ENSGT00390000016256_0 : Linker Region Query Results

------------------------------------------------MLPCKKRRTAVT
ESLQHKGDQ-EENSVGLESAV-QPESD--QVKDLRSVSLSWDPGHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTSVPILEGVDVAISQGITLPSLESFHPLNIRIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--GEPSEVVKEEGGKPQ
MHSE---GEIPSLPL--GSQSVKPGTQPRKSTQLDVCAFSQEKPPRT-LIHQPDEEIEDG
GLFI--PM-EEQDNEDSEKRRKKKKGTKRKRDGRGQ--EGNLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPSIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLANCNPNLNSEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDC----SPHKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNVTGT-TEIGSDRGLEKD----NSELGSETRYP
LLL--PKGVVLKLKPVANRFPRKAWRQRRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSNVVVRIPHLIQPATVLQTVPGVPPLGA----SGGDGFECPA-ALPA
LP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-AKASPCMKPAPVIH-PAPVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLP-IPSASEDK-AQVNVDIACA
VADGKNAFQGLEPKLEPQEVSPLAATVF--PKVEHSPGPPPADT----------------
---ECQEGLSENSAYHWTIVKT--EEGRKA----LEPLPQGIQESLNN-------ST--P
GVSEEIVKMEPEDPGEKIS----GSPE----HDICDDIKEE--HAVELDTGTPSEE----
LSSAREVNKQTVLQKEEERSQPTKTTLSSQ------EPPDEGVSGTDVSKGSS-KNASSL
MD-PEGMLSSPQGKPEDSSSVDGQSVGTPVGPEIGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEVESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AAGDSAEKPPSTSVSPE--TAPEVETSRTLP-------GENI
KAA----GKGRS--KHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQEWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCG-SK------VCDSKSYKSKELHELVGSSPHQEASPMP
GAKDAGQSKDVMEEEVPEERESSEATHSR-TVRTTRKGETPVSAGLAVGGTLPSPR----
--------------------EVTLTERL-LDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLPCAKASP------RLQK------EREGQK-AVGESEALMLVWDASETEKL----
-------------PGTVETPASFLNPVSSKT--RDAGRRHV-------------------
--------SGK-PETQERWLLSSRARVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAE-----------LFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

-----MQGHKAGEKLTWETNPDSLTPQFALSIMLFYFPDGWNRSGTCKMLPCKKRRTTPT
ESPQHQGNQ-EEGDLDLESPV-KPESD--QVKDLGSVSLSWGPNHGRAAGLEVQSVHDAG
NLLAMEDPSL---SSR-VLTQDANAPVLETLDVAISQGITLPSLEASQPLNIHICKGKLQ
ASSSRRGKKITLRPGLVTQEDRG----------DHPIAKEPFL--GEPSEEVKDEGGKPQ
MHSG---GEMPSLPS--GSHPVKSTAQPRKSSQPDVCAS-QEKPLRT-LAHQAEEEIEDG
GLFI--PM-EEQDSEENEKRRKKKKGTKRKRDGRGQ-EEGTLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQTMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQSEKVHQTLILDPAQRRRLQQQMQ-
QHVQLLTQIHLLATSNPNLSSEASTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-VDW----SPRKTVKK-----TAHEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTKFPKPLISKYLLTCKTARQL
--------TVRIKNLNLSRAPDNIIKFYKKTKQLPILMKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LQHIADGAREVGHVTGS-AEISSEPGLGKG----SSELGSETRYP
LLL--PKGVVLKLKPVANYFSRKAWRQKRSSVLKPL-IRP-SPSLQPSS-SSG-------
KTPVRSAQAEAPPSKVMVRIPHMIQPATVLQPVPGGPPQGV----AAGERFESPA-ALPT
TP--AEARTSFPLP-------EPQTLLSSAP---VP----KVMLPS-LGPSRFRKPCVKR
RASRRKG-AKASLCLKPAPLIH-PAPIIFTVPAATVKVVSLGSGCNMLQPVSATVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSIPPLIVSGNSVNLP-VPSAPEDK-AQVSVDIGCP
LAEGKNAFQVLEPKLEPQEPSPLCAAVF--PKEEHSPGPLPPDR----------------
---VCQEQLSESSAYGWTIVKT--EEGRQA----LEPLPQAFQESLTS--------S--P
EALEEIVKMEPKDPGEELS---AECAE----QDTHEDIKEE--HSVELNTGFPSEE----
ASGTREVKKQMVLQQEEERRQPAQTSSASQ------EPPDERNSG-DVGKGSP-RNASSA
TD-PEMVLSSPPGKPEDLSSADGQSVGTPAGPETGGEKDVPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AIGDPAEKPPTTFASPK--TAPEVETSRTPPG-------ESI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-AEWPDGAKDCACS
CHDG-GPDSKLKKSKRRSCSHCN-SK------VCDSKSYKSKEPHESVGSSPHREASPMP
GAKEAGQGKDAMEEEAPEERESIEASQSR-TGRSTRRGEMPVP-GLAVGSALLSPQ----
--------------------EVTFTDQLLLDGP-PPCSPETPQLPSTTETV-LYAAGSDQ
AGPEALSCPKAAS------RPQI------EEEGPA-AGGESEAPLLVWDASETEKL----
-------------PGTVEPPASFPSPDSSRT--GDLGRRQV-------------------
--------SGK-PDTPESWLPSSRAGTTTTADRVSPVHESSSSG-------IDTSD---T
SPKAPRGG-----LAKDSGVQGKGPA--GEPQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPSEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLLCKNRRTTMT
ENLQHQGGQ-KEDAIEMD-----------SVTDLQSVLLSWGAGHDKTAAA---------
-QAGGEQPSG---SCR-TLTQDAAFAGLEGVGVDLSPGAALHSLESSPVLNAPLGKGKFQ
SPDSRGGKKTALSSGPAPQEDRG----------DHLGQEESCS--GESNEEGQEAGGKPQ
MLSGE--V-LPSLLS--GIQAVKPVVQPRKSSPPDVCTSPQEKPIRT-VAPQAEEETEDG
GLFI--PM-E-QDNGEIEKKRKKKKGTKRKRDGKDQ-EEGTSTYDLKLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIQLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKTRLRQ----APEMAETDEESGPLSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VEELF------------------ETFQDEMGFSNMEDD--
----GPEEEEHVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQPQ-EV---------ERAKPRPEKVPQTLILDAAQRKRLQHQMQ-
QHVQLLTQIHLLAASNVSLSSEANATKIFLKELGVFAQSSIALHQPLKHTFHTWFQPCNL
MGAMQLIDDFSTHVS-IDC----SPRKTVKK-----PASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPTHKVTFT-KAEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPVERERYRL
LCWLEASLPSIQEE-LRHMAGGAREEAHVTGI-PEISAEQGVDKG----GAEVGRETQYP
LLL--PKGVVLNLKPVANKFSRKAWRQKRSSVLKPLLIRP-SPSLQPSL-NLG-------
KTPARSTQSEAPPSK-MFRIPPLIQPAIGTPSIPGVP-LGV----SALDSFESPVVFP--
-PVSPAVRPSFPLS-------DSQTLISP---APAP----KIMLPS-LGPSKFRKPCVRR
RPSRRKG-SKASPCLKTAPLI-PSAPVIFTVPATTVKVVSLGSGCNVIQPVNAAVAQSPQ
TIPITTLLVNPTPFPCPLNQPLVASSIPPLIVSGNSVNLP-VPSAPEVE-TPGSVDIACP
LVEGQSAFQSPVPKLEQQDQSPVCASVF--PKEEHSPGPPAANRESQEGLSEN-------
-------------CAYWTIVKT--EEGTQM----LEPPPPRIXX----------XXXXXX
XXXXXXXXXXXXXXXXXXX---XXXXX----XXXXXXXXXXXXXXXXXXXXXXXXX----
XXXXXXXXXXXXXXXXXXX--XXXXXXXXX------XXXXXXXXXXXXXXXXX-XXXXXX
XXXXX-XXXXXXXXXXXXXXXDGQLM-AISAVETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQXXXXXXXXXXXXXX-XXXXXXXXXXXXX---------------
---XXXXXXXXX-X----------------------------------------------
-X-XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXX--XXX-X-XXXXXXXXXXXXES--V
KAA---AAKSRSS--HR-----ARSKR-------------GSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHFPGKYEDFLQVIYEFETNTQRQTAVDLYKSL
QLLLQDWPQLLRDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQGCADCLPQEIAELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPSKIPTASKSKRRKEMGAQNHDKX-XXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXX-XXX-XX------VCDSKSCKSKEPQELVGSSPQRAASPGP
GAKEAGRGKDVMDEEASEEHASPEANQSR-PGRPSRKAEVPVPSGLAAGSTLAYPC----
--------------------EATV-PERLLDVP-RPGSPEIPQIPPKTGTG-LVTIGSNH
AGPEGLPCPSAPSR------PQK------DKH--QEVEGAEA-STPLWDTSKTEKS----
-------------SGTGEPAASFPSPVSSRT--RDVRRRQV-------------------
--------SAKVEAPE--SQPHSSGGSTE-AADRTPPAPASSSG-------MDTTE---T
SPKTSKGA-----LLKDAGLPGRGPEG--EHPLKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEGSSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTLI
SSPQHKDSQ-EETHLDLESAT-TPEPD--QITDLGTVSLPWGLSHVRTPGLDVQPMQDAG
DHTHKEDP-S---APR-LLAQDTDVAILEAIDVSNTQEINLPSLESSQPCNITVTKGKIQ
GTCLRRGKRIALRPGPAPRDDH-------------PNLKESSS-STEACEKINSESXXXX
XXXXX--X-XXXXXX--XXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX
XXX--XXX-XEQDGEEGEKRRRKKKATKRKRDGRSQ-EEGALAYDLKLDD----------
-----VLDRTLEDGAKQHNLTVVNVRNILHXXXXXXHVVAMMKAAISETEDLPVFE----
----PKMTRSKLKEVVEKGVXXXXXXXXXXX-XXXXXX-XXXXXXXXXX--XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXAEK
IT-TLPIRHISAEVVPMGPPPPPKPKQNKDSTFMEKLHAVDEELACSPVCM---------
---------------DSFQPLD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVENEXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXX-XXXXXX-XXXXXXX-----XXXX---------XXXXXXXXXXXXX--
----XXXXXXXXX---------------XXXXXXX-XXXXX--XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XHVQLLTQIHLLSSANPSLSSEANTTKMFLRELGTFAQSSVVLHHQFNPKFQTMFQPCNL
KGAMQLIEDFHSHIH-IDW----SPRKNVKK-----SXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXASLPSIQEE-LQHLANDAGESGNVSET-AEPGSETGLDKG----SLELRNENRYP
LLL--PKGVVLTLKPLAKRFCRRAWRQRRSSVLNPLLICP-SPSLQPGS-STG-------
RTPTRLTQSEAPPSKVVVRIPRLIQPATVLQSVPGPPPLGV----TGGDGFELPM-ALPS
VTP--ENGTCLPQT-------MSQTLLSPAPAAFQP----KVMLPA-LVTSKPRKTGTKR
GARKRER-TKASPC-KAAPIL-RPAPVILTVPATTVKVVSLSNGCNMIQPLGAAVAQNPQ
TIPITTLLVSPTSFPCPLNQPLVASSIPPLIVSGNPVSLP-VPPTSEDN-TQVKSDIPCP
PAEGKSTFAAMEPKLEPQELSALCSALS--PKEEHSPVPPTPAR----------------
----RPEDPIEGNAHSWTVVKT--MEGREV----LEPLPQTSWETIT----------FLP
GDLVEIVKVEPEDPGEEV----NGSPE----QNVCGEIKEE--VSVELDTGPAGEG----
ANSTQEVKKEAVLQEEE-RGETAEISSVPH------ETQGEGSTRGEVSKGSP-KNISSP
TNP-A-ALSSPLGKPEDSSSIDGQSVGTPAGPETGGEKDGPEEEEEEDFDDFTQDEED-E
EMSSASEESVLSVPELQXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX---X
XXXXXXXXXXX-XX----------------------------------------------
-----XXX----------XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXE-------SI
KAV----GKARS--SHR-----T-------------RSKRG-RTRASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALRHVPGKYEDFLRVIYEFESSTQRQTAVDLYNSL
QTLLHDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQGCADCLPQEIGELKTQMWQLLKGHDHLQDEFSVFFDHLRPVASRLGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEHPKMSTASKNKRRKEMGGQNHDKE-TEWPDGPKDCVCS
CHEG-NPDPKLKKNRRRGCSHCS-SK------VCESKACKNKEPHELLGASPPPEASPTP
DAKEAGRGRETGEE------EGLDEQDSS----PSRKGEMPVPAGLEMGRTLLSPG----
--------------------EGNPTEKAPLDVP-APSSPESPQHSPKTGLV-PNSIRSQA
GTESPW-PSPKLQ------TLSE-------AQQAGAMSGSG-------------KA----
-------------FSAADCPASTLSPLPSNT--TDVG-----------------------
--KGWASGQGK-PDIPNSWLHPGRIIK---TASRIPTILESP------PPVTTTSG---P
VHRVPVGGSS----KEDSGLHAR--GPEGEQQLKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSTISQQLGNKTPGEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDRGDLLSEEEPDE

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-----------------------------------------------------------K
-Q-K-T-Q-SQ-S-L-I-NT-S-F-A-G-S-Q-I---I-R-A-A-G-R-G-R--N-S-H-
R-A-R-N-K-R-G-S-R-A-R-A-S-K--D-T-S-K--L--------------LLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQIIYEFESSTQRHTAVDLYKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLVSRQTKKAQ-----------------------
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-------------PKLYTEVEVSSQRDPYPSETPGAVPESPGR--GSLQVAARNPTT---
------------------------------------MKPPKNSRAGE-WFQQSEEENLDL
GLF--ILF-EEQDGEDVERRKRRRKASKRKREGKSPEEESSLSCDIKLDE----------
-----SLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETEDIPLFE----
----PKMTRSKLKEVVEKGGVIPTWNISPIK-KANEMK-PPQFVDIPLE--EDDSSDEEY
QPDDEDEDETAEESLLESDVESTASSPRGA-----KR----SRTRRSSDEEGGTLCEMEK
VT-TPVVRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSYQPLE---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEEWKRWLGGLMNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDE--
----GPEDEDVVA---------------ESRPNFN-TPQAL--RFEEPLANLLNKQHRTV
KEQLEQLRMKKSSMKAAQ-ES---------EKSKPPNEKPLQNLVLDSAQRKRLQQQMQ-
QHVQLLTQIHLLASFNPALSSEANTTRMFLNELGSFARSSSLLRVPLNPKFQTMFQPCNL
QGALQLIEDFHAQVP-VDC----SPRKAVKK-----NTNDFSCLPKQVAWILATRKVFMY
PEL-LPVCSLRANPHRDKIVFT-KAEDNLLALGLKHFEGIEFPKPLISKYLLPTKTAHQL
--------TVRIKNLTMNRAPDNIIRYYRKTKQLPVLLKCCEEIQPHEMKAPVEREEHRL
PFWLKASLPSIQAE-LKQLAEDTKDAPASPDA-EPAIL--GSEKE----TSDTECDDKYP
LLM--PKGLMLTLKPLANRFSRRAWRRQKSAALKPVLIRP-NPCLQPSS-SPA----SIQ
K-TLKLSQAEAAPSKVLLKVPRPIQPAP------LVQPLNVPAVVGGGDGLEFQN-VLPS
AHP--DSRQAFPAA-------VSPALVSSEAATLQP----KP-PPA-SAGTKTHKPCVGK
GSQRKKG-TKSAPVITPSPVI-QPSPVILTVPATTVKVVNIGNGCNMIQPLNPAVGQGTQ
AIPVTTLLVNPSTFPCPLNQPLVTSSIPSLIVSPSPVGLS-AAAVKSEGEEQLTLLPAP-
-----AAFPKVEPKVEPPELFVPCCAVS--PKEEGGTSPGTPHDGTQDKGDKGD------
-------------CCSWAVGEG--EGNTS-EPLPV-ELLPHSKD----------------
--PDKSVKIESEDSSDDPK---EANLAQ-KKDLLCAEGKEE--FMLGLGQELNMEAACSC
GDEP---KKEQLPCE--EKG-EEERQTLPSPPQAEQQGEPGGAAGPAGSSDSP-KNLPCP
AEGEA-EFSSPPGRPEDSSSIDGQSVGTPAGPEAAGDREGQEEEEEDDFDDFTQDED--E
EMSSASEESILSVPELQETMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEE--
GEGMESLQKDD-ET----------------------------------------------
-------------------CGDPSEEPKSDFTTAKE-ASPQVETHRMAAGE-------NL
KAP----GKSRS--SHR-----T-------------RNKRG-RARGSKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLSRVRETLQHIPGKYEDFLRVIYEFEISTDRRTAVDLYCTL
QKVLHDWPQLLTDFAAFLLPEQALECGLFEEQQAFEKSRKFLRQLEICFAENPAHHQKII
K-VLQSCADCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEDDEPPKIHGANRNKKRKEIGGQQQDKE-LEWVDGLKECSCS
CHEG-SGDLKLKKSKRRSCNHCS-SK------VCESKFYKNKDSQELPASLAQAESSPQP
EGKDPGMSKEAGEE-SLESREEGEDVQSR-TRPGSRKVESLSPG---------------N
ALFK-SSSLPHRAS--LTLF---GFLLRTSPGS-RPGSGEKPAQVP------------EG
AGAAVDDAKDRPQLQKTALKLPQETKECPCTEGLKQPGGNSA-E-----------NS---
---L------LLSAA--------------PMQSQTEGLHPE---PKPRGAAK-ELQG---
--AAASPLQGR-AETEQSWSTRSSRTALSESCRLDCQHRAAPEG----SSGSSSSQ----
------------QQQ--EARAGPG--PREQQQQRVAEATVCAKNSKVSSTGEKVVLWTRE
ADRVILTSCQEKGAHLDTFHAISQKLGNKTASEVSH-RFRELMRLFHTSCDGSSEDEEDA
TSTSNTDQLSDKDLLLSEEEPDD

------------------------------------------------MLPCKKRRTTLT
ESPQHQGNQ-EEDDLDLQSAV-KPESD--QVKDLGSVSLSWSPSHGRAADLEV---QDAG
IQLGMEDPSL---SSR-MLTEDTNVAVLEAVDVAISQGLTLPSLESSQPVNTHLGKGKLQ
ANSSRRGKKITLRPGSATQEDRG----------DHPIAKESFS--EEPSEEVKEEGGKSQ
MHSE---GEMPSLPS--DSHSAKPAAPPRKSSQPDVCASPQEKPLRT-LAHQAEEETEDG
GLFI--PM-EEHDSEENEKRRKKKKGTKRKRDGRDQ-EERTLSCDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFV----
----SS---------------------------SCSFS-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-APAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQREKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLASCNPSLSSEASTTRIFLKELGTFAQSSIALHHQFNSKFQTLFQPCNL
MGAMKLIEDFSTHVS-VDW----SPRKTVKK-----TACKLPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPILMKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-MRHIADGAREVGNVTGT-TEINSDPGLGKG----SSELESETRYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSTLKPFFFGP-SPSLQPSS-SSG-------
KTPARSAHSEAPPSKMVVRIPPLIQPATVLQAVPGGPPLGV----PGGDSFESPA-ALPA
TA--AEARTSFPLP-------EPQTLLSSAP---VP----KLMLPS-LAPSKFRKPCVKR
RASKRKG-PKASLCLKPAPLIR-PAPVFFTVPATTVKVVSLGGGCSMVQPVSAAVAQSPQ
TIPITTLLVNPAPFPCSLNQPLVASSIPPLIVSGTSVNLS-VPSTPEDK-APVNVDIGCP
LTEGKNAFQGLEPKLEPREPSPLCAAVF--PKEEHSPGPPAIDR----------------
---VCQEQLSESSAYGWTVMKT--EEGRQA----PEPLPQGFRESLNT--------C--P
EDLEEIVKMEPKDPGDDTC---GGSLE----QDSHDEIKEE--RSVELDTGFPSEE----
PGRPREGKKQTGLQQEEERSQAAQTLSASQ------EPPGEGNSG-DVSKGSP-RDASFS
TD-PEMVLSSPLGKPEDLSSVDGQSVGTPAGPEAAGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMENLQKED-EM----------------------------------------------
-----MDE----------AIGDPAEKPPATLDSPK--AAPEVETSRTPPG-------ESI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-AEWPDGAKDCACS
CHEG-GPDSKMKKSKRRSCSRCS-SK------VCDSKSYKSKEPHELVGNSPHREASLMP
GAKEAGQGKDVMEEEAPEERDGTEATQSR-TGRSTRKGEMPVA-GLAAGSTLPSPQ----
--------------------EVTFTDQL-LDGPPPPCSPETPQLPSTAGTV-LCAVRSNQ
AGPAVLSGPRASP------RPQY------EGEGHK-PGAELEP-SMPWDASETEKL----
-------------PGTVEPPASFLSPVSSRT--GDFGRRQV-------------------
--------PGK-ADTQESWLPSSRAGVTTA-DRVSPLRGVSSAG-------IDTAE---T
SPKAPRGG-----LAKDSGLQGKGPA--GELQAKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSVISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTLT
ESPQHQGNQ-EEDDLDLQAAG-KPESDLGSVKDLGSVSLSWSPSHGRAADLEV---QAAG
IQLGMEDPSL---SSR-MLTEDTNVAVLEAVDVAISQEITLASLESSQPVNTHIGKGKLQ
ATSSRRGKKITLRPGSVTQEDRG----------DHPIAKEPFS--EEPSEEVKAEGGKSQ
MHSG---GEMPSLPS--DSHSAKPAAPPRKSSQPDVCASPQEKPLRT-LAHQAEEETEDG
GLFI--PM-EEHDGEENEKRRKKKKGTKRKRDGRDQ-EERTLSCDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQREKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPSLSSEASTTRIFLKELGTFAQSSIALHHQFNSKFQTLFQPCNL
MGAMKLIEDFSTHVS-VDW----SPRKTVKK-----TACKLPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPILMKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRRIADGAREVGNVTGT-TEINSDPGLGKG----SSELESETRYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSTLKPFFFGP-SPSLQPSS-SSG-------
KTPARSAHSEAPPSKMVVRIPPLIQPATVLQAVPGGPPLGV----PGGDSFESPA-ALPA
TA--AEARTSFPLP-------EPQTLLSSAP---VP----KLMLPS-LAPSKFRKPCVKR
RASKRKG-PKASLCLKPAPLIH-PAPVFFTVPATTVKVVSLGSGCNVMQPVSAAVAQSPQ
TIPITTLLVNPTPFPCSLNQPLVASSIPPLIVSGTSVNLS-VPSTPEDK-APVNVDVGCP
LAEGKNAFQGLEPKLEPRELSPLCAAVF--PKEEHSPGPPAADR----------------
---VCQEQLSESSAYGWTIVKT--EEGRQA----PEPLPQGFRESLNT--------C--P
EDLEEMVKMEPKDPGEDTC---GGSLE----QGSHEEIKEE--HSVESDTSFPSEE----
SSRPREGKKQTGLQQEEQRSQAAQTLSASQ------EPPGEGNSG-DVSKGSP-RDASFS
TD-PEMVLSSPLGKPEDLSSVDGQSVGTPAGPETAGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMENLQKED-EM----------------------------------------------
-----MDE----------AIGDPAEKPPATFDSPK--AAPEVETSRTPPG-------ESI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPS HHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTTSKNKRRKEIGVQNHDKE-AEWPDAAKDCACS
CHEG-GPDSKMKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASLMP
GAKEAGQGKDVMEEEAPEERESVEAAQSR-TGRSTRKGEMPAA-GLAAGSTLPSPQ----
--------------------EVTFTDQLLLDGPPPPCSPETPQLPSTAGTV-LCAVRSNQ
AGPAVLSGPRASP------RPQH------EGEDHK-PGAELEP-SMPWDASETEKL----
-------------PGTVEPPASFLSPVSSRT--GDFGRRQV-------------------
--------PGR-ADTQESWLPSGRAGVSTA-DGMSPLRGVSSAG-------VDTAE---T
S-KAPRGG-----LAKDSGAQGKGPA--GELQAKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSVISQQLGNKTPTEVSH-RFRELVQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MVPSKKRRTAVT
ESPQHQGIQ-EDSDLDLELAD-KPGSE--QVESLGSSSLP--------QGLETPSVQDAA
YPLGVEAPSL---SSG-LLTQDAGAPVPEAVGVAAPKGSALASPESSRPRDTHTGKENLQ
AAGAKRGKKMTLRPRPVPQEDRS----------DPPVTKEPFP--GEPGEDVQGE-GRPQ
AHSG---GALPWLQD--SQ--PARGAQPRPSAQPDVRAPPPEKPLGT-CARQAEEEGEDG
GLFI--PM-EEQDDEESEKRHKKKKGTKRKREGRGQ-GEGTLADDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEVK-PPQFVDIHLE--EDDSSDEEY
QPDDDEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGMLSEAEK
VT-PPAVRHISAEVVPMGPPPPPKPRQTRDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKLWLGGLMSDDVGNEDEADDDDDPEYNFLEDR-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFE---------TFQDEMGFSNMEED--
----GPEEEGRPA---------------EPRPTFN-TPQAL--RFEEPLANLLNEQHRTM
KELLEQLKMKRPSARQQQ-EV---------ERVKPQGEKAQQTLVLDPAQRRRLQQQMQ-
QHVQLLTQIHLLSTFNPSLNSEASTTRIFLEELGTFAQSSVALH-PLNPKFQTLFQPCNL
MGAVQLIEDFNTHVT-VDW----SPRKAVK------TACKFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKNSFT-KAEDNLLVLGLKHFEGTEFPKPLISKYLLPCKTAHQL
--------TVRIKNRSMNRAPDNIFKFYKKTKQLPVLGRCCDEIQPHQWRPPVEREEHRL
PFWLKASLPSIQEE-LQRMADGVQEPGHVTGT-AEVKPDPDLGKG----SSGPGGETRYP
LLL--PKAVVLRLKPVANCFSRKGWRQKRSSALKPLLIRP-SPSAQPSS-SSG-------
RAPARSAQAEAPPGKTMVRIPPAIQPATVLHAVPGGPPLGV----TGGDSFESPA-ALPV
MP--PEARSSFPLS-------EPQTLL-SAP---TP----KVMLPS-LAASKFRKPYVKR
RGPKRKG-VKASLCLKSVPLIN-SAPVIFTVPATTVKVVSLGSGCNVIQPVNATVAQTPQ
TIPITALLVSPAPFPCPLNQPLAGSPTPPLVVSGGSVDPP-VRPTPADK-AQVVLDTSCP
LGEGESAFPGLVPKSEPRELSPLCTTVC--PKKECSPGPVAADR----------------
---ACREDLSGSGAYVWTVVKT--EGGGQV----VEPLAQGFQPSLNS-------L---P
GDMEKVVKMEPKDPGEEVS---SGSPE----PAVCGGIKEE--HSVDVDAGFPREA----
PGGAAEARKQASHR--EEKGRPARSPAASQ------GPPTAGDSG-DGSREYP-ENAPSS
TD-PEGVLTSPPGRPEDIPSADGQSVGTAAGPEAGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-VSQEGESEEENSQEDNSEPEEEEEE--E
AEGMDSLQKED-GA----------------------------------------------
-----ADG----------AIGGLAEKPPAPFASPE--AAPEAETSRTPAXXX---XXXXX
XXX----XXXXX--XXX-----X-------------XXXXXXXXXXXXXXXXXXXXXXXX
XXX---XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
R-VLQSCADCPPQEATELKTQMWHLLKGHHHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEAPKTPTASKSKRRKEIGVQSHDKE-ADWPDGAKDCACS
CHEG-GPDSKLKKNRRRNCSHCS-SK------VCDSKSYKSKEPHESGGGSPHREASPPP
GAKEARLGKDGMEEEAPEGREAAEAPPGR-PSRSSRRGEVPAPAGLATGSTSLAPQ----
--------------------ETTLTDQQLFPDGPPPSSPETPQCPPDAGAA-PDT-TASQ
PGPKAPPCPDVSP------GLQG------GRLGLS-AAGESEASVPIWGTSETERR----
-------------PGTVGPPAPFPSPVPSGT--RDFGRRQV-------------------
--------SGK-PDHCEGWLPVGRAGAQTS-DEKAVAHESSRSG-------SDTTE---T
FPRAPRGG-----LATDSGLQGRGPE--GEQLPKVAEVTVCANNSKVSSTGEKVVLWTRE
ADRVILTVCQEQGAQPQTFRVISQQLGNKTPAE---------------------------
-----------------------

------------------------------------------------MLPCKKRRLSVT
ESSQQQDDQ-EGDDLDLEAAV-KPDTD--QLPDSASESLSWGQSQDSAVCPEGLSMQDGD
DQLRAEGLSL---NSK-MLAQHVNLAVLEAVDVAVSQEIPLPSLESSHSLPVHVDKGRLQ
VSASKKGKRVVFTPGQVTREDRG----------DHPVPEEPPS--GEPAEEAKTEGGELE
LRSD---GEVPLLSS--SSQSAKPGAQPRKSVQPDGSAFPQDKPLGP-LVRQAEEEMEDG
GLFI--PT-E-QDSEESDKKKKTKKGTKRKRDGKGP-EQGTMVYDPKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGV------------------QPPQFVDIHLE--EDDSSDEEY
SPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRL----SSEVAETDEESGMLSEVEK
AA-TPALRHISAEVVPMGPPPPPKPKQSRDSVFMEKLDAVDEELASSPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKQWLGGLINDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFETVQSV-VPSKFQDEMGFSNMEDD--
----GPEEEERAT---------------ESRPSFN-TPQAL--RFEEPLANLLNERHRTV
KELLEQLKMKKPSVRQQP-EV---------EKLKPQEEAAHQTLVLDPAQRSRLQQQMQ-
QHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGTFAENSIALHQQFNPRFQTLFQPCNW
MGAMRLIEDFT-QVS-IDC----SPHKTAKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKTIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRL
PFWLKASLQSIQDE-LRNISEGATEGGSVTTA-TESSTDQHLQKA----SPALGDEPQYP
LLL--PKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQP-SPSVQPVF-NPG-------
KMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGV----RGEDGFESPT-ALPA
MPCGSEARTTFPLS-------ETQSAPPSCS---AP----KLMLPS-LAPSKFRKPYVRR
KPTRRKG-AKVSPCVKPAPIIH-PTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQ
TIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLP-VTSIPEDK-AQVKLDVA--
--EGKNAPQNPESKLKPQELTPLCTTVF--SKEEPKSWHSSADTGSQEAFSESSACSWAV
VKTESQEGSSEKSACGWTVVKT--EDGGHA----VEPLPQNLQDSLSS-------S---S
KDLLNMVKMEAQDCMVEIS---SNFPK----QDIGEEVKEE--CSMELDSESPQEK----
PSSASEMSKQTVLQRED--MQAAKSPSVPQ------DAAAEGRTSSHASRGLP-KSTLSS
MG-QGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMETLQKED-EV----------------------------------------------
-----NDE----------AVGDAAKKPPSTLASPQ--TAPEIETSIAPAGE------S-I
KAA----GKGRS--SHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVILPDVEEDEEPAKVSTASKSKRRKEIGVQHQDKD-TEWPEAAKDCSCS
CHEG-GPESKLKKSKRRNC-HCS-SK------VCDSKPYKSKEPPELVGSGPLHEASTVP
GSKEAGQGKDMLEEEILEEQENMEVTQSK-TARTTRKGEAPAP-GSTIGSTLLCPA----
--------------------EVTPMELLLEG--PALCSAETPRLPPQTGAV-VCSVRRNQ
AGPEVVSCLSTSS------LPPE------EGEDQR-AAANSETIAPHREASETERL----
-------------PETVEHSAPLPSPVSTRT--RDTGRRHI-------------------
--------CGK-AGS-QSWLIESRAEAEAA--HVAAPICEKSSG-------ARASE---A
APKTAREV-----LAEDSGTQGMGPE--GA-LPKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAA-KPESD--QVKDLRSVSLSWDPRHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPMLKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PMVTL----------------------------GVL------------------
--------------------------RYKIKLITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEISSDHGLEKD----NLELESETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALTA
MP--PEGRTSFPLS-------ESQSLLSSAP---VP----KVMLPS-LAPSKFRKSYVRR
RPSKRRG-IKTSPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQNPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-ARVNVDIACA
VANGENAFQGLTPKLEPQELSPLSATVF--PKVEHSPGPPPADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--A
GDSEEVVKMEPEDAREEIS----GSPE----HDICDDIKEE--HAVELDTGVPSEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSVTDVNKGSS-KNASSS
MD-PEVRLSIPPGKPEDSPSVDGPSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEDSVSENKQKKRIRPP---------
------------------------------------------------------------
-------------------------RPPKVLGLQA--R-GLGTEKQSFSCVL---QGESI
KAA----GKGRN--NHR-----V-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGGTLPSPR----
--------------------EVTLPERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEKL----
-------------PSTVEPHASFLSPVSSNT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAE---------------------------
-----------------------

------------------------------------------------MLPCKKRRTTVT
GSPQHQGSQ-EEEDLDLESAV-KPVSD--QVKDLGSASLSGGPSHGRAAGLQVQSVQEAG
NQLGEEDPPL---SSR-VLTQDTNAPVLEAVDAAISQGIALPSLESSQPLIVHTGKGKLQ
APGSRRGKKIALRPGPVPQEDRG----------DHPVTKEPFS--GEPSEEVKEEGGKPQ
--SG---GEMPSLPL--GAHSAKPGALPGKSPPSHVCACPQEKPLGT-LAPQAEDETEDG
GLFI--PM-EEQGNEESEKRRKKKKGTKRKRDGRGQ-EEGTWACDLKLDDVL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---AS-EVTETDEEGGVLSEAEK
VP-TPAVRHISAEVVPMGPPPPPKPKQSRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGLSNVEDD--
----GPEEEERVA---------------EPRPSFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLKVKKSSGRQQQ-EV---------ERAKPQNEKVHQTLTLDPAQRRRLQQQMQ-
QHVQLLTQIHLLASSNPNLTSEASTTRIFLKELGTFAQSSVALRHQFNPRFQTLFQPCNL
PGAVQLVEAFSTHVS-VDW----SPRKTVKK-----TADEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTKFPKLLMSKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPILVKCCEELQPHQWRPPVEREEHRL
PFWLKASLPSIQEE-LWRRADGARGVGGVTGA-AEVSSEPGLGTG----SSELGSETPYP
LLL--PKGVVLKLKPVANCFSRKAWRQKRPSVLKPLLIRP-SPSLQPGS-TPG-------
KTPARSTPPEAPPSKMVVRIPHVIQPAAVVQTVPGVPPPGA----PGGDSFESPT-ALPS
TT--PEARTGFPLS-------EPQTALPSAP---VP----KVMLPS-LAPSKFRKPCARP
RASKRKG-AKASLCLEPASLIH-PVPVIFTVPAATVKVVSLGSGCNVIQPVSAAVAQSPQ
AIPITTLLVNPTSFPCPLSQPLVASSLPPLIVSGNSVSLP-VPPAPEDK-APVSVDISCP
LAEGKNAFQGLEPKLEPQELSPLCAPVF--PKEEHSPGPPAADR----------------
---VCQEELSENSACGWTLVKA--EDGGQG----LEPP-LGSRESLST-------P---P
RDLEDVVKMEPKDPGEDA----------------CEDSRAG--CSVGLDAGFPGEE----
PRRP-----PVLQQEEEEGSQPARTSSASR------EPRDEGHSG-AVSKGSP-RTASSC
AD-PDAARSSPPGKSEGFASADCQAAGTPAGPEAGAEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-AGQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AAGDHAEKPPATFASPR--TAPEAEAGSAPPG-------EGG
RAA----GKGRS--SQR-----A-------------RGRRGGRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALRHAPGKYEDFLQVIYEFESSPQRQTAVDLYRSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQSCADCLPQEISELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRLGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKMPTASKSKRRKEIGVQNHDKE-AEWPDGARDCACS
CHEG-GPDPKLKKSKRRGCSRCS-SR------VCDGRSYKSKEPHESAGGSPHREASPVP
GAKEAGQGKDLLEEEVPEERESVEAAQGP-PGR----GALPVP-----GSAVGSTQ----
--------------------EVTLTEQLVLGGP-PPCSPETPQLSSSPGVV-LCVVRRNQ
AEREVLPCPEASP------RLRN------EGEDQE-AVGEPEASVPAWDASETEKW----
-------------PGTEENPASFLSPVSSRT--RDLGRRRL-------------------
--------SEV-SDSPGSWLLSSRAGVKTA--HRMSPVHESLSG-------TDTSE---T
SSQAPRGG-----LVKDCGVQGKAPV--GEQQPKTTEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSVISQQLGNKTPSEVSH-RFRELMRLFHTACEASSEEEEDA
TSTSNTDQLSDRGDLLSEEELDA

------------------------------------------------MLPCKKRRTTVT
ESPQHHGSQ-EGEDPDLESVV-KSSSD--QVKDWGSASPSGGLSHGRVAGLEVESVQDAG
SQLAGEDSCL---GSR-GLTQDTDAPVLEAVGAAVSQGLTLPSLETSQPLRVHIGRGRVQ
AAGSRRGKKITLRPGLVPQEDRG----------DHPLPKEPFS--GEPSEEVQEEGGEPH
LHSG---GVMPSPPL--GSHSAKPGAQPGKSPQPGVCGCPQEKPLGT-LAPQVEDETEDG
GLFI--PM-AERGGEGSERRRRKRRGTKRRRDGRGP-EGGAWTCDLKLDAALDRTLD---
----RTLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KASEIK-PPQFVDIQLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRP----SSEMTETDEEAGVLSEAEK
AS-APAVRHISAEVVPMGPPPPPKPKQSRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLVNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGLSNVEDD--
----GPEEEERAA---------------EPRPSFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLKLRKASGRQVP-EA---------ERAQPPVEKVRQTLTLDLVQRGRLQQQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTRIFLKELGTFAQSSIALH-QSIPGFQTSFQPCNL
LGAVRLVEDVSAHIS-VDW----SPRKAVKK-----TADEFPCLPKQVAWTLATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTKFPKLLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTRQLPVLLKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LWRRADGARGAGNGTGT-AEGSSEPDLGKG----SSDLGSESPYP
LLL--PKGVVLKLKPVANCFSRRAWRQKRPSVLKPLLIRP-SPSLQPSS-TAG-------
KTPARSAPSEAPPSKMVVRIPHVLQPATVVQTVPGVPPLGV----RTGEAFESPA-ALPP
TA--PEARTSFPLS-------EPQPLLSSAP---VP----KLMLPS-LAPSKFRKPCAKP
RASKRKG-AKGSLCLEPASLLH-PVPVIFTVPATTVKVVSLGSGCNVIQPVNAAVAQTPQ
TIPITTLLVNPTSFPCPLNQPLVASSLPPLIVSRSSVSLS-VPATPEDR-APVNVDIGCP
VAEGKNAFQGLEPKLEPQEPSPLCAPVF--PKEEHSPGPPAADR----------------
---VSQEERPENRACGWALGKAEGEGGRQA----LEPLP--------------------P
GDLQEMVKMEPQDPGEGDS---SGSSG----QDTCEDIREE--HSVALDAGFLGEE----
PSGPSELR-QPALQQEDERREPARAASASR------EPRDQGDSG-DGSRGSP-KTASSC
AD-PKGVRGSPPGKSEDLASASGQTRVTPAGPEAGGEKDGPEDEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-AGQEGESEEDNSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDPAEKLPATFASPG--TAPEAEASSAPAG-------ERG
RAA----GKGRG--RRR-----V-------------RSKRGSRARANKDTSKLLLLYDED
LLERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIHEFESGTQRQTAVGLYRSL
QALLQDWPQLLRDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPS HHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQEEFSVFFDHLRPAASRMGDFEEISWTE
EKEYEFDGFEEVALPDVEDEEEPPKTPAASKSKRRKETGVQSHDKE-AEWPDTAKDCACS
CHDG-GPESRLKKSKRRSCGHCG-GRVSAAAAVCDSKSYKSKEPQELAGSSPHREAS---
--------KDLQEEAAREECEGPEANQDQ-PGRSAGGGGTPVP-GLAVGSTPLSPQ----
--------------------EASLTDRLVLGGP-RPYAPEMTQLSSSTRAV--C-AGRSQ
ASPEDLSCPRASS------RLPT------QGEDQE-AVGEPEASVPAWAASEMEKW----
-------------PGTVETPASFLSPVSSRT--RDMGRRQM-------------------
--------SER-SDAPESWLLADTATVRTA-DKTSPVCDS-SLG-------TDPSE---S
SSMAPRGA-----LAKDSGTPGKGPM--GELHLKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQQQGAQPQTFRGISQRLGNKTPTEVSH-RFRELVQLFHTACEASSEDDDDA
TSTSNADQLSDRGDLLSEEELDG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------EVITNEHVVAMVKAAISETEDIPLFE----
----PKMTRSKLKEVVEKGGVRFPFELQGWSPSFSCVQ-PPQFVDIPLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGA-----KR----CRTRRSSDEEGGTACEVEM
AT-SPVVRHISAEVVPMGPPPPPKPKQSKDSTFMEKLHAVDEELACSPVCM---------
---------------DSYQPLE---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPS----TADDEEWKRWLRGLMNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFETVSDKLKNGAFQDEMGFSNVKDE--
----RPEDEDAVT---------------ESRPNFN-TPQAL--RFEEPLANLLNKQHQTV
KEQLEQLRMKKSSIKAPQ-EA---------EKCRTTNEKPLHSLVLDSAQRKRLEQQMQ-
QHVQLLTQIHLLASFNPALSSEASTTQMFLSELGSFACSSTLHQVPQNPKFQTMFQPCNL
EGALQLIKDFHAQVP-VDW----SPRKAVKK-----NANEFSCLPKQVAWILATRKVFMY
PEL-LPICSLRANPHRDKIVFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLPTKTAHQL
--------TVRIKNLSMNRAPDNIIMYYKKTKQLPVLVKCCEEIQPHEWKPPVEREEHRL
PFWLKASLPSIQRE-LKQLAENAKGTPASPEG-ESALL--GPEKE----ASNTEYGDKYP
LLM--PKGLVLTLKPLANRFSRRAWRRQRSSALKPVLIRP-SPCLQPSS-SPL----NVQ
K-TPKLSQSEAPPSKVLRQVPRPIQPAP--------QPLNVPAVLGGGDALEFQN-VPST
AHP--NSRQTFPAA-------VPPALVSSEAPKLM--------LPA-LAGTKTRKPCVRK
GYQRKKG-TRSTPLIKPSPLI-QPSPVILTVPAATVKVVNIGNGCNVLQPLSTAVGRGAQ
AIPVTTLLVNPSTFPCPLNQPLVTSSIPSLIVSPSPVGLA-APAV-GEGEEKLTLLPAP-
-----AAFPTAEPKAEPTELFVPCSSLV--PEEESGTN--AAHGDTQDQGSKAD------
-------------CCSWPGAEG--DGHTP-KPVPVVELLPRLEA----------------
--ADPSAEIKSEDLNDAPK---EAKLAQ-RKDFLCAERKEE--FMLGLGQELNMEAACCC
GDEP---KK--------EKG-EEERRALPSPARGEPQGDAGGA---AGSSDSP-KIPPCP
AEREA-ELSSPPGRPEDSSSVDGQSVGTPAGPEAAGEREGQEEEEEDEFDDFTQDED--E
EMSSASEESVLSLSGLLSTMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEE--
GEGVENLQKDD-EI----------------------------------------------
-------------------CGDPAEEPKSAFTTAKATSSPQLEAQGMPAGE-------NL
KAP----GKGRS--SHR-----T-------------RSKRG-RARGSKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVRETLQHIPGKYEDFLRVIYEFEIGTDKRTAVDLYCTL
QQLLHDWPQLLTDFAAFLLPEQALECGLFEEQQAFEKSRKFLRQLEICFAENPAHHQKII
K-VLQSCADCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEEDEPPKIHGATRNKKRKEIGGQQHDKE-VEWVEGMKECSCS
CHEG-SSELKLKKSKRRSCSHCG-SK------VCENKFYKNKDCHELPASLAQPESSPQP
EGKEAGMSKEAGEE-ILEGREEGED---R-TKPGPRKGESLSPG---------------V
ECSA-LFTMI-------APF---KLLF---PGC-CSSSQSL---PP------------TG
ARAQLVLLH----QAAPKHAALNSTKECPCSEGLKQPAGNAE-A-----------PP-GL
GRDL------LLSAA--------------AK--SSLGPRPS---EQPRGSAL-GPGGGKG
LEGASLALEGR-AEAKQGWITKSSKAAAGESCSSASPAAAASE-----------------
--------------T--QDRGCTG--AAAEGRPRVTEATVCAKNSKVSSTGEKVVLWTRE
ADRVILTTCQEKGAHLDTFHAISQKLGNKTASEVSH-RFRELMRLFHTSCDGSSEDEEDA
TSTSNTDQLSDKDLLLSEEEPDD

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSLVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLSQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHLILKEPFS--EEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PV-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEMK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLKQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KDLFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKVQPSSSKSM------GGRRS-----------------------------------
------------------------------------------------------------
-----------------L---------KVLREYQ--------------------------
------------------------------------------------------------
------G-L-----------------------------------------SVQLWPRVPK
TIPITTLLVNPTSFPCPLNQPLC------------------------DK-AHVNVDLACA
VADGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGRPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEDATEEIS----GSPE----RDICDDIKVE--HAVELDTGAPSEE----
LSSAREVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDAAEKAPSTFASPE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTTVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHEVVGSSPHREASPMP
GAKEAGQGKDVMEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNH
VGPEVLSCPKASP------RLQK------EREGQK-AVSESEALMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRMCPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRATVT
ESVQQGDDQ-EGDDLDLESAV-KPESD--QLKDLGSESLSWGPGHESAVCPELHSMHDVE
NQLSMEDPSL---SSK-MLTQHGNLPVLEAVGVAIPQDITLPSLESSHSLTVHIDQGRLP
ATGSKKVKKTAFQPGLMTREDQG----------DHPVIVEPPS--GEPGEEVKAEGGKLQ
MHSGG--E-LSLLSS--GSQSAKPGAQPRKPFQTDGSALPQEKPLRT-LVHQTEEEMEDG
ELF--IPM-E--------------------------------------------------
-------------------------------VITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGV----------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------PME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKVWLGGLLNDDVENEE-------------------
-----------------KE-VNGLMEE-----LFET---------FQDEMGFSNMEED--
----GPEEEERVP---------------ESRPDFN-TPQTL--RFEEPLANLLNERHRTV
KELLEQLKMKKSSSKPQP-EV---------ERLKPQKETVHQALILDTAQRSRLQQQMQ-
QHVQLLTQIHLLTTSNPNLSSEASTTRVFLKELGTFAENSIALHQQFNPKFQTLFQPCNW
MGAMQLIEDFA-HVS-VDC----SPHKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNQNRAPNNVIKFYKKTKQLPVLMRCCEETQPQQWKPPVEKEEHRL
PFWLKASVQSIQDE-LRKTAEGVEEGATVPRA-TEAGTDQHLEKA----CPELGSETRYP
LLM--PKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQP-SPCVQPGF-NPG-------
KLATWSTPSEVPPGNRVVQIPHLIQPATVLQPLPGFSSVAV----SGEHSFESSA-ALPT
MPSGPEARTNFPLS-------ESQSPMPSSS---AP----KIMLPS-LAPSKFRKPYVRR
KPTRRKG-TKVSPCVKAAPII-HPTPVIFTVPAATVKVVSLPSGCNVIQPVNAAVAPNPQ
TIPITTLLVNPTSFPCPLNQPLVASSISPLIVSSNPLTLP-VPSVPEDK-VQVNLDI---
-AEGKNAPQNPDSTSNSQELTPLCATVF--SKEDPRPWCSSSGMESQETSSESSACGWAI
VKTENQEASSESSSCGWTGVKN--EEDGQA----LESLPLSLQLSLN----------STS
KDLEEMVKMEAEDRVEEMS---STFPE----QDIGEKVKEE--YSMELDRGSPQEK----
PSSARERRREAVVQTEETRAA--SSLSVSQ------EPPDEGSPSGEASRGLP-RDTPSS
VEQET-VLSRPPGKAEDSAIADSQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERS-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMEALQKED-EV----------------------------------------------
-----NDE----------AVGDAAEKPPSTSASPK--TAPEVESSISPAGE-------SI
KAA----GKGRS--NHR-----A-------------RNRRGSRARASKDTSKLLLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQVIYEFESSAQRQTAVDLYKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRRFLRQLEICFAENPSQHQKII
K-VLQGCADCLPQDTTELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPVKVSTASKSKRRKEIGVQNHDKE-TEWPETAKDCSCP
CHEG-GPDSRLKKSKRRNC-HCS-SK------VCDSKCCKSKEPLELVSSSPLQEASSVP
GSKEAGQGKDMLEEEALEEQ-NTAATQIR-TGKATRKGETPIPGST-AGSTLPNSA----
--------------------EVTLM-EQPLEGP-TFCSQETPQLPPQTGVV-LSV-RRNQ
AGPDVS-CLGTST------ILPE------EGEDQKAAANSET-TVSLPDESETETL----
-------------PGTVEL------PASSRT--RDAG-----------------------
--RSY--G----KAGSQSWLLEGRVEAK--TEHTVASVCG------------TSSA---V
TPKAARGA-M----ADDGGTQGRGPE---EAVPKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSIISQRLGNKTPVEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTAT
ESPQHKGNH-EEDDLDLESAV-KPESD--QVKDLNSVSLSWGPSHSRAAGLEIQSLQDAR
NELGMEDLSL---SSR-VPPQDTNVPVLEAVDVTISQGITLSSLEASQPFNICIDKGKLQ
ATGSRRGKKIVLRPGPVTLEDRG----------DHPIIKEPFS--DEPSEEFKEEGGKPQ
MHSG---GELPSLPS--GSFSAQLGSQAMKSSQPSVYASPQEKLPRT-RAHQAEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGP-EEGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEEELTQDDKQKETQIPSAADKDRSGHRRTHSEWTQRADNWGGAGGKAEK
VT-TPTIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCL---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RIPKKE-V----EE-----LFE---------TFQDEKGFSNVEDD--
----GPEEEDRVT---------------ESRPNFN-TPQALRDRFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------ERVKPQTEKVHQTLVLDTAQRKRLQHQMQ-
QHVQLLTQIHLLASSNPSLNSEASTTRIFLKELGTFAQSSIALHQQLNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDW----SPRKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQNKIFFT-KAEDNLLALGLKHFEGTEFPKPLISTYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKYTRCIPLLPVQALC---VNPKPWKKDVFRLSRKV
PSSLQASLPSIQEE-LRNIAVGAREVGNVAGA-TEIKSEPGLEKG----SSEFSSEVQYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSVLKPLLIRP-SPSLQPSS-NSG-------
KTPTRSTQSEAPPSKIMVRIPPLIQPATVLQTVPSVSPLGV----TGGDSFESPV-ALPT
IS--PEARTSCSLS-------ESQALLSPAS---AP----KVMLPS-LAPSKFRKLCVKW
RPPKRKG-AKATPYLKPAPLIH-PAPVIFTVPAATVNVVSLGSSCNMIQPVNATVAQSSQ
AIPITTLLVNPTPFPCPLNQPLVASSIPPLIVSGNSVNLP-VASTPEDK-AHVSVDIACP
LTEGKSDFQGIEPKLEPQEISPLCTAVF--PKEEHSPGLPPADR----------------
---RYQEELSDNSVSGWTTVKT--EEGMQA----L---SLGFQESLNP-------S---P
GDLMQIVKMEPEDSREEIS---SGSPK----QDGGDEVKEE--QSVELDTGSSNEG----
SGGAREVKKQTVLQKEEGRNQPTKTSSASQ------DPPCEGHSGTDVSKGSP-KKASSS
TD-PEKMLSSPLGKPEDASSVDGQSVGTPAGPETGEFSGV-VEKDEILFPNV--------
----VADSPLFSLCSFQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-GI----------------------------------------------
-----TDE----------VVGDPAEKPPSTFTSPQ--TIPEVELNRTPPDVL---QGEGT
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHNPGKYEDFLQVIYEFESSTQKQTAVDLYRSL
RTLLRDWPQLLRDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-AEWPDGAKDCACS
CREG-GPDSKLKKSKRRNCSHCS-SK------VCDSKSCKSKELHELVSSSPHREASPML
GTKEAGQRKDVVEEEASEERENVEATQSR-TGRTTRKGETPVA-GLAEGSPLLSPQ----
--------------------EVTRTDPLLLAGL-PPCSPEAPQLFPQTGAV-LYPVGRNK
AGPEVVSCPRSSP------KLQK------ERDSHKAVVDESETLRLVWSASETEKL----
-------------PGTVEVSASSLSPVSLRT--RDLGRIQV-------------------
--------SAK-PNTEEKWLSSSTEMKKA--NRMSPAYESSSLG-------IDTSE---V
SPKASRGG-----LAKDSGIQGKSPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQELGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDRGDLLSEEELDE

------------------------------------------------MLPCKKRRATVT
ESVHQQDSQ-EGDDLDLESSV-KPESV--QLKDLASESLSWDQHHESAVCPCVASSHDVE
NQLSVEDPSL---RPK-MLTQHGNPPVLEAVDGAIAQEIALPSLESSHSLTVHMDKERLQ
ATASRKGKKIVFPPGLVTREDQG----------DHPVMEEPPS--GEPGEEVMAEGGKLE
MHSGG--E-LPFLSS--GSQSAKPGAQPRKPFQPDGSAFPQEKPLRT-VVHQTEEEKEDG
GLF--IPM-ERQENEESDRRKKTKKGTKRKRDGKCQ-EQGTMAHDLNLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGV-----------------Q-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRA----SSEVAETDEESGMLSEVEK
VT-TPAVRHISAEVVPMGPPPPPKPKQSRDSAFMEKLNAVDEELASSPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKVWLGGLLNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITSKL-VGSLLSF-----PYVFVYSV-DLLQFQDEMGFSNMEED--
----GPEEEERVS---------------ESRPNFN-TPQTL--RFEEPLANLLNERHRTV
KELLEQLKMKKSACKSQP-EV---------ERLKLQKEIVLQTLILDPAQRSRLQQQMQ-
QHVQLLTQVYLLTTSNPNLSSEASTTRVFLKELGTFAENSIALHQQFNPNFQTLFQPCNW
MGAMQLIEDFT-HVS-VDC----SPQKTAKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKIVFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNQNRAPNNVIKVSVCV---------CSSS-P---VPPAEE---HL
A---------------------------LSPP-PLS--CQPFVT------GELSS-----
LCR--MNGLLRS--------------------LPSFLSDL-SFQVSLHL-NPG-------
KMATWPAQSEVPPGNRVVQIPHLIQPTPVLQTLQGFPPVGV----SREDCIESPAAALPA
MPSGPEARTSFPLS-------ESQSLLPS---SSAP----KIMLPS-LAPSSFVCFISKH
C-------------------------LIF-------------------------------
---------------CFLESQ---------------------------------------
----------------------SCSSTE--S-----------KSPKQKVSNLLSSCP---
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------KTVVLETMEKLTWLASERS-MSQEGESEEENSQEENSEPEEEEEEE--
AEGMEALQKEGD-----------V-N-D-E--A-V-G-D-A-A-E-K-Q-PS-T-L-A-S
-P-K-T-A--P-Q-V-E-TS-V-T-P-A-G-E-T---I-K-A-A-G-R-G-R--S-N-H-
R-A-R-N-K-R-G-S-R-A-R-A-S-K--D-T-S-K--L--------------LLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQVIYEFESSTQRHTAVDLYKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPTHHQKII
K-VLQGCADCLPQDISELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRLGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPAKVSTASKSKRRKEIGVQNHDKE-TEWPEVAKDCSCS
CHDG-GPDSKLKKSKRRNC-HCS-SK------VCDSKSYKSKESLELVGNSPLQEASSMT
GNKEVGQDKDVLEEEPLEEQENIAATQSR-SGRTTRKGEIPIPGS-TVGSALPCSA----
--------------------EVTV-VEQPLEGP-TLCSPETPRLPPQTGVV-FSSVRRNQ
VGPEIVSCLGTSTI------LPE------KGEDLKAAANSET-TVPLPDVSETEKL----
-------------PGFVEIPASLPSPVSSRT--SDTGKRHI-------------------
--------CGKAGTQS--WLLESRVEEAK-TIHMMTPICGSSSG-------VDSSE---I
TPQAVRGV-----VPEDRGTQGKGPEG--ALP-KVSEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSIISQQLGNKTPLEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESPQHKSNQ-DEDNIGLESAI-KQESD--LVKDLGSVSLSWGPSHGRVAGFEVQSVQDAG
SQLLMEDVSL---RSG-MLNQDTNVPILDAVDVAVSQGITLSSLESSHLLNIHTGKGKLQ
ATGSRRGKKTALRPGQIAQEDRG----------DHSIIKDPFS--GEPSEE-KEEGGKHQ
MHSG---REMSSVSS--GNQSAKLGTQLRKSSQPDVCASPQEKPLRT-LAHPLEEEVEDG
GLFI--PM-EEQANEENEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGMLSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKIHQTLILDAAQRKRLQQQMQ-
QHVQLLTQIHLLATSNPSLDSEANTTRIFLKELGTFAQSSMALHHQFNPKFQTLFQPCNL
MAAMQLIEDFNTHVS-IDW----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPLCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEVPNPLISKYLLTCKTARQL
--------TVRIKNLNMNRARDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQDE-LRQIADGAREVGNVTGI-SEINSDRGLEKD----SSDLGSETRYP
LLL--PKGVVLKLKPVANHFSRKAWRQKRSSVLKPLPIRP-SPSFQPSF-NPG-------
KMPARSTQSEAPPSKMVVRIPHPIQPATVLQTVPGVPPLGV----NGSDSFESPA-ALPA
LP--SEATTSFLPT-------ESQTLLSSTP---VP----KVILPS-LGPSKFRKPCVKR
RTSKRKR-AKASPCMKLAPLIH-SAPVIFTVPATTVKILSLSSGCNMIQPVSATVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASPISPLIVSGNSVNLP-IPATSEDK-AQVNVDINCP
LAEGKNAFQGLEPKLEPQELPPLCATVF--PKVEPSLGPPPTDK----------------
---ECQERLSDNSAYGWTIVKT--EEGRQA----VEPLPQDFQESLNS--------F--P
GKLEEIVKMEPEDTQEEFG----GSPE----QDICDEVKEE--HSVELDIGSPSEE----
LSSARERKKQTVSPKEEERSQPARAPSASH------EPPDEGNAGGDVSKGSP-KNASSS
TDPPEMVLGTPPGKPEDSSSMDGQSVGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EISSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPSSTFASPE--TAPEVESSRTPPG-------ESI
KTA----GKGRS--NHR-----T-------------RNKRGSRARANKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLVSSRDF--------------------------
---------VFPSVTAQLKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGAQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKNKRRNCSHCS-SK------VCDSKSYKSKEP-ELVGNSPHREASPMP
SAKEARQGQDVME-EAPEERERIEATQSR-TMRTTRKGEMPVPAGLPVGSTLLCPR----
--------------------EVTLTERLLLDGP-PPCSPETPQLPPKVGSA-LYTVRRNQ
AGPEVLSCPQASP------RLQE-------REDQK-AVGEAEPSMLVWDASETEKL----
-------------PGTAELPASFSSPLSSKT--RDVGRRRV-------------------
--------SGK-PDT-ENWLLSGRSGMKTA--GRMSPVCESSSG-------TDTSE---T
SSKAPRGG-----LAKDSGIQGKG-----EQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFGVISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---MENLQKEE-EM----------------------------------------------
-----VDD----------TGGDTSEKPQSTLASPK--TAPEVETCRIPTGE-------SS
KAT----GKGRS--SHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLSRVREALQHIPGKYEDFLQVIYEFESSSQRQTAVDLYKSL
QILLRDWPQLLKDFAAFLLPEQALACGLVSKWAKTAHRA---AECP--------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRATVT
ESVHQQDSQ-EGDDLDLESSV-KPESV--QLKGLASESLSWDQHHESAVCPEVDSSHDVE
NQLSVEDPSL---RPK-MLTQHGNPPVLEAVDGAIAQEIALPSLESSHSLTVHMDKERLQ
ATASRKGKKIVFPPGLVTREDQG----------DHPVMEEPPS--GEPGEEVMAEGGKLE
MHSGG--E-LPFLSS--GSQSAKPGAQPRKPFQPDGSAFPQEKPLRT-VVHQTEEEKEDG
GLF--IPM-ERQENEESDRRKKTKKGTKRKRDGKCQ-EQGTMAHDLNLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGV-----------------Q-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRA----SSEVAETDEESGMLSEVEK
VT-TPAVRHISAEVVPMGPPPPPKPKQSRDSAFMEKLNAVDEELASSPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLE--
LQAPDITVDMYNPT----TANNEDWKLWLGGLLNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITSKL-VGSLLSF-----PYVFVYSV-DLLQFQDEMGFSNMEED--
----GPEEEERVS---------------ESRPNFN-TPQTL--RFEEPLANLLNERHRTV
KELLEQLKMKKSACKSQP-EV---------ERLKLQKEIVLQTLILDPAQRSRLQQQMQ-
QHVQLLTQVYLLTTSNPNLSSEASTTRVFLKELGTFAENSIALHQQFNPNFQTLFQPCNW
MGAMQLIEDFT-HVS-VDC----SPQKTAKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKIVFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNQNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPIEKEEHRL
PFWLKASLQSIQDE-LRNIAEGPAEGENVTPA-PETSTDHPLEKA----SPELGTETRYP
LLM--PKGVVLKLKPGSKRFSRRAWRQKRPLAQKPLLIQP-SPCVQPAL-NPG-------
KMATWPAQSEVPPGNRVVQIPHLIQPTPVLQTLQGFPPVGV----SREDCIESPAAALPA
MPSGPEARTSFPLS-------ESQSLLPS---SSAP----KIMLPS-LAPSKFRKPFSRR
KPTRRKG-AKVSPCVKPAPIV-HPTPVIFAVPATTVKVVSLGSGCNVIQPVNAAVAPNPQ
TIPITTLLVNPTPFPCQLNQPLVASSIPPLIVSGNSLTLP-VPSIPEDN-AHV----NLD
VTEGKSVLQNPDSTLKPQEPTSLCATVF--SKEEPRSWHPSSGTESQEASSELSSCGWTV
VKTENQEASSESSASGWTGVKT--EEDGLA----LGPFPQHLPE----------SLNSTS
KDLEEMVKMEAEDCVGEIP---SSFPE----QVFGDKVKEE--SSVELDSGCHQGT----
LSSSREMRRQAVMQREEPQ--PAKSLPVSQ------DSADEGSTSGDASKGWP-KSTPSC
MEQET-VLSSPPGKPEDSANADGQSVGTPAGPDPGGEKDGPEDEEEEEFDELTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERS-MSQEGESEEENSQEENSEPEEEEEEE--
KESF--------------------------------------------------------
-------------------S-C-V-L-P-G-E-T---I-K-A-A-G-R-G-R--S-N-H-
R-A-R-N-K-R-G-S-R-A-R-A-S-K--D-T-S-K--L--------------LLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQVIYEFESSTQRHTAVDLYKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPTHHQKII
K-VLQGCADCLPQDISELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRLGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPAKVSTASKSKRRKEIGVQNHDKE-TEWPEVAKDCSCS
CHDG-GPDSKLKKSKRRNC-HCS-SK------VCDSKSYKSKESLELVGNSPLQEASSMT
GNKEVGQDKDVLEEEPLEEQENIAATQSR-SGRTTRKGEIPIPGS-TVGSALPCSA----
--------------------EVTV-VEQPLEGP-TLCSPETPRLPPQTGVV-FSSVRRNQ
VGPEIVSCLGTSTI------LPE------KGEDLKAAANSET-TVPLPDVSETEKL----
-------------PGFVEIPASLPSPVSSRT--SDTGKRHI-------------------
--------CGKAGTQS--WLLESRVEEAK-TIHMMTPICGSSSG-------VDSSE---I
TPQAVRGV-----VPEDRGTQGKGPEG--ALP-KVSEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSIISQQLGNKTPLEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ENSQDKSSQ-EEDNLDQESAV-KQESD--QVTDFGSVPLSWGPSHGRAVGVEVHSVQNAG
NQPGVEVPSL---SSR-ILTQDANLPSLEAADEAISQGITLTSLESSHSPNVHIGKGKLQ
ATASKRGKKVVLRPGLVTQEDRG----------DLPVMKKLFS--GDPSEEVKEGG----
------------------------------------------------------------
---------EEQNNEENEKRRKKKKGTKRKRDGRGQ-EQGTLMGDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGVLLEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRAV
KELLEQLKMKKSSAKQQQ-EM---------EKLKPQAEKVHQTLILDVAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTKIFLKELGTFAQSSTALHHQSNPMFQTLFQPCNL
MGAMQLIEDFSTHVS-VDW----SPPKPVRK-----NVYEFSCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKLIFT-KAEDNLLALGLKHFEGTELPKPLISKYLLTCKTAHQL
--------TVRIKNLNQNRAPDNIIKFYKKTKQLPVLLKCCEEVQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LRHIADGAREVGNETVT-TEISTDQGLEKA----RSELGSETRYP
LLL--PKGVVLKLKPVANRFPRKTWRQKRSSV----------------------------
-----------PPNKMVVRIPQLIQPATVLQTVPGVPPLGV----SGEDSFESPA-PLSA
VP--PEVRTSFPLS-------ESQTILSSAP---VP----KVMLPS-LGPSRFRKPCVRR
KPSRKKG-AKTFPCPKPAPLIH-SAPVIFTVPATTVKVVSLGSGCNVIQPVNAAVAPSPQ
TIPITTLLVNPTSFSCPLSQPLVASSIPPLIVSSNAVNLS-VSSTPEDK-AQVNVDIGCP
LAEGKNAFQSLEPKLEPQEITPLCVPVF--PKEEHSPRSLAASR----------------
---ENQVGLSENSGCGRMIVET--EEGRQG----LEPLPQGFQGFLKS-------S---S
GDLKEVVKMEPEDPGEVIS---SGSPE----QHICDEIKKE--WFVERDTGSPREE----
LSSARALKKQSILQKE-ERSQPTHTSAASQ------ESPAEGNAVGDVSKDSP-RNALSS
VE-PEMVLSSPLGKAEEASSVDGQSVGTPAGPDVGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----TDD----------PVADTAEKLASPLVSPK--AAPEVESCRISPG-------ESI
KAT----GKSRN--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVLYEFESSSQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCIPHEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEVGVQNHDKD-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCS-GS-----KVCDSKPYKHKEPQESVSSSPHGEASPVL
GTKEAGQGKELVEEEALEERESTEALQK--TSRTTQKEEMPVP-GTTVQSMLPSPQ----
--------------------EVPLTERLLEGA--PSPTPETPQHPAPTAAV-PHTVQRSQ
AGPEVLSTSAS--L-----GHEK------ERNGYK-AVGDSEASLLVWDVSQPETS----
-------------HGTVEPSAPFLSPASSRT--KGVGRRHV-------------------
--------SRN-PDTQDTWLSSSRAGTRRA--NRLSPGYEPSVG-------INTSE---T
SPQVPKGS-----LTKDSGVQVRGPD--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSSISQQLGNKTPAEVSH-RFGELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESSQDQGNQ-EEEDLDLESAI-KPSSD--QVKDLGSASLSGGPSHGRVAGLQVESLQDAS
NQLCVEDPSLSSLSSR-ILTQDTSAPVLEAVDAAISQGITLPSLESSQLLHAHVGKGKVQ
APGARRGKKIMLRPGPVSQENRG----------DHPITKEPFS--GEPGEEVKEEGGKPQ
LHSG---GAMPLLPL--GSHSAKPGAQPGKSPQPDVCACPQEKPLGT-LASQAEDETEDG
GLFI--PM-EEQSGEESERRRRKRKGSKRKRDARGP-EGGTCTCDLKLDDAL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEEGSMLSEAEK
VP-APAVRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPICM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGLSNVEDD--
----GPEEEERVA---------------EPRPSFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLKMKKSSGRQQQ-EV---------EKVKPQSEKVHQTLTLDPAQRGRLQQQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTRIFLKELGTFAQSSVALHHQSSPGFQTLFQPCNL
LGAMQLIEDFNTHISVIDW----SPRKTVKK-----TADEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTKFPKLLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLMKCCEEIQPHQWKPPVEREEHRL
PFWLQASLPSIQEE-LWRIAGGARGVGNVTGA-AEVSSEPCLGKG----RSELGSDTPYP
LLL--PKGVVLKLKPVANCFSRKAWRQKRPAVLKPLLIRP-SPSLQPSSSTSG-------
KAPTRSAQSEAPPSKMVVRIPPMIQPATVLQTVPGVPPLGA----PAGDGFESPA-TLPP
TP--HEARTSFPLS-------EPQPLLTPAP---VP----KVMLPS-LAPSKFRRPCVKP
RASKRKG-AKASLCLEPTSLIH-PVPVIFTVPATTVKVVSFGSGCNVIQPVNAAVAPSSQ
TIPITTLLVNPTSFPCPLNQPLVASSLPPFIVSSNSVSLP-VPSTPEDK-AQVNADIGGP
LAEGKNAFQGLEPKLEPQEFSPLCAPVF--PKEEHSPGPLAADC----------------
---VCQEELPENSACGWTLVKA--EDERQA----LQPLP--------------------P
GDVEEMVKMEPKDPGEDDA---SGSPG----QDGCEDIREE--CAVGLDAGFPGEE----
LSSPRERRGQPAVQQEEERSEPAGASSAAR------EPRDEGDSG-DMSKGSL-EMASSC
AD-HEVTCGSPLGQSEACGSTDGQVVETPAGP---------EEEEEEDFDDLTADEE--E
ELSSASEESVLSVPELQETMEKLTWLASERR-AGQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----ADE----------AIGDPTEKPPAPFASPR--TAPEAEASSTPPG-------ESG
RAA----GKGRG--SQR-----A-------------RGKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QVLLQDWPQLLKDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPS HHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKSKRRKEIGVQNHDKE-AEWPDSAKDCACS
CHEG-GPDSRLKKSKRRSCSHCG-SR------VCDSKSYKSKEPHELVGSSPHREASPGP
GAKEVGQGKDLLEGETPEDREGKETSQDR-PGRGAGQGETPVP-GLAMGSTSLSPQ----
--------------------EVTSIAQPALAGP-LPCSPESVKLSSSTESV-LCTVRRNQ
AGPEVLSCPQASP------RLQN------EGKEQE-ALGEPQASMPTWDASETERW----
-------------PSTAEPCAPFLSPVSSRT--RDSGRSLV-------------------
--------PEI-SDAPESCLLLGRPGVRTA-NRRSPVCES-SSG-------IDTSA---T
SCKASRGS-----SAKDGEIQGKGPV--GEQPLKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEKGAQPQTFSSISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEEEDDA
TSTSNTDQLSDRGDLLSEEELDG

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------KLPP
MLSGG--E-LPSLPE--ASQSTKPGSQPWELSPLAVGVSPQDQLLRA-PATHAEDETEDG
GLFIPTXX-XXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXX----------
-----XXXXXXXXXXXXXXXXXXXXXXXXXEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVXXXXXXXXXXX-XXXXXX-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESSASLPRGAKKSRLRQ----SSEMTETDEESSMLSEAEK
VTSVPAVRHISAEVVPMGPPPPPKPRQTRDSTFMEKLHAVDEELASGPVCM---------
---------------ESFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPH----TADDEDWKNWLGGLMNDDVGNEXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXX-XXXXKE-VNELMEE-----LF---------ETFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXX----XXXXXXXX-----XXSEFPCLPKQVAWILATNKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXFYKKTKQLPILVKCCEEIQPHQWKPPIEREEHRL
PFWLKVLQPLPA------------------------------------------------
------------------------------------------------------------
-----------------------------------GPPLGL----S------QPLKTLP-
-AVSPEARGSFPPS-------EPQPLLPA---APLP----KVLLPS-LAPSKFRKPSVKR
RGARRKG-AKASVCLKAAPLI-HTAPVIFTVPATTVKVVSLGSGCNVLQPVSAAVAQSSP
PIPITTLLVNPASFPCPLSQPLVASSIPPLIVSGNSVNLP-VASNPEEK-VPMPMDTSCP
MAEGKSAFPGLQPKQEPSEQVLTGGPVL--HKEEQSPVPAPVASVCRA------------
-------DPAESSTYGWTVVKT--EAGRPA----LEPRAEAFLE----------DTPP--
RGVDITVKVEPKDPGEEPS---GGLQE----PDAGGEIKEE--HPMELDAGFPHGQ----
AGEKE-----------GDQ--PA-----------------GEATPGEVSRASPGSATASC
ADVDG-ALTNSAGGPEDVSNIYGHSRGTPASTGVQGGTGGRGDKL----DRSTPXXX--X
XXXXXXXXXXXXXXXXXETMEKLTWLASERR-MSQDGESEEENSQEENSEPEEEDEEE--
AEGLESREGDADDA----------------------------------------------
-------------------LGCPAVTPPAPFASPP--LPPEAQRSGTPPG-------EHI
KESGK----GRN--KHR-----ARS-------------RRVSRARASKDTAKLLLLFDED
ILERDPLREQKDLAFAQAYLARVREALQHVPGKYEDFLQVIYEFESSAQKQTAVDLYKSL
QTLLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQSCADCLPREIMEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXE-AEWPDGAKDCICP
CHEG-GPDSKLKKSKRRNCSHCS-SK------ACDSKPYKSKEPPEVVGSSPHREPS---
-PKEIGVGKDALEED-------PEATPSR-TGRTNRKGDLPVAXXXXXXXXXXXXX----
--------------------XXXX-XXXXXXXX-XXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXX------XXX------XXXXXXXXXXXXXXXXXXXXXXXXXXX----
-------------XXXXXXXXXXXXXXXXXX--XXXXXXXX-------------------
--------XXXXXXXX--XXXXXXXXXXX-XXXXXXXXXXXXXX-------XXXXX---X
XXXXXSGG-----LTKDGGTPGRSPEG--EQLPKAAEATVCANNSKVSSTGEKVVLWTRE
ADRVILTVCQEQGAQPQTFNAISQQLGNKTPAEVSL-RFRELMQLFHTACEASSEDDDDA
TSTSNTDQLSDHGDLLSEEEPDE

------------------------------------------------MLPCRKRRTTVT
RSPQHKGNQ-EEDNIGLEAAV-KQESD--QVKDLGSVSLSWDPSHGRVTGFEVQSVQDAG
NQLGMEDTSL---NPR-MLMQDTSVPILEAVDVAISQGLTLPSLESSSPLNVHIGKGKLQ
ATGSRRGKKIALRPGLVSQEDRG----------DHPIIKEPFS--GEPIEEVKEEGGKPQ
MHTG---GEIPSLSS--GSQSSKPGTQPRKSSQPDICASPQEKPLRT-LAHQPEEEIEDG
GLFI--PM-EDQDNEESEKRRKKKKGTKRKRDGRGQ--ERTLGYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMF-----
--------------------VIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAVRHISAEVVPMGPPPPPKPKQTKDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ETRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKLKKSSAKQQQ-EV---------EKVKPRSEKVQQTLILDVAQRKRLQQQMQ-
QHVQLLTQIHLLATYNPNLTSETSTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
IGAMQLIEDFNTHVS-IDW----SPHKTVKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTEFRNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAHDNIIKFYKKTKQLPILVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LRHIADGAREVGNVTGT-TEINSDRGLEKD----ISELRSETQYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSVLKPLLIRP-NPSLQPSF-NPG-------
KTPARSTESEAPPSKMVVQIPHLIQPATVLQTVPGVPPLGI----NGGDSFESPA-ALPA
ML--PEARTSFPLS-------ESQTLLSSVP---VP----KVMLPS-LAPSKFRKPCVRR
RPSKRKG-AKASPCMKPAPVIH-SAPVIFTVPATTVKIVSLGTGCNVIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLMASSISPLIVSGNSVNLP-IPSTTEDK-AQVNVDIACS
LAEGRNAFQALEPKLEPQELSPLCATVF--PKEEHSPGPPPVDR----------------
---ECQEGLSENSAYHWTIVKT--EEGKQA----LELLPPSFQKSLNS-------PSGRG
RNLEEIVKMEPEDAGEEIS----GSPE----QDICREIKEE--HSMDLETGSPSEE----
LSSAREVKKQTVLQKEDEKSQAAKTPAASQ------EPPDEGNSGGDVSKGSP-KNVSSS
TD-PEVMLSSPPGKPEDSSSVDGQSVGTPAGPEVGGEKDGPDEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
TEGMESLQKED-EM----------------------------------------------
-----TDE----------TVGDSAERPPSTSASPK--TAPEVETSRTPPG-------ESM
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQSYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADFLPQEISELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKNKRRNCSHCN-SK------VYDSKPYKSKEPHELVGSSPHREASPMP
GAKDAGQGKDMMEEEAPEERENIEATQSK-SGRTTRKGEMPVPAGLPVGSTLLSPQ----
--------------------EV-LTEQLLLDGP-PPRSPETPQFPPKSGAV-PYTVKRHQ
AGPDVLSCPKASL------RRQK------DREGQK-TVGESEALMLVWDVSKTEKL----
-------------PGTVEPSASFLSPVSSRT--RDLERRHI-------------------
--------SGK-LDTQESWLPSNRAGMKTA--DGISPVDESSSG-------IDNSE---T
SPKAPGGG-----LAKDSGIQGKGSE--GEQQPKTTEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSVISQQLGNKSPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSSVSLSWDPSHGRVAGFEVQSLQDAG
NQLGMEDTSL---SSG-MLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLH
ATGSKRGKKMTLRPGPVTQEDRC----------DHLTLKEPFS--GEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEECVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNMTGT-TEINSDRSLEKD----NLELGSESRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
VP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VADGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEEAREEIS----GSPE----RDICDDIKVE--HAVELDTGAPSEE----
LSSAGEVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPP-TFASPE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GAKEAGQGKDMMEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGSTLPSPR----
--------------------EVTVTERLLLDGP-PPHSPETPQFPPTTGAV-LYTVKRNQ
VGPEVRSCPKASP------RLQK------EREGQK-AVSESEALMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTCPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQAKGPE--GEQQPKAAEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFNIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEETEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NSELEGETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEGRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-IKASRCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPPADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--S
GDLEEVVKMEPEDATEEIS----GSPE----RDICDDIKEE--HAVELDTGVASEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSE------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-ET----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------DSI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAE-----------LFHTACEASSEDEDDA
TSTSNADQLSDRGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KAESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GELPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQNEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADSAREVGHVTGT-TEINSDHGLEKD----NSELESETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLAV----SGGESFESPA-ALPA
MP--PEGRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-IKASPCMKPTPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLMASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPSADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESVNN-------SS--S
GDLEEVVKVEPEDAREEIS----GSPE----RDICDDIKEE--HAVELDTGVTSED----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEESPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAE-----------LFHTACEASSEDEDDA
TSTSNADQLSDRGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSSVSLSWDPSHGRVAGFEVQSLQDAG
NQLGMEDTSL---SSG-MLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLH
ATGSKRGKKMTLRPGPVTQEDRC----------DHLTLKEPFS--GEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLTT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VS-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNVTGT-TEINSDRSLEKD----NLELGSETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMMLRIPHPIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VADGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEEAREEIS----GSPE----RDICDDIKVE--HAVELDTGAPSEE----
LSSAGEVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTFASPE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GAKEAGQGKDMMEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPTTGAV-LYTVKRNQ
VGPEVRSCPKASP------RLQK------EREGQK-AVK------IAWYR----------
-----------------GTPCFLLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTCPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQAKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSTISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTMT
ESLQHESNQ-EEDDLDLESTV-KPESD--QVRDLGS--LSWGSSHDSAVGFEVQSVQDAG
DQLGVEDPSL---TPRMMLTQHTNLPVLDSVDAAVSQGISLSSVESSNPLNVQISKGKQQ
ATASRRGKKIALRPGPVTQEDRE-----------------PFP--EEPSEEVKEERGKPQ
MHSGG--EEIPLLPS--GSQSADPGAQPRKSSQPDVCASPQEEPLRS-LAHQAEEEREDG
GLF--IPM-EEQDSKESEKRRRMKKGTKRKRDGRSQ-EQGTMAYDLKLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEDEDETAEESLLESDVESTASSPRGAKKSKLKQ----SSEMTETDEESGLSSEVTT
PR----PR---------VQAPRPDPKKK--------------------------------
---------------KRENSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLINDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFET---------FQDEMGFSNKEED--
----GPEEEERVT---------------ETRPNFN-TPQAL--RFEEPLSNLLNEQHRTV
KELLEQLKMKKSSAKQHP-EA---------ERLKPQSEKVHQTLTLDPAQRKRLQQQMQ-
QHVQLLTQIHLLAISNPNLSSEASTTRMFLKELGTFAENSITLQQQFNPKFQTLFQPCNL
MGAMQLIEDFNTHVH-IDW----SPRKTVKK-----TAGEFPCLPKQVAWILATSKVFMY
PEL-LPICSLKASNPQDKIIFT-KAEDNYTKIFQF-------HNQVMSTMLLDQCHHHPL
----------------HCSPPFIHAQFYKKTKQLPILVRCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-MKNITNGATEEGNVTRT-TEVNEKKDQEKA----RPELGNETRYP
LLL--PKDVVLKLKPVSKRFSRKAWRQKRSSVLKPLLIQP-SPSVLPSF-NPG-------
KIAAWPTQSEVPPSKMVVQIPHLIQPATVLQTVPGFPSLGDP---QGKDNFEPTT-ALPA
VPA--EARTSIPFP-------ESHTLLPSAP---VP----KMLLPS-LAPSKFRKPCVRR
KPSRRKG-AKASPCVKPAPLM-HPTPVIFTVPAATVKVVSLGSGCNMIQPVNAAVAPNPQ
TIPITTLLVNPAPFPCPLNQPLVASSISPLIVSGNSVNLP-IPSTLKDK-TQVNADIACP
LVEGKNASQSLEPKLEPQELTPLCATVF--PKEEHSPGPPSADRECQEGLSERPACGVTV
VKSEIQEGLSEKSACGWAIVKT--EEGRQT----LETLPQGFQESLC----------SSH
GDLEEIVKLEPEDPVEEIS---SGFPE----QEICDEIKNE--HSIELSTDSLREE----
LSSARDVKKQMILT--------------------------------------L-KNVPSS
IDPEI-ELNSPPRKSEDTSSVDGQSLGIPLVPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
VEGMENHQKED-EM----------------------------------------------
-----TDE----------AVGDAVEKPPSTLASPK--TTPQVETSRTPPGG-------SI
KAA----GKGRN--SHR-----V-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESNTQRQTAVDLYKSL
QILLQEWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPTASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPSTSKNKRRKEIGIQNHDKPLAPCLKVLRGGFCG
KHES-------------RQ-RVS-LQ------VCENKSYKNKEPHELVGSSPHGAASPMS
GVKEAGPGKDVVEEEVPEERESIESTQSR-TSRTMRKGEVPIPPGSTVGNTLLPLQ----
--------------------EETLT-EQLLAGP-APHLPDTLQLCSQTGAV-SPTV-RNQ
AGAEALSCPRVSL-------SPQ------KEEGQQAAADSEV-PMLVSGAPETEKL----
-------------PCTNEGPASFFSPDSSRT--REVQ-----------------------
--KIH--VSGK-PGNHENWLPSSRVGTK--TADKMSSVHE-S------SSGVDISE---T
SPKAFRGD-L----VKDSGIQGKGPEQQGELQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEEPDD

------------------------------------------------MLPCKKRRISVT
ESSQQQDDQ-EGDDLGLEAAV-KPDTD--QLPDSASESLSWGQSQDSAVCPEGHSMQDGD
DQLRAEGLSL---NSK-KLAQHVNLAVLEAVDVAVSQEIPLPSLESSHSLPVHMDKGRLQ
VSASRKGKRIVFTPGQVTREDRG----------DHPVPEEPPS--GEPAEEAKTEGE---
------------------------------------------------------------
-----------QDSEESDKKKKTKKGTKRKRDGKGP-EQGTMVYDPKLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGV-----------------Q-PPQFVDIHLE--EDDSSDEEY
SPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRL----SSEVAETDEESGMLSEVEK
AA-TPALRHISAEVVPMGPPPPPKPKQSRDSAFMEKLDAVDEELASSPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKQWLGGLINDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFETVQSV-VPIKFQDEMGFSNMEDD--
----GPEEEERAT---------------ESRPSFN-TPQAL--RFEEPLANLLNERHRTV
KELLEQLKMKKPSVRQQP-EV---------EKLKPQEEAAHQTLVLDPAQRSRLQQQMQ-
QHVQLLTQIYLLTTSNPNLSSEASTTRVFLKELGTFAENSIALHQQFNPRFQTLFQPCNW
MGAMRLIEDFT-QVS-IDC----SPHKTAKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKTIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRL
PFWLKASLQSIQDE-LRNISEGATEGGSVTTA-TESSTDQHLQKA----SPALGDEPQYP
LLL--PKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQP-SPSVQPVF-NPG-------
KMATWPSQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGV----RGEDGFESPT-ALPA
MPCGSEARTSFPLS-------ETQSAPPS---CPAP----KLMLPS-LAPSEFRKPYVRR
KPTRRKG-AKASPCVKPAPVI-HPTPVIFTVPATTVQVVSLGGGCNMIQPVSAAVAPSPQ
TIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLP-VTSIPEDK-AQV----KLD
VAEGKNAPQNPESKLKPQELTPLCTTVF--SKEEPKSWHSSADTGSQEAFSESSACSWAV
VKTESQEGSSEMSACGWTVVKT--EDGGHA----VEPLPQNLQD----------SLSSPS
KDLLNMVKMEAEDCMVEIS---SKFPK----QDIGEEVKEE--CSMELDSDSPQEK----
PSSASEMRKQTVLQREDTQ--AAKSPSVSQ------DAAAEGRTSSHASRGLP-KSTPSS
MGQGG-GLSGPPGKLEDSANAEGQSVGTPAGPDTGGEKDGPEEEEEEDLDDLTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERQ-MSQEGESXXXXXXXXXXXXXXXXXXX--
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXRFLLTLQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPAKVSTASKSKRRKEIGVQHQDKD-TEWPEAAKDCSCS
CHEG-GPESKLKKSKRRNC-HCS-SK------VCDSKPYKSKEPPELVGSGPLHEASTVP
GSKEAGQGKDMLEEEIPEEQENMEVTQSK-TGRTTRKGEAPTPGS-TVGSTLLCPA----
--------------------EVTP-MELLLEGP-ALCSAETPRLPPQTGAV-VCSVRRNQ
AGPEVVSCLSTSSL------PPE------EGEDQRAAANSET-IAPHREASETERL----
-------------PETVEPPAPLPSPVSTRT--RDTGRRHI-------------------
--------CGKAGSQS--WLIESRAE-AE-AAHVVAPICEKSSG-------ARASE---A
APKTAREV-----LAEDSGTQGMGPEG--ALP-KASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSSVSLSWDPSHGRVAGFEVQPLQDAG
NQLGMEDTSL---SSG-MLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLH
ATGSKRGKKMTLRPGPVTQEDRC----------DHLTLKEPFS--GEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VS-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNVTGT-TEINSDRSLEKD----NLELGSETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMMLRIPHPIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VADGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEEAREEIS----GSPE----RDICDDIKVE--HAVELDTGAPSEE----
LSSAGEVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTFASPE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GAKEAGQGKDMMEEEAPEERESTEATQSR-TVRTTRKGEMPVS-GLAVGGTLSSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPTTGAV-LYTVKRNQ
VGPEVRSCPKASP------RLQK------EREGQK-AVSESEALMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTCPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQAKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRSQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NSELESETQYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEGRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPSADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--P
GDLEEVVKVEPEDAREEIS----GSPE----RDICDDIKEE--HAVELDTGVTSEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPAGKPEESPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEALSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSLPPFSRIMQLFHSACEATMMQPV--
--PAMADQLSDRVDLLSEE----

------------------------------------------------MLPCKKRRTTVT
ESMQQKEGQ-EGDGLDLDTAD--------QVKDSG--SVSWYQSNDSAVCPEVHSLQDAE
NQLSMEDPSS---SSK-MLTQHTNFPVLEAVDVAISQGITLPSLESSPSLNMNIGKGRLQ
ATASQRGKKIVLKPGPVTKEDRS----------DHPVIEEPSS--GGLSEEVKREGGKPH
MHSG---EELPLLSS--GSQSAKPGTQPRKPSQPGVSAFPQEKPLRN-LVHQAEEEIEDG
GLFI--PM--DQDSEESEKKKKNKKGTKRKRDGQGQ-EQGTLADDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANELK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEEETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMAETDEESGVLSEAEK
VT-MPALRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQTME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKVWLGGLVNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFE---------TFQDELGFSNMEDD--
----GPEEEERVT---------------ESRPNFN-TPQAL--RFEEPLANLLNERHRTV
KELLEQLKMKKSSVKQQP-EL---------ERQNPPKEKVHQTLILDPAQRNRLQQQMR-
QHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGIFAENSMAVHQQFNPRFQTLFQPCNW
MGAMQLIEDFNTHVS-SDC----SPHKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNLNRAPNNIIKFYKKTKQLPVLLRCCEEIQPHQWKPPVEREEHRL
PFWLKASLQSIQDE-LRSIADSAREGANVTAA-TETGTDQHSEKA----NPELGSQTQYP
LLL--PKGVVLKLKPSSKRFSRKAWRQKRPSVQKPLLIQP-SPSLQP----IG-------
KIPTWTTQPEVPQSNMVVQIPHLIQPTTVLQTVPGFPPVGV----SREDSFESPA-VRPA
MSSGSEARTSFPLS-------ELQSPLPSAS---VP----KLMLPS-LGPSKFRKPYVRR
KPSRRKG-AKVSPCMKPAPILH-PTPVIFTVPATTVKVVSLGSGCNMIQPVTATVAPNPQ
TIPITTLLVNPTSFPCPLNQPLVASSISPLIVSGSPLTLP-VPSTPEDK-AQVNMDIS--
--EGKNASQNSESKLRESQEGL----------SKSACGWTIVKT----------------
---ESQEGLSERSTCDWARVKT--EEGRQA----LEPLPQGFQESINT-------D---P
RNLEEIVKMEPEDCVEEVS---SSFPE----QNVCDAIKEE--HAMEVNSGPLQER----
LSSAREVEKQTAVRKE---SQLAESPAASR------EPPDEGSTSGDVSKGLP-KSTPPS
MD-LDVVLSSPPGKPEDSASADGQSMGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
TEGMENLQKQD-EV----------------------------------------------
-----NDE----------AVGGAVEKPPSTLASPQ--TAPEVEPSITLPG-------QSM
KAA----GKGRS--NHR-----T-------------RNKRGSRARASKDTSKLLLLYDED
ILNRDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQIIYEFESSSQRQTAVDLYRSL
QILLRDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQGEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPAKIATAPKSKKRKEIGVQNHDKE-TEWPEGAKDCSCS
CHEG-GPDSKLKKTKKRNC-HCS-SK------ACDSKSYKSKEPHELVGSSPHQDTSPMP
GTKEAGQGKDTVEEEVLDERENIEPTQNR-TGRTTRKGEIPTL-GSAFGNTLQSSP----
--------------------EVTPMEQPSE--GILLGSPEIPQLPLQTGAV-LST-VRNK
AGPEVLSYHSAFP------IFPK------EGEGQK-AVGDSNTSVPLPGTSVTEKL----
-------------PGTVGLPASSPSPVSSRT--RDIGRRQL-------------------
--------SGK-PDLQRSWLPSGRAEAERA--NTVSPVCEISSN-------IGASE---P
APIAAKGD-----LAKDSRLQSKGSE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPIEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------------------------------------
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------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------MSQEGESEEENSQEENSEPEEEEEE--E
AEGIENLQKED-EM----------------------------------------------
-----IDG----------AAGDTAAKPPSSLATPS--TAAEVESSRAPPGE-------ST
KAS----GKGRS--SYR-----A-------------RNKRGSRARASKDASKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQVIYEFESSTQRQTAMELYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLVKLM-PLYPHKAKLDGC---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRTTVA
ESPQHKGSQ-EEDDVDLESAV-KPESD--QVKDLGSVSLSWGQSHDRAASLEVQSVQDAG
NQLGVEEPSS---SSR-MPTQDTSLSILEAVDEPFSQGITLPSLESSQPLNIHIGKGKLQ
ATGSRRGKKITLRPGLVTQEERG----------DHPSTQEPFS--GEPSEEVKEEGGKPQ
MHSG---GEIPSLPL--GSHLAKPGTQPRKSSQPGVCASSQEKPPRT-LAHQAEEEMEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ-EEGTLTYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
HPDDDEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEEGGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCV---------
---------------DSFQTMD---------DSLIAFRTRSKMPLKDVPL----GQLEAK
LRAPDITPDMYDPN----TADDENWKMWLGGLMNDDVGNEDEGDDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFPKVEDD--
----GPEEKDRVA---------------ESRPNFN-TPQVL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSSRQQQ-EA---------ERVKPKSEKVPQTLVLDLAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPSLSSEASTTRVFLKELGTVAQSSITLHHQFNPESQPLFQPCNL
MGAMQLIEDFSTHVS-IDW----SPRKTSKK-----PAYEFPCLPKQVAWILATSKVFMY
PEL-LPLCSLQAKDPEDKSFFT-KAEDNLLALGLKHFECTEFPKPLISKYLLTCKTVHQL
--------TVRIKSLNLRRAPDNIVKLYKKTKQLPVLVKCCEEVQPHQWKPPVEREEHRL
PFWLKASLPSIQKE-LRHMADGAGEVGNVTGA-PETNSDPGRNKG----SSELGSEARYP
LLL--PKGVVLKLKPVAKRFSRKAWRQKRSSGLKPLLIRP-SPSLQPSF-NSG-------
KTPARSTQSETPPSKMVGQIPHPI------QTVPGIPPLEV----TGGHGFESSL-ALP-
-----EARTSFP--------------LTSAP---VP----KVMLPS-LAPSKFRKPCVKR
RPPKRKG-AKTSPCLKPAPFIH-PAPVIFTVPATTVKVVSLSTGCNVIQPVNAAVAQSSQ
TIPIATLLVNPTSFPCPLNQPLVTSSIPPLIVSGNSMNLH-VPSTPEDK-AQGNVDIACP
LAEGKGAVQGLEPKVEPQEPSPLGTTVL--PKEEQSPGPLQADG----------------
---GCQEELSENCTYHWTIVKT--EEGGKA----LEALPQSLPESLNT-------P---P
GNLEEIVKIEPEEPREEIS---SRSPE----QDICGEVKDE--PSVELDTSSPCEG----
SSGTRDVRKHTVLQKEEEKSHLTKTLSGSQ------EPSEEGNSGGDVSKGSP-KTPVSS
TD-PEMVLSSPLGKPEDSSSVDGQSVGDSSWARNWKERRMGHRREEEDFDDLXXXXX--X
XXXXXXSHYSQSLGAFQETMEKLTWLASERR-LSQEGESEEENSQEENSEQEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDPTEKPPSTFTSPK--TAPEVETSRTPPG-------ENI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
RTLLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPTASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGTKDCACS
CHDG-GPDSKLKKSKRRHCSHCS-SK------VCDSKS-KSKEPHELVSSSPHREASPMP
GAKDTGQGKDAVEEETPEERESIEATQSR-TGRVTRKGETPVPAGLAVESTLLSPQ----
--------------------EVTLTDRLLLDGP-PPCSPETPQLSPQ-------TVKRNQ
VGLEVASYTKAPPE-----ELHK------EREGHK-AVGESETSRLVWDASETETF----
-------------PGTAELPASSLSPVSSRT--RDLGRRQV-------------------
--------SGK-PDTQESWLPSSRAGMKTA-DRMSPVHESSSSG-------VDASE---N
SPKTLGGS-----LAKDSGMQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEEEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSSVSLSWDPSHGRVAGFEVQSLQDAG
NQLGMEDTSL---SSG-MLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLH
ATGSKRGKKMTLRPGPVTQEDRC----------DHLTLKEPFS--GEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEATTTRIFL------------------------------
--------------------------------------NEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNVTGT-TEINSDRSLEKD----NLELGSETRYP
LLL--PKGIVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGV----SGGESFETPA-ALPA
MP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VADGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEEAREEIS----GSPE----RDICDDIKVE--HAVELDTGAPSEE----
LSSAREVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPLSTFASPE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDNKSYKSKEPHELVGSSPHREASPMP
GAKEAGQGKDMMEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTLTERRLLDGP-PPRSPETPQFPPTTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVSESEALMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSR------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLSSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGLEDTSL---SSG-MLTQNTNVPILEGVDVAISQGITLTSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHLILKEPFS--GEPSEEVKEEGGKPQ
MNSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCAPPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLTYDVKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLVEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRRMADGAREVGNVTGT-TEINSDQGLEKD----NLELESETRYP
LLL--PKGIVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLQIPHPIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLP-VPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLCATVF--PKVEHSPGPPLADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------PT--P
GDLEEIVKMEPEDAREEIS----GSPE----CDICDDIKVE--HAVELDTGTPSEE----
LSSAREVTKQTVLQKEEERSQPTKTPSSSQ------EPPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTFALPE--TTPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSRCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GAKEAGQGKDVMEEEVPEERESTEATQSR-TVRTTRKGEIPVSAGSAVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASL------RLQK------EREGQK-AVSESEALMLVWDASETEKL----
-------------TGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQDRWLPSSRARVKT--RDRTCPVRESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTEGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSSISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ENSQDKSSQ-EEDNLDQESAV-KPESD--LLKDLGSVSLSWGPSHGRTVGFEVQSVQNVG
NQPGVEAPLL---SSR-ILTQDTNLPSLEAVDEAISQEITLTSLESSHSPNVHIGKGKLQ
ATASKRGKKVVIRPGLVTQEDRG----------DLPIMKKPFA--GEPGEEVKEEGGEM-
-TEP---GVVPLLPS--DSQSVKPGAQPRKSSLPDVCASPQEKPLRT-LAQQAEEEREDG
G-----PY-SHRYSEENEKRRKKKKGTKRKRDGRGQ-EQGALACDLKLDDVL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPGEEDEDETAEESLLESDVESTASSPRGAKKSRLKQ----SSEIAETDEESGVLLEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPLD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRAV
KELLEQLKMKKSSARQQQ-EV---------EKLKPQAEKVHQTLILDEVQRKRLQEQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTKIFLKELGTFAQSSTALHHQSNPTFQTLFQPCNL
MGAMQLIEDFSTHVS-VDW----IPPKTMRK-----NGHEFFCLPKQVAWILATSKVFMY
PEL-LPLCSLKAKNPQDKLIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNLSRAPDNVVKFYKKTKQLPVLSKCCEEVQPHERKPPLEREEHRL
PFWLKASLPSIQEE-LRLGAHDGRAVGNGTGT-TEVSADRGLEKA----RSEPGSETRYP
LLL--PKGVVLKLKPVANRFSRKTWRQKRSSV----------------------------
-----------PPSKMVVRVPQLIQPAAVLQPAPGVPPLGL----SGDNSFESPA-ALST
VP--PEARTSFLLS-------ESQALPPSAP---VP----KVMLPS-LGP-RFRKPCVRR
KPSRRKG-AKVFPCPKPAPLIH-SAPVIFTVPATTVKVVSLGSGCNVIQPVSAAVARSPQ
TIPITTLLVNPASFPCPLSQPLVASSISPLIVSGNSVNLP-VSSTPEDK-ARVNVDISCP
LAEGKNAFQSLEPKLEPQEVTPLCAPVF--PKEEYGPRPLLAGREG--------------
--REGQVGLSANSACGWTVVSK--EEGRQG----LEPLPQGFHGIRNS-------S---P
ADLKEAVKMEPEDPGEAIS---SGPPE----QRIGDEIKKE--RFVEWDSGSPREG----
LSSARVLKKQAVLQEEEDRSQPAQTPSASW------EPPGEGSAVGDGS------SAPSS
VE-PEMALSSAPGKPEEASGVGGPSAGGPAGPEVGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----VDD----------TGGDTAEKPPSTLASPT--TAPEVETCRIPAG-------ENI
KAA----GKGRS--SHR-----A-------------RTKRGSRARASKDASKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSSQRQTAVDLYKSL
QILLRDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCVPHEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEISWTE
EKEYEFDGFEEVALPDVEEEEEAPKIPTASKNKRRKEAGAQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCS-GT-----KVCDSKPYKHKEPPESVSSSPHGEASPGR
SAKEAGPGKELGEEEALEDPESTDAPQSR-AGRAARKGEAPIP-GSAVRSLLLSPQ----
--------------------EVPLTDHLPEGP--PAP-PETPQCPPPTAAE-LDAVQRSQ
AGPEGPSASAC--A-----R-PE------EGASRK-AAGDSEAASRGWDALQPEPL----
-------------LGTVETPAPSLSPASSRT--RVIGRRLT-------------------
--------PGK-PDPQDSWLPSSRAGARRA--NRTSPGHEPSTG-------MDTSE---T
APEAPKRS-----LAKDGGVQGRGLE--GEQQLKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSSISRQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MVPCKRRRAAVT
ESVQQP------DDLDLESAA-KPEPG--RLKDLGSESPSWGQRQESSGCPEVHSVHDGE
SQLSMEDPSL---SSK-MLTQRGNLPVLEAVDVAISQEITLPSVESSHSLTVHLDKGRLQ
ATASRKAKKIVFQPGQVTREDRG----------DHPVIEEPPLLEGEPGGEVKAEGGKGE
RSRLLFPCPLRLSQS--ESQSAKR-------------PMEQQKALNA-FLEKLFWRV-CD
VLVS--FS-EEQESEESDQRKKTKKGTKRKRDGKSQ-EQGTMAHDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KASEIKQPPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGVKRSRLQA----SSEVAETDEESGMLSEVEK
VP-TPALRHISAEVVPMGPPPPPKPKQTRDSAFMEKLNAVDEELASSPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LEAPDITPDMYDPN----TADDEDWKVWLGGLLNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFETCVSV-VPALFQDEMGFSNMEED--
----GPEEEERVS---------------ESRPNFN-TPQTL--RFEEPLANLLNERHRTV
KELLEQLKMKKSSSRPQP-EV---------EKLKPQTETVHQTLVLDPAQRSRLQQQMQ-
QHVQLLTQIYLLTTSNPNLSSEASTTRVFLKELGTFAENSVALHQQFNPQFQTLFQPCNW
MGAMQLIEDFT-HVS-LDC----SPQKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNQNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPIEKEEHRL
PFWLKASLQSIQDE-LRNIAEGAAEGANVTTA-TESGTDQHLEKA----GPEVGSATRYP
LLM--PKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQP-SPCVQPVF-NPG-------
KISTWPTQSKIPPSNRVVQIPHLMQPNTVLQTLPGFPPVGV----SGEDTFVSPA-AQPA
VPSGPEARTSFPLS-------ESQPSLPSCS---AP----KIMLPS-LAPSKFRKPYVRR
KPTRRKV-AKVSPCVKPAPIIH-STPVIFTVPAATVKVVGLASGCNVIQPVSAAVAPNPQ
TIPITTLLVNP-SFPCPLTQPLVASSISPLIVSGNPLTLP-VPSIPEDK-AQANLGIA--
--DGKNAPQNSESTLKPQELTPLCTAVF--SKEEPRPWRLSSSPESQG------------
-------TSSESSAHGWTGVKI--EQVGQA----LEPLSPSLQESLNC-------A---P
KGLEEMVKIEAEDCVEEIS---VNFP--------GEKVKEE--CSVEADSGCPQEK----
LSSALEMRKDTVLQE-E--TQPAKSLSVSQ------DPPHEGCTSGVGSKGLP-KSTLSS
ME-QDMILSSPPGKPEDSASAEGQSVETPAGPDTGGEKDGPEEEEDDDFDDLTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERS-MSQEGESEEENSQEENSEPEEEEEE--E
TEGMEALQKED-EV----------------------------------------------
-----NDG----------AVGDAAEKPPSTLALPK--TAPEVETSITPPGE------YNT
KTA----GKSRS--GHR-----A-------------RNKRGSRARASKDTAKLLLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRRFLRQLEICFAENPSQHQKII
K-VLQGCADCLPQDTTELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVILPDVEEEEEPAKVSTASKSKRRKEIGVQNHDKE-TDWPEVAKDCSCS
CHEG-GPDSKLKKSKRRNC-HCS-SK------VCDSKSYKSKEPLELVGSSPLQEASSMP
ATKEGGQGKDMLEEEALEEQESIDVTQIR-TGRTTRRGETPTP-GSTVGSTVLCSA----
--------------------EVTLMERPLEG--STLCSPETPGLPPQTGVE-LSSVRRDQ
AGPEVVSCLDTST------ILPE------EGEDMK-SFANSETIVPLPDASETEKL----
-------------PSTVEIPASLPSPVSSRT--RDTGRRHT-------------------
--------YGK-VCT-QSWLRDSPVEAETA--HMVAPVCGTSSG-------VGASE---I
TPKAASGV-----IAEDSGTQGKGPE--GG-LPKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSSISRQLGNKTPVEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESPQHEGNQ-EEGDLDLESAV-KLESD--LVKDLGSVSLTWGPSHGRAADLEIQSIQGTR
SQLGMEDLSS---SSR-VPPQDTSVPILEAVDMAISQGITLSSLESSQPFNIHIGKGKLQ
ATGSRRGKKIALRPGPVTGEDRG----------DHPITKEPFS--GEPSEEVKEEGXXXX
XXXXX--X-XXXXXX--XXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX--XXX-XEQDSEEGERRRKKKKGTKRKRDGRGQ-EEGTLAYDLKLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVXXXXXXXXXXX-XXXXXX-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEEXXXXXXXXXXXXXXXXXXX------------XXXXXXXXXXXXXXXX
XX-XXXIRHISAEVVPMGPPPPPKPKQTRDSMFMEKLHAVDEELASSPVCI---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDD--
----GPEEEDRVT---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQSEKINQTLVLDPAQRKRLQHQMQ-
Q---------------PNLNSEANTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAVQLIEDFNTHVS-IDW----SPRKTVKK-----PAYEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIIFT-KAEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-----XXXXXXXX----XXXXXXXXXXX
XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXX-XX-XXX-------
XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXX-XXXX----XXXXXXXXXX-XXXX
XX----XXXXXXXX-------XXXXXXXXXXXXXXX----XXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX--------------
----XXXXXXXXXXXXXXXXXX--XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXKKEEVGKQL-------GE----YLEDIEVKEE--RSLELGTGSSNEG----
SSGTEVL-----------------------------------------------------
----I-VLQQEGGKNQPT---NTFLASQVPPNETGGEKDGLEEEEEEEFVDLTDE--E-D
ELSSASEESVLSVP-LQETMEKLTWLASERR-MSQESESEEENSQEENSEPEEEEE---E
AEGIESLQKED-EM----------------------------------------------
-----TDK----------VVGDPAEKPPSPVTSPQ--PAPEVES-RTPPGE-------SI
RSA----GKGWS--NHR-----V-------------NKQGN-R---SYYIYKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVQEAL-EVPGKYEDFLQIICEFES GTQK----------
---LSDWPLLLRDFAAFL LPYQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDYLQDEFSIFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPRIPAASNKGK-KEV---PNHDE-AEWPDGAKECACA
CHEG-GPDSKVKKSKRRNCSHCS-IK------ICDSKSCKSKEPHESVGSIPHEAS-PML
GTKEAVQRKDVVEEEASEERESTEATQSR-TGRTSRKGETPVAAGLAAGSTFLSPQ----
--------------------EVTLTEQLLLAEP-PPCSPEIPQLFPKTGAV-LHPVRRNQ
TGPEVVSCPKASC------KLQK------EREGPKAVDESEA-LLVRDASTELPTV----
-------------LTSPLCPVXXXXXXXXXX--XXXX-----------------------
--XXX-------XXXXXXXXX---XXXX--XXX---XXXXXX------XXXXXXXX---X
XXXXPRASRG----LGKDSGMQG--KGLGEQQPKATEATVCANNSKVSSTGEKVVLWTRK
ADCVILTMCQEQGAQPQTFSIISQQLGNKTPTEVSH-RFRELMQLFHTACKASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTAVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
SQLGMEDTSL---SSG-LLTQDTNVPILEGADVAISQGITLPSLESFHPINIRIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKESFS--GEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSVKPGTQPRKSTQLDVCDFSQEKPPRT-LIHQPDEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGNLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVPILSVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPSIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMR-
QHVQLLTQIHLLATCNPNLNSEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDC----SPHKTVKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLSMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPLEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGSVTGT-TEISSDGGLEKD----SSELGSETRYP
LLL--PKGVVLKLKPVANRFPRRAWRQRRSSVLKPLLIQP-SPCLQPSF-NPG-------
KTPARSTHSEAPPSNVVVRIPHLIQPATVLQTVPGIPPLGV----SGGDGFESPA-ALPA
VL--PEARTRFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-AKASPCVKPAPVIH-PAPVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLP-VPSTSEDK-AQVNVDIACA
VADGKNAFQGLEPKLEPQEVSPLGATVF--PKVEHSPGPPPANT----------------
---ECQEGLSENSAYRWTVVKT--EEGRKA----LEPLPQGIQESLNN-------ST--P
GVSEEIVKMEPEDGGEKIS----GSPG----RDICDDIKEE--HAVELDTGAPSEE----
LSSAREVNKQTVLQKEEEKSQPTKTPLSSQ------EPPGEGISGTDVSKGSS-KNASSS
MD-PEVMLSSPPVKLEDSSSVDGQSVGTPVGPEIGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEVESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTSASPE--TAPEVETSRTLP-------GENI
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLNRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQEWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGIQNHDKE-TEWPDGAKDCACS
CHEG-CPDSKLKKSKRRSCSHCG-SK------VCDSKSYKSKELHELVGSSPHREASPMP
GAKDAVQNKDVMEEEVPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTLTERL-LDGP-PPHSPETPQIPPKTGAV-LYTVKRNQ
VGPEVLPCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTSPVHESPSG-------IDASE---T
SPKAPRGS-----LAKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTVCQEQGAQPQTFGIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKR-SGVT
ESAQQQDDQ-EGEDLHLEAAV-KPDTD--QLPDCTSESLSWGQSHDSAGCPEVHSMQDVG
SQLSVEGTPL---SSK-MLTQRVNLAVSEAVDVPVSQEIPVPSLESSHSLPVHMGKGRLQ
STASRKGKKIAFMPGQVTREDGG----------DHTVPEEPPS--GEHAEEVKAEGGELE
MHSE---GDLPSLSS--GSQSAKPRAQPRKSFQPDGSAFPQEKPLGP-LVRQAEEDMEDG
GLFI--PT-EEQDGEESDKRKKTKKGTKRKRDGRGQ-EQGTMTYDPKVDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KASETKQPPQFVDIHLE--DDDSSDEEY
QPDEEEEDETAEESLLESDVESAASSPRGVKRSRLRL----SSEAAEADEESGVLSEVEK
VA-TPALRHISAEVVPMGPPPPPKPKQTRDSTFMEKLNAVDEELAASPVCM---------
---------------DSFQPME---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKLWLGGLLNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFETVQSV-VPSKFQDEMGFSNMEDD--
----GPEEEERVT---------------ESRPSFN-TPQAL--RFEEPLANLLNERHRTV
KELLEQLKMKKSSVRQQP-EV---------EKLKPQTEKVHQTLVLDPAQRSRLQQQMQ-
QHVQLLTQIYLLTTSNPNLSSEASTTRVFLKELGTFAENSTALHQQFNPRFQTLFQPCNW
VGAMQLIEDFT-HIS-IDC----SPHKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPICSLKANNPRDKTIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQL
--------TVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPIEKEEHRL
PFWLKASLQSIQEE-LRNLAGGATAGGSVTAA-TETSTDQHLQKT----SPVVGGDTQYP
LLL--PKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQP-SPSVQPVF-NPG-------
KMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGV----CGEDSFESPA-ALPA
MPSGSEARTSFPWS-------ESQSAPPSSS---AP----KLMLPS-LGPSKFRKPYVRR
KPTRRKG-AKASPCVKPAPIIH-PTPVIFTVPATTVKVVSLGGGCNMIQPVTAAVAPSPQ
TIPITTLLVNPTSFPCSLNQPLVASSISPLLVSSNPLALP-VTSLPEEK-AHVSLDIA--
--EGKNAPQNPEPKIKPQEPTPQCATVF--SKEEPRSWHPSADTGNQEAVSESSACSWAA
VKTEGQEGSSEKSVCGWTVVKT--EDGGHA----VQPLPQDPQDSLNS-------P---S
KDLLNMVKLEAEDCMEEIS---SDFPK----QDIGEEVKEE--CCMELDRDSPQEK----
ASSVSEMSKQTATPREE--TQAAKSPSVSQ------DAPDA---IRDASKGLP-QSTLSS
MD-QGTVLNSPPGKPEDSANADGQSVGTPAGTDTGAEKDGAEEEEEEDFDDLTQDEE--D
ELSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMETLQKED-EA----------------------------------------------
-----TDE----------AGGGAAEKPPSTLASPH--TAPEVETSITPAGE------S-I
KAA----GKGRS--SHR-----A-------------RSRRGSRARASKDASKLLLLYDED
ILDRDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQIIYEFESNAQMHSAVDLFKSL
QTLLHDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQDITELKTQMWQLLRGHDHLQDEFSIFFDHLRPAANRMGDFEEINWTE
EKEYEFDGFEEVILPEVEEEEEPAKVSTASKSKRRKEIGVQHQDKE-SEWPEAAKDGSCP
CHEG-GPESKLKKSKRRNC-HCS-SK------VCDSKSYKSKEPLELVGSGPLQEASTVP
GTKEAGQGKDMSEEETMEGQENVEVSQNK-TGRTTRKGEAPIP-GSTVRTALLCSA----
--------------------EVTPIELSLEG--PTCCSPETPRLPPQTGAV-VCSVRRNQ
AGPEVVSCLGTSS------IPPK------EGEDQK-AVANSETIAPLPETSETERL----
-------------PGTVELPAPLPSPVSLST--RDTGRRHI-------------------
--------YGK-AGT-QSWLLDNRAEAKAA--HMVAPIRGTSSG-------ASASE---A
APTASREG-----LAEDSETQGKGPE--AV-LPKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESPQHKGNQ-EEENIGPESAV-KQESD--QVKDLGSVSLSWGPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---NPR-MLIQDTNVPILEAVDVAISQGLTLPSLESSYPLNIHIGKGKLQ
ATGSRRGKKIALRPGPVTQEDRS----------DHPVIKEPFS--GEPVEEVKEEGGKPQ
MHTG---GEIPSLSS--GSQPSKPGTQPRKSSQPDICASPQEKPLRT-LAHQPEEEKEDG
GLFI--PM-EEQDNDKSEKRRKKKKGTKRKRDGRGQ--ERTLGYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVP---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKLKKSSAKQQQ-EV---------KKVKPQSEKVQQTLILDAAQRKRLQQQMQ-
QHVQLLTQIHLLSTYNPNLTSEASTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
IGAMQLIEDFNTHVS-IDW----SPHKTIKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPILVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LRQIADGAREVGNVSGA-TEISSDRGLEKD----ISELQSETRYP
LLL--PKGVVLKLKPVANRFSRRAWRQKRSSVLKPLLIRP-SPSLQPSF-NPG-------
KTPARSTQSEAPPSKMVVRIPHLIQPATVLQTVPGVPPLGV----NGGESFESPA-ALPA
ML--PEARTSFPPS-------EAQTFLTSAP---VP----KVMLPS-LAPSKFRKPCVRR
RPSKRKG-AKASPCMKPAPLIH-SAPVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSISPLIVSGNSVNLP-IPSTPEDK-AQVNVDIACP
LAEGRNAFQGLEPKLEPQELSPLCATVF--PKEEHSPGPPPADG----------------
---ECQEGLSENSAYHWTIVKT--EEGKQA----LEPLPQSFQESLNS-------PSG--
-DLEEIVKMEPEDAGEEIS----GSPE----QDICDEIKEE--HSMDLDTGTPGEE----
LSSAGEVKKQTVLQKEEERSQATKTPAASQ------EPPDEGNSGGDVSKGSP-KNASSS
MD-PEVMLSSPPGKPEDSSSVDGQSVGTPAGPEVGGEKDGPDEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
TEGMESLQKED-EM----------------------------------------------
-----TDE----------AAGDSTEKPPSTSASPK--TAPEVETSRTPPG-------ESI
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEDEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCN-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GAKDAGQGKDVMEEEAPEEQESIEATQSK-TGRTTRKGEMPVP-GLPVGSTLPSPQ----
--------------------EVLLTEQLLLDGP-PPRSPETPQFPPKSGAV-PYTVRRNQ
AGPEVLSCPKASL------RRQK------EREGQK-AVGESEALMLVWDVSKTEKL----
-------------PGTVEPSASFPSPVSSRT--RDLERRHM-------------------
--------SGK-PDTQESWLPSGRAGVKTA--DGMSPVHESSSE-------IDTSE---T
SPKPPRGG-----LAKDSGIQGKGPE--GEQQPKTTEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSVISQQLGNKSPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPN
FSRD---GVLPCWPG--WSQTTDLKNRGREMAAPQLLISVIKRYLKS-VYRYPDLDIEFH
QMLF--PISKEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPSLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NS--ESETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARTTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEGRTGFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-IKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPSADT----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--P
RDLEEVVKVEPEDAREEIS----GSPE----RDICDDIKEE--HAVELDTGIASEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSPSVDGQSMETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPGVL---QGESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTDATQSR-TVRTTRKGEMPVS-GLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------TDTSE---A
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDRGDLLSEEELDE

--------------------------------MLVYHPDEWNKSGTFKMLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVQILEGVDVAIPQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPMLKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NLELESETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSFQPSF-NPG-------
KTPVRSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPT-ALTA
MP--PEGRTSFPLS-------ESQSLLSSAP---VP----KVMLPS-LAPSKFRKSYVRR
RPSKRRG-VKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-ARVNVDIACA
VANGENAFQGLEPKLEPQEPSPLSATVF--PKVEHSPGPPPADA----------------
---ECQEGLSENSAYRWTVVKT--EEGRQA----LEPLPQGIQKSLNN-------SS--P
GDLEEVVKMEPEDAPEEIS----GSPE----HDICDDIKEE--HAVELDTGVPSEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNASSS
MD-PEVRLSSPPGKPEDSPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVS-GLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEKL----
-------------PGTVEPRASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTLS
LGRRVVVLCLYSPCAQFT--DQERSPG---------------------------------
-----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------RGARCSLSCDIKLDD----------
-----TLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETEDIPLFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEVK-PPQFVDIPLE--EDDSSDEEY
QPDDEDEDETAEESLLESDVESTASSPRGA-----KR----SRTRRSSDEEGGTLCEVEK
VT-TPVVRHISAEVVPMGPPPPPKPKQSKDSTFMEKLHAVDEELASSPVCM---------
---------------DSYQSLE---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEEWKRWLGGLMNDDVENEDELDDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDE--
----GPEDEDNVT---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLRMKKSSIKPPQ-EI---------EKSKPHNEKPLQSLVLDCTQRKRLQQQMQ-
QHVQLLTQIHLLASSNPALSSEASTTRMFLNELGNFARSSTLLRQSFYPKFQTMFQPCNL
KGALQLIEDFHAQVQ-VDW----SPRKAVKK-----SANEFPCLPKQVAWILATRRVFMY
PEL-LPICSLKANPPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLPTKTAHQL
--------TVRIKNLNMNRAPDNIIRYYKKTKQLPVLFKCCEEIQPSEWKPPVEREEHRL
PFWLKASLPSIQGE-LKQLAEDAREMPGSPDE-ESDFL--GTEKE----TSDTEYNEKYP
LLM--PKGLVLTLKPLANRFSRRAWRRQRSSALKPVLIRP-SPCLQPIS-NTI----NIQ
K-TMKLSQSEAPPSKVMVQIPRLIQPATVMQTVPGVQPLNVPAVVGSGDGLEFQN-VLSA
SHP--DSRQAFSAA-------LPPALVSSNPITFQP----KLMLPA-LAGAKIRKPCVRK
GYQKKKG-TKSAPLIKTSPLI-QPSPVILTVPATTVKVVNIGNGCNMIQPINTTVGRGTQ
AIPVTTLLVNPSTFPCPLNQPLVTSSIPSLIVSPNPVGLS-ASSV-GENEEQLNLVPSCP
AGNSKNSYPTVEPKAEPQELYATYSAVS--PKKECSTNPASSNNGSQEMVNKND------
-------------CCSWTVVEG--QENAS-EPLSV-DLLPHLED----------------
--PDETVKIEPEDSNDAIK---EVNPMQ-KRDLLCAEVKEE--FMLGLGQELNME-ACSC
PNELKEIKKEHAVCE--EKGGE-ERRALQSSPHDEQQVDAAGVTGPQVSSESP-KNHSYT
VDLEA-EFSSPLGRPEDSSSMDGQSVGTPAGPEAGGEREGQEEEDDDDFDDFTQDED--E
EMSSASEESILSVPELQETMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEE--
GEGIESLQKDD-EV----------------------------------------------
-------------------CGDVSEEPKSAFTLTK--MAPQVEAHRIPPGE-------NV
KAP----GKSRS--SHR-----A-------------RNKRG-RTRASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLRVIYEF EIS-------------
QKLLHDWPQLLTDFAAFL LPEQALECGLFEEQQAFEKSRKFLRQLEICFAEN PAHHQKII
K-VLQSCVDCLPQEIAELKTQVWQLLKGHDHLQDEFSVFFDHLRPSANRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEEDEPPKMHTASKNKKRKEIGGQNNDKE-VEWVDGMKECSCS
CHEG-TIDLKLKKSKRRTCSHCS-SK------VCENKFYKNKDSQELTASLVQQESSPQP
EGKDSGMSKEPAEE-SLESRDEGEDVQRR-TKTISRKVDSLTSASFHV--STTPRSPLEG
GIVCGRHVSSEKAA--LPDN---QVQEADVSAV-VN---------T------------TK
DSHSFITGPGCTHLQKTTQNLPQETKGSPCAERSVSDGLNQQ-H----------QGN---
----------------------------------TEGLHSESADKYAIFGHS-SKLSARE
FEGPPLLLEGK-SEAKQGWITPDRKTALGKSCCSQSPNNCVLEADDTSCIGSFPEN----
------------RLKVVTASLGQK--EEEQQQQRVTEATVCAKNSKVSSTGEKVVLWTRE
ADRVILTTCQEKGAHLETFHAISQKLGNKTASEVSH-RFRELMKLFHTSCDGSSEDEEDA
TSTSNADQLSDKDLLLSEEEPDD

------------------------------------------------MLPCKKRRTAVT
ESLQHKGNQ-DENNVDLESAV-KPETD--QVKDLRSVSLSWDPSHGQVAGFEVQFVQDAG
NQLGMEDTSL---SSG-MLSQDTNVPILEGVDVAISPGITLPSLESFHPLNIRIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--GETSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSVKPGTQPRKSTQLDVCAFSQEKPPRT-LIHQPDEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGNLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPSIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNSEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDC----SPHKTVKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMANGAREVGNVTGT-TEMSSDGGLEKD----NWELGSETRYP
LLL--PKGVVLKLKPVANRFPRKAWRQRRSSVLKPVLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSNVVVRIPHLIQPATVLQTVPGVPPLGV----SGGDGFESPA-ALPA
LP--PETRTSFPLP-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-AKASPCMKPAPVIH-PAPVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLP-IPSTSEDK-TQVNVDIACA
VADGKNAFQGLEPKLEPQEASPLAATVF--PKLEHSPGPPPADT----------------
---ECQEGLSENSAYRWTIVKT--EEGRKA----LEPLPQVIQESLNN-------ST--P
GVSEEIVKMEPEDAGEKIS----GSSE----HDICDDIKEE--HAVELDTGTPSEE----
LSSAREVNKQTGLQKEEERSQPTQTPLSSQ------EPPDEGISGTDVSKGSS-KNASSS
MD-PEVMLSSPPGKPEDSSSVDGQSVGTPVGPEIGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEVESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTSASPE--TAPEVETSRTLP-------GENI
KAV----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQEWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCGHCG-SK------VCDSKSYKSKELHELVGSSPHREASPMP
GAKDVGQSKDVMEEEVPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTLTERL-LDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLPCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEKL----
-------------PGAVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LAKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTICQEQGAQPQTFSIISQQLGNKTPAE-----------LFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPVNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEETEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TVSNDPQMRTWDCK--
----------------------------ETLKFSH-LPVGN--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDQGLEKD----NSELESETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVVRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEGRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-IKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPSTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPPADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--S
GDLEEVVKMEPEDATEEIS----GSPE----RDICDDIKEE--HAVELDTGVASEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-ET----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------DSI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGGTLPSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTRNADQRSCQE-------LDE

------------------------------------------------MLPCKKRRTTVA
ESPQHQGNQ-EEEDLDLESAV-KSSSD--QVKDLGSASLSGGPSHGRAAGLQVESVQDAG
NQLGVEDPSL---SSR-VLTQDTNTPVLEAVDAAISQGITLPSLESSQPLNVHIGKGKAQ
ATGSRRGKKITLRPGLVPQEDRG----------DHPITKEPFS--GEPCEEVKEEGGKPQ
LHPG---GAMPSLPL--GSHSAKPGAQPGKSPQPDVCACPQEKPLGT-LALQAEDETEDG
GLFI--PM-EEQGGEESEKRRRKRKGTKRKRDSRGT-EGGAWACGLKLDDAL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIQLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----CSEMTETDEEGGMLSEAEK
VT-TPAVRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGLSNVEDD--
----GPEEEERAA---------------EPRPSFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLKMKKSSGRQQQ-EV---------ERVKPQPEKVHQTLTLDPAQRGRLQQQMQ-
QHVQLLTQIHLLASSNPSLSSEASTTRIFLKELGTFAQSSVALH-QSIPGFQTLFQPCNL
LGAMQLIEDFNTHVS-IDW----SPRKTVKK-----TADEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTKFPKLLMSKYLLTGKTAHQL
--------TVRIKNLNMNRAPDNIVKFYKKTKQLPVLLKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LWRIADGARGVGSVTGA-AEVSSEPGLGKG----SSELGSETPYP
LLL--PKGVVLKLKPVASCFSRRAWRQKRPSVLKPLLIRP-SPSLQPSS-TSG-------
KTPARSTQSEAPPSKMVVRIPHVIQPATVLQTVPGVPPLGV----TGGESFESPK-ALPP
TP--SEARTSFPLS-------EPQTLLSSAP---VP----KVMLPS-LAPSKFRKPSAKP
RASKRKG-AKASLCLEPASLLH-PVPVIFTVPATTVKVVSLGSGCNVIQPVSAAVAQAPQ
TIPITTLLVNPTSFPCPLNQPLVASSIPPLIVSSNSVSLP-VPSTPEDK-AQVNVDVGCP
LAEGKNAFQGLEPKLEPQELSPLCAPIF--PKEEHSPGPPAADR----------------
---VCQEERPENSACGWTLVKA--EDGRQA----LEPLP--------------------A
GDLQEMVKMEPQDPGEDDA---SGSPG----QDTCEDIREE--HSVGVDAGFPGEE----
LSGPGELRRQPAFQQEDERSEPARTSSASR------EPGDEGDSG-DVSRGSP-KITSSC
AG-PEVVRSSPPGKCEDLASADGQALGTPAGPEAGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-AGQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDPAEKPPATFASPR--TTPEAEASSAPPG-------ESG
RAA----GKGRG--SQR-----A-------------RSRRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYRSL
QALLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEDEPPKIPTASKSKRRKEIGVQNHDKE-AEWPDGAKDCACA
CHEG-GPDSRLKKSKRRSCGHCG-GR------VCDGKPYKSKEPQELAGSSPQREASPGP
AAKEAGQGKDLLEEEATEERESTEAAQGQ-PGGSAGSGGMSIP-GLAVGSTPLSPQ----
--------------------EVTLTDRLVLGGP-RPSSLETPQLSSRTGAA-LCTVRRSQ
AAHEVLSCPQASP------GQQK------EGEDQE-AVGEPEASMPAWEASGTEKW----
-------------PGTVEPSPSFLSPVSSRT--RDVGRRQV-------------------
--------SER-SDTPESWLLAGRAAVKTA-NRMSPVRESSSSG-------FDTSE---T
SSKVPRGV-----LAKDSGTQGKGPV--GEPHPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSSISQQLGNKTPAEVSH-RFRELVQLFHTACEASSEEEDDA
TSTSNTDQLSDRGDLLSEEELDG

------------------------------------------------MLPCKKRRTTVT
ENSQDKSSQ-EEDNLDQESAV-KPESD--LLKDLGSVSLSWGPSHGRTVGFEVQSVQNVG
NQPGVEAPLL---SSR-ILTQDTNLPSLEAVDEAISQEITLTSLESSHSPNVHIGKGKLQ
ATASKRGKKVVIRPGLVTQEDRG----------DLPIMKKPFA--GEPGEEVKEEGVFI-
-P---------SLPSSFILQSVKPGAQPRKSSLPDVCASPQEKPLRT-LAQQAEEEREDV
LG-I--TI-SFQSSEENEKRRKKKKGTKRKRDGRGQ-EQGALACDLKLDDVL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPGEEDEDETAEESLLESDVESTASSPRGAKKSRLKQ----SSEIAETDEESGVLLEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPLD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRAV
KELLEQLKMKKSSARQQQ-EV---------EKLKPQAEKVHQTLILDEVQRKRLQEQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTKIFLKELGTFAQSSTALHHQSNPTFQTLFQPCNL
MGAMQLIEDFSTHVS-VDW----IPPKTMRK-----NGHEFFCLPKQVAWILATSKVFMY
PEL-LPLCSLKAKNPQDKLIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNLSRAPDNVVKFYKKTKQLPVLSKCCEEVQPHERKPPLEREEHRL
PFWLKASLPSIQEE-LRLGAHDGRAVGNGTGT-TEVSADRGLEKA----RSEPGSETRYP
LLL--PKGVVLKLKPVANRFSRKTWRQKRSSV----------------------------
-----------PPSKMVVRVPQLIQPAAVLQPAPGVPPLGL----SGDNSFESPA-ALST
VP--PEARTSFLLS-------ESQALPPSAP---VP----KVMLPS-LGP-RFRKPCVRR
KPSRRKG-AKVFPCPKPAPLIH-SAPVIFTVPATTVKVVSLGSGCNVIQPVSAAVARSPQ
TIPITTLLVNPASFPCPLSQPLVASSISPLIVSGNSVNLP-VSSTPEDK-ARVNVDISCP
LAEGKNAFQSLEPKLEPQEVTPLCAPVF--PKEEYGPRPLLAGREG--------------
--REGQVGLSANSACGWTVVSK--EEGRQG----LEPLPQGFHGIRNS-------S---P
ADLKEAVKMEPEDPGEAIS---SGPPE----QRIGDEIKKE--RFVEWDSGSPREG----
LSSARVLKKQAVLQEEEDRSQPAQTPSASW------EPPGEGSAVGDGS------SAPSS
VE-PEMALSSAPGKPEEASGVGGPSAGGPAGPEVGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----VDD----------TGGDTAEKPPSTLASPT--TAPEVETCRIPAG-------ENI
KAA----GKGRS--SHR-----A-------------RTKRGSRARASKDASKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSSQRQTAVDLYKSL
QILLRDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCVPHEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEISWTE
EKEYEFDGFEEVALPDVEEEEEAPKIPTASKNKRRKEAGAQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCS-GT-----KVCDSKPYKHKEPPESVSSSPHGEASPGR
SAKEAGPGKELGEEEALEDPESTDAPQSR-AGRAARKGEAPIP-GSAVRSLLLSPQ----
--------------------EVPLTDHLPEGP--PAP-PETPQCPPPTAAE-LDAVQRSQ
AGPEGPSASAC--A-----R-PE------EGASRK-AAGDSEAASRGWDALQPEPL----
-------------LGTVETPAPSLSPASSRT--RVIGRRLT-------------------
--------PGK-PDPQDSWLPSSRAGARRA--NRTSPGHEPSTG-------MDTSE---T
APEAPKRS-----LAKDGGVQGRGLE--GEQQLKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSSISRQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPSKKRRTSET
EFPQHQGNL-EEEDLDLESAV-QPESD--QVKDLGSVSLAWGRSHGSAAGLEVESVQDAG
NQLGVEDPSL---SSR-VLTQDTNAAVLEAVNVAISTGIALPSLESSQPLNIHIDKEKLL
AIGSKRGKKMTLRPKP----DEG----------DHLITKEPFS--GEPSEEVKEEGGKPQ
MHSG---EEMPLLPS--GSHSVKLGAQPRKSSQPDACASPQGKPFRT-SDHQAEEEIEDD
GLFI--PM-EEQDSEESEKRQKKKKGTKRKRDGRGQ-EEGTLAYDPKLDDRL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDINLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMNETDEENGILSEAEK
IA-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEEWKLWLGGLMNDDVGNEDEADDDDDPEYNFLEDR-DE
PDTEDFRTDRAV-RITKKE-VNGLMEE-----LFE---------TFQDEMGFPSMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTM
KELLEQLKLRKASAKQQQ-EV---------EKVKPQTEKVPQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLSTSNPNLNSEASTTRIFLEELGTFAQSSIALHHQFNPKFQTLFQPCNL
TGAMKLIEDFNTHVS-IDW----SPRKTVKTV----TACKFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKNSFT-KAEDNLLVLGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNRSMNRAPDNIFKFYKKTKQLPVFGKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-MQHIADGAREAGNVTGT-TEIKPDPDVGKT----SLELESETRYP
LLL--PKGVVLKLKPVANCFSRKGWRQKRSSTLKPLLIRP-SPSLQPTF-NSG-------
KIPPRSTQSEAPPSKMVVRIPQTIQPATVLQTVPAVPQLRV----TGGDSFESST-VLPT
IP--PEARTSFPLS-------EPQTLFSSAP---VP----KIMLPS-LAPSKFRKPYVKR
RGPKKKG-TKASLCLKSVPLIN-SAPVIFTVPAATVKVVSLGSGCNMIQPVNATVAPSSQ
ALPITTLLVNPTSFPCPLNQPLVASSIPPLIVSGNSVNLP-VQSASEEK-AQVSMDVGCP
LDEGKNAFPGLVPKLEPQDLSPLCAPVF--PKKEHSPGPLPSDG----------------
---VCPEDLSENSAYIWTVVKT--EEGRQV----VEPLPQGFQESLSS-------P---P
ENAEKIVKMEPNDPGEEVP---RASPK----HTIYDDVKEE--YSVELDTGFPSEE----
SSGGREAKKQTVLQKEEERNQLAKTPSASQ------EPPDGGNSG-NVSKESP-KNASSS
VD-PDTVPSSLPGKPEDVLSIDGQLAGTPARPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEEEAE
AEGMESLQKED-GM----------------------------------------------
-----TDE----------AIGDLAEKPPTTFASPQ--TAPEE-TSRTPAG-------ESI
KAS----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDEN
ILERDPLREQKDLAFAQAYLTRVREALQHIPGRYEDFLQVIYEFESSTQRQTAVDLYKSL
KILLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQSCADCLPQEITELKTQMWHLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTAPKNKRRKEIGVQNHDKE-TEWPDGAKDCACA
CHEG-GPDSKLKKSKRRNCSHCS-SK------VYDSKSYKSKEPHELVGGSPHREASPMP
GAKEAGQGKDVMEEEAPEERETTEATQSR-TGRSTRKGEMPIS-GLAVGSTLLSPQ----
--------------------EVILTERQLLLDGPPPSSPETPQLPSNTGVV-LD-TRTDQ
VKPEASCCTEL--P-----RLQD------EGEGHQ-AAGDAESSTPVCDASET-QC----
-------------PGTLEPPASFPSPVSSRT--RDLGRGQV-------------------
--------SGK-PDTQESWLPSSRTGMKTS--DRKSSVLESSSR-------IDTSE---T
SPKTPKGG-----LAKDSGVQVRGPE--GEQQPKATEVTVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFRIISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTLT
ESPQHQGNQ-EEDDLDLESAV-KPESD--QVKDLGSVSVSWGPSYGRAAGLEVQSVQDAG
SQLGMEDPSL---SSG-MLTQDTNTPVVEAVDVAISQGVTLPSLESSQPLNIHIGKGKLQ
ATSSRRGKKITLRPGSLAQEDRG----------DHLIAKEPFS--GDPSEEFKEEGGKSQ
MHSG---GEMPSLPS--DSHSAKPAAQPRKSSQPDVCASPQEKPLRT-LAHQAEEEIEDG
GLFI--PM-EEQDSEENEKRRKKKKGTKRKRDGKGQ-EEGTLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEECVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMRKSSAKQQQ-EV---------ERVKPQSEKVHQTLILDPAQRRRLQQQMQ-
QHVQLLTQIHLLATSNPSLSSEASTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAVQLIEDFNTHVS-VDW----SPRKTVKK-----TAYEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTRQLPILMKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LQRIADDAREVGNVTGT-TEITSDPGLGKG----SSELGSETRYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSVLKPLLIRP-SPSLQPSS-SSG-------
KTAARSTQSEAPPSKMVVPLPHVIQPATVLQTVPGGPPLGV----PGGDSFESPA-ALPT
TP--PEARTSFPQP-------EPQTLLSSAP---VP----KVMLPS-LSPSKFRKPCVKR
RASKRKG-AKASLCLKPAPLIH-PAPVIFTVPATTVKVVSLGSGCNMIQPVSATVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSIPPLIVSGNSVNLS-VPSAPEDK-AQVSVDIGCP
LAEGKNAFQGLEPKLEPQELSPLCAAVF--PKEEHSPGPPPADR----------------
---VCQEQLSEGNAYGWTLVKT--EEGRQA----AEPLPQGFQESLNT--------S--P
EDLEEIIKMEPKDPGEDIS---GGSPE----QDSCDEIKEE--HAVELDTGFTSEE----
SSGPREVKKQTVLQQEEERSQPAKTPSASQ------EPADEGNSG-DVSKGSP-RNASTS
TD-PEMVLSSPSGKPEDLCSVDGQSVGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AIGDPAEKPPTTFASPK--TAPEVETSKSPPG-------ENI
KAA----GKGRS--NHR-----V-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESNTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGV-----E-AEWPDGAKDCACC
CHEG-GPDSKMKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGGSPHGEASPVP
GAKEAGQGKDVMEEETPEERESTEATQSR-TDRSTRKGEMPVPAGLAAGSTLLSPQ----
--------------------EVTFTDQLLLDGP-PPCSPETPQLPSKTGTV-LCAVRSNQ
AGPEVLSCPRASP------RLQD------EGEGHK-PGHESQASMLVWNASETEKL----
-------------PGTVEPPASFPSPVSSRT--ADLGGRQV-------------------
--------SGK-PDTQESWLPSSRAGVTA--DGVSPVHGSSSLG-------TDTSE---T
SPKAPRGG-----LAKDSGIQGKGPV--GEPQTKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

MLSLVHKAASPGLGLSR-P------SPSGLERTPASTSAGWNKSGTFKMMPCKKRRTTAT
ESPQHKGNP-EEDNLDVESAV-KPESN--QTKDLGSVSISWGPNHGRAVGLEVQSLQDAG
NQLGVEDSSL---SSR-TLIQDTNLPILEAVDVAISQEITLPSLVSSHPLNISIGKGKLQ
ASASKRGKKTVLRPGSVTQEDRS----------DHSIIKEPFT--GQPSEEVKEEEGKPQ
MHSG---GEIPLPPS--GSQSAKPGVQPRKPSQPDVCASSQEKSLRI-LAYQAEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGKGQ-EQRTLACDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGAKKCKLRQ---SS-EMTETDEESGILSEAEK
VT-TPAVRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERLKPQSEKVHQTLILDSAQRKRLQQQMQ-
QHVQLLTQIHLLAISNPNLSLEASTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDW----SPRKTVKK-----TACELPCLPKQVAWVLATSKVFMY
PEL-LPVCSLKAKNPQDKIIFT-KAEDNLLALGLKHFEGTESPKPLISKYLITCKTAHQL
--------TVRIKNLNLNKAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQDE-LRHMADRARELGNVTGT-TEIKAEQDLEKA----RSELGSETQYP
LLL--PKGVVLKLKPVADRLSRKAWRQKRSSVLKPLLIRP-SPSLQPSF-NPG-------
KTPARSTQCEAPPSKMVVRFPHLIQPATVLQPVSGVPTLGV----TGDDSFESPV-AMST
VP--PKARTGFPLS-------EPQTLLSSAP---VP----KVMLPA-LAPSKFRKPCVRR
KPSRRKG-TKASPCLKTAHLIH-PAPVIFTVPATTVKVVSLASGCNVIQPVNAAVAPSPQ
TIPITTLLVNPTSFSCPLNQPLVASSISPLIVSGNSVNLPPVPSTPEDK-AQRNVDIACP
LTERKNAFQTLEPKLEPQELAPLCAAVF--PKEEHSPGPMPADG----------------
---ESQEALLENSAYRWTLVKT--EEGRQA----LEPVPQGFQESLKS-------PC---
EDLKTIIKMEPEDPGEEIS---SRSTE----QDVCNEIKEE--QLLELDTGSLREE----
LSDAREVKKQAGQQEEEERRQSAQPPATWQ------APTAQGNTGGDMNKGSP-KNVPSS
MD-PDMVLSSPPGKPEDSSSVDGHSVGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEQEEEEEE--E
AEGMENLQKED-EM----------------------------------------------
-----TDE----------AVGDAAEKPPSTLASPQ--TAPEVETSRTPPG-------ESI
KAA----GKARS--NHR-----S-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPSASKNKRRKEVGVQNHDKE-TEWTDGAKDCSCS
CHEG-GPDSKLKKSKRRNCSHCS-TK------VCDSKSYKSKELHELVGSSPHREASPMP
GAKEAGQGTDVVEEEAPEEQESTEVTQSR-TSRTTRKGEASIP-GLLVGSSFSSPQ----
--------------------EEVTLTQQLLDSP-PPCSPETPQLPPQTGAV-LHPGRKNQ
AGPEILSCPSAHS------GLQN------EGEGQK-VVGDSEDSMLVWDTPETEKL----
-------------PTAAETPASFLSPVSSRT--RDVGRRHV-------------------
--------SGK-PDTQESWKPSGRAEVKTV--NRMSPVPESSSG-------IDTSK---A
SPEAPGGV-----LAKDSRIQGRGPE--WEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVAH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLFSEEDADE

------------------------------------------MALSLKMLPCKKRRAAAA
GPHSPRERSGSGEDGEPPPPQPPPPPP--AAASSAVAAAVWRTPAEA-LPRGGRRPPQEG
N-EGRPGAAE---PCA-A--------------------------------PPERGEDAKR
LEGGKEGK----TPKLHTEVEANVQRDLCLTDNPSAVQESPSR--SNLQLAVRSPAA---
------------------------------------VKLLKS------------------
-----TRP-EEQDGEDIERRKRRRKANKRKREGKSQEEERTLSCDIKLDD----------
-----TLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETEDIPLFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEVK-PPQFVDIPLE--EDDSSDEEY
QPDDEDEDETAEESLLESDVESTASSPRGA-----KR----SRTRRSSDEEGGALCEVEK
VP-TPVVRHISAEVVPMGPPPPPKPKQSKDSTFMEKLHAVDEELASSPVCM---------
---------------DSYQPLE---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEEWKRWLGGLMNDDVENEDELDDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDE--
----GPEDEDNIT---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLRMKKSSIKPPQ-EA---------EKAKPQNEKPLQSLVLDCAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPALSSEASTTKMFLSELGNFARSSTLLRQSFYPKFQTMFQPCNL
KGALQLVEDFHAQVQ-VDC----SPRKAVKK-----SASDFPCLPKQVAWILATRRVFMY
PEL-LPICSLKANPPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLPTKTAHQL
--------TVRIKNLNMNRAPDNIIRHYKKTKQLPVLFKCCDEIQPNEWKPPVEREEHRL
PFWLKASLPSIQGE-LKQLAEDAREVPGSTDE-ESDFL--GTEKE----TSDTECGEKYP
LLM--PKGLVLTLKPLANRFSRRAWRRQKSSALKPVLIRP-SPCLQPSS-NTV----NIQ
K-TVKLSQSEAPPGKVMVQIPQLIQPATVVQAVPGVQPLNVPAVVGSGDGLEFQN-VLSA
SHP--DSRQGFSGA-------VPPALVSSSPVTFQP----KLMLPD-LAGTKIRKPCVRK
VYQKKKG-TKAAPLIKAPPLI-QPSPVILTVPATTVKVVNIGNGCNMIQSINTAVGRGTQ
AIPVTTLLVNPSTFPCPLNQPLVTSSIPSLIVSPNPVGLT-APSV-AESEEQLNLLPSCP
AGNNKNSCPVVEPKAEPQELCVPCSAAS--PKKECSANPTASNNTSQEKVNKSD------
-------------CCSWTMVKA--EENVS-EPLSV-DLLPHLED----------------
--SDKTVKSEAEDSNDAVK---EVNPVQ-KRNLLCVEVKEE--FMLGLGQELNMEAACSC
ANELKEIKKEHALCE--EKGGEEERRALQSSPRDEPQREAGAVGGAQACSESP-KNHSSS
ADVEA-EFSSPLGRPEDSSSMDGQSVGTPAGPEAGGEREGQEEEEDDDFDDFTQDED--E
EMSSASEESILSVPELQETMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEE--
GEGMESSQKDD-EV----------------------------------------------
-------------------CGDVSEEPKSAFTLTN--MAPQVEAHRMPPGE-------NM
KAP----GKSRS--SHR-----A-------------RNKRG-RARASKDTSKLLLLYDEN
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLRVIYEFEISMDKQTAVDLYFTL
QKLLHDWPQLLTDFAAFLLPEQALECGLFEEQQAFEKSRKFLRQLEICFAENPAHHQKII
K-VLQSSVDCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEEDEPPKIHAAPKNKKRKEIGGQNNDKE-AEWGDAMKECSCS
CHEG-SGELKLKKSKRRSCSHCS-SK------VCENKFYKNKDSQELSANLVQQESSPQP
EGKDSGTSKEPAEE-NLENRDEGEDVQSR-TRTVSRKGEPLPAGS-----------HPEG
RAVCSRHTSPDKAA--LPER---RVQEGGVSAA-VSA---------------------AK
DSPSFIAVPGWTRLQKAAPKLPQETKGSPCSTGSGSEGLKQQ-H-----------QG-DV
DASLELSRDLLLSSRSATVKGSVRPGSSKNSLCQTEGLPSD---SSDKFGHS-SKLSARE
FEGSPLPLEGK-SEAKQSWITPARKPALGASAF---------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRTTVT
ESPQHKEHQ-EEDNINLEAAA-KQESD--QVKDLESVSLSWSPSRGRVADFEVQSVQDTG
NELGMEDTSV---NPT-MLMQDTNVPVLESVDVAISQGITLPSSEPSYPLNIHIGKGKLQ
VTGSRRGKKIALRPGPVTQEDRS----------DHAIVKRPFS--GEPNEGVKGEGGKPQ
THSG---GETPLLSS--GSQSSKPETQPRKSSQPEACAYPQEKPLRN-LTHPSEEEIEDD
GLFI--PM-EEQDNEEREKRRRKKKGTKRKRDGRGQ--ERTLGYDLKLDDML--------
-------DRTLEDGARQHSLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KASEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGSKKSRLRQ----SSEMTETDEESGMLSEAEK
VT-TPSIRHISAEVVPMGPPPPPKPKQTKDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEATTDDDSVYNKSESNLEE
TLLSDLSTFKRLKVKKEKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQRRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKVQQTLILDSAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPSLSSEASTTRIFLKELGTFAQSSIALHHQLSPRFQTLFQPCNL
IGAMQLIEDFNTHVN-IDW----SPHKTVKK-----TGFAFFIILKKIFFLCCTAFFFLR
QRQ-SLTMALYHSDSRAPAEVT-KYLKNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLSMNRTPDNIIKFYKKTKQLPILAKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LQHLTDGAREAGKGTGD-TKISSDQ--EKD----ASALGSETQYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSTLKPLLIRP-SPSLQTGF-NPG-------
KTLARSTQSEAPPSKMVVRVPPLIQPTAVLQTVPGVPPLGA----SGSDGFESPI-APPI
MP--SEGNAGFPLS-------EFQTMLSSAP---VP----KVMLPS-LAPSKFRKPCVRR
KPSKVKG-AKASPGVKAAPVIH-STPVIFTVPAATVKIVSLSSGCNMIQPVNAAVAPSTQ
TIPITTLLVNPTSFPCPLNQPLMASSISPLIVSGNSVNLP-VPSTPEDK-AQVNVDIACP
LAEEKNVFQGLEPKVEPQELSPSCAPVF--PKEEHSPGPLPTGR----------------
---ECPEGSSETSAYRWTIIKT--EEGRQA----LELLPQSSQKSLNS-------S---S
GDLQEVVKMEPEDAGEEIS----EYSE----QDICEEIKEE--QSMDLDTGSPREE----
LTKAQEAKKHTVLQKEEERSQPAQTPVASK------EPPAERNLGGDVSKGSP-KNPLFF
TD-HEVMLSSPPGKPEDASSVDGQSLGTPAGPETVGEKDGPDEEEDEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMETLQKED-EM----------------------------------------------
-----TDG----------VVGVSAEKPPSTLTSPK--TAPDVETSRTSSGVL---QGESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDASKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALHHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEIAELKTQMWHLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHDG-GPDSKLKKSKKRNCIHCG-SK------VCDTKSYKSKEPLELVGSSPHREASPMA
GAKEAGQNKDVVGEEVSEEQEITEATQSRSIGRSSRKGEMPVP-GLATASTVLSSP----
--------------------EVVFTERLLLGDT-PPCSPEAPQFLPKSGAV-PYTVRRNL
AGPEVLSCPKSSP------RLQR------EREGQK-AGGDSQALLLVWDASETEKS----
-------------LGTVEPPASFLSPVSLRT--RDLGRTHM-------------------
--------SGN-PDNLENWLPSSRVGVKTA--DRVSPVHESSPG-------IDNSE---T
SSKAPRRG-----LAKDSGIHGKGLE--GEQQPKTTEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCKEQGAQPQTFSIISQQLGNKSPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLS-EEELDE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------WKQWLGSLMTDDMENEDEADDDDDPEYNFLEDM-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGLSNVEDE--
----GLEDEDSAA---------------EARPNFN-TPQVL--RFEEPLANLLNEQHRTV
KEQLEQLRMKKSAAKTPQ-EA---------EKAKLRSEKPLQALALDAGQRKRLQQQMQ-
QHVQLLMQIYLLSSANPSLSSEANTTRLLLTELDSFAQSSTFLAQPLGHKFQTAFQPCNL
REALQLITDFQSDVN-IDW----SPRKAIKK-----NVNDFVPLPKPIAWILATRRVFMH
PEL-LPTCSLKAKTPRDKIVFT-KGEDNLLALGLKHFEGTEFPKPLISKYLLTTKTAHQL
--------TVRIKNLNMNRVPDNILRYYKTTKQLPVLSRLCEEVQPHDRKPPLEHDEHHL
PFWLKASLPSIQEE-LEKMSREASVPG----------------SE----LAGPGQGHKYP
LRM--PEGVQWMLRPLNSCLFRKTWRRQRPAAAKPLPVRT-GLCSPPAG-GNN----NFF
KMAARHPQPEAPPSKGSGRVPRLIQPAPFLQPLP----VNLQPAPGNGANFELQG-LLPT
RHP--NLGAQ--------------NVIPALPVAFQP----KMMLPV-L---RVRKPGPTR
GYQKKKAPLRAAPLLKPAPLL-QPTPVIFTVPTAAVNVVGIANGCNVLAA----TPASPQ
PIPITTLLVNPSPFPCPLNQPLAVPSAPPLVVTSPMASTA-VTVA---------------
----NVMAPGAGPNQAESQEPSPCAAVS--SKEHDA------------------------
---------------LWSSDAN--T----VAP--VETSVEMME-----------------
ENAGPIEKI-----QDDSS---EAEPLPETPSSVGPLLNED--VVLGLGQELDIEPPPRP
AEEPKESPRKQGSSE--------------------------EGKGDLGASTER-TPSPCK
DTSSAPESVSSQPKPE-------GGPSLPVSQEAGGEKDGPEEEEEEDFDDYIHDEED-E
EMSSASEESVLSVPELQETMEKLTWLASERR-LSQEGDSEEENSQEENSEPEEEEEEEEE
GENLESLQKED-EM----------------------------------------------
-----TDE----------VA-DPADRPALSLTLTC--TVPEVEPRRSPPGE-------NA
KAP----GKSRN--SYR-----T-------------RAKRG-RSRASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLSRVREALRSVPGKYEEFLRIIYEFESNAQKQTAVDLYAQL
RSVLQGCPQLLTDFAAFLLPEQALECGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQSCAECLPQEIVELKTQMWQLLKGHDHLQDEFSVFFDHLRPSASRLGDFEEINWTE
EKEYEFDGFEEVSLPEVEEEEEPPKMHTASKNKRRKELGGQNTDKE-LEWAEGAKECFCS
CHEA-TGDLRMKRSKRRSCSHCS-NK------AAEGKLFKQKDTQELADGLGPQEASLCP
EGKDPVE-------ERLELREDGELPLNR-MRSAARRADPSGAGLWGMKGCM--------
--RCFFFVCTPKAPTWLDKSGPNIMELRKEKGM-RSMCSSVLFSPPFPGPR-ME-----G
K---PPSCKDVPSEAKT--------PSEPCSVPDPPAATLAT-SAFSPKAPQPRSSPTGV
GSEV---------------GVALRSDEASSVLCRDISEPATH------------------
--GATSPQNNK---RTESDPVPSSRVLLRDTEMEN-----------------RPSS---P
E---------------TRALRSKD-TNGGLQAQRAAEATVCAKNIKVSSTGEKVVLWTRE
ADRVILTTCQERGATPDTFGAISQRLCNKTADEVSH-RFRELMALFHTACDVSSEDEDDG
LSISHTDQLSDKDPVLSEEEQEE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------QTEEETEDV
GLF--IPL-EEQDGEEGERRKKRRKATKRKREEKGQEEEASLACDIKLDD----------
-----MLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPAWNISPIK-KANEIK-PPQFVDIPLE--EDDSSDEEY
QPEEEDEDETAEESLLESDVESSASSPRGAKRSRTRR----SSDMIETDEEGVTLSEVEK
IS-TPPIRHISAEVVPMGPPPPPKPKQSKDSTFMEKLHAVDEELASSPVCM---------
---------------DSYQSLD---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TVEDEDWKRWLGGLMNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDE--
----GPEDEDAVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLRIKKSSTKQPQ-ET---------ERTKPQIEKPLQTLVLDIGQRKRLHQQMQ-
QHVQLLSQIHLLTSSNPSLSSEASTTRMFLTELSNFAHSSMLLRQPFHPKFQTVFQPCNL
KGALQLIEDFHAQVK-VDW----SPHKTVKK-----SANEFPCLPKQVAWILATRKVFMY
PEL-LPICSLKAKAPQNKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLPAKTAHQL
--------TVRIKNLNMNRAPDNIIKYYKRTKQLPILFKCCEEIQPSEWKPPVEREEQHL
PFWLKASLPSIQRE-LKQLAEDAGEAAGSPSA-ESALLRTG--KD----IMESQCDEKYP
LLM--PKGIVLTLKPLANRFSRRAWRGQGSAALKPLLIRP-TPCLQPSA-NPSANAINIQ
KAAVKLPQPDAPPSKVVVQIPQLIQPAAVLQAAPGMPHLNIPSAVGSGDRFEFQS-LLST
LQP--DSQTSVPAA-------VPPAQVSSAPLTFQT----KV-LPA-LTASKIRKPCVRR
GYQKRRG-TKPAPLIKAAPLI-QPAPVIFTVPAATVKVLSLSNGCNMIQPINTSVGRGTQ
TIPITTLLVNPTTFPCPLNQTLVSTSLPPLIALYSSVHFP-PSL--DSLPKRLNPLASCC
GVSDENSHPVAEPKEEPQELYASCSAIS--PKKEDGTGPATPDSDSQDKVKESD------
-------------CCSWIVVET--TKEKALEPLPL-DLLPQLD-----------------
--LEETVKTEPADPSDALE---ETHPTQEKKNLVSAEIKEE--FILDLGQELDMEVPSEH
PSEQKEIKKECTS---PQEKGEEKGQDEEVPAQDEQQLENIDTAGMETSNESS-KNASHS
ADVDA-EFSSPFGKPEDSSSGDGQSVGTPAGPEVGGEKDGQEEEEEEDFDDFTQDEEDEE
EMSSASEESVLSVPELQETMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEEGE
GEGMEQSQKED-EM----------------------------------------------
-----TDE----------IAEDVAEEPKSAFAFTN--VAPEVETSRLPPDE-------NA
KVP----GKTRN--SQR-----A-------------RSKRG-RARASKDTSKLLLLYDEE
ILERDPLREQKDLAFAQAYLNRVRDALRDVPGKYDDFLRVIYEFETSTHKPTAVDLYATL
QTLLQEWPQLLTDFAAFLLPEQALECGLFEEQQAFDKSRKFLRQLEICFAENPTHHQKII
K-VLQSCADCLPQDIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPSARRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEEEEAPKLHTASKNKKRKEIGGQNNDKE-ADWVEGVKECACS
CHDG-SSDPKLKKSKRRSCSHSS-CK------VCDSKCYKNKDSQELVTSLTQRELSPQP
EGQEPGKCKEPAEE-SLECRDDVANGQSR-TKPTSRRADALGSGLLAGPGSDIPRSPLEG
QLICRGTSE---GA--LPKS---RVPELSAPPT--------PLGPP------------RD
-G--VAAG--ARSERET--SLKQ----RRGGTGEGSLGLAKQ-V----------SGA-D-
----------------SAANTGFPGGSSRQ----TIALRFKS---SASAGHPPPTPGGR-
-EGARL--AFP-PEGKRSWVGPVRNLRLKTLDKS---SHLPSEAAGSGCAGVSPSQ---E
SQRRLQSSSSDCRFEALECGTGRG-QREDEQQQKIMEATVCAKNSKVSSTGEKVVLWTRE
ADRVILTTCQERGAHLDTFSAISQQLGNKTASEVSH-RFRELMRLFHTSCDGSSEEEEDA
TSTSNTDQLSDKDLLLSEEEQDD

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--VL--GLFAEQDSGESEKRRKKKKGTKRKRDGKGQ-EEGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGLLPEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VEELFETKKAPFLPP---------QFQDEMGFSNMEDD--
----GPEEEEHVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKPQQ-EV---------ERVKPRAEKVPQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLAASNLNLSSEASTTKIFLKELGMFAQSSVALHHQFNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-VDW----SPRKTVKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPKHKMTFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLLKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQDE-LRRLAGGAREAGNGTGT-AEIGAEQGLEKN----GAELGSETQYP
LLL--PKGVVLNLKPVANRFSRKAWRQKRSSVLKPLLIRP-NPSLQPGF-NPG-------
KTPARSTQSEAPPSKI-VRIPHLIHPATGTPAVPGVSPLGI----SGTDSFESST-ALPT
MS--LEARPSFPLS-------DSQTVLSSAP---VP----KIMLPS-LGPSKFRKPCVRR
RSSKRKG-SKSSPCLKTAPLIS-PPPVIFTVPATTVKVVSLGSGCNVIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSISPLIVSSNSVNLP-VPPTPEDE-AHVNVDIACP
LVEGQSAFQSPVPKLEPQELSPVCATVF--PKEERSPGPPIANR----------------
---ESQEGLSENCAY-WTIVKT--EEGTQT----LEPLPPRLQEHLNS-------A---P
GGLDGTVKVEPEDAGEEVS---SGPPV----QDVCDGVKEE--HSVEMDIVSAGEG----
SSSARDVKKQTVIRKEGEKGPPAKAPSASQ------EPADEGNSGE-VS-RSP-QKALSS
VD-PEMLHSSTPGKPEDSSTVDGQSAGTPAGPEAGGQKDGPEEEEEEDFDDLTQDEE--E
EISSASEESVLSVPELQETMEKLTWLASERR-MS--------------------------
-----SLQKED-EM----------------------------------------------
-----TDE----------AVGDAAEKPPSTSASPK--TAPEVEASRAPPDVL---QGESI
KAA----AKSRT--SHR-----S-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHFPGKYEDFLQVIYEFESSTQRQTAVDLYKNL
QILLQDWPQLLRDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEDEPSKIPTASKGKRRKEIGVQHHDKD-SEWPDGAKDCACS
CHEG-GPDSKLKKNKKKTCSHCS-SK------VCDSKSCKNKEPQELVGSSPQREASPMP
GAKEAGRGKDAAEEDAPEERESTEATQSR-AGRPSRKGEVLGP-GLAAGSALASPQ----
--------------------EVTVTDRLLRDGP-PPGSPEAPQRPPRAGAG-PVI-VRSQ
AGPEGLSCPSASP------RLER------EREDHK-AVEGSEASLPLWDAPSTEQL----
-------------PGTVDPPASFPSPVSSRT--RDVRRRQV-------------------
--------SGK-PGAQESWLPSSGAAAQAT--DTLPPGREPSSG-------ADASE---T
SPKASQGG-----LAKDSGVQGRGPE--GEHPPKAAEATVCANNSKVSSTGEKVVLWTRE
ADRVILTVCQEQGAQPQTFSVISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEDELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEETEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NSELEGETRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PEGRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-IKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCQLNQPLVASSVSPLIVSGNSVNLP-IPTTPEDK-AHVNVDIACA
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPPADA----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--S
GDLEEVVKMEPEDATEEIS----GSPE----RDICDDIKEE--HAVELDTGVASEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSE------EHPDEGTSGTDVNKGSS-KNALSS
MD-PEVRLSSPPGKPEDSPSVDCQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-ET----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------DSI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKE-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEGTQSR-TVRTTRKGEMPVSAGLPVGGTLSSPR----
--------------------EVTLTERLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHVSFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNADQLSDRGDLLSEEELDE

------------------------------------------------MLPCKKRRTTAS
ESPQDTGNP-EESDLDLQSAV-KSDSD--QVKDLGSVTLSWGSCHGRAAGLEVQSLQDAG
NELGMDDPSV---TCR-VPPQDTDIPVLEAVDVAISQGITLPSLESPHALSTHVGKGKPQ
ASGSRRGKKIVLRPGPVAQEDKG----------DRPVLKEPFS--GEPSEEVKEEGGKPQ
MHSGG--E-MLSLPS--GSQSAKPGAQPRKSSQPDVCVSPQEKPHRT-LALQAEEEMEDG
GLF--IPM-EEQDNEESEKRRKKKKGAKRKREGKGQ-EEGTLTYDVKLDD----------
-----MLDRILEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-XXXXXXXXXX--XXXXXXXXX
XXXXXXXXXXXXXSVLESDVESTASSPRGAKRSRLRQ----SSEMAETDEESSTLSEXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------
---------------XXXXPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKAWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITXXX-XXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXX--
----XXX---XXX-----------------XXXXX-XXXXX--XXX-XXXXXXXXXXXXX
X-XXXXXXX---XXXXXX-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XHVQLLTQIHLLATSNPNLNLEANTTRIFLKELGIFAKSSIALHQPFNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDW----NPRKTVKK-----TXXXXXXXXXXXXXXXXXXXXXXX
XXX---------------------------------------------XXXX--------
---------XXX-----------XXXXXXX------XX----------------------
-XXX-------------------------------XXX--X--XX----X--------X-
XXX-----XXXX-------------------XXXXXXX------------X-X----XX-
X-------------------------XX--------XXXXX----XXXXXX-X---XX--
------------------------------XX-XXX----XX-XXX--------------
---------------------------XX------XXXXXXX--XXX-------------
-----XXXX---------------------XX---XXXXX-XXXXXXXX-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------------XXXXXXXXXCDEIKEH--SVLDTASPA------EE
LSSTREGNRQKVLQREEERGGPARTPPVS------QDPPGDGDSGRDGSKGSP-RSASSS
TDPEM-VRSSPPGKPEDPSGADGQSVETTAGPEAGGEKEGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-VSQEGESEE--SQEENSEPEEEREEASL
RE-------ND-DD----------------------------------------------
-----ADS-----------------AAPLTLT---SPTTAEVETSRTPPGE-------NV
KAA----GKSRS--SHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPEVEEEEEPPKIPTTSKNKRRKEIGVQNHDKE-TEWPEGAKDCACS
CHDG-GPDSKLKKSKRKTCSHCS-SK------VCDSKSYKSKEAQEMVGSSPHREASPMP
GAKEAGQGKDVLEEEASEERESTEAVQSE-SGRTTRKRELPTAAGLAV-GSTLP------
--------SPQEVT--VTER---PILDGP-PPR-SPE---TPQLPPHTGIV-LHTVGRNQ
AGPEVLSCPKT------SPRLEK------EREGQKAVGEAEA-S----------VLAWGT
ADTTELP-------GTGVSPASFLSPVSSRT--RDRGKRHT-------------------
--------SGK-PDIQNSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----
------------XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVSH-RFRELMQLFHTACEASSEDEEDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTAVT
ESLQHKGNQ-EENNVDVESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILEGVDVAISQGITLPSLESFHPLNIRIGKGKLQ
STGSKRGKKITLRPGPVTQEDRR----------GHPILKEPCS--GDPSEEVKEEGGRPQ
MYSE---GEIPSLPS--GSQSVKPGTQPRKSTQLDVCAFSQEKPPRT-LVHQPDEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGNLACDLKLDDVL--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-TPSIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKVWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQQQ-EV---------EKVKPQSEKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLNSEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-IDC----SPHKTVKK-----TASEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTARQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLLKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGNVTGT-TEISSDGGLEKD----NSELGSETRYP
LLL--PKGVVLKLKPVANRFPRRAWRQRRSSVLKPLLIQP-SPSLQPSF-NPG-------
KITAQSTHSEAPPSNMVVRIPHLIQPATVLQTVPGVPPLGV----SGGDGFESPA-ALPA
MP--PEARTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LAPSKFRKPYVRR
RPSKRRG-AKASPCMKPAPVIH-PAPVIFTVPATTVKIVSLGSGCNMIQPVNAAVAQSPQ
TIPITTLLVNPTSFPCPLNQPLVASSVSPLIVSGNSVNLP-IPSTSEDK-AQVNVDIACA
VADGKNAFQGLEPKLEPQEVSPLGATVF--PKVEHSPGPPPAET----------------
---ECQEGLSENSAYRWTIVKT--EEGRHT----LEPLPQGIQESLNN-------SN--P
GVSEEIVKMEPEDSGEKIS----GSPE----HDICDDIKEE--HAVELDTGTPSEE----
LSSARKVNKQTVLQKEEERSQPTKTPLSSQ------EPPDEGISGTDVSKGSS-KNASSS
MD-PEVMLSSPPGKLEDSSSVDGQSVGTPVGPEIGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEVESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AVGDSAEKPPSTSASSE--TAPEVETSRTLP-------GENI
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
RILLQEWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEETPKIPTASKNKRRKEIGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRNCSHCG-SK------VCDGKSYKSKELHELVGSSPHREASPMP
GAKDAGQSKDVMEEEVPEERESTEATQSR-TVRTTRKGEMPVSAGLAVGGTLPSPR----
--------------------EVTITERL-LDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEVLPCPKASP------RLQR------ERDGQK-AVGESEASMLVWDASETEKL----
-------------PGTVEPPASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRARVKT--RDRTSPVHESPSG-------TDTSE---T
SPKAPQGG-----LAKDSGTQGKGPE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFGIISQQLGNKTPTE-----------LFHTACEASSEDEDDA
TSTSNADQLSDHGDLLSEEELDE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------QTDGEKERL
GQF--VPL-EEQDGEDIERRKRRRKANKRKREGKSHEEERSLSCDIKLDD----------
-----TLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETEDIPLFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEVK-PPQFVDIPLE--EDDSSDEEY
QPDDEDEDETAEESLLESDVESTASSPRGA-----KR----SRTRRSSDEEGGALCEVEK
VP-TPVVRHISAEVVPMGPPPPPKPKQSKDSTFMEKLHAVDEELASSPVCM---------
---------------DSYQPLE---------DSLIAFRTRSKRPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEEWKRWLGGLMNDDVENEDELDDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDE--
----GPEDEDNVT---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KEQLEQLRMKKSSIKPPQ-ET---------EKSKPQSEKPLQSLVLDCAQRKRLQQQMQQ
KHVQLLTQIHLLASSNPALSSEASTTKMFLSELGNFAQSSTLLRQSFYPKFQTMFQPCNL
KGALQLVEDFHAQVQ-VDC----SPRKAAKK-----SANDFPCLPKQVAWILATRRVFMY
PEL-LPVCSLKANPPRDKIIFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLPTKTAHQL
--------TVRIKNLNMNRAPDNIIRHYKKTKQLPVLFKCCDEIQPNEWKPPVEREEHRL
PFWLKASLPSIQGE-LKQLAEDAREVPGSTGE-ESDLL--GTEKE----SSDTECGEKYP
LLM--PKGLVLTLKPLANRFSRRAWRRQKSSALKPVLIRP-SPCLQPGS-NTV----NIQ
K-TVKLSQSEAPPGKVMVQIPQLIQPATVVQTVPGVQPLNVPAVVGSGDGLEFQN-VLSA
SHP--DSRQGFSGA-------VPPALVSSNPVTFQP----KLMLPD-LAGTKIRKPCVRK
GYQKKKG-TKAAPLIKAPPLI-QPSPVILTVPATTVKVVNIGNGCNMIQSINTAVGRGTQ
AIPVTTLLVNPSTFPCPLNQPLVTSSIPSLIVSPNPVGLS-ASSV-GESEEQLNLIPSCT
AGNNKNSCPVVEPKAEPQELCVPCSAAS--PKKDCSANPTASNNGSQEKVNKSD------
-------------CCSWTVVKA--EENGS-EPLSV-DLLPRLED----------------
--ADKTVKTEAEDSNDAVK---EVNPVQ-KRNLLCAEVKEE--FMLGLGQELNMEAACSC
VNELKEIKKEHALCE--EKG-EEERRALQSSPRDEAQREAGAVGGAQASSESP-KNHSST
ADIET-EFSSPLGRPEDSSSMDGQSVGTPAGPEAGGEREGQEEEEDDDFDDFTQDED--E
EMSSASEESILSVPELQETMEKLTWLATERR-LSQEGDSEEENSQEENSEPEEEEEEE--
GEGIESSQKDD-EV----------------------------------------------
-------------------CGDVSEEPKSAFTLTS--MAPQVEAHRMPPGE-------NM
KAP----GKSRS--SHR-----A-------------RNKRG-RARASKDTSKLLLLYDEN
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLRVIYEFEISMDKQTAVDLYFTL
QKLLHDWPQLLTDFAAFL LPEQALECGLFEEQQAFEKSRKFLRQLEICFAEN PAHHQKII
K-VLQSSVDCLPQEIAELKTQMWQLLKGHDHLQDEFSVFFDHLRPSASRMGDFEEINWTE
EKEYEFDGFEEVSLPDVEEEDEPPKIHSAPKNKKRKEIGGQNNDKE-AEWGDGMKECSCS
CHEG-SGELKLKKSKRRSCSHCS-SK------VCENKFYKNKDSQELSASIAQQESSPQP
EGKDSGTSKEPAEE-NLENRDEGEDVQSR-TKTALRKGDPLPAE---------------G
RAACSRHTSPDKAA--LPER---RLQ----EGA-VSAAK---------------------
DSHSFIAAPGWTRMQKAAPKLPQETKGSPRSAGSGSEGLKQQ-Q----------QQG-GV
DASL-----------------------------ETEGLPSD---SSDKFGHS-SKLNARE
FEGPPLALEGK-SEAKQSWITPARKPALGKSCCSPSPSNCALEADKMGCTGSVPEN----
------------RLKVCTASLGQK--EEEQQQQRVTEATVCAKNSKVSSTGEKVVLWTRE
ADRVILTTCQEKGAHLETFQAISQKLGNKTAAEVSH-RFRELMKLFHTSCDGSSEDEEDA
TSTSNADQLSDKDLLLSEEEPDD

------------------------------------------------MLPCKKRRTTLL
SSPQHKDSQ-DETHFDLESTT-NPEPD--QVTDLGTVSLPWGLSHVRTPGLDVQPMQDVG
EHICKEDP-S---ASR-LLAQDPDIAILKAIDVSNTQEINLPSLESSQPCNIHITKGKIQ
GTCMRRGKRTALRPGPAPRDDH-------------PNLKESSP-SAEACEKINNESGKLQ
MQSEE--E-GPLQQL--GCHSARLGMQPKKSSQPAVYASPPEKAARTPPTHQNEDDMEDI
GLF--IPL-EQ-DGEESEKRRRKKKGTKRKRDGRSQ-EEGALAYDLKLDD----------
-----MLDRTLEDGAKQHNLTVVNVRNILHEVITNEHVVAMMKAAISETDDAPVFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPEDEEEDETAEESLLESDVESTASSPRGSKRSRMRQ----SSDMIETNEEVGILSEAEK
II-TPPIRHINAEFVPMGPPPPPKPKQNKDSTFMEKLHAVDEELACSPVCM---------
---------------DSLQPLD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LKAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVENEDEADDDDDPEYNFLEDL-DE
PDTEDFRNDRAV-RITKKE-VNELMEE-----LFEP---------FQDEMGFSTIEDK--
----GPKKEDSVT---------------ESRPSFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQLRMKKSSTKQQP-EA---------ERPKPQSDKAQQTLILDASQRKRLQQQMQ-
QHVQLLTQIYLLSSANPSLSSEANTTKMFLRELGTFAQSSVVLHHQFNPKFQTMFQPCNL
KGAMQLIEDFHSHIH-IDW----SPRKNVKK-----SASEFPCLPKQVAWILATSKVFMY
PEL-LPICSLKAKNPRDKIFFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTAKSAHQL
--------TVRIKNLNINRAPDNIIKYYKKTKQLPILFKCCEDLQPDQWKPPVEREERHL
PFWLKASLPSIQEE-LQHLANDAGESGNSSEV-AEPSSELGLEKG----SLESRNENRYP
LLL--PKGVVLTLKPLAKRFSRRAWRQRRSSVLKPLLIRP-SPSLQPGS-NTG-------
RTPTRITQSEAPPSKVVVRIPRLIQPATVLQSVPGAPPLGV----TGGDSFELPV-ALPP
VAP--ENGTCLPPA-------MSQTLLSPAPAAFQP----KVMLPA-LVTSKPRKTGTKW
GPPKREQ-TKASPLLKAAPIL-RPAPVILTVPATTVKVVSLSNGCNMIQPLGATVAQSPQ
TIPITTLLVSPTSFPCPLNQPLVASSIPPLIVSGNPVSLP-VPPTSEDN-TQVKSDIPCP
LAEGKSTFPATEPKMEPQELSTLCSALS--PKEENSPVPPTPSKAT--------------
----SQEGS-------------------------------------------------LE
GDLVEIVKVEPEDPGEEVKLPRNKSPE----QNICGEIKEE--VSVELDTGPAGEG----
ANSTQEVKKEAILQEEE-RGETAEISSIPH------ETQGEGSTKGEVSKGSP-KNNSSP
TNP-A-ALSSPLGKPEDSSSVDGQSVGTPAGPEAGGEKDGPEEEEEEDFDDLTQDEED-E
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGDSEEENSQEENSEPEEEEEEE-V
SEGMENLQKED-EM----------------------------------------------
-----MDE----------TAGGPTEKPPSTFASPK--VTPEVETSRIPSGE-------ST
KAV----GKARG--SHR-----T-------------RSKRG-RTRASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALCHVPGKYEDFLRVIYEFESSTQKRTAVDLYNSL
QTLLHEWPQLLKDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHH QKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPVASRLGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEHPKMSTASKNKRRKEIGGQNHDKE-TEWPDGPKDCVCS
CHEG-NPDPKLKKNRRRGCSHCSSSK------VCDNKVYKNKEPHELLGASPPPEASLTP
ESKEAGRGRETGDE------EALDERDSR-ASRAARKGEMPI-PGLEMGSTLLPPG----
--------------------EGNPTDRAPLDVP-APCSPESPQRSPKAGLV-PNSIRSQA
EAEGVHSPPPKLQ------TLSE-------AQQARATSDSG-------------KT----
-------------SAASGCPAFSLSPVPSNT--KDIG-----------------------
--KGQAPGQAK-PDTQNSWLHPGRKFDRIPTASRIPTVLESP------PPVTTTSG---A
THRVPVGGSS----KEESSQHIR--VPDGEQQLKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSTISQQLGNKTPGEVSH-RFRELMQLFHTACEGSSEDEDDA
TSTSNTDQLSDRGDLLSEEEPDE

------------------------------------------------MLPCKKRRTTVT
ENSQDKSSQ-EEDDLDQESAV-KPESA--EITDLGSVPLSWSPSCGKAVGVEVQSVQNAG
NQPGVEASSL---SSR-ILTQDTNLPSVETGDETVSQGITLSSLESSHSPNVHVGKGKLQ
ATASRRGKKVVLRPGLVTQEDRG----------ELPIMKKPFS--GEPSEEVREEGEGLS
----------PSWHLPF-------------SWQPARCSAPHTSS----------------
------WH-GCQNNEENEKKRKKKKGTKRKREGRDQ-EQGTLTCDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGVLLEAEK
VT-APAIRHISAEVVPMGPPPPPKPKQTRDSAFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRAV
KELLEQLKMKKSSAKQQQ-DM---------EKLKPQAEKVHQTLILDAAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTKIFLKELGTFAQSSTALHHQSNPTFQTLFQPCNL
MGAMQLIEDFSTHIS-IDW----SPPKPVRK-----NVYEFSCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKLIFT-KAEDNLLALGLKHFEGTELPKPLISKYLLTCKTAHQL
--------TVRIKNLNQNRAPDNIIKFYKKTKQLPVLLKCCEEVQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LRHIADSAKEVGNVTGT-TEISADQGLEKA----RSELGSETRYP
LLL--PKGVVLKLKPAANRFPRKTWRQKRSSV----------------------------
-----------PPSKMVIRIPQLIQPATVLQTLPRVPPLGV----SGDDSFESPA-ALSA
VP--PEVRTSFALS-------ESQTLL-SAP---VP----KVMLPS-LGPSRFRKPCVRR
KPSRRKG-AKTFPCPKPAPLIH-SAPVIFTVPATTVKVVSLGSGCNMIQPVNAAVAPSPQ
TIPITTLLVNPTSFPCPLSQSIVASSIPPLIVSGNSVNLS-VSSTPEDK-AQVNVDIGCP
LTEGKNAFQSLEPKLEPQEVTPLCAPVF--PKEEHGPKPLANSR----------------
---ESQVGLSENSAGGQTIVET--EEGRQG----LEPLPQHFQGFVNS-------S---P
GDLKEGVKMEPEDPGEVIS---SGSPG----QHICDEIKKE--QFVELDTGSPWEE----
LSTARVLKRLAVLQKE-EKSQPAHTSSASQ------EPSHEGNAVGDVSKGSP-RTASSS
ME-SEMVMSSPLGKPEETPS-AIQSVETPAAPDVGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----MDD----------SVGDTAEKPPSTLVSPK--TAPEVETCRIPPG-------ESI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSSQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCSECVPHEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRLGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKSKRRKEVGVQNHDKE-TEWPDGAKDCTCS
CHEG-GPDSKLKK-KRRNCSHCS-GS-----KVCDSKPYKHKEPQESVSSSPHGEASPVR
GAKEPGQGKELVEEEALEERESTEALQSR-TGRATRKGEVPA----QVQSMLLSSQ----
--------------------EVPLTERLPEGI--PHPKPEPPLHPPAAAV----LLTRGQ
AGPEALSTDAS--P-----GHE-------KGAGCK-AVGDSEASLLAWDGSQPETL----
-------------PGTVEPSAPL-SPASLGT--SIIAGRHV-------------------
--------TGK-PDAQDTWLSLSSTGARRA--NRSPPGHQPSLG-------SDPSE---V
APEVLRGS-----LAKDGGLQVRGAE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSSISQQLGNKTPAEVSH-RFRELMKLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTLT
DSPQHQGNQ-EEDDLDLESAV-KPELD--HVKDLESVSLSWVPSHGRAAGLEVQSVQDAG
EQLGVEDPPS---DSR-VLTQDTNAPVLEAVDLAISQGITLPSLESSQPLNIHIGKGKLQ
ATSSRRGKKIILRPGPFTQEDRD----------DHPITKEPLS--GEPSEEVKEEGGKPH
VYSEG--E-MPSLSS--GSHSTKPAAQPRKSSQPDVCASPQEKPLRT-LAHQTEEETEDG
GLF--IPM-EEQDSEENEKRRKKKKGTKRKRDGRGQ-EEGTLACDLKLDD----------
-----VLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGILSEAEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLDDL-DE
PDTEDFRTDGAV-RITKKE-VNELMEE-----LFET---------FQDEMGFSNMEDD--
----GLEEE-ECA---------------EPRPNFN-TPQAL--RFEEPLANLLNEQHRTV
KELLEQPKMKKSSAKQQQEVV---------DRVKPQSEKVHQTLILDPAQRRRLQQQMQ-
QHVQLLTQIHLLATSNPSLSSEASTTKIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAMQLIEDFNTHVS-VDW----SPRKTVKK-----TAYEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKSFFT-KAEDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-XXXXXXXXXXXX----XXXXXXXXXXX
XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXX-------
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXX-XXXX
XXXXXXXXXXXXXX-------XXXX-XXXXX---XX----XXXXXX-XXXXXXXXXXXXX
XXXXXXX-XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXX---
-XXXXXXX----XXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--XXXXXX----XXXXXXXXXXXXX----------XXX
XXXXXXXXXXXXXXXXXXX---XXXXX----XXXXXXXXXX--XXXXXXXXXXX------
-XXXXXXXXXXXXXXXXXXXX--XXXXXXX-----------XXXXXXXXXXXX-XXXXXX
XXXXX-XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXXXXXXXXETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----TDE----------AIEDPAEKPPTTFASPK--TAPEVETSRTPPGE-------SV
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHSPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLL-DFAAFLLPEQALACGLFEEH-PFEKSRKFLRQLEIAXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXLKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXXXXXXXX-XXX-XX------VCDSKSYKSKEPHELVGGSPHREASPMP
GAKEAGQGKDVMEEEAPEERESTEATQSR-TGRSTRKGETPIPAGLAAGSTLLSPQ----
--------------------EVTLTDRLPVDGP-PPCSPETPQLPSNAGTV-LGTVRNNQ
AGPEVLPCPRASP------RLQN------EVEGHQAGGESEV-PMLGWDASEAEKV----
-------------PETVEPPASFPSPVSSRT--KDLG-----------------------
--RRQ--VSGK-PDTQESWLPSSRAGVK--TADRVSPVHEPS------SSGIETSE---T
SPKASRGG-L----AKPSGIQGKGPV--GEQQPKATEATVCANNSKVSSTGEKVVLWTEA
DRV---------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRTTVT
ESPQHQGSQ-EEDDLDLESAV-KPASD--QIKDLGSVSPSWGPNHGRAAGLEVQSVQDAG
NQLDMEDPSS---SSR-VLTQDANAPLLEAVDVAASQGVTLPSLDTSQPLNVHIGRGKLQ
ATGSKRGKKVTLRPGPVTQEDRG----------DHPVTKEPFS--GELSEEVEEEGGKMH
ISTS---GSSYSLTA--GASGAGPVAQRRKLLATDVSAGPRKKVLHT-LLRQPTDSGHVL
G-----LFAEEQDNEESEKRRKKKKGTKRKRDGRGQ-EEGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESSILSEAEK
VT-TPAVRHISAEVVPMGPPPPPKPKQTKDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQVL--RFEEPLANLLNEQHRTV
KELLEQVKMKKSSAKQQQ-EV---------ERVKPQSEKVQQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATSNPNLNSEASTTRIFLKELGTFAQSSIALHHQFNPKFQTLFQPCNL
MGAVQLIEDFNTHVS-IDW----SPRKTVKK-----TAYEFPCLPKQVAWILATNKVFMY
PEL-LPVCSLKAKNPQDKILFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAYQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPILGKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-LRHIADGAREVGNVTGT-TEINSDPGLGKG----SSELGSETPYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSVLKPLLIRP-SPSLQPSS-NSG-------
KTPARSTQSEAPPSKMVVRIPHMIQPATVLQTVPGVPPLGV----TGGDNFECPA-ALPA
MP--LETRPSFPLS-------E----LSSAP---VP----KVMLPS-LAPSKFRKPCVKR
RTSKRKG-AKASLCLKPAPLIH-PAPVIFTVPATTVKVVSLGTGCNMIQPVNATVAQSSQ
TIPITTLLVNPTSFSCPLNQPLVASSIPPLIVSGNSVNLP-VPSTPEDK-VQVNVDIGCP
LAEGKNAFQSLEPKLEPQELSPLCATVF--PKEEHSPGPPPLGR----------------
---VCQEDLSENNAYGWTIVKT--EEGRQA----LDPLPQGFQESLNS-------P---P
GDLEEIVKMEPKDPGEEIS---SGSPK----QDVYDEIKEE--HSVELDPG-PSEE----
LSGAREVKKQTVLQK-EERSQPAKTLSASQ------EPPDEGHSG-DVSRGSP-KNVSSS
TD-PELVLSSPPGKPEDLSSVDGQSVGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGIESLQKED-EI----------------------------------------------
-----TDE----------AIGDRAEKPPTTFASPK--TVPEVETSRTPPA-------ESI
KAA----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
KILLQDWPQLLKDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPS HHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-AEWPDGAKDCACS
CHEG-GSDSKLKKSKRRNCSHCS-SK------VCDSKSFKSKEPHELVGSSPHREASPMP
GAKEAGQGKDVMEEEAPEERESLEATQSR-TGRSTRKGEMPVP-GLAVGSNLLS-Q----
--------------------EVTLTDRLPLDGP-SPYSPETPQRPSKTGAV-LYTVRRSQ
AGPEAVSCPKASP------RLQN------EGEGHK-AVSESEASMLAWDASETEKL----
-------------PGTVQPPASFPSPISSVN--KDLERRQV-------------------
--------SGT-PDTQESWLPSNRAGVKTA-DRLSPVRESSSSG-------IDTSE---T
SLKAARGG-----LTKDSGIQGKGPV--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSIISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------LKDVPI----GQLEAK
LKAPDITPDMYEQN----TADDDEWKKWLRSLMEDDMGNEDEGDDEDDPEYNILEDL-DE
PDTEDLRNDRAV-RITKKE-VSQLMEE-----LFET--------SPRRQMGFSHVEEE--
----GPDEDS-NQ---------------EALPNFN-TPQAI--RFEEPLANLLNEQHRTV
KAQLESLRLRKSLMKPQC-QGADESTPAPEEPKAPPPAKAAPVMFLDETQRRRLQQQMQ-
QHVQLLTQMHLLTCQNHQLSQQADLSRMFLSELEVPGPSPWGIAPLYPPPPPLLLTPCWC
LLSPSHPSDTLLPSD-PPCWALLSPSHPSDP-----PAGVFFLLPILLTLLLG--SLLSF
PPC-WGL--LSPSHPSDPPCWGLCLSCSLLALGLKHFEGTDYYKPLISKYLVTGKSAQQL
--------TVRIKNLTMKKTPENIIKFYKRTKLLPVMLKFCDDAQSPGAKAPVEREKHRL
PFWLKSNKQPFYAHAVGHRVPGSQVGYHFIPV-I-LSGQANLSSIEEEFGKYKKGAQTYP
LT--PPPGLQLNMKPLPQRFLHRSWRQKRSSILKPLLIRP-TSNIGTNC-PFP-------
KTVAKMPSPDPFPIGLYARVSSLVQPQPAVQGLVGIHPADV----PAGGK----------
---SQEVRATLPFA-------ARPSRLHPPPVAPVPIAPAKVLQPA-MLNQRA--RRLLG
GMTRRRT-AVRNPAIKAAPLV-HSAPVIFAVPSATLKLVSLGSPCGVIQPISSR-----G
GVPVTTLLLNPPPVPVS--QTLVPSALSQT-----PRAE------PERL-V------GGD
TTEGQVQSEGGTTFKE--EDEWDCVSITIKVKEEGGLVP-GGH----------TDCGGEG
--------TS---A--ASHIKK------ER----VSPFRPGEKPPQKE----NCPFYLTE
VPLEPGSEYDPPECEQR----------------GGAQ-------TCESGSGLCEQQ----
GSSAGQRHRDHTLGKEPDE--KEETEDVAM------EEEDGGNETQNPDAAESPKNTSSS
TDGDV-DISSPAGTPLDSSSPS-------GRPESANDKDGPEEEEEEDFDDLTQDEDE-E
EISSASEESVLSVPELQETMEKLTWLASERR-LSQEGDSEENSQEENGDEGIEPSSQK--
EEEMTD------------------------------------------------------
-------EVAEGGTESAQSHLCPTL---------P--MPVET--RAVPAGERR-------
R------GSSRGPGSHR-------------------VRSRRGRARTSKDASKLLLLYDEN
ILAKDPLREQKDMAFAQCYLTRVREALQYAPGRYEEFLQLIYQFESSRRERTAVDLYERL
RGLLRDWPQLLRDFAAFL LPEEALECGLFEEQQAFDKSRKFLRQLEICFMEN PAQHQKII
K-LLQSCAECPLQEITKLKAQMWQLLRGHNHLQDEFSMFF DQLRPPASRLGEFEVMTWTE
DKEYKFDGYEEVTLPDVEEEEESGKVAAPRTK-R-----KKDQDKE-GEWQ----ECSCL
CHEG-ATEPRLKRSKRRICTQCS-TK------VCDSRAQRARDPPEVMAGGLPRSLRQGP
TMKEVGKCNHG--------------------------NMLPSWSSVTNCSCLSAPG----
--------------------EGAL-PPRDT--Q-DRLSAELPVG--QRGSSDTSGSNSNM
AGAQRARGSTHSRA------P--------------SVPGSTSLGKPR-------------
-------------PGTRDSPRT-PAPP---H--PRSSRRPL-------------------
--------CMKDPDQPPNKLLPSST--AP-PRELNPPVPSVSEQ-------SLASIILCS
TPSAG------------PGTDPLDPNSKESPDPDEQTSTVCAKNITVSSSGEKVILWTRE
ADRVILTMCQERGAQPDTFADISQSL GNKSADEVSR-RFQDLVSLFQTACVTSSDEEEEA
GSTAE---------LLSDQEVED

------------------------------------------------MLPCKKRRTTVT
ESLQHQDIP-EGENLDLESAVTV-ESG--QAKDLESLSLCWGPSHGA-ADLEVQ-SQDAG
NQLGMETPSS---GCG-VLTQDPNVPILEAVDVAISQEITVSSSESPQPINIHIGKEKLQ
ITDLKRGKKITVRPELVTQEDSG----------NHTITEEPFS--GELSDEIKKEGXXXX
XXXXX--X-XXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
XXX--XXX-XEQDNEQNEKRHKKKRGTKRKRDGRGQ-EEGTLTHDLKLDD----------
-----MLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVIAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISSIK-KAIEIK-PPQFVDIQLE--EDDSSDEEY
QPDDEEEDETAEEXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXVEK
IT-TPATRHLSVEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELDSSPVCM---------
---------------DSFQTMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYGPN----TADDEDWKMWLGGLTNDDVGNEXXXXXXXXXXXXXXXXX-XX
XXXXXXXXXXXX-XXXXXX-XXXXXXX-----XXXX---------XXXXXXXXXXXXX--
----XXXXXXXXX---------------XXXXXXX-XXXXX--XFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQREKVQQTLILDAAQRKRLQQQMQ-
QHVQLLTQIHLLATANPSLGSEATTTRIFLKELGTFAQSSIALHHHFNSKFQTLFQPCNL
MGAMQLIEDFNTHVS-IER----SPRKTVKK-----TASEFPCLPKQVAWILATNKVFMY
PEL-LPVCSLRAKNPQEKILFT-KAEDNLLALGLKHFEGTDLPKPLISKYLLTCKTAHQL
--------TVRIKNLSMNKAPNNIIKFYKKTKQLPILVKCCEEIQPHQWKPPVEREEHQL
PFWLKASLPSIREE-LQHIADGAREVGGMAAT-AGINSDPGLEKG----SXXXXXXXXXX
XXX--XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX-XXXXXXXX-XXX----XXX
X-XXXXXXXXXXXXXXXXXXXQLIQPAPVLQTMAEVPPLGS----TGNDGFESLT-ALPA
LPP--EARTSFPLS-------ESQTLLSPA---PLP----KVLLPS-LAPSKFRKPCVKR
KGSKRKG-PKAAVCLKAAPVI-HTAPVIFTVPATTVKVVSLGSGCNMIQPVSAAVAQTSQ
TIPLTTLLVNPASFPCPLNQPFVASSIPPLIVSGNSVNLP-VSSTPEDKTQVNVDSVGCP
LAEGNSAFQGLQPKLEPQELVPVCATVF--PKEERSPVPAAAERGCQEVLPESN------
-------------VYGWTIVKT--EERRQ-ALE---ALPPGLQDSLS----------SPQ
EDLKVIVKMEPKDPGEEIS---SGFPE----QDMGGEIKEE--HSVELDTGFPSEE----
SGGAREVKKQTVLLTEVEKGQPARTHSVS-------QE-PEDGNSGEVSKGSP-QNASFS
TDPEL-VLSSPPGRPEDSSSMDGQSMGTPAGPEPGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEEE--
TEGVENLQKED-EM----------------------------------------------
-----TDE----------AVGDPAEKPPTPYASPK--TAPEVETSSTPPGE-------NV
KVA----GKGRS--SHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHVPGKYEDFLQIIYEFESSTQRQTAVDLYKSL
RSLLQDWPQLVKDFAAFLLPEQALACGL--------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------MLPCKKRRTTL-
ESPQHQGNQ-EEDDLDLQSAV-KPESD--QVKDLGSVSLSWSPSHGRAADLEV---QDAG
IQLGMEDPSL---SSR-MLTEDTNVAVLEAVDVAISQGLTLPSLESSQPVNTHLGKGKLQ
ATSSRRGKKITLRPGSATQEDRG----------NHPIAKESFS--EDPSEEVKEEGGKSQ
MHSE---GEMPSLPS--DSHSAKPAAPPRKSSQPDVCASPQEKPLRT-LAQQAEEETEDG
GLFI--PM-EEHDSEENEKRRKKKKGTKRKRDGRDQ-EERTLSCDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--DDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEAEK
VT-APAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TSRAL--WFEEPLANLLNEQHRTV
KELLEQLKMKKSSAKQQQ-EV---------ERVKPQREKVHQTLILDPAQRKRLQQQMQ-
QDVQLLTQIHLLASSNPSLSLEARTTRILLKELGTFAQSSIALHHQFNSKFQTLFQPCNL
MGAMKLIEDFSTHVS-VDW----SPRKTVKK-----TACKLPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIFFT-KAEDNLLALGLKHFEGTEFPKPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLMKCCEEIQPHQWKPPVEREEHRL
PFWLKASLPSIQEE-MRHIADGAREVGNVTGT-TEINSDPGLGKG----SSELESETRYP
LLL--PKGVVLKLKPVANRFSRKAWRQKRSSTLKPFFFGP-SPSLQPSC-SSG-------
KTPARSAHSEAPPSKMVVRIPPLIQPATVLQAVPGGPPLGV----PGRDSFESPA-ALPA
TA--AEARTSFPLP-------EPQTLLSSAP---VP----KLMLPS-LAPSKFRKPCVKR
RASKRKG-PKASLCLKPAPLIR-PAPVFFTVPATTVKVVSLGGGCSMVQPVSAAVAQSPQ
TIPITTLLVNPAPFPCSLNQPLVASSIPPLIVSGTSVNLS-VPSTPEDK-APVNVDIGCP
LTEGKNAFQGLEPKLEPREPSPLCAAVF--PKEEHSPGPPATDR----------------
---VCQEQLSESSAYGWTVMKT--EEGRQA----PEPLPQGLRESLNT--------C--P
EDLEEIVKMEPKDPGDDTC---GGSLE----QDSHDEIKEE--RSVELDTGFPSEE----
PGRPREGKKQTGLQQEEERSQAAQTLSASQ------EPPGEGNSG-DVSKESP-RDASFS
TD-PEMVLSSPLGKPEDLSSVDGQSVGTPAGPEAAGEKEGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMENLQKED-EM----------------------------------------------
-----MDE----------AIGDPAEKPPATLDSPK--AAPEVETSRTPPGVS---EGESI
KAA----GKGRS--NHR-----A-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAF LLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPS HHQKII
K-VLQSCADCLPQEITELKTQMWQLLKGHDHLQDEFSVFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEIGVQNHDKE-AEWPDGAKDCACS
CHEG-GPDSKMKKSKRRSCSRCS-SK------VCDSKSYKSKEPHELVGSSPHREASLTP
GAKEAGQGKDVMEEEAPEERDSTEATQSR-TGRSTRKGEMPVA-GLAAGSTLPSPQ----
--------------------EVTFTDQL-LDGPPPPCSPETPQLPSTAGTV-LCAVRSNQ
AGPAVLSGPRASP------RPQY------EGEGHK-PGAELEP-SMPWDASETEKL----
-------------PGTVEPPASFLSPVSSRT--GDFGRRQV-------------------
--------PGK-ADTQESWLPSSRAGVTTA-DRVSPLRGVSSAG-------IDTAE---T
SPIAPRGG-----LAKDSGLQGKGPA--GELQAKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQEQGAQPQTFSVISQQLGNKTPTEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ENSQDRSSQ-EEDNLEQESAF-KPESD--QVTDLGSVPLSWGPSQGRAVGVEVQSVQNAG
NQPGVEAPSL---SSR-ILTQETNLPSLEGVDEAISQGITLTSLESSHSPNVHISKGKLQ
ATASRRGKKVVLRPGLETQEDRS----------DRPIIKKPFP--GEPSEEVKEEGGKPQ
MHSG---GETPLLPS--GSQSVKPGTQPRKSSQPDVCASPQEKPLRT-LVHRAEEEREDG
GLFI--PM-EEQNNEENEKKKKKKKGTKRKRDGRDQ-EQGTLTCDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDEEEEDETAEESLLESDVESTASSPRGAKKSRLRQ----SSEMTETDEESGILLEAEK
VT-APAVRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQPMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LRAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------ESRPNFN-TPQAL--RFEEPLANLLNEQHRAV
KELLEQLKMKKSSTKQQQ-EM---------EKLKPQAEKVHQTLILDVAQRKRLQQQMQ-
QHVQLLTQIHLLASSNPNLSSEASTTKIFLKELGTFAQSSTALHHQSNPTFQTLFQPCNL
MGAMQLIEDFSTHVS-IDW----SPPKPVRK-----NVYEFSCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKLIFT-KAEDNLLALGLKHFEGTELPKPLISKYLLTCKTAHQL
--------TVRIKNLNQNRAPDNIIKFYKKTKQLPVLLKCCEEVQPHQWKPPIEREEHRL
PFWLKASLPSIQDE-LRHIADSAREVGNVTGT-AEISTDQGLEKA----HSELGSETRYP
LLL--PKGVVLKLKPAANRFPRKTWRQKRSSV----------------------------
-----------PPSKMVIRIPQLIQPATVLQTVPGVPPLGV----SGDDSFESPA-ALAA
VP--PEVRTSFPLS-------ESQTLLSSAP---VP----KVMLPS-LGPSRFRKPCVRR
KPSRRKG-AKTFPCPKPAPLIH-SAPVIFTVPATTVKVVSLGSGCNVIQPVNAAVAPSPQ
TIPITTLLVNPTPFPCPLSQPLVASSIPPLIVSGNSVNLS-VSSTPEDK-AQVNVDIGCP
LAEGKNALQSLEPKLEPQEVTPLCAPVF--PKEEHSPRPLAASR----------------
---ESQVGLSENSTCGRTLVET--EEGRQG----LEPLPQGFQGFLNN-------S---P
GDLKEVVKMEPEDPGEVIC---NVSPE----QHICDEIKKE--W----DTGSPREE----
LSSARVLKKQAVLQKE-ERSQLAHTPSASQ------EPSDEGSAVGDVSKGSP-RNAPSS
VE-PEMVLSSPLGKPEEASSVDGQSVGTPAGPDIGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGVESLQKED-EM----------------------------------------------
-----IDD----------TVGDTVEKPPSTLASPK--TAPEVETLRIPPG-------ENI
KAA----GKGRS--NHR-----T-------------RSKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSSQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCVPHEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRRKEVGVQNHDKE-TEWPDGAKDCACS
CHEG-GPDSKLKKSKRRTCSHCS-GS-----KVCDSKPCKHKEPQESVSSSPHGEASPVR
GAKEAGQGKELVEEEALEDRESTEALQSR-TGRTTRKGEVPAP-GSTVRSMS-VSQ----
--------------------EVPLTERLPEST--PRPTPETPQHPPPTAAA-LHTVQRGQ
AGPEGLSASAS--P-----GHEK------EGDGCK-AVGDSEASLLVWDASQPETS----
-------------PGTVEPSAPFPSPASSRT--RVIGRRHV-------------------
--------PGK-PDAQDTWLSSSRAGARRA--NRLSPSHEPSLG-------VNTSE---T
APEAPRGS-----LAKDGGVQVRGSE--GEQQPKATEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSSISQQLGNKTPAEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDE

------------------------------------------------MLPCKKRRTTVT
ESLQHKGNQ-EENNVDLESAV-KPESD--QVKDLRSVSLSWDPSHGRVAGFEVQSVQDAG
NQLGMEDTSL---SSG-MLTQDTNVPILESVDVAISQGITLPSLESFHPLNIHIGKGKLQ
ATGSKRGKKITLRPGPVTQEDRR----------DHPILKEPFS--EEPSEEVKEEGGKPQ
MHSE---GEIPSLPS--GSQSAKPVSQPRKSTQPDVCASPQEKPLRT-LFHQPEEEIEDG
GLFI--PM-EEQDNEESEKRRKKKKGTKRKRDGRGQ--EGTLAYDLKLDDML--------
-------DRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISESEDMPMFE----
----PKMTRSKLKEVVEKGVVIPTWNISPIK-KANEIK-PPQFVDIHLE--EDDSSDEEY
QPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQ---SS-EMTETDEESGILSEVEK
VT-TPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCM---------
---------------DSFQSMD---------DSLIAFRTRSKMPLKDVPL----GQLEAE
LQAPDITPDMYDPN----TADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITKKE-VNELMEE-----LFE---------TFQDEMGFSNMEDD--
----GPEEEERVA---------------EPRPNFN-TPQTL--RFEEPLANLLNEQHRTV
KELFEQLKMKKSSAKQLQ-EV---------EKVKPQSKKVHQTLILDPAQRKRLQQQMQ-
QHVQLLTQIHLLATCNPNLSPEASTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNL
MGAMQLIEDFSTHVS-IDC----SPHKTVKK-----TANEFPCLPKQVAWILATSKVFMY
PEL-LPVCSLKAKNPQDKIVFT-KAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQL
--------TVRIKNLNMNRAPDNIIKFYKKTKQLPVLVKCCEEIQPHQWKPPIEREEHRL
PFWLKASLPSIQEE-LRHMADGAREVGHVTGT-TEINSDHGLEKD----NSELESESRYP
LLL--PKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQP-SPSLQPSF-NPG-------
KTPARSTHSEAPPSKMVLRIPHLIQPATVLQTVPGVPPLGV----SGGESFESPA-ALPA
MP--PE------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------A
VANGENAFQGLEPKLEPQELSPLSATVF--PKVEHSPGPPSADT----------------
---ECQEGLSENSACRWTVVKT--EEGRQA----LEPLPQGIQESLNN-------SS--P
GDLEEVVKVEPEDAREEIS----GSPE----HDICDDIKEE--HAVELDTGVTSEE----
LNSAREVKKQTVLQKEEERSQPAKTPSSSQ------EHPDEGTSGTDVNKGSS-KNALSS
VD-PEVRLSSPPGKPEEPPSVDGQSVETPVGPETGGEKNGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGESEEENSQEENSEPEEEEEE--E
AEGMESLQKED-EM----------------------------------------------
-----MDE----------AVGDSAEKPPSTFASSE--TAPEVETSRTPPG-------ESI
KAA----GKGRN--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
QILLQDWPQLLKDFAAFLLPEQALACGL--------------------------------
------------------------------------------------------------
---------------------------------------------E-TEWPDGTKDCACS
CHEG-GPDSKLKKSKRRSCSHCS-SK------VCDSKSYKSKEPHELVGSSPHREASPMP
GTKEAGQGKDVTEEEAPEERESTEATQSR-TVRTTRKGEMPVSAGLPVGATLPSPR----
--------------------EVTLTKQLLLDGP-PPHSPETPQFPPKTGAV-LYTVKRNQ
VGPEALSCPKASP------RLQK------EREGQK-AVGESEALMLVWDASETEQL----
-------------PGTVEPHASFLSPVSSKT--RDAGRRHV-------------------
--------SGK-PDTQERWLPSSRGRVKT--RDRTSPVHESPSG-------IDTSE---T
SPKAPRGG-----LSKDSGTQG--------------------------------------
------------------------------------------------------------
-----------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------SEDIKEGGKPQ
MPPEG--E-MPSLPP--GSHPAKPGVQPRKSSQPGVCAS-QETPPKA-VAHQAEEEVEDG
GLF--IPM-EDQDGEESEKRRKKKKGTKRKRDGRSQ-EEGTLSDDLKLDD----------
-----VLDRTLEDGAKQHNLTAVNVRNILHXXXXXXXXXXXXXXXXXXXXXXXXXX----
----XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-XXXXXXXXXX--XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXX
XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------
---------------XXXXXXX---------XXXXXXXXXXXXXXXXXXX----XXXXXX
XXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXXXXXXXEADDDDDPEYNFLEDL-DE
PDTEDFRTDRAV-RITXXX-XXXXXXX-----XXXX---------XXXXXXXXXXXXX--
----XXXXXXXXX---------------XXXXXXX-XXXXX--XXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXX----XXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
--------XXXXXXXXXXXXXXXXXXLYKKTKQLPVLVKCCEEVQPHQWKPPVEREEHRL
PFWLKXXXXXXXXX-XXXXXXXXXXXXXXXXX-XXXXXXXXXXXX----XXXXXXXXXXX
LLL--PKGVVLKLKPVAKRF-RKAWRQKRSSGLKPLLIRP-SPSLQPSF-SSG-------
KTPARSTQSETPPSKTVDQFPHPTQT------VSGVPALEV----SGGHGCDSSV-ALP-
-----EARTGFP---------------SSAP---VP----KVMLPS-LAPSKFRKPCVKR
RPPKRKG-TKASPCVKPAPFI-HPAPVIFTVPATTVKVVSLSTGCNVIQPVNAAVAQSPQ
TIPIATLLVNPTSFPCPLNQPLVASSIPPLIVAGNSVNLH-VPPAPEDK-AQGSVDLVRP
LAEGKGAIQGLEPKVEPQESSLLGPPVL--PKEEQSPGPLQADRGCPEELSENC------
-------------AYHWTIVKT--EEVGKA----LEAVPPDLQE--------------SP
GNLEEVVKVEPEEPGDEIS---KGSPV----QDVCGEIKEE--PSVESDTNSPIEG----
SSGAREVRKQTALQKEEGKSQPTKAPSASQ------EPHDEGNLGGDVNKGSP-ETSLSS
ADPEM-VLSSPLGKPEDSSSIDGQSVGTPAGPETGGEKDGPEEEEEEDFDDLTQDEE--D
EMSSASEESVLSVPELQXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXXXXXXXXX-EM----------------------------------------------
-----TDE----------APGDTAEKPPSTCNSPK--TVPEVETRKTPPGE-------SV
KAT----GKGRS--NHR-----A-------------RNKRGSRARASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRQTAVDLYKSL
RALLQDWPQLLKDFAAFL LPEQALACGLFEEQQAFEKSRKFLRQLEICFAEN PSHHQKII
K-VLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEPPKIPSASKNKRRKEIGVE------TEWPDGTKDCACS
CHDG-GPDSKLKKSKRRNCSHCS-SK------VCDSKS-KSKEAHELVSSSPHREASPMP
GAKDTGQGKDAVEEEAPEERESTEATLSR-TGRATRKGEMPVPAGLAVENTLLTPR----
--------------------EVTFTDRHLLDGP-LPCSPETPQPSPQT-------VTRHQ
AGPEVSFNSKASL------ELHK------DREGCKAVGEPET-SRLVRDAPETEKL----
-------------PGTVELPTSFMSPVSS-T--TDLG-----------------------
--RKH--ASGK-TDTHESQLPSSRAEVK--TADRMSPVHEXX------XXXXXXXX---X
XXXXXXXX-X----XXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDHGDLLSEEELDD

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------QYYKKTKQLPILFKCCEELQPDQWKPPVEREERHL
PFWLKASLPSIQEE-LRHLANDSGESGNVSEV-AEPNSESGLDKD----SLESKNETRYP
LLL--PKGVVLTLKPLAKRFSRRAWRQRRSSVLKPFLIPP-SPSLQPAP-NTG-------
RTPTRLTPPEAPPSKVVVRIPRLIQPATVLQSVPGPPPIGV----PGGDGFELPI-ALPS
VAP--ENGTCLPQT-------MSQTLLSPAPAAFQP----KVMLPA-LVPSKPRKPGTKR
RPPKRDR-TKPSPLLKATPIL-RPAPVILTVPATTVKVVSLSNGCNMIQPLGAAVAQSPQ
TIPITTLLVSPTSFPCPLNQPLVASSIPPLIVSGNPVNLP-VPPTPEDH-TQVKSDIPCP
PAEGKSTFSAMEPKLEPQELSALCSTLS--PKEEHNPVPPTSGKTT--------------
----SQEDPFEGNSHSWTVVKT--NEGREV----LEPLPQNSWETIT----------FLP
GDLVEIVKVEPEDPGEEVKLPQNKSPE----QNVCGEIKEE--VSVELDTSLSGEG----
ANSTQEVKKEAVLQENE-NSETAEISSVPQ------EIQGEGNTREEVSKGSP-KNISSP
TNP-A-ALSSPIGKPEDSSSVDGQSVGTPAGPETGGEKDGPEEEEEEDFDDFTQDEED-E
EMSSASEESVLSVPELQETMEKLTWLASERR-MSQEGDSEEENSQEENSEPEEEEEEE-V
SEGMENLQKED-EM----------------------------------------------
-----MDE----------TIGGPVEKPPSTFASPK--VIPEVETSRIPSGE-------NT
KAV----GKSRS--SHR-----T-------------RSKRG-RTRASKDTSKLLLLYDED
ILERDPLREQKDLAFAQAYLTRVREALRHVPGKYEDFLRVIYEFESSTQRRTAVDLYNSL
QTLLHDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKII
K-VLQGCADCLPQEIGELKTQMWQLLKGHDHLQDEFSVFFDHLRPVASRLGDFEEINWTE
EKEYEFDGFEEVALPDVEEEEEHPKMSTASKNKRRKEIGGQNHDKE-TEWPDGPKDCVCS
CHEG-NPDPKLKKNRRRGCSHCS-SK------VCENKTCKNKEPHELLGTSPPPEASPTP
DAKEAGRGREPGEE------EALDEQDRV--LRAARKGEGNVPAGLEMGEAVL-PS----
--------------------EGNPTDKAPLDVP-APCSPESPQSSPKAGLV--NSIRRQA
GAEGVYAPYSKLQ------TSSE-------SQQEGAMAGSG-------------K-----
---------------AAGCLTAPPSPLPSNT--TNVG-----------------------
--KGWTSGQGK-PDTPNSWLHPGRKFDNK-TTTRIPTVLESP------SPVTTTSG---A
VHRVSVGGSS----KEDTGLHVR--GSDGEHPLKASEATVCANNSKVSSTGEKVVLWTRE
ADRVILTMCQERGAQPQTFSTISQQLGNKTPGEVSH-RFRELMQLFHTACEASSEDEDDA
TSTSNTDQLSDRGDLLSEEEPDE

Query Results

"ENSGT00390000016256_0"

ENSGT00390000016256_0