGT---TQGTLAQR---LPCVQACRGGDAGSGLRPRAE-ED--AAELGVHPGNS
LVDQGRNSDLSDIQEEEEEEE------EEEEEEMGVRTCSFPKQVA---GHSIGGQGAKP
Q-PD------PFCETDSDEEILEQILEPPLQHFRSKKLF-SIPEEEEEEEEEE-------
-EEEK-GPGAGSASRDPGPPARLPPG-LGCDGARPR----GPGLCASS------------
-PQPCRAG---DRLEDPLGL---VSGG-SWRKGSGS-----------PEKPPGRRRS--P
DPREHCSRLLSNGSG--GSQAPGRAPGPARERGGPAAAEGARAPPDAGGRARPAPS----
-------------R-TCPRGRAPEPEPEPGL-ASCLSPKCLEIS------IEYDSED-EQ
ETGG-GDM-----SITSSGCLGDGEAWGAAPVGRPRAP----------------------
---PKAGSGPHSYPY--SPAWEKGEPERRGRSATGRA------KEPPPRAA-ESGEPRG-
LDSPGQSSSKR----RK--GWAPRPGSTEL----APLRSPPEASLALRDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEAGGRWGHIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2496)

VAVDS
PAG----TQQLLRQGRLSPEALAEGS--GNGLFVYSTAH-TAGPPPKPRRS---KKGGPE
SS----SPPPPGPPPL----A-SSASLKAPHSMVA

PF14604 // ENSGT00390000017228_1_Domain_5 (2496, 2615)

AFDYNPRESSPNMDVEAELPFRAGD
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------SDREPG-AAPS
EGQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PASQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILAEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELQ-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSQGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EETGAAVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGAMAQQ---APNTEACQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRSSDLSDIQEEEEEEE----VEEEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPIIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDIILEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----VQPCPGPPKL----V-PSTELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPVPQTSQGG------LSQSRA-GGWA
RNPQE-VC----WNGTGHLPGQWFWPQ---------------------------------
--------------------------------LFPRGIRV------------EG------
---------QS------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPQLGDP---RA---
----------------------------------------------MEPWALPAWPSWTP
---GQGSEPGGATPSIADTP-AALLGGEQRPE------ESSE----PEGAQSPGATGGID
PEGTKTGLPSLRHQAASSR-----------PSCP--RLDDE---------EVE--A---F
PKGKLDMGFGDRPNLELLRALGELQQRCAVLKEENQMLRKSGFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPVPRP-------GAGLELCRKALAHQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRLVARTG---PG-----------PPGAAVRPP---RLQVPA----
--PI--PG-HFQ----A----TPQEDVENPPAILGEP--ERQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLEGLEQVLKHMREAAQRRRQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLEQS-TLDSMQVRVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGYSTLGEHPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATVTGVARRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLSA-A-----------
-PEGSRGGARI

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFLARYSYNPFEGPNENPEAELPLTAGEYIYIHGNMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPGPEDE---AAGNELSPSPQ---------PEGLGGPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRSLVVLRQLAHSVVLA---WEPPP---ERVELRGYHICVN---GELR-QALGPGVPPK
A-VLENLDLRA-GPL-RISVQALTSQGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDPLRCCLVVGTRAGVLPSQ
LRVHRLTATSAEITWVPGNSNLVHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPPESWDPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAVYADGQKIMEVAS---PTAGSMLVELSQLRLLQVCREVAVRTMSPH
GESADSIPAPVPPALV-AACPPATVSCPS-----PRPGSEARPPLAPASPGPGDPSSP--
---LRRPDPCGT-------REPPGGPPAGET---P---KGSHE-EP--PAPCAQ------
-----------------EEAGAAVLGASEDVKASEPSAAERAPDPAASPLAKEE------
--ALPVPCS---AQGALGRQ---VPCAEGCRGGDPGSGLRPRAEREDTA--ELGGRLVNS
LVDHGRNSDLSDIQEEEE----------DEEVELGSRTCSFQKQVV---DHSIRENGAKP
QPHQ----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEEDE-E---Q
EEDEE-RPGAGCSFRDPGPPEPAALG-LGCDSGQPR----GPGPCPLS------------
-PEPCRAG---DRLEDMPGL---AGGS-SRRRGSGS-----------PEKPPNRRRS--P
DPREHCSRLLSNG-GPQASGR----PGPTRERGSPPVGEGTKGVPEAGGRGRPPPF----
-------------R-RCSRGRA----PESSL-A---TPKCLEIS------IEYDSED-EL
EAGS-GGI-----SITSSCYLGDGEAWGTAPIGRSRGP----------------------
---LKANSGPHPYPC--LSAWEKGEPERRSRSATGRA------KEPPSRAT-ETGEPRE-
KDISGRRGPSR----RG--VQVPRACATEL----APLRSPPEEALLYPDLPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRMGYIPCNMVVE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVAS
PAE----RQQLLQRGYLSPDVLTEGSGSGNGPSVSSTAR-TAGPPPKPRRSKKAEAESPA
-P----ARPCAGHLQH----V-PSAGLKSP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RTMVAAFDYNPRESSPNMDVEAELPFRAGD
IITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEASS------SDREPR-TPQP
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEPLTSLPRPGDP---GA---
----------------------------------------------MESWALPAWPSCTP
---DQGGQPGAAD------SPAARQVGEWRPK------EGSE----PEADPSPQPVEGTG
SEEALAGLPLPGRPADSPG-----------PGHP--KPEDK---------TVE--A---F
PTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-------X--XXX----XXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX----------------XXXXXXXXX-------XXXXXX
XXXXX-XXXXXX----A----RPEEDVDIPQVIPGQPEPEKLQEVQQLXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLES--TLDSMQARVRELEEQCRSQTERFSLLARE
LQAFRLHPGPLDLL---SSALGGSAFGDRPPPPCCCST---PQPCRG---S-GSKDLDLP
PGSP-ERCTPKSSESAP---------AALAGAERRV-AKKPESLS--NSSR---------
-----------SESAHNSA-KSCPTPEVDTASEVEELEADSVPLFPA-------------
---------------VPERYN

PF07653 // ENSGT00390000017228_1_Domain_1 (1102, 1159)

PFEGPNENPEAELPLTAGEYIYVYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLHSVPPELT--DLSHS-------------SGPELSF
LSWAGGGGSSRGAQSSGECSPPLEE----HVGDELCLSSA---------LDGLDKPPAXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXX-XXXXXXXXXX
X-XXXXXXXXX-XXX-XXXXXXXXXXXX------------XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
X-XXXX-X---X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLWKLSQMQRLLVCQEVAVRTMSPH
GESTDSIPAPVGPALP-LACLPARVSCPS-----PRPGPEARPPIAPASPGPGDPASP--
---LPLTAPHGT-------QEPPGVPPASCPSEAS---TGPPE-EP--PVPFSQ------
-------------------EVAAVPGTLEERRVCEPTVGEQGPGPTAPGLTQEEAQPAPR
P-----------AQGALAQA---ALCMEA-NQGDTGSGLLTRAQKEDTA--ELGARLVSP
LVDHSRSSDLSDIQEEEEEEE----EEEEEGEKLGPRHCSFQKQVA--GDXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXXXXXXPVCSNELF-SIPRRKSDEEEAE-------
-----EKRGPGCSTRDTNLPDPASWLEPDCD-AQPR----GLAPHPSS------------
-PDPFGAG---DHLEDLPGL---AGGS-CWRRGGGP-----------VEKLPSRRRP--P
DPREHCSRILGNG-GLQSSGR----PGPTRERGATPGGEGTRAGAEVGGRARPAPS----
-------------R-KCPRGRP----LESGL-ASCLSPKCLEIS------IEYDSED-EQ
EVGV-RGI-----SVTGSCPPGEGESWGTAPAGQPRGT----------------------
---LKASAAPSPNPR--PPTWEKGEPEGRGRSATGRA------TEPASRAI-KMGEFRG-
QDGSGRRDPPR----RG--PRAFRPGCREL----APLRGSLEKVMAWQDLTVR

PF07653 // ENSGT00390000017228_1_Domain_3 (2334, 2396)

LFVALFD
YDPLSMSPNPDAGEEELPFREGQILKXXXXXXXXXXXXXXXGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VAVDS
PAG----RQQRLQRGYLSPDVLVEGS--GTGPFACAAAR-TAGPPPKPRRSKKAEVEG--
------PAPCPGPPRR-------SAGLKAPR

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2616)

AMVAAFD-NRRENSPNTDVEAELPFQAGD
VITVFGGMDDDRLYY---------------------------------------------
-------------------GELNGKWGLVPSNFLEGPRPEVGS------LDRERQDG---
--------------------------ASTTPEPQAWPNALNPGAASRTE-----------
-------------------LGEPQGPSEKIRGLLSKGKQL-RKLGSGKKE----------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLTLPGDP---GA---
----------------------------------------------MEPWALPAWQSWTQ
---VQGCKPEDAGPSIADSL-TALQARGPKSE------ESSE----PEGAQSPGPVGNTD
PEGAEAGLPRLRQQALSSG-----------CSCP--RLKDE---------EAQ--T---F
-QAKLNMGFRDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNLRVVSAPVPGS-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---RQPR---------PPGPTVPSR------------P
GAPA--PGAPGE----A----IPQDDVDSLLVFLGEP--KKQQRVQQLESELSKKRKKCE
SLEQEARKKQRQCEELELQLRAAQNENARLVEENSRLSGTA--TEKEQVEWENAELRGQL
L--GVTQERDKALQKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAAAK-REHEGAMQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPHCCCST---PQPCQA---S-GPKDTDLP
PGSP-GHCTPKSSELAL---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSISLLPA-A-----------
-PEGNSGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DLSHS-------------SGPELSF
LSGGGGGSSCGGQSSGGHSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELH-QALGPGAPPK
A-VLENLDLRA-GPF-HVSVQALTSRGS------------SDPLRCCLTVGAGTGVVPSQ
LQIHRLTATSAEITWVPSNSNLTHAIYLNGEERPPARPSTYWATFCHLRPGTLYQARVEA
QIPLRGTWEPGWERPEQCAATLQFTTLPAGPPDAPLDVQIEPG-PSAGILMISWLPVTID
AAGTSNGVRVTGYAIYADGQKMMEVAS---PTAGSVLVEISQLQLLQACREVTVRTMSPH
GESADSIPAPVAPALA-PVCQPAVMSCPS-----PRPSLEVRTPLAPASPGPGDPSSP--
---LRHPAPHGT-------QESP----ASLSVEMS---KGPQE-EP--PVPCSQE-----
------------------EAGAAMLDASEERRTSEPTLGQGGLGLVASSLAKQEVDWTSG
D-SGHKPCS---TQGALAQR---ALSTESCHGGDLGSGLGPGAEKEDTS--ELGVCLVNS
FVDHGRNSDLSDIQEEEEE--------EEEEEDIGSRAHSFQKQVA---GNSIRENGVKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEEE-------
-GEEE-KPGPCSSSQDPTRPELALLG-LGCESSQSQ----GPGLCPLS------------
-PEPSRAR---DHLEDMPGV---VGGS-SRRRGGGS-----------PEKPSSRKRP--L
DPGEHCSRLLGNG-GPQTSARPG----LPREKGVLPVIEGTRGGLEAGGRGRPGLS----
-------------R-RCPRGLA----PEASL-VSCLSPKCLEIS------IEYDSED-EQ
EVGS-GGI-----SLTSSCYPTDGEAWGTAPVGRPRGP----------------------
---LKFNSGPNPYVH--LPAWEKGEPEWRGRSAPGRT------KEPPSRAT-ETGEPRG-
RDNSGWRGPQR----RG--TRVPRPGATDMAS----PRSPP-EAPTHQDIPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYWGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
SAR----RQQLLQRGFLSPDVLTEGS--GNGPFVYPTAR-TTGPPPKPRRAKKAELEG--
-P----IQPCLGPPKL----I-PSAGLKASRL

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFKAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--EPG-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPRKLGCSSRAAAVLENQRRELEKLRTELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQTALEVERQLFLKYILEHFRRNPALSEPANP---QAVHC
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSIPGSQSLPPPPSPLRPPPP--------PSDHRKLSNQQGGEGSESQPCK-VVT--P
SLPGLGHQELIKLNWLLAKALRVLARRCSTLQEENQQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPVPG------ESCVDLELC-QAFARQRARDLSEQ
ASALLAKDKQIEDLRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAW--PEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALESELVQRRRECE
ELGAQAAAARLRGEDAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVCGQV
G--HACQERDAAGLMAE--QPLQQAA----------RGQDRQQQLQCDPQKALYDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSGRP------KFQARPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTMDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGP

PF07653 // ENSGT00390000017228_1_Domain_1 (1107, 1157)

NDHPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLG-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RELY-QMVKVGSKTE
V-ATEILYTKM-EACQLGLLQSTGKQGL------------SRSLLG---TKGVLCMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTLAGVSCYTFQGLCPGMRYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDWFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNTGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECLSSG
A------S-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLFFQKSPQHHRRPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDL--------------WGTERQEDRREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFCLSECNRQVGNIPGHPVAEMEVGT
EQTD--RTRRLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPRDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVYGPVDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHRH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWHSWTP
---GRGGEPSSATPSVADTPPAALQLQELRSE------ESSK----PKGDGSSRPVGGTD
PEGAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GTSLELCRKALARQRALDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPL-PPSW---------PPGPALQAR-AGAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGSLGDCPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGRRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PHPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPASSS---TQGALAQQ---APNTETCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRNSDLSDIEEEEEE--------EEEEEELGSRPCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEE-E---------E
DEEEE-KSGAGCSSRDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----LGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---LKANSGPKPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDGSGRRGPQK----RG--VRVLRPSTAEL----VPARSRS-ETLAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSADLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVY----HIPAPQTSDRG------IGKEPS-GSPE
EWNGSPPW----TVVLA-----PAVPQGHQSRGAG-PEPLS-------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPSPSGGGRALPKKPGSPGPAAPVLEEQRRELEKLRAELEAERARGRAERRRFAAK
ARQLREGAEQERQQLADHLRSKWEAQRVRELRQLQEAMLREREAEIRQLLRWKEAELRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCGRSGQP---------DLA-AAQCRCRLQ
EVLSQLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFHWLPAMTEAPDS---QPVRS
SEEPLPETARG-ARR-PPESA-CHLGSP--DSLSTGAR--------IRSRSLDLERS---
---ECSSFPEGLIA----T--RATSLDSLAPV-RSRSFDS-T-LNCPKA-PEFEERAS-L
PGTSIPGSPSPQ--------------PLPPPASSHRKPKDLRVGEGAQRESGR-ALT--P
LPLDLDYHELVKQNSELAEALQVLARRCSGLREENIQLRRAGFPDEAGEKVKRLKVKNAE
LSGLARRLEDRARKL-QETNLRALSAPVPG------ESRAGLELC-QAFARQRTRDLEEQ
ASALLAKDKQIEELRQECHLLKARVVSGPGGAPLLGGGTP----SAQWLNV-SDLDRLLR
ESQREVLRLQKQLTLQQGQ-CGAR--EEA-------------------------------
------------------------------RGQSAPCEEA-RRQVQALEHELCARRRECE
ELGAQAAAARRRGEETQKQLQAALREGAWLAEENARLQAQA--DWVQKVAAENSDVRGQL
G--RACQERDAAGLLAE--QLLQEAA----------QEQDRQRQLQHDLQKALLDLQ--V
AREEMQALQCQPYPAP-KEPPEATQAPES---------QIRGSRRP------KFRPRPED
QTLSQPGWVEPEK--------------------KEVTG------------PENPVVLGEP
DSTLQM--------------PARVP--DSQPPDSMPLTKKTSSKS--TSSS---------
---------E-MESAWATVP-SCSTLDLDTASEVDDLEPDSVTPAPGTEG----------
-FEA-PAAPK--LFLARYSYNPFEGPN

PF07653 // ENSGT00390000017228_1_Domain_1 (1108, 1157)

EQPEGELPLTAGHYVYVFGDMDEDGFYQGELED
GRRG--LVPSNLV---EQIPDNDILACLPAKPP----DPG-------------PS--LLP
ARQG--------------QAE-KE---------DTSCSLS--P-----------------
----------------------------------GKAQDAVD---RGSC-QIVRAGSETE
A-TVEILDDKT-KACRLGSLQSMGGPGF------------SRSLLG---ATGSLCVTHMQ
LHLQSVAATSAEITWVYSSSRHPHVVYLDGREHALTPAGVSCYTFQGLRPGTRYQARVE-
---VQLPWDLLHMHSETMSSTLTFATPLAGPPDPPLDVLVER-HTSPGLLMVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVAEVAS---ATAGSILLEFSQLQVPLMCPKISVRTMSLC
GESLDSVPAQIPEDCFIC-HQWPKTSPFGYT--------------------CGDPSAC--
----RVTFPVCP-------ER---VALAPLSGKAS----------PHAPGNCGD------
----PQADF--------LETL--------------PAELPR-SPPM-PSLSSEGEHCSLG
A------S-------------------------GQAQDPRETQE----------------
------------------------------------------------------------
-------------------VCRKDPIIQKNPQSHGPPL-PGVQSEAEEN---CHR-E---
-------AAT---SQRPAPALV-R-LS---------------------------------
---PTCGPEKELRPE---------------------------------------------
--------KV----------------PLRQKQ------------------------DAQV
FN-----------------------APQLGI-SQQ---YTSDCW------GPWEEEE---
EGGGEEAACLGP--------------WSTKKQKQTKELRNQSG------------R-GQ-
TLGGKRECQFHEASS---------------------------------------------
-------------------LLYPAPSSKVIRM----SRGGRVWPE----KEARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
HKPLATSANPKAAEEELTFQKGQLLRVWGPQGPDGFYCGECNGQVGNIPGHLVA

ENSGT00390000017228_1_Linker_3_5 (2395, 2498)

EVEVGP
EWTD--GRWPLPTS--RPPEGHLKDFGGLVG----P-----QGSFFRSQ-----------
-----------------GNSQRP--PPWTPKTMLAAL

PF07653 // ENSGT00390000017228_1_Domain_5 (2498, 2611)

DYDPRDRRAGGQAKGRLAMRAGD
VVTVYGLMDNEGFYY---------------------------------------------
-------------------GESGGNQGLVPAHLLDHLPIHEE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTEDSPTPLGGGRTSPKKPGSPGQAAAVLEEHRREVEKLRAELEEERARGRAERQRFTAE
ERGLREVAERKQQQLADHLRSKWEAQRFRELRQLQVEVQREREAEIRQLMRWKEAEMRQL
QQQLGRERDSMVRQARELQRQLALELVNRGYCSRTRAP---------EVP-AEQCHCRLQ
EVLRQLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGSPEP---QAANS
SEETRLETRRS-ARS-TPKRP-LRLGPP--DRLGTLVR----------------------
-----V---HCQLL----T--RAGSLDSLATV-RCCSVDS-A-LSCPQAFNDSEAPFS-S
TDTFVAGSPNSSPPR------------------AHRKPKDPR-GECSGNQSPE-SLM--P
SPPGPDYCALVKRNSELSKALQELTRRCSELLEENLQLRRGGGPNQEDEKMKRLKMKHTE
LAGLARRLEDRARKL-QETNLRALSAPVPG------ENHPGLELC-QAFASQRARDLSDQ
ASALLAKDKQIEELRRECHLLQARVATGVDSPSNPAGGVP----GSQWVNI-SDLDQLQR
ESQREVLRLQRQLTLQQ---GSAL--AKA-------------------------------
------------------------------DSQSAPCEES-RHQVQALERELDTLRHECE
ALGSKAAAAQRRGEEAEAQLQAALWKGAWLAEENVRLQAQA--HWVRKVAAENSDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------LEQNRQQQLQHDLQKALSDLQ--A
ARKEMQALQDQPGHPP-QQPQEATQ--------------ATGRGRQ------KFKPQTQD
YAPSQPS---KEQ------------------IPVCLTL------------QESPVALGEP
VSSHPV--------------SEGVP--ANQPLDSRHQTNKTSSQS--TSSS---------
---------E-VESIWATVP-SCLTLEMDTASEVDDLESDSVSLPLEAKD----------
-PGA-PSTSKLKIFQAKYS

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1157)

YNPFEGPNEHPEHELPLTAGDYVYVCGDMGEDGFYEGELED
GRQG--LVPSNLL---EQIPDNPNTSDLSPKSPESPNHLG-------------PT--ILP
VGQN--------------KAL-------------EEAYLL--L-----------------
----------------------------------GEGQESVN---RGLY-QMGREGPKTE
K-ATEILELKR-EACWLDSSQSRQEQSF------------STPPLR---TKGLSCVGPMQ
LHLQNVTATSAEITWVYSSSRHLHVVYLDDQEHALIPSGVSCYTFEGLHPGTQYQARVE-
---VKLPWDLQQVPWETMSSTITFNTPLAGPPDPPLDVLVEHH-TLPGFLVVSWIPVTID
SAGSSNGVQVTGYAVYADGLKVAEVSD---ATAGSTLLELSQLQVPLTCQKVSVRTMSLC
GESLDSVPAQIPEDCFTY-HALPGTPPFSNT--------------------CGDPS----
------SFGVYH-------QK---MALASLNTKAG----------PHNPGSCGE------
----PQAKF--------PEVL--------------PEEPLRRQPPS-SNLSSEE------
A------G-------------------------RQAPGSTEAQK----------------
------------------------------------------------------------
-------------------GCRKDLLFPKSPQNHRPLL-SSGQSVMEEN---QCE-H---
-------MGA---RRSSSPGFI-HHLS---------------------------------
---STCRPRKELCQE---------------------------------------------
--------KPAL------------EKALRRKQ------------------------DAQV
LT-----------------------LSQQGT-SQQ---YVADSC------NIL-------
--EEE--VCLDP--------------WYTEKREHREKPRSQSR------------K-QQ-
P-------A-----S---------------------------------------------
-------------------VLCPAQSSKIIKM----PSGGPAQLGPEANTPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPLAMSTNPKAAEEELAFQKGQLLRVWGSHDPRGFYHGECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2509)

VEVGT
GQPS--RRWHLPAQEHLPSVARLKDLEGFTS----S-----QSSFLSPQ-----------
-----------------GNSRRP--TLWTPKTMMVALDYDPRDRKAGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

RAKGKLALRVGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLIPAHLLDDLSVHRQ------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------NTKLLSALEDLRHRCSSLAEENSLLRRSCFPQA-EEKVKHLKRKNAE
LAVIAKRLEERARKL-QEANLKVVTAPMPLK-------GSSLELCKKAFARQRAKDLTEQ
ASALLAKDKQIEALQQECRELQAKL-L-------A--GKD----DPCCLNV-IEFDRLLR
ESQREVLRLQRQIALKNFKECLRSSK--M---------SSGSAMPSA-ATCPGPSNSC-L
K-------GA------P----RPKEALGDPALGERTC--RE-------EVELKKKRKKCE
NLEHEVRKKHKRCKELEIQLQEVQSENARLAEENLQLNEKA--GWAGQVESENADLKLQV
V--LVTKERDSVIQTNQ--GLQTKLENLEQVLKHMRNLAERRQQLEVEHKEALLVLQ--E
KQEEVRRLQQAQAEAR-REHEGAVQLLEC--LDWMQHARVKDLEDQCRSQTEQFSLLSQE
LQQFRLQTGKIDLL---TSTLVTSEL----PLALCSSA---PQPRWE---K-E--SDELE
L----SQRGLDTTVGSP---------AA--PTSAQKQSKKGESQS--SSSK---------
-----------SESMQNSP-KSCPTPEVDTASEMEELDVDSISLMPE-------------
--PGSQGPAKLQVFLARYSYNPFD

PF07653 // ENSGT00390000017228_1_Domain_1 (1105, 1157)

GPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLMMFLPPELN--DLTHS-------------SYQEKSL
VSASTS--------SGDKSEFSIE---------ESSISPLA--SRAEGDQEEPVSHTAVP
YPRKLTLIKQLARSIVVG---WEPPLLPAGCPDIQSYNIYVD---EELR-QNVKSGLQTK
A-VIEKLDLHS-RAY-RVSVQTVTEHGS------------SDKLRCTFFVGQDFGMAPTM
LKVRSVTATSAEITWLPCSSNYSHGVYLNGQECDVTKPGVYWYTFRNLQPSTQYVAKLEA
R-PMKSPWEEMPKGQEQDSAMIHFATPLAGTPDAPLDVQVEAG-PSPGILVISWLPVTID
AEGSSNGVRVTGYAVYADGQKVIEVTS---PTAGSVLVDLSQLQMFQVCREVSVRTMSQY
GESVDSVPA---------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------MPLVLGPGVLQCHR---
--------------------------------------GSEPPSPAREKGEQ---GA---
----------------------------------------------MEPQALPTWPGWGP
---SPGGVPGSTAPMWGDAL-VALEAEEMDPE----------------DTGSPGQMEDTP
SGGEGAVSPRANSLSSATQ-------LPESPGSIRRRLQC------------W--GTENP
SQTWLDSGGGVRPNMELLRALGEMQRQCAILKEENQQLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAHKL-QEANLLMVNAPMPRP-------GASLELARKVLASQRARDLSET
ASALLAKDKQIAHLQRECQELQARLSS-------E--GKE----GPQWLNV-WDFDRLLR
ESQQEVLRLQRQIALRNLQEVPPTGSPSP---------LDTRVL----------------
--PPA-PGAPGE----AVPLARSQDDVDLLPEGALLAEPESQQRVKQLELELGKKRKKWE
TLEHEVRKKQRRCEELELQLRKAQSENARLLEENSRLSGRA--SGKEEVESENVELRGRL
Q--GVTEERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLELEHEQARIGLQ--E
KQEEVLRLQQAQAQAK-REHEGAVQLLET--TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRTHPGPLDL---LSSTLGTSS-TELPPVPCCCST---PQPCRG---P-SPKDADLP
PGSP-RHGALRTPEAVS---------IAHSGAPRRA-SRKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPE-------------
-PEGVFRGAKLQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLMTSLPPELM--DLSHS-------------SGPELSF
LSAGGAG-SSGGQSSRGGSQARQEEERN-----ELS-------------PSPLLDPPAVP
YPRHLAVLKQLAHSVVLT---WEPPL---DGAEVQGYHVCVD---GKLH-QALGPGPPRK
A-VLEHPDLQS-GSC-CVSVQALTSQGS------------SDPLRCCLMVGAGAGVAPSQ
LRVHRLTATSAEITWVPSNSNFAHAVYLNGEECPPARPGTYWGTFCHLRPGTPYQARVEA
RPITLRPLEPSLEKLQNRAAVVHFTTLAAGPPDAPLDVQIEQG-PSSGILLISWLPVTID
AAGSSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVDLSQLQLLRECREVVVRTMSPH
GESVDSIPAHLPPALA-LAYPPAPVLRPSAASLLPSTSPEAKSLPCPASLSPRDSSPP--
---PQPHHPPGS-------RDIEGGLPSSPSKTAE---RLPQEDST--R-NSQQE-----
---EPGVP---------TAAVWAP-GGKRGQDTGPPLSGKEEEEEEA-VM----AEKGQG
E-SALTPSP---APGAPAEK---MSGIEP-GRGEISPGLRTRAEQRE-DTSDLGVRLTNS
LVDHGRSSDLSDIQEEEEEE----EEE--P----GAESFSL--TQH--GETNDRENGAKL
----------DSCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEDEMEEEK------
--KEEEKKGAEDSLACVHLPESQGMG---LHRSGSR--LWELRSPPSA------------
-PDSSLGR---DPPEELTPCQAGGSPLGSRRRGGGS-----------PEKLPARKRP--P
DPREHCSRLLGSS-GTQASGR----SGPSWDRGAPSSIEGVKCGTENSWKGWPGLS----
-------------R-RCSRGLA----PESGL-ASCFAPKCLEIS------IEYDSED-EQ
ESVGRGSS-----ISSSSVCPRDGEGRGSGPEGAPLGGRR--------------------
GA-PGASTAPSHCLR--LSNCEKGELERRGRSLNCRV------KEPSPRTP-EARELRG-
QDAAGQRGPSR----KG--SRPPRLSAPELAF----SRNQT-KEISPPNEPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAVEEELPFREGQLLKVCGEKDADGFYRGECGGRVGYVPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVGS
PVV----KRQLLQRGYLHPDSPKEGL--GNGSFPLLAPH-PAGPPPKPRRSKKGSSSQPD
----------------------VRASPSTPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNVDVEAELSFKAGD
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGVISGEDRKVVGPSKEKDPG-VLMA
ESQRMRKR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGELGGAAPRVADIPPAALQLQELRSE------ESSE----PKEAQRSRPLVGTD
SEGAEAGLPSLGQQASSFG-----------PTCL--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKAIARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPAPQAR-AGAPAPGA----
--PA--PGAPGE----A----TPQEDVDNLLVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDHQPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-TKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGSRGGSRIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WDLPP---ERVELHGFHISVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSQGS------------SDPLRCCLAVGARAGVVPRQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPQGPWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
AESADSIPAPITPALA-PASLSARVSCPS-----PRPGPEARAPLTSASPGPGDPSSP--
---LQHSAPLGT-------QEPPGAPPASPSRELP---KGVHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTATMSTLSEKDPGPAVPSLAEQEAEWTAG
E-ACPAPSS---AQGALASQ---GLNTEMCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHSRNSDLSDIQEEEEE--------EEEEEELGSRTCSFQKQVA---GNSNRENGAKS
---Q----PESLCETDSDEEILEQILELPLQQFCRKKLF-SIPEEEEE-----------E
EDEEE-KPGAGCSSRDPGQPEPALLG-LGCDSGQPR----GPGQCPLS------------
-PEPSRAG---DCLEDMI------GGS-SRRRGVGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERCGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGWA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGS----------------------
---PKANSGPKPYPR--LPAWEKGEQERRGRSATGRA------KEPLSRAT-ETGESRG-
QDGSGRRGPQK----RG--ARVPRPSIAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAR-TAGPPPKPRRSKKAESEG--
-P----GQPCPGPPKL----V-PSADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TFQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGSAAPSVADTPPAALQLQELRSE------ESSK----PKGAGSSRPVGGTD
PEGTEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--V---F
PKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPL-PPSR---------PPGPALQAR-AGAPA-------
------PGAPGE----A----SPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGTV--TEKEQVEWENEELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLES--TLDSMQARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGSLGDCPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-V-----------
-PEGSRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSS-GQSSGGRSQPRPEEE---DAVDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPL---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELCQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PQPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCPQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPASSS---TQGALAQQ---ALNTETCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEEEE------EEEKEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KPGAGCSSPDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPIIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDSSGRRGLQK----RG--VRVLRPSTAEL----VPARSPS-ETLAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYVPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
IITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPESGG------LDREPR-TSQT
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VLREREAEMRQLLRWKDAEMRQL
QQVLRRERDGVARQARELQRQLAEELLSRGYGGGRAGP-P-------EDA-GARCRCRLQ
EVLSQLRWETHGEQASRIRHLEAALDVERRLFLKYILEHFHWHPALPSAPDA---PL--P
LGEPTREAAAKARDGRSAGVR-ARSRSL--DRVPAA------------------------
----RARSPDSPLP----T--RASSLDSLAPAGPRPSLDG-S-PSHPRA-----PESS-S
PDASLSGSLRPLPPPP----------SPP--PSERQIPSHLREGEEAGSRPCE-ALS--P
PPPGPDHCELLRRNSELSEALQELARRRCGLREENVRLRRLGLPDEADEKAKRLKGKRAE
LTGLARRLEDRARKL-QEANLRAVSAPVPG------ESRPGLELC-QALAHQRARDLSEQ
ASALLAKDKQIEELRQERHLLRARVASGLG--PLPGEGAA----SAQWLSI-GDLDRLQR
ESQREVLRLQWQLTLQQA-AGGAR--AEA-------------------------------
------------------------------GGQSAPCEAA-RRQVRALERELSARRQECE
ELGAQAAAAQRRGREAEAQLQVALREGAWLAKENARLQAQA--DWTRKVAAENEDVRGQL
G--RACQQRDSASLLAE--QLLQQAA----------QRQDWQQQLQHDLQKVLCDLQ--A
ARDEMWALQCQPAHPP-QDNRGTEP-----------------------------QLGPAN
PASPVPSRDKQGR--------------------KEDLL------------LESPAALGQP
AWAPQA--------------PDS----SGQPLDSRPQPQRTGSQS--NSSS---------
---------E-VESAWATVP-SCPILDADTGSEAEDLEPDSLPSTLEAGD----------
-LEVSVATPKLKIFLARYSYNPFEEPSEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPLTPGDHVYIFSDMDEDGFYEGALAD
GRQG--LVPSNLV---EQIPDGDIRGCLPTESP----DRG-------------PT--WLP
AARQ--------------GQAWKD---------DPSPGFL--P-----------------
----------------------------------GQAQAAVD---RGPC-PVARVGSRME
V-ATEVSDTKT-EAGRLGSQESRDRQGS------------ANAPPG---NNRSPRMAPTH
LHLRSVAATSAEVAWVGGS--HAHAVYLDGREHALTSMGVSSYTFRHLQPGTRYQVRVE-
---VRPPGDSLQACREKTSSAVTFETPLAGPPHPPLDVLVERH-PSPGLLVVSWLPVTID
AAGSSNGVPVTGYAVYADGLKVADVAE---ATAGSTLLELSQLPWPETCQKISVRTTSLC
GESLDSVPAQIPHDCFTC-LHWPEMSPFGYT--------------------CRDPSAI--
----SGSFPVCP-------RR---LGPTPLSAKAC----------PHAPRSCEE------
----PRARC--------LEAF--------------PEEPPRRWSPE-PKLISEGGGPSSG
S------G-------------------------SQAQGPAEARK----------------
------------------------------------------------------------
-------------------PPRKDQLFEKRPWNHRPPL-PRGQPGREGT---QDR-R---
-------MLT---VPTPAAGVS-H-LS---------------------------------
---PEPAPGEELRQE---------------------------------------------
--------KPAS------------GKVLRQKA------------------------DALV
ST-----------------------PPELGS-SQQ---SASVFS------GAR-------
--QE------DG--------------RGAEGRERRRALRGRST------------Q-GQ-
ALGARAGGRLRGPSS---------------------------------------------
-------------------APCPARRSKALGT----PRGAAPPPGTRVGPRAGIFVTLPN
YEPLAVSATSEAAGGELALQKGQPQSAGGSQDPHGFCRGECSGPVGSITSHLVAEVDAGT
ECTDGHGRWHLPG--------HLDDSEGLTG----P-----QGSSPLPQ-----------
-----------------GSPGRPSSSLWAPKTMMAALDYDPQDWLARG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2611)

PVKGQLSLRAGD
VVTVHGPVDDKGFYS---------------------------------------------
-------------------GEVGGHRGLVPAHLLGHMSLQEH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGWSSPAAAVLENQRRELKKLRAELEAERAGWRAERRRFAAR
ERQLREEAERERRQLADHLRSKWEAQRSQELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHQERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSRG-SCH-APKPA-CQLGSP--DSLSAEVG--------VRSRSLDLVSS---
---ACSSSPDGLLS----T--HTSSLDCLAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPQGGEGSESQPCE-VLT--P
SPPGLGHQELIKLDWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTELARRLADRARKL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLMLQQGN-GGA--WPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGAQAAPARRRGQEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASGLIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH--A
SWKEIQAPQCRPGHPP-EQPWETSQMLES---------QVKGSRRP------KFHARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----EKTSSQS--NSS----------
---------S-EGSMWATVP-SSPTLDRDTASEVDDLEPDSMSLALEMGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNFV---QQIPDSYIPGCLPAKSP----DLG-------------PN--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGVVD---RGLC-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRPLLG---TKGVLCMAPMQ
LHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTVTFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQDHRPPS-VSEQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KAAL------------ERVLQQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILKE-----
---EQEALCLDL--------------WGTERREERREPEPHSR------------Q-GQ-
ALGVKRGCQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTGTNTPARVFVALSD
YNPLVMSAILKAAEEELVFQKRQLLRVWGSQDTHDFYLSACNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSPAQGHLPSVAHLEDFQGLTI----P-----QGSTLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHGGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRAELEAERARGRAERRRFGAQ
ARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHQERDVVVRQARELQRQLAQELVNRGYCGRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDSERQLFLKYILEHFRWQPALSEPADP---QVVHS
LDEPPIGAQSN-TGG-TQKPA-RRLGSL--ESLRTGAR----------------------
-----VSSPDDLLP----T--RASSLESLATA-HPCSLDS-T-RSCPRA-PESELGAS-S
TSASRPGTSSPPPPPQ----------LPS----KHKKPSDLK-GESSENKPCE-APT--L
SPPGQDYHELVKQNSELAEALQVLVRRCCDLREENLQLRCTGFSNETDEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLQAVSAPVPG------ESLESLDLG-QVFAHQRTQDPSEQ
ADALQAKDLQIEALRRECHLLQAHIAADLGSSSLPGEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AR--AEA-------------------------------
------------------------------GSLSSPSEIA-RYEVQALEEKLGAQRRECE
ELSAQAAAAERRYEEAEAQLQAALHKGARLSEENARLQALA--SWVKKMADENSNVPRQQ
NHARQRQELEATSLLAE--QLLQQAG----------YVQDGWQQLQYYQNKAPSDLL--A
SGKEIQGLQCQPGHPL-ET-SETTQASES---------QARDSRRP------KFKPKSEE
HALSLPTRDIE-P-------------------PVCLSQ------------QENSVTLGEP
AGIPQV--------------SEKNS--ISQPLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSVSSPLEMRS----------
-SEA-PTTPKLRIFLAR

PF07653 // ENSGT00390000017228_1_Domain_1 (1098, 1157)

CSYNPFEGSKEHSQGQLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSNLV---EQISGSPILNHLLPKSP----DIC-------------PT--ALP
PEQT--------------KAL-------------KKGSLS--L-----------------
----------------------------------GEFKGSLE---TGLC-QVRRTDSKTD
V-AIEILETKT-EACWLGLKPSMEEQSV------------SRPLLE---AKGVFCLAPMQ
LQLQNVTATSATITWASGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLHPGTRYRVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHH-ASPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLRVPLACQKVSVRTMSLY
GESLDSVPAQIPEDCFSC-YPFLDTFPFSYM--------------------DGDP-----
-------LT-CR-------V-------ISLSTKTS----------PHTPGSCGE------
----PQVKF--------VEAF--------------PKDPTRKHSPI-SNLISER------
A------D-------------------------NQVQGPAETWK----------------
------------------------------------------------------------
-------------------DYEKGLSLQESPQNLKPPL-PFGQSGVEEG---HSP-H---
-------MCI---NGCPAPGFI-H-LS---------------------------------
---PEIGPRKVLRWE---------------------------------------------
--------KPGL------------EKA-LQKQ------------------------YDQT
LP-----------------------PHQQGS-SQL---PTADFH------HVR-------
--EEKAAVCLDS--------------RCTEKLGQRKNKF-QSG------------Q-TQE
TPGGKRE-----------------------------------------------------
-------------------LLCPVPTSKVIKM----ASGVPEKPETEANNPVRLFVALFD
HSPLVMPVNAK

PF07653 // ENSGT00390000017228_1_Domain_3 (2352, 2395)

SPEEELVFQKGQLLRVWGSQDPHGFYHGECNGRVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2512)

EVEVGT
DQTD--KRQPLPAQGHLHSEAQHEDLEGLTN----S-----QGSL-MSQ-----------
-----------------GNSRTP--TLWTPKTMVAALDYDPRDGRVGVRAK

PF07653 // ENSGT00390000017228_1_Domain_5 (2512, 2612)

GKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRAELEGERARGRSERRRFATQ
TRQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAEMRQL
QQLLHQERDVVLRQARELQRQLAQELVNRGYCSRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPADP---QATHS
LEEPPLEAQSN-TGG-TPKPA-RRLGSL--ESLNTGVR----------------------
-----VHSPNDLLP----T--RAGSLESLATA-HSCSLDN-T-LNCSQA-SESEVRAP-A
TSASIPDTSSPQPPPQ----------LPS----IHRKPNDLQ-KESSENKPCE-AST--S
SPPGLDYQELVRQNSELAEALQVLVRRCCDLREENLHLRRKGFSEEAGEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLRAMSAPVPG------ESLEGLDLS-QVFTCQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQARIAADLGSSSHPEEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AW--ADA-------------------------------
------------------------------GRPSTPSEIT-RHQVQALERELGLQRRECE
ELSVQAAAAERRYEETEAQLQAALHKGARLSEENARLQALA--NWMKKMADENSNVSRQQ
SHTRQRQELEATSLLAE--QLLQQEG----------YAQDRRQQLQHYKNKALSDLR--T
SGKEMQGLQFQPGHPS-ET-SETTQASES---------QARDSGRP------TFKTKSEE
RVLPLPTRDIQ-P-------------------PACLSQ------------QENPVIVEEP
AAGPQV--------------SDRNS--TSQSLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSMSTPLEMRS----------
-LEA-PIIPKLKLFLARSS

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1159)

YNPFEGPSEHCQGKLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSNLV---EPISGSPILNHLFLKSP----DIG-------------PT--ALP
AGHS--------------KVL-------------KKGSLL--L-----------------
----------------------------------GEVQ---E---RGLC-QVGRVDSKTD
M-AAESLKTKT-EACWLGLKSSLEEQSF------------SRPLLE---AKGAFCLAPME
LQLQNVTATSATITWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTCYRVRVG-
---VQLPRDLLQVLWETTSSTLTFDTPLAGPPDPPLDVLVEHH-ASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLQVPLSCQKVSVRTMSLY
GESLDSVPAQIPEDFFSC-CPFLGAPPFNYT--------------------DGNP-----
-------FPVCH-------QK---LVQASLGAKSS----------PRGPGNCGE------
----PQAKF--------LEAF--------------PEEHPRKHLSL-SSLSSDG------
T------N-------------------------SQAQGPTEAWK----------------
------------------------------------------------------------
-------------------GYEKDLSFQKSPQNHKPPL-LFGQSGVEEG---HAP-H---
-------ICI---SGSPAPGFV-H-LS---------------------------------
---SEIGHGKIRCWE---------------------------------------------
--------KPGL------------EKALLQNQ------------------------YAPM
VP-----------------------PHQQGS-SQC---QPADFH------HVF-------
--EEKEALCLDS--------------QGTEKPEQRKNKS-QNG------------Q-RQG
TPGSKRECS---------------------------------------------------
-------------------VLCPAPTNKVIKM----TSGSPDQLETDANNPVRVFLALFD
HSPLVISVNSEA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2395)

AEEELAFQKGQLLRVWGSLDLHGFYHGECNGHLGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2499)

EVEVGT
QQTD--GRWHLPAQGHLLSETQREDLEGLTN----S-----QGSY-MPQ-----------
-----------------GNSRTP--TLWTPKTMVAALD

PF07653 // ENSGT00390000017228_1_Domain_5 (2499, 2612)

YDPRDGRAGVQAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGNP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAVPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLES--TLDSMQARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPAPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------V---PSVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEEEE-----EEEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGWA----LEPGL-ASCLSPKCLEIS------IEYDSEE-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPEQRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSAELKTPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPAPQTSQGG------LSQSWA-GGWA
RNPQE-VW----WNGTGHLPGQWFWPQ---------------------------------
--------------------------------LFPRGIRV------------EG------
---------QS------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAATVLENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFRRNPSLSEPADP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PYTSIPGSQSLPPPPSPLRPPPP--------PSVPRKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCAGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKA--ENSEVRGQV
G--RACQERDAAGLMAE--QLLQQAA----------RGQDRQQQLQCDPQKALCDVH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAAGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERREPKPQSR------------Q-GQ-
ALGAKRECQLHKPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RMRRLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVFGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAATVLENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFRRNPSLSEPADP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PYTSIPGSQSLPPPPSPLRPPPP--------PSVHRKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCAGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--NWVRKA--ENSEVRGQV
G--RACQERDAAGLMAE--QLLQQAA----------RGQDRQQQLQCDPQKALCDVH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISDCLPAKSP----DLR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAAGFI-Q-LH---------------------------------
---TKCGSRKELCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERREPKPQSR------------Q-GQ-
ALGAKRECQLHKPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RMRRLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVFGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPGSPGPAAAVQEEQRRELEKLRAELEAERARRLAERRRFASQ
ARQLREAAERERQQLADHLRSKWEAQRFRELRQLQEDVQRQRETEIRQLLRWKEAELRQL
QQLLHRERDGVVRQARELQRQLAQELVNRGYCSRAGAP---------EVS-AAQCRCRLQ
DVLAQLRWDTDSEQAARIRHLQAALDMERQLFLKYILEHFRWQPALSGPPDS---QAVNP
SEEPLPGTASS-ARL-TPKPD-CRLASL--DGLSAR------------------------
------DRIHGLLP----T--RASSLDSLATE-RSCSLDS-T-LSFPKA-SETEARVS-L
TDASIRGSLSTPPPPL----------LPSLSLSVRRNPSDPR-EEISRKEPCA-ALT--P
SPLSLDYQDLVKQNSELAETLRVLARRCSGLQEENIQLRRSHFSDGAEEKVKRLKVKHAE
LTGLARRLEDRARKL-QETNLRAMSAPVPG------ESRSGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELQRECHLLQARVATDLNSVSDPGGGAP----CTQWLNI-SDLDRLQR
ESQREVLRLQRQLTLQQG-KSDKP--AEA-------------------------------
------------------------------GGQSALCEDA-RHQVQALERELGARRRECE
ELGAQAAAAQRRGEETAAQLQTALRKGAWLAEENARLQAQA--DWVRKVAAENSDVREQL
G--RACQERDAANLLAE--QLLQQAA----------REQDRQQQLQHDLQKALSDLQ--D
ARKEMQALQCSSEHPP-EQLRETTQTPES---------QGRGSGRA------KFKPGPED
HALSDPS---K-Q------------------LLVCLSQ------------QENP-VLGEP
SSVPQV--------------SDRVP--ASQLLDSRPQTKKTSSHSNSSSSS---------
---------E-VESMWATVP-SCLTLDMDTVSEVDDLEPDSVSPSLEVGS----------
-SET-PATPKLKIFLARYSYNPLEGPN

PF07653 // ENSGT00390000017228_1_Domain_1 (1108, 1157)

EQPDGELPLTAGDYVYIFGDMDDDGFYEGELED
GRRG--LVPSNLV---EQIPDSDILGCLSSKYP----DLG-------------PT--VLP
AGQS--------------RVS-------------EENSSL--S-----------------
----------------------------------GEAQGSVD---RVPC-QQGRVGSKTE
V-AVEILESKT-KACWLGSPHSVGEQGF------------SRPLLG---AKGVLCVAPMQ
LHLQNVTATSAEIAWVCSSNRHPHVVYLNDQEHALTPSGVSCYTFQGLHPSTRYQVRVE-
---VRLPWDLLQEHWETMSSTIIFNTPLAGPPDPPLDVLVEHH-TLPGFLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVAEVTD---ATAGSILLQFSQMQVPLTCQKVSVRTMSLY
GESMDSVPAQIPEDYFTC-NPLPETPSFSY------------------------TF----
------TFPVCH-------QK---LVLASPNTKAV----------PHTPGSCGE------
----PQTKS--------LEAF--------------PEEAPKRQSPV-SNLSSEG------
T------G-------------------------NKVQEPIETWK----------------
------------------------------------------------------------
-------------------KCRKDMSFQKNPQNHHRLPVPSDQSGLKEN---HYG-H---
-------MNT---SRSPVPGFS-H-PP---------------------------------
---PECGPRKELSQE---------------------------------------------
--------KAAF------------EKTLRQKQ------------------------NTQV
FI-----------------------PPQQRT-CQQ---YAADFH------DIF-------
--EEAAALCLDP--------------WCTKNQEQKKNLRPHSR------------R-GQ-
ALGDKRECH-----S---------------------------------------------
-------------------VLCPTPSSKIIKM----SRGGPTQLGTEANIPARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YNPLTMSANPEAAEKELTFQKGQLLRVWGCQDPHGFYHGECNGQVGNIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2508)

EVEVGT
EWTD--RRWHLPAQGHLPSVGHLADFERLTR----P-----QGSFLIPQ-----------
-----------------GNSKRP--TLWTPKTMMAALDYDPRNRRAG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

CRGKGKLALRAGD
MITVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDDLSIHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGSGRASPKKTGSPGPPAAVLEEQRRELEKLRAELEAERARGRAERRRSAAQ
ARQLRESAERERQQLADHLRSKWEARRFRELRQLQEEVQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAQELVNRGFCGRAGASSS-------EVA-AGQCHCRLQ
DVLAQLRWETDSEQAARIRHLQAALEVERQLFLKYILEHFRWQPVLPGPTDP---QALHP
SEDRSPETPSSVHQA-PEKPA-CRLRSL--ESLSAGGV--------R-------------
----CSSCPDDLLP----T--RASSLDSLATS-RSCSIDS-P-PNCPQA-SKSEVRAS-P
TIASIPDTPSHPPPP-------------S----AHRKRSTPR-EEDSEKEPCQ-ALN--P
SPPRLHYHELVTQNSELAEALQVLVRRCSVLREENMQLRRAGCSDEAEEKVKRLKVKHAE
LTCLARRLEDRARKL-QETNLRALSAPGPG------ESLAGLELC-QAFARQRAQDLSEQ
ASALLAKDKEIEELRRECHLLQARLATDLGGSSHPEEGAP----CKQWLNI-SDLDRLQR
ESQREVLRLQRQLTLQYCKGVAA-------------------------------------
------------------------------G-----GQSA-PCEVQALRRELGAQQLECK
RLSAQAAAARRRSEETEAQLEAALRKGAWLAEENARLHALA--DWVRKVANPNNDS--QL
S--HACQELEATGLLAQQPQLLQQAV----------CRQDGQQQLQYYPQKALSYL---Q
PGKEMQGLQCQPGHPS-EE-PGE--TTQG---------PATGSRKP------KFKSNSEE
HALSLPIRDIQ-P-------------------PIGLSL------------QDSQVALGKP
VSAPHV--------------SDRCP--SSQPLECRSQAKKTNSQS--DSSS---------
---------E-MESMWATVP-SCFSLDMDTASEVDDLEPDTVSAPLEGRD----------
-AEA-PTSPKPKIFLARYSYNPFEGPNEHP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EKELPLAAGDYVYVFGDMDEDGFYEGKLVD
GRQG--LVPSNLV---EPISGSPVLSCPLPQCT----DFG-------------PM--TLP
TGQS--------------KAL-------------KKDSLL--L-----------------
----------------------------------EEVEGSVE---RSPF-QMGKADSKTN
TMAVKILENKA-EACWPCSPPSMEKQGF------------SRSLPE---AKGALSVAPRQ
LQLQSVSATSAEITWVCSSHRYPHVVYLEDQEHARTPSGVSCYTFHGLHPGTCYRVRVG-
---VQLPRDLWQVPWKTMSYTITFDTPLAGPPFPPLDVLVEHH-TSPGFLVVSWLPVTID
SAGSSNGVQVTGYAVYADGHKVAEVAD---ATAGNTLLEFSQLQVPLVCQKVSVRTMSLY
GESLDSVPAQIPEDCFPC-HPFLETPPFSFI--------------------DVT------
-------FPVCH-------QK---LLQASLSTKAD----------LHIPGNCGE------
----PQANF--------LEAF--------------PEECPRKLTPE-SNPGSER------
A------G-------------------------NQAQGSTEAWK----------------
------------------------------------------------------------
-------------------LCGKDLLLWKSPQKHSLPL-SSGQSGTKEG---HYQ-H---
-------MCI---IRSPTPGFV-H-PS---------------------------------
---PECGPKKEPCPE---------------------------------------------
--------KVAV------------EKALGQSQ------------------------DAQM
FA-----------------------PHQQGA-SQY---YATDIN------HVL-------
--EEEEALSLDY--------------WHARKTKQRKMFRTQHG------------Q-GQ-
APRD-----KKMHLT---------------------------------------------
-------------------VLCPAPTSKVIKL----SSDDPEQLKIEANTPARVF

PF07653 // ENSGT00390000017228_1_Domain_3 (2336, 2395)

VALFD
YSPLAMSTNPKAAEEELTFQKGQLLRVWGSQDHHGFYYGECNGQVGKIPGHLVIEVEVGT
EQTD--GRWHLPAQGQLPSGTHLEDFEGLTD----P-----QGSFLMPQ-----------
-----------------GNSRTP--TLWTPKTMVAALDYDPRDGRAGVHAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGSHRGLVPAHLLDDLSVHGM------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLRELRAE------ESSE----PKGAGSSGPIRGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GHLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSNSGGQSSGGRSQPRPEEE---DAGDQLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPEPGDPSSP--
---LQHPAPLGT-------EEPPGAPPASPSREMP---KGSHE-DP--PVPCSGR---G-
---------------EQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEVCQGGDLGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEE--------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--A
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRPGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GNI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPH--LPAWEKGEPERRGRSATGKA------KEPLSRTT-ETREARG-
QDNFGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAR----RQQLLQRGYLSPDILFEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSAELKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPAPQTSQGG------LSQSRA-GGWA
RNSQE-VW----RNGTGQLPGQWFWPQ---------------------------------
--------------------------------LFSRGIRV------------EG------
---------QS------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPRPGDP---SV---
----------------------------------------------MEPWALSAWQSWTL
---GQGGEPRDIAPSIADTP-AALQVREVS----------------------SQPQAGTD
PEGAEAGLPSLRQQVGNSG-----------RGCP--RLEDE---------EVQ--A---L
PKATLNTSFGDQHNLELLRALGELQQRCAILKEENQMLRNSSFPET-EEKVRRLKRKNAE
LAVIAQRLEERARKL-QETNLRVVSAPVPRS-------GASLEMCRKALARQRARDLSET
ASALLAKDKQIAALQQECRELQARLTL-------V--GKE----GPQWFCV-RDFDRLLR
ESQREVLRLQRQIALRNQQELS---PPPR---------LPGPALPSR------------A
GAPK--PVAPGE----V----TSQEDVDSLPLVVGDP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKEAQNENARLVEENFQLSGRA--AEREQVEWENAELRDQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSVLGCSALGDHPPPPC-CST---PQPCRG---S-GPKDLDLL
PGSP-GHGTPKSSEPAP---------AALTGAPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSISLLPA-A-----------
-TESNPGASRIQVFLTRYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPLELA--DLSHS-------------SGPELSF
LSRGGGGSSSGGQSSGGHSQPRPEEK-EEDARDELSLSPP---------PEGLGAL-AVP
YPRHLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GKLH-QALGPGVPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPPQGAWEPGWERLEQRSATLQFTTLPAGPPDAPLDVQIELG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVSHEVTVRTMSPH
GESADSIPAPIAPALA-STCSAARVTCPS-----PRPSPEVRTPLASASPGPGDPSSP--
---FWRTATHGT-------PEPPGSPPASPIKQMP---KGAQE-EP--AAPCAQ------
-----------------EEAGAAMLQASEERRASEPPVGEGSSGPVAPCQMMQEAESTAG
E-ARPTVCP---IQGALTQR---APSTEACRGADPG--LRARAEREDPA--ELGVRLVNP
LVDHGRNSDLSDIQEEEEEEE-----EEKEEEELGSRTCSFQKQVA---GNSIRESGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEENEED-------
-NEEQ-KPGMG-FSQDPSPLEPVLLG-LGCDSGQPP----GLGLCSLS------------
-PEPSRAR---DHLEDMAGL---VSGS-SRRRGCGS-----------PEKLPNRRRP--P
DPREHCSRLLSNG-GPQASSR----PAPSWDRSSLPVIEGTRGGMEASGKGRPGTS----
-------------R-RCPRGRA----LESGL-ASCLSPKGSEIS------IEYDSED-EE
EVGS-GGI-----GITSSCYPADGEPWGMAPIGRPRGP----------------------
---LKVNSGP----S--LPAWEKGEPERRGRSATSRA------KEPPSRAA-EIGEARG-
QNGSGRKGHQR----RG--ARMPRLSTTEL----APPRSHS-ETLAHQNIPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVSS
PTG----RQQLFQWGYLSPEVVTEGT--GNSPFVYSTAH-TTAPPPKPRRSKKAELED--
-P----AQPCPGPPEP----I-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPRPEVGS------SDREPT-MPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPRPGDP---SV---
----------------------------------------------MEPWALSAWQSWTL
---GQGGEPRDIAPSIADTP-AALQVREVS----------------------SQPQAGTD
PEGAEAGLPSLRQQVGNSG-----------CGCP--RLEDE---------EVQ--A----
-------FFGDQHNLELLRALGELQQRCAILKEENQMLRNSSFPET-EEKVRRLKRKNAE
LAVIAQRLEERARKL-QETNLRVVSAPVPRS-------GASLEMCRKALARQRARDLSET
ASALLAKDKQIAALQQECRELQARLTL-------V--GKE----GPQWFCV-RDFDRLLP
GRVRRGWTGL---G---MQP-------------------MGPVLRCQ------------L
LA-----PVHFQ----V----TSQEDVDSLPLVVGDP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKEAQNENARLVEENSQLSGRA--AEREQVEWENAELRDQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE----VESLEARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSVLGCSALGDHPPPPC-CST---PQPCRG---S-GPKDLDLL
PGSP-GCGTPKSSEPAP---------AALTGAPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVSA------------------------------
----GRGASRIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPLELA--DLSHS-------------SGPELSF
LSRGGGGSSSGGQSSGGHSQPRPEEK-EEDARDELSLSPP---------PEGLGAL-AVP
YPRHLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GKLH-QALGPGVPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWTTFCNLRPGTLYQARVEA
QLPPQGAWEPGWERLEQRSATLQFTTLPAGPPDAPLDVQIELG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVSHEVTVRTMSPH
GESADSIPAPIAPALA-STCSAARVTCPS-----PRPSPEVRTPLASASPGPGDSSSP--
---FWHTATHGT-------PEPPGGPPASPIKQMP---KGAQE-EP--AAPCAQ------
-----------------EEAGAAMLQASEERRASEPPVGEGSSGPVAPCQMMQEAESTAG
E-ARPTVCP---IQGALTQR---APSTEPCRGADPG--LRARAEVGIGD--TLS------
--------------------------------QNRGRCCAW------------AISPARP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEENEED-------
-NEEQ-KPGMG-SSQDPSPLEPVLLG-LGCDSGQPP----GLGLCSLS------------
-PEPSRAR---DHLEDMAGL---VSGS-SRRKGCGS-----------PEKLPNRRRP--P
DPREHCSRLLSNG-GPQASSR----PAPSWDRSSLPVIEGTRGGMEASGKGRPGTS----
-------------R-RCPRGQA----LESGL-ASCLSPKGSEIS------IEYDSED-EE
EVGS-GGI-----SITSSCYPADGEPWGMAPIGRPRGP----------------------
---LKVNSGP----S--LPAWEKGEPERRGRSATSRA------KEPPSRAA-DIGEVRR-
QNGSGRKGHQR----RG--ARMPRLSTTEL----APPRSHS-ETLAHQNIPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVSS
PTG----RQQLFQRGYLSPEVVTEGT--GNSPFVYSTAH-TTGPPPKPRRSKKGEQT---
-P----SPEGDCPPEP----I-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPRPEVGS------SDREPT-MPQA
ESQVSEEL----SSQLGVCLSR-----ASEVGPGLW------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------DLVKQNSELAEAPETLAKHCSGLREENSQLRR-GFPDS-SEKARRLKVKNAE
LAVIARRLEERARKL-QETNLRAGGPGPGPGEN-----GASLELCRQAFARQRAKDLTEQ
TSALLAKDRQIEDLRQECRDLQARVASCQ----------------GQWLNV-TDFDQLLR
ESQKEVLRLQRQVTLQTF-RGPAA---QRAASPPP-------------------------
--------------------GAPL---QEPGPDEAAEAQELKLQLQALEQSLSERQKCCE
SLELDVDKAQQRVQEAEGRLHQVLSENSWLAQENSRLQERA--QWLEKVGSENSEMRGKL
E--LLTEERDSAALLSS--QLQQQAS----------QSEAGRQQLQKELREALGALA--A
QRGEVQRLQQEREQMQ-REHQEAVQTLEA---------HIRELELPRSHHAHD-------
SKPAQLFRGKWAKK---ATC-----------------------------LPEGPGLPDAR
TP-----------------------------------AKKASPQA--GAS-E--------
-----------AASPQLGL-QAPEAED----SEADG---L-------PRPPEPAAPRGPH
GQDA-QGPAKLKIFLARYNYDPFAGPND

PF07653 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

QPEAELPLTAGDYIYIFGDMDEDGFYAGELMD
GQRG--LVPSNLV---EQISDGEILSFQPPE--GSDSCPD-------------SSQEGKS
PSES--------------------------------------------------------
------------------------------SSPEGKYNVYVD---NELR-QNIRAGAQTR
A-TIDNLDLKT-RAY-RISVQSVLERGC------------SNRLQCSFLVGRGFCSAPTQ
LRLRSLTATSAEISWLYSNSSYPHMVYLNEQEHNLTKAGVCRYTFQNLQPSTSYCAHVEA
R-PLGDAA---KKPWEETSSSIAFTTPWAGPPDPPLDVLVEGH-TSPGALLVSWIPVTID
SAGTSNGVPVAGYAVYAGGQKVAEVPS---PTAGNVVVELAQLPHQKLSQEISVRTMSHY
GESLDSVPAHIPGDWLKQCGLARSAQSFPVI----------AAT----------------
----------------------------------------------------------WW
TWPGWR------------------------------KRSS--------------------
------------------------------TGTCGGPGDPAKR-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------RSSGSRRAR
AGPWGC------------------------------------------------------
-----------------------------RKRPPA-------------------------
-----------ESPA---PCYIR--PPRGGNKILKASP----------------------
-----------MVPAAGPWFR---------A------PGGSPLKGKAASDPLRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALWD
YDPQLMSPNPEAAEEELAFHRGQLLKVWGDLDPDGFYHGECCGRMGYIPGDMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VQVEG
SDV----LKQLLRQGLLPHEVSLDNLLELSTQPHSP-----KKSFSVAR-----------
-----------------GAPQRA--QFWHPQT

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYRPRKGSS-LSLTEELTLSAGD
VVTVLGSVDDNGFFY---------------------------------------------
-------------------GELNGQRGLVPSNLLKTPALNAE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GHGGEPGGAAPSIGDTP-AVLQVGELDTL------ESSE----PQGTQSPGPVGGAD
PEGTEPGLPSLGQQASSSG-----------PSCL--RLDDE---------EVE--A---F
RKGKLNMGFGDRPNPKLLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPMPCP-------GASLELCRKALARQRAQDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLYV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPPL-P-SR---------APGPTAGVR------------A
GAPA--PGAPGE----A----ATQEDVENPPVILGEP--EKQQRVQQLESELSRKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAR-REHEGAVQLLEXX--XXXXXVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---SSALGCGVLGDRPPPPCCCST---PQPCRG---S-GPKDPDLP
PGSP-GRCTPKSSEP-----------ATLAGAPRRA-TKKAESLS--NSSR---------
-----------SESIHNSP-KSCPT-EVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPSELA--DLSHS-------------SGPELSF
LSGGGGGSSIGGQSSGGRSQPKSEEE---AAGDELSLSPQ---------PEGLGTPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRHLVILKQLAHSVVLA---WEPPP---ERVELRGYHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-APL-HVSVQALTSRGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2334)

SDPLRCCLAVGAQARVVPRQ
LRVHRLTATSAEITWVPSNTNLAHAIYLNGEECPPARPSTYWATFCHLRPGTHYQARVEA
QLPPGGSWEPGWERPEHRAATLKFTTLPAGPPDAPLDVQIEPG-PSPGILVISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVDLSQLQLLQVCSEVAVRTMSPH
GESADSIPAPVAPALA-AACLPATVSCPS-----PRPGSEARPSLAPACPGPGDPSSP--
---LRRPEPHET-------REPPGPPPASPLREKP---NGSQE-EP--LVPCSQ------
-----------------EEAGAVVQGTSEDRRASEPAVGER-TGPAPSSLAQEEAKWTTG
E-AHPAPCS---TQGPLSQK---APCAEACLRGDTGPGLRPRAEKEDTA--ELGVRPVNS
LVDHGRNSDLSDIQEEEEEEEE---EEEEEEEELGSRTCSFQKQVA--AGISIRENGVEP
---Q----PEPSCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEE-----------
--DEE-RPGAG-SSQDPSPPEPASLG-LGCDGRQPQ----GPGPCPLS------------
-PEPSSAG---DHLEDMPGL---AGGS-SWRRGSGS-----------TEKPPNRKRS--P
DPREHCSRLLSNG-GPQASGR----PGPTRERGGAPVGEGSRGGPEAGGRGRPAPS----
-------------R-RCPRGQI----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGG-GSI-----SITSSCYLGDGEAWGTAPIGRPRGA----------------------
---LKANSGPSPYSH--LLAWEKGEPERRGCSATGRA------KEPASRAI-EIGEPRG-
QDSSGRRDPLR----RG--SRPHRLGATEL----APSRSPP-EVLAYQDLPVR

PF07653 // ENSGT00390000017228_1_Domain_3 (2334, 2396)

VFVALFD
YDPVSMSPNPDAGEEELPFREGQFLKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVDS
PTE----RQQLLQRSYLSPDVLIDSAXXXXXXXXXXXXX-X--XXXXXXXXXXXESE--G
-P----AQRCAGPPQL----V-SSASLRAP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RAMVAAFDYNPRESSPNMDVEAELPFLAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGRRGLVPSNFLEGPGPEVGG------SDREPG-TLQA
ETQDWASS----TQG--------------PTVPLGWPCAPGPGSFPRFE-----------
-------------------LGVPQGTGEKMRGLLSKGKQLLRKLGSGKKE----------
-----------------------------------------------

------------------------------------------------------------
--------------------------------------------------------LRQL
QQQLHRERDCAVRQARDLQRQLADELLNRGYGGRQGGGGSGGAFNSSMAGGAAQCRCRLQ
DVLAKLRWETDGEQAARIRHLQAALDVERSLFLKYILENFHWDPAAVLSGPAVRSQNRTP
NTEPAIAMAIIS------------GAAT--PALEGAGE----LPPGLSSRAAV-------
--TGPAAAPAPTLA---ERV-RSSTLP-----SRPRSLDSLC-PPRPRA-PGLCLDNTSR
SLDGSPGRAQSPPGS------------GE--PED-RSRLQLGGG--EKGPEAEGAPPTMP
SPRPTAYSELVKQNSELAEALDTLARHCSGLRHENSQLRR-GLPEA-DEKVQRLKLKNVE
LAGIAKRLEERARKL-HETNLRTPAAGPPPGPAAGNPSRSAVELCRQAFARQRAKDLTEQ
TSALQAKDKQIEDLRQECRDLQARMAACQATA-----GQG----SAQWLNV-NDFDHLLR
ESQKEVLRLQRQVTLQKCFKGSHA---QQ-------------------------------
-------------------------------AQQAQEAQELKLQLQALEEKLSERQKCCE
SLQLDVGKVQQRLQEAEGLLQRLTTENNRLAQENSRFQEKM--QWAEKVDSENSDLRGRL
E--QVTKDRDAATLLTA--QLQQQVS----------QVESSRQKLEKELQEALATLA--A
QQEEVQRQQRDQEQLQ-REHEEALQALQA---------QIRELERPSIQKAKE-------
IRRSQLPRGKWAKK---VTR-----------------------------PLEGPGLPDSG
PA-----------------------------------VQKASTQA--SAT-N--------
-----------AGPGPLGL-LASPTPQALTASAAAA---VPSDPAPEPESPTTDSHSGHS
GHSG-HDPSKLKIFLARYNYDPYAGP

PF07653 // ENSGT00390000017228_1_Domain_1 (1107, 1157)

NEQPEAELALTAGEYIYIFGDMDEDGFYSGELMN
GQTG--LVPSNLV---EQISDSEILNFQLPE--GSDLCLD-------------PSQEVKP
LGGG--------------------------------------------------------
------------------------------G---ESTSPEVD---RELW-QNIRAGAQKQ
V-TVEELDLKT-RAY-RISVQSVMERGC------------SNPLACSFLVGQDFCLAPTR
LRLKSLSPTSAEISWLYSNSNYPHMVRLNEQEHSLAEAGVCRYVFPDLQPSSRYCVHVEV
R-PPGEAS---GKPWKEMASSIAFTTPLAGPPDPPLDVLVECH-SSPGSLLVSWIPVTID
SAGSSNGVPVTGYAVYADGQKVTEVAS---PTAGNVVLEFSQLQRPKLFQEVSVRTTSHY
GESLDSVPAQIPGEWCKQASAYPSPQAFPVN----------HNC--------GDPAHPHI
PAPSRLPVPTGQ-------EK---SVLASFN---------T-KASSPFPAGCGRPK-VAV
AWDGLL------------------------------EDACRRRSP----KPSEGELLSPR
D-----------------------------AGAPPGPGEARTPSP------------LSF
G-----------------------------RKDAYGP-----------------------
-------KAGKDCKLWG-------LRHI----------SDGPPAG-------EERSA---
-------DTP---KGSSS------------------------------------------
------------------------------------------------------------
---QLPEAYAVV---------------------------------------TSPEEEDQY
VTPWGA------------------------------------------------------
-----------------------------RTIGPKKEIRLGRG------------A-SR-
PAGRKKEA-PPPPPR--PLLYQS--SSEKMTKILKTGP----------------------
-----------VGPGAALWFR---------P------PENNALKGKTANHPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALWD
YDPQLMSANHATAQEELTFHRGQILKVWGDRDPDGFYHGECSGRMGYIPGNLVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VQVEG
SDV----LKQLLQQGHLPSEVSLDGLVGLPTQPPGP-----QKSFSVAR-----------
-----------------GGPRRA--QLWHPQT

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2614)

MVAAFDYQPRKSSS-LSVTEELTLSAGD
VVTVLGSVDDNGFLY---------------------------------------------
-------------------GELNGQRGLVPWNLLKTPALNGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------PWAL-VWESWTT
---GQGGQPGGTAPSIADTP-AAPQVGKLRPG------ESLE----LEGAKPPGPVEGTD
SARALVGLPIAGQQAESPG-----------PSCP--KVDDE---------AAA--S---F
PKVKVNIGLGDRPNLELLRALGEMQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRAQDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPPPLP---R---------PPASAIRAP------------A
GAPA--PGAPGE----X----XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXAQAEAK-REHEGAVQLLE-S-TLDSMQARVRDLEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSAPGDCLPPPCCCST---PQSCRG---S-SSKDLDLP
PGSP-GRCTPKSSELAS---------AALAGAPRRT-AKKAESLS--DSSR---------
-----------SETVHNSP-RSCPTPEVDTASEVEELETDSVSLLPA-A-----------
-PEGPRGGAKI

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGRGSSSEGQSSGRQSQPAPEEE---DAGDELSLSPP---------PDGLSETPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRHLVVLKQLVHSLVLA---WEPPA---GQVELHGYHICVN---GELR-QALAPGAPLK
A-VLENLDLQS-GLL-HVSVRALTSRGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDPLRCCLAVGARAGVGPSQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECLPAHPSTYWATFCNLQPGTPYQARVEA
QLPPGGSWEPGWERTEQRSATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
VAGSSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLRVCREVAVRTMSPH
GESADSIPAPIAPALA-LLCQPAEVSCPS-----PQPGSEARPPLAAASPRPGDPSSP--
---LQHPVPHGT-------REAPGAPPAGPPSEAS---RASQE-EP--PASCTQ------
-----------------GGAGLAVLGTLEESRASAPAMGDGGSGPVAPELAQE--EWSTR
E-ACLLSDS---TQGALAQG---VPCTKTSR-GDAGSGLQARAEREDPA--ELGVCSVNS
LVEHGHSPDLSDIQEEEEE---------EEEAAMGSRPCSFQKQVA---GNSIKENGAKP
---Q----PDSSCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEEEEE-------
--EAE-EPRVGRSSPGPGLPEPTLLR-PACDSAWLQ----GPGLCPLS------------
-PEVSRAG---DHLEDMPGL---VGGS-SRRRGCGT-----------LEKPPNRRRS--P
DPREHCSRLLGNG-GPQPSGR----PGPTRERGGTLVGEGTRAGPEAIGKGRPALS----
-------------R-RCSRGQA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGSGEGV-----SVTSSCYPGGGKPXXXXXXXXXXXX----------------------
---XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXX------XXXXXXXMTETEDPRG-
QDSFGRRGPMR----RG--TRAPRPGSSEL----APPRSPPEETRASQDLPI

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RLFVALFD
YDPLSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGVGRIGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVDS
PAG----RQQLLEQGYLSPDVLVEGSXXXXXXXXXXXXX------XXXXXXXXXXXESEG
-S----VQPCTGPPKL----V--SAGLKAP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RLMVAAFDYNPRENSPNLDVEAELPFQAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLESPGPEAGG------LDREPG-IAPA
ENQHWAST----TP--------------GSPAPPGWPCAPSPGNPSRTE-----------
-------------------LGEPQGTSEKMRGLLSKGKQLLRKLGSGKKE----------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRPGNP---GA---
----------------------------------------------MEPWALPAWQNWAP
---GQGGEAGGTAWSVVETP-AALQGTEQKPE------DSCE----PEGTWSSGPMGGMD
PEGTETELPSLGQQAPGSG-----------PDCL--RLEAK---------EVE--D---S
PKAKLNVGIRDRTNLELLRALAELQQRCAILKEENLMLXXXXXXXX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX-------X--XXE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPLR---PR---------PRGPAAPAR------------A
GKPA--PGAPIE----X----XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXAQAEAK-REHEGAVQLLE-S-TLDSMQARVQELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDRPPPPCCCST---PQPCRG---S-GPKDLDLL
PGSP-GRCTPKSSEPTL---------ATLAGISRRA-SKKAESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEADSISLLPA-V-----------
-PEGRQGGARIQ

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

VFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLLTSLPPELA--DLSHS-------------SGHELSF
LSGGGGGSSSGGQSIGGRSQPRPKDE---AAGDELSLSPT---------PEGLGEPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRHLTVLKQLAHSVVLA---WEPPP---ERVELLGYHICIN---GELH-QALGPGTPSK
A-VLENLDLRA-GPL-HVSVQALTIQGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDPLRCCLVVGAHARVLPSQ
LQVRRLTATSAEITWVPSNSNLTHAIYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QPPASGSWEPDQERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSLLVEVSQLQLLQVCREVAVRTMSPH
GESADSIPAPVAPALS-AACLPVKVSCPS-----PRPGPEARPA---PGPGPGNPSSL--
---IQHTEPPGV-------GMLPEGPPENLPRDIP---EGSQE-DP--SAPCSQ------
-----------------GEARTAVLGAPEDRRASEPVLGERMPGSSAFALVKEEAERTEG
E-DHQAPCS---TLGALTQR---VACTDSCHGGDTASELKPRVEREDMA--ELGVHLANS
FVDHGRNSDLSDIQEEDEE-----------AEELGSRTCSFQKQVA---GNSIREDEAQP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEEEE--------
-EKEK-KLGAGYSSQDPDLPESALLG-LGCDRGLPR----GPGPCPLS------------
-PKSLGAR---DHLENMSGL---AGGN-SQRRGSGS-----------PEKPPNCRRS--L
DPREQCSRLLSNG-GPQSSGR----PGPPRERGGPPVGEGNRGGPEAGGRERLAPS----
-------------R-RCPRGWT----PETGL-ASCLSPKCLEIS------IEYDSED-EQ
EADSGGGI-----SVTSSCYLGDGETWGTVPTGRPRGP----------------------
---VKANLGLSSYTR--LPAWEKREPERRGRGATGRA------KEPPSRGT-ETGEPQG-
QDSCGRKGTPR----RG--GQVPRPSASELPL----PRITP-EVLPRRDLPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2395)

RLFVALFD
YDPLSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRAGYIPPNVAE

ENSGT00390000017228_1_Linker_3_5 (2395, 2491)

VAXXXX
XXX----XX-XXX--XXXXXXXXXXXXXXNSSFVHSTVR-TARPPPKPRRSKKAELDS--
-P----TQPCAGPPQL----V-SSAILKAP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

HSMVAAFDYNPQESSPNMDVEAELPFRAGD
IITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------SDREPP-SPQT
ESQNWAST----TQG--------------YPAPPGWPCGPGSSPR--IE-----------
-------------------LGGPQGTREKVRGLLSKGKQLLRKLSSGKNE----------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRLGDP---RA---
----------------------------------------------MEPWALPAWQSWTP
---GQGRGPGGATPSFADTQ-AALQVGEPRPE------ESSE----PEGAQSLATMGGVE
PEGAKTGLPNLRHQAAS-S-----------DSCP--RLEDE---------EME--G---F
GQGQLNMGFGDRPNLELLRALGELQQRCDILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPVPRP-------GASLELCRKALAHQRARDLSET
ASALLAKDKEIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPP---PPPR---------PPGP-AAPA---RA--GA----
--PA--PGAPGE----A----TPQEDVENPPAGLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKQQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGYSTLGDHPPPPCCCST---PQPCRG---S-GPKDLDVP
PGSP-GRCTPKSSEPTH---------ATVTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGARGGARIQVFLARYSYN

PF14604 // ENSGT00390000017228_1_Domain_1 (1102, 1157)

PFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSL
LSGGGGGSSSGGQSSGGRSQPRPEDE---AEGAELSLSPQ---------PEGLGGPPAVP
HPRGLVVLRQLAHSVVLA---WEPPP---ERVELCGYHICVN---GELR-QALGPGVPPK
A-VLENLDLRA-GPL-RVSVQALTSQGS------------SDPLRCCLVLGTRAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QLPPRESWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQQLQACSEVAVRTMSPH
GESADSIPAPVPPALV-AASLPATVPCAS-----PRPGSEARPPLAPASPGPGDPTSP--
---LQRPDPRGA-------REPLGGPPPGEM---S---RGSHE-EP--LAPCSQ------
-----------------KEAGAAMLGASEDGKASEPAMGERAPDPAVSPLAKEE------
--TLPAPSS---AQGALAQR---VPCAEACRGGDPGSGLRPRAEREDTS--ELGGRLMNS
LVDHGRNSDLSDIQEEEEE---------EEEEELGSRTCSFQKQVV---GHSTRENGAKP
QP-Q----PDPFCETDSDEEILEQILELPLQQFCGKKLF-SIPEEEEEEDEEDEEE---D
EEDEE-RPGAGCSSQDPGPPAPAVPG-LGCDSGQPR----GPGPCPLS------------
-PEPCRAG---DRLEDVPGL---AGGS-GRRRGSGS-----------PEKPPNRRRS--P
DPREHCSRLLSNG-GPQASGR----PGPTRERGSPPMGEGTKGLPEAGGRGRPPPS----
-------------R-KCSRGRA----PESNL-ASCLSPKCLEIS------IEYDSED-EP
EAGS-GGI-----GITSSCYLGDGEAWGTAPIGRSRGP----------------------
---LKAHSGPNPSPR--LSAWEKGEPERRGRSATGRA------KEPPSRAT-ETGEPRG-
QDGSGRRGPPR----RG--AQASRASTTDL----APLRSPPEEALLYQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGEGRMGYIPCNMVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2493)

EVAVDS
PKE----RQQLLQRGYLPPDVLIEGSGSGNGPFVYSTAR-TAGPPPKPRRSKKAEVES--
-P----AQPCSGHTQH----T-SSASLKSPRT

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGRRGLVPSNFLEGPGPEAGG------QDREPG-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------MEG--LG--HC---QAAGS
SQGCAGDQALAKHNALLLRALQELQRCCASLKEENGLLRKSCFPAT-EEKVKHLKRKNAE
LALIAKRLEERARKL-QEANLKVSGQ----------------------------------
----------------------------------------------EGLRL-LDFHRLLR
ESQQEVLRLQRQIALKNFKETLPTPGTSPQAP----------S---------LSK-GLQL
GAPTLAMGAPGKKGCGPLRSAGG--------LECLLAGPESNQQVQQLEFELRKKRKKCE
NLEHEVRKKHKRCKELETQLQAAQGENVRLAQENTQLKGKA--EWAQQVDSENAALKLQV
L--LVTKERDSALQESQ--GLQAQLEDLEQVLKHLNHAAERRQQLEAAHEEALLALQ--Q
KQEEVGWLQQAQAAAE-REHAGAVQLLEE--RFPTPGARVQALEDQCRSHVEQLSHLSQE
LRRVRPPAGKSDPP---TSAGVTPEL----PLLPCCCVPQPQCCQWE-KDQPGI-FGAPS
GS--TVHCSDKTS--------D-------AAAPSWSQVERRASQP--SPS----------
---------E-SDSVPESP-TSCPTPEVDTASEMEDLDADSVALI--------------P
APES-HGPAKLQVFLARYSYNPLDG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGHMDEDGFFEGELMD
GRRG--LVPSNFV---ERVPDDDLASDLTQSS---------------------------S
HGRSTS--------SGEKSDDSCA---------ETSASSS---LSGPGDREESVRHTAVP
YPRKLTLLKQLPRSIVVG---WEPPLLPAGCPAVWRYDVSVD---AELC-QSVESGAQTQ
A-EIENVDLER-KAY-RVSVQSVAEHGR------------SDALRCTLCVGPGVCPAPGL
LEVRSVTATSAELTWVPCDSNFVHAVYLGEEECHSAKPGVYWYTFRSLRPSTQYVAKVEA
R-PPGVLWELPQERREQDSAVIHFTTPVAGSPDAPLDVQAEPG-PSAGILGISWLPVTID
AEGSSNGVRVTGYAVYADGQKVMEVAS---PTAGSVLVELSQLQMFQMCREVSVRTMSLY
GESADSVPAQIPPALLKASRHPSLPQA--VG----------SPSLRSSLL-HGEPRGSPP
Q---RTPVARSP-------AR---LLPPCTHCSAAR-----------STAGCLPGPAGGA
EPRGPDEGF--------QLQGS--VSGRE---DPGPGAASDRDSERNGSSAQEFARGSPG
K------KP-------R---------KEISRGDSSGPGPKVKREEE--KRADAGKWQLNL
LAEHGRSSDLCDILEEEEEENERD--TQEGARWLGGKVQWSGSSMQE--------NLSRG
-------QTGPQSPSGFEKLCLTFPLNLPLPQNCSKTLF-SIPEVTEEEEEEEERVH---
-------SAP---ASSPR-GPG-PAEEQKCPSGIAR-CRWPPRLP----------KSAPL
SWTQTRGGCDWGCWEGRATPAGDTSPQWGRKEGGSS---------------PDRARELAE
EGRKKCSDVTKGWSHPAG-GSLYRAQSLAGQ-------------LNAVG-------RASS
VEGAEICGPVSQA--HSSALPA--TPASPG--SNS---SSMEISI------EYDSEE-DQ
DLSSPSSPGRRD--------------WPAGHMEESQASRSTRE------------R-NT-
AFGRLAWCGALRMAG--WGSWVP--AAPQGRASGNSPGF---------------------
LLQASGNGDLRSHGS----LGSPAQRGNESQ------ISNSSTSCSGTDGPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAAEEELPFREGQVLKVCGEKDADGFYRGECAGRAGYIPCNMVSEVELES
EEA----KEELLTRGYVPAGPSAAVARGTGN-GTFA-----P--PPRS------------
--------------------LTA--PPPKPRRAKK-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------IPREREPVIRQLLRWKEAEMRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCGRARAP---------EVA-AAQCRCRLQ
EVLAQLRWETDGEQASRIRHLQAALDVERQLFLKYILEHFRWHPALSGVPDP---QTVES
SEERSPETAVKS---------ARRLESL--GSLNAGTR--------ARSRSLERVPS---
---ASSGSPDSLLP----V--RVSSLDSLAPV-SSRSLDS-T-LSRPKA-PE-----SSS
PDSSILGSLCPPLPP----------------PLEHRRPDDPPGREESRSQTCE-ALT--P
LSPGQDYGELVKQNSELTEALQVLALRCSSLREENLKLRRAGFPDEADEKVKRLKVKHAE
LTGLARRLQDRARKL-QETNLRAMSAPVPG------ESLASLELC-QALTRQRARDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGLSSAQLPGGGAP----CAXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX--XXX-------------------------------
------------------------------XXXXXXXXXX-XXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXX--XXXX-XX----------XXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXXX-XXXXXXXXXXXX---------XXXXXXXX------XXXXXXXX
XXXXXPSRDKQEK--------------------KGDSL------------QENPFALREP
ASAPQV--------------PDRVP--TSQPLDSSPHTKKTSSQS--NSSS---------
---------E-VESMWATVP-SCPTLDVDTASEVEDLEPDSVPLTLEVGG----------
-SEA-PATPKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KVFLARYSYNPFEGPNEYPESELPLTAGDYVFIFGDMDEDGFYEGELED
GRQG--LVPSNLV---EQIPDSDILGCLPPESP----DHG-------------PT--RLP
AGQG--------------KAS-KD---------GSGHSLL--P-----------------
----------------------------------GKAQGTVD---RGPC-QIVWVGSETE
V-AREISDAKM-EDCWLGSWQSVDEQGF------------SKPLLG---ANQILCVAPTQ
LRLRSIAATSAEITWGGS--SYPHMVYLGDVECTQTPAGENSTTXXXXXXXXXXXXXXXX
X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------XXXXXXX--
----XXXXXXXX-------XX---XXXXXXXXXXX------X---XXXXXXXXX------
----XXXXX--------XXXX--------------XXXXXXXXXXX-XXXXXXX-XX--X
X------X-------------------------XXXXXXXXXXX----------------
------------------------------------------------------------
-------------------XXXXXXXXXXXXXXXXXXX-XXXXXXXXXX---XXX-X---
-------XXX---XXXXXXXXX-X-XX---------------------------------
---XXXXXXXXXXXX---------------------------------------------
--------XXXX------------XXXXXXXX------------------------XXXX
XX-----------------------XXXXXX-XXX---XXXXXX------XXX-------
---X-XXXXXXX--------------XXXXXXXXXXXXXXXXX------------X-XXX
XXXXXXXXXXXXXXX---------------------------------------------
-------------------XXXXXPSAKAIRM----SRAGPPQLGTRVDSPAR

PF07653 // ENSGT00390000017228_1_Domain_3 (2334, 2396)

VLVALSN
YDPL-MSASPEAAEEELAFQKGQLLKVWGE----------HDGQVGNSPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

AEAGT
EWTG--GRWHLPGQGPLPSGACIDDFEGLTS----P-----LSSFPMAP-----------
-----------------GSSRRP--SLWTP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

TTMMAALDYDSRNRQAGGSVKGKLSLRVGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHVFLH--------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLLRLGDP---GA---
----------------------------------------------MEPWAQPAWQSWIP
---GQEGEPGGAAPSTADTP-AALQVGELRPL------ESSE----PEGAWSPGPVGDID
PEGTETGLPSLGQQAASSG-----------PSCP--RLEDE---------EVE--A---F
HEGKLSVGFGDRPSLELLRALRELRQHCALLKEENQRLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLKVVSAPVPRP-------GPSLELCRKALARQRTRDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLHL-RDFDRLLR
ESQREVLRLQRQIALRNQQEP--S-PPLR---------PPGPTVRVK-AGAP--------
---T--PRAPGE----A----TPQEDVENPPVVLGEP--EKQQRVQQLESELSKKRKKCQ
SLEQEARKKQRRCEELELQLREAQNENARLVDENSRLSGRA--TEKDQVEWENAELRDQL
L--GVTQERDLALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQAQLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSTLGDRPPPPCCCSN---PQPCRG---S-GPKDSDLL
PGSP-GRCTPKSSEPAP---------ATLPGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPERVLGHHSQLFQSPPTSQTPA-A-----------
-PEGSRGGARIQ

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

VFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPSELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSVGGRSQPRSEEE---TAGDELSLSPS---------PEGLGEPHAVP
YPRHLAVLKQLAHSVVLA---WEPPP---ERVELHGYQICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-RVSVQALTSRGS------------SDPLRCCLAMGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QLLPGGSWEPGWERPEQRTATLQFTTLPAGPPDAPLDVQIEPG-PSSGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVTS---PTAGSVLVELSQLQLLQVCSEVAVRTMSPH
GESADSLPAPVGPALA-AACLPARVSCPS-----PRPGSEARPPLAPASPAPGDPSSP--
---LRYPEPHGT-------REPHGVPAASPPGET----RGSQE-EP--TAPCSQ------
-----------------EEAGAAVLGTSDDRRAREPAVGERAPGPAASSLARDEAEGTAG
E-ACLAPCS---TEGAPVPK---VPCAEASLGGDTGAGLRPRAEKEDMA--ELGVRLVNS
LGDHGRNSDLSDIQEEEEE---------EEEEALGSRACSFQKQVA---GISVRENGPKP
---Q----PEPFSETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEEEEEE-E---E
EEQQQ-QPGAGSSSRDRSPQEPALLE-LGGDS-RPQ----RPGPCPLS------------
-PEPCSAG---DHLEDMAGL---AGGS-SWGRGSGS-----------TEKPPNRKRS--P
DPREHCSRLLSNG-GTQAAGR----PGPTRERGGPPVGEGARGGPEAGGRGRPAPS----
-------------Q-RYPHGRT----PESIL-TSCLSPKCLEIS------IEYDSED-EQ
EAGG-GGV-----SITSSCHFRDGEAWGTAPIGRSRGA----------------------
---LKANSGPSPYPR--LPAWERGEPERRGCSATGRA------KEPASRAT-EIGEPRG-
QDGSGQRGPLR----RG--ARVPRPDATEL----APPRSRPEEVLAHQDLPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RVFVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRRGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VAVDT
PAG----RQQLFQQGYLSPRVLVEGS--DSLAFLSSTAR-TTGPPPKPRRSKKAESEG--
-P----AQHGAGPPEP----V-SSASLRAPR

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2616)

CMVAAFDYNPRESSPNMDVEAELPFRAGD
IITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------SHREPG-TPPA
ESQRTRKR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
---------------------------------------REREAEIRQLLRWKEAELRQA
QELLQRERDAAMRQARDLQRQLAEELVGRCKGQGQGLSGE--------------GRAKLQ
EVLGKLRWEVDGEQAARIRHLKAELELERSLFLKYILQRFEGEQPTLGFSP------RGP
KSGPHSLSSLMAA---------CRASRS--HSLEGGLNHSCESPKK-QGRSCCAWSKSHS
SREQQQQAPENALE---KET----SME-----TNNRS----S-QEQQKT-PHITLGEEMS
MENGV------NKGE------------GEDVPLEEKEASEETGG--QEQPQD---QQAQE
VLSGSGYDQLVKQNAEFLKALVVLEQRCTHLKNENTLLRKSSFPEM-QDKVKRLKKKNVE
LASIAKRLEEGAKRL-QESSLKFGSSSIPVA-----MSRSDMELYKTSFARQRAKDLSEQ
TSVILAKDQQLEALRRECWELHSKR-----SA-----GKE----SQYMLSI-CDFERLLR
ESQKEVLRLQRQIMQSES---LPA------------------------------------
--------------------GNGIENK---GNSLLKTDPDTEYRLQVLTEELSSKSKECE
ILGREMEEKQKRCDDLETQLKEVLDENARITEENSHLEKKS--EMAQKMENENTEINAKL
M--QATDARNSAVQLTK--GLESKVENLEQIIRNLKEIVERRQQLVSEHEQTLLVLQ--T
KDEEIQQLQQIQAKTK-KENEETVEQLKA---------RVKELENQRHSQTECFHRLSRA
HGQLQKKKSEILEL---ESSRASYT-------------------------SESIT-YPPK
GN---------------------------------------EDNF--HIS----------
---------G-KNSIQNSS-RSRSNPKEDTTDEIQEPETDKISMN--------------L
ELEN-RDPTKLRVFLARYSYDPF

PF07653 // ENSGT00390000017228_1_Domain_1 (1104, 1159)

DGPNKNPETELPLTAGEYVYICGEMDEDGFYEGELMD
GRRG--MIPSNLV---EEVSGNDLISFHPLEAS-----YH-------------CYHEIGC
PYRNAS--------SEEGNDNTEE---------DLCINLL--------------------
----------------------------SNEFRGEIYNIYVN---ADLC-CNVKHRRQMK
A-MIENLALKF-HSY-RISVQSVTDKGL------------SDKLQCTFLVGHGFRIAPTL
LELRSVTATSAEITWLPSSSNYTHTVYLNEKEYDVTETGVYWYTFRNLKPNSQYHVKVEA
R-AH-------FEELEQKSREMTFTTLLVGLPNPPLDVQVHPG-SSAEFLNINWLPVTID
AAGSSNGVKVTGYAVYINGWKVTEVMS---PTAGSVSLETTQLPMFHGPCMVFVKTLSPY
GESVGSVPALIP------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQLGDR---GA---
----------------------------------------------MEPWALPAWQCWTQ
---GRGCEPEDASPSIADTP-TALQVRGLRSE------ESSK----PEGAHRP--AGNTD
PEGTDTGLPKLGQQAESHG-----------YSCL--QPEDE---------DAQ--A---C
-KAKSNVGFGVRSNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------PPGPTALSR------------V
GAPA--PGAPGE----A----ILQDDVDSPQVALGEP--EKQQRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVKQERDSALRRSQ--GLQSKLESLEQVLKRMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-V-GP-LEHARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSVLGDHPPPHCCCST---PQPCKV---SPNDIDLDLP
PGSP-GRCTPKSSEPAL---------ATLAGVPRRT-AKKVESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGNSGGARIQVFLARYSYNPLEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DLSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRRLVVLKQLAHSVVLA---WELPP---EKVDVRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRIHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQVEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESTDSIPAPVAPALD-PACQSARMSCLS-----PRPSPEVRAPLASVSPGLGDPSFP--
---LRHPAPDGT-------QDSP----ASLPMEMS---KGSQE-EP--PVPCSQE-----
------------------ESGAAVLGTSEEKRAIEPALGWEGPSPVAPSLAKQEVEWTSG
E-VGPTPSS---TQGEPAQK---APSTEACHGGDLGSGLKLRAEKEDVS--ELGVRLVNS
LVDHGRNSDLSDIQEEEEEEE-----EEDEEEDLGSRPCSPQKQVA---SNSIRENGAKE
---E----EEEEEEEEEEEEEEEEEE---------EEEE-EEEEEEEEEEEEEEEEEEEE
EEGQE-QSEPASSCQDPSQSELALQG-LDCDSSQSQ----GPGLCPLS------------
-PEPSRAR---EHLEDVLGI---AGGN-SRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQTTARPG----PLRERGSLPVIEGIRVGQEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EL
EAGS-GGI-----GITSSCYPTDGEPWGTAAVGRSRGP----------------------
---LKVNSGPNPYLR--LPAWEKGEPERRGRSATGRT------KEPPSRAV-ETGESRG-
PDNFGRRGPQR----RG--ARVPRPATTELAP----TRSPL-EAPAHQNLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDSDGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLPPDVLTEVL--GDGLSVYPSAH-MTGPPPKPRRSKKAELEG--
-P-----QPCPGPPKL----I-HSALLKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--ESG-TSQA
ESQVSGER----AYQLSISPTLLVFWNWD--VTGGWGGSLRGQVHNTKEHCMSQQSRVLL
GHPHLVYAPLGRSVMAETLIPRPSDSTDANQGSMQGRDPM------GKDPATSQ------
------SLGCSHPA---------------SSSWLQDNF---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSLPRPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGSEPGGAAPSIADTP-AALQLGELGLK------ESSE----PEGARSPRLVGGID
PEGTETELPSLGQQAASSV-----------PSCP--MLEDE---------EAE--V---F
PEGKLNMGFGDGPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVPRP-------GASLELCRKALARQRAQDLSET
ASVLLAKDKQIAALQRECRELQARLTL-------V--GKE----GPHYQVL--DFT-LCK
SHQWEVLRLQKQRDECNLSGL--L-RPPR---------PPGPPAPPR-AGAP--------
------PGAPGE----A----TLQEDVESPPVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEYEQARLSLQ--E
KQQEVQRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSTLGDRPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCSQKSSEPAS---------ATLAGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPRAEEE---AAGDELSLSPL---------PEGLGEPPAVP
YPRHLAILKQLAHSVVLA---WEPPP---EQVELHGYHICVN---GELR-QALGPGVPPK
A-VLEDLDLRA-GAL-RVSVQSLTSRGS------------SDPLRCCLVVGAQARVVPTQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPPACPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAVYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCSEVAVRTMSPH
GESADSIPAPVAPALA-VACLPARVFCPS-----PRPGSEARPPLAPASPGPGDPSSP--
---LRCPDPHGT-------REPPGGPPASPPRETP---KGSQE-EL--PAPCSQ------
-----------------EEVGAAVLGASEDRRASGPTVRETVPGPAASSLAKEEAEWTAG
E-ACPAPCS---TQEALAQR---VPSAEACCGGDTASGLRPRAEREDTA--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE--------EEEDEELGSRTCSFQKQVA---GSCIRENGAKP
---Q----PDPIWETDSDEEVLEQILELPLQQFCSKKLF-SIPEEEEEEDEE-------D
EEDKE-RPGAGCSSRDPGLPEPAVLG-LGCDSSLPR----GPGPCPLS------------
-PEPSRAG---DRLEDMPGL---VGGN-SWKRGNGS-----------PEKPPNRRRS--P
DPREHCSRLLSNC-GPQASGR----PGPTRERGAPVVGEGAKGGPEAGGRGRPAPS----
-------------R-RCPRGRA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGG-GGV-----SITSSCYLGDGEAWGTAPIGRPRGP----------------------
---LKANSGLNPYPR--LLAWEKGEPERRGRSATGRA------KEQPSRAA-ESGEPRG-
QR-----GPPR----KG--GRAPRP--TEL----APPRSPP-EVLAYQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
LVG----RQQLFQRGYLSPDVLTEGS--GHCPFVYSTAR-TAGPPPKPRRSKKTESEG--
-P----AQPSAGFPQP----V-SSASLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------SDREPG-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPADP---GT---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGSAAPRVADIPPGALQLRELRSE------ESSE----PKGTQSSRPVGCTD
SEGAEAGLPRLGQQASSSG-----------PTCL--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPFPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PQGPAPQAR-AGAPA-------
------PGAPGE----A----TPQEDVDNLPVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREVQNENARLVEENSRLSGRA--TEKEQVEWENVELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDCRTLGDRPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTTKSSEPAL---------ATLTGVPRRT-TKKAESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVELHGFHISVN---GELR-QALGPGAPPK
A-VLENLDLGA-GPL-HISVQALTSQGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPQGPWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
AESADSIPAPITPALA-PASLPARVSCPS-----PRPGPEARAPLASASPGPGDPSSP--
---LQHSGPLGT-------QEPPGAPPASPSRELP---KGVHE-DP--PAPCSQ------
-----------------GEAGAAVLGTSEERTATTSALDEKDPGPAVPSLAEQEAEWTAG
E-ACPAPSS---AQGALAPQ---GLNTEMCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHSRNSDLSDIQEEEEEE-----EEEEEEEELGSRTCSFQKQAA---GNSTRENGAKS
---Q----PEPLCETDSDEEILEQILELPLQQFCRKKLF-SIPEEEEEEEEEE--E---E
EDEEE-KPGAGCSSQDPGQPESALLG-LGCDSGQPR----GPGQCPLS------------
-PEPSRAG---DCLEDMP------GGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGWA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGS----------------------
---PKANSGPKPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGESRG-
QDGSGRRGPQK----RG--ARVPRPSIAEL----VPVRSPS-EALAYQHLPIRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAR-TAGPPPKPRRSKKAESEG--
-P----GQPCPGPPKL----I-PSADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------LDREPR-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------VEQLTTLPRPGDP---GV---
----------------------------------------------MEPWALPTWQSWSP
---GRGGEPGGAAPRIANIPPAALQLRELRSE------ESSE----PKGAQSSRPVGDTH
SEGAEAGLASLGQQASSSG-----------LTCL--RPEDE---------EVE--A---F
QKANLNMGFGDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPQP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPAPQAR-AGAPA-------
------PGAPGE----A----TPQEDVDNLPVVLGEQ--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRETQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-TKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEASRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ECVSDDDLLTSLPPELA--DFSHS-------------SGPELSF
LSVGGGGSSSGSQSSRGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVELHGFHISVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTPYQARVEA
QLPPQGPWEPGWERPEQRAATLQFTTLAAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
AESADSIPAPITPALA-LASLSARVSCPS-----PRPGPEARAPLASASPGPGDPSSR--
---LQHSAPLGT-------QEPPGAPPASPSRELP---KGVHE-DP--PTPCSQ------
-----------------EEARAVLLGTSEERTATMSTLGEKDPGPAVPSLAEQEAEWTAG
E-ACPDPSS---AQGALAPQ---GLNTQMCQGGDPGSGLRPRAEKEDMA--ELGVHLVNS
LVDHSRNSDLSDIQEEEE----------EEEEDLGSRTCSFQKQVA---GNSTRENGAKS
---Q----PEPLCETDSDEEILEQILELPLQQFCRKKLF-SIPEEEEE-----------E
EDEEE-KPGAGCSSRDPGQPEPALLG-LGCDSGQPR----GPGQCPLS------------
-PEPSRAG---DCLEDMP------GGS-SRRRGGGS-----------PEKPPSRKRP--P
DPREHCSRLLSNN-GPQASGR----PGPMRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGWA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----NITSSCYPGDGEAWGTATVGRPRGS----------------------
---PKANSGPKPYPR--LPAWEKGEPERRGRSASGRA------KEPLSRVT-ETGESRG-
QDGSGRRGPQK----RG--ARVPRPSIAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VVVDS
PAG----RQQLLQRGYLSPDIRLEGS--GNGPFVYSTAH-TAGPPPKPRRSKKAESEG--
-P----GQPCPGPPKL----V-PSADLKASHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TAQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MIQDSSTPLSGGRTSPKKPGSPGQAAAVQEEQRREMEKLRAELEEERARGRAERQRFTAQ
ARRLREVAERERQQLADHLRSKWEAQRFRELRQLQAEVQREREAEIRQLLRWKEAELRQL
QQLLGRERDGVVRQARELQRQLAQELVNRGYCGRTGTP---------EVP-AEQCRCRLQ
EVLRQLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPPDP---QAENS
SEAPLPETASN-APQ-TRKTH-LRLGPP--ASLGGRSG--------S-------------
-----P---DRQLP----A--RASSLESLDTA-YSCSLDS-T-LRRPKAFNESEAPAS-S
ANISVPDSPNSLLTK------------------VHRKRKDLR-RECSGSQPRD-SLI--S
SPPDPDYRALVKRNSELSEALQGLTRRCSELHEENLQLRCGGSPSEEDGKVKRLKMKHAE
LAGLARRLEDRARKL-QETSLRAMSAPVPG------ENRAGLELC-QALAGQRARDLSDQ
ASALLAKDKQIEELRRECHLLQAQVATGRDSPLNPAGGVP----RSEWLNI-RDLDQLQR
ESQREVLRLQKQLTLQRQ-LGCAQ--VKA-------------------------------
------------------------------SSQSVPCEES-RHQVQALELELDALRRECE
ARSAQAAAAQRRSEEAEAQLQAALQKGAWLAEENVQLQAQA--HWVRKVAAENSDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------LEQNRQQQLQHDLQKALSDLQ--A
ARKEMQALQDQPGYPP-KQPQEATQ--------------ETSRGRH------KLEPQTED
YVPSQPS---KEQ------------------SHVCPAL------------QDSTVALGEP
VNSHPV--------------SDRVP--ANQPLDSTHQAKKTSSQSS-TSSS---------
---------E-VESMWATVP-SCLTLEMDTASEVDDLEPDSMSLALEVKD----------
-PKA-PSISKFKIFQAKYS

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1157)

YNPFEGPNEHPEHELPLTAGDYVYVFGDLDEDGFYEGELED
GRQG--LVPSNLL---EQIPDNHNQRDLSPKSPESPNHLG-------------PT--LLP
VGQN--------------KAS-------------EEASLF--T-----------------
----------------------------------GEDQVSVD---RGPC-QMGREGSKTE
K-VTEILEIKR-EACWLDSSQSLQEQNF------------SIVPLK---TKELSCVGPMQ
LHLQNVTATSAEISWVYGSSRHLHVVYLNGQEHALTPSGVTCYTFEGLHPGTQYQARVE-
---VDIPWDLGQVPWETMSSTINFNTPLAGPPDPPLDVLVEHH-TLPGFLVVSWIPVTID
SAGSSNGVQVTGYAVYVDGIKIAEVSD---ATAGSILLEFSQLRVLLTCEKVSVRTMSLC
GESLDSVPAQIPEDCFTY-HSLLDSPPFGNI--------------------CGDPS----
------TFGVYH-------QK---MALSSLSNKPD----------PHTPGSCGE------
----PQGKF--------PEAL--------------PEEPLRRQPPL-SNLSSEE------
A------G-------------------------KQAQGSTGAQK----------------
------------------------------------------------------------
-------------------GCSKDLCFQKSPQNNRPLL-SRGQSVMEEN---HYG-H---
-------NST---SRGSSPGFI-H-LS---------------------------------
---PKYRPRKQLCQE---------------------------------------------
--------TAAL------------EKDCRQKQ------------------------DAQV
LT-----------------------SSQWGT-SQQ---YAADSC------NIL-------
--EEK--RCLDP--------------WHTEKREHRDKFRSQNR------------Q-HQ-
P-------S-----S---------------------------------------------
-------------------VLCPTQSSKVIKM----SRGEPPQVGPEANTPARIFVALLD
YDPLAMSSNPKA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2396)

AKEELTFKKGQLLRVWGSQDPHGFYHGECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2506)

VEGET
EQSH--RRWHLPSQGYLPSVAHLEDFEGPIS----P-----QGSFFRPP-----------
-----------------ENSRRP--TLWTPKTMIVALDYDPRDRK

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2612)

AGARAKGKLALRAGD
MVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLIPAHLLDDLSVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MKEMAEKRQQLEVDHEEALLALQ--K
KEEEVKYLQQAQIEAK-REHEDVVQLLEA---------QVRELENQYHSQTEHFNLLSQE
LEQLQIKN----------SDLMSSEL----PHSMCHSSEDCHALQCS-KNINHIEFVA--
-----------------------------TPTASKKQTKKLEFQS--NSS----------
---------K-SESIQYSP-KYFPTPEGDSASEMDEVETEKFSLS--------------L
EPER-QGPAKLQVFLARYSYDPF

PF07653 // ENSGT00390000017228_1_Domain_1 (1104, 1159)

DGPNKNPEAELPLTAGEYVYIYGDMDEDGFFEGELMD
GRRG--LVPSNLI---EE

ENSGT00390000017228_1_Linker_1_2 (1159, 1262)

VSDDDLMTFVPPKTS--NLSCA-------------SDHEMSF
LSRSAS--------SGEKSEDEEI-----------LVSLL--LNRLEGDMEMPDDHVAVP
C

PF00041 // ENSGT00390000017228_1_Domain_2 (1262, 1362)

PRNLTLIKQFTGSVVIF---WEPPLMPAGWGDVQSYNIYID---TELY-QNVRSGCQTQ
A-TIENLDLKF-KSY-RISVQSVTEKGN------------S

ENSGT00390000017228_1_Linker_2_3 (1362, 2335)

DKKQCTFLVGHGFHIAPAL
LKLRSVTATSAEVTWLPSSSNYTHAVYLNEKEYDVTKEGIYWYTFYNLQPNTQYKARVET
K-PQKLLWDLPQEEWEQKSSMIKFITPSVGPPDAPLDVQVQPG-HSADILVISWIPVTID
AAGSSNGVQVTGYAVYVNGQRVTEVMS---PTAGSAILELSQLKMLPGSQRVSVRTVSPN
GESVDSVPALIPSAVLNVPCCSSSLKSLS-------------TSLNSELL-YGELIDSQN
VKNSFMHFMSSP-------S--------SEM--------------------CMAS-----
----QDEKF--------TIHFASNCGDSV---ASLPASI--PTHQ-----------FSSQ
S------SS-------L-----------INELAMCNTGDNVARDK--------DDNCLKS
YQT-AVSVQPVD--------------LVFPSRWYEESVNSSMPTLKELSEDSQRKRVKKL
-------FVT--KKAVLENQTVTSNVKMSMTTQCVHPDDKSVKDS---------------
------------------------------------------------------------
-TTQDIEGYDESCLSSVPQLCSSQL--------ELE---------------EECYRDIG-
-IQGICVQEIPDVSTE-----KKQMKELSKED--------PSLGMPRSE---IQEDQTSR
TGNWQL-NP-------------------VG--DHS---HSSDLSD------ILEEEEEDL
DLNMQEENI------------------------------------------------LK-
MAGNDNS--LTELPE-FPMQWVA-QN-RNMSKSL--------------------------
--RVGQAGTSSF--------------SKTGP------LKSFVSEEIVNDDSLRM

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPISMSPNLDAAEEELAFKKGQILKVVGDKDDDGFYRGEYAGRVGYIPYNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VHVER
NEM----KQHLLKQDSVTDEKSVSNLVEVDAQNN--------------------------
-----------------SKSVSE--HSLQDRT

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2614)

MVAVCDHNPGENSLNANVEGVLTFSVGD
IITVFGSVDDDGFYY---------------------------------------------
-------------------GEFNGQRGFIPSDLLTAISWDEE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRLGDL---GA---
----------------------------------------------MEPWALPAWQHWTQ
---GQGCKPGDASPSIAGTP-TALQVKGLRSE------ESSK----PEGAHSPGPVGNTD
PEATETGLPKLGQQAESPG-----------YSCS--RLEEE---------EAQ--A---Y
-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLSL-------V--GKE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SPGPTAPSR------------V
GAPA--PGAPGE----A----VLQDDVESPQVVLREP--EKQQRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENSELKGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSALGDHPPPHCCCSI---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------TTLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNS-----PTPEVDTASEVEELEVDSVSLLPA-A-----------
-PESHSGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLSTLPRELA--DSSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRHITVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLRT-GPL-HVSVQALTSKGS------------SDPLRCCLAVGAGAGVVPSQ
LRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESSDSIPAPVAPALA-SACQPARMSCLS-----PRPSPEVRTPLASVSPGLGDTSFP--
---LRHPVPHGT-------QDFS----ASLSIEMS---KGPQE-EP--PVPCSQE-----
------------------EAGAAVRSISEEKRAIEPTLGQEGPEPVAPSLAKQEVECTSG
D-AGPVPCS---TQGELTQK---KPSIEACHGGDLDSGLKLRSEKEDMS--ELGVHLVNS
LVDHSRNSDLSDIQEEEEEE-------EEEEEELGFRPCSSQKQVA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQRLCSKKLF-SIPEEEEEE---------EE
EEGLE-KPGPSRTSQDPSQPELALLG-PGCDSSQPQ----GPGLCPLS------------
-PELSGVR---EHLEDVLGV---VGGN-SRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQASARPV----PPRERGSLPVIEGTRVGQEPGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----NINSSCYPTDGEAWGTAAVGRPRGP----------------------
---PKVNPGPNAYLR--LPAWEKGEPERRGRSAIGRT------KEPPSRAT-ETGESRG-
QDNSGRRGPQR----RG--ARVPRSGTTELAP----PRSPQ-EAPTHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFKEGQLLKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PSG----RQQLLQRGFLPPNVLTEAS--GNGPSVYSSAH-TPGPPPKPRRSKKVELEG--
-P----TQLCPGPPKL----I-HSAAQKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPESGS------L--ESG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------TQREREAEIRQLLRWKEAEMRQL
RQLLQRERDGVVRQARELQRQLAEELVSRGYEV-----------------SAAQCRCRLQ
QVLAQLRWETDGEQAARIRHLQTALDVERQLFLKYILEHFRWQPVVSEASDS--SQNLRP
LQERLPGPANG-ACR-TPKLA-CRLGSL--DSLSSGAR--------ARSRSLDLVPA---
---AGSSSPDDLFP----T--RASSLDSLAPA-RSRSHDSST-PSGPKA-SESEARASSS
TDASILGSPLPP-----------------PPALAHRSPSDPR-GESPGGQPCE-APTSAP
SPPDLGYHELVKQNSELTEALRVLARRCSGLQEENTQLRRAGFPVQAAEKVRRLQVKRAE
LTGLARRLEDRARKL-QETNLRAMSAPVPG------QSYADLELC-QAFARQRLQDLSEQ
ASALLAKDKQIEELRRECHLLQARVASDLGGATHPAGGAP----CAQWLGI-SDLDRLQR
ESQREVLRLQRLLTLQRGQ-SGAR--AEG-------------------------------
------------------------------GGQSGPCEEEARHQVRALER-------ECQ
------------EQEAEAQLQAALREGAWLLWKGGGGKAATPPGFVGEKIFLN---RGAT
G--E---------------------------------GAKKRQLGQQSLKKAFRGNSRVA
EKGRCRTLKVQPGQPFPKRPLEKSQ----------------GSQKI--------KKAPP-
--SPISGFKPQGK--------------------KKASV------------QESPVAIGET
ARASQE--------------LATAP--ASPALGSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCPTLDMDTASEVDDLEPDTVSPALEVGG----------
-AKA-PATPNFKIFLARYSYNPFEGPN

PF07653 // ENSGT00390000017228_1_Domain_1 (1108, 1157)

EHPEGELPLTAGDYVYIFGDMDEDGFYEGELGD
GRRG--LVPSNLV---EQIPHSDILGCLSPKSP----DLG-------------PL--QIP
AAQG--------------KAA-PK-----------ADSLV--P-----------------
----------------------------------AEALGAAG---PGPR-RTKNTDSKTK
V-A--------AETCQTGLPQSLGEQGF------------SRPLPG---AKGVLCVAPKQ
LRLQSVTATSAEIAWICSSSNHPHVVYLDGQEHALTPAGVSGYTFQSLHPGTQYQAWVE-
---VRLPWDLLQVLWETMSSIITFDTPLAGPPDPPLDVLVEHHHGSPGCLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVAEVPD---ATAGSTLLEFSQLQVPPTCQKVSVRTTSLF
GESSDSVPAQIPEDHFTC-HQLPETPPFSYT--------------------CGDPSTC--
----RVTFPVCS-------QK-------PLNAKAN----------SYTPGSCGE------
----PQAKF--------LEAF--------------SEEPPKRPSPM-SNLSSDGERLSSR
A------G-------------------------RRSHGFAKARE----------------
------------------------------------------------------------
-------------------GCRQHLLFQKHPRGHRSPL-PSGRSGREEN---QYR-H---
-------RGP---GKCPAPGVI-H-LF---------------------------------
---PEDEGRKEPEQE---------------------------------------------
--------KSFL------------QKALGQKQ------------------------DAQG
FT-----------------------PPQLGP-SPC---FPTDFQ------DI--------
-----LAGYMDL--------------WDTERQEQRKEPRLQTK------------Q-GQ-
APGGKRE-----------------------------------------------------
---------------------CPAPSSNAIKM----SRGGR--VGAGPNTPARI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YNPLVMSSNPETAEKELSFQKGQLLRVWGPQDSHGFYLGECDGRVGNIPGHMVA

ENSGT00390000017228_1_Linker_3_5 (2395, 2506)

EAAVGT
EWTD--GRWHLLSSGCALSLAHLEDFKGLAS----A-----QGALSMLQ-----------
-----------------GDSRRT--PLWAPKTMMAALDYDPKDGR

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2611)

AGGRAKGKLALRAGD
VVTVYGPMDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHISLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----MHCRKALGEAA-----------EETLAPSKKNLSHRPSAF--HSAIQEAKGLQSH
LEDLELELKAVKEVHGNSC-ECCFLSEDGPESESGGSAVERLSFT--------------L
PSPG-QVSPMLRRFLACRSYD

PF14604 // ENSGT00390000017228_1_Domain_1 (1102, 1153)

PFEGPNEDPESELPLTAGQYVYVFGDVDENGWFLGELTD
GTRG--LVPSNLV---AEVSDDDLDTTLPPKLR--DLLLD-------------TDG----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGQSQPRPEEE---NAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPLASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EETGAAVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGAMAQQ---APNTEACQGGDPESGLRPRAEKEDAA--ELGVHLVNS
LVDHGRSSDLSDIQEEEEEEEEE--EEEEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSKAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSTELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPAPQTSQGG------LSQSRA-GGWA
RNPQE-VW----WNGTGHLPGQWFWPQ---------------------------------
--------------------------------LFPRGIRV------------EG------
---------QS------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWHSWTP
---GRGGEPSSAAPSVADTPPAALQLQELRSE------ESSK----PKGDGSSRPVGGTD
PEGAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GTSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPL-PPSW---------PPGPALQAR-AGAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGSLGDCPPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDELSLSPS---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PHPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPASSS---TQGALAQQ---APNTETCQGGDPGSGLRPRAEKEDTA--ELGVHLVNS
LVDHGRNSDLSDIEEEEEE-E------EEEEEELGSRPCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEE-----------E
DEEEE-KSGAGCSSRDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PESSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----LGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTANVGRPRGP----------------------
---PKANSGPKPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETGEARG-
QDGSGRRGPQK----RG--VRVLRPSTAEL----VPARSPS-ETLAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS--GNGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSADLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVY----HIPAPQTSDRG------IGKEPS-GSPE
EWNGSPPW----TVVLA-----PAVPQGHQSRGAG-PEPLS-------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRLGDP---GA---
----------------------------------------------MEPWALPAWQHWTQ
---GQGCKPGDASASIAATP-TALQVKGLRSE------ESSE----PAGAHSPGPIRNTD
PEGTETVLPKLGQQAESPG-----------YSCS--RLEGE---------DAQ--A---Y
-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRESKMPLCPD-------PDPVWSCRKALARQRARDLSET
ATALLAKDKQIAALQRECRELQARLSL-------V--GKE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SQGSTAPSS------------V
GAPA--PGAPGE----T----VLEDDVESPQVVLGEP--EKQLRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGKA--TEKEQVEWENAELKGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEEEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCNALGDHPPPHCCCSS---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGHSGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLSTLPRELA--DSSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---ATGDELSLSPP---------PEGLGEPLAVP
YPRHITVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAMGAGAGVVPSQ
LRIHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QIPSQGPWEPGWERPELRAATLQFTTLPAGLPDAPLDVQAEPG-PSPGIVMISWLPVTID
AAGTSNGVRVTGYAVYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESTDSIPAPVAPALA-SACQPARMSCLS-----PRPSPEVRTPLASVSPGLGYTSLP--
---LRHPVPHGT-------QDSP----ASLSTEMS---KGPQE-EP--PVPCSQE-----
------------------EAGSAVHRTSEEKRAMEPTLGQEGPDPVAPFLAKQAVECTSG
D-AGPTPCS---TQEELTQK---EPSTEVCHRGDLDSELKLRSEKEGMS--ELGVHLVNS
LVDHSRNSDLSDIQEEEEE--------EEEEEELGSRPCSFQKQVA---GNSIGENGAKP
---Q----PDPSCETDSDEEILEQILELPLQRLCSKKLF-SIPEEEEEE---------DE
EEGLG-KPGPSSSSQDPSQPERALLG-LDCESSQPQ----GPGLCPLS------------
-PELSGAR---EHLEDVLGV---VGGN-SRRRGGCS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQTSARPV----PPRDRGSLPVIEGTRVGQEPGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EVGS-GGV-----SISSSCYPTDGEAWGTAAVGRPRGP----------------------
---VKVNSGSNTYLR--LPAWEKGEPERRGHSAIGRT------KEPPSRAT-ETGESRG-
QDNSGRRGPQR----RG--ARVLRTGTTELAP----PRSPQ-EAPSHQDLPLRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPISMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDT
PIG----RQQLLQRGFLPPNVLTQGS--GNGPSVYPSAH-TPGPPPKPRRSKKVELED--
-P----AQLCPGPPKL----I-HSAALKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--DSG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQPTPLPRPGDP---GN---
----------------------------------------------MELWALPAWQSWTP
---GQGGEPGGTSPSIADTP-AALRVGELRPE------ESSE----PEGARSPGSVGGIQ
PERTTTGLPSPGPGALSSG-----------LSCQ--RLEGK---------EVE--A---F
SKGKLKMGFGDRPNLELLRAVGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKX----XXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-XXXX---------PPGLAGRTR-A-----------
GAPA--PGAPGE----A----TPQEDVENPPVVLGEP--EKQQRVQQLESELNKKRKKCE
SLEQEARKKQRRCEELELQLREAQSENARLVEENSRLSGRA--TEKEQVEWENVELRGQL
L--GVTQERDSALLKSR--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLRLQ--E
KQEEVRRLQQAQAEAQ-REHEGAVQLLE-S-TLDSMQVRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGYSTLGDRPPPPC-CST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLAGGPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLPPA-A-----------
-PEGSRGGARIQVFLARYXXXXXXXXXXNPEAEASLTAAKYIYIYN--DEDGFFEGELMD
GRRG--L-----VSNVERVSDDDLMTSLP-ELA--DLSHS-------------SGRELSF
S-GGAGGSSSGGQSSGGRSQPRTEEE---AAGDELRLSPS---------PEGLGEPPAAP
HPRRLAVLKQLAHSVVLA---WEPPP---ERVELRGYHVCVN---GELR-QALGPGAPPT
A-VLENLDLQT-GPL-RISVQALTSWGG------------SDPLRCCLVLGAGAGVAPSQ
LRVHRLTATSAEITWAPGNSNLAHAIYLNGEECPSACPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGLERPEQRAATLQFTTLPAGPPDAPLDVQVEPG-PSPGILLISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQACRAVAVRTMSPH
GESADSIPAPVAPALA-EASSPARVSCPS-----PRLGSEARPPLAPASPGPGDPSSP--
---LRCPNPRGA-------REPPGGSPASCPGETP---KGSSE-EP--PVPGSQ------
-----------------EEAGAAELGAPGDRKASEPTSGERVPGPAASSLAEEKAEWTVG
E-ARPAPGS---TQGALAQR---LPCAEACRAGDTGPGLRPRAEREDTA--ELGVRLGSA
LVDHGRNSDLSDIQEEEE----------AEAEELGVRTCSSPTQGA---GNSLRDNGAQP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDE---------
-EDEK-RRGAGSSSRDPDPPEPAFLG-LGCDSGRPR----GPGLCPLS------------
-PEPSRAG---DRLEDLPGL---VGGS-SWRKGSGS-----------PEKPPSRRRS--P
DPREHCSRLLSNG-GSQASGR----PGPARERGGPPVGEGTRAGPEAGGRGRPAPS----
-------------R-RCPRGPA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
ETGG-GGV-----SGTSSCCLGDGEAWGAAPTGRPRGP----------------------
---PKANSGPNPYPR--LPAWEKGEPERRGRSAAGRA------KESPSRAT-ETGEPRG-
QNGSGRRGPQR----RG--GRAPRPGSAEL----APLRSPPEEALAYQDLPVR

PF07653 // ENSGT00390000017228_1_Domain_3 (2334, 2396)

VFVALFD
YDPVSMSPNPDAGEEELPFQEGQILKVFGDKDADGFYRGEGGGRMGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VTADS
PAG----RQQLLQRGYLSPDVLVEGS--GNGPFVYSTAR-TAGPPPKPRRSKKAESEG--
-P----AQPCAGASQP----V-SSTGLKAPR

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2616)

SMVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------EELNGQRGLVPSNFLESPGREAGG------SDREPG-TPQA
EGQPWASS----TQGPP--------------APPGWPCAPGPGRFSGIE-----------
-------------------WGAPQGPSKKVWGLLSKGKQLLRKLGSGKKE----------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------VQREREAEIRQLLRWKEAEMRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCCRTGAP---------EIS-AARCRCRLQ
EVLAQLRWETDGEQAARIRHLQAALDVQRQLFLKYILEHFRWHPALSGPADA---PAVHS
SEEPLLKISS--TPH-TPKPA-CRLESL--DGLSAGVR--------ARSRSLNLMSS---
---MCSSSTSGLLS----M--RASSLDSLAPE-RSRSVDS-T-LSRPKA-SVHNERAS-S
SDTSILGSPVPSSP-PPLPPP---T-LP-PPSSPPGKPSDPRGGEGPNSQPCE-ALS--P
SSSGLDYHELVKQNSELAEALQVLARRCSDLHEENLQLRRAGFPDRSDEKVKRLKVKHAE
LAGLARRLEDRARML-QETNLRAVSAPVPC------ESRSILELC-QAFAHQRAQDLSEQ
ANALLTKDKQIEELRQECHLLQARVASGLDSNLNSGEGSP----SAQWLKV-SDLDRLQR
ESQREVLRLQRQLTLRQGC-GGAR--AEE-------------------------------
------------------------------GVQSAPCEEA-RRQVQALERELGARQRECE
ELGAQAAAAHRRGEEAEAQLQVALRKGAWLAEENGRLQAQA--NWVQKVEAENSDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------SGQDRQQQLEHDLQKALCDLQ--A
ARKEIQALQCQSNHPA-EQPGEATQTLET---------QTRNSRRP------KFQPGPED
HTLSQPSRDQQEI--------------------REASP------------DVSPVALGEP
TSAPHM--------------PDRVI--ASPPLDSRPQAKKTSSQS--NSSS---------
---------E-VESIWATVP-SCTTLDVDTASEVDDLEPDSMSLTPEVGG----------
-SDA-PAAAKLKIFLAQY

PF07653 // ENSGT00390000017228_1_Domain_1 (1099, 1157)

NYNPFEGPNEHPEGELPLTAGDYVYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQVPDNNIPGYLPPKSP----DLG-------------HS--PIP
AGQD--------------KAA-KE---------D---SLL--P-----------------
----------------------------------GEAQGVVG---RGPS-QM-GLGSIAE
V-ATDILHTKT-EAYQLGLPHSTQEQGF------------SRPFLG---ANGLLCVAPMQ
LHLHNVTATSARINWVYSSSSHPHVVYLDDQEHALTPAGVSCYTFHGLHPGTKYHTRVE-
---VQLPWDLLQVHWETVSSTITFDTPLAGPPDPPLDVLVER-HTLPGFLMVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVSEVAD---ATAGSTLLEFSQLQVPLMCQNVSVRTMSLC
GESLDSVPAQIPEDCFPC-HQSLETPPFSYA--------------------CGNPVSC--
----RVTFPICP-------QK---LALTPLSAKAS----------PYIPGSYGE------
----PQTKF--------LEAF--------------SEESLRRQSLM-SNFSSEGQCPSSG
A------G-------------------------IQAQGLVEARE----------------
------------------------------------------------------------
-------------------GCQKDLLFQKARQNHRPPL-LNVQPRGREN---CYR-H---
-------MGT---RKSLAPGFV-H-LS---------------------------------
---PECGPWKEPCQE---------------------------------------------
--------KPAL------------EKAFRQKQ------------------------DTQV
FT-----------------------PPQLGT-SQQ---YASDFC------TILEE-----
-----EAVCLDL--------------WPPEEREQRKELGPQSR------------R-GQ-
ALGSKRECQLHKLSL---------------------------------------------
-------------------APYPAPSRQVIMM----SRAGPLQSGVGAEPPARVFM

PF07653 // ENSGT00390000017228_1_Domain_3 (2337, 2395)

ALFD
YNPLMMSANPEGVQEELAFQRGQLLRVWGSRDPLGFYHGECNGQMGTIPGHLVA

ENSGT00390000017228_1_Linker_3_5 (2395, 2510)

EVEEGM
EWTD--ERWHVWAQGHQPSVAPLDDSGGLTS----P-----QDSSPIPQ-----------
-----------------GNSRRA--PLWTPKTMMAALDYDPRAGGAGTR

PF07653 // ENSGT00390000017228_1_Domain_5 (2510, 2614)

AKGKLAVKAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAYLLDHMSLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLRELRAE------ESSE----PKGAGSSGPIRGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GHLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSNSGGQSSGGRSQPRPEEE---DAGDQLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------EEPPGAPPASPSREMP---KGSHE-DP--PVPCSGR---G-
---------------EQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEVCQGGDLGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEE--------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--A
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRPGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GNI-----SITSSCYPGDGEAWGTATIGRPRGP----------------------
---PKANSGPKPYPH--LPAWEKGEPERRGRSATGKA------KEPLSRTT-ETREARG-
QDNFGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDS
PAG----RQQLLQRGYLSPDILFEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSAELKAPRSMVA-------ESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLLGRVYH----TPAPQTSQGG------LSQSRA-GGWA
RNSQE-VW----RNGTGQLPGQWFWPQ---------------------------------
--------------------------------LFSRGVRV------------EG------
---------QS------------------------------------

------------------------------------------------------------
--------------------------------------------------------MRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGYCGRAGAP---------EAA-AAQCHCRLQ
EVLAQLRWETDGEQASRIRHLQAALDKERQLFLKYILEHFHWHPALSGSPDP---QAVHS
SGEPPPETAGA-SRD-PPKSA-CRLESLD--SLSSG------------------VPA---
---ACSNSPDSLLP----T--RSSSLDSLAPA-RSHSLNS-T-LSRPKA-PESEERASSS
PDASIVGSPSPPPPPPPPPP-----PPPPPPPSEHRRPRDPRRGEEARKQPCG-APT--P
LPPGLDYHELVKQNAELSDAVQVLARRCSGLREENMQLRRAGFPEEANEKVKRLKVKHAE
LTGLARRLEDRARKL-QETNLRAVSAPVPG------ESRAGLELC-QAFARQRARDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGVSSALHSGGIAA----RTQGLSV-SDLDRLQR
ESQREVLRLQRQLALQQGT-VGAR--AEA-------------------------------
------------------------------GGQSAPCEEA-RRQVQELERELGARRLECE
ELGAQAAAARRRGEEAEAQLQAALREGAWLAKENARLQAQA--DWTQKVAAENNDVRGQL
G--RACQERDAAGLLAE--QLLQQAA----------RGQDRQQQLQHDLRKALSDLQ--A
AREEMWALQCQPGHPS-QEPQESPQTVEY---------QVKGSGRT------KFKPGPED
QASSQPSRDKQEK--------------------KEASL------------LETPVALGEP
ATAPQV--------------PDRVL--ASQPLDARPQAKKTSSHL--NFSS---------
---------E-VESMWATIQ-SCPALDMDTASEGEDLEPDSVSSTLEAGD----------
-SEA-PTTPKFKIFLAQYSYNPFEGPNEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPLTAGDYVYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSDILGCLPPEAA----DLG-------------PT--RLP
AGQT--------------KAL-KE---------DAGHSLL--H-----------------
----------------------------------GKAQEAVD---RGPC-QMVWAGSKTE
A-AIEISDAKT-EHGRLGLQQSVEEEGF------------SRSLLG---ANGALCVAPMQ
LHLQSVAATSAEVTWVYSSSSHPHMVYLGDQEHALTPAGVSSYTFHNLHPGTRYQARVE-
---VRLPWDSLQVLWETMSSTITFDTPLAGPPDPPLDVLVER-HASPGLLVVSWLPVTID
SAGSSNGVRVTGYAVYADGLKVAEVAD---ATAGSTLLEFSQLQLPLMCQKVSVRTMSLC
GESLDSVPAQIPHDCFTC-QQLPETSPFSYT--------------------C--------
-----VTFSFCP-------QR---LALSSLSAKAS----------PHIPGSCGE------
----PQAQF--------LEAL--------------PEEPPRRRSPM-PDLSSEGEWS---
-------G-------------------------RQAQGPADTQE----------------
------------------------------------------------------------
-------------------VYRKDLLFQKSPQNHRPPL-PSGQPVGEED---HYQ-H---
-------MGT---SQSPALGVV-H-LS---------------------------------
---PECGPGKEPCQE---------------------------------------------
--------KAAL------------EKVLRQKQ------------------------DSQR
FA-----------------------PPQLGT-SQR---HVSDFC------DI--------
-LQEEAAVCFRP--------------WGTERREQKKELSTQSR------------R-GQ-
ALGGKRD-------S---------------------------------------------
-------------------ALCPAPSSKVIKM----SRGGPPLLGTGVDSPAKLS

PF07653 // ENSGT00390000017228_1_Domain_3 (2336, 2396)

VALFD
YDPLVMSANTEAAEEELAFQKGQLLRAESSQDTHGFYHGECNGQVGHVPGQLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2498)

VEGCM
EQTD--GRWHLPAQGHLPSVAHLDTLGEVTN----P-----QSSFPMPQ-----------
-----------------GNPRRP--PLWTPMTMMAAL

PF07653 // ENSGT00390000017228_1_Domain_5 (2498, 2611)

DYDPKDERAGGPVKGKLSLRAGD
VVKVYGPVDDKGFYY---------------------------------------------
-------------------GESGGHRGLVPAHLLDHMSLHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGNP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAVPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEV----GRLEARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPAPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEE----------EEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LGCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWVTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSG--NGPFVYSTAR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSAELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2607)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------VRTLMGRVYH----TPAPQTSQGG------LSQSWA-GGWA
RNPQE-VW----WNGTGHLPGQWFWPQ---------------------------------
--------------------------------LFPRGIRV------------EG------
---------QS------------------------------------

MTKDSPTSVGGGRASPKKPGSPGPAAAVLEEQRRELEKLRAELDAERARGRAERRRFATQ
ARQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVHREREAEIRQLLRWKEAELRQL
QQVLHQERDGVVRQARELQRQLAQELVNRGYCGRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQASRIRHLQAALDAERQLFLKYILEHFRWQPALPEPADP---QAAHS
LGEPPLKAQSN-TRG-TSKPA-RRLGSL--ESLRTDVR----------------------
-----VSSPDDLLL----T--RASSLESLASA-HSCSLDS-T-RSCSRA-SESEVGAP-S
TSASNPVTSSPPPPPQ----------LPS----IHRKPSDLQ-GESSENKPCE-APT--L
SPPGQDYQELVRQNSELAEALQVLVRRCCDLREENLQLRCTDFSDETDEKVKWLKVKHSE
LTDLAQRLEDRARKL-QETNLRAASAPVPG------ESLEGLDQG-QVFASQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQAHIAADLGSSSLPGEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AR--AEA-------------------------------
------------------------------GSLSSPSEIA-RYQVQALEQELGAQRRECE
ELSAQAAAAERRYKEAEAQLQAALNKGARLSEENARLQALA--SWVKKMADENSNVPRQQ
NHSRQRQDLEATGLLAE--QLLQQAE----------YVQDGWQQLQYYQNKAPGDPL--P
SGKETQGLQCQPGHPL-ET-TETTQASES---------QTRDSRRP------KFKPKSEE
HALSLPTRDTE-P-------------------PVCLSQ------------QENSVSLGEP
TGMPQV--------------SEKNS--ISQPLDSRPQAKKASSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDNVSSPLEMKS----------
-SET-PATPQLRVFLARH

PF07653 // ENSGT00390000017228_1_Domain_1 (1099, 1157)

NYTPFEGPNEHSQGKLPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSSLV---EQISGSHILSHVRPKSP----DMS-------------PT--ALP
PEQT--------------HAL-------------KKGSLS--L-----------------
----------------------------------GDAQGSLE---RGLC-QVGRTDSKTD
V-AAEILETKT-EACWLGLKPSMEEQTV------------SRPLLE---AKGVFYLAPMQ
LQLQNVTATSATITWTSGSNRYPHVVYLEDEEHTLTPSGVSCYTFQGLHPGTRYRVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEQH-ASPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLMELSQLRVPLTCQKVSVRTMSLY
GESLDSVPAQIPEDCCSY-YPFLDTPPFSYT--------------------DGDP-----
-------ST-CR-------V-------VSLSTKPS----------SHTPGSCGE------
----PQAKF--------LEAF--------------PEELPRKHLPV-SSLSSEG------
A------D-------------------------NQVQGPTGSWK----------------
------------------------------------------------------------
-------------------DYEKGLSLQESPQNHKPPL-LFGHSGVEEG---HSP-H---
-------MCI---SGCPAPGFI-H-LS---------------------------------
---PETGPRKVLCWE---------------------------------------------
--------KAGL------------EKA-LQKP------------------------YAQM
LP-----------------------PHQQDS-SQY---PTADFH------HVL-------
--EEEAAVCMDS--------------RCTEKLGQRKNKF-QSG------------Q-RRE
TPGGKRE-----------------------------------------------------
-------------------SLCPVPTSKVIKM----AGGIPEQLETEANNLVRVFVALFD
HSPLVMPVNAKSA

PF07653 // ENSGT00390000017228_1_Domain_3 (2354, 2395)

DEELVFRKGQLLRVWGSRDPHGFYHGECNGRVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2498)

EVEVGT
EQTD--RRWHLPVQGHLHSEAQHEDLAGLTN----S-----QGPL-MPQ-----------
-----------------GNSRTP--TLWTPKTMVAAL

PF07653 // ENSGT00390000017228_1_Domain_5 (2498, 2614)

DYDPRDGRAGVRAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDELPVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------LS--NSSR---------
-----------SESLLNSP-KSCPTSEVDTASEMEELDSDSISLLQD-------------
--ARGPGAAQLQVFLARYSYDPFD

PF07653 // ENSGT00390000017228_1_Domain_1 (1105, 1157)

GPNENPEAELPLTAGEYIYVYGRMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLPAGPGEPG--ETSQS-------------SGPQLSS
PAGGGGGGSRNELLVRRSLH-----CQRLLRSDTILLSPLPLYSFRED-------LPSAY
LPASDFLAKFLPHLLFLKGNRREPFPLRIIHSSFLSY-ENPN---YELR-RSLEPGAPTK
I-TLEAPEPRD-RPH-RISVQSVMGRGSPDPRPCRDPPRCSDPLRCSLLVGPGAGPAPRQ
LGLRRLTATSAEISWLPGSSSYAHGIFLNGEECPPAPPGTYWASFTNLRPRTPYQARVEA
RPPGTGPRELGWERREPRTATVQFTTPAAGPPDAPLDVQVEPG-PSPGILAISWLPVTID
AAGSSNGVPVTGYAVYADGQKVMEVAS---PTAGSVLVELSQLQLLRRCQAVCVRTMSPV
GESADSLPALIQGLSAPVPAAPFSGSSPA----TPRVSWADPDPDPAPAPGPGLRAQG--
---LVPLSHLGAR-GPVSCQGPT-G-----PQRGP---PGSQDTR---------------
SQVGVGDAR--------EESGWVAQ----------EEGGPQDRVPPAPTLLPSQEEQGNG
SDGGLAESP----EG---SR-G-RPGNQRSRDADPLRGLCPRIQKEE-AVQELGARLANP
LPDHGRSSDLSDILEEEEEEEEEEEEEEEEEEQEEQEEQS----LA--LGP-L-------
EPGGPWE-EDDTCEMDSDEEALEL---LPPQKFCSKKLF-SIPEVAEEEEEEEEEKEEEE
EEEEEEEEEEE----EEKVMEQ--TG-LGE----------RPQDSPPA------------
-PRPSCRG---L---RVPGLG-VIQAWESRTSQGQSP-----------RWPGA--GVRDP
RGHEDCGRGLRGAT--------RARGGPWREKGDLLAGEEVKAGAETTDRAQPGPSK---
---------RG------PRSSG---PAPPRF-SSNSGPLCLEMG------IEYDSEE-DG
LESG---LEPGVLLPRA---RGTQEGLVPEREDRPHGGCGR-----------RRGDGG--
---PRETPNPSRCRRLCCRDWGEPGNPRRACSPDGREPVWSRAKRPFPSAP-TS------
GSGASLQGHLG----RG--MLCLRPCCAEL----PPPRSPVPEASPPRAGAARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFKEGQVLTVWGEKDADGFYRGECGGRAGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2494)

VPVQS
GSR----RRRPPALASDLSDSLAEALETGNGPSSFC----LAGPPPKPRRSKKGEGHGPY
LGQRMFTLPCPSCPGT--CPAPGWAGPCPPQTV

PF00018 // ENSGT00390000017228_1_Domain_5 (2494, 2611)

VAAFDYNPQESSPNVDVEAELSFKAGD
VIMVFGAMDDDGFYY---------------------------------------------
-------------------GKLNGRQGLVPSNFLEGAVGLGQP------------QESVA
MNQRMRKR----RVQR--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKSGSPGPAAAVVEEQRRELEKLRGELEAERARGRAERRHFAAQ
ARQLRESAEQERQQLADHLRSKWEAQRFRDMRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHRERDGVVRQARELQRQLAQELVSRGYCGRAGAR---------EIA-ATQCRCRLQ
EVLAQLRWENDSEQAARIRHLQAALNLERQLFLKYILEHFRWQPALPGSLDS---EAVPP
SEDRLTGAGSS-ARC-TSKPP-CRIGSL--DSLSDGVR----------------------
--------VHDLLP----T--RATSLGSLATA-RSCSLDS-A-LSCPKA-PESEVRAS-S
TDSSIPSSSSP----S----------LPPLSSPAHRKPNDPGGGEGSGNQPCE-ALT--P
SPL--DYNELVKQNSMLTEALQVLSRRCSGLRQENMQLRRAGFPDQTDERVKRLKVKHAE
LTGLARRLEDRARKL-QETNLRTLSAPVPG------ESRADLELC-QAFARQRTRDLSEQ
ASALLAKDKQIEELQRQCHLLQARVATDHGSASHPEGGAP----RAPWLNI-SDLDRLQR
ESQREVLRLQKQLTLQQQCNGGAG--AEA-------------------------------
------------------------------SGQSSPCEVA-PNQVQALERELDARRRECE
ELNALAVAARRQGEDTEAQLQAALHKGAWLAEENARLQAQA--DWAQKMAAENRDVRGQL
G--RVGQARDASDLLAG--QLLQQAE----------HGQDRQQQLQHDLQTALEDLQ--A
AQKERQALQSQPGHLP-QQPQETSQVLES---------QALGSEKP------KFKPGPED
RALSLPNRDKQKQ------------------PSVCLSL------------QEKPLAFGEP
ATAPQM--------------SDKDS--TSEPLDSRPQAKKTSSQS--NSSS---------
---------E-MESVWATVP-SCFTLDRDTASEVDDLESDSVSASLEEGV----------
-SEA-PTTPKLKIFLARYSYNPFEGPNQH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYVYVFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPNSPNLDCPLLKAP----DLS-------------PS--ALP
AKQG--------------L---------------KKENLS--F-----------------
----------------------------------GEAQVSID---KG-----------SD
I-AVEMLEKTT-ETCWLGSPQSVEEHGS------------SIPFLE---AKGGLCVAPMK
LHLQSVTATSAEIAWVYGSSRHPHMVYLDDQEHALIPSGVSCYTFQGLHPGTRYQVQVE-
---VRLPTDLLQVLWETMSSTITFNTPLAGPPDPPLDVLVEHH-ASPGFLVVSWLPVTID
SAGSSNGVQVTGYAVYADGCKVAEVTD---ATAGSTLLEFSQLQVPLTCQKVSVRTMSLY
GESLDSVPAQIPEDCFTY-HSLLETPLFSYI--------------------C---I----
------NFPVCH-------QQ---LTQASLNTKTS----------PYTSKSCEQ------
----PQANF--------LEVS--------------REVSSRKPSPM-SSVISKG------
A------G-------------------------KQAQGPIEAKK----------------
------------------------------------------------------------
-------------------DCGKSLPFQKSPYNHRLLL-PTG-----KS---QYQ-H---
-------MSN---SRSSASGFS-H-LS---------------------------------
---LEHGPREEPCQE---------------------------------------------
--------KAPL------------EKALKQKH------------------------NGHM
FM-----------------------PPQKGI-NQK---YATNFH------TVL-------
--EEKEVECWDP--------------WHTGKPDQRKTLKPQSG------------Q-GQ-
ALGDKRECC--EPDL---------------------------------------------
-------------------VQCPAPSTQVIKM----SRVSSSLPGSEANTPARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2395)

FVALFD
YNPLVISSNPQAAEEELAFQKGQLLRVRGSQDPHGFYRGEYNGKVGNIPGHLVM

ENSGT00390000017228_1_Linker_3_5 (2395, 2493)

EVETGT
ELTD--GKWHLSTQGH------FEDFERLTS----P-----QGSFVMPQ-----------
-----------------GNSRSP--TLWTSKT

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2612)

MVAVLDYNPRDERTGARSKGKLTLRAGD
MVTVYGPVDDKGFYY---------------------------------------------
-------------------GESSGHRGLVPAHLLDDLSVHAK------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLPELRSE------ESSE----PKGARSSGPIGGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQ---------------------------ARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGTLGDRPPPPCCCST---PRPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRSQPRPEEE---DAGDDLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPH
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EETGAAVLGTSEERTASTSTLGEKDPSPAAPSLAKQEAEWTAG
E-ACPAPSS---AQGAMAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRSSDLSDIQEEEEEEE------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEKE-KPGAGCSSQDPGPPEPALLG-LDCDSGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPP--LPAWEKGEPERRGRSATGRA------KEPLSRAT-ETREARG-
QDSSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGS-----------AR-TTGPPPKPRRSKKAESEG--
-P----AQPCPGPPKL----V-PSTELKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TPQ-
-AESQ-DW----GC-TTQ------GPPGA---PGG-PCAPSPD-----------------
-------------SAPRIERGEPQGRSEKVWGFFSKGKQL------------LR------
------RLGSGKKE---------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQLGDR---GA---
----------------------------------------------MEPWALPAWQCWTQ
---GRGCEPEDASPSIADTP-TALQVRGLRSE------ESSK----PEGAHRP--AGNTD
PEGTDTGLPKLGQQAESHG-----------YSCL--QPEDE---------DAQ--A---C
-KAKSNVGFGVRSNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------PPGPTALSR------------V
GAPA--PGAPGE----A----ILQDDVDSPQVALGEP--EKQQRVQQLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENAELKGQL
L--GVKQERDSALRRSQ--GLQSKLESLEQVLKRMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-V-GP-LEHARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCSVLGDHPPPHCCCST---PQPCKV---SPNDIDLDLP
PGSP-GRCTPKSSEPAL---------ATLAGVPRRT-AKKVESLS--NSSR---------
-----------SESVHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGNSGGARIQVFLARYSYNPLEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DLSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRRLVVLKQLAHSVVLA---WELPP---EKVDVRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLQA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRIHRLTATSAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFCHLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQVEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESTDSIPAPVAPALD-PACQSARMSCLS-----PRPSPEVRAPLASVSPGLGDPSFP--
---LRHPAPDGT-------QDSP----ASLPMEMS---KGSQE-EP--PVPCSQE-----
------------------ESGAAVLGTSEEKRAIEPALGWEGPSPVAPSLAKQEVEWTSG
E-VGPTPSS---TQGEPAQK---APSTEACHGGDLGSGLKLRAEKEDVS--ELGVRLVNS
LVDHGRNSDLSDIQEEEEEEE-----EEDEEEDLGSRPCSPQKQVA---SNSIRENGAKP
---Q----PDPLCETDSDEEILEQILELPVQQLCSKKLF-SIPEEEEEEEEEEEEEEEEE
EEGQE-QSEPASSCQDPSQSELALQG-LDCDSSQSQ----GPGLCPLS------------
-PEPSRAR---EHLEDVLGI---AGGN-SRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQTTARPG----PLRERGSLPVIEGIRVGQEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EL
EAGS-GGI-----GITSSCYPTDGEPWGTAAVGRSRGP----------------------
---LKVNSGPNPYLR--LPAWEKGEPERRGRSATGRT------KEPPSRAV-ETGESRG-
PDNFGRRGPQR----RG--ARVPRPATTELAP----TRSPL-EAPAHQNLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDSDGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLPPDVLTEVL--GDGLSVYPSAH-MTGPPPKPRRSKKAELEG--
-P-----QPCPGPPKL----I-HSALLKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------L--ESG-TSQA
ESQVSGER----AYQLSISPTLLVFWNWD--VTGGWGGSLRGQVHNTKEHCMSQQSRVLL
GHPHLVYAPLGRSVMAETLIPRPSDSTDANQGSMQGRDPM------GKDPATSQ------
------SLGCSHPA---------------SSSWLQDNF---------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------P----A--RASSLDFLAKA-SCCSLYS-T-LSCPKA-SESEAPAS-S
TDTFVAGSPNSSPPR------------------SHRKPKDPRGGEGCGNQPPE-GLT--P
SPLGRNYCALVKRNSELSEALQRLARCCSELREDNLQLRRGGGPRE-DEKVKRLKMKHAE
LAGLAQRLEDRARKL-QETNLRALSAPVLG------ENRAGLELC-QALARQRARDLSEQ
ASVLLAKDKQIEELKQECHLLQARVATGLDSPSHPAGGVP----HAQRLNF-SDLDRLQR
ESQREVLPLQRQLTLQQG-KACAR--SEV-------------------------------
------------------------------TSQSPHCEES-RRRVQALERELDAERRNSK
ALSVQAAAAQRHGEEAEAQLQAALCKGACLTEENERRQAQS--HWVRKVAGEKSDVHGQL
G--RACQERDAAGLLAE--QLLQQAA----------LGQNRQQQLQHDLQKALSDLQ--A
ARKELKTLQDQLGHLP-EQPQEATQALVS---------QATGGGRH------KFQSQAED
CAPSQPT---KEQ------------------PPVCPTL------------QEGPVPLGEP
ASSLLV--------------SDRVP--ANQHLDSRCQAKKTSSQS--TSFS---------
---------E-VESMWATVP-SCLTLDVDTASEVDDLEPDSVSPSLEVRD----------
-PEA-PSTSKLKIFQARYSYKPFEGPNEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PESELPLTAGDYVYVFGDLDKDGFYEGELEN
GQQG--LVPSNLL---EQIPDSPYLSNLSPRSLESPNHLG-------------PT--ILP
VGQS--------------KAS-------------KEASLL--L-----------------
----------------------------------GEGQGSVD---RGPG-QVGREGSKTE
K-AIENLEIKK-ESCWLDSSQNIQEQSF------------CIPCLG---TKGLPFVGPTQ
LHLQRVTATSAEIAWVYGSSRHPHVVYLDDQEHALTPSGVSCYTFQGLHPGTQYQAQVEV
E--VGLPWDLEQVSWETVSSTITFNTPLAGPPDPPLDVLVEHH-TLPGFLVVTWIPVTID
SAGSSNGVQVTGYAVYADGLKVAEVTD---ATAGSTLLELSQLQVPLTCQKLSVRTMSLC
GESLDSVPAQIPEDCFIY-DLLPEIPPLSN------------------------TF----
------TFPIYH-------QK---MVLASLNTRVG----------PHSPESCGE------
----PQAKF--------PEVL--------------PEEPLRKHPPL-SNLSSEE------
A------G-------------------------KQAQGPTEVQK----------------
------------------------------------------------------------
-------------------GCRKDLPFQKSPQNHRPLP-PSGQSVIEEN---HYG-H---
-------MNT---SKGSSPCFN-H-LS---------------------------------
---PKCGPRKELCQE---------------------------------------------
--------KAAR------------EKALRQKQ------------------------DAQV
ST-----------------------PSQQGT-SQQ---YAADSY------NIL-------
--EEE--MILAP--------------WYTGTQEQKEKLGPQCR------------Q-GQ-
A-------L-----V---------------------------------------------
-------------------GKK------ECQL----CGPP--QLGPEANTPARI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YNPLAMSANPKAAEKDLAFQKGQFLRAWGSQDPYCFYHAECNGQVGNIPGHLVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2510)

VEVGT
EQPD--RRWHLPAQGHLPSVDHLEDFEGPTR----P-----QVSFLRPQ-----------
-----------------GNSRGP--ALWTPKTMMVALDYDPRDRKAGSR

PF07653 // ENSGT00390000017228_1_Domain_5 (2510, 2612)

AKGKLALRAGD
VVTVFGPVDDKGFYY---------------------------------------------
-------------------GELGGHRGLIPAHLLDDLSVHRE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---GA---
----------------------------------------------MEPWTLPAWQSWTP
---GQGGNPGSSAPGIADTP-AALQVRERRPK------EGSG----PEEAQSPGPVGSTD
PEGT--GLSDPGQQATGSR-----------PSCP--SLEDE---------EVE--P---F
PKAKLNMGFGDRPNLELLRALGELKQRCAILKEENQMLRKSSFPET-EKV---RLKKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVARP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPL---PAR---------PRDPTVPAR------------A
GAPA--PGAPGE----A----TPQEDVDNPPVILGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKEAQTEA---LVEESRLSGRA----EEQVEWENVELRGQL
L--GVTQERDTALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVQRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSAMGCSALGDRAPPPCCCST---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSESGP---------ATLSGVPRRA-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEXXXXXXXXXXXXXXX-XXXXXX-----------
-XXGSRGGARI

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPKPEEE--EDAGDELSLSPP---------PEGLGEPPA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRHLVVLKQLAHSLVLA---WELPP---ERVELRGFHICVN---GELQ-QALGPGVPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2367)

SDPLRCCLAVGARAGLVPSQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPAARPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGWEKLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXX--
---XXXPGPCGS-------EP----GSSSPPREMP---KGTEGELP--VPGCQE------
-----------------EAAGTAVLGAPEERRAGSPAQGESGPGPIVPSLARQEAEWTEG
E-AHLAPHS---TQGVPAQR---APNTEACLRGDTGSGLRPQAEREDTA--ELGVRPANS
LVDHGRNSDLSDIQEEEEE---------EEEEELGVRTCSFQKQVA---GSSIRENGAKS
---Q----PDPSCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDE---------
--EEE-KPRAGCSSQDLGPLEPALLG-LDCDGGHPR----GPGLCPLS------------
-PEPSRAG---DRLEDMPGL---AGGS-SRRRGGGS-----------PEKPLNRRRP--P
DSREHCSRLLSNG-GPQASGR----PGPARERGSLPVVESTKAGLEAGGRGRPGPA----
-------------R-RCPRGRA----PESGL-TRLSLPKCLEIS------IY--SED-EQ
KAVS-GSI-----TITSSCYPGDGGAWGPAPIGRPRGP----------------------
---LRVNSGHNPYPR--LPAWEKGEP-RRGCSASGRA------KESSFRXXXXXXXXXX-
XXXXXXXXXXX----XX--XXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXX

PF07653 // ENSGT00390000017228_1_Domain_3 (2367, 2396)

VFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVDS
PAG----RQQLLQQGYLPPDVLVEGS--GNGLFVYSTAR-TSGPPPKPRRSKKAESEG--
-P----VQPCPGPPKP----I-PSAGLKAP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

HSMVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------PDREPG-TLQA
ESQ---------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------ELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPRPEEE---DAGDQLSLSPA---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WEPPP---EQVELRGFHICVN---GELR-QALGPGAPPK
A-VLENLDLQA-GPL-HVSVQALTSRGT------------SDPLRCCLAVGARAGLVPSR
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPPARPSTYWVTFCHLRPGTPYQARVEA
QLPLQGPWEPGRERPEQRAATLQFTTLPAGPPDAPLDVQIEAG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVAVRTMSPH
GESADSIPAPVTPALA-PACLPAQVSCPS-----PRPSPEARPPLAPASPGPGDPSSP--
---LQHPAPHGT-------QEPPGPPPASPPRETP---KGSQE-EP--PAPCSQ------
-----------------EEAGAAVMGTSEERRAGEPTLGNKGPGPAAPSPAEQQTEWTSG
E-ACPAPCP---TQGAPAQQ---VPSTEAGQGGDPGSGLRPRAERED-I--ELGVRLGNS
LVDHSRNSDLSDIQEEEEEE-------EEEEEELASRTCSSQKQPA---GNSIRENGAKP
---Q----PDPFSETDSDEEILEQILELPVQQFCSKKLF-SIPEEEEE-----------E
VEEEE-KPEAGPSSRDSGPPEPALLG-LGCDSGQSR----GPGQCPLS------------
-PEPSRAG---DRLEDIPGL---VGGS-SRRRVGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNS-GPQASGR----PGPMRERGGLPVIEGTRGGPEAGGRGRSGPS----
-------------R-RCPRGQA----LESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGV-----SITSSCYPGDGEAWGTAPVGRPRGP----------------------
---LKANSGPNPYPR--LPAWEKGEPERRGRSATGRA------KEPLSRVT-ETGEPRG-
QDSSGRRDPRK----RG--TRAPRPGTAEL----VPPRSPP-EALTYQDLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGEKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQHLLQRGYMSPDILLEDS--GNGPFVYATAG-TAGPPPKPRRSKKADLEG--
-P----AQLCPGPLKL----V-PSADLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGLGPESGS------LDRESG-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------MRDVAERRQQLEKDHEDALFALQ--K
RQEEVKRLNEAQVEAK-KEHEEATKLLEA---------KVKSLEEKCRSQTEQFSLLSQE
LERFRLQTGDIGLL---TSTLVTTDL----PPPQCCSTPGVPQVNKGIQQQLGKTFFLYG
GSSMLLE-----------------------------ILKRRTQVD--SAK----------
---------A-PIQIAVNP-SFMSYFKVDTASEMEDLDADSISLH--------------P
EPES-RFPAKLH

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

VYLARYSYNPFDGPNENPEAELPLTAGEYIYIYGDMDDDGFYEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

VSDDDLIAFQPTEIN--ELSQS-------------SGQDISF
LSGSSN-------------ERSED---------GSSLSPL--PCETQATSEGASDILA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1364)

VP
YPRKLAIIKQLARSIVVG---WEPPLVTAGTRNIQSYNIYID---NELR-QNVQCGGQTK
A-LIEKLELKT-RTY-RISVQSVTEDGC------------SDR

ENSGT00390000017228_1_Linker_2_3 (1364, 2333)

MRCTLLVGHGYSLAPTQ
LRVRSLSATCAEITWQPCNSNYSHALYMNDERCGLAKAGTYWYSFSSLRPSTLYNVKVEA
H-PQRIPWELPLERREQKATVIQLTTPSAGPPDAPLDVQVELG-PTPGVLLISWLPVTID
AAGSSNGVRVTGYAVYADGQKVLEVTS---PTAGSVLVGMSHLQLLQVSKEISIRTMSPS
GESVDSVPAKIPSALLNNPDCSSLINPFS-------------NSLTSEPAMDGTHENAPP
ALPQTASIAVSG-------SV---QPLDSASDSVEVSKISLQEKESTFIQKTIPHNDSTL
PPN-SQAKK--------DLRGQ--LRMLA---SEHPEEKSSPLTERST--ASKEDCSSPE
T------EH-------LEEENKRRCNREISIEDFLEEGPEKT---------ANNYTNEGL
NTEHSPSSTLSDIMEEEEGENPEEEDSPKINKKRQIGINWHTKLDC--------------
------------CETDSDEEILERMLALPLQKHCSKKLF-SIPEVTEEEDEEEVYYK---
--------AP---LAKTTMHSN-DLTSEHCG------KDWDLKPNVLISQHQHENTKTPL
FGSSTCNTKRSYCWTDRANSCP----ESNRKRQGD-------------------------
-AREQCSRMVANSSQT----VFFNPRSHNQKE----------QGLHTAAKNTPQDSSQTE
RDGWSDCSSQSEPIRHTKKRRA--LKKQVN--VQD---NSAEITLGHNIQGSRQGSR-ND
DLSSR-------------------------------------------------------
-LG--------------SNTIVH-TSGRDGAGKV-NSNFSSAST-IK-RL----------
HHQARQLGQLSFLPTEAAYCISPEYHQEVIP------HKEQSPLKPQKLETA

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RIFVALFD
YDPVIMSPNPDAYEEEVPFKEGQILQIFGDKDADGFYHGECAGKTGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

LHIQN
EDM----GAELLKRGWVTSPTILNDLE---------------------K-----------
-----------------SRKIHH--DLSVPK

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

KMVAIFDYNPRENSPNMDVEAELNFTAGD
LITVFGPMDEDGFYY---------------------------------------------
-------------------GELNGLRGLVPSNFLESAQPQVE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------VERQLFLKYILEHFRRLPALSGTPDP---QAAHS
SEETSGAA----------KS-SCRLEPL--DGLSAGAR--------ARSRSLDRVPA---
---ACSNSPDSVLP----A--RASSLDSLAPA-RSLSLDS-T-LSRPKA-PES-----SS
PDASIPGSLSPP-----------------PPLSERRRPSDLRGGEESGSQPCE-ALN--P
LPPGPDYSELLKQNLELSEALQVLARRCSGLREENLQLRRAGFSDKADKKVKRLKVKHAE
LTDLARRLEDRAHKL-QETNQRAVSAPVPG------ESRAGLELC-QAFARQRARDLSEQ
ASVLLDKDKQIEELRQECHLLQARIASGLSSAPLAAGGAA----CAQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQAT-SSAR--AEA-------------------------------
------------------------------GGQSAPCEEA-RSQVQALERELSAQRRE-R
ELGAQAAAARRRGEKAEAKLXXXXXXXXXXXXXXARLQAQA--DWMGKVAAENKDVRGQL
G--LACRERNAAGLLAR--QLLQQAA----------RGQDRQQQLLHDQQKALCDLQ--T
AWEEMRALQCQPGHPP-QEPREAPPAPES---------QVRSSGRT------KLQLGPED
QASSQPSRAKQEK---------------------EDFL------------LENPVALGEA
TSAPKV--------------PDRVP--S-----SRPLAKKTSSQS--NSSS---------
---------E-VESMWAPVP-SCPTLDVDTASEVEDLEPYSVSSTLEVGG----------
-SEA-PTTPKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

KIFLARYSYNPFEGPNKHPESELLLTAGDYVYVFGDMDEDGFYKGELED
GRQG--LVQSNLV---EQISDSDILGCLPHEFP----DFG-------------PT--RLL
AGQG--------------KAS-KE---------DTGHSLV--P-----------------
----------------------------------GKAQGTVD---REPHATTVRVGSKTE
V-AIEISDAKM-EDGWLGSQQSMGKRGF------------SRPLLG---TNSVFCVAPTQ
LYLKSVAATSAEITWVG--SSHPHMVYLDDLECALTLAGVSCYTFHHLHPGTRYQVRVE-
---VYPPWDSLPERWETMSSTITFNTPLAGPPDPPLDVLVEH-HASPGLLVVSWLPVTID
SAGSSNGVQVTGYAVYSDGFMVAEVAD---ASPGRIFLEFSXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------XXXXXXX--
----XXXXXXXX-------XX---XXXXSPRAKAS----------PHSPGSCGE------
----PQAKF--------LEAF--------------PEEPPRRQSLK-PRLSSDGEFPSAG
S------D-------------------------SQAQRPTEARE----------------
------------------------------------------------------------
-------------------LSRKDQLFQKSPRNHRPPL-PQGQSRGEED---QYR-H---
-------MGT---SQSPAAGVI-C-RS---------------------------------
---PECGPRKEPCQE---------------------------------------------
--------KAAL------------EKVLRQKQ------------------------NAPA
FT-----------------------PPQLGT-SQR---YVSDFR------DILQE-----
-----EAGRFGL--------------WGREGREQRKELRRQSR------------P-GQ-
ALGGKREGWFQEPSL---------------------------------------------
-------------------ALCPAPSSRVIRM----SRGGDPPLGTRVDPPA

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

KLFVALSD
YIPLVMSATPEAAEEELTFRKGQLLRVWGPQDTHGFYRGEHDGQVGNIPRHLVDK

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

VDTGT
EWTG--GRWHLLGQGYLPSVAHLDDFGGLGG----P-----QGSFPLPQ-----------
-----------------GSPRRP--SLWTPK

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

TMVAALDYDPRDGPAGGLVKGKMSLRVGD
VVTVYGPADDKGFYY---------------------------------------------
-------------------GESGGHRGLVSVHLLDHMSLQG-------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRAELEGERARGRSERRRFATQ
TRQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAEMRQL
QQLLHQERDVVLRQARELQRQLAQELVNRGYCSRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPADP---QATHS
LEEPPLEAQSN-TGG-TPKPA-RRLGSL--ESLNTGVR----------------------
-----VHSPNDLLP----T--RAGSLESLATA-HSCSLDN-T-LNCSQA-SESEVRAP-A
TSASIPDTSSPQPPPQ----------LPS----IHRKPNDLQ-KESSENKPCE-AST--S
SPPGLDYHELVRQNSELAEALQVLVRRCCDLREENLHLRRTGFSEEAGEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLRAMSAPVPG------ESLEGLDLS-QVFTCQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQARIAADLGSSSHPEEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AW--ADA-------------------------------
------------------------------GRPSTPSEIT-RHQVQALERELGLQRRECE
ELSVQAAAAERRYEETEAQLQAALHKGARLSEENARLQALA--NWMKKMADENSNVSRQQ
SHTRQRQELEATSLLAE--QLLQQEG----------YAQDRRQQLQHYKNKALSDLR--T
SGKEMQGLQFQPGHPS-ET-SETTQASES---------QARDSKRP------TFKTKSEE
LVLPLPTRDIQ-P-------------------PACLSQ------------QENPVILEEP
AAAPQV--------------SDRNS--TSQSLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSMSTPLEMRS----------
-LEA-PIIPKLKLFLARSS

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1159)

YNPSEGPSEHCQGKLPLTAGDYVYVLGDMDEDGFYEAELVN
GQRG--LVPSNLV---EPISGSPILNHLF-KSP----DVG-------------PT--ALS
AGHS--------------KVL-------------KKGSLL--L-----------------
----------------------------------GEVQ---E---RGLC-QVGRVDSKTD
M-AAESLKTKT-EACWLGLKSSLEEQSF------------SRPLLE---AKGAFCLAPME
LQLQNVTATSATITWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTCYRVRVG-
---VQLPRDLLQVLWETMSSTLTFDTPLAGPPDPPLDVLVEHH-ASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLQVPLSCQKVSVRTMSLY
GESLDSVPAQIPEDFFSC-CPFLGAPPFNYT--------------------DGNP-----
-------FPVCH-------QK---LVQASLGAKSS----------PRGPGSCGE------
----PQAKF--------LEAF--------------PEEHPRKHLSL-SSLSSDG------
T------N-------------------------SQAQGPTEAWK----------------
------------------------------------------------------------
-------------------GYEKDLSFQKSPQNHKPPL-LFGQSGVEEG---HAP-H---
-------ICI---SGSPAPGFV-H-LS---------------------------------
---SEIGHGKIRCWE---------------------------------------------
--------KPGL------------EKALLQNQ------------------------YAPM
VP-----------------------PHQQGS-SQC---QPADFH------HVF-------
--EEKEALCLDS--------------QGTEKPEQRKNKS-QNG------------Q-RQG
TPGSKRECS---------------------------------------------------
-------------------VLCPAPTNKVIKM----TSGSPDQLETDANSPVRVFLALFD
HSPLVISVNSEA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2395)

AEEELAFQKGQLLRVWGSLDLHGFYHGECNGHLGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2506)

EVEVGT
QQTD--GRWHLPAQGHLLSETQHEDLEGLTN----S-----QGSY-MPQ-----------
-----------------GNSRTP--TLWTPKTMVAALDYDPRDGR

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2612)

AGVQAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTPLPRPGDP---RN---
----------------------------------------------MEPWALPAWQSWTP
---GQGGEPGGASPSMADTP-AALHVGELRPE------ESPE----PEGARSPGAVGGIE
PRRTETGLPSSGPGALGSR-----------PSCQ--RLEDE---------ELE--A---S
PKGKLKMGFGDQPNLELLRAVGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---PPPR---------PPGPAAPAR-GGPPAPGH----
----------FQ----A----TPQEDVENPPLVLGEP--EKQQRVQQLESELSKKRKKCE
SLELEARKKQRRCEELELQLREARNENARLVEENSRLSGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLEVG-SLEA--VRVRELEEQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCNTLGDRPPPPCCCST---PQPCRG---S-GLKDFDLP
PGSP-GHCTPKSSESAP---------ATLAGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADGVSLLPAAL-----------
-PEGSGGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTALPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSSS---GGG--DQSKEE---AAGDELSLSPP---------PEGLGEPPAVP
YPRCLAILKQLAHSVVLA---WEPPP---EHVALRGYHVCVN---GELR-QALGPGAPPT
A-VLDNLDPRA-GPF-RVSVQALTSRGR------------SDPLRCCLVLGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPSARPSTYWATFCHLRPGTLYQVRVEA
QLPPRGSWEPGWERPEQRTATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKVMEVAS---PTAGSVLVELSQLQLLQECREVAVRTMSAH
GESADSIPAPIAPALA-RACLPARVSCPS-----PRPGPEARSPLASASPGPADPSSP--
---LRCPAPHGT-------QDPPGGPPASPSRETP---KGTQE-EP--PAPGSQ------
-----------------EEAGPAVLGASGDGQAGEPTLGERVPGPAASSLVKEEAERTAG
E-ARPAPGG---TQNSLAQR---LPGAEVCRGGDPGSGLRPRVEREDPA--ELGVRLGNS
LVDHGRTSDLSDIQEEEE----------EEEEELGVRTCSFQKQVA---GNKCRENAAKP
---Q----PDPFCEADSDEEILEQILELPLQQFCGKKLF-SIPEEEEEEEE---------
DEEEE-RPGAGCSSRDPGPPEPALLA-LGCDSSRPR----GSGLCPLS------------
-PEPPRAG---DRLEDLPGL---AGGS-NWRKGSGS-----------PEKPANRRRS--P
DPREHCSRLLSNG-GSQASGR----PGPARERGGPPVGEGSRAGPEAGGRGRSAPS----
-------------R-RCPRGRA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
ETGG-GGI-----SSTSSCYLGDGEAWGTAPPGRPRGP----------------------
---QKANSGPNPYPR--LPAWDKGEPERRGRSATGRA------KESPSRAA-ESGESRG-
QDGSGRRGPPW----SG--GRAPRPGSTEL----APLRSPPEEALAYQDLPVRL

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFQEGQILKVFGDKDADGFYRGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDALLEGS--GNGTFVYTTAR-TAGPPPKPRRSKKAESEG--
-L----AQPCAGEPRW----L-PPQ--GAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGDMDDDGFYY---------------------------------------------
-------------------GELNGQQGLVPSNFLEGPGPETGG------SDREPG-TLQA
EGQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLDCSSPAAAVLENQRRELEKLRTELEAERAGWREERRRFA--
--------------LADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQTALEVERQLFLKYILEHFRRNPALSEPANP---QAVHS
LEEPLTQTSSD-SCH-APKPA-CQLRSL--DSLSADVG--------VHSHPPDLVSS---
---ACSSSLDGLLS----P--RASSLDCFAPA-RSHSLDS-T-RSLPKA-SKSEERPS-S
PDTSIPGSQSLPPPPSPLRPPPS--------P--LLKLSNQQGGEGSESQPCK-VLT--P
SLPGLGHQELIKLNWLLAKALRVLARRCSTLQEENQQLRGAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETNLRAVSAPVPG------ESCADLELC-QAFARQRARDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALESELVQWRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGQV
G--RACQERDAAGLMAE--QPLQQAA----------RGQDRQQQLQCDPQKALYDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQARPED
YTVSQPDRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------PETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWVTVP-SCPTLDRDTASEADDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGP

PF07653 // ENSGT00390000017228_1_Domain_1 (1107, 1157)

NDHPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLG-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVLD---RELY-QMVKVGSKTE
V-ATEILYTKM-EACQLGLLQSTGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTLAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLKVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAN---ATAGSTLLEFSQLQVPLTWQKISVRTMSLC
GESLDSVPAQIPEDCFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNTGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECLSSG
A------R-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLFFQKSPQHHRRPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILREKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDL--------------WGTERQEDRREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIKM----PRGGPQQLGTGANTPAGVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFCLSECNRQVGNIPGHPVAEMEVGT
EQTD--RMRHLLAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPRDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVYGPVDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------EAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFRRNPALSEPADP---QAVHS
LEERLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPLDLVSS---
---ACSSSLDELLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PNTSIPGSQSLPPPPSPLWPPPP--------PSVHRKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCAGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGQV
G--RACQERDAAGLMAE--QLLQQAA----------RGQDRQQQLQCDPQKALCDLH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SVA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVN---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYQARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-Q-LH---------------------------------
---TKCGSRKELCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERREPKPQSR------------Q-GQ-
ALGAKRECQLHEPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTPARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVGNIPGHLVAEMEVGT
EQTD--RTWCLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGNP---GA---
----------------------------------------------MEPWALPAWQSWTL
---GQGGEPGDASPSVADTPSAALQVKELRLE------KSSE----PKGGWSSGPMGGID
AEGAEAELPGLGQQAASSG-----------SGCL--RLEDE---------AVE--A---V
PKAKLNMSIRDRPNLELLRALGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPVPRP-------GATLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQER--S-PQSR---------P-----PAR-VG-----A----
--PA--PGAPGE----A----TPQEYVDNPLVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEHEARKKQRRCEELELQLREAQNENARLVEENSRLSGRA--TEKEQVEWENVELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMRDVAQRRQQLELEHEQARLSLR--E
KQEEVQRLQQAQAEAR-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTERFSLLARE
LQAFRLHPGPLDLL---TSALDCGALGDHPPPHCCCST---PQLCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-A-----------
-PEGSRGGARIQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGAQSSGGHSQSRLEEE---DAGDELSLSPT---------PEGLGEPPAVP
YPRRLVVLKQLAHSVVLA---WELPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENVDLQA-GPL-RVSVQALTSRGS------------SDPLRCCLVVGARARLVPSQ
LRVHRLTATSAEITWVPSNSNLAHAIYLNGEECPPACPSTYWATFCHLRPGTPYQARVEA
QLPPRGPWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLHVCREVAVRTMSPH
GESADSIPAPVAPALA-LACLPAQISCPS-----PRPSPEARPPLATASPGPENPSPP--
---PQLSVPRGT-------QDPPGGPPASPPRETP---KRSQE-EP--PAPCAQ------
-----------------EAAGAAVLGASEERRGLEPAQGERAPGPAAPSLAEQEAEWTKG
E-ARPAPCS---TQAVVAQQ---APSLEACQGGDTGSGLRPRAEREDAS--ELNTHPVNS
LVDHSRNSDLSDIQEEEEE----------EEEELGSRTCSFPKQVA---GNSIREDGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCRKKLF-SIPEEEEEE----------E
EEEEE-KPGAGCSSRDPGLPEPVLLG-LGCDSGQPQ----GPGQCPLS------------
-PEPSRAG---DHLEDMPGL---VGGS-GRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNG-GPQASGR----PVPMRERGGLPVVEGTKGGLEAGGRGRPGSS----
-------------R-RCPRGQA----LESGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPADGQSWGTAPVGRSRGP----------------------
---VKVNSGPNPYPC--LPAWEKGEPERRGHSAMGRA------KEPPSRPA-ETGEPRG-
QDSSGRRGPQR----RG--SRAPRPGTTEL----AFPRTPQ-EVLAHQDLPARV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFQEGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PVG----RQQLLQRGYLSPDVLTEGLRSGNGTFVYSTAR-VTGPPPKPRRSKKAEPEG--
-P----AQPCPASPML----I-PSVDLKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TLPA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAAR
ERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVG--------VRSRSLGLVSS---
---ACSSSPDGLLS----T--HASSLDCFAPA-CSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLSPPPSPLPPPP--------PPSAHRKLSNPRGGEGSESQPCE-VLT--P
SPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRAREL-QETNLRAVSAPIPG------ESCAGLELC-QVFARQRARDLSEQ
ASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLMLQQGN-GGA--WPEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RACQERDASGLIAE--QLLQQAA----------RGQDRQQQLQRDPQKALCDLH--P
SWKEIQALQCRPGHPP-EQPWETSQMPES---------QVKGSRRP------KFHARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGES
ASVPQV--------------SETVP--ASQPLS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SSPTLDRDTASEVDDLEPDSVSLALEMGG----------
-SAA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLTAGDYIYIFGDMDEDGFYEGELDD
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PS--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GKAQGMVD---RGLC-QMVRVGSKTE
V-ATEILDTKT-EACQLGLLQSMGKQGL------------SRPLLG---TKGVLRMAPMQ
LHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVE-
---VRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLEVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTVLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDFFMC-HRWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LSLAPPSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPS-VSDQPGEKEN---CYQ-H---
-------MGT---SKSPAPGFI-H-LR---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KAAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NVLKE-----
---EQEALCLDL--------------RGTERREERREPEPHSR------------Q-GQ-
ALGVKRGCQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKM----PRGGPQQLGTGANTPARVFVALSD
YNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGT
EQTD--RRWRSPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2612)

GQGKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPQLGDP---GA---
----------------------------------------------MEPWALPAWQCWTQ
---GQGFKPGDAAPSMAVTR-TPLQVRGLRSE------ESSE----PEGALSPGPVGNTD
PEGTETGLPKLGQQAESPG-----------HSCS--GLEDG---------ETQ--A---C
-KAKPTVGFGVRSNLELLRALGELQHRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSGLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SPGPTALSR------------V
GAPA--PGAPGE----A----ILQDDVDSPQVVLGEP--ERQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENALLVEENSRLSGRA--AEKEQVEWENAELKGQL
R--GVKQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAR-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCGALGDRPPPHCCCST---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------ATPTGVPRRT-AKKVESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PEGPSGGARIQVFLARYSYNPLEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPRELA--DLSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGESLAVP
YPRHLTVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLRA-GPL-HVSVQALTSRGS------------SDPLRCCLAVGAGAGVVPSQ
LRVHRLTATTAEITWVPGNSNLAHAIYLNGEECPPARPSTYWATFGHLRPGTLYQARVEA
QIPSQGPWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQVEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYTIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTTSPH
GESTDSIPAPVAPALA-PACQPARMSCLS-----PRPSPEARTALASVSPGLGDPSFP--
---LRHPAPAGS-------QDSP----ASLPMEMS---KASQE-EP--PAPCSQE-----
------------------ESGAAVQGTSEEKRAIEPTLGREGPGPLAPSLAKQEVEWTSG
E-TGPMPCS---TQGEPAQK---VPSTEACHGGDLGSGLKLRAEKEDMS--ELGVRLVNS
LVDHGRNSDLSDIQEEEEE--------EEEEEELGSRPCSPQKQVA---GNSVRENGAKP
---Q----PDPLCETDSEEEILEQILELPVQRLSRKKLF-SIPEEEEEE--------EEE
EEGQE-KSEPGSSSQDPSQPELALLG-PDGDSSQPQ----GPGPSPLS------------
-PEPSGAR---EHLEDVLGV---AGGN-SRRRGGSS-----------PEKPPSRKRP--Q
DPREHCSRLLGNG-GPQTAARPG----PPRERGGLPVIEGVRVGQEAGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----GITSSCYPTDGESWGTAAVGRSRGP----------------------
---LKVNSGSNPYLR--LPAWEKGEPERRGRCAAGRT------KEPPSRAT-ETGESRG-
KDNSGRRGPQR----RG--ARVPRPGTTELAP----PRSPP-EAPAHQNLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDSDGFYRGQSGGRIGFIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
VAG----RQQLLQRGFLPPDVLTEAS--GNGPSVYSSAH-MTGPPPKPRRSKKAELEG--
-P-----QPCPGPPKL----P-HSAVLKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLESPGPEADG------L--ESG-TSQA
ESQRTRRR----RDQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPPPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGDEPGDTAPSIADTP-TVLHIRELS--------------SQPQEAQSLGPAVGTD
PEGAEARLPSLRQQAGTSG-----------RGSP--RLEDE---------EVQ--A---L
PKATTNTSFGDRPNLELLRTLEELQQHCAILKEENQMLRNSSFPET-EEKVRRLKRKNVE
LSVIAKRLEERARKL-QETNWRVVSAPVPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPL-----R---------SPGPAISAR------------A
GAPA--PVAPGE----A----TPQEDVDSLPVVLGEP--EKQQRVQQLESELSKKRKKCE
NLEQEARKKQRRCEELELQLREAQNENARLVEENSRLTGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLW--E
KQEEVLRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTECFSLLAQE
LQAFRLHPGPLDLL---TSALGGSALGDHPPAPCCCST---PQPSRE---A-GPKDFDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-TEGNLGGPRVQVYLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GQRG--LVPSNFV---ERVSDDDLLTALPLELA--DLSRS-------------SGPELSF
PSGGGGGSSSGGQSSGGHSQPRLEEE---DAGEELSLSPP---------PEGLGEPPAVP
YPRQLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GELH-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGARAGVVPSQ
LRVHQLTATSAEITWVPSNSNVAHAIYLNGEECPPARPTTYWTTFCNLRPGTLYQARVEA
QLPPRGAWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCHEVTVRTMSPH
GESADSMPAPIAPALA-SACSSTRVTCPS-----PRPSPEARTPLAPAPPGPGDPSSP--
---LQRPASHGT-------PGPPGGPPASPTREMP---KGVQE-DP--PPPCSQ------
-----------------EEVEAAVLGVSGERRPSQSTMGERDPGPSAPCWAAQKAEWTAG
E-AGSMVCS---TQGALTQR---VP--EACCGADPG--LRARPEREDTA--ELGVRLVNP
LVDHGRNSDLSDIQEEEEEE------EEEEEEELGSRTRAFQKQVA---GNSVRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEED-------
NGEQE-KPGAGCSSQDPSPLEPVCLG-LGCEGRQPP----GLGRCPLS------------
-PELSRAR---DHLVDMPGL---VGGS-SRRRG-GS-----------PEKPPNRRRP--L
DPREHCSRLFSNG-GPQASAR----PAPSRERSGLPVIEAAKGGPEASGKGRPGTS----
-------------R-RYPHGRA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
EVDS-GGI-----SITSSCYPTDGEPWGTAPAGRPRGP----------------------
---LKVNSGPNPYPH--LPAWEKGEPERRGRSVPGRA------KEPPSRAA-DTGEARG-
QNSSGRKGPQR----RG--AWVPRPSTTEL----APLRSPP-ETLAHWDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGECGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PTG----RQQLFQRGYLSPDVVLEGT--GNSPFVYSTTH-TAGPPPKPRRSKKAELEG--
-P----AQPFAGPPKV----V-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEVGS------PDREPR-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------TE---
--------------------------------------DLALLSPSREKGEQ---GA---
----------------------------------------------MEPQALPTWPGWAP
---NPGGMPGSTAPMWGDAL-VALEAEELDPE------ENLE----PGEAGSPGQMEDTP
SGGEEACRPSL------CH-------PTPSPGSIRRRPQC------------W--EPVDS
LQTWLDSGCGVRPNMELLRALGEMQRRCAILKEENQQLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAHKL-QEANLLMVNAPMPRP-------GASLELTRKTLASQRARDLSET
ASALLAKDKQIAHLQRQCQELQARLSS-------E--GKE----GPQWLNV-WDFDRLLR
ESQQEVLRLQRQIALRNLQEVPLTGSPSS---------LDTTVL----------------
--PPA-PGAPGE----AVPLARPQDDVDILLEGVSLTEPESQQRVKQLELELGKKRKKWE
TLEHEVRKKQRRCEELELQLRKAQSENARLVEENSRLSGRA--SGKEEVESENAELRGQL
Q--GVTEERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLELDHEQARIGLQ--E
KQEEVLRLQQAQAQAK-REHEGAVQLLEX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX---XXXXXX---X-XXXXXXXX
XXXX-XXXXXXXXXXXX---------XXHCGAPRRA-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPE-------------
-TEGVFRGAKL

PF00018 // ENSGT00390000017228_1_Domain_1 (1092, 1159)

QVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLMTSLPPELM--DLSHS-------------SGPELSF
LSGGGAG-SSGGQSSGGGSQARHEEERN-----ELS-------------PSPLLDLPAVP
YPRHLAVLKXXXXXXXXX---XXXXX---XXXXXXXXXXXXX---XXXX-XXXXXXXXXX
X-XXXXXXXXX-XXX-XXXXXXXXXXXX------------XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXIMEVAS---PTAGSVLVDLSQLQLLRVCREVVVRTMSPH
GESVDSIPAQLPPALA-LACPPVQ-----FSSLLPSTNPETKSPPCPASMGPGDSSPL--
---PQHSDHPGS-------QDIAGDPPGSPSKIAE---RLSQEDST--W-DSQQE-----
---ETR-----------SRQAWAA-GGKRDQGTGPPLSGEKEEEAA--------VEKELE
E-SCPAPCP---APGAPAER---MLGVES-GGGDVGPGLCTRAE-RE-DATEVGARLTSS
LMDHGRNSDLSDIQEEEEEEEEEEEEEEEE----EPGTFSP--PAQ--ETNSKESGAKQL
----------DSCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEDEVEEEKEK----
--KEEEKKGPGGSLTYAHLPETQGVG---LNRSGSH--LWELRPSPLT------------
-PDSSGE-----GALRNLPCQPGGSPLGSRRRGGGS-----------PEKLPARKRP--P
DLREHCSRLLGSS-GTQGFGR----SGPSWDRGAPSASEGVKCGTETSGKGWPGLS----
-------------R-RCPRGPV----PDSGL-ASCFAPKCLEIS------IEYDSED-EL
ESVDSGSS-----I---SCCPRDREGQGTGPEGAPLGGRR--------------------
GP-PGAGPAPSHCLR--LSGCEKEELEKKGRSLNCRV------KEPSPRTP-EARELRG-
QDAAGQRGPPR----RG--SRSPRLGAAELVF----PRNQA-KEISPPNEPV

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RIFVALFD
YDPVSMSPNPDAVEEELPFREGQLLKVCGEKDADGFYRGECGGRVGYVPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2491)

VAVGS
PVV----KRQLLQRGYVHPDSPNEGL--GNGSFPLLAPH-PAGPPPKPRRSKKGSCSQPD
----------------------ARVSPSTP

PF00018 // ENSGT00390000017228_1_Domain_5 (2491, 2617)

RSMVAAFDYNPRENSPNVDVEAELSFKAGN
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGIVSGTGGLS---HLEKDSG-VLTA
ESQVCCCPGSTGPLPCPHSL--------------------RPGSTLQV------------
------------------KLGESLAPAKKMRGLISKGKHLLRKLGSGKKE----------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPGSPGPAAAVLEEQRRELEKLRAELEGERARGRSERRRFATQ
TRQLREAAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAELRQL
QQLLHQERDVVLRQARELQRQLAQELVNRGYCSRSGAS---------EAS-AAQCRCRLQ
EVLALLRWETDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPADP---QTTHS
LEEPPLEAQSN-TDG-TPKPA-RRLGSL--ESLNTGVR----------------------
-----VHSPNDLLP----T--RASSLESLATA-HSCSLDN-T-LNCPET-SESEVRAP-S
TTASIPDTSSPQPPPQ----------LPS----KHRKPNDLQ-KESSENKPCE-DST--S
SSPGLDYHELVRQNSELAEALQVLVRRCCDLREENLQLRRTGFSEEAGEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLRAMSAPMPG------ESLEGLDLG-QVFTCQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQARIAADLGSSSHPEEGAT----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AW--ADT-------------------------------
------------------------------GSPSAPSEIA-RHQVQALERELGLQRRECE
ELSVQAAAAERRYEETEAQLQAALHKGARLSEENARLQALA--NWMKKMADENSNVSRQQ
SHARQRQELEATGLLAE--QLLQQEG----------YAQDRRQQLQQYQNKTPSDLR--I
SGKEMQGLQFQPGHPS-ES-SETTQASES---------QVRDSRRL------KFKTKSEE
YILPLPTRDIQ-P-------------------PACLSQ------------QENPVALGEP
AAASQV--------------SDRNP--SSQSLDSKLQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSMSTPLEMRS----------
-LEA-PIVPKLKIFLARYSHNPFEGPSE

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

RSHDELPLTAGDYVYVFGDVDEDGFYEGELVN
GQRG--LVPSNLV---EPISGSPILSHLFLKSP----GAG-------------PT--SLP
AEHS--------------KAL-------------KKGSLL--L-----------------
----------------------------------GEVQ---E---RGLC-QAGRVDSKTD
V-ASESLKTKT-EACWLGLKSSMEEQSF------------SRPLLE---AKGALCLAPME
LQLQNVTATSATITWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTRYQVRVG-
---VQLPRDLLQVLWETMSSTVTFDTPLAGPPDPPLDVLVEHHAASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAN---ATAGNTLLELSQLQLPLGCQKVSVRTMSLY
GESLDSVPAQIPEDCFSC-YPFLEAPPFNYT--------------------DGDP-----
-------FPVCH-------QK---LAQASLSAKSS----------PHVPGSCGE------
----PQAKF--------LEAF--------------SEEQPRKHLSL-SSLSSDG------
A------N-------------------------KQVQGPTEAWK----------------
------------------------------------------------------------
-------------------GYEKDLSFQRSPQNHKPPL-LFGQSGVEEG---HAP-H---
-------ICI---SGSPSPGFI-H-LS---------------------------------
---SEVGPGKILCWE---------------------------------------------
--------EPGL------------EKALLQNQ------------------------YAQM
VP-----------------------HHQQGS-SQC---HTADFH------HIF-------
--EEKEALCLDS--------------RCTEKPEQRK-KS-QNG------------Q-RQG
TPGSKRECQFHEPTS---------------------------------------------
-------------------VLCPAPTSKIIKI----ASGGSDQLETDGNSPVRVFLALFD
HSPLA

PF07653 // ENSGT00390000017228_1_Domain_3 (2346, 2395)

RSVNSEATEEELSFQKGQLLRVWGSRDHHGFYHGECNGQVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2499)

EVEVGT
QQTD--GRWLLPPQGHLHSEAQREDLEGLTN----S-----QGSY-MLQ-----------
-----------------GNSRTP--TLWTPKTMVAALD

PF07653 // ENSGT00390000017228_1_Domain_5 (2499, 2612)

YDPRDGRAGVRAKGKLVLRAGD
VVTVYGPVDDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRPGDP---AA---
----------------------------------------------MEPWALPTWQSWTP
---GRGGEPGDAAPSVADTPPAALQLRELRAE------ESSE----PKGAGSSGPIRGTD
PEEAEACLPSLGQQASSSG-----------PACQ--RPEDE---------EVE--A---F
PKAKLNMGFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPLPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQRETPPR-PPSR---------PPGPALPAR-AEAPA-------
------PGAPGE----A----TPQEDADNLPVILGEP--EKEQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLREAQNENARLVEENSRLSGRV--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLR--E
KQEEVRRLQQAQAEAK-KEHEGAVQLLEVG-RL---EARVRELEEQCRSQTEQFSLLAQE
LQAFRLHPGPLDLL---TSALDCGALGDRPPPPCCCSA---PQPCRG---S-GPKDLDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSH---------
-----------SESIHNSS-KSCPTPEVDTASEVEELEADSVSLLPA-T-----------
-PEGSRGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLTSLPPELA--DLSHS-------------SGPELSF
LSVGGGGSSSGGQSSGGRGQPRPEEE---DAGDQLSVSPS---------PEGLGEPPAVP
YPRCLVVLKQLAHSVVLA---WEPPP---ERVELHGFHICVN---GELR-QALGPGAPPK
A-VLENLDLRA-GPL-HISVQALTSRGS------------SDPLRCCLAVGARAGVVPSQ
LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA
QLPPQGSWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCREVVVRTMSPD
GESADSIPAPITPALA-PASLPARVSCPS-----PRPSPEARAPLASASPGPGDPSSP--
---LQHPAPLGT-------QEPPGAPPASPSREMP---KGSHE-DP--PAPCSQ------
-----------------EEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLGKQEAEWTAG
E-ACPAPSS---AQGALAQQ---APNTEACQGGDPGSGLRPRAEKEDAA--ELGVHLVNS
LVDHGRNSDLSDIQEEEEE--------EEEEEELGSRTCSFQKQVA---GNSIRENGAKS
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEE---------E
DEEEE-KPGAGCSSQDPGPSEPALLG-LGCASGQPR----RPGQCPLS------------
-PEPSRAG---DCLEDMPGL---VGGS-SRRRGGGS-----------PEKPPSRRRP--P
DPREHCSRLLSNN-GPQASGR----PGPTRERGGLPVIEGPRTGLEASGRGRLGPS----
-------------R-RCSRGRA----LEPGL-ASCLSPKCLEIS------IEYDSED-EQ
EAGS-GGI-----SITSSCYPGDGEAWGTATVGRPRGP----------------------
---PKANSGPKPYPH--LPAWEKGEPERRGRSATGKA------KEPLSRAT-ETREARG-
QDNSGRRGPQK----RG--ARVPRPSTAEL----VPVRSPS-EALAYQHLPVRI

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGYLSPDILLEGSGMTLK-----------GSPES--------PDS--
-S----PPPPAGPPKL----V-PSAELKAPRS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPQESSPNMDVEAELPFRAGD
VITVFGGMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------LDREPR-TSQ-
-AESQ-VS----EE-LGSQLGRAVCPTGGVVGPGQ-CCSRGAAGVVMQVS----------
-------TVSSAELLSDHQRGAPPGSCP--------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKLGCSSPAATVLENQRRELEKLRAELEAERAGWRAERRRFAAQ
ARQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AGQCRCRLQ
EVLGQLRWQTDGEQAARIRYLQAALEVERQLFLKYILEHFRRNPSLSEPADP---QAVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSADVG--------VHSRPPDLVSS---
---ACSSSLDGLLS----T--RASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERSS-S
PYTSIPGSQSLPPPPSPLRPPPS--------PL--LKLSNPQGGEGSESQPCK-VLT--P
SPPGLGHQELIKLNWLLAKALRVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-EETNLRAVSAPVPG------ESCAGLELC-QAFARQRAQDLSEQ
ASALLAKDKQIEELRQECHLLQARVASGPCSDPHTGRGGP----CTQWLNV-RDLDLLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSTTCEEV-RRQMLALESELDQRRRECE
ELGAQAAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKA--ENSEVRG--
----PCQERDAAGLMAE--QLLQQAA----------RGQDRQQQLQCDPQKALCDVH--A
SQKEIQALQCQPVHPP-EQPWETSQMPES---------QVKGSRRP------KFQALPED
YTVSQPNRDIHEK--------------------REVSL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPVS-----KKTSSQS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLEPDSVSLALEVGG----------
-SAA-PAAPKLKIFMAQYNYDPFEGPNDH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1157)

PEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNLV---EQIPDSYISGCLPAKSP----DLR-------------PH--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLY-QMVRVGSKTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRSLLG---TKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGMHYRARVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVTD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HQWPETPPFSYT--------------------CGDPSTY--
----RVTFPVCP-------QK---LALAPLNAKAS----------PHNPGSCGE------
----PQDKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGEYLSSG
T------G-------------------------SQAEELAEAWK----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQHHRPPL-LSDQPGEKEN---CYQ-H---
-------MGT---SKSPASGFI-Q-LH---------------------------------
---TKCGSRKEPCQE---------------------------------------------
--------KAAL------------ERILRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---EQEALCLDP--------------WGTERQEERREPKPQSR------------Q-GQ-
ALGAKRECQLHKPSS---------------------------------------------
-------------------APCPAPSAKVIEM----PRGGPQQLGTGANTSARVFVALSD
YSPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHGFYLSERNRQVSNIPGHLVAEMEVGT
EQTD--RTRHLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRP--PLWTPKTMIAALDYDPMDGQTGG

PF07653 // ENSGT00390000017228_1_Domain_5 (2509, 2612)

QAKGRLALRAGD
VVMVFGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTSLPSLGDP---GN---
----------------------------------------------MERWALPAWQSWTP
---GRGGDAGGASPSMAGTP-TDLRVGELRPE------ESSE----PEGARSPGPVGGME
PGRTGTGLPSPARGALSSG-----------PGCQ--RLEDP---------EAE--A---F
SKGKLKMGFGDRPNLELLRAMGELQQRCAILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERARKL-QETNLRVVSAPMPSP-------GASLELCRKTLARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------A--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQREPP---SPPR---------PPGPSVPAR------------A
GAPA--PGAPGE----A----TPQEDVENPAVVLGEP--EKQQRVQQLESELSKKRKKCE
SLEQEARKKQRRCEELELQLKAAQNENARLVEENSRLSGRA--TEKEKVEWENAELRGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVTQRRQQLEVEHEQARLSLQ--E
KREEVRRLQQAQAEAQ-REHEGAVQLLEST--LDSMQVRVRELEEQCRSQTERFSLLARE
LQAFRLHPGPLDLL---TSALGCGAPGDSPPHPCCCST---PQPCRG---S-GPKDLDLP
PASP-GRCTPKSSETAS---------ATLAGVSRRTPAKRAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEADSVSLLPA-V-----------
-AEGGRGGARVQVFLARYSYNPFEG

PF07653 // ENSGT00390000017228_1_Domain_1 (1106, 1157)

PNENPEAELPLTAGEYIYIYGSMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLASLPPELA--DLSHS-------------SGPELSF
LSGGGGGSSSGGQSSGGRSQPRPEDE---AAGEVPSPSPP---------PEGLGEPPAVP
YPRRLAVLKQLAHSVVLA---WEPPP---ERVELCGYHVCVN---GELR-QALGSGAPPT
A-VLENLDLQA-GPL-RVSVQALTSRGG------------SDPLRCCLLLGARARVAPSQ
LRVHRLTATSAEIAWVPSNSSLAHAVYLNGEECLPARPSTYWATFCHLRPGTLYQARVEA
QLPPRGSWEPGGERPEPRAATLQFTTLPAGPPDAPLDVQVEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAVYADGQKVQPGGA---HLYP---GSRAWVSAF--SHTLGVGTRHPR
MQLSAQCQQP-----V-GASLQPPFPLLC-----PYPPPQI---MXPASPGLGDPSSH--
---LRYPNPRGA-------QEPPGAPPASPPREMA---GGSSE-EP--PAPVSQ------
-----------------EQAGAAVLGASGDGKASEPVLGECVPGPATSSVAKEDTEQTAG
E-ACLAPGT---TQGALAQR---LPCAQACRGGDPGAGAGKRGPWGKDRAVTFALKGGQG
FQVTQSP--APQPQS--PPSK------KQDQRESGPESHSVS---------RAGPRGALR
SPPKNWVRRGAECREQARPEMMGGL-----------------------------------
----------------PAPPRKLPAP-RGSQRAL--------------------------
----------------HQAG---LSGR-SYRTGRLGPPFLFRRVEAGPELLPSCRPAEGP
GRTPRCLTDPSCGPG-----PQGSSP-----DGPPA----QLHPPARG-QTWEDSGE---
---------VSKGT-WGPSNRVSPSQDEWGV-P---LQKERGAC------PQIGAQD-EQ
ETGG-GDM-----SIANSGCLGDGEACGAAPVGRPRAP----------------------
---PKAGSGPHPYPY--SPAWEKGETERRGRSATGRA------KEPPPRAA-ESGEPRG-
LESPGQSGSQR----RR--GWAPRPGSTEL----APPRSPPEASLALRDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRWGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----TQQLLQRGHLSPEVLAEGS--GNGLFVYSAAH-TAGPPPKPRRSKKAEWEGP-
------AQPCAGPPAL----A-SSAGLKAPHS

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRESSPNVDVEAELPFRAGD
VITVFGAMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGG------SDREPG-AAPS
EGQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MTKDSPTPLGGGRASPKKPSSPGPAAAVLEEQRRELEKLRTELEGERARGRSERRRFATQ
TRQLRESAEQERQQLADHLRSKWEARRLRELRQLQEEVQREREAEIRQLLRWKEAEMRQL
QQLLHQERDVVLRQARELQRQLAQELVNRGYCSRSGAS---------EAS-AAQCRCRLQ
EVLALLRWDTDGEQAARIRHLQAALDVERQLFLKYILEHFRWQPALPGPADP---QTTHS
LEEPPLEAQSN-TGG-TPKPA-RRLGSL--ESLNTGVR----------------------
-----VHSPNDLLP----T--RASSLESLATA-HSCSLDN-T-LNCPQA-SESEVRAP-A
TSASIPDTSSPQPPPQ----------LPS----IHRKPNDLQ-KESSENKPCE-AST--S
SPPSLDHHELVRQNSELAEALQVLVRRCCDLREENLHLRRTVFSEEAGEKVKWLKVKHAE
LTDLAQRLEDRARKL-QETNLRAMSAPVPG------ESLEGLDLG-QVFTCQRAQDLSEQ
AGALQAKDLQIEALRRECHLLQARIAADLGSSTHPEEGAM----CAQWCNI-SDLDRLQR
ESQREVLRLQRQLTLHQSKAG-AW--ADA-------------------------------
------------------------------GRPSTPSEIT-RHQVQALERELGLQRRECE
ELSIQAAAAERRYEETEAQLQAALHKGARLSEENARLQALA--NWMKKMADENCNVSRQQ
SHTRQRQELEASSLLAE--QLLQQEG----------YAQDRRQQLQHYKNKALSDLR--T
SGKEMQGLQFQPGHPS-ET-SETTQASES---------QARDSRRP------TFKTKSEE
HVIPLPTRDIQ-P-------------------PACLSQ------------QENPVTLEEP
AAAPQV--------------SDRSP--ASQSLDSKPQAKKTSSQS--NSSS---------
---------E-VESMWATVP-SCLSLDMDTASEVDDLEPDSMSTPLEMRS----------
-LEA-PIIPKLKIFLARYSYNPFEGPSEH

PF07653 // ENSGT00390000017228_1_Domain_1 (1110, 1159)

CQGELPLTAGDYVYVFGDMDEDGFYEGELVN
GQRG--LVPSNLV---EPISGSPGLNHLSLKSP----DVG-------------PA--ALP
AGHS--------------KAL-------------KKGSLL--L-----------------
----------------------------------GEVQ---E---RGLC-QVGRVDSKTD
M-AAESLKTKT-EACWLGLKSSLEEQSF------------SRPLLE---AKGAFCLAPME
LQLQNVTATSATIIWASGSNRYPHVVYLDDEEHILTPSGVNHYTFQGLHPGTCYRVRVG-
---VQLPRDLLQVLWETMSSTLTFDTPLAGPPDPPLDVLVEHH-VSPGILVVSWLPVTID
SAGSSNGVQVTGYAVYVDGFKVTEVAD---ATAGNTLLEFSQLQVPLSCQKVSVRTMSLY
GESLDSVPAQIPEDFFSC-CPFLEAPTFNYT--------------------DGNP-----
-------FPVCH-------QK---LVQASLGAKSS----------PRAPGSCGE------
----SQAKF--------LEAF--------------PEEHPRKHLPL-SSLSSDG------
P------N-------------------------SQAQGPTEAWK----------------
------------------------------------------------------------
-------------------GYEKDLSFQKSPQNHKPPL-LFGQSGVEEG---HAP-H---
-------ICI---SGNPAPGFV-H-LS---------------------------------
---SEIGPGKICCWE---------------------------------------------
--------KPGL------------EKALLQNQ------------------------YAQT
LP-----------------------PHQQGS-SQC---QPADFH------HVF-------
--EEKEALCLDS--------------RCTEKPEQRKNKS-QNG------------Q-RQG
TPGSKRECS---------------------------------------------------
-------------------VLCPAPTNKVIKM----TSGSPDQLETDANSPVRVFLALFD
HSPLVISVNSEA

PF07653 // ENSGT00390000017228_1_Domain_3 (2353, 2395)

AEEELAFQKGQLLRVWGSLDLHGFYHGECNGQVGKIPGHLVV

ENSGT00390000017228_1_Linker_3_5 (2395, 2498)

EVEVGT
QQTD--GRWHLPAQGHLHSEAQRENLEGLTN----S-----QGSY-TPQ-----------
-----------------GNSRTP--TLWTPKTMVAAL

PF07653 // ENSGT00390000017228_1_Domain_5 (2498, 2612)

DYDPRDGRAGVRAKGKLVLRAGD
VVTVFGPVNDKGFYY---------------------------------------------
-------------------GEYGGHRGLVPAHLLDDLPVHGE------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTLPRLGDL---GA---
----------------------------------------------MEPWALPAWQHWTQ
---GQGCKPGDASPSIAGTP-TALQVKGLRSE------ESSK----PEEAHSPGPVGNTD
PEATETGLPKLGQQAESPG-----------YSCY--RLEEE---------EAQ--A---Y
-KAKFNIGFGDRPNLELLRALGELQQRCTILKEENQMLRKSSFPET-EEKVRRLKRKNAE
LAVIAKRLEERAQKL-QETNMRVVSAPVPRP-------GSSLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLSL-------V--GKE----GPQWLHM-RDFDRLLR
ESQREVLRLQRQIALRNQREPL---RPAR---------SPGPTAPSR------------V
GAPA--PGAPGE----A----VLQDDVESPQVVLREP--EKQQRVQHLESELCKKRKKCE
SLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGRA--TEKEQVEWENSELKGQL
L--GVTQERDSALLKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEGQCRSQTERFSLLAQE
LQAFRLHPGPLDLL---TSALGCNALGDHPPPHCCCSI---PQPCQG---S-GPKDLDLP
PGSP-GRCTPKSSEPAL---------TTLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-PESHSGGARIQVFLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYIYGNMDEDGFFEGELMD
GRRG--LVPSNFV---ERVSDDDLLSTLPRELA--DSSHS-------------SGPELSF
LSGGGGGCSSGGQSSGGRSQPRPEEE---AAGDELSLSPP---------PEGLGEPLAVP
YPRHITVLKQLAHSVVLA---WELPP---ERVDLRGFHIFVN---GELR-QALGPGVPPK
A-VLENMDLRT-GPL-HVSVQALTGKGS------------SDPLRCCLAVGAGAGVVPSQ
LRIHRLTATSAEIAWVPGNSNLAHAIYLNGEECPPARPSTYWATFCNLRPGTLYQARVEA
QIPSQGSWEPGWERPEQRAATLQFTTLPAGLPDAPLDVQAEPG-PSPGILMISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVEVSQLQLLQACHEVTVRTMSPH
GESSDSIPAPVAPALA-SACQPAGMSCLS-----PRPSPEVRTPLASVSPGLGDSSFP--
---LRHPVPHGT-------QDFP----ASLSIEMA---KGPRE-EL--PAPCSQE-----
------------------EAGAAVRSISGEKRAIEPTLGQEGPDPVAPSLAKQEVECTSG
D-AGPIPCS---SQGELTQK---EPSIEACHGGDLDSGLKLRSEKEDMS--ELGVRLVNS
LVDHSRNSDLSDIQEEEEEE-------EEEEEELGSRPCSSQKQVA---GNSIRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQRLCSKKLF-SIPEEEEEE---------EE
EEGLE-KPGPSCSSQDPSQPELALLG-PGCDSSQPQ----GPGLCPLS------------
-PELSGVR---EHLEDVLGV---VGGN-NRRRGGGS-----------PEKLPNRKRP--Q
DPREHCSRLLGNG-GPQTSARPV----PPRERGSLPVIEGTRVGQEPGGRGRPGLS----
-------------R-RCPRGPA----PESSL-VSCLSPKCLEIS------IEYDSED-EQ
EAGS-AGV-----SINSSCYPTDGEAWGTAAVGRPRGP----------------------
---PKVNPGPNAYLR--LPAWEKGEPERRGRSAIGRT------KEPPSRAT-ETGESRG-
QDNSGRRGPQR----RG--ARVPRSGTTELAP----PRIPQ-EAPPHQDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQLLKVFGDKDADGFYRGESGGRTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PAG----RQQLLQRGFLPPNVLTEAS--GNGPSVYSSAHNTPGPPPKPRRSKKVELEG--
-P----TQLCPGPPKL----I-HSAAQKTSRP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGNMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEAGS------L--ESG-TSQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
-------------------------------------MQREREAEIRQLLRWKEAEQRQL
QQLLHRERDGVMRQARELQRQLAEELVNRGHCSRPGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPVSSGSPDP---QAVHS
LEELLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVG--------VRSGSLDLVSS---
---ECSSSLDSLLS----T--HASSLDCFAPA-RSRSLDS-T-RSLPKA-SKSEERPS-S
PDTSTPGSRRLPPPPSPLPPPP--------PPSVHRKLSNPRGEEGSESRPCE-VLT--P
SPPGLGHQELIKLNWLLAKALWVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAE
LTGLARRLADRARKL-QETSLWAVSAPVPS------ESCAGLELC-QVFARQRVRDLSEQ
ASALLAKDKQIEELRQECHLLQARLASGPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PEA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELGAQAAAARRRGEEAETQLQAALLKNAWLTEENGRLQAKT--DWVRKVEAENSEVRGHL
G--RVCQERDAAGLIAE--QLLQQAA----------CGQDRQQQLQRDPQKALCDLH--A
SRKEIQALQCRPGHPP-EEPWETSQMPES---------QVKGSRRP------KFQARPED
YAVSQPNRDIQEK--------------------REASL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPLS-----RKTSSRS--NSS----------
---------S-EGSMWATVP-SCPTLDTDTASEVDELEPDSVSLALEMGG----------
-SAA-PAAPKLKIFMAQYN

PF07653 // ENSGT00390000017228_1_Domain_1 (1100, 1157)

YNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELED
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PN--QLP
AGQD--------------EAL-EE---------D---SLL--P-----------------
----------------------------------GEAQGVVD---RGLC-QMVRVGSRTE
V-ATEILDTKM-EACQLGLLQSMGKQGL------------SRPLLG---SKGVLRMAPMQ
LHLQNVTATSAKITWVYSSHCHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRAWVE-
---VRLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVEH-HASPGVLVVSWLPVTID
SAGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVPLTWQKVSVRTMSLC
GESLDSVPAQIPEDCFMC-HRWPETPPFSYT--------------------CGDPSTY--
----GVTFPVCP-------QK---LALAPLSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRQSPV-SNLGSEGECLSSG
A------G-------------------------SQGQELVEGWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPPL-VS-DPGEKEN---CYG-H---
-------MGS----KSPAAGFI-C-LH---------------------------------
---TECGPRKEPCQE---------------------------------------------
--------KAAL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGA-SQQ---YASDFH------NILEE-----
---KQEALCLDL--------------WGTERREERREPKPHSS------------Q-GQ-
ALGVKRECQLHEPSS---------------------------------------------
-------------------ALCPAPSAKVIKT----PRGGPQQLGTGANTPARVFVALSD
YNPLVMSANPKAAEEELVFQKRQLLRVWGSQDTHDFYLSKCNRQVGNIPGHLVAEMEVGT
EQTD--RRRHLPAQGHLPSVAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSERL--PLWTPKIMIAALDYDPGDGQMG

PF07653 // ENSGT00390000017228_1_Domain_5 (2508, 2611)

GHAKGRLALRAGD
VVMVYGPRDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHMSLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------AV
LQSGADYSFLVSQNTKLLSALEDLQHRYSSLMEENSLLRRSCFPET-EEKVKHLKRKNAE
LAVIAKRLEERARKL-QEANLKVVTAPVPLK-------GSSLELCKKAFACQRAKDLTEQ
ASALLAKDKQIEALQQECRELQAKL-I-------A--GKD----DPCCLNV-VEFDRLLR
ESQKEVLRLQRQIALKNFKECLRSSK--T---------SSGSSLEAR-SGDPVVEPGV-L
PLGIA-SEGHEN----F----PPRNAITDP---------ESSQQIQQLEFELKKKRKKCE
NLEHEVRKKHKRCKELEIQLQEIQSENARLAEENLQLNEKA--GWAGQVESENADLKLQV
V--LVTKERDSVIQTNQ--GLQTKLENLEQVLKHMRDVAERRQQLEAEHKEALLVLQ--E
KQEEVRRLQQAQAEAK-REHEGAVQLLES--TLDCMQARVKDLEEQCRNQTEQFSLLSQE
LKQFRLQTGKIDLL---TSTLVTSEL----PLALCSSS---PQLHWE---K-GNCWRCLA
CGCF-DKCVPDAAVGSP---------VS--ATGSQKQAKKVESQS--SSSK---------
-----------SESMQNSP-KSCPTPEVDTASEMEELDVDSISLMPE-------------
--TGSQGPAKLQ

PF07653 // ENSGT00390000017228_1_Domain_1 (1093, 1159)

VFLARYSYNPFDGPNENPEAELPLTAGEYIYIYGDMDEDGFFEGELMD
GRRG--LVPSNFV---ER

ENSGT00390000017228_1_Linker_1_2 (1159, 1259)

ISDDDLMTFLPSELN--DLTHS-------------SYQEKSF
VSASTS--------SGDKSDFSIE---------ESSISPLA--SRAEGDQEEAVSHTA

PF00041 // ENSGT00390000017228_1_Domain_2 (1259, 1361)

VP
YPRKLTLIKQLARSIVVG---WEPPLLPTGCPDIQSYNIYVD---EELR-QNVKSGFQTK
T-VIEKLDLKT-KAY-RVSVQSVTEQGS------------

ENSGT00390000017228_1_Linker_2_3 (1361, 2333)

SDKLRCTFFVGQDFCLAPTM
LKVRSVTATSAEVTWLPCNSNYNHAVYLNGEECDITKPGVYWYAFRNLQPSTQYVAKLEA
R-PLKTPWEEVPEGQEQNSAVIHFTTPLAGTPDAPLDVQVEAG-PSPGILVISWLPVTID
AEGSSNGVRVTGYAVYADGQKAIEVTS---PTAGSILVDLSQLQMFQVCREVSVRTMSLY
GESVDSVPAQISSVLQ-EGALPSDVACLS----SHSCQ-QKEAGYGGAQEGPADDAVI--
---LVMPFFLFVSQMEQSVTKAPE--LETPSNSS--------------------------
-----LKIHMETCCTCSVEEPL--KSPSTERERETKEKH-LTPEPVPA-PGQA--DRTEG
T--SR-----DATAGGSSCQE--FLRLSPGKEVMKEMSRVKREQEE--KLSEIGRRQLTL
FAEHNRSSDLSDILEEEEEDEL------------SSEALEEKKWDS--REPFYRENGEKM
E-------TMDLCDTDSDEEILEKILELPLQKNHSKKLF-SIPEVTEDEDEDEDEKGV--
-------MEAGRTEKPLSIQEPFLKA-DGSDSSPDLSAETPWDECTVK------------
----ESRG---DADHESPGFE-PLGWSQSKKKGNNYR----EKIWS----QPEMGRKRQN
DLSEHCSRLLGNCSQM--GSRLYRAPSL-REELNIVSSAGGKEGFDVYNRARQGTSR---
---------RNHTN-AVVSG---FGEPALAA-ALCSSPRSLEID------VEYDSED-DQ
DSTCASPPESRLWPTGDVGRAGHGVGWVSKPPPAI----------------LLPGEGGTE
AS-GNKDPRGQELSG--SAAWQA--PSRRGNRSVRRS------QMQKPLLS-SPG-----
-----------------------------------PPRSAA-SATAVKDDGI

PF00018 // ENSGT00390000017228_1_Domain_3 (2333, 2396)

RIFVALFD
YDPVSMSPNPDAAEEELPFKEGQILKVCGDKDADGFYRGECAGREGYIPCNMVSE

ENSGT00390000017228_1_Linker_3_5 (2396, 2492)

IQVEN
NEI----KRQLLKQGFLPADTPMESI--GNGTFSPPPRR-QTVPPPKPRRSKKGKSSFRA
LP-------------PGQKHQDFEAELLTPR

PF07653 // ENSGT00390000017228_1_Domain_5 (2492, 2617)

SMMAVFDYNPKESSPNADAEAELTFSAGD
IITVFGSMDDDGFYY---------------------------------------------
-------------------GELNQQRGLVPSNFLEAVTSDGGMVEELHSKDKD-AFPPSS
ESQRMRKR----RVQ---------------------------------------------
------------------------------------------------------------
-----------------------------------------------

MAKDSPSPLGA---SPKKPGS-SPAAAVLEIQRRELEKLRAELEAERAGWRAERRRFAAQ
ERQLREEAERERRQLADHLRSKWEAQRGRELRQLQEEMQREREAEIRQLLRLKEAEQRQL
QQLLHRERDGVVRQARELQRQLAEELVNRGHCSRSGAS---------EVS-AAQCRCRLQ
EVLAQLRWQTDGEQAARIRYLQVALEVERQLFLKYILAHFRGHPALSGSPDP---QVVHS
LEEPLPQTSSG-SCH-APKPA-CQLGSL--DSLSAEVS--------VRSRSLDLVSS---
---ACSNSLDGLLS----T--HASSLDCFAPA-RSRSLDS-T-RSIPKA-SKSEERPS-S
PDTSTPSSRRLPPPPSPLPPPP--------PPSIHRKLSNPRGGEGSESQLCE-VLT--P
SPPGLGHQEPIKLNWLLAKALWVLARRCSTLQEENKQLRRAGCPYQADEKVKRLKVKRAV
LTGLARRLADRARKL-QETNLRAVSAPVPG------ESCAGLELC-QVFARQRARDLSEQ
ARALLAKDKQIEELRQECHLLQARVASDPCSDLHTGRGGP----CTQWLNV-RDLDRLQR
ESQREVLRLQRQLTLQQGN-GGAR--PQA-------------------------------
------------------------------GGQSATCEEV-RRQMLALERELDQRRRECQ
ELRAQSAAARRRGEEAETQLQAALLKNAWLAEENGRLQAKT--DWVRKVEAENSEVCGHL
G--RACQERDAAGMIAE--QLLQQAA----------RGQDRQQQLQRDPQNALCDLR--A
SRKEIQALQCRPGHPP-EQPLETSQMPES---------QVKGSRRP------KFQAWPED
YAVSQPNRDIQEK--------------------MEASL------------EESPVALGEP
ASVPQV--------------SETVP--ASQPLS-----KKTSSGS--NSS----------
---------S-EGSMWATVP-SCPTLDRDTASEVDDLDPDSMSLALEMGG----------
-LVA-PAAPKLKIFMAQYNYNPFEGPND

PF14604 // ENSGT00390000017228_1_Domain_1 (1109, 1157)

HPEGELPLAAGDYIYIFGDMDEDGFYEGELQD
GRRG--LVPSNFV---EQIPDSYIPGCLPAKSP----DLG-------------PN--QLP
AGQD--------------EAL-EE---------D---SLL--S-----------------
----------------------------------GEAQGVVD---RGLC-QMVRVGSRTE
V-ATEILDTKM-EACQLGLLQGMGKQGL------------SRPLLG---TKGVLHMAPMQ
LHLQNVTATSAKITWVYSSHRHPHVVYLDDREHALTPAGMSCYTFQGLCPGTHYRAQVE-
---VQLPWDLLQVYWGTMSSTITFDTLLAGPPHPPLDVLVER-HASPGVLVVSWLPVTIH
STGSSNGVQVTGYAVYADGLKVCEVAD---ATAGSTLLEFSQLQVSLMWQKVSVRTVSLC
GESLDSVPAQIPEDCFMC-HRWPETPPFSYT--------------------CGDTSTY--
----RVTFPVCP-------QK---LALAPLSAKAS----------PHNPGSCGE------
----PQAKF--------LEAF--------------FEEPPRRKSPV-SNLGSEGESPSSG
A------G-------------------------SQAQELAEAWE----------------
------------------------------------------------------------
-------------------GCRKDLLFQKSPQNHRPHS-VSDQPGEKEN---CYQ-H---
-------MGT---SKSLAPGFI-H-LH---------------------------------
---TKCGPRKEPCQE---------------------------------------------
--------KAVL------------ERVLRQKQ------------------------DAQG
FT-----------------------PPQLGD-SQQ---YASDFH------NILEE-----
---EQEALCLDL--------------WGTERQEERREPKPHSR------------Q-GQ-
ALGVKRECQLHEPSL---------------------------------------------
-------------------ALCPAPSAKVIKM----PRDSPQQLGMEANTPARVSVALSD
YNPLVMSANPKAAEEGLVFQKRQLLRVWGSQDTHGFYLSECNRQLGNIPGRLVAEMEVGT
EQTD--RRRRLPAQAHLPSLAHLEDFQGLTI----P-----QGSSLVLQ-----------
-----------------GNSKRL--PLWTPKIMIAALDYDPGDGQ

PF07653 // ENSGT00390000017228_1_Domain_5 (2506, 2612)

VGGQAKGRLALRAGD
VVMVYGPMDDQGFYY---------------------------------------------
-------------------GELGGHRGLVPAHLLDHISLHGH------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------MEQLTTFPPPGDP---GA---
----------------------------------------------MEPWALPAWQSWTP
---GQGDEPGDTAPSIADTP-TVLHIRELS--------------SQPQEAQSLGPAVGTD
PEGAEARLPSLRQQAGTSG-----------RGSP--RLEDE---------EVQ--A---L
PKATTNTSFGDRPNLELLRTLEELQQHCAILKEENQMLRNSSFPET-EEKVRRLKRKNVE
LSVIAKRLEERARKL-QETNWRVVSAPVPRP-------GASLELCRKALARQRARDLSET
ASALLAKDKQIAALQRECRELQARLTL-------V--GKE----GPQWLHV-RDFDRLLR
ESQREVLRLQRQIALRNQQEPPL-----R---------SPGPAISAR------------A
GAPA--PVAPGE----A----TPQEDVDSLPVVLGEP--EKQQRVQQLESELSKKRKKCE
NLEQEARKKQRRCEELELQLREAQNENARLVEENSRLTGRA--TEKEQVEWENAELRGQL
L--GVTQERDSALRKSQ--GLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLW--E
KQEEVLRLQQAQAEAK-REHEGAVQLLE-S-TLDSMQARVRELEEQCRSQTECFSLLAQE
LQAFRLHPGPLDLL---TSALGGSALGDHPPAPCCCST---PQPSRE---A-GPKDFDLP
PGSP-GRCTPKSSEPAP---------ATLTGVPRRT-AKKAESLS--NSSR---------
-----------SESIHNSP-KSCPTPEVDTASEVEELEVDSVSLLPA-A-----------
-TEGNLGGPRVQVYLARYSYNPFEGPNENP

PF14604 // ENSGT00390000017228_1_Domain_1 (1111, 1157)

EAELPLTAGEYIYVYGNMDEDGFFEGELMD
GQRG--LVPSNFV---ERVSDDDLLTALPLELA--DLSRS-------------SGPELSF
PSGGGGGSSSGGQSSGGHSQPRLEEE---DAGEELSLSPP---------PEGLGEPPAVP
YPRQLVVLKQLAHSVVLA---WELPP---ERVELCGFHICVN---GELH-QALGPGAPPK
A-VLENLDLRA-GPL-HVSVQALTSKGS------------SDPLRCCLAVGARAGVVPSQ
LRVHQLTATSAEITWVPSNSNVAHAIYLNGEECPPARPTTYWTTFCNLRPGTLYQARVEA
QLPPRGAWEPGWERPEQRAATLQFTTLPAGPPDAPLDVQIEPG-PSPGILIISWLPVTID
AAGTSNGVRVTGYAIYADGQKIMEVAS---PTAGSVLVELSQLQLLQVCHEVTVRTMSPH
GESADSMPAPIAPALA-SACSSTRVTCPS-----PRPSPEARTPLAPAPPGPGDPSSP--
---LQRPASHGT-------PGPPGGPPASPTREMP---KGVQE-DP--PPPCSQ------
-----------------EEVEAAVLGVSGERRPSQSTMGERDPGPSAPCWAAQKAEWTAG
E-AGSMVCS---TQGALTQR---VP--EACCGADPG--LRARPEREDTA--ELGVRLVNP
LVDHGRNSDLSDIQEEEEEE------EEEEEEELGSRTRAFQKQVA---GNSVRENGAKP
---Q----PDPFCETDSDEEILEQILELPLQQFCSKKLF-SIPEEEEEEDEED-------
NGEQE-KPGAGCSSQDPSPLEPVCLG-LGCEGRQPP----GLGRCPLS------------
-PELSRAR---DHLVDMPGL---VGGS-SRRRG-GS-----------PEKPPNRRRP--L
DPREHCSRLFSNG-GPQASAR----PAPSRERSGLPVIEAAKGGPEASGKGRPGTS----
-------------R-RYPHGRA----PESGL-ASCLSPKCLEIS------IEYDSED-EQ
EVDS-GGI-----SITSSCYPTDGEPWGTAPAGRPRGP----------------------
---LKVNSGPNPYPH--LPAWEKGEPERRGRSVPGRA------KEPPSRAA-DTGEARG-
QNSSGRKGPQR----RG--AWVPRPSTTEL----APLRSPP-ETLAHWDLPVRV

PF07653 // ENSGT00390000017228_1_Domain_3 (2335, 2396)

FVALFD
YDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGECGGQTGYIPCNMVAE

ENSGT00390000017228_1_Linker_3_5 (2396, 2493)

VAVDS
PTG----RQQLFQRGYLSPDVVLEGT--GNSPFVYSTTH-TAGPPPKPRRSKKAELEG--
-P----AQPFAGPPKV----V-ASAALKAPHP

PF07653 // ENSGT00390000017228_1_Domain_5 (2493, 2615)

MVAAFDYNPRENSPNMDVEAELPFRAGD
VITVFGSMDDDGFYY---------------------------------------------
-------------------GELNGQRGLVPSNFLEGPGPEVGS------PDREPR-TPQA
ESQRTRRR----RVQC--------------------------------------------
------------------------------------------------------------
-----------------------------------------------