Query Results 

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLDHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGDSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFNYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKIS-----------------------E-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDGKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGMDEHLAKASLS---------------NNECGSLGKTSPEMS-NSN-DD
RKKALISSK-KTSTECASSTENSFVVS--NSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT---------ETMIKTDFLPKAKQKEGNFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKKSKPLVR-
------------SEQEKNTEESTESMV-VLEN-NPSGLLNQTECVSDN-QVHPS-ESIME
HDNTKLKAATMENAVLLETNTVEEKTVEINLESKENTPPVVIST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKSDPDNIKSEGD
G-TQDVIDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSEILQVPDDLP-NPC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGTSDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEISETKKAD
VQAPVSTSET-SQANPCSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFH-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEPDIA-KLN-AKEVATEEFNSDISLPDNTTPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDPHSSEETN-TEMKNDEEMKIGEVKAETGHD
GETENEGINTKTS-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNQMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANSIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGDSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFNYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDGKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGMDEHLAKASLS---------------NNECGSLGKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSLSPLNNISSTVT----VKNNQETMIKTDFLPKAKQKEGNFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKKSKPLIR-
------------SEQEKNTEESTESMV-VLEN-NPSGLLNQTECVSDN-QVHPS-ESIME
HDNTKLKAATMENAVLLETNTVEEKTVEINLESKENTPPVVIST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKSDPDNIKSEGD
G-TQDVIDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSEILQVPDDLP-NPC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGTSDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEISETKKAD
VQAPVSTSET-SQANPCSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFH-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEPDIA-KLN-AKEVATEEFNSDISLPDNTTPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDPHSSEETN-TEMKNDEEMKIGEVKAETGHD
GETENEGINTKTS-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNQMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLAPDEERLA-----------------------S
DIIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANSIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAAGRSPLEPLLETWEDPSASP

PF12231 // ENSGT00390000012204_0_Domain_1 (112, 504)

GEQTDAYLT
-----------LTSRMTGQEGKEVIAEIEKNLPRLYTVLKAHISSQNSELSSAALQALGF
CLYNPKITSGLSEANIQQLLLTLNDII-KSSDKNVCTRALWVLSKQTFPTEVISKMV---
--------------------------SSIIDSLEVLLSKGEIHSAVVDFEALNVIIRYNS
WFVHTTVLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTVSVAFVSL----LNSVLVAFTWSLKFS-LKSALHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRAETLALT
KLEVWWYLLIRLGPQLAANFEQVCVPLIQSTISVDSVA-SPQGSSSRGSTSPGLSPLSP-
LTPG--HKGVPATPRMSPSSNIGGMASIPSIQLLGLEMMLHFLLGPEVLNFAKQHKLVLS
LEPLEYPLISSPSFFSKHAHTLITAVHDSFVAVGKDA--SDAVVSAIWKALISLVKSVTE
SGNRKERSGSEVLTLLLKSLENIVKSEVFPVPKTLVLMEITVKELPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVADEKFFLNLETLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLANKEHLWRMWSIIVTPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAKTFPMATMKTLLKTWSELYRAFARCAALVATAEENLCCEELSSKILCSVED
EVLSDLLFLDRISQIIIVMVDCIDFSPYNIKYQPKIKSLQRS-SEWSRKK-KEPLGKLAS
LFKLIVRVIHSFHTLSFKETYSD----TLVNIVNSVISMLSNIFGHISLPSMIREIFATF
TRPLALLYEN-SK--LDEVPKVYSSLNNKLEKLLGEIVACLQHNYPGAYDSELLGQLSPL
LCIIFLHKNKQIRKQSALFWNATFAKSTTLVYPEELKPILREAKQKVLLLLPGLENVEMM
D-ECSGPYSDVTENSQLNVKISGM--ERKSSGKKYSFLARTKDRKE-NTK-------LSA
KLKLESSSPKLRSN-KLLEEEKSTDFVFIPPEEKEAKSRILTEHQKEVLKTKRCDIPALY
N-NLDVSQDTLFSAQF--SQEESMES--HTLTEKPKEDA-----------KEEQMESTVF
--ISQDAMENSGMDVHPEKASLP---------------NDSC-SVAGTNSEALSPD-IDA
TENMLISSK-IVSAECSS-IESSLVAS--SSSVSNA--------TVSGTP-PQPVSRRQT
FITLEKFDGSE--NRPFSPSPLNNMSSTIT----VRNNQENTTKTDMSLKARKREMTHS-
-------------KSDSEKLVNGGKKSG-----RRWGKVE-------QLTNKTSKPSLR-
------------SEQEEHA----------LEN-NPSDLLSQADCVSDN-HNHPS-GATLE
HEDRNPKP-AVENA-LLEAS-TEEKNIGVNTGSKENKLPVPAPA-DQIVNEDSQAA-VAP
NPKTLRRSSRRRSDIVESSTDSQEKDNVQQKKERRKEEEKT-ISKSPLHIKDDKLPKQKL
TAESL--TQENLTEKGNGLHDKTLEEPS----------GNAEVDQNKRKPNQENISSEG-
GGTQDSVDKSSEKPLRGRTRYQTRRASQGLLSSVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-TEEQEEKMVKDECIKKTAN--------------ETHE
VDVET--AAQVFEEST--NRVILQES--IGSSDSLQVTD-PP-VTT----EDTSKTSKCV
GNS-----LAVTHVPESNLRTRNAIKRLRD-------T-----------DSGTSDISVPS
EKWSQAVECQHKRS-RRVRRSKGCDCCGEKSQYQE--KTFIGLKNTESCAMKSMETKTTD
TQVPETTPETCEA-NELAETKLVD-EHPGVSFHLGLKEENG-ASD-LLRSETGLEEDRK-
-NLPY-E-MV--KEN--PHETD-SSETLSEI-------QKSYNEKFN-AEDPCLSDSKDI
SEK-YSLDN-------------------KVEKFDVSDL-----GRVSKV----------I
AGSSSEGV-EAMELDLGN----DTFETAVS-EESA-QMDIS-----------VDMA----
PEED-DK-DEFETV-TTEMN-AEGKAPEGFNSGMSLSDNMTPLSKRT-------------
--------VQT--EHPARAELEGDS-VKSDPGSCEEMN-KEMENYKAP----VITEVDKA
G-EEDRDMIVS-TPAPEEAPIGRLDVKTESFV----CDALDKSSE-----EGTVYYKTET
KVELNQLDE--TKSSDNQTVMGSD--ILQEVCFT--SEKVEEFPRSLTSEVTF-ELVAES
SN-ASPEKLGVLD--PSLGSATESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-HEDE
LSSPVNK--VRRVSFADPIYQAGLADDIDRRCSVARPH-SSNSSPLVKS---AKTSPTSH
SKHNTTSAKGFLSPGSQSSRFKSSKKCLITEMAKEPMLSPTTESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPVFDLSERAVNGVESKPLSTDEERLA-----------------------S
DLVDPVTLDT--PLTKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSDVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--ADVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKCLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDSV
--IPQDVTEDRGMDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKFKAATMENAVLLETNTVEEKNVEINLESKENTPPVVLST-DQLVNEDSLVL-ITP
NQKILRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKKAD
AQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--ACDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATKEFNSDISLSDNTTPVKLN--------------
--------AQTEISDQTAAGEL---NDVSDPQSSEETN-TEMKNDEEMMIGELKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--SDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEIFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGTDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVLST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDIEVSETKKAD
AQAPVSMSET-SQANPYSEGQYLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATEEFNSDISLSDNTTPVKLN--------------
--------AQTEISDQTAAGEL---NDVSDPHSSEETD-TEMKNDEDMMIGEVKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISALITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPTGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTARGQSPLTPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSDVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--ADVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDSV
--IPQDVTEDRGMDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVLST-DQLVNEDSLVL-ITP
NQKILRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKKAD
AQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--ACDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATKEFNSDISLSDNTTPVKLN--------------
--------AQTEISDQTAAGEL---NDVSDPQSSEETN-TEMKNDEEMMIGELKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECNKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTINGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTARGCSPLTPLLETLEDPAASAGEQVDAYLT
-----------LASRLTGEEGKEFIIEIKKQLPRLYNAFKTHICSQNSELNSATLQAMGF
CLYNSQITSGLTEKEMQELLSQLTDIATKSTDKNTRTRALWVMSKQTFPNEIVGKAV---
--------------------------PSIITMLEVVFNKVDVHSMVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPIQMEDEAVRWAKLIIPLVVHSAQKVHLRGATALEMGMPLLLKKQQEV
AAVTEQLMTTKLITELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPVIKKIAFIAWKSLIDNFALNP----DILCSTKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPHLPTNFEQVCVPLIQSTISTDSHT-VPQGTPSRGATNAGLNPVTPN
QKTGSFPFGTPVTPRMNFSLNNSGIAAIPSIQLLGIEMLLHFLLGPDVLGFAKKNKLVLS
LEPLQHPLINSPSFFCKHANILIAAVQDSFVAVGKDA--SDAMIYAIWKDIIGFVKSVIE
SGNKKERQGSEVLTLLLQSLKNIMTADAFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DLLN--------GTPALFLIQLIF-NNNLLECGVADERFFQNLETLVGCVLTGPTSPLAF
SDSVLNVINQNAKDLVNKEHLWRMWSILVNPLTELINQTNEVNQGDALEHNFSAVYSALM
LPIIHIFPAQEFPLPTMKALLRSWSELYRTFARCAALVATAEENLCCDELCLKMMSSLED
NTFANLSFLDRIAHVVLVMVECINFSPYNTKQQPQIKIPQTP-TDWSKKK-KEPLGKLTS
LFKVLLKMMDAFHNVNFKDLHSE----TLLSVGTSIISIISNMLGHVSLPSLIQSIFAIL
TKPLALLYEN-SK--LSDVPKVYNCLNNKLEKLLGEILKCLQFRYNGTYNNELLEQLSPL
LCIIFLHKNKQIRKQSVQFWNDTFAKETLLEYPEELKPVLKQAKQKCLLLLPGFEV-EAI
E-ESDSLYSEGTENSQFVAKVSGL--EIQSREKQDILSLRTKNLKEKDLKSP-----SKM
KL--EFLSPKFK-KDAILEDCSSVDFVFIPPKENETKERILTEHQKEVLRTKRSDIPTLY
N-NLDVSQDSFSCH----TQEETMEN--PSLTEESKEESNVMK-------EE-ENVDE--
----KNNTEDIIVDNSIEK-----------HPEKPSISKHKMQSCHEKNNLLLN-----I
KKHIEKNASKIASKEPSGENTSINESP---LNTSN----------NSVSS--GPVSRRQS
FITLEKFDTSE--SRPFSPSILNTVSAAVS----VSENQENVDIASTSVKIKTKEINISK
PDR--------------EKVMSGTKKTI-----RRSNKTE-------HIGSKRPKLLK--
------------SEEEKNLQESSGS-IMPVEN-KLADPLDHKE---DTEDI-PSPAKVLE
CEEVKFKH-PVESLEIVE-NTTEGNDLGNNLESKENTPPEVIPTTDQISNDDGH-MQVSS
NQKTLRRSSRRRSEIEC-TPDKQDKENSQEKKEKRKEEEKS-VQKKLSQIKDDVSQKQKP
ISEKNMSEQENLSKKTSNLFEKTS--------------EQTNTEVNKLKPEFECIKSNVD
DFQDCSSDKSSQKPLRGRTRYQTRRASQGLLSSIENSESDSSETKEEISNKKRSGKWK--
--------------NKGSN-LE-NENTKGKIANKDCLG-----SETK-NEGKNEGETSSE
LDVEIRLPSQTSDMNNEQNS-TIND--SVVSIDTSEIS-----SDTENTKEEKSKTSTFA
EDS-----VTNSSVPELILRTRNINKKFHK----QDSMDNSAISLCGDVSDTSDMSLLSE
KA-SPSIECLHKRS-RRVRRSKSCDCCGEKSKLQE--KFFTSLKNTDNCDVKMNEPQRLG
LQATECPLETSCLATAFEVKPLKE-S-CTAIVPLLHNKELEALNYSMTVSENELKENSNF
E-D-HPLERENCEIK--TCAIINDETDLV---------QELSDQNNR-IIDSDLP--IDN
SKDNFEQ---KSVPEMSS---AQPV----------T----SLKEEISQHL----------
EIKNAGFGNNMLEIKVKSDSEADIKHETV------TVTETDKFESSADVDVPEAR-----
ME-ID--IAEESAMANRETT-EPEARADNAQAKT--------------------------
------------FTDTK-----------ADIGNAQAIPLDATA------------ETGVL
---------------------ETL---EKMNTAEAEAKA-ESGTPEE--VKADIVDTEEP
K--------------LNQDYVEADDEIFEKIQDT--SEKVEEPSK-IL--VNVSELITE-
ESNVSPQKLRGID----IQSVNDSPSG--V-QTRCMWSPLASPSTSILKRGIKRQ-QDDE
SPSPLNK--VRRVSFADPIYQEGLADDIDRRSPVVRSH-SSHSSSNSSTAKSLKSSPTTQ
SKHNTTPTKGFLSPGSRSPKFKSSKKCLIAEMTKESPQCSN-ESIYPALVNCGAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLSATEIKTLPIRSPKVSNVKKAL-RVYHEQ
QIKSRGLEEITLIEVSEKSLNGMESKPISPDEETFA-----------------------S
DLIEPVS---DGQQTRNLVAQISALALQLNSEDLHNYSGSQLFEMQEKLGSMTNCIMKNL
QSRWRSPPHESST--------------

------------------------------------------------------------
------------------------------------------------------------
--------------RMT

PF12231 // ENSGT00390000012204_0_Domain_1 (138, 504)

GEEGKEVITEIEKNLPRLYTVLKAHISSQNSHLSCAALQALGF
CLYNPKITSGLSEENIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPSENVSKMV---
--------------------------SSIIDSLEVLLSKGEVHSAVVDFEALNVIIS--H
QFLCC-RLIEQAPVKMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGIPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPGNFEQVCVPLIQSTISTDSIA-SPQGSSSRGSASPSLSPLTP-
GHKGASPYGAPATPRMNPSSNIGGMASIPSIQLLGLEMMLHFLLGPEVLNFAKQHKLVLS
LEPLEHPLISSPSFFTKHAHTLITAVHDSFVAVGRDA--SDAVVSTIWKELISLVKSVTE
SGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLVECGVADEKFFLNLETLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLANKEHLWRMWSIIVTPLTEVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQSFPMATMKTLLKTWSELYRAFARCAALVATAEENLCCEELASKIMCSLED
EVLSDLLFLDRISQIIIVMVDCIDFSPYNIKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVKVIHSFHTLSFKEKCTD----ALLTIGNSIISMISNIFGHISLPSMIREIFATF
TKPLALLYEN-SK--LDEVPKVYSSLNSKLEKLLGEIVACLQYNYSGAYDSELLGQLSPL
LCIVFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKTLLLLPGLENVEMM
D-ESSVPYSDATENSQLNVKISGM--ERKSNGKRDSFLTQTKDKKE-NMK-------LSA
KLKLESSSPKLKSS-KLLEEEKSTDFVFIPPEGKEAKARVLTEHQKEVLKTKRCDIPALY
N-NLDVSQDTLFSAQF--SQEESMES--PTLTENPKEDTKIT--------KEEQMESAVF
--TPQGAVENCGMDEHSEKASLP---------------NDRG-SVAETSSEVLSSG-IDA
TKNTLVSSK-IISAEGSSSAESSPVVN--SSSVSNA--------SVSGT--PQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VRNNQENTTKTDMPTKARKREVTHS-
-------------KSDSEKLVNGGKKSG-----RRWSKAE-------QSANKKSKPSLR-
------------SEQEERV----------SEN-NSPDLLSQTECESKN-H-NPS-EAVLE
HEDRTPKQ-IVENA-LLEDSTTEEKNIDIIMESKENTPSVATPA-GQIVNGDSQAA-AAA
NPKTLRRSSRRRSEIIESSTDSQDKDNGQPKKERRKEEEKT-VPKSPLHIKDDKLPKHKV
TAESP--IQENLTEKGGSLHEKTIEEPN----------VNAEIDQNKRKSDHEDVSSEG-
GGTQDNVDKSSEKPLRGRTRYQTRRASQGLLSSVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-IGEQEEKMVQEECVKAANETNDG---------QTVPE
VDVDA--SAQICEEST--NRVLLQKS--TGSSDSLQVTD-TS-DIG----DDSSNTSKCV
DTS-----FASSPVPESNLRTRNASKRLHK-----RDTD--SV--GECSKMETSDISVPS
EKWAQAVECQHKRS-RRVRRSKSCDCCGEKSLSQE--KSFIGLKNTESCAIKSIET-KTD
MQAPETTPETCDANDEHAETKLVD-EQPIMNFYLGLKEENATTGD-LIRSETGLEDDRK-
-NILL-SEIVNTD----------SGEKVSEI-------QEPWNETFN-AEDPCLSDCKDT
SQK-YSSDN-------------------K--EFDISGV-----GNVCKV----------I
DGSNSEGI-EAMELDVGD----DSFGDSFS-EQKSGQLDIS-----------VDTA----
TEEDNKK-DEIEAV-TTEVN-GEGTATEGLNSGMGLSDKAAPVSK-I-------------
--------VQT--EHPARVNLEG-------MGSCEEMN-KEMESYKAAVIAQSKTEIDNT
R-EKDRGTIVS-SSTSEEAQVRRLDVQTESSV----CDTPEK-SS-----EGSFCHKIER
NIELNKLDE--TKLSDNPTGVGND--NMQEVCLT---EKVEELPQSLTSEVAS-ELVAES
NNNGSPEKLRELD--SSFGSANESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-HEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSISSPIIKS---VKTSPTSH
SKHNTTSAKGILSPGSQSSKFKSSKKCLISEMAKESMLSPTTESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPVFDISEKAVNGVESKPLSSDEERLA-----------------------S
DLIDPVTLDT--PLSKNLMTQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KNSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVIV----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITGIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NMK-------PAA
KLKLESSSLKVKGE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEEPMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDCGMAEHLEKSSLS---------------NNECGSLDKTSPEMS-NSNNDE
RKKALISSR-KTSTECASSTENSFVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SEPEKNTEESVEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESTME
HDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
IAEQT--LQENLIEKGSNLHEKTLGETS----------ANAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KATSE
EDVSI--KSPICEKQDESNTVICQDS--TVTSDLLQVPDDLP-NVC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDISSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLIGLKNTENNDVEISETKKAD
VQAPVSPSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIVSETKSKENTM-
-QESLPSGIVNFREE--ICDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------EKPEETP---K-MELSLEN-V-TVEGNACKV-----------
TESNLEKA-KTMELNVGN-------EASFH-GQERTKTGIS-----------EEAA----
IEENK-RNDDSEADTA-KLN-AKEVATEEFNSDISLSDNTTPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDLHSSEETN-TKMKNNEEMMIGEAMAETGHD
GETENEGITTKTS-KPDEAETNMLTAEMDNFV----CDTVEMSTEEGII----DANKTET
NTEYSKS-E--EKLDNNQMVMESD--ILQEDHHT--SQKVEEPSQCLASGTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPPLVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV-----------------------S
DIIDPVALE--IPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAPGRSPLQPLLETWEDPSVPPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 508)

EQTDAYLT
-----------LTSRMTGEEGKEVIAEIEKNLSRLYTVLKVHISSQNSELSSAALQALGF
CLYNPRITSGLSEANTQELLLTLNGII-KSSDKNVCTRALWVISKQTFPTELVSKMV---
--------------------------SSIIDSLEAILSKGEIHSAVVDFEALNVII----
------RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----GP---------------------------
------------------SEEQVCVPLIQSTISVDSIA-SPQGNSSRGSASPGLSPLTA-
GHKGASPYGTP---RGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLS
LEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDA--SDAVVSAIWKELISLVKSVTE
AGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTQVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLEC-VEDEKFFLNLETLVGCVLSGPTSPLAF
SDSVLTVINENAKQLVNKEHLWRMWSMIVTPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQTFPTGTMKTVLKTWSELYRAFTRCAALVATAEENLCCEELSSKIMCSLED
EALSDLIFLDRISHIIIVMVDCIDFSPYNMKYQPKTKSSQRS-SDWSRKK-KEPLGKLAS
LFKLIVRVIDSFHTLSLKETFSD----TLLAIGNSIISMLSNVFGHISLPSMIREIFATF
TRPLALLYEN-SK--LDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPL
LCIIFLHKNKQIRKQSALLWNATFAKTTALVYPEELKPILRQAKQKILLLLPGLENVEMM
D-ESSEPYSESTENSQLNVKISGM--ERKSSGKRDSILAHTKDKKE-NVK-------LSA
KLKLESSSPKIKSG-KLLEEEKSTDFVFIPPEGKETKTRVLTEHQKEVLKTKRCDIPALY
N-NLDASQDTLFSAQC--SQEESMES--LTLTEKPKEDAKII--------KEEQRESAIF
--IPQDAPGNCGIDEQPEKASLP---------------NCGG-SVAETNPEPLITG-FDA
RKEVLISSK-IMSTEYSSSTETSV-VS--SSSVSDA--------TFSGTP-PQPTSRRQT
FITLEKFDGSE--TRPFSPSPLNNMSSTVT----VRNNQGNTTNTDTPPKARKREVMNS-
-------------QSDSERLANAGKKSS-----RRWSKAE-------QSVAKKSKPSLT-
------------SEQEEHS----------SEN-NSPDLLSPTERVSEN-HDHPF-EATLE
HEDGDPKP-AVENA-SLEDLT-EERNVGINMESKESTASVVAST-EQIVNEDSQAAALAT
NPKTLRRSSRRRSEAADPCSDSQEKESSQQKKERRKEEEKT-ISKSPLHIKDDKLPKQKL
TAEPP--IQENLTEKGNTLHERTPGEPS----------VSAEIDQNKRKPDLENVSSEG-
GGTLDNIDKSSEKPLRGRTRYQTRRASQGLITGVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-IEDQEEKMAEEEVMKTANQTHDG---------QALPD
VDINT--AAQVSEKST--NKVILQDS--SGSVDSLQVPP-----TG----EDKSKTSKCV
DSS-----FVSLPVPESNLRTRNASKR-LY----KRDTD--S-------NVKVSDSSLSP
EKFTQVVECQHKRS-RRVRRSKSCDCCGEKSQFQE--KSFIGLKNSESYAIKSVEKKKTD
IQVPVTAPETPEA-SDHAETKLAG-EQPIVNSHLGLKEENCTTGD-SVKYEPELEEA---
--SLS-SEIVTMKEK--THDIDARSEAVSEV-------QEPCSEKHSAAEDPCLSECKDI
SQN-PLSEN-------------------R--EFDISDV-----GKVCKV----------I
AGSSPEGV-ETVDL---K----DAFVAAVS-EKSPQMDVST-----------IDVA----
TEGDNKE-DECEAV-TAEVN-AEGVATEDFNSSMGLSDTPTPVSK-D-------------
--------VEI--EHPASGEIEGDS-NESDSGSCEEMN-KEMESQKAQ----MNTEIDNA
R-VKEMDMIAS-TSKSEEALIGRLDINTESLV----SDIEMG-AG-----ERTVNCKTET
SIELNKLDE--AKLSDNETAVGND--TLQEICFT--SEKTEELPQSLIPQVAS-ELAAES
NTA-SPEK-LELD--P-FGSVSESPSG--MQ-ARCVWSPLASPSTSILKRGLKRT-QEDE
I-SPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRPH-SSNSSPIIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSSKFKSSKKCLITEMAQEPMLSPT-ESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPIFDISEKAVNGVESKTVSTDEERFA-----------------------S
DLIDPVTLDP--PLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSASHGGQTDAYLT
-----------LTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLSDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGVSSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIIKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLFMDRIIHTITVMVDCIDFSPYNIKYQLKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTMLVYPEELKPVLTQAKQKFLLLLPGLETVEVM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NMK-------PAA
KLKLESSSLKVKSE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEEPMEI--PTLTRKPKEDSKMMI-------TEEHMDSDIV
--IPQDVTEDCGMDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SEPEKNTEESIEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESTVE
HDNTKLKAATMENAVLLETNAVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
TQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--PQENLIEKGSNLHEKTLGETS----------VNAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNEIVD-IQDQEEKVVKQECIKAENPSHDY---------KAGSE
EDVSI--KPQICEKQDESSTVICQDS--TVTSDVLQVPDDLP-NAC----EEKSETSKYA
EYS-----FTSLPVPESNLRTRNAVKRLHK----RDSVDNCSL--GESSKTGISDISSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQLQE--KSLVGLKNTENNDVEISETKKAD
VQAPVSLSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFREE--ICDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------EKPEETP---K-MELSLEN-V-TFEGNACKV-----------
TESNLEKA-KTMELDVGN-------EASFH-GQERTKTGIS-----------EEAA----
IEKNK-RNDDSEADTA-KLN-AKEVATEEFNSDISLSDTATPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDPHSSEETN-TEMKNYEEMMIGEAKAETGHD
GETENEGITTKTS-KPDEAETKMLTAEMDNFV----CDTVEMSTEEGII----DANKSET
NTECSKS-E--EKLD-NQMVMESD--ILQEDHHT--SQKVEEPSQCLTSGTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV-----------------------S
DIIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSIMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAPGASPLAPLLETLEDPSAPLG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 504)

EQTDAYLT
-----------LTSRMTGEDGKEVIMEIERKLSRLFRVLKIHISSQNSDLSSAALQALGF
CLYNPKITSGLSDTDIEELLLKLNDSV-KSSDKNVRTRALWVISKQTFSTEIIGKVV---
--------------------------STIIDSLEIVFNRGELHSAVVDYEALNVII----
------RLIEQAPVQMGEESIRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-LPQGSSSRVATSPGLNPMTPI
HK-GASPYGTPVTPRMNLSSNFGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQNKLVLS
LEPLEHPLISSSSFFSKHASTLITAVHDSFVAVGKDA--SEAVVNAIWKELISLMKSIIE
SGNKKERPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLEYGVEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKLLENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSVQKFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIVLSHT-
-------DLDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-KEPLGKLAS
LFKLIVKVIYSFHTLSFKEVHSD----TLLTVGNSVTSILSKVLGRISLPSMIRKIFATL
SRPLALFYEN-SK--LDEVPKVYSCMSNKLEKLLGEIITCLHFSYTGTYDSELLEHISPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTMLTYPEELKPILRQAKQKFLLLLPGLENVEFM
E-ESSGPYSDGTENSQLNMKISGM--ERKSSGKRDSFLAQTKDAKE-NMK-------PPG
QLKLESPSPKTKSE-MPLEEEKSVDFVFIPSEGKEAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFS-QY--THEESFFI--LRYPHKVRLICRLIYICVYFSVQEEQMESDIA
--IPQDVTENCGMDEHPEKGSLS---------------NNESGSIEETSPDILSS-NNDA
RKKALNSST-KTPTECASSAENTFGVN--SSSVSNV--------IISGTP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VKNNQENMSKTDIPSKTKKREIALV-
-------------KSDSEKIVHGIKRSS-----RKSSKGE-------QTGNKRSKLLMR-
------------SEQEKNTQESVDGMV-ALEN-NQPGLLNQTECMLDNNHTHLS-ESAVE
YEDMVLKP-TIENAVLLENSTVEDTTLGINLESKENTPPTVTPA-DQIVDEDSTIQ-ITP
SQKTLRRSSRRRSEIAEPTTDSQEKENN-QKKERRKEEEKP-LQKSPLHVKDDLLLKQKL
ISEQT--VQEN-VEKGTNLHEKTFGETS----------TNAEIDESKRKLDLENIKSEGD
G-AQDIAEKSSEKPVSGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKSSDSVD-IEDQEEKVVKQECINIENQTLDC---------KANSD
VDRDI--KSQICEQKDESS-VTLEDS--TVSSDLLQVSD-----------DGKIKTNKCA
EYS-----FSNPSVPESNLRTRNASKRLQK----RDSVENNR----------TSDISLLS
EKSSQTLECQHKRS-RRVRRSKSCECCGEKSQPQE--KSLIGLKNMENYDVKVTETKKTD
MQTAVPVSET-SKVNLYSEVKLAD-EHHAVNFHLGLKEENDTVNDSLVISETEFKEDTV-
-QNPLPSEVVNFEQE--TCDTNSAEATSLES-------QGPSNKKCK-TV----------
-----------------------------------ENIA-SVETNACEA----------E
AIFNPEVV-EAVELDTES----DQSEAGLS-EQKDAKT-----------VV-FEEV----
MEINSERSEA-----AEEPN-AEETVTKEFNSGIGYSDDTTSVKVS--------------
--------AQAEIPEQTAVGELDEGSDESSPNSSEEMN-AKMENFEETVISEVNAEADQV
SETEDGDLTTKISTKLVQANTKTLTMGIDSFV----FNTLEMSIEEGEV----DSNKTEA
NIELSKSEE--TTLDDNQMVEGND-EILQEVHPT--SEKVEETSQSLTSETAISELITE-
DNNASPQKLRELD--PLLLSANGSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-HEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNNSPTVKS---VKTSL-TQ
SKHNATSTKGFLSSGSRSPKFKSSKKCLITEMAKEPVPCPA-ESVYPALVNCVAPVDIIL
PQITSNIWARGLGQLIR----------------------------------AL-RVYHEQ
QVKSRGLEEIPVFDISEKTINGIQTKSLPSDEERLA-----------------------S
DLIDPVALE--TSLPKNLMAQISALAVQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSI--------------

MGGAIDDVGAPPPCWTRSGLRGQACPTPARPRARPRRHLGPAGSGPHARVN-RPRR----
GVAFGGVGRR----GRTRPCCACVGAADMTAPAGSPLAPLLETLDD

PF12231 // ENSGT00390000012204_0_Domain_1 (107, 513)

ASAAPGEQADAYLA
-----------LSSRMTGEDGKEVVTEIEKRLPQLLRVLKIHISSQNSDLSSAALQALGF
CLYNPKITVGLSETDIQELLLKLNDSV-KSPDKNVRTRALWVISKQTFPAEVIGKVV---
--------------------------STIIDSLEIVFNRGEMHSAVVDYEALNVII----
------RLIEQAPVQMGEESIRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELHKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SAQGSSSRVAASPGLSPMTPI
HK-GASPFGTTVTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQNKLVLS
LEPLEHPLISSSSFFSKHANTLITAVHDSFVAVGKDA--SDVVVNAIWKELISLMKSVIE
SGNKKERPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVSNM
DILN--------GTPALFLIRLIF-NNNLLEYGVEDERFFLNLETLVVCVLSGPTSPLAF
SDSVLNVINQNAKLLENKEHLWRMWSIIVTPLIELINQTNEVNQGDALEHNFSAIYGALT
LPIHHIFSVQKFPVATMKTLLKTWSELYRAFARCAALVATAEENLCCEELCSKMMSSLED
SGFSNVLFLDRIIHIITVMVDCIDFSPYNIKYQPKIKPPQRP-SDWSKKK-KEPLGKLAS
LFKLIVRVIYSFHTLSLKEVHSD----TLLTVGNSITSILSNVLGRISLPSMIRKIFATL
TRPLALFYEN-LK--LDEVPKVYSCMSNKLEKLLGEIIACLHFNYTGTYDSELLEQISPL
LCIIFLHKNKHIRKQSAQFWNATFAKATMLTYPEELKPVLRQAKQKFLLLLPGLENVEIM
E-ESSGPYSDATEYSQLNMKISGM--ERKSSGRRDSFLAQTKDAKE-NMK-------PPV
KLKLESSSSKTKSE-MPLEEEKSTDFVFIPPEGKESKERILTEHQKEVLKTKRYDIPAMY
N-NLDVSQDT-FS-QY--TQEESVEI--PTLTEKSKEDSKVIF-------KDGQTESDIV
--FPQDVTENCGTDEHLGKASLS---------------NE-CVSN-DTNPKILSS-NNDA
RKKALISSK--KTTKCASSAENTSGVN--SSSFSNA--------VISGTP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLSNMSSTVT----VKNNQEVMNKTDIPPKAKKREMAFV-
-------------KSDSEKIVHGIKKSS-----RRSNKAE-------QTGNKRSKLLMR-
------------SDQEKNTQESIDGTV-VLEN-NPPGLLNQTECVLDN-LAHLS-ESAVE
NEDTMLKP-TIENAVLLENNTVEEK-TGISLESKENTPPAVIPA-DQIVDEDSPVQ-ITP
NQKTLRRSSRRRSEI-EPTTDSQEKENNPQKKERRKEEEKT-LQKSPLHVKDDAIPKPKV
IFEQS--VQDNIIEKGNNLHEKTFGETS----------TIDEIDESKRKLDLENIKSEGD
G-AQDIADKPSEKPVSGRTRYQTRRASQGLLSSIENSESDSSEAKEEGPKKKRSGKWK--
--------------NKSNDSVD-IEDPEEKVIKQECINIQHQTLDP---------KANSE
VERDL--KSQICEQKEENN-VTIEDS--TASSDLSQVSDDVP-NTY----EGKSKTNKCA
EYS-----FSNPSVPESNLRTRNASKRLQK----RDSVENNTV--GESSKTGTSDVSLLS
EKTLQMLECQHKRS-KRVRRSKGCDCCGEKSQPQE--KSFIGLKSTENYDVKVSETKKTD
TQTPVTVSET---SNLCSEVKLLDDEHHSVNFHLDLKEENDAINDSLVISETELKENPT-
-QNPLPSEVVSV-EE--TCDMDSEEATSLES-------QEPANKKCK-TASPCLSDSKDN
SLEHCSALETNE------EKPESVL---E-KEVSLENIV-SAETNACKI----------K
AEFDPEEA-EAIELDIES----DKSEASFS-EQKSTET-----------DVLEEEV----
MEIKSERSDESEAETAEELE-A-----EEFKSDIGHSDNTTPIEVN--------------
--------AQVEIPKQTAAGELDEGSDESGPGSSEEVN-AETENCEETVIGEVSSETDQV
RETEDGDS-TKISTIPVEAETKTSATEISNFV----PNTLEISTEEGKVV---DSNKTET
NTEFSKSEE--TILENNRMVEGND-EVLQEVHHT--SEKVEETSQSRTSETAISDLVTE-
DNNASPQKLRELD--PLFISANGSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCCNVRSH-SSNSSPIVKS---VKTSPTAH
FKHNATSTKGFLSPGSRSPKFKSSKKCLITEMVKESMPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVRKAL-RVYHEQ
QVKSRGLEEIPVFDITEKTVNGIQTKSVPSDEERLA-----------------------S
DLIDPVALE--TPLPKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPTHENSI--------------

------------------------------------------------------------
----------------------------MTAPGPSHLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SQGEQTDAYLT
-----------LTSRMTGEEGKEIIIEIEKKLPRLFKVLKNHITSQNSELSSAALQALGF
CLYNPKITSALSETIIQELLSKLNDTI-KSSDKNVRTRALWVISKQTFPPEVLGKVV---
--------------------------SSIIDSLEIVYNRGEMHSAVVDYEALNVII----
------RLIEQAPIQMGEESIRWAKVVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGSSSRVATSPGLNPMTPV
HKG-----ASPVTPRMNLSSNFGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLILS
LEPLEHPLISSSSFFSKHANTLITAVHDSFVAVGKDA--SDAVIGAIWKELISLVKSVVE
SGNRKERPGSEVLTLLLKCLESIVKSEVFPVSKMLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNN-LECGVEDERFFLSLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQKIPVATMKTLLKTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGLSNLLFLDRIIHIVTVMVDCIDFSPYNIKYQPKIKSPQRP-SDWSKKK-KEPLGKLAS
LFKLIVRVIYSFHTLSLKEVHCD----TLLIIGNSIISILSNVLGHISLPSMIRKIFATL
TKPLVLFYEN-SK--FDEVPKVYTCMNTKLEKLLGEIIACLHISYTGTYDSELLEQISPL
LCVIFSHKNKQIRKQSAQFWNATFAKVAMLIYPEELKPVLRQAKQKSLLLLPGLENVEIM
E-ESSGPYSDTTENSQLNMKISGM--ERKSSGKRDSFLAQTKDAKE-SMK-------PVA
KSKLESSTPKSKSE-MLLEEEMSTDFVFIPPEGKETKERILTEHQKEVLKAKRCDIPAMY
N-NLDVSQDTLFS-QY--SQEESMEI--PTLTEKSKEDSKMIF-------KEEQKESDTV
--IPQLVVENRGMDEHLEKATFS---------------NNENGSVEETSSEILSS-NEDA
RGKTLVIRK-KTTTECASSTENTVVVS--SNSVSNV--------TIPGNP-PQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VKNSQEGTTKTDNPSKAKK--VVLL-
-------------QSDSEKIVHGIKRSG-----RKSSRSE-------PTGNKKSKPLMR-
------------SDQEKSTRESFDGMV-ALEN-NPPGLLNETECVLDH-QVHLS-ESAVE
YGDTTLKP-TVENAVLLESSTVEDKSLEINLESKENTPPAITTA-DQTVNEDSHVQ-VTS
NQKTLRRSLRRRSETTEPATDSQDKENNHQKRERRKEEEKT-LQKSPLHVKDDVLPKQKL
MSEQT--VQENLIEKGSNLHEKTLGETS----------ADVEIDENRRKPDLEDTKSEGG
G-TQDVTDKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKSSDSVD-IEDQEEKMVRQESIKVENQTHDY---------EMNSE
VDKDI--KSQICEKD-DIDIITLQDS--TVSSDLFQVSDDVS-N------EGKSKTYRCA
EHS-----FSNPPVPESNLRTRNANKRLQK----RDSIEN-SV--GESSKTGTSDISLLS
EKTLQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSFIGLKNTENFDVKVSET-KAD
VQTPVTISEP-SKADLHSEVKLSD-EHHSVNFHLDLKEENDTINDSSVISESEFKENI--
-QDSFPSEMVNLNEE--TCDRTTEEAVSLES-------QEPSNKRCK-TLGPCLDDSKDT
SLE-CFTLETKE------EKPAEAT---PEKELSVENIV-NAEENECKV-----------
KELNQEVD-DAMELEVES----DKSEVSFF-EQKSDIS--------------KEGL----
MEEISEGKDTSEAHVAEEMN-ADEAVTEEFNSDVGHSDSTTSVKVR--------------
--------TQMEFSEQIAVGKLDRGSDESDPGSSEEMN-AETENCAETVIGEVTAETDHI
SETEDEDFTSK-ASKPVEAETKGLNVEMDSFV----PDTLEMSTEEGKV----DPRKTET
NVELNKFDK--TELDDNHMVVRND-GILQEVHHT--SEKVEETPQSLTSETAVSELIPE-
DNNTSPQKLKDLD--PLLMSTNDSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIIRCH-SSNSSSMVKS---AKTSPTAH
SKHNTTSTKGFLSPGSRSPKFKSSKKCLIAEMAKESVPCPT-ESVYPALVNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RVYHEQ
QVKSRGLEEIPVFDISEKTINGMENKSVSPDEERLA-----------------------S
DLIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANCIIKNL
QSRWRSPAHENSI--------------

------------------------------------------------------------
----------------------------MSAPGENPLLPLLETLEDSCASPGE

PF12231 // ENSGT00390000012204_0_Domain_1 (114, 504)

LTDAYLA
-----------LTSRMTGE-GKEVILEIEKNLPRLHRVLKIHISSQNSELSSAALQALGF
CLYNPKITSGLSETNIQELLSELNNIV-KSSDKNVRTRALWVISKQTFPTEVVGKMV---
--------------------------SSIIDSLETVFNKGEIHSAVVDFEALNVII----
------RLIEQAPIQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEV
ASITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSIIS-DASS-SPQGNSSRVATSPGLNPMTPV
HK-GASSYGVTGTPRINMSTNLGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQHKLVLS
LEPLEHPLISSPSFFSKHAHTLITAVHDSFIAVGRDA--SDAVVSAIWKELISLVNSLTE
SGNKKERPGSEVLTLLLKYLENIVKSEVLPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIHLTF-SSYLQECGIADERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINHNAKQLENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYSALT
LPINHIFSVQRFPVVTMKALLRTWSELYRVFARCAALVATAEENLCCEELSSKIMSSLEE
ETFLNLLFLDRIIHIITVIVDCIDFSPYNTKYQPRIKSPQRS-SDWAKKK-KDPLGKLAS
LFKLIVRVICSFHTLSFKEAHSD----ALLSVGNSIISMISNLLGHISLPSVIRQIFAVL
TRPLALFYEN-SK--LDEVPKVYSSLNNKLEKLLGEIITCLQSS-GGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKMMILNYPEELKPVLREAKQKFVLLLPGLENVELI
E-ESSGSYSDATENSQLNMKISGM--ERKSNGKRDSFLAQTKGKKE-NMK-------PSA
KLKRESSSPKVKSE-ILLEEEKSTDFVFIPPEGKELKERILTEHQKEVFKTKRCDIPAMY
N-NLDVSQDALFSDHY--SQEEAMQT--PTLTEKPKEDTKMVI-------KEEQMKSDTI
--I-QDALENCGMDEHIKKASFP---------------NNEYGFVPKTDPEILSS-NSKA
RKNSLISSK-KTSTEGTSSAENAV-VS--SCSVSDA--------SISGTP-PQPTSRRQS
FITLEKFDGSD--NRPFSPSSLSNI-SDVS----VQNNCENMTTADSTPKTKKREVMHS-
-------------KSDSEKILNGVKRSS-----RRLSKAE-------RSTSKRSKPLIK-
------------SEQEENNQEPVEGTI-ALEN-NSPDLLNQTACSSDG-QVHCS-EPIAK
HEDRKPKP-ALENAVLLENDPVQEKNMGINLESKENTPPAVTPA-DQMVNEDNHVQ-VTP
NQKTLRRSLRRRSEITDCIGDNQDKENSHQKRERRKEEEKT-QSL--L----HVLPKQKL
ISQQT--EQENVLEKENNLHEKASGETS----------ANADIDLNKRKPDLENVNSEGD
S-ALDLVDKSSEKPLRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKSK--
--------------NKNSESVD-IEEQE-KVIEKASLSVENHTQDH---------KATSE
VDVDK--KPQVCEKD-E-SPVILQDS--TAATDSLQVSD-VP-HTY----EGKTKTSKCA
EYT-----CASSPIPESNLRTRNASKRLLK----RDSD-N-SV--GECSKTGTSEI---S
EKNVQTFECQHKRS-RRVRRSKGCDCCGEKSQLQE--KSLTGLKNTENSDIKSSQTKKTD
VQTPDKILETDSKANLCSEAKVLD-ECASVCFNLVLKG-NDTIND--FVPETELKENTI-
-KKS--SEIVNLKDK--PCDVDFGEVVSLEI-------EEPTNKKFK-AAGPCLADCKDF
SEE--YHLDPKE------ENTETTL---KK-ELD---VN-I-EGNACKA----------I
GESNLEEI-KAMEFDVEN-----KSEATVS-EKESVKTDIS-----------KV------
AAEECKSSDEPNTETADR-D-VEA-AAEEFYSGVGLCDNTTSIIVN--------------
--------TQTEISKQI-GGELGGRSNESDSGTSEEVN-AKMENNEEMVIGHMNNEIASV
RESEDEAMTTK--TKSEDTKTGQLRAEMDSFV----LNKLEMTTEEGKI----ETHKTET
NTELSKSKE--TNLDDNQ-IMGND--ILLDVNHT--PDKVEEPSQSLTSEATISEMVTE-
D-NSSPEKLRELD--SLFMSASDSPSG--M-QTRCVWSPLASPSTSILKRGLKRL-QEDE
SSSPVNK--VRRVSFADPIYQAGLADDIDRRCSLVRSH-SSNSSPVMKN---VKTSPTTQ
TKHITTSAKGFLSPGSRNCKFKSSKKCLITEMTKESMPCPT-ESVYPALMNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLCTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QMKSHGLEEIPVFDISEKTLNGIENKS--ADEERLP-----------------------S
DLINPVALE--TPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLGTMANSIIKNL
QSRWRSPAPENSKDTSHLKECLIHISS

------------------------------------------------------------
----------------------------MTAAGRSPLEPLLETWEDPSVSPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 502)

EQTDAYLT
-----------LTSRMTGEEGKEVITEIEKNLPRLYTVLKAHISSQNSELSSAALQALGF
CLYNPKIASGLSEANIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPSELVSKMV---
--------------------------SSIIDSLEVLLSKGEVHSAVVDFEALNVII----
------RLIEQAPVKMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGIPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPGNFEQKPCLEK------------P----------------KP-
--------------KQNKK-----------------------------------------
------------RFLE---TV-----------FLISL--IDAVVSAIWKELISLVKSVTE
SGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVSNM
DILN--------GTPALFLIQLIF-NNNLVECGVADEKFFLNLETLVECVLSGPTSPLAF
SDSVLSVINQNAKQLGNKEHLWRMWSIIVTPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQSFPMATMKTLLKTWSELYRAFTRCAALVATAEENLCCEELSSKIMCNLED
EVLSDLLFLDRISQIIIVMVDCIDFSPYNIKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVRVINSFHTLSFKEKCSD----ALFPIGNSIISMLSNIFGHISLPSMIREIFATF
TRPMALLYEN-SK--LDEVPKVYSSLNNKLEKLLGEVVACLQYNYSGAYDSELLGQLSPL
LCIVFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILREAKQKTLLLLPGLENVEMM
D-ESSVPYSDATENSQLNVKISGM--ERKSSGKRDSFLAQTKDKKE-NTK-------LSA
KLKLESSSPKLKN-SKLLEEEKSTDFVFIPPEGKEAKARVLTEHQKEVLKTKRCDIPALY
N-NLDVSQDTLFSAQF--SQEESMES--PTLTEKPKEDTKII--------KEEQTESAAF
--IPQDAVENCGMNEHPEKTSLP---------------NDCG-SVAETNSEMLSSG-IDA
TKNTLIASK-IMSAECSSTTESSLV-N--SSSVSNT--------TVSGTP--QPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VRNNQENTTKTDTPPKARKREMTHS-
-------------KSDSEKLVNGGKKSG-----RRWSKAE-------PSANKKCKPSLR-
------------SEQEEHV----------SEN-TSPDLLSQTECESKN-HDHPS-EAVLD
HEGRTPKP-TVKNA-LLEDSTTEEKNIGIIMESKENTPSVPTPA-DQTVSEDSQAA-VAA
NPKTLRRSSRRRSEMVESSTDSQDKDNGQPKKERRKEEEKA-VPKSPLHTKDDKLPKQKL
TAELP--IQDNLTEKESSLHEKTIEEPN----------VNAEIDQNKRKSDLEDVSSEG-
GSTQDNVEKSSEKPLRGRTRYQTRRASQGLLSSVENSESDSSEAKEEVTRKKRSGKWK--
--------------SKNSDSVD-VGEQEEKMVQEECIKTANETHDG---------QTVPE
VDVDA--VAQICEEST--DRVILQES--TGSSDSLQVTD-TP-VTG----EDSSKTSKCV
DNS-----FASSPMPESNLRTRNASKRFHK-----RDID-------------IVDISMPS
EKWTQAVECQHKRS-RRVRRSKSCDCCGEKSLSQE--KSFIGLQDTESCAIKSMETN-TE
MQTPETIPETCDA-NEHTETKLVD-EQPITNFYLGPKEENSTAGD-LTRSETASEEDRK-
-NILP-SE---------IVNTDS-SEIVSEI-------QEPRNESFN-AEDPCLSDSKDT
SRK-YSSDN---------------------QEFDTSSV-----GNVCKV----------I
AGSNSEDV-EAMEFDVGD----VKFGASSS-EQKSGQLDVS-----------VDMA----
MEEDNKK-DEFEAV-TTEVN-GEGTATEGSNFGIDLSGKTTPVQ----------------
----------T--EHLARVKLE-------RIGSCEEMS-KEMESCKAVIA--QLTETDNT
G-EKDRSMIVS-SST-SEEPVGRLDVQTENFV----CDIPEKSCE-----EESFYHKIER
NIELNKLDE--TKLSGNPTGVGND--NLQEVCPT--SEKVEELPQSLTSEVAS-ELVAES
NNNVSPEKLRELD--PSFGSANESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-HEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSV-RSH-SSISSPIIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSPKFRSSKKCLITEMAKESMLSPTTESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPVFDISEKAVNGVESKPLSTDEERLA-----------------------S
DLIDPVTLDT--PLSKNLMAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTDRGQSPLAPLLETLEDSS

PF12231 // ENSGT00390000012204_0_Domain_1 (109, 504)

ASHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANVQELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKVV---
--------------------------SRIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGSPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLLRLGPHLPANFEQVCVPLIQSTISIDCNA-SPQGNSCRVATSPGLTPMTPV
NKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLAPEVLNFAKQNKFVLS
LEPLEHPLISSPSFFSKHANTLITAVRDSFVAVGKEA--PDVVVSAIWKELINLVKSVTE
SGNKKERPGSEVLTLSLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVADERFFLSLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYTTFARCAALVATAEENLCCEELSSKMMSSLKD
EDFSNLLFVDRIIHVITVMVDCIDFSPYNNKYQPKVKSPQKP-SDWSKKK-NEPLGKLTS
LFKLIVKVICSFHTLSFKEAHSD----TLFTIGNSITSIISSVLGHISLPSMIRKIFASF
TRPLAVFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEHLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTMLVYPEELKPVLRQAKQKFLLLLPGLETVEMM
EEESSGPYSDGAENSQFNVKISGM--ERKSNGRRDSFLAQAKNKKE-NMK-------PAA
KLKLESSSL--KSE-ILLEEEKSTDFVFIPPEEKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTSTRKPKEDSKMTI-------TEEQMDGDIV
--IPQDVTEDRGTDEHLEKTPLS---------------NDECGSLDKTSPEMM-NSNNDA
RKKALISSK-KTSIECASSVENSSVIS--SSLFSNA--------AVSGTP-PHPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VKSNQETIIKTDSPPKAKQREGTIS-
-------------KSDSEKIVTGTKRSS-----RRAGKAE-------QTESKRFKPIMR-
------------SEQEKNIEESIEGMV-VLEN-NSPGLLNQTECVSDN-QVHLS-ESTME
HDSTKLKA-TMESVVLLETNTVEEKSVEINLESKENTPPVVIPA-DQMVNEDSQSQ-ITA
NQKTLRRSSRRRSEIVESTTDSQDKENNHQKKERRKEEEKP-LQKSPLHMKDDMLPKQKL
ISEQT--VQENLIEKGNNLHEKTAGETS----------ANAEIEQNKKKPDPENIKFEGV
S-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKNNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSE
ENINI--KPQICEKQDDGST-TYQDS--TVTSGLLQVPDDLP-NVC----EETNKTSKCA
EYP-----FTSLTVPESNLRTRNAIKRLYR----RDSFDNCSV--GESSKMGTSDISSLS
EKTLQTLECQHKRS-RRVRRSKSCDCCGEKPQPQE--K----LKNTENNDVEINETKKAD
VQTPIVTSET-SQPNPDSEGQFLD-EHHSVYFNLGLKEDNDTVNDSLIVSETKLKENTM-
-QESP-SEIINFREE--TCDKDSSEAVSVES-------QESSNENFK-TVGSCLGDLENA
SQE---SLETKE-------KLEEIP---K-KELSLEY-V-TVEGSACKV-----------
TESNLEKV-ETMELDVGN-------EASFP-EQENTKTDIS-----------EEAA----
IEEN-NTNDESEADTA-KLN-AEEAASDEFNSGISLSDNTTPIKLN--------------
--------AWTEISEQTAVGELGGGSDVCDPCSSEKTN-TEIENYQETMIGEAKAETGHD
DETENEIITTKTS-KSDEAETKMLNAEMDNFV----CDTVEMSAEEGII----DSNKNEI
NTECSKS-E--EKLDNNQMIRESD--ILQGDH-T--SEKVEEPSRSLTSGTAISELIIEE
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPVAQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCMAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGMENKSLSPDEERLA-----------------------S
GTVDTVALE--TPLSRNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPPHENSV--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KNSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETRSAVVDFEALNVIV----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHALSFKEAHSD----TLFTIGNSITSIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSSLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NMK-------PAA
KLKLESSSLKVKGE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEEPMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDCGMAEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDE
RKKALISSR-KTSTECASSTENSFVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKVVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SEPEKNTEESVEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESTME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
IAELT--LQENLIEKGSNLHEKTLGETS----------ANAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSE
EDVSI--KSPICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NVC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDISLLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLIGLKNTENNDVEISETKKAD
VQAPVSPSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIVSETKSKENTM-
-QESLPSGIVNFREE--ICDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------GKPEETP---K-MELSLEN-V-AVEGNACKV-----------
TESNLEKA-KTMELDVGN-------EASFH-GQERTKTGIS-----------EEAA----
IEENYKINDDSEADTA-KLN-AKEVATEEFNSDISLSDNATPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDLHSSEETN-TKMKNYEEMMIGEAMAETGHD
GETENEGITTKTS-KPDEAETNMLTAEMDNFV----CDTVEMSTEEGII----DANKTET
NTEYSKS-E--EKLDNNQMVMESD--ILQEDYHT--SQKVEEPSQCLASGTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPPLVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV-----------------------S
DIIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SIVFGYAI------------LTISYFICIY----
------LVCFLAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--ADVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEPRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLLDRIIHIITIMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGDSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFNYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSADFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKM-I-------TEEQLDSDIV
--IPQGVTEDRGMDEHLEKASLS---------------NNECGSLGKTSPEMS-NSNNDD
RKKALISSK-KTLTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSLLNNISSTVT----VKNNQETMIKTDFLPKAKQREGSFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNTKSKPLIR-
------------SEQEKNTEESIEGMV-VLEN-NPSDLLNQTECVSDN-QVHLS-ESIME
HDNTKLKAATMENAVLLETNTVEEKTVEINLESKENTPPVVIST-DHLVNEDSLVL-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVSPKQKL
ISEQT--VPENLIEKGNNLHEKTLGENS----------ANAETEQKKKKPDPDNIKSEGD
G-TQDVIDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSEILQVPDDLP-NPC----EEKNETSKYA
DYS-----FTSLLVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGTSDVSLLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEISETKKAD
VQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDVDSSEAMSLES-------QESPNENFK-TVGPCSGDSRNV
SQE---SLETKE------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TEPNLEKV-ETMELDVGN-------EASFH-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATEEFNSDVSLSDNTTPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDPHSSEETN-IEMKNDKEMKIGEVKAETGHD
GETENEGINTKTL-KPDEAETKMLTAEAENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNQMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PLLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVALES-SPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANSIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------

PF12231 // ENSGT00390000012204_0_Domain_1 (316, 440)

MGEEAVRWAKLIIPLVVHSAHKVQLRGATALEMGMPLLLQKQQEV
AAVTEHLMTTKLISELQKLFSAKNETFVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSSSPVVKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPHLPSNFEQVCVPLIQSTLSVDPAAAAFPGTPSR-PNNPSLGSATPG
QKSGPFPFVSPGTPRMALNSSTAAVVQFPSIQLLGIEMLLHFLMGPQVVDFAKQNKLVLS
LEPLQYPLISSPSFFCKHASTLINAVQDGFVAIGKEV--PDCLLNVIWKDINGFVKTAIE
AGNKKEKQGSEILTMLLQALKNTVRSNSLPVQKMLSLIDITVKELPPKVLGSPAYQVADM
DLLN--------GTPALFLIQLPF-HNNLLECCVTDERFFGILETLVGFALSGPTSALAF
SESVLCVIDQSAQQVGNKEHLWRMWSIVVNPLTEWINQNNEVNQGDALEHNFSAVYSALL
LPVSHIFPTQGFPQPTLKSLLRSWSDLYRAFARCAALVATAEENLCCEELCAKIISGLEG
ETPVVFSMLEGLTHLVSVMVDCINFAPYGTKFQPKTRSPQTP-TDWAKKK-KEPLGKLSS
LFKLLLLLLNSFHELSCREVHSE----PLTAVGPSLLAALHSIISHISLPSLLGTTLAFF
SKPLAVFYEK-NK--LPEVPKVYSNLNTKLEKLLAEMLQCLQCHCPGSCDSELLQQLSPV
LCLAFQHRSKQLRQQSAQLWNCTFAKASSLTYPEELKSVLSQAKKKIPLLLPGFESIEMS
E-ECSGPFSDMMENSQLDAKISGM--EVKVGQKRDSILAQTSEPKNDGKDKSSNVQATPA
KLKLEFSSPKTT-SETLLEEEKSVDFVFIPPE---TKPRILTEHQKEVLRSKRADIPAMY
N-TLDASQDTSSFSQYTQSQEDSLEV--PPLVENAKEEPANQP-------QEEEAGSEGC
HSEESPAC------------------------------SGEGEA-KNETAEMIPEE-SSI
GEGLETSSVEAASQEASAEKEDTSNVT--SSSASSD--------IISGTP--QPVSRRQS
FITLEKFGAAE--SRAFSPAPLSSVLELPGSAPEAA-TQENSSGSKASAKAERSGEENKN
VPKC-------------E--AGATRR-VT----RQQSRME-------LQGHKAKL-----
---------------QGRPEESLASD-------SLEGSAELGSAVEGVEHVLLSQAQTLP
PSEPDIQK-MEDAAPKME------KVQELDMDSKENTPPESSSCSEQAPGDDSQVPAASP
QQKQLRRSSRRRPETLE-SSGSQEKEDGLPKRDRRKEEEKA-GQKKLSQGKGDGSQKQKG
IAGKTTQSTK-----ESSQAE-RVAEDWSCKDSAACRGLEEEGSRGGRRAEDSP-RPEG-
EAQ--GSLSTAGQK-VERPRYHTRRSSQGLLSSIENSEADSSDSKEESTKKRKTIKVR--
--------------SRSSS-LE-GKLKEEQAGSQSLEGSPQ-GNGAKSPVEANKG--DPE
VSTGAAV---PAEPGGLESQEIPAAAGEAVGSGSSENS-----GALQDTSVEQNNG-DAS
MES-----LSSPCVSEQDGRAAEESKQEEK----QSS-------PGDCAPA-A-NASAAE
PSSLQSHECQSKRS-KRVKKIKSCDCCFKKPKLQVTETKLTEPKKEKAPEL--EEPESSP
VQTP---GNV-SGHSDLEESLALA-P-CGMSTPKE----PSSFSLESQGVA-----LEN-
---------------------MEGSSVVVE--------EENPEN----------------
-------------------------------------------------P----------
EGSAAETTESTEEIKEPA------EEKEQ--TEQVLPESVPAEPRESCLDSG--------
----D--QGEEPAAAEKEEI-TENRQVEEVPEEL--------------------------
-------------------------------------SVDSKP------------EEKEM
---------------------KEP---EGNQEDKGEA---ESS-------AGETCVV---
----------------------PDQEMKD----ELMEAEIKVPENVAL--ANT-------
-SVDSPLKVEGD-P---QVQVTESPTS--L-QARCTWSPSASPSTSILKRGVKRS-QEDD
SLSPANK--IRRVSFANPIFQEGLADDIDRRSPVIRSH-SSPSSRSLKI---L---SNMQ
--HITTPTKGFLSPGSRTLKFKSSKKCLITEMAKESLPCLT-EFVYPALAGCKAPVDVIL
PQITSNICARGLGQLIRAK-NIKTVGDLSTLTALEIKTLPIRSPKVSNVKRAL-KGYHEQ
QVKSRAVEESSVLEDAEKPGNDVEEKPLCGEEEKLA-----------------------A
DLVE--APTSSEQPPVDLLGQIQALAAQLSSADLHGYSGRQLFEMQEQLAGMASCILRNL
QARWSSPPHQGPE--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDSS

PF12231 // ENSGT00390000012204_0_Domain_1 (109, 504)

ASHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANVQELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKVV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPIQMGEEAVRWAKLVLPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTAKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGSPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLLRLGPHLPANFEQVCVPLIQSTISIDCNA-SPQGNSCRVATSPGLTPMTPV
NKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLAPEVLSFAKQNKFVLS
LEPLEHPLISSPSFFSKHANTLITAVRDSFVAVGKDA--PDVVVSAIWKELINLVKSVTE
SGNKKERPGSEVLTLSLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVADERFFLSLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEYLWRMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRTFARCAALVATAEENLCCEELSSKMMSSLED
EDFSNLLFVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLTVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLGRISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIVCLQFSYTGTYDSELLEHLSPL
LCIIFLHKNKQIRKQSAEFWNATFAKVTMLVYPEELKPVLRQAKQKFLLLLPGLETVEMM
EEESSGPYSDGTENSQLNVKISGM--ERKSNGRRDSFLAQTKNKKE-NMK-------PAA
KLKLQSSSLKVKSE-ILLEEEKSTDFVFIPPEEKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLL-TQY--SQEASMEI--PTSTRKPKEDSKMMI-------MEEQMDSDIV
--ILQDVTEDRGTDEHLEKASLS---------------NNECGFLDKTSAEML-NSNNDA
IKKALISSK-KTSIECASSTENSSVIS--SSLISNA--------AVSGTP-PHPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VKNNQETMIKTDSPPQSKQREGTFS-
-------------KSDSEKIVTGTKRSS-----RRAGKAE-------QTGNKRSKPIMK-
------------SEKEKNTEESIEGMV-VLEN-NSPGLLNQTECVSDN-QVHLS-ESTME
HDDAKLKA-AMETVVLLETNTIEEKNVEINLESKENTPPIVMPA-DQMVNEDSQVQ-ITT
NQKTLRRSSRRRSEVVESTTDSQDKENSHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--IEENLIEKGNNFHEKTPGETS----------ANAEIEQNKKKPEPENIKSEGD
N-IQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKNNESVD-VQDQEEKVVKQECIKAENQSHDY---------KASSE
EN--I--KPQICEKRDEGSTITYQDS--TVTSDLLQVPDDLP-NVC----EEKNKTSKCA
EYS-----FASLTVPESNLRTRNAIKRLHK----RDSFDNCSV--GESLKMGTSDISSLS
EKTFQTLECQHKRS-KRVRRSKSCDCCGEKSQPQE--KSLIGLKNTEDNDVEINETKKAD
VQTPIVTSET-SQANPDSEGQFLD-EHHSVYFHLGLKEDNDTVHDSLIVSETKLKENTM-
-QESPPPEIINFTEE--TCDKDSSDAVSLES-------QESSNENFK-IVGSCLGDSKNA
SQE---SLETKE-------KLEETS---K-KELSLEN-V-TVEGSAGKV-----------
TESNLEKV-ETMELDVGN-------EASFP-EQESTKTDIS-----------EEAV----
IEEN-NTNDESEADTG-KLN-AKEAASDEFNSGISLSDNITPIKLN--------------
--------AQTEISEQTAVGELGGGSDVYDPHSSEKTN-TEIENYEEMMIGEAKAETGPD
DKTENEDITTKTS-KSDEAETNMLNAEMDTFV----RDTVEMSPEEGII----DSNKTEI
NTECNKS-E--EKLGNSQMIRESD--ILQEDY-T--SEKVEEPSQSLTSGTAISELIIE-
DNNASPQKPRELD--SSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTAQ
SQHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGMENKSLSPDEERLG-----------------------S
DTVDTVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPPHENSV--------------

------------------------------------------------------------
----------------------------MTARGQGPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLLRLYKLLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANIQELFSKLNDIV-KSPDKNVRTRALWVISKQTFPAEVIGKMV---
--------------------------PSIIDSLEILFNKGEMHSAVVDFEALNVII----
------RLIEQAPIQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLKKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQNTISIDSNA-LPQGNSSRVATSPGLNPMTPV
HKGASSPYGTPVTPRMNLSSNLGGMAAIPSIQLLGLEMLLHFLLGPEVLNFAKHNKLVLS
LEPLEHPLISSPSFFSKHANILITAVHDSFVAVGKDA--SDAVVNAIWKELISLVKSVTE
SGNKKERPGSEVLTLLIKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLTF-N-SLLECGIADERFFLNLEALVSCVLSGPTSPLAF
SDSVLNVINQNAKQVENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYSALI
LPINHIFSVQKFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELCSKIMSSLED
EGLSNLLFLDRIIHIVTVMFDCIDFSPYDIKYQPKVKSPQRPSSDWSKKK-NEPLGKLTS
LFKLTVRVIYSFHTLSFKEEHSD----TLFAIGNSITSILSSVLGRISLPSMIRKIFATL
TQPLALLCEN-SK--LDEVPKVYSFLNNKLEKLLGEIITCLQFVYTGTYDSELLEQLSPL
LCITFLHKNKQIRKQSAHFWNATFAKVTVLIYPDELKPVLRQAKQKFLLLLPGLETVEMM
E-ESSGPYSDATENSQLNVKISGM--ERKSSGKRDSFLVQTKDKKE-KMK-------PPA
KLKFESSSLKVKSE-ILLEEEKSTDFVFISPEGKNAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-SQY--SQEESIEI--PTLTRKPKEDSKMMF-------KEEQMESDSV
--IPQDVTENCGMDEHLEKASFS---------------NKECGSVYENTSKIL-SSNNDA
RKKALIPSK-KTSTECASSAESSVVVS--SSSVSNA--------TISGAP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLNDMSSTVT----VKSNQENKIKTDIPPKAKQREVTLS-
-------------KSDSEKTSNGTKRSG-----RRLGKAE-------QTGNKRSKPLMK-
------------SEEEKNIQESIEGMV-TLEN-NPPDLLNETECVSDN-QVHLS-ESTVE
YEDAKFKP-TIENAVLLETNAVEEKNVKINLESKENTPPAVIPS-DQMINEDSQAQ-ITP
NQKTLRRSSRRRSEIAESTTDSQNKENNHQKRERRKEEEKP-LQKNPLHIKDDLLPKQKL
ISEQL--MQENLTEKGNSIHEKNFGETS----------ANSEIDQNKRKPDLENIKSEGD
S-AQDIADKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------SKSNDSVD-IEDQEEKMVKQESIKAENQTHDY---------KASSE
VDVDI--KSQVCEKKDESSTAVLEDS---ASSDLLQISDDVA-NTC----EGESKTSKCA
EYF-----FTSPPVPESNLRTRNASKRLHK----RDFIDNYSV--EESSKIETSDISLLS
EKSLQTLECQHKRS-RRVRRSKSCDCCGEKSQPQE--KSFFGFKNTENYDVKISETKKTD
VQTPVTISET-SKANLCSEVKFLD-EHHSVNFHLGIKEDNDTINDSLIVSETELKENTI-
-QETLPSEIVNFKEE--TCGINSSEVKSLQS-------QEPPNKKFK-TVGPCLADSKDI
SQE--CSLETK-------EKPEATV---E-RELSVGNVV-NVEENACNV-----------
TESDLQKI-EAMELDIRN----DKSEASFS-EQESAKTDIS-----------EEAT----
TEENSSSGDESEAETAKKLY-AKEAATEEFNSGISVSDNTTPITVS--------------
--------AQTEMSEQTAVGELDGGSDVPDSGSSEDMN-AEMENCEETVIGEVNAETGYV
NKTEDEDMSIKTS-EPEDAETKGLNAEIDNIV----PDTLEVSPEEGKV----DCNKTET
NTELSKPEE--IKLDDNQMVVGND--ILQ-EVHT--SEKVEEPPQSLTSETGISELIIE-
DNNASPQKLTELD--PSLVSANYSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIIRSH-SSNSSPIVKS---VKTSPTAQ
SKHNTTSIKGFLSPGSRSPKFKSSKKCLITEMTKESMPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DLIDPVNLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWKSPAHENSI--------------

------------------------------------------------------------
--------------------MDGADSTTEASSSGQSLQPLIETLEDPAAGTEVLTDALLA
-----------LTNRLTGEEGKEFAAQVGKHFPQLCKIFKTHIPTENSELSSAALQALGF
CVFNSKIASLLCESEIQELLSVVNSVAERAVDKNTRTRALWVISKQSFPADVVGKLV---
--------------------------PSIITTLETVLNKGDLPSIVVEYEVLNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPSSMEKEAVRWAKLIIPLVVHTAHKVQLKGATALEMGMPLLLQKQQEV
AVVTEVLMTTKIIPELQKLFSSKNETYVLKLWPLFVKLLGKALHRSGSFINSLLQLEELG
FRSGSPMVKKIAFIAWKSLIDNFALNP----EILCTAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGSQLPAHFEQVCVPLIQSTLSLDAS--FVQGNSSRLSINQSLMTPGSA
QKGG-----AAATPKMKLNSRIGGIVALPSIQLLGIEMLLHFFMSPDVLKFANENNIVLS
LEPLQYSVISSPSFFCKHSNTFINAVQDGFIAVGKDA--SDVILSAIWKKMIGFVRAAIE
SGSKKERPSSEVLTMLLQALKSIVLSNELPVLQSLSLIEITVKDLPPKVLGSPAYQIADM
DLLN--------GTPALFLVQLFF-QENVLKCCVQEERFFLNYESLVRIVLSGPTSPLAF
SESVFTIVNQSAQYLENKEHLWRIWSTVVNPLTEWINQTNEVNQGDALEHNFSAVYSALL
LPIKHIFPSTEFPQPTLKTLLRSWSELYRAFARCALLVATAEDNLYCDELCAKIISGIED
ETQINQSMLDGLSHIVSMMVNCISFAPYGTKYQPPNRSPQTL-SDWSKKKKDDPLGKLSF
LVKLLVIMVNALYRLDSKESGLE----KLAPIGVSIIGVLQNIISRISLPSVIRSLFRNV
TKPLAAFYEK-TK--SAKVSRVSNGLNNKFEKLFVESTSCFQSYYTEAFDSELLQELSPI
LCILLLSKTKQIRSQAAQFWNATFGKAVMLAYPEELKSVLDQARHKTILSLPGFESISMA
A-ESTETCSDSVESSQWDPVVSGI--EVNSTGKRDSLLAQTSEVK----ENSITPHVTPA
KMILEFPQLKTNKKTILLEEENTADFVFIPPE---TKERVLTDHQKEVLRTKRVDIPTMY
N-NLDASQDTALFSQYSQSQEESLEV--DVKEEHGKKENETES-------QDEKVTSELP
-DAPCEVTEKCKTQGPPEEIATTTTTNTTEQHEK----MNLDPNCKESEMG---------
---VTK---TVSAEPDVTLNENTSNIS-SSSSSSSD--------VISGTP--QPVSRRQS
FITLEKFDSSE--IRPFSPSNFSHTSGPSVSTLLLSSKQESMATSDDSP-KGSPTLDNKD
NYQVKRGGGQIRTKRSFHEIIDALENYVKVKKAKEESKLNSQLRSASTLGIKKSSLRKNQ
AELSEDKTKQTEQDQEKN-TAIPAVE-------HVEEKPEVPCETQEAASSLNTTDKT--
---AENKQ-TLDNVAE-T------KVEPNLDSTKENTPPVIDAP-GEAISNVSQAPQISP
SQKTLRRSLRRKPETMEESADSQEKGS--QQKKDGHKDDEK-LPKKSPQGKEIVIQKSVP
E--KTMDTR------RGGIHGSNTADVIVTDECQTSRNSQEKGNKSTGKTEGNNSASDID
NLQVSAPDATEEKP-KDHPRYHTRRSSQGLLTRIENSESESSETREEGTKRKRESESSET
REEGTKRKRSERLKNKTSS-FG-NNVKED-LESQ--DVHSQSVVEIQNISIENKEMILPE
CHVNLSLITGNCKEKDK-N--------TLQVSECLENKQDMDTPLYRETSDEDKNSDKSM
TE--------------SSLEIEEGSNILDTDSVLCSSKRNLTDVSGDDVCT-T-AVSLGS
SEKTEMPECQHKRS-RRARKSKNCDCCETSYVLLVR----SDLKKPGTPELRSKEPKKTP
NKATVASPSVSAEEPSSAESLTAV-P-CATSTPVPFVKDFAEQKDSRSVES-----DRDL
SEDEAP--KEEPSNV--PCGKIEGDNSIVE--------EE-SHN----------------
-------------------------------------------------L----------
SCIQSEGDRPIAEKVSE-----SSSPETH--SKESIAPCPS-------------------
----E--VDTVPAALKKEVT-NHSDELEEAV-----------------------------
---------------------------------------------------------MDV
---------------------NQL---EGEQSSESVASVVQNAM-EE---AAAACATMLP
E---------------------PQTEAGQKEHAESAAAEMSFG--CQT---SAPGQISN-
SNSDSPLKSEELDA-LSLAKMDESPNG--M-QARCVWSPSASPSSSILKTGVKRQ-QEED
SP-PVNK--SRRVSFANPIYQEELADDIDRRP-VVRNH-YCNGSPSVRN---IK-SSPSP
IKPITTPTKGSLSPGTRSLKYKSSKKCLIAEMVKEPLPAPT-ESIYPALAGCKTPIDTIL
PQITSNIWARGLGQLIRAK-NIRTVGDLSSLSAAEIKTLPIRSPKVSNVRRAL-KGYHEQ
QIKSHGPEETAGQEDTEKLVNGMDEKPCSTSDDKT-----------------------MA
DLCEPVALRADEQSAIDLWAQINTFTAQMTSENLLSYSGEELIEMIEKLNNTTNCIMKHL
QSRWKSSAQESTV--------------

------------PCWIGSSLSRQAYPSPARSCARPRGHLGPRVAERPACEAVEVRAGLGG
GLALGLRGAVSIGHRLFSSSGPCLRVADMTAPGHSPLAPLLETLEDASASLGEQTDAYLS
-----------LTSRMTGEEGKDVITEIEKKLPRLYKVLKTHISSQNLELCSAALQALGF
CLYNPKITSGLSETNSQELLSKLNDIV-KTSDKNVRTRALWVISKQTFPGEVVGKVV---
--------------------------SSIIDSLEIVFNKGEMHSAVADYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEV
ASITEQLMTTKLISELQKLFMTKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTESLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNV-SPQGNSSRVSPSPNLSPVTPV
HKEVTVYIS-TLVILLNITERLFFLFYTPPHSLLAIFSLCPFTVRSSVCLYXKQNKLVLS
LEPLEHSLINSPSFFGKHANTLITAVHDSFVAVGKDA--SDLVVNAIWKELINLVNSVIE
SGNKKERPGSEVLTLLLKSLESIVKSEAYPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVADERFFLNMETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSIIVNPLTELINQTNEVNQGDALEHNFSAIYGALI
LPINYIFLEQTFPMATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
ETLSNLLFLDRIVHIINVMVDCIDFSPYNIKYQPQVKLPQTP-SDWSKKK-KEPLGKLAS
LFKLIVRVIYSFHTLSFKEVHSD----TLLTVGISITSILSNVLGHISLPSMIQKMFATL
TRPLALLYEN-SK--CDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGIYDSEFLEQLSPL
LCVVFLHKNKQIQKQSAQFWNATFGKVNLLFYPEDLKPVLRQAKQKFLLLLPGLENVDAV
E-ESSGSYSESTENSQLNMKISGM--EIKSNRKRDSLLAQTKDTKE-NMK-------TPA
KLKLES-SPKINSE-VLLEEEKSTDFVFIPPEGKEAKERILTEHQKEVLKTKRGRIPAMY
N-NLDVSQDTLF-SQL--SQEESMEI--PTLIEKPKEDCKMMS-------KEEQMKSS-T
--IPQDITENCGTDEHLVKASLS---------------NIESGSIEETNPEILSS-DNDA
RKQVLLSSK-KTSPDSMSSAENTFAVC--SSSASHA--------TISGMP-PQPTSRRQT
FITLEKFDGSE--SRPFSPSPLNNMSSPIS----VKNNQENMTKTDIPLKAKKREVTPS-
-------------KSDSEKIVKGVKRSC-----RRSSKAE-------QVGNKKSKPLMR-
------------SEEEKISQESTDGIG-TLEN-NSPDLLNQTECISNN-QAHLF-ESATE
SEDTKLES-VVENTVLLDNNTVEEKNLGINLESKENTPPVIIPA-DQLVNEDSQAQ-ITQ
NQKTLRRSLRRRSEIVESTSDSQDKENNHQKKERRKEEEKP-LQKSPLHVKDDVLPKHKL
ITEQT--VLENLIKKENNFHEKTLGETS----------TNTEIDQSRRKPEVENTKSDGD
G-AQDTADKSSEKPIRGRTRYQTRRASQGLLSSIENSESDSSEAKEESSRKKRCGKWK--
--------------SKSNNSVD-NEDQEEQMVKQECVKVENQTCDD---------KASSE
VDIDI--VSQTCDKQGDSSTEILKDS--AGSSDLLQVSDDVP-STH----EEKSKINTCA
EY-------SSPPVPESNLRTRNASKRLHK----RDSIENNSV--GESSRTETSDFSLPS
EKPLQTLECQHKRS-RRVRRSKGCDCCGEKSQLQE--KTLIGLKNTENYDLKISETKKID
LQLPITMPET-SKVNLYSEVKFSH-EHHSVNFHLGLRKEENSAIASLIVSETELKEDTV-
-QESLSPETANFKEE--TCGIDCSGAGALES-------QEPSNKNFK-TVGPCIGDSEDN
SQD--SSLEVKE------EKPKATL---N-KELSPESLV-SVEASACKV-----------
KERNLEEV-EAMELDVKS----EKSEASLP-ELKCAKIDIS-----------KEEA----
TEEK-NENDDSKADTADELS-AGEAATEEFNSGVDHSDTTTAVKVG--------------
--------DITEISEQIAVGEQDRGSDESDSGSSDEVN-AKVENREEAVFTEMNAETDGC
TEAEAGDMISKTS-EPEETETKKLRAEIDTSF----PDTLEMNTEEGKI----VSSKIET
STQLHQSEETETELDAKHIVMESE--EIL-DHCT--LEKVEEPSQSPIP--EISELITE-
DNNASPQKLKELD--PSIVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
IASPINK--VRRVSFADPIYQAGLADDIDRRCSIVRAH-SSNSSPVVKS---VKISPTAQ
LKHNTTSIKGFLSPGSRSPKFKSSKKCLITEMTKESVPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPAFDISEKTVNGIENKSLSPDEERLA-----------------------S
DLIDPVALE--TPLSKNLVAQISALALQLNSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
TPISKNTFFSNPL--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDSSASHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSEL-------------------------------------------------
------------------------------------------------------------
------S

PF12231 // ENSGT00390000012204_0_Domain_1 (308, 504)

LIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTAKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGSPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLLRLGPHLPANFEQVCVPLIQSTISIDCNA-SPQGNSCRVTTSPGLTPMTPI
NKGASSPYGAPGTPRMNLSPNLGGMATIPSIQLLGLEMLLHFLLAPEVLSFAKQNKFVLS
LEPLEHPLISSPSFFSKHANTLITAVRDSFVAVGKDA--PDVVVSAIWKELINFVKSVTE
SGNKKERPGSEVLTLSLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVADERFFLSLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRTFARCAALVATAEENLCCEELSSKMMSSLED
EDFSNLLFVDRIIHVITVMVDCIDFSPYDIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKAIYSFHTLSFKEAHSD----TLFTIGNSVTSIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SE--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEHLSPL
LRIIFLHKNKQIRKQSAQFWNATFAKVTMLVYPEELKPVLRQAKQKFLLLLPGLETVEMM
EEESSVSYSDGTENSQLNVKISGM--ERKSNGRRDSFLAQTKKKKE-SMK-------PAA
KLKLESSSLKVKSE-ILLEEEKSADFVFIPPEEKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLL-TQY--SQEESMEI--PTSTRKPKEDSKMTI-------TEEQMDSDIV
--IPQDVTEDRGTDEHLEKASLS---------------NNECGSLDKTSPEML-NSNNDA
RKKALISLK-KTSVECASSTENSSIIS--SSLVPNA--------AVSGTP-PHPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMLSTVI----VKNNQETMIKTDCPPKAKQREGTFS-
-------------KSDSEKIVTGTKRSS-----RRAGKTE-------QTANKRSKPIIR-
------------SEQEKNTEESVEGMV-VLEN-NSPGLLSQTECVSDN-QVHLS-ESTME
HDNTKLKA-TMESVILLETNTVEEKNVEINLESKENTPPVVIPA-DQMVNEDSQVQ-MTA
NQKTLRRSSRRRSEVVESTTDSQDKENSHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--IQENLIEKGNNLHEKTPEETS----------ANAEIEQNKKKPDPENIKSEGD
S-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKNNESVEHFQDQEEKVVKQECIKAENQSHDY---------KASSE
ENINV--KPQICEKQDEGSTTMYQDS--TVTSDLLQVPDDLP-NVC----EEKNKTSKCV
EYS-----FASLTVPESNLRTRNAIKRLHK----RDSSDNCSV--GESSKMGTSDLSLLS
EKAFQTLECQHKRS-RRVRRSKSCDCCGEKSQPQE--VSLIGLKNTENNDVEINETKKAD
VQTPVVTSET-SQAIPDSEGQFLG-EHHSVYFHLGLKEDNDTVNDSLIVSETKLKENTM-
-QESPLS-DINFREE--TCDKDSSEAMSMES-------QESSNENFE-TIGSCLGDSKNA
SQE---SLETKE-------KLEETP---Q-KEVSLDN-V-TVEGSICKV-----------
TESNLEQV-ETMELDVGN-------EASFP-EQENTKT--------------EEAA----
IEEN-NTIDESEADTA-KLN-AKEAASDELNSGVSLSDNTTPIKLN--------------
--------AWTEISEQTAVGELGGGSDVYDPYSSEKMN-TEIENYEETMIGEAKSETGHD
-ETENEDITTKTS-QFDEAETKMLNVEMDNFV----RDTVEMSAEEGII----DSNKTEI
NTECSKS-E--EKLDNNQMIRESD--ILQEDH-A--SEKVEEPSQSLTSGTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTAQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGMENKSLSPDEERLA-----------------------S
DTVDTVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGTMANSIMKNL
QSRWKSPPRENSV--------------

------------------------------------------------------------
----------------------------MTAADQSPLAPLLETLEDPSASLGEQTDAYLT
-----------LTSRMTGEDGKEIITEIEKKLPQLFKVLKTHIASQNSELSSAALQALGF
CLYNPKIASGLSEINIQELLSKLNDIV-KSSDKNVRTRALWVISKQTFPTEVVGKVV---
--------------------------SSIIDSLEIVFNRGEMLSAVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESIRWAKLVIPLLVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGSSSRVATTPGLSPMTPV
HKEGASPYGTPVTPRMNLNSNF-GMATIPSIQLLGLEMLLHFLLGPEVVSFAKQNKLILS
LEPLEHPLISSSSFFSKHSNTLITAVHDSFVAVGKDA--SDVVINAIWKELISLVKSVIE
SGNKKERPGSEVLTLLLKSLESIVNSEVFPVLKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLTF-NNNLLECGVEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVVNQNAKQLDNKEHLWRMWSIIVTPLTELINQLNTLKSDNIGKHNFSAIYGALI
LPINHIFPAQKIPVVTMKTLLKTWSELYRAFARCAALVATAEENLCCEEFCSKIMSSLED
EGLSNLLFLDRITHIITVMVDCIDFSPYNIKYQPKTKSPQRP-TDWSKKK-KEPLGKLAS
LIKLIVRVIYSFHTLSLKEVHSD----TLLTIGNSITSILSNLLGHISLPSMIQKIFAAL
TRPLALFYEN-SK--LDEVPKVYSCMNNKLEKLLGDIIACLHVSYTGTYDSELLEQISPL
LCIIFSHKNKQIRKQSAQFWNATFAKVTMLIYPEELKPILKQAKQKSLLLLPGLENVEIM
E-ESSGPYSDMTENSQLNMKISGM--ERKSSGKRDSFLAQTKDTKD-SMK-------PPA
KLKLDSSTPKAKGE-MPLEEEKSTDFVFIPPEVKETKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFS-QY--SQEESMEI--STLIEKSKEDSKMIF-------KEEQKENDIV
--VPQHVMENCGMDEHLEKASLL---------------NNECGSIEETSPKILSS-NNDA
RK-KALIAS-NKPTECASTTENPSGVS--SSSVSIA--------TISGAP-LQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSTVI----VKSNQEGMGKTDNPSKAKKREVALS-
-------------KSDSEKITHGTKRSS-----RRSSKSE-------PIGSKKSKPLMR-
------------SEQEKSTQESVDGTV-ALEN-NPPGLLNQTECVLDN-QVHLS-ESTVE
FEDTMLES-TVENTV-LENNTVEERTLEVNLESKENTPPAII-T-DQTVNEDSHIQ-VTP
NQKTLRRSLRRRSETAEPTTDSQDKENNHQKRERRKEEEKT-PQKSPLHVKDDVLPKQKL
ISEQS--VQGNLVDKGNNLHEKAFGETS----------ANAEIDENRRKPDLENTKSEGD
G-VPDIADKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKSSDNVD-MEDQEEKMVKQECIKIENQAHDY---------KGNPE
VDKDI--KSQICEKGDESTTVSLQDS--TVSPDLLQVYDDVL-NTS----EGESKSNKDA
DHS-----FSNPSVPESNLRTRNASKRLHK----RDSIEN-SM--GESSKIGTSDISLLS
EKTLQTVECQHKRS-RRVRRSKGCDCCGEKSQSQE--KSFTGLKDTENYDVKVSETKKTD
GETPVSISET-SKADLSSEVKLLD-EHHSVNFHLDLKEENDTTNDSLIISETELKENTT-
-QSFLPSEMVKFKET---SRRDSEEAISLET-------QEPSNKKCK-TVDPHLDVSKDI
SLK-CFSLETKE------EKSEATS---KEKLS-TENIV-IVESN---------------
AESNPE-V-DAMELNVEN----DQSEAGFS-EQKNVKT----------------GI----
PGKEVTEENSERMDTPEKLK-ANEAVTEEFNSATDYSDTPTSVKVN--------------
--------AQVEISEQIAVGELGGGSDESDPGSSEEMN-AEMKNCEKTAVCEVTTESDHV
TETEDEDVTTT-ASLPIEVETKELDVEVNNFV----PDTLEMITEEGKV----DPNKTET
NTEPNKLEE--TQLDDNQMVVESN-ETLPEVHHT--SEKVEEIAQPLTSETDISGLISE-
DSNTSPQKSKDID--PLLMSANESPSG--M-HTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIVRCH-SSNSSLMVKS---VKTSPTVQ
SKHNTTSAKGFLSPGSRSSKFKSSKKCLIAEMAKESVPCPT-ESVYPALVNCVAPVEIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTINGMENKSISPDEERLA-----------------------S
DLIDPVALE--APLSKNLVAQISALALQLDSEDLYNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSF--------------

------------------------------------------------------------
-----------------------------DGPGSEPLAPLLET-EDPSASHGEQTDAYLT
-----------LTSRMTGEDGKEVIVEIEKKLPQLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSGLSEKNIQELLSKLNDIV-KSSDKNVRTRALWVISKQTFPTEVVGKVV---
--------------------------SNIIDSLEIVFNRGDVHSAVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESIRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTESLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTVSIDSSA-APQGGSSRAAPSPGVNPGTPV
HK-GASAYGSPVTPRMNLNSNFGGMATIPSIQLLGLEMLLHFLLGPEVLNFAKQNKLVLS
LEPLEHPLISSSSFFSKHANTLITAVHDSFVAVGKDA--SDAVVNAIWKELISLVKSVIE
SGNKKERPGSEVLTLFLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILNA------RGTPALFLIQLIF-NNNLLKC-VEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSVQKFPVTTMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGLSNLFFLDRIIHVITVMVDCIDFSPYNNKYQPKVKSPQRT-SDWSKKK-KEPLGKLAS
LFKLIVRVICSFHTLSLKEVHSD----TLLAVGSSITSILSNVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDELPKVYSCMNNKLEKLLGEIIACLHFSYTGTYDSELLEHISPL
LCITFLHKNKQIRKQSAQFWNATFAKVTMLIYPEELKPVLRQAKQKFLLLLPGLENVEIT
E-ESSGPYSEGRENSQLNMKISGM--ERKSSGKRDSFLTQTKDTKG-NMK-------PPA
KFKPE-STPKTKSE-MPLEEEKSVDFVFIPPEGKEAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDALYS-QY--GQEESMEI--PTVIEKSKEDSKVMF-------KEEQMESDIV
--IPQDVTENCGMDERLEKASLS---------------NNGCGSIEETSPEVLDS-NDAG
-KKALISSK-ETSSECAASAENTFGVS--SSSVSNA--------TISGTP-LQPTSRRQS
FITLEKFDGSE--NRPFSLSPLNSMSSTVT----VKNNQEDTTKADTPLKAKGREVALS-
-------------KCDSEKIVHGIKRSS-----RRSNKAE-------QTGNKRSKPLMR-
------------SDQEKNTQEFIDGVA-ALEN-NPPGLLNQTECILDN-QVHLS-ESTIE
CGDTMLRP-TMENAILLENNTVEEKTLGANLESKENTPPAAIPA-DQMINEDSHVQ-ITP
NQKTLRRSLRRRSETAEPTTESQDKENNHQKKERRKEEEKP-LQKSPSHVKDDVLPKQKL
ISEQT--IQENLVEKGNNLHEKTFGETS----------TNAEIDENRRKADLENTKSEGD
G-AQDVADKSSEKPVMGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSSDSVD-IEDQEEKMVKQECIKVEKQTDDY---------KGNSE
VDIDI--KSQICEEKDKSSTITLQDS--TISSDVSQVSDDIS-NTY----EGKSEANKCS
EYS-----FSNLPVPESNLRTRNASKRLHK----RDSIENNSV--GESTNAVTPDVILLS
EKTLQTPECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSFTGLKNIENYDIKVSETKIPD
VQTPEAISET-SKANLYCGVKLLD-EHHSVNFNLGLKEENDTTNNSLIVSETELKENTI-
-QDSLPSEIVNFTEE--IYDTDSEEAVSVES-------QELSDKKCK-TVGPCLSDSKDI
SLE-CSTFETKE------EISEAIL---K-KEPSIENSV-NIEANACKL----------K
AESNPEGV-EGMELDVET----DKSEVSFS-EQKSAGG-----------AVSEERI----
TEENCERSDESEADAGEKLN-AEEAVIEEFNSVIGHSDN-TPVKIS--------------
--------EQTAVGEQTAVGELSGGSDESDLGSSEERD-AEMEHCEETVISEVNAETDHV
NETEDGDLTSK-ASKPVESETERLNVEVDRAV----PNTLEVSTEEGKV----DC---ET
NMKLNRSEV--TKLGDSQMVVRND-EILQEIP-T--LEKMEETAQSLKSKTTISELATE-
DNDTSPQKLRELD--PLLMAANDSPRG--M-QTRCVWSPLASPSTSILKRGLKRPLQEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSV-RSH-SSNTCLIVKN---VKTSPTAQ
FKHITTSTKGFLSPGSRSPKYKSSKKCLIAEMAKESMPCPT-ESVYPALVNCLAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RVYHEQ
QVKSRGLEEIPVFDISEKTVNGIENKSLSSDEDRLA-----------------------S
DLINPVALE--TPLSKNLVAQISALALQLNSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAQENSV--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KNSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETRSAVVDFEALNVIV----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHALSFKEAHSD----TLFTIGNSITSIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSSLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LRIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NMK-------PAA
KLKLESSSVKVKGE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEEPMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDCGMAEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDE
RKKALISSR-KTSTECASSTENSFVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SEPEKNTEESVEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESTME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQRKERRKEEEKP-LQKSPLHIKDDVLPKQKL
IAEQT--LQENLIEKGSNLHEKTLGETS----------ANAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSE
EDVSI--KSPICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NVC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDISLLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLIGLKNTENNDVEISETKKAD
VQAPVSPSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIVSETKSKENTM-
-QESLPSGIVNFREE--ICDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETKE------GKPEETP---K-MELSLEN-V-AVEGNACKV-----------
TESNLEKA-KTMELDVGN-------EASFH-GQERPKTGIS-----------EEAA----
IEENYKINDDSEADTA-KLN-AKEVATEEFNSDISLSDNTTPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDLHSSEETN-TKMKNYEEMMIGEAMAETGHD
GETENEGITTKTS-KPDEAETNMLTAEMDNFV----CDTVEMSTEEGII----DANKTET
NTEYSKS-E--EKLDNNQMVMESD--ILQEDYHT--SQKVEEPSQCLASGTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPPLVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIANKSLSPDEERLV-----------------------S
DIIDPVALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------MQELLSQLNDIV-

PF12231 // ENSGT00390000012204_0_Domain_1 (209, 504)

KSSDKNVRTRALWVISKQTFPTEVVGKMV---
--------------------------SAIIDTLEIVFNKGEIHSAVVDFEALNVII----
------RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTIS-DSSA-SPPGNSSRVTASPGLSPVTPV
HK-GASPYGVPVTPRMNMSTSLGGMAAIPSIQLLGLEMLLHFLLGPEVLSFAKQHKLVLS
LEPLEHPLISSPSFFSKHAHTLITAVHDSFVAVGRDA--SDAVVNAIWKELISLVNSLTE
SGNKKERPGSEVLTLLLKSLESIVKSEVLPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-SNYLRECGTADERFFLNLESLVGCVLSGPTSPLAF
SDSVLSVINQNAVQLENKEHLCRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYSALT
LPINHIFSAQRFPVVTMKALLRTWSELYRIFARCAALVATAEENLCCEELSSKIMSTSED
AAFLNLLFLDRIIHIITVIADCIDFSPYNNKYQPKVKSPQRS-SDWAKKK-KDPLGRLAS
LFKLIVKVIGSFHTLSFEEAHSD----SLLGIGSSVISVISSLLGHISLPSAIRKIFTVL
TRPLALFYEN-TN--LDEVPKVYSSLNNKLEKLLGEITTCLQFS-AGTFDSELLEQLSPL
LCIIFLHRNKQIRKQTAQFWNATFAKVAMLTYPEELKPVLREAKQKFLLLLPGLENVEIM
E-ESSGSYSDTTENSQLNMKISGM--ERKSNGKRDSFLAQTKEKKE-NMK-------PSA
KLKRESSSPKVKSE-LLLEEEKSTDFVFIPPEGKESKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFTDCY--SQEDSIQT--STLTEKPKEDTKMVI-------KEEQVKSDTV
--V-QDALENCGMDEHSKKASFS---------------SNECGFVPKTSPEILSS-NNEA
RKNTLISSK-KTSTECTSSAENSL-VC--SRSVSDA--------SISGTPPPYPTSRRQS
FITLEKFGGSD--TRPFSPSSLGNMSSSVS----VQKTQENMTTTDSTPKTKKREVVHS-
-------------KSDSEKNPNGVKRSS-----RRLNKAE-------KSASKRSKPLIK-
------------SEQEEK-KESVESTV-ALEN-NSPDLFNQTECSSDG-QVHLS-ESVPE
HEDRKPKP-AVENTVLLENSTVQEKNMGINLESKENTPPAVTPA-DQTVNEDSQSQ-VTP
SQKILRRSSRRRSEITDTIGDKQDKENSHQKRERRKEEEKP-QGF--L----HVKD-DVL
PKQQT--GQENLLEKGNYLHEKASDESS----------ANADTDQNKRKSDLENVNSEGG
G-ALDAADKSSEKPLRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSAKLK--
--------------NKSSDSVD-TEEQEGKMVEGESVTVKNHTQNY---------KAISE
VDVEK--RPPVYEKG-ESNAVILECS--TASADKLHVSDDVP-NTC----EGKTKTSESS
EHSLAKVQSTPSSIPESNLRTRNASKRLLK----RDSDSS-SV--GECSRIGTPEISTPP
EKNVQIYECHHKRS-RRVRRSKGCDCCGEKSQPQE--KSSIGLKNTENTEIKSSEMKKMD
VQTPDTVVEAASKAHLCSEVKHLD-EHASVNFNLVLKG-NDTVSENILEPETKSKENTI-
-QKS--SEVVNLEEK--PHERDSGEAVCPVS-------EEPSSKKFK-AVDPCLGDLRDI
SEE--CHLDATE------GKPETPL---KR-ELRV--AN-IEEGNACKT----------R
GGSSTELA-KAMELDAEN----YTSEASVS-EKECIKTDTS-----------EL------
ATEECKSSDRPSAETADKLD-AEEVTAEKFGSGIGLGDNTVPINVK--------------
--------PQTEISEQIAGGELGDRSNESDSASSKQMN-AEVENYEEMVIGHMNHEIGSV
TETEDEDVTAQ--TKLEESKTEQLNAELDSFV----PDTLEMSTEEGRV----ESKKTET
NIELSKSEE--TNLGDSPVAVGSD--VLLEDSHT--PDKTEEPSQSSTSETTISELVME-
NNDSSPEKLRELD--SLLLSANDSPGG--M-QTRCVWSPLASPSTSILKRGLKRL-QEDE
VSSPVNK--VRRVSFADPIYQAGLADDIDRRGPLVRSH-SSNNSPVIKS---VRTSPTSQ
TKHNTTSAKGFLSPGSRNCKFKTSKKCLITEMAKESTPYPS-GSVYPALMNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVRKAL-RMYHEQ
QMKSQGLEEIPVFDISEKTLNGIENKS--ADEERLA-----------------------S
DLIDPVTLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGTMANSIIKNL
QSRWRSPANENSS--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDSSASHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSETNVQELLSKLNDTI-KSTDKNVRTRALWVISKQTFPSEVVGKVV---
--------------------------PSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTA-------------------------------

PF12231 // ENSGT00390000012204_0_Domain_1 (402, 504)

TLHRSGSFINSLLQLEELG
FRSGSPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLLRLGPHLPANFEQVCVPLIQSTISIDCNA-SPQGNLCRVATSPGLTPMTPV
NKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLAPEVLSFAKQNKFVLS
LEPLEHALISSPSFFSKHANTLITAVRDSFVAVGKDA--PDVVVSAIWKELINLVKSVTE
SGNKKERPGSEVLTLSLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVADERFFLSLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRTFARCAALVATAEENLCCEELSSKMMSSLED
EDFSNLLLVDRIIHVITVMVDCIDFSPYDIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITGIISSILGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEHLSPL
ICVVFLHKSKQIRKQSAQFWNATFAKVTMLVYPEELKPVLRQAKQKFLLLLPGLETVEMM
EEESSVPYSDGIENSQLNVKISGM--ERKSNGRRDSFLAQTKNKKE-NMK-------PAA
KPKLESSCLKVKSE-ILLEEEKSTDFVFIPPEEKDANERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTSTRKPKEDSKMTI-------TEEQMDSDIV
--IPQDVTEDCGMDEHLENASLS---------------NNECGSLDKTSPEML-SSNNDA
RKKALISSK-KISIECASSTENSSVIS--SSSVSNA--------AVSGTP-PHPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNMLSTVT----VKNNQETMIKTDCPPKAKQREGTFS-
-------------KSDSEKIVTGTKRSS-----RRAGKAE-------QTGNKRSKPIMR-
------------SEQEKNTEESIEGMV-VLEN-NSPGLLKQTECVSDN-QVHLS-ESTME
HDNTKLKA-TMESVVLLETNTVEEKNVEINLESKENTPPVVIPA-DQMVNEDSQVQ-ITA
NQKTLRRSSRRRSEVVESTTDSQDKENSHQKKERRKEEEKP-LQKSPLLIKDDVLPKHKL
ISEQT--IQENLIEKGNNLHEKTPGETS----------ANAEIEQNKKKPDPENIKSEGD
S-TQDILDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKCK--
--------------NKNNESVD-VQDQEEKVVKQECIKAENQSHDY---------KASSE
ENINI--KAQICEKQDEGSTIIYQDS--TVTSDLLQVPDDLP-NVC----EEKNKTSKCA
EYS-----FASRTVPESNLRTRNAIKRLHK----RDSSDNCSV--GESSKMGTSDISSLS
EKTFQTLECQHKRS-RRVRRSKSCDCCGEKSQPQE--KPLIGLKNTENNDAEINETKKAD
VQIPIVTSET-SQANPDSGGQFLD-EHHSVYFLLGLKEDNATVNDSLIVSETKLKENTM-
-QESP-PEIINFREE--TCDKDSSEAMSVES-------QEPSNENFK-TIGSCLGDSKNA
SQE---SLQTKE-------KLEETP---K-KELSLEN-V-TVEGSVCKV-----------
TESDLDKV-ETMELDVGN-------EASFA-EQESTKTRIS-----------EEAT----
IEEN-NTNDESESDTA-KLN-AEEAASDELNSGISFSDNTTPIKLN--------------
--------ARSEISEQTAVGELGGGSDVYDPHSSEKTN-TEMENYEETMIGEAKAETGHD
-ETENEDITTKTS-KPDEAETKMLNVEMDNFV----RDTVEMSAEEGII----DSNKTEI
NTECSKS-E--EKLDNNQMIRESD--ILQEDN-T--SEKVEEPSQSLTSRTAISELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--IRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTAQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGMENKSLSPDEERLA-----------------------S
DTVDTVALE--TPLSKNLVAQISALALQLDSEDLRNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPPHENSV--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSDVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--ADVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEVAKMMI-------TEEQMDSDIV
--IPQDVTEDRGTDEHPEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVLST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEENETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKKAD
VQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAISLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATKEFNSDISLSDNITPVKLN--------------
--------AQTEISDQTAAGEL---NDVSDPQSSEETN-TEMKNDEEMMIGELKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENFV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MSAPGENPLLPLLETLEDSSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SPGEQTDAYLS
-----------LTSRMTGEEGKEVIVEIEKNLPQLYKVLKIHISSQNSELSSAALQALGF
CLYNPKITSGLSEADIQELLSELNDIV-KSSDKNVRTRALWVISKQTFPTEVVGKMV---
--------------------------SSIIDSLEIVFNKGEIHSAVVDFEALNVII----
------RLIEQAPIQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEHLMTTKLIPELQKLFMSKNETYVLKLWPLFVRLLGKTLHRSGTFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSAIS-DSST-SPQGNSSRIASSPGLNPMTPV
HK-GPSLYGGPVTPRIHISTNSSGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQHKLVLS
LEPLEHPLISSPSFFSKHAHTLITAVHDSFVAVGRDA--SDAVVSAIWKELISLVNSLTE
SGNKKERPGSEVLTLLLKSLESIMKSEVLPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-SSYLQECGIADERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQVENKEHLWRMWSIIVTPLTEFINQTNEVNQGDALEHNFSAIYSALT
LPIHHIFAVQRLPVVTMKALLQTWSELYRVFARCAALVATAEENLCCEELSSKIMSILDD
EAFLNLWFLDRIIHIITVIVDCIDFSPYNTKYQRKVKSPQRS-SDWAKKK-KDPLGKLAS
LVKLIVRVICSFHTLSFKEAHSD----ALLGVGNSIISMISNLLGHISLPSVIRKIFAVL
TRPLALFYEN-SK--LDEVPKVYSSLNNKLEKLLGEIITCLQSC-AGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVMTLNYPEELKPVLREAKQKVLLLLPGLENVEII
E-ESSGSYSDATENSQLNMKISGV--ERKSNGKRDSFLAQTKEKQE-NMK-------PSA
KLKRESSSPKVKRE-MLLEEEKSTDFVFIPPEGKELKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFSDHY--SQEESVQT--PTLTEKPKEDTKMVI-------KEEQMKSDTV
--I-QDALENCGMDEHIEKPSFS---------------NNECGFVPKTNPEILSS-NNKA
RKNTLISSK-KTSTECTSSAENSL-PS--SRSVSDA--------SISGTH-PQPTSRRQS
FITLEKFDGSD--NRPFSPSSLGNMSSDIS----VQNNCENVTTTDSTPKTKKREVMHS-
-------------KSDSEKILNGVKRSS-----RRLSKAE-------RAANKRSKPLIK-
------------SEQEENNQEPVEGTI-ALENINSPDLHNQTECLSDG-QVHFS-ESVGE
HED-KPKP-TVENAVLLETSTVQEKNMGVNLESKENTPPAVTPA-DEVVNEESQVQ-VTP
NQKTLRRSSRRRSEITDCIGDNQDKENSHQKRERRKEEEKP-QSL--L----HVSPKQKL
TSEQT--EQDKLLEKENNLHEKASGETS----------ANADIDQNKRKPDLENVNSEGD
S-ALDIVDKSSEKPLRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKLK--
--------------NKNNDSVN-IEEQE-KMVEKESLNVENHTQDH---------KATSE
VDVDK--KPPVCEKD-ASSPEILQDS--TAATDTLQVSDVVP-NTY----EGNAKTSKCA
EYT-----FASSPMPESNLRTRNASKRLLK----RDSG-N-SV--GECSKTRTSEISVLS
EKNVQTFECQHKRS-RRVRRSKGCDCCGEKSQLQE--KSSIGLKNTENFDIKSNETKKTD
VQTPDTVLETDSKANLCSEAKFLD-ECGSVNFNLVLKG-NDTIND--FVPEIESKENTI-
-QKS--SEIVNLKEK--ACDVDSGEV-SLES-------EEPTNKKFK-AVGPCLGDCKDI
SEE--YHLDTKE------EKPETTL---KK-ELTV--VN-I-EGNACQV----------I
GESNLEGV-KAMELDVEN----NKSEASVS-EKEYVETDTS-----------KV------
ATEECKSSDDPNTETADKVD-VEA-AAEEFYSGVSLCDNTTLINVN--------------
--------TQTQISEQI-GREAGDRSNESDLGTSEEMN-AKMENYEETLIGHMNNEIASV
KESEDEDMTPK--TKSEETKTEQLSAELDSFV----LDKLEMTNKEEKV----DSNKTET
NTEFSKSEE--ANLDDNQMVVGND--ILLEVNHT--PHKVEEPSQSLTSETTISELVTE-
DNNSSPEKLRELD--SLFMSASDSPSG--I-QTRCVWSPLASPSTSILKRGLKRL-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSLVRSH-SSNSSPVIKS---VKTSPTTQ
TKHNTTSAKGFLSPGSRNCKFKSSKKCLITEMTKESMPCPT-ESVYPALMNCAAPVDIIL
PQITSNMWARGLGQLIRANKNIKTIGENGLLTLQ--------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------

------------------------------------------------------------
----------------------------MTAADQSPLAPLLETLEDPSASLGEQTDAYLT
-----------LTSRMTGEDGKEIITEIEKKLPQLFKVLKAHIASQNSELSSAALQALGF
CLYNPKIASGLSEINIQELLSKLNDIV-KSSDKNVRTRALWVISKQTFPTEVVGKVV---
--------------------------SSIIDSLEIVFNRGEMHSAVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESIRWAKLVIPLLVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGSSSRVA-TPGLNPVTPV
HKEGASPYGSPITPRMNLNSNF-GMATIPSIQLLGLEMLLHFLLGPEVVSFAKQNKLILS
LEPLEHPLISSSSFFSKHSNTLITAVHDSFVAVGKDA--SDVVINAIWKELISLVKSVIE
SGNKKERPGSEVLTLLLKSLESIVNSEVFPVLKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLDNKEHLWRMWNIIVTPLTELINQTNEVNQGDALEHNFSAIYGALI
LPINHIFPAQKIPMVTMKTLLKTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGLSNLLFLDRITHIITVMVDCIDFSPYNIKYQPKTKSPQRP-TDWSKKK-KEPLGKLAS
LIKLIVRVICSFHTLSLKEVHSD----TLLTIGNSITSILSSVLGRISLPSMIRNIFATL
TRPLALFYEN-SK--FDEVPKVYSCMNSKLEKLLGEIIACLHVSYTGTYDSELLEQISPL
LCIIFSHKNKQIRKQSAQFWNATFAKVTMLIYPEELKPILKQAKQKSLLLLPGLENVEIM
E-ESSGPYSDTTENSQLNMKISGM--ERKSSGKRDSFLAQTKDTKD-SMK-------PPA
KLKLESSTPKAKCE-MPLEEEKSTDFVFIPPEVKETKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFS-QY--SQEESMEI--STLTEKSKEDSKMVF-------KEEQKENDIV
--VPQHVMENCGMDEHLEKASLL---------------NNECGSIEETSPKIPSS-NNDA
RK-KALIAS-NKPTECASTTENPFGVP--SSSVSNA--------TISGAP-LQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNSMSSTVI----VKNNQEGMAKTDNPSKAKKREVALS-
-------------KPDSEK-THGTKRSS-----RRSSKPE-------PIGSKKSKPLMR-
------------SEQEKSTQESVDGTI-ALEN-NPPGLSNQTECVLDN-QVHLS-ESTVE
CEDTMLKS-TVENTVLLENNTVEERALEINLESKENTPPAII-T-DQTVSEDSHIQ-VTP
NQKTLRRSLRRRSEIAEPTTDSQDKENNHQKRERRKEEEKT-PQKSLLHVKDDVLPKQKL
ISEQS--VQENLVDKGNNLHEKAFGETS----------ANAETDENRRKPDLENTKSEGD
G-VQDIVDKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKSSDSVD-IEDQEEKMVQQECIKVENQA------------QGNPE
VDNDI--KSQICEKREESNTVTLQDS--AVSPDLLQVYDDVL-NTS----EGKSKSNKDA
EHS-----FSNPSVPESNLRTRNANKRLHK----RDSIEN-SM--GESSKIGTSDISLLS
EKTLQTVECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSFTELKDTENYDVKVNETEKTD
VETPVSISEI-SKADLYSEVKLLD-EHHSVNFHLDLKEENDTTNDSLIIPETELKENTT-
-QSFLPSEMIKFKET---SHRDSEEAISLES-------QEPSNKKCK-TVDPNLDVSKDI
SLE-CFSLETKE------EESEATP---KEKLS-TENIV-IVESN---------------
AESNPEVV-DAMELNIEN----DQSEASFS-EQESVKT----------------GI----
AEKEVTEENSERMDTPESLK-VDEAVTEEFNSAADYSDNPTPVKGN--------------
--------AQVEISEQMTVGELGRGSDESDPGSSEEMN-AEMKNCEKTVVGEVTTESDHV
TETEEEDLTTT-ASLPVEAETKGLDTEVNSFV----PDTLEMITEEGKV----DPNKTET
NIEPNKLEE--TQLDDNQMVVESN-ETLPEVHHT--SEKVEEIPQPLTSETGVSGLISE-
DSNTSPQKLKDID--PLLMSANESPSG--M-HTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIVRCH-SSNSSLMVKS---VRTSPTVQ
SKHNTTSAKGFLSPGSRSSKFKSSKKCLIAEMAKESVPCPT-ESVYPALVNCVAPVEIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RMYHEQ
QVKSRGLEEIPVFDISEKTINGMENKSVSPDEERLA-----------------------S
DLIDPVALE--APLSKNLVAQISALALQLDSEDLYNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSF--------------

------------------------------------------------------------
----------------------------MTAAGRSPLEPLLETWEDRSVSP

PF12231 // ENSGT00390000012204_0_Domain_1 (112, 504)

GEQTDAYLT
-----------LTSRMTGEEGKEVITEIEKNLPRLYTVLKAHISSQNSHLSCAALQALGF
CLYNPKITSGLSEENIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPSENVSKMV---
--------------------------SSIIDSLEVLLSKGEVHSAVVDFEALNVIIS--H
QFLYC-RLIEQAPVKMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGIPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPGNFEQVCVPLIQSTISTDSIA-SPQGSSSRGSASPSLSPLTP-
GHKGASPYGAPATPRMNPSSNIGGMASIPSIQLLGLEMMLHFLLGPEVLNFAKQHKLVLS
LEPLEHPLISSPSFFTKHAHTLITAVHDSFVAVGRDA--SDAVVSTIWKELISLVKSVTE
SGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVNIFINLLPL---------------
--L----------QGPLFLIQLIF-NNNLVECGVADEKFFLNLETLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLANKEHLWRMWSIIVTPLTEVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQSFPMATMKTLLKTWSELYRAFARCAALVATAEENLCCEELASKIMCSLED
EVLSDLLFLDRISQIIIVMVDCIDFSPYNIKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVKVIHSFHTLSFKEKCTD----ALLTIGNSIISMISNIFGHISLPSMIREIFATF
TKPLALLYEN-SK--LDEVPKVYSSLNSKLEKLLGEIVACLQYNYSGAYDSELLGQLSPL
LCIVFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKTLLLLPGLENVEMM
D-ESSVPYSDATENSQLNVKISGM--ERKSNGKRDSFLTQTKDKKE-NMK-------LSA
KLKLESSSPKLKSS-KLLEEEKSTDFVFIPPEGKEAKARVLTEHQKEVLKTKRCDIPALY
N-NLDVSQDTLFSAQF--SQEESMES--PTLTENPKEDTKIT--------KEEQMESAVF
--TPQGAVENCGMDEHSEKASLP---------------NDRG-SVAETSSEVLSSG-IDA
TKNTLVSSK-IISAEGSSSAESSPVVN--SSSVSNA--------SVSGT--PQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSTVT----VRNNQENTTKTDMPTKARKREVTHS-
-------------KSDSEKLVNGGKKSG-----RRWSKAE-------QSANKKSKPSLR-
------------SEQEERV----------SEN-NSPDLLSQTECESKN-H-NPS-EAVLE
HEDRTPKQ-IVENA-LLEDSTTEEKNIDIIMESKENTPSVATPA-GQIVNGDSQAA-AAA
NPKTLRRSSRRRSEIIESSTDSQDKDNGQPKKERRKEEEKT-VPKSPLHIKDDKLPKHKV
TAESP--IQENLTEKGGSLHEKTIEEPN----------VNAEIDQNKRKSDHEDVSSEG-
GGTQDNVDKSSEKPLRGRTRYQTRRASQGLLSSVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-IGEQEEKMVQEECVKAANETNDG---------QTVPE
VDVDA--SAQICEEST--NRVLLQKS--TGSSDSLQVTD-TS-DIG----DDSSNTSKCV
DTS-----FASSPVPESNLRTRNASKRLHK-----RDTD--S----------TSDISVPS
EKWAQAVECQHKRS-RRVRRSKSCDCCGEKSLSQE--KSFIGLKNTESCAIKSIET-KTD
MQAPETTPETCDANDEHAETKLVD-EQPIMNFYLGLKEENATTGD-LIRSETGLEDDRK-
-NILL-SEIVNTD----------SGEKVSEI-------QEPCNETFN-AEDPCLSDCKDT
SQK-YSSDN-------------------KEEKFDISGV-----GNVCKV----------I
DGSNSEGI-EAMELDVGD----DSFGDSFS-EQKSGQLDIS-----------VDTA----
TEEDNKK-DEIEAV-TTEVN-GEGTATEGLNSGMGLSDKAAPVSK-I-------------
--------VQT--EHPARVNLEG-------MGSCEEMN-KEMESYKAA----SKTEIDNT
R-EKDRGTIVS-SSTSEEAQVRRLDVQTESSV----CDTPEK-SS-----EGSFCHKIER
NIELNKLDE--TKLSDNPTGVGND--NMQEVCLT---EKVEELPQSLTSEVAS-ELVAES
NNNGSPEKLRELD--SSFGSANESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-HEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSISSPIIKS---VKTSPTSH
SKHNTTSAKGILSPGSQSSKFKSSKKCLISEMAKESMLSPTTESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPVFDISEKAVNGVESKPLSSDEERLA-----------------------S
DLIDPVTLDT--PLSKNLMTQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLT
-----------LTSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KNSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVIV----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVVRDLCFSEN--------------------------IVSSFIISFHN
DLFF--------------------------------------------------------
------FFFFSFS---------------LFFLRQSLT----------------------L
SSSLGVQWCNLSL--LQPLPPG----------------------------------FKQF
SCLSL-----------PSSW----------DYRTMPLPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-SMK-------PAA
KLKLESSSLKVKGE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRFVVFPES
QTRLLVINLC------------------------VYIYVYISV-------QEEQMDSDIV
--IPQDVTEDCGMAEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDE
RKKALISSR-KTSTECASSTENSFVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SELEKNTEESIEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESTME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
IAEQT--LQENLIEKGSNLHDKTLGETS----------ANAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDY---------KASSE
EDVSI--KPPICEKQDESSTVMCQDS--TVTSDLLQVPDDLP-NVC----EEKNETSKHA
EYS-----LTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDISSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLIGLKNTENNDVEISETKKAD
VQAPVSPSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIVSETKSKENTM-
-QESLPSGIVNFREE--VCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SPE---SLETKE------EKPEETP---K-MELSLEN-V-TVEGNACKV-----------
TESNLEKA-KTMELDVGN-------EASFH-GQERTKTGIS-----------EEAA----
IEEK-KRNDDSEADTA-KLN-AKEVATEEFNSDISLSDNTIPVKLN--------------
--------AQTEISEQTAAGELDGGNDVSDLHSSEETN-TKMKNYEEMMIGEAMAETGHV
GEPENEGITTKTS-KPDEAETKMLTAEMDNFV----CDTVEMSTEEGII----DANKTET
NTEYSKS-E--EKLDNNQMVMESD--ILQEDHHT--SQKVEEPSQSLASGTANSELIIE-
DNNASPQKLRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKRSKKCLISEMAKESIPCPT-ESVYPPLVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVALE--TPLSKNLVAQINALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MSALGENPLLPLLETLEDSSAFPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 503)

EQTDAYLT
-----------LTSRMTGDEGKEVVIEMEKNLPRLYKVLKTHISNQNSELSSAALQALGF
CLYNPKITSGLSEANIQELLSELNDII-KSSDKNVRTRALWVISKQTFPTEAVGRMV---
--------------------------SSIIDSLEIILTKGEIHSAVVDFEALNVIIRYVF
------GLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ANITEHLMTTKLISELQKLFMNKNETYVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNS----GSL------------LSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTIS-DSST-SPPGNSSRVAASPGLSPMTPV
HK-GASPYGVPVTTRMNMSTNLGGMAAIPSIQLLGLEMLLHFLLGPEVLNFAKQHKLVLN
LEPLEHPLISSPSFFSKHAHTLITAVHDSFVAVEEDALVNNAVVNAIWKALISLVNSLTE
SGNKKEKPGSEVLTLLLKSLESVVKSEVLPISKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-SCYIQECGIADERFFLNLESLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLENKEHLCRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYSALT
LPINHIFSAQRFPVVTMKALLRTWSELYRIFARCAALVATTEENLCCEELSSKIMSTLED
EAFLNLLFLDRIIHIITVIVDCIDFSPYNNKYQPIVKSPQRS-SDWAKKK-KEPLGKLAS
LFKLTVRVICSFHTLSFKETHSD----TLLGIGNSIINMISNLLGHISLPSVIRKIFTVL
TRPLALFYEN-SN--LDEVPKVYSSLNNKLEKLLGEIVTCLQFN-AGTFDSELLEQLSPL
LCIIFLHKNKQIRKQCAQFWNATFAKVMMLTYPEELKPVLREAKQKVLLLLPGLENVEIM
E-ESSASYSDATENSQLNIKISGL--ERKSNGKRDSFLAQTKGRKE-NVK-------LSA
KLKRESSSLRVKSE-PLLEEEKSTDFVLIPPEGKESKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTVFTDHY--SQEDSLLN--------------------------LKIFNDTV
--I-QDALENCGMDEHVKKASFS---------------NNECGFVPKTNPEIMSG-SNEA
RKNSLISSK-KTSTECASSAENSL-VS--SQSISDA--------SISETP-PQTTSRRQS
FITLEKFDGSE--NRPFSVPSLSSMSSNTL----VQNSQENMTTTDNTSKTNKREMMHS-
-------------KSDSEKNLHGIRKSS-----RRLSKVE-------KSASKRSKPLIK-
------------SQQEE-NQELVE-------ENNSPVFFNQTDCSSDG-QTHIS-DSVPE
HEDRRPKL-TLENTVLLENGTVQDKNMGINLESKENTPPAQPPA-DQIVNEDSQVQ-VTP
NQKTLRRSSRRRSEITDAVGDNQDKENSHQKKERHKEEEKL-QGL--LHVKDDVLPKQKL
TYEQT--GQENLLEKESNLHEKACGETS----------VNADIDQSKRKPDLENVNSQGD
S-ALDIVDKSSERPLRGRTRYQTRRLSQGLLSSIENSESDSSEAKEEGSRKKRSGKLK--
--------------NKNNDSID--TEQEEKITEEESGSVTNHTQDY---------KAISE
IDVDK--KPQVLEKG-QSNTIILQDS--KTSVGMLQVSVDVP-NTC----EERVKTTKCL
ESS-----FASSPMPESNLKTRNASKRSVK----QDSD-N--------------KMSTLS
EKNVQTIECHHKRS-RRVRRSKGCDCCGEKSQPQE--KSPIGLRNTENTDIKSSEI-KTS
VQTPDTVLETDSKANLCSEVKVLD-ERASVSFSLVLKG-NDTINDSVLGPETELKKNTI-
-QKS--SEIISLKEK--ACDTN----------------SEPSNKKFK-AEDPCLENSKDI
SEA--YHLDTTG------ENPETTL---KI----ELNVV-NIKGNVCKA----------R
GESNIEVV-KVTKLDAEN----CESEASVS-EKVCVKNDTS-------------EV----
ATEECKSSVEPSTETGDRQD-VKEVAPEDFCSGVGLCDNTSPINVE--------------
--------PQTDISEQIAGGKLGDQNE-SVTASSEEMN-TNMENSEEIVI----------
--------------NHSEMKIEQLNVELDSFV----SDTLEMNTEEEKI----DSNKTET
NIELCKSEE--TNLDDNQMVVG-N--ILLEVNHT--PDKAEKPTESLTSETAVSELVTE-
NINSSPEKLRELD--SLLMSANDSPSA--T-QTRCVWSPLASPSTSILKRGLKRL-QEDE
ISSPINK--VRRVSFADPIYRAGLADDIDRRCPLVRSH-SSNSSPIIRN---VKTSPTSQ
TKHNTTSAKGFLSPGSRNCKFKSSKKCLITEMAKESISCLT-ESVYPPLMNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKALPIRSPKVSNVKKAL-RIYHEQ
QMKSHGLEEIPVFDISEKTLNGIENKS--ADEERLA-----------------------S
DLIDPAALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSS--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SQGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--SDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEIFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGSSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEIM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGTDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFIVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKLKAATMENAVLLETNTVEERNVEINLESKENTPPVVVST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDSIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSEYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKEAD
AQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKEKTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETMELDVGN-------EASFR-EQETSKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KPN-AKEVATEEFNSDISLSDNTTPVKLN--------------
--------AQTEISDQTAAGEL---NDMSDPHSSEETN-TEMKNDEEMMIGEVKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENLV----RDTVEMSTEEGLT----DANKTET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAPGRSPLEPLLETWEDPSVPPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 504)

EQTDAYLT
-----------LTSRMTGEEGKEVIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGF
CLYNPRITSGLSEANIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPTELVSKMV---
--------------------------SSIMDSLEVILSKGEIHSAVVDFEALNVIIS--H
WFLHC-RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPANFEQVCVPLIQSTVSADSSP-SPQGNSSRGSASPALSPLTP-
GHKGASPYGSP---RGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLS
LEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDA--SDAVVSAIWKELISLVKSVTE
AGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAF
SDSVLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQTFPTGTMKALLKTWSELYRAFTRCAALVATAEENLCCEELSSKIMCSLED
EALSDLLFLDRISHIIIVMVDCIDFSPYSKKYQPKIKSPQGS-SDWSRKK-KEPLGKLAS
LFKLIVRVIDSFQTLSLKETFSD----TLLAIGNSIISMLSNVFGHISLPSMIREIFATF
TRPLALLYEN-SK--LDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPL
LCITFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKEKILLLLPGLENVEMM
H-ESSEPYSESTENSQLNVKISGM--ERKSSGKRDSILAHTKDKKK-KVK-------LSA
KLKLESSSPKIKSG-KLLDEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALY
N-NLDASQDTLFSAQF--SQEESMES--FTLTEKPKEDAKII--------KEEQTENTIF
--IPPDAPGNSGIDEHSENAALP---------------KCGG-SVAETNPETLITG-FDA
RKEALISSK-IMSAESSSSTETSV-VS--SSSVSNA--------TFSGTP-PQPTSRRQT
FITLEKFDSSE--TRPFSPSPLDNMSSTVT----VRNNQDNTTNTDIPPKARKREVTNS-
-------------KSDSENLANAGKKSR-----RRWSKAD-------QSVTKKSKPSLT-
------------SEQEEHS----------SEN-NSPDLLSPTEHVSEN-DGHPS-EATLE
HKDGDPKP-AVESA-SLEDLTTEEKNVGINMESKESTASVVAPT-EQIVNEDSQATALAP
NPKTLRRSLRRRSEAGESCSDSQERESGQQKKERRKEEEKI-ISKSPLRIKDDKLPMQKL
TDESP--IQENLTEKGNTFPERTSGEPS----------VNAEIDQNRRKPDLENVSSEGG
GGTLDNIDKSSEKPLRGRTRYQTRRASQGLISGVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-IEEQEEKMAEEEVKKTANQTHDG---------QAVPD
VDKNA--AAQVCEKSTN-NRVILQDS--AGSADSLQAPP-----TG----EEKNKISKCV
DSS-----FVSLSVPESNLRTRNASKR-LY----KRDTD--S-------NVRVSDSSLSP
EKFTP-VECQHKRS-RRVRRSKSCDCCGEKSQSQE--KSFIGLKNTESYAIKSVEEKKTD
LQVPEAAPETREA-SDHAETKLEG-EQPLGNFHLGLKEETCTTGD-SVKSEAELEDP---
--SLP-SEIVTMKER--TYDP------------------DPCSEKDSAAEDPCLSECKDI
PQR-QLSEN-------------------R--EVDVSDA-----GKACEV----------I
AGSSPEGV-ETMELNVRN----DAFVAAAS-EKSTQMDVS------------VNVA----
TEEDNKK-DECEAV-TTEVN-VEGVATEDFNSSMDLSDTPIPVSK-D-------------
--------VET--EHPASGEIEGDS-NESDSGSCEEMN-KEMGSHKAQ----MSTEIDSA
R-VKETDIFAS-ASKSEEALIGRVDVNTQSFV----SDIEMS-SG-----ERTVNCKTET
SIEL-KLDE--AKLSGNEATVEND--TLQEVCFT--SEKVEKLPQCLLLQVAS-ELGAES
NTT-SPEK-LELD--P-FGSVSESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-QEDE
I-SPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPIIKS---VKTSPTSH
SKHNTTSAKGLLSPGSQSSKFKSPKKCLITEMAQESVLSPT-DSVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFA-----------------------S
DLIDPVTLDT--PLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--SDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEIFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGTDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-PCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKARQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLIK-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESVME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVLST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEVIESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLHEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDG---------KASSQ
EDVNI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGISDVSSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKKAD
AQAPVSMSET-SQANPCSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESPNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TESNLEKV-ETVELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATEEFNSDISLSDNTTPVKLN--------------
--------AQTEISDQTAAGEL---NDVSDPHSSEETN-TEMKNDEEMMIGEVKAETGHD
GETENEGINTKTP-KPDEAETKMLTVEVENFV----RDTVERSTEEGLT----DANKTET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DIIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MSALGENPLLPLLETLEDSSAFPGEQTDAYLT
-----------LTSRMTGEEGKEVILEMEKNLPRLYKVLKAHISSQNSELSSAALQALGF
CLYNPKITSGLSEANIQELLSELNDTV-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEIVFNKGEIHSAVVDFEALNALISLIH
------RLIEQAPIQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEHLMTTVSISLCR-YFLNT--------ALEIQSGLKLTL

PF12231 // ENSGT00390000012204_0_Domain_1 (404, 504)

HRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCIPLIQSTIS-DSSA-SPPGSSSRV-TTPGLNPGTPV
HK-GASPYGIPVTSRMNMSPNLGGMATIPSIQLLGLEMLLHFLLGPEVLNFAKQHKLVLS
LEPLEHPLISSPSFFSKHAHTLITAVHDSFIAVGRDA--SDAIVSAIWKELISLVNSLTE
SGNKKERPGCEVLTLLLKSLESIVKSEVFPVPKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NSYIQECGIADERFFLNLESLVGCVLSGPTSPLGF
SDSVLNVINQNVMQLENKEHLSRMWSIIVTPLTELINQTNEVNQGDALEHNFNAIYSALT
LPINHIFSAQIFPVVTMKALLRTWSELYRIFARCAALVATAEENLCCEELSSKIMSTLED
KTFLNLLFLDRIIHIITVIVDCIDFSPYNNKYQPKVKSPQRL-SDWAKKK-KEPLGKLAS
LFKLIVRVISSFHTLSFKEAHSD----TLLGIGNSIINMISNLLGHISLPSVNRKIFAIL
TRPLALFYAN-SN--LDEVPKVYSSLNNKLEKLLGDIITCLQFS-AGTFDSELLEQLSPL
FCTIFLHKNKQIRKQSAQFWNATFAKVMMLTYPEELKPILREAKQKVLLLLPGLETVEIM
E-ESSGSCSEPTENSQLNMKISGM--ERKSNGKRDSFLAHTKEKK--NTK-------PST
KLKRESSSPKVKNT-LLLDEEKSTDFVFIPPEGKESKEKILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFTDHY--SQEESMQT--PTLTEKPKDDTKMVI--------KEQVKSDTV
--I-QDALGNCGMDEHMKKASFS----------------NECGFVPKTSLEILSS-NNEA
KKTTLISSK-KTSTECTSSAENTL-VS--SRSVSDA--------SISGTP--QPTSRRQS
FITLEKFDSSD--NRPFSPSSLSNMPSNVS----EPKNQENMNTAGNTPKTKKREVMHS-
-------------ESDSEKKLTGVKRSS-----RRLSKAE-------KSASKRSKPIMK-
------------SEQEENNQELVE-------KNSSPDLFNQTECSSDD-QVHFS-ESLTE
HEDKKPKP-TLENAVLLDNSTAQEKNMGINLESKENTPPTVTPA-DQTVSEDSQVL-VTP
NQKILRRSSRRRSEIVVSIGDSQDKENSHQKRERRKEEEKP-QAL--LHVKDDVLPKQKL
TCEQT--GQENLLEKGN--VEKASDETS----------PNADIDQNKRKSDLENVNSEGD
NNTLDVTDKSSEKPLRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKLK--
--------------NKNNDSVD--IEQEEKMVEEESVSIKNHTDDD---------KAISE
VDVDK--KPQVYEKG-EN-TVILKDC--TAYTDTLQLSDDVP-NIY----EGKTKASKSP
ECS-----FASSPMPESNLRTRNASKRLLR----RDSDSN--------------KLPMLS
EKNVQTFECQHKRS-RRVRRSKGCDCCGEKSQPPE--KSAIGLKNTENTEIKSSEI-KTE
VQIPHTLSETDSKANLSSEVKYLD-EHTSINFNLVLKG-NDTHNDF--VPETELKGNIF-
-QNS--SEVVNLKGK--SCDTDSGELICHEI-------EEPSSKKVK-SMDPCLGDCKDL
SEK--YHLDSID------DKPETTL---KS----ELNVD-NIEENACKT----------A
GDSQIEGV-KAMELVAEN----CES--SVS-EKVCLKTDTS-------------EL----
ATEKCKSSDEPGTETADKLG--AEVAAEAFCAGVGLCDNTTPINVK--------------
--------SQIENCEQIAGGELDDRSNEPDSASSKQMN-AKMEDYEEIVTE-----IGIV
TEAEDE------MTKSEETKTEQLNAELDSFA----PDTVEMSTEERKV----ESSKSET
STELHKAEE--TNVDDDQMVVEND--ILLQVNCT--PDKVEEPPQSLTSETTISELVTE-
N-NSSPEKLRELD--SLLVSANESPSG--M-QSRCVWSPLASPSTSILKRGLKRL-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCPLVKSH-SSNSSPIIKS---VKTSPTSQ
TKHNTTSAKGFLSPGSRNCKFKTSKKCLITEMVKESMPCPT-ESVYPALMSCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QMKSHGLEEIPVFDISEKTLNEVENKS--ADEERLA-----------------------S
DLIDPVALE--TPLSKNLVAQIRALALQLDSEDLHSYSGSQLFEMHEKLGTMANSIIKNL
QARWRSPAHENSS--------------

------------------------------------------------------------
----------------------------MTAPGPSPLAPLLETLEDSSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SLGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKNLPRLYKVLKSHISSQNSELCSAALQALGF
CLYNPKITSGLSEANIQELLSKLNNIV-KNSDKNVCTRALWVISKQTFPAEVVGKVV---
--------------------------SSIIDSLEIIFNKGEIHSAVVDFEALNVII----
------RLIEQAPVQMGEESVRWAKLVIPLVAHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLHLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISTDSCV-LPQGNSSRIATSPGLSPMTPV
HK-GASPYGVPGTPRMNTSSNLGGMATIPSIQLLGLEMLLHFLMGPEVLSFAKQHKLVLS
LEPLEHPLISSPSFFSKHAHTLITAVHDSFLAVGKDA--SDAVVSAVWKELISLVKSVTE
SGNRKERSGSEVLTLLLKSLESIVKSEVYPVSKTLVLMEITIQGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLEY-VADERFFLNLETLVGYVLSGPTSPLAF
SESVLNVINQNAKELENKEHLWRMWSIIVTPLTEMINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSIQKFPLATMKTLLRSWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
ESLSNLLYLDRIVHIITVMVDCIDFSPYNIKYQPNVKSPQRS-SDWSKKK-KEPLGKLAS
LFKLIVKVIYSFHTLSFKEVYSD----TLLAIGTSITNMLSNVFGHISLPSMIREIFATL
TRPLALFYEN-SK--LDEVPKVYSSLNNKLEKLLGEITTCLQYSYTGIYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTMLTYPEELKPVLRQAKQTLLLLLPGLESVEIM
E-ESSGPYSEVMENSQLNVKISGM--ERKSSGKRDSFLTQTKDKKE-NVK-------PSV
KLKLQSSSPKVKTE-MLLEEEKSEDFVFIPPEEKEAKERVLTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFSSHY--SQEESVET--PNSSEKPMEDSEMII-------KEKQMQHDSV
--IPQDTKENCGMNEHLEKASVS---------------NNGCSSVEETNPEVLMTSSNDV
RKITLTSSK-KASAECIPNAESSFVVN---SSVSNS--------SISGTP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLNSISSVVT----VKNNQENMTKTDTTLKTKKREVTRS-
-------------KSDSEKVVNGVKRSS-----RRSSKAE-------QSGNKKSKPLMK-
------------SEEEKNTLESTEDMI-ALEN-NPPNLLNQTECVQNN-QDHLS-ESTVE
YEDTKPKS-TIENDVVLENNSVEEKNGEVNLESKENTPPVIIPA-DQMINEENQVQ-ITS
NQKTLRRSSRRRSEIIESTTDSQDKENSHQKKERRKEEEKS-LQKSPLHVKDDVLPRQKL
TSEHA--VQENLVEKGNNLHEKTLGETS----------ANAEIDQNKRKPDLENISSEAD
G-AQDIADKSSEKPLRGRTRYQTRRASQGLLFSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNDSVD-MEEQEEKMV-QECIKVENQTPES---------KAISE
V--DM--KSQICETG-ESTVIVPQES--KISSDLLQVSDDVP-NTH----EGKSKTSKCT
ENS-----FTWPPVPESNLRTRNANKRLHK----GDS---DSV--GECSKVGSSSIALLS
EKSVQIVECQHKRS-RRVRRSKGCDCCREKSQPQE--NSFIGLRNIENDDEKNSET-KAD
VQTLGTVSKT-CDANLHSEVKILD-EHPSVNFDLGLKEENDTINDLVIVPATELKENTI-
-EKSVP-EIVNFKEG--TCDMDSGVATCLEN-------EEPSN-ILK-VVGPCACDSMDI
SQK-CSPLDTKK------RKQEFSP---E-----EVNIV-NVEGNACRA----------T
VGSNLEEV-EAMELDIKS----DKSETSLE-KDKSEANLVE--KKSAKIDISEEMVAEGN
TKSGIPEADKVEEVNAEELN-AEAAAAQEYNSGTGLSDNTTPINVN--------------
--------PQTEISEQKANGKLGGGSNESDLGSLEEIN-SEIENYEKTVTEQVNSETDSV
EETKDRDRTTK-TSKPEEAQTERLNVETDNFI----PDTLEMNTEEGKI----ECNKTET
NIELNKSEE--MKLDDNQVVVGND--TLQEVHHT--SETMEETLQSSSSETAISELVTE-
DNNASPQKLRELD--PLLLSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSSSSPIMKN---VKTSPTAQ
SKHNTTSAKGFLSPGSRSSKFKSSKKCLITEMAKESIPCPT-ESVYPALVNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSSLTASEIKTLPIRSPKVSNVKKAL-RVYHEQ
QVKSRGLEEIPIFDITEKAVNGIENKSLSTDEERLA-----------------------S
DLLDPVPFE--TPLSKNLVAQISALALQLDAEDLHSYSGSQLFEMHEKLGTMANSIIKNL
QSRWRSTAHENSI--------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDASASHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKALKTHISNQNSELSSAALQALGF
CLYNPKITSELSEANIKELLSKLNDIV-KSPDKNVRTRALWVISKQTFPTDVVGKMV---
--------------------------PSIIDSLETLFNKGEIHSAVVDFEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMVKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSSA-SPPGNSSRIATSSGLNPMTPV
HKGASSPFGPPITPRMNSSSSFGGMAAIPSIQLLGLEMLLHFLLGPEVLSFAKQNRLVLS
LEPLEYTLISSPSFFSKHANTLITAVRDSFVAVGKDA--SDAVVIAIWKELISLVKSVTE
SGNKKERPGSEVLTFLIKSLESVVKSEVFPVSRTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLTF-S-NLLECGIADERFFLNLETLVSCVLSGPTSPLAF
SDSVLNVINQNIKHLENTEHLWRVWSIIVTPLTELINQTNEVNQGDALEHNFSAVYGALI
LPINHIFSVQKFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELCSKIMSSLEG
EGLLNLFFLDRIVHIVTLMVDCIDFSPYDIKYQPKVKSPQRP-SDWNKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEEHSD----TLFAIGSSITNILSSVLGRISLPSMTRKIFATL
TQPLMLLYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGAFDSELLEQLSPL
LCITFLHKNKQIRKQSAQFWNATFAKVTVLIYPDELKSVLRQAKQKFLLLLPGLETVEMV
E-ESSEPYSDTTENSQLNMKISGM--ERKSSGKRDSLLALTKDKKE-NMK-------PPA
TPKVESSSLKVKSE-TLLEEEKSTDFVFIPPEGKDMKEKILTEHQKEVLKTKRCDIPTMY
N-NLDISQDTLF-SQY--SQEESMET--PTLSRKQKEDSKMMF-------EEEQMESDNV
--IPQDVTENCGMGEHLEKT--S---------------NNECGSVGKTSPEKLSAKKNDS
RKKALIPSK-KTSTECTSSTENSFV-S--SSSVANA--------TISGTS-PHP--RRQT
FITLEKFDGSE--NRPFSPSPLNDMSSTIT----VKNNQENMIKTDIPRKAKRREMTLS-
-------------KSDSEKASTATKRSG-----RRVGKAE-------QAGNKRYKPIMR-
------------SEQDKNTQESIEGIV-ILEN-NPPCLVNQTEHTSDN-QVHLS-QSAVE
YEDTKLKS-TVENAITLENNTVEEKNVEINLESKENTPPVVIPS-DQMVNEDSQSS-ITP
NQKTLRRSSRRRSEISESTADSQDKENNHQKRERRKEEEKP-FQKSPLHTKEDVLPKQKL
ICEQI--VQENLIEKGNNLHEKTLGETS----------ANAEIDQNKGKPDPENIKSEGD
G-VQDIAHKSSEKPVRGRTRYQTRRASQGFLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------SKSNDSVD-VEDQEEKMVKLDCIKAENQTHDC---------KASSE
V--DI--KSQVCEKKDESSTATLEDS---ISSDL-QVSDDGA-NIH----ERESKTSKCE
EYC-----FSSPPLPESNLRTRNANKRLHK----RDCVDNNSV--GESSKIQTSDMSLLH
EKTPQTLECQHKRS-RRVRRSKGCDCCGEKLQLQE--KSLVGLKNTENYDVKISETAKID
VQAPVTVSET-SKANVYSEVKFLD-EHHSVNFHLGLKEDNDTINNSLIESETEMKENTT-
-KETLPSKMINFKEE--ICDRDSSEVMPLKS-------QEPPNKKFI-AVGPCLGDSKDT
SQE--CSLETKE------EKSEITL---K-RDLSLQSVV-NVGKNACEI-----------
TESHLEEV-ETMQFSVQI----DKSEAIIS-EQQSAKTGIS-----------EPAA----
TEENSGRSGEFEADISKELN-ANEVATEKFNS-----DNTIPIAVN--------------
--------TQTEIPEQTPVGELDGASDISDEGSFEEMN-VEMENYEQTVIDEVNTEPDHL
SEREDEDVSIKTC-RSEETQRKRLNVEMDNFV----SDTLEMSTKEEKV----DCNKIET
DTELNTAKE--IKADDNQMVVGND--ILQ-EVCP--SERLEEPSKSLTSETGISELVIE-
D-NASPQKLRELD--PLLASANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEEE
ISSPINK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPVVKS---AKTSPTAQ
SKHNTTSIKGFLSPGSRSPKFKSSKKCLIAEMAKESMPCPM-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKRAL-RVYHEQ
QVKTRGLEEIPVFDISEKTINGIENKSLFPDEERLA-----------------------S
DLIDPVNLE--TPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSS--------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------MAVEYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLMEQTPTQMGEEAVRWAKLIIPMVIHSAHKVQLRGAAALEMGMPLLLQKQQEV
AVITEHLMTTKVISELQKLFSTKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGSPVVKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLVRLGPQLPANFEQVCVPLIQSTLSLDSSV-ILQGTPSRAAANQSLATATSA
QKSGSYPYGSPATPRINLNSSVSGIILIPSIQLLGIEMLLHFLMGPEVLSFSKQNKLVLS
LEPLQYPLISSPSFFCKHASTLINAVQEGFIAVGKEV--PDVMLNIIWKDMTGFVKAAIE
SGNKKERQGSEMLTVLLQALKNIVTSDALPAQKTLSLLEITIKELPSKVLGSPAYQVADM
DLLN--------GTPALFLIQLPF-RNNLLEWCVTEERFFLNLEVLVGCVLSGPTSPLAF
SESVFCIINQCTKQVENKEHLWRMWSIVVNPLTEWINQTSEVNQGDALEHNFNAIYSALL
LPISHIFPIEEFPQLTMKSLLRTWSELYRTFARCAALVATAEENLCCEELCAKI-SGLED
EA-LNLSVVDGLTHIVSVMVDCINFAPYGTKYQPKNRSPQTP-TDWSKKK-REPLGKLAS
LFKLLVKLINSFHMLSSQDTQSE----TLISVGTSIIVILHNIISHISSPSVIRTMFTTL
SKPLAMFYE--TK--LADTSRVYSSLSSKLEKLLGEIIVCLQSHSTGFYDSELLEQLSPL
LCTIFLHRSKQLRNQSALFWNATFAKATMLTYPQELKSVLNQAKKKILLSLPGFESVEVV
E-ESSDPFSDATENSQWDAKISGL--EVISGGKRDSLLAQASDLK----DKTTTPHVTTA
KLKLEFSSPKTKQSKILLEEEKSIDFVVIPPE---TKERILTEHQKEVLKTKRIDIPTMY
N-NLDASQDTALFSQYTQSQENSLDK--TSLIEEQKEDVEKKP-------QDERTKSDVH
-NSAHEITGNCKSSEPFENSVNIEDKSITHIPESSDSNYSSGLFCKSHLPRRIGR-----
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------

------------------------------------------------------------
----------------------------MTAAGRSPLEPLLETWEDPSASP

PF12231 // ENSGT00390000012204_0_Domain_1 (112, 504)

GEQTDAYLS
-----------LTSRMTGEEGKEVITEIEKNLPRLYRVLKAHISSQNSELSSAALQALGF
CLYNPKITSGLSGANIQELLLKLSSII-KSSDKNVCTRALWVISKQTFPTEVVNKMV---
--------------------------SSIIDSLEVVLNKGGTHSAVVDFEALNVII----
------RLIEQAPIQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEHLMTTKLISELQKLFVSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPGNFEQVCVPLIQSTISVDNST-SPQGSSSRGSASQGLSPVTS-
VHKGASIYGVPVTPRMNSSSNIGGMATIPSIQLLGLEMLLHFLLGPEVMSFAKQHKLVLS
LEPLEYPLIGSPSFFSKHANTLITAVRDSFVAVGKDA--SDAVVSAIWNELINLVKSVTE
SGNKKERPGSEALTLLLKSLENIVKSEVFPVSKALVLMEITIKGLPPKVLGSPAYQVANM
DILN--------GTPALFLIHLIF-NNNLLECGVADERFFLNLQTLVGCVLSGPTSPLAF
SESVLNVINQNAKQLENKEHLWRMWSIIVTPLTDLINQTNEVNQGDALEHNFSAIYCALT
LPINNIFSTQTFPMTATKMLLKTWSELYRSFARCAALVATAEENLCCEELCSKIMSSLED
EALSDLLFLDRISHIITVMVDCIDFSPYNIKYQPQIKLPQRS-SDWAKKK-KEPLGKLAS
LFKLLVRMIHSFQALSYKEVHTD----TLLAIGTSITSILSNVFGHISLPSMIREIFATL
TRPLALLYEN-SK--SEEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCMIFLHKNKQIRKQSALFWNATFAKVTVLVYPEELKPVLRQAKQNFLLLLPGLENVEMM
E-ESSGPYSDATENSQLNIKISGM--ERKSSARRDSFLAQTKDKKE-NMK-------PSA
KLKVESSSPKIKSD-KLLEEEKSVDFVFIPPEGKDSKQRILTEHQKEVLKAKRYDIPALY
N-NLDVSQDTLLSAQF--SQEESMES--LLLTEKPKEDSKMM--------IKEQGESDIF
--IPQDAMESCGMDEHLEKPSLS---------------NEYD-SVAKTNPEIPSIN-KDT
KKNTLISSM-KMSPECTSSAESSLVVS--SSSVSNA--------TVSGTP-PQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSPVT----VRNNQENTTKTDTP-KIRKREVALS-
-------------KSDSEKPVNGIKRSG-----RRSSKSE-------QSGNKRSKPLLK-
------------SEQEEHAQSM-------EEN-NPLDLLNQTECMSHI-QDYLS-EAAIV
HEDTEPKS-TVEDV--LENKTTEERNIGINVESKENTPPASTPT-DQVENEDSQAV-VAT
NPVTLRRSSRRRSELVESSTDSQDKENSQQRKERRKEDEKT-VQKSSSHVKDDKLPKQKL
TADQT--IQESLTEKGNELHEKTSGEPS----------ANVEIDQNKRKPDLENVRSEG-
DGAQDIVDKSSEKPLRGRTRYLTRRASQGLLSSIENSESDSSEAKEEVSKKKRTGKWK--
--------------NKSNDSVD-VEEQEGKTVEDECIKTDNQTDDC---------KAFSE
VHVDT--GAQNCEKSES-NIVTPQDS--TGSSDLMQISV-PP-AIY----EEKSKPSKCA
DYS-----FASPPVPESSLRTRNASKRLHK----RDSNN--S------------------
--VRESLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSFIGLKNTENYALKSVETKKTD
VQAPGTVSETYEAN-------QYS-EQPDVNFGLGLKEDNGTVDN-LITSETELKEDTQ-
-NSLMSEEIVNMKEK--TC--DGSSEAVSES-------QEPCSEKDK-DVDPALSDSKGM
SQE-CLSLDTKA------ENPEA----TLKRELNTDDE-----VNTCRV----------V
TGSSPEEV-EAMVLDAAN----DTSEAVFE-KE-SSQTDIP-----------EEMA----
TEESDKK-DEPEAG-TAGVS-TEETVTEGFNSSAQV------------------------
-----------------------------------------------------NTEIDSA
R-VEDTDTTAN-TSKGKQTQTEGLNVEADSFV----PGTLEMNTD----EVKTDSCKTET
N----MVLE--AKLADNQIAVEND--ILQETRLT--LEKVEEVPQSLTSEMAA-ELVAES
SD-ASPEKLRELD--PLLGSANESPSG--MQ-ARCIWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNNSPIIKS---VKTSPTAP
SKHNTTSIKGFLSPGSRSSKFKSSKKCLIAEMAKESMLSPT-ESVYPALVNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RVYHEQ
QMKSRGLEEIPVFDISDKAVNGIESKPLNTDEDRLV-----------------------S
DLMDPVTLDT--PLSRNLMTQISALALQLDSEDLYNYSGSQLFEMHEKLGTMANCIIKNL
QSRWRSPAHENSV--------------

------------------------------------------------------------
----------------------------MTAPGRSPLAPLLETLEDSSASPGEQTDAYLA
-----------LTSRMTGEEGKEVITEVEKKIPRLYKVLRTHISSPNLELSSAALQALGF
CLYNPKVTSGLSEANIQELLSKLNDIV-KSSDKNVRTRALWVLSKQTFPTELVGRVV---
--------------------------SNIIDSLEIVYNKGEIHSAIVDFEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLFSELQKLFMNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLAANFEQVCVPLIQSTISIDSST------SSRVATSPGMSPMTPV
TKGAS-TYGVPVTPRMNLISNLGGMAAIPSIQLLGLEMLLHFLLGPEVLNFAKQNKLVLS
LEPLEHPLISSPSFFSKHANILITAVHDSFVAVGKDA--SDAVLSAIWKELIGLVKSVTE
SGNKKERPGSEVLTVLLKSLEGIVKSEVFPVSKALILMEIAVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-S-NLLECGIADEKFFLNLETLVSCVLSGPTSPLAF
SDSVLNVINQNAKQLDNKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSVQKFPVATVKTLLKTWSELYRAFARCAALVATAEENLCCEELCFKIMSSMED
EDFINLLFLDRIVHVITVMVDCIDFSPYNAKYQPKVKSPQRP-SDWSKRK-KEPLGKLAS
LFKLIVRVIYSFHTLSFKEVHSD----TLLAIGVSVTNIISNVLGHISLPSVIRKIFATL
TRPLALFYEN-AK--LDEVPKVYGCLNNKLEKLLGEIIACLQFNYSGTYDSEFLEQLSPL
LRIIFLHKNKQIRKQSAQFWNATFAKVTTLNYPEELKPILRQAKQKFLLLLPGLENVEMM
E-ESSGPFSDATENSQLNLKISGM--ERRGSGKRDSLLSQTKDKKE-NMK-------PSG
KLKLDSSSSKVKND-MPLEEEKSTDFVFISPEENEAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTFLSSQY--SQEESMEI--STSTKKSKEDSKIMI-------KEEQIKSDIV
--SSQDVMENCGMDENLQNTPLS---------------NNESGSVDETNPKMLNI--NDA
KKRALISSK--PTTECTSKTDNSSVAS--SSSISST--------TMSGTP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLNDMSSPVT----VRNNQEYMSKSDSVSKTKKREMTLS-
-------------QCDSEKIVNGIKRSG-----RRCSKAE-------QSGNKRSKPLVR-
------------SNQEKNTQES-EGII-ALEN-NPACLLNQTECVSDN-QTHLS-EYTVE
YEDAKLKP-TVENVVLLENSTVEERSTETNLDSKENTPPAVIPA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEISESTTDSQDKENNQKRERRSKEEEKI-LQKSPFHVKVDVSPKQKL
TSEQT--VQENLIEKDN-LLEKTRGETS----------ANGEIDQNKRKSDVENIASEGD
G-SQDIADKSSDKPLRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKGNDSVD-IEDQEEKTVKQECMKVENQTYDC---------KASSE
VDSDI--KSQISEKGD--STIMLQDS--TVSSDLLHISDDVP-NTH----EGKSKTTKCE
EYY-----LTSPPVPESNLRTRNASKRLHK----RDSVDDNTM--GESSKTGTPDIPLLS
EKSLQTVECQHKRS-RRVRKSKGCDCCGEKSQSQE--KSVIGLKNTEN-DEKISGIKKID
VQTAVTLSET-S--HLYSEAKFVD-EHHSVNFHFDLKEENDTGNDLLVVPETDLKESVI-
-QESLPSQV-NFEES--D-NSVSIEVKNVES-------QEPANKKFR-SVGPCIGDPKNI
QQE--CSPFETE------EKLEGAP---Q-KESTIV----NDKNSYKVM-----------
VDSNPEEM-EAMKLDGEN----EKLEVNSS-EQENAKADLV-----------GKAA----
VAENSERSDESEPDRAEILN-TEKTAAEEFNVSIDLSENT-HIKLD--------------
--------AQNKTPEQS-VVDVGGGRDESNQGSSEEIN-ANLGSCDEAVISDVNAETDHV
KEMEDRDMIMKIS-KPEEAEIKRLNVETD-AV----PDALEMNAKEQKV----DSEKTET
NNELDKLEQ--TKSDDNQMVLEND--TLQDVHHT--SKKVEEPLHSLTSEAVVSELIRE-
DNNVSPQKLRELD--PLLMSANESPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
NSSPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-PLNNSPIAKS---VKISPTVQ
SKHNTTSTKGFLSPGSRSPKFKSSKKCLITEMVKESVPCPT-ESVYPALVNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKRAL-RVYHEQ
QVKSHGLEEIPVFDISEKTVNGIETKS--SDDERLA-----------------------S
DLADPVTLE--TPFSKNLMAQISALALQLDSEDLHNYSGNQLFEMHEKLGSMANSIIKNL
QSRWKSSAHENSI--------------

------------------------------------------------------------
----------------------------MTAPGRSPLEPLLETWEDPSVSPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 504)

EQTDAYLT
-----------LTSRMTGEEGKEVIAEIEKNLPRLYTVLKAHICSQSSELSSAALQALGF
CLYNPRITSGLSETNIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPTELVSKMV---
--------------------------SSIIDSLEVILSKGEIHSAVVDFEALNVIIS--H
WFLRC-RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSSA-SPQGSSSRGS-TPGLSPLTP-
GNKGA-SYGTP---RVNLGSNIGGMATIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLS
LEPLEHPLISSPSFFSKYAHTLITAVHDSFVAVGKDA--SDAVVSAIWKELISLVKSVTE
SGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIL-NNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAF
SDSVLTVINQNAKQLANKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSTPTFPTGTMKTLLKTWSELYRAFARCAAVVATAEENLCCEELSSKIMCSLED
EALSDLLFLDRISHVVVVMVDCIDFSPYNIKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVRIIDSFHTLSLKETYSD----TLLAIGNSIISMLSNIFGHISLSSMIREIFTTF
TRPLALLYEN-SK--LDEVPKVYTSLNNKLEKLLGEIVACLQFNYLGAYDSELLGQLSPL
LCIIFLHKNKQIRKQSAVLWNATFAKATALIYPEELKPILRQAKQKILLLLPGLENVEMS
E-SSGPYSDAKQENSQLNVKS-G---MRKSSGKRDL-LAHT-KKKR-KVR-------LSA
KLKKRSRSPDLKNG-EGSWERKVSDFVFHPSREKENKGVVVSEYWKGLCFFTRCDIPAF-
N-NLMRHQGTLFLLQL--VVSMKRES--LTLTEKPKEDAKII--------KEEQMESAIF
--IPQDAPENCTIDQHPEKASLP---------------NYGG-SVAETNPETLSTG-FDA
RKEMLISSK-MSAECSSS-SET-TVVS--SSSVSNA--------TFSGT--PQPTSRRQT
FITLEKFDGSE--TRPFSPSPLSNLSSTVT----VRNNQDNTTKTDMPQKARKREVTHS-
-------------KSDSEKLANGGKKSS-----RRWSKAE-------QSVNKKFKPSPT-
------------SEQEEQS----------FEN-NPPDLLSSAECVSEN-HDHPS-EATLE
HEDRDPRA-SVENA-SLEDLA-EGKNVGINKDPKESASPVVAAT-EQTVNEGSQAAAAAP
NPKALRRSSRRRSEAVESSGDSQEKESGQQKRERRKEEERT-ISKSPCHIKDDKLPKQKL
TAEPP--IQENLTEKENSLQERTLGEPS----------ANAEIDQNRRKPDLETVSSEGG
GGTLDNVDKSSEKPLRGRTRYQTRRASQGLISGVENSESDSSEAKEEVSRKKRSGKWK--
--------------NKSSDSVD-IEEQEEKMVEDEVMKTASQTHDG---------QAVPD
-DINA--VAQICEKNIN-NRVILQDS--SGSTDSLQVSL-----TG----EDKSKTSKCL
DSS-----LVSLPVPESNLRTRNASKR-LY----KRDTD--S-------NVGASDMSMSP
EKCTQVVECQHKRS-RRVRRSKSCDCCGEKSQSQE--KSFTGLKNTESSAMKSLETKKTD
LQMPETAPETQEA-NEHVETKSVG-KQPVVNFHLGLEEIS-ATGD-LIKSEPKLEEDSK-
-NSPP-SEPVNMKEK--TYGTDA-SEAVSEI-------QEPCGEEYNAPEDPCLSDCKDI
SQK-YPLDN-------------------K--ELDISNV-----GKACKV----------M
DGSSPEGV-ESIESSVRK----DTFGAAVS-EKSTQMDVS------------VDVA----
TEEDNKK-DECEAV-TTEVN-AEGVATEDFNSSMGLSDTTTPVSK-D-------------
--------VQA--EHPASGELEAGS-NESDSGSCEEMN-KEMESYKAQ----MNTEIDNA
R-VKDMDMIAS-TSKSEEALIGRLDVNTEGFV----SDIEMS-SG-----EGTGKCKTET
NIELNKLDE--IKLGGNQTTVGNE--TLQEVCFT--SEKVEELPQPLIPEVTS-ELGAES
NNV-SPVK-LELD--PSFGSASESPSG--VQ-ARCVWSPLASPSTSILKRALKRS-QEDE
I-SPINK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPVIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSSKFKSSKKCLITEMAQESMLSPT-ESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPIFDISEKAVNGVESKTLSTDEERFA-----------------------S
DLIDPVTLDT--PLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSTAHENS---------------

------------------------------------------------------------
----------------------------MTARDCSPLTPLLETLEDPATSVGEQVDAYLT
-----------LASRLTGEEGKEFIVEIKKQLPRLYKAFKTHISSQNSELNSATLQAMGF
CLYNPQITSGLSEREMEELLSQLTDIATKSTDKNTRTRALWVMSKQTIPSEIVGKAV---
--------------------------PSIITMLEVVFNKVDVHSMVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPIQMEEEAVRWAKLIIPLVVHSAQKVHLRGATALEMGMPLLLKKQQEV
AAVTEQLMTTKLIPELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPVIKKIAFIAWKSLIDNFALNPGKLKDILCSTKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPHLPTNFEQVCVPLIQSTISIDCHA-VSQGTPSRGAANTSLTPVTPN
QKAGSFPFGTPVTPRMNLSLNTSGMAAIPSIQLLGIEMLLHFLLGPDVLEFAKKNKLALS
LEPLQHPLISSPSFFCKHANILIAAVQDSFIAVGKDA--SDAVIYAIWKDIICFVKSVIE
SGNKKERQGSEVLTLLLQSLKSIVTANAFPVSKTLVLIEITIKGLPQKVLGSPAYQVANM
DLLNASILNMIIGTPALFLIQLIF-SSNLLECGVADERFFQNLETLVGCVLTGPTSPLAF
SDSVLNVINQNAKHLDNKELLWRMWSILVNPLTELINQTNEVNQGDALEHNFSAVYNALM
LPITHIFPSQEFPLPTMKSLLRTWSELYRTFARCAALVATAEENLCCDELCLKMMSGLDD
NTFGNLSFLDRIAHVTIVMVECINFSPYSTKHQPQIKLPQTP-TDWSKKK-KEPLGKLAS
LFKLILKMLGAFHNVNFKDLHSE----TLLSVGSSIISIISNILGHVSLPSVIQTIFATL
TKPLALLYEN-SK--LSDVPKVYNSLNNKLEKLLGEILRCLQVRYSGTYNSELLQQLSPL
LCIIFLHKNKQIRKQSVQFWNDTFAKEAVLEYPEELKTVLKQAKQKSLLLLPGLEV-EPI
E-ESGGLYSEGTENSQLDAKISGI--EIQSLGKQDSLSLRARNLKGKDLKSP-----SKV
RLENEFLSPKLK-KNDILEDCSSVDFVFIPPNEKETKERILTEHQKEVLRTKRSDIPTLY
N-NLDISQDSFSYH----TQEETMEN--PSLTEEPKEESKVIT-------KEESNDNT--
----KNNTENIIVDSSIEK-----------HPEKPSLPKHKVQSCHENNNSVLN-----I
KKHIEKNNSKIVSKEPSGENTCISDNT---LNTSS----------GSVSS--GPISRRQS
FITLEKFDTSE--NRPFSPSILNTVSGAVS----VSENQGNMDVASTSVKIKTKEINISK
PDK--------------EKMVGGTKKMV-----RRPYKTE-------HTGSKRPKLLR--
------------SEQEKNVQESGGSCRIPVEN-KLADLLDHTECISDTQDI-LPQAKVLE
CDETKCKH-PVENLGKVE-NINEKNDVGNNLESKENTPPEIIIPTEQIPNDDSH-IQVSS
NQKTLRRSSRRRSDTEG-TPDRQDKENGQQKKERRKEEEKC-VQKKFSQIKDDVSQKQKP
ISEKNAGEQEHLSKKANNMLEKTS--------------EQTNIEINKLKPEFE-IKSNVD
DFQDCSSDKSLQKPLRGRTRYQTRRASLGLLSSIENSESDSSETKEEISNKKRSGKWK--
--------------NKGSS-LE-NESLKGKIESKDCVD-----SETKIPEGKNEGETNSE
LDMEITLSSQIFDMKDEHNSSVIND--SIVSTDPSEVS-----SDTENTNEDKSKTNTLI
EDS-----DTNYSEPELILRTRNVNKKLHK----EDSMDNIAISPGGDVSDISDTSLLSE
NHPLQATECLHKRS-RRVRRSKSCDCCGEKSKLRE--KFFTSLKNTDNCDVKMNEPQKLD
LQ-SECTLETSYVSTDIEVKPLKE-S-FIVVEPLIHSKETETVTVSVTAPENELKENSNL
G-DCSPLEKIKFQNK--TCVIINNKTDFLG--------QEPSDKGDK-INDPSLS--INN
SQDSFEQ---KPFLEVNQ---GPAI----------I----SLKEEVCQSV----------
ELRNADDGNNTFDVKTKSDPETDISETEI--KCEIVTAEIDKIKSSADVDVSEVG-----
MQ-VD--ASGENDMAERETT-EPKTEADNTHTKI--------------------------
------------LADTK-----------AEMGSAQAKTLEASD------------ETDML
---------------------ESF---EEINTIKVK--A-ESETSEK--VKADTNYTEET
K--------------VDQDVV---DEINVKIQNT--SEKVEEPTK-TL--ANVSELVTV-
ENNVSPQKLRGTD----TQTENESPSG--V-HTRCIWSPLASPSTSILKRGIKRQ-QEDE
ASSPLNK--VRRVSFADPIYQEGLADDIDRRSPVVRSH-SSHSANNSSIAKSLKSSPTAQ
SKLNTTPTKGFLSPGSRSPKFKSSKKCLIAEMTKESPQCSN-ESIYPALVSCGAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTATEIKTLPIRSPKVSNVKKAL-RVYHEQ
QMKSRGLEEITLFEVSEKSLNGMENKPVTPDEETFV-----------------------S
DLIEPIA--SDCQQARNLVAQISALALQLNSEDLHNYSGSQLFEMQEKLGSMTNCIMKNL
QSRWRSPPHESSV--------------

------------------------------------------------------------
-------------------------------AAGSSLGPLLHTLQDPAAPPGELTDAHLT
-----------VVSRLSGEGAKAFTADFRKHFPQLCKVFKAHISSPNLELSNAALQALGF
CTFNSNNTAELSGSEMQDLLAAVNSVAVKSSDKNTRTRALWVISKQAFPPEVVKKEV---
--------------------------SNILSTLETILTKGEVQSVVVEYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLMEQVPAQMGEEAVRWAKLIIPLVVHSAHKVQLRGATALEMGMPLLLQKQQEV
AAVTEHLMTTKLISELQKLFSSKNETFVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGSPVVKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPHLPSNFEQVCVPLIQSTLSVDPAA-AFPGTPSR-PNNPSL--GSAP
SASGPFLFVSPGTPRMGLNSSTAGVLLFPSIQLLGMEMLLHFLMGPQVVDFAKQNKLVLS
LEPLQYPLISSPSFFCKHASTLINAVQDGFIAIGKEV--PDCLLNVIWKDINGYVKTAIE
AGNKKEKQGSEILTMLLQALKNTVRSNSRPVQKILSLIDITVKELPPKVLGSPAYQVADM
DLLN--------GTPALFLIQLPF-HNNLLECCVTDERFFGILESLVGAALSGPTSALAF
SESVLGVIDQSAEQVGNKEHLWRMWSIVVHPLTEWINQNNEVNQGDALEHNFSAVYSALL
LPVSHIFPTQGFPQPTLKSLLRSWSDLYRAFARCAALVATAEENLCCEELCAKIISGLEG
ETPVVFPMLEGLTHLVSVMVDCINFAPYGTKFQPKNRSPQTP-TDWAKKK-KEPLGKLSS
LFKLLLLLLNSFHELGSSELQAE----PL---GLSLLAALHALVSRISLPSLLGTTLATF
SQPLAVFYEK-TK--LLEVPKVYSNLNNKLEKLLAEILQCLQCHCPGSCDSELLQQLSPV
LCVAFQHRSKQIRQQSAQLWNCTFAKASSLTYPEQLKSVLSQAKKKIPLLLPGFESIELS
E-ECSGPFSDLMENSQLDTKISGM--EVKVGQKRDSILAQTSEPKSDGKDKSSNVQATPA
KLKLEFSSPKTT-SETLLEEEKSVDFVFIPPE---TKPRILTEHQKEVLRSKRADIPAMY
N-NLDVSQDTTSFSQYSQSQEDSL------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------

------------------------------------------------------------
----------------------------MTAPAQSPLQPLLETLEDASVSHGERTDAYLS
-----------LT-------------------------------S

PF12231 // ENSGT00390000012204_0_Domain_1 (166, 504)

ENSELSSAALQALGF
CLYNPKIASGLSEANTQELLLKLNSII-KSSDKNICTRALWVISKQTFPTEVVGKMV---
--------------------------SSIIDSLEEVFNKGEIHSAVVDFEALNVIIS--H
WFFYY-RLIEQAPIPMAEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLIPELQKLFINKNETYVLKLWPLFIKLLGKTLHRSGSFINSLLQLEELG
FRSGVPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPSNFEQVCVPLIQNTISLDSSA-LPQGSSSRVCASPGLSPMNS-
VHKGASPYGVGVTPRMNLSSTPGGMATVPSIQLLGLEMLLHFFLGPEVFSFAKQHKLILS
LEPLEHALISSPSFFSKHAHTLITAVHDSFVAVGKDA--SDAVVIAIWKELISLVKSVTE
SGNK-ERPGSDVLTLLLKSLENIVKSEVFPVSKTLILMEITIKELPRKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGLQDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQIENKEHLWRMWSSIVTPLTGWINQTNEVNQGDALEHNFSAIYGALI
LPVNHIFSVQRFPMAAMKTLLKTWSELYRAFARCAALVATAEENLCCEELSSKIMLCSED
EALSNLLFLDRIAHVITVMVECIDFSPCDIKYQPQIKSPQRS-SDWSKKK-KEPLGKLAS
LFKLIVRVIHSFHTLSFKENHSD----ALLAVGNSIINMLSNIFGHISLSSMIRKVVATF
SRPLALLYEN-PK--PNEIPKVYSCLNNKLEKLLGEMIACLQFSYTGAYDSELLEELSPL
LCITFLHKNKQIRKQSAVFWNATFAKVIALVYPEELKPVLRQAKENVLLLLPGLEDVEMM
E-ESSGPYSNTTENSQLDVKISGM--ERKSSGKRDSFLVQKKDKKE-NVK-------TPA
KLKLD-STPKVKSD-KLLEEENSTDFVFIPTEEKVAKERILTEHQKEVLKTKRHDIPALY
N-NLDVSQDTLFSAQF--SQDESMES--SSLTETPRDVSKTVI-------KDQT------
---ESDVVGSCGVDGHFQKGSLP---------------DECS-SAVETSPGIPNS-CNSA
KKNTLMSSQ-KMSAECASSSESSLVTT--NSSVSNA--------TISGTP-PQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNDMSSTIT----VRTNQENTTKTDTPPKTRKREVTHS-
-------------KSGSEKLVNGIKRSS-----RRCSRTE-------QSGNKKFKLSVQ-
------------SEQEAHTQESVEK------N-NSPDLPSQTEGVPDS-QDHLS---TEE
YEDTKPKP-AIENA-VMENKTTEEKNIVTNLDSKENTPPVAIPT-DQTVNEDSQVS-IVP
NPKTLRRSSRRRSELVESSTDSQDKENSQQKKERRKEEKPA-QKG-PMHVNDDKLPKQIL
ISGQT--IQENLTEKGNNLHEKTLGETC----------VSAEIDQSRRKPDLENIGSEG-
DSGQDIIDKLSEKPLRSRTRYQTRRASQGLLSSIENSESDSSEAKEEMSRKKRSGKWK--
--------------NKSSDSVE-IEEQEEKVVEE-CVKTESQAQDC---------TAVPE
VDVDIS--AQTSEKHES-ISEPLQDS--AVSSASLQVTD-VP-NTF----EEKSKASKSV
ESS-----FTSPPVPESNLRTRNACKRLQK----GDSDS--SA--RE----SSKTGTPGT
PKRIQTLECQHKRS-RRVRKSKGCDCCGQKSQPQE--KSFTGLKTTENSDIKSSETQTDE
-LTPGTVSRTCEA-NQYSEAKFAG-EQPSVNFHLDLKEENNANGL-LIIPESESKENTP-
-KPLP-LEIVAVQDK--TCATHS-SEGSPEG-------HKPSSEEHEAVN-QCLGDS---
-KD-ISQEH--------STYTKENLEAILKREQNIIVFA-E-------------------
--PKPEEV-EAMELNIDE----SGF----S-EKEGAQVDIS-----------EEVA----
TEE--KKSDEPQLGTVEEIT-EVTAANSC----VGLPGNSTPVKI---------------
----NAH---TEISEHIPSGVHQGGSSESEVGSSKETS-AEMEV----------------
----DKETV-------------IGQV----------NSKAVMSAE----DGNAGAYKTKP
NIEL---ES--EQFNDNKILVRND--ILREVDHT--SETVEELPDTLSSERTE-LM--S-
ENNASPEKSRELD--PLLVSANESP-SG-I-QARCVWSPLASPSISILKRGLKRS-QEDE
IVSPLNK--VRRVSFADPIYQAGLADDIDRRCSLVRSH-SSNSSPIIKS---VKTSPTVQ
SKHNATASKGFLSPGSRSSKFKSSKKCLITEMTKECLLSPS-ESVYPALVNCAAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RLYHEQ
QVKSRGLEEIPVFDISEKAVNGVENKPLLTDEERLT-----------------------S
DLMDPVPLAT--PLPKNLVAQVSALALQLDSEDLYSYSGSQLFEIHEKLGYMANSIIKNL
QSRWRSPTCED----------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSASHGGQTDAYLS
-----------LTSRMTGEEGKEVIIEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEILFNKGETHSAVVDFEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPTQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLS
LEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKSLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLLVDRIIHIITVMVDCIDFSPYTIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLVHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTLLVYPEELKPVLTQAKQKFLLLLPGLETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NTK-------PAA
KLKLESSSLKVKNE-ILLEEEKSTDFVFIPPQGKDAKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQY--SQEESMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDRGMDEHLEKASLS---------------NNKCGSLDNTSPEMS-NSNNDD
RKKALISSK-KTSTECASSTENSFVVS--SSSVSNA--------TVSGTP-SCPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKTKQREGPFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKKSKPLIR-
------------SEQEKNTEESIEGMV-VLEN-NPSGLLNQTECVSDN-QVHLS-ESIME
HDNTKLKAATMENAVLLETNTVEEKNVEINLESKENTPPVVIST-DQLVNEDSLVL-ITP
NQKTLRRSSRRRSEIVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--VPENLIEKGNNLLEKTLGETS----------ANAETEQNKKKPDPDNIKSEGD
G-SQD-IDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDD---------KASSQ
EDINI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NPC----EEKNETSKYA
EHS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSF--GESTKIGISDVSSLS
EK-LQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGLKNTENNDVEVSETKKAD
AQAPVSTSET-SQANPYSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFGEE--TCDMDSSEAMSLES-------QESRNENFK-TVGPCLGDSKNV
SQE---SLETK-------EKPEETP---K-MEMSLEN-V-TVEGNACKV-----------
TKSNLEKV-ETMELDVGN-------EASFR-EQETTKTGIS-----------EEAA----
IEN--KRNDDSEADTA-KLN-AKEVATEEFNSGISLSDNTTPVKLN--------------
--------AQTEISEQTAAGEL---NDVSDPHSSEETN-TKMKNDEEMMIGEVKAETGHD
GETENEGINTKTP-KPDEAETKMLTAEVENFV----CDTVEMSTEEGLT----DANKIET
NTECSKS-E--EKLDSNHMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELITE-
DNNASPQKLRELD--PSLMSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEEE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTTQ
SKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMAKESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DTIDPVPLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANCIIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAADQSPLAPLLETLEDPSASL

PF12231 // ENSGT00390000012204_0_Domain_0 (112, 235)

GEQTDAYLT
-----------LTSRMTGEDGKEIITEIEKKLPQLFKVLKAHIASQNSELSSAALQALGF
CLYNPKIASGLSEINIQELLSKLNDIV-KSSDKNVRTRALWVISKQTFPTEVVGKVVSIV
FVYVVLTTCQLKNTGLLGLFVSVFQVSSIIDSLEIVFNRGEMHSAVVDYEALNVII----
------RLIEQAPVQMGEESIRWAKLVIPLLVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGSSSRVA-TPGLNPVTPV
HK-GASPYGSPITPRMNLNSNF-GMATIPSIQLLGLEMLLHFLLGPEVVSFAKQNKLILS
LEPLEHPLISSSSFFSKHSNTLITAVHDSFVAVGKDA--SDVVINAIWKELISLVKSVIE
SGNKKERPGSEVLTLLLKSLESIVNSEVFPVLKTLVLMEITIKGLPQKVLGSPAYQ----
------------GTPALFLIQLIF-NNNLLECGVEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLDNKEHLWRMWNIIVTPLTELINQTNEVNQGDALEHNFSAIYGALI
LPINHIFPAQKIPTVTMKTLLKTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGLSNLLFLDRITHIITVMVDCIDFSPYNIKYQPKTKSPQRP-TDWSKKK-KEPLGKLAS
LIKLIVRVICSFHTLSLKEVHSD----TLLTIGNSITSILSSVLGRISLPSMIRNIFATL
TRPLALFYEN-TK--FDEVPKVYSCMNNKLEKLLGEIIACLHVSYTGTYDSELLEQISPL
LCIIFSHKNKQIRKQSAQFWNATFAKVTMLIYPEELKPILKQAKQKSLLLLPGLENVEIM
E-ESSGPYSDTTENSQLNMKISGM--ERKSSGKRDSFLAQTKDTKD-SMK-------PPA
KLKLESSTPKAKCE-MPLEEEKSTDFVFIPPEVKETKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLFS-QY--SQEESMEI--STLTEKSKEDSKMIF-------KEEQKENDIV
--IPQHVMENCGMDEHLEKASLL---------------NNECGSIEETSPEIPSS-NNDA
RK-KALIAS-NKPTECASTTENPFGVP--SSSVSNA--------TISGAP-LQPTSRRQS
FITLEKFDGSE--NRPFSPSPLNNMSSTVI----VKNNQEGMAKTDNPSKAKQREVALS-
-------------KPDSEK-THGTKRSS-----RRSSKPE-------PIGSKKSKPLMR-
------------SEQEKSTQESVDGTI-ALEN-NPPGLLNQTECVLDN-QVHLS-ESAVE
CEDTMLKS-TMENTVLLENNTVEERTLEINLESKENTPPAII-T-DQTVSEDSHIQ-VTP
NQKTLRRSLRRRSEIAEPTTDSQDKENNHQKRERRKEEEKT-PQKSPLHVKDDVLPKQKL
ISEQS--VQENLVDKGNNLHEKAFGETS----------ANAETDENRRKPYLENTKSEGD
G-VQDIVDKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSKKKRSGKWK--
--------------NKNSDSVD-IEDQEEKMVQQECIKVENQAHDY---------KGNPE
VDKDI--KSQICEKREESNTVTLQDS--AVSPDLLQVYDDVL-NTS----EGKSKSNKDA
EHS-----FSNPSVPESNLRTRNANKRLHK----RDSIEN-SM--GESSKIGTSDISLLS
EKTLQTVECQHKRS-RRVRRSKGCDCCGEKSQAQE--KSFTELKDTENYDVKVNETEKTD
VETPVSISET-SKADLYSEVKLLD-EHHSVNFHLDLKEENDTTTDSLIISETELKENTT-
-QSFLPSEMIKFKET---SHRDSEEAISVES-------QEPCNKKCK-TVDPNLDVSKDI
SLE-CFSLETKE------GKSEATP---KEKLS-TENIV-IVESN---------------
AESNPEVV-DAMELNIEN----DQSEAGFS-EQESVKT----------------GN----
AEKEVTEENSERMDTPESVK-VDEAVTEEFNSAADYSDNPTPVKGN--------------
--------AQVEISEQMTVGELGRGSDESDPGSSEEMN-SEMKNCEKTVVGEVTTESDHV
TETEEEDLTTT-ASLPVEAETKGLDTEVNSFV----PDTIEMITEEGKV----DPNKTET
NIEPNKLEE--TQLDDNQMVVESN-ETLPEVHHT--SEKVEEIPQPLTSETGVSGLISE-
DSNTSPQKLKDID--PLLMSANESPSG--M-HTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIVRCH-SSNSSLMVKS---VRTSPTVQ
SKHNTTSAKGFLSPGSRSSKFKSSKKCLIAEMAKESVPCPT-ESVYPALVNCVAPVEIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RMYHEQ
QVKSRGLEEIPVFDISEKTINGMENKSISPDEERLA-----------------------S
DLIDPVALE--APLSKNLVAQISALALQLDSEDLYNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSF--------------

------------------------------------------------------------
----------------------------MTARGQGPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_1 (110, 504)

SHGEQTDAYLT
-----------LTSRMTGEEGKEVIIEIEKKLLRLYKVLKTHISSQNSELSSAALQALGF
CLYNPKITSELSEANIQELLSKLNDTV-KSPDKNVRTRALWVISKQTFPPEVVGKMV---
--------------------------PSIIDSLEILFNKGEMHSAVVDFEALNVII----
------RLIEQAPVHMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLKKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-LPQGNSSRVAASAGLNPMTPI
HKGASSPYGTPVTPRLNLSSNLGGMAAIPSIQLLGLEMLLHFLLGPEVLSFAKHNKLVLS
LEPLEHPLISSPCFFSKHANILITAVHDSFVAVGKDA--SDAVVSAIWKELINLVKSVTE
SGNKKERPGSEILTLLIKSLESIVRSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLTF-T-NLLECGIADERFFLNLEALVSCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALI
LPINHIFSVQKFPVATMKTLIRTWSELYRAFARCAALVATAEENLCCEELCSKIMSSLEE
EGLSNLLFLDRIVHIVTVMFDCIDFSPYDIKYKPKVKSSQRPSSDWSKKK-NEPLGKLTS
LFKLTVRVIYSFHTLSFKEEHSD----TLFAIGNSITSILSNVVGHISLPSMIRKIFATL
TQPLALLYEN-SK--LDEVPKVYSCLNNKLEKLLGEIITCLQFIYTGTYDSELLEQLSPL
LCITFLHKNKQIRKQSAQFWNATFAKVTMLIYPDELKPVLRQAKQKFLLLLPGLETVEMM
E-ESSGPYSDATENSQLNVKISGM--ERKSSGKRDSFLAQTKDKKE-KMK-------PPA
KLKLESSSLKVKSE-ILLEEEKSTDFVFISPEGKDGKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-SQY--GQEESMEI--PAVTRKPKEDSKMMF-------KEEQMESDSV
--IPQDVTENCGMDEQLEKASFS---------------NKECGSVDETSSKIL-SSNTDA
RKKALIPSK-KTSTECASSAESSVVVS--SSSVSNA--------AISGTP-PQPTSRRQT
FITLEKFDGSE--NRPFSPSPLNDMSSTVT----VKSNQENMIKTGIPPKAKQREVTLS-
-------------KSDSEKTSNATKRSG-----RRLGKAE-------QIGNKRSKPLMK-
------------SEQEKSTQESIEGMV-TLEN-NPPGLLNQTECVSDN-QVHLS-ESAVE
YEDTKFKP-TIENAVLLETNTIEEKNVKINLESKENTPPAGIPS-DQTVNDDSQAQ-ITP
NQKTLRRSSRRRSEIAESTTDSQDKENNHQKRERRKEEEKP-LQKNPLHIKDDLLPKQKL
ISEQI--VQENLIEKGNSLHEKTSGETS----------ANAEIDQNKRKPDLENIKSEGD
G-AQDVADKSSEKPVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWK--
--------------SKSNDSVD-IEDQEEKMVKQECIKAENQTHDH---------KASSE
VDVDI--KSQVCEKKDESSTVILEDS---ASSDLLQISDDVA-NTC----EGESKTSKCA
EYF-----FTSPPVPESNLRTRNASKRLHK----RDSIDNYSV--GESSKIETSDISLPS
EKTLETLECHHKRS-RRVRRSKSCDCCGEKSQLQE--KSFIGLKNTENYDVKISETKKTD
VQTPVTISET-SKANLCSEVKFLD-EHHSVDFHLGIKEDNDTINDLLIVSETELKENTI-
-QETLPSEIVNFKEE--TCGMDSSEVKSLQS-------QEPPNKKFK-AAGPCLADSKDI
SQE--CSLETKE------EKPEATL---E-GELSRGYVV-NVEENACKV-----------
AESNLQKV-ETMELDVRN----DKSEASFS-EQESTKTDIS-----------EEAA----
TEENSSSGDESEADTAKKLY-AKEAATEEFNSGISLSDNTTPITVN--------------
--------AQTEMSEQTAVGGLDGGSDVSDSGSSEEMN-AEVEKCEETVIDEVNAETDHV
NKTEDEDMSIKTS-KPEDAETKGLNAEIDNIV----SDTLEVSTEEGKV----DCNKTET
NTELNVPEE--I--DDNQMVVGND--ILQ-EVHT--SKKVEEPPQSLTSETGISELIIE-
DNNASPQKLRELN--PSLVSANYSPSG--M-QTRCIWSPLASPSTSILKRGLKRP-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCPVVRSH-SSNSSPIVKS---VKTSPTAQ
SKHNTTSIKGFLSPGSRSPKFKSSKKCLITEMVKESMPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
DLIDPVNLE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSI--------------

------------------------------------------------------------
------------------------------------------NWRSPPLPPPRDR---VL
-----------CIIRM

PF12231 // ENSGT00390000012204_0_Domain_1 (137, 504)

TGQEGKEVITEIEKNLPRLYTVLKAHISSQNSELSSAALQALGF
CLYNPKITSGLSEANIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPTELVSKMV---
--------------------------SSIIDSLEVILSKGEVHSAVVDFEALNVII----
------RLIEQTPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFMNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPGNFEQVCVPLIQSTISVDSIA-SPQGSSSRGSTSPGLSPLTP-
GHKGAS---YPATPRMNQSSNIGGMASIPSIQLLGLEMMLHFLLGPEVLNFAKQHKLVLS
LEPLEHPLISSPSFFSKHANVLITAVHDSFVAVGRDA--SDAVVSAIWKELISLVKSVTE
SGNKKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVADEKFFLNLETLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLANKEHLWRMWSIIVTPLTDRIHQTNEVNQGDALEHNFSAIYGALT
LPINHVFSAQTFPMATMKTLLKTWSELYRAFACCAALVATAEENLCCEELCSKILCSVED
ETLLDLLFLDRISQIIIVMVDCIDFSPYNIKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVRVIHSFHTLTFKETYSD----TLLTIGNSVISMLSSIFGHISLPSMIREIFATF
TRPLALLYEN-AK--LDEVPKVYNSLNNKLEKLLGEIIACLQYNYPGAYDSELLGQLSPL
LCIVFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMM
D-ESSGPYSDATENSQLNVKISGM--ERKSSGKRDSFLTQTKDKKE-NMK-------LST
KLKVGSSSPKLKSGNKLLEEEKSTDFVFIPPQGKEGKARILTEHQKEVLKTKRCDIPALY
N-NLDVSQDTLFSAQF--SQEESMES--LTLTEKPKEDAKII--------KEEQMESAIF
--ISQDAMENCGVDEHPGKASLP---------------NDSG-SVAETNSETLSAG-IDA
TKNMLISSK-IMSAEYSSGTETSLVVS--NSSVSNA--------TVSGTP-SQPTSRRQT
FITLEKYDGSE--NRPFSPSPLNSMSSTVT----VRNNQENTAKTDMLPKARKREVTHS-
-------------KSDSEKLVNGGKKSG-----RRWSKVE-------QSTNKKSKPSLR-
------------SEQEEHA----------LEN-NPPDLLSQTECLSK--HDHPS-GATLE
HEDKNPKP-TVENA-SLEDSATEEKNVSINTESKENTPPVTAPA-DQIVNEESQSV-VAP
NPKILRRSSRRRPEMVESSNDSQDKDNGQPKKERRKEEEKT-VAKSPLHIKDDKLPKQKL
SAESS--LQENVTEKGNSLHEKTLEESS----------ANAEIDQNKRKPDHENINSEG-
GSTQDNVDKSSEKPLRGRTRYQTRRASQGLLSELS--EPDSSESKEEVSRKKRSGKWK--
--------------NKSSDSVD-IEEQEDKMVEEECIKTAHEIHDG---------QAVPE
AHVDA--VAQICEESA--NRVILQES--AGSSDSLQVTD-TP-VAG----EDTSKTSKCV
DNS-----FASPPVPESNLRTRNATKRLYK-----RDTD--S-------SLGESDISVPS
EKWAQAVECQHKRS-RRVRRSKSCDCCGEKSQSQE--KSFTGLKNTESFAIKSMETKTTQ
MQAPEATPATCEA-NEHAKTKLAD-EHPSMNFHVGLE-ENGAAGD-LVKSETGLAEDRK-
-KV-P-SEIGNTKEK--SHDTDS-SEIVSEI-------QEPSNEKFT-AEDPCLCDSKDI
SQI-SSLDN-------------------KVEKSDIGDV-----GKACKV----------I
TGSSSEGG-EAMELDGGN----DSLGAAFS-E-KSAHMDIP-----------VDVA----
AEEDNKK-DEFEAV-TAEVN-AEGAATEGFNSALSLCDHATPVSK-S-------------
--------VES--EHSARVDLEDGHGVQSDCGSCEEMN-TETE---------------SS
K-AADRGMIVS-TSVSEETPGGRRGVKTESFV----CDTLEMSSE-----EGTVCYKTET
NIEL-KLDE--TKLSDNQNVVDNN--VLQEVCLT--SEKVEELPQSLTSEVTS-ELVAES
S-NASPEKLRELD--PSLGSANESPSG--MQ-ARCVWSPLASPSTSILKRGLKRA-HEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPIIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSSKFKSSKKCLIAEMAKESMLSPTTESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPVFDISEKAVNGVESKPLSADEEKLA-----------------------S
DLIDPVTVDT--PLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNL
QSRWRSPVHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSASHGGQTDYFFF
PVNYLNLCSSC

PF12231 // ENSGT00390000012204_0_Domain_1 (132, 504)

FLSRMTGEEGKEVITEIEKKLPRLYKVLKTHISSQNSELSSAALQALGF
CLYNSKITSELSEANALELLSKLNDTI-KSSDKNVRTRALWVISKQTFPSEVVGKMV---
--------------------------SSIIDSLEVLFNKGETHSAVVDFEALNVII----
------RLIEQAPIQMGEEAVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGNSCHVATSPGLNPMTPV
HKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQNKLVLS
LEPLEYPLISSPSFFSKHANTVITAVHDSFVAVGKDA--PDVVVSAIWKELISLVKSVTE
SGNKKEKPGSEVLTLLLKFLESIVKSEVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NFLECGVSDERFFLSLESLVGCVLSGPTSPLAF
SDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEHNFSAIYGALT
LPVNHIFSEQRFPVTTMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLED
EGFSNLLFVDRIIHIITVMVDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-NEPLGKLTS
LFKLIVKVIYSFHTLSFKEAHSD----TLFTIGNSITSIISSVLGHISLPSMIRKIFATL
TRPLALFYEN-SK--LDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPL
LCIVFLHKNKQIRKQSAQFWNATFAKVTMLVYPEELKPVLTQAKQKFLLLLPGVETVEMM
E-ESSGPYSDGTENSQLNVKISGM--ERKSNGKRDSFLAQTKNKKE-NMK-------PAA
KLKLESSSLKVKSE-ILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMY
N-NLDVSQDTLF-TQD--SQEEPMEI--PTLTRKPKEDSKMMI-------TEEQMDSDIV
--IPQDVTEDCGMDEHLEKASLS---------------NNECGSLDKTSPEMS-NSNNDD
RKKALISSK-KTSIECASSTENSCVVS--SSSVSNT--------TVAGTP-PYPTSRRQT
FITLEKFDGSE--NRPFSPSPLNNISSTVT----VKNNQETMIKTDFLPKAKQREGTFS-
-------------KSDSEKIVNGTKRSS-----RRAGKAE-------QTGNKRSKPLMR-
------------SEPEKNTEESIEGIV-VLEN-NPPGLLNQTECVSDN-QVHLS-ESAVE
HDNTKLKATTMENAVLLETNTVEEKNVEINLESKENTPPVVISA-DQMVNEDSQVQ-ITP
NQKTLRRSSRRRSEVVESTTESQDKENNHQKKERRKEEEKP-LQKSPLHIKDDVLPKQKL
ISEQT--LQESLIEKGSNLHEKTLGETS----------ANAETEQNKKKADPENIKSEGD
G-TQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGSRKKRSGKWR--
--------------NKSNESVD-IQDQEEKVVKQECIKAENQSHDC---------KVSSE
EDGSI--KPQICEKQDESSTVICQDS--TVTSDLLQVPDDLP-NAC----EEKNETSKYA
EYS-----FTSLPVPESNLRTRNAIKRLHK----RDSFDNCSL--GESSKIGMSDISSLS
EKTFQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSLVGIKNTE-NDVEISETKKAD
VQAPVSTSET-SQANPCSEGQFLD-EHHSVNFHLGLKEDNDTINDSLIISETKSKENTM-
-QESLPSGIVNFREE--TCDMDSSEAMSLES-------QESPKENFK-TVGPCLGDSKNV
SRE---SLETKE------EKPEETP---K-MELSLEN-V-TVEGNACKV-----------
TESNPEKV-KTMELDVGN-------EASFY-EQERTKSGIS-----------EEAA----
MEN--KRNDDSKADTA-KLN-AKEVTTEEFNSDISLSDNTTPVKLS--------------
--------AQTEISEQTATGELDGGNDVSDPYSSEETN-TEMKNYEEMMIGEVKAETGHD
GETENEGITTKTS-KPDEAETKMLTAEMDNFL----CDTVEMSIEEGII----DANKTET
NTECSKS-E--EKLDNNQMVMESD--ILQEDHHT--SEKVEEPSQSLTSGTAISELIIG-
DNNASPQKQRELD--PSLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRS-QEDE
ISSPVNK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNSSPIGKS---VKTSPTAQ
SK--------------------------ISEMARESIPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLA-----------------------S
E----------TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLSSMANSVIKNL
QSRWRSPSHENSI--------------

------------------------------------------------------------
----------------------------MTAPGRSPLEPLLETWEDPSVPPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 504)

EQTDAYLT
-----------LTSRMTGEEGKEVIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGF
CLYNPRITSGLSEANIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPAELVSKMV---
--------------------------SSIIDSLEVILSKGEIHSAVVDFEALNVIIS--H
WFLHC-RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSIP-SPQGNSSRGSASPGLSPLTP-
GHKGASPYGSP---RGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLS
LEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDA--SDAVVSAIWKELISLVKSVTE
AGNRKEKSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAF
SDSVLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQTFPTGTMKALLKTWSELYRAFTRCASLVATAEENLCCEELSSKIMCSLED
EVLSDLLFLDRISHIIIVMVDCIDFSPYNKKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVKVIDTFHTLSLKETFSD----TLLAIGNSIISMLSNVFGHISLPSMIREIFATF
TRPLALLYEN-SK--LDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPL
LCVIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMM
D-ESSEPYSESTENSQLNVKISGM--ERKSSGKRDSILAHTKDKKK-KVK-------LSA
KLKLESSSPKIKSG-KLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALY
N-NLDASQDTLFSAQF--SQEESMES--LTLTEKPKEDAKII--------KEEQMESTIF
--IHQDAPENCGIDEHSENASLP---------------NCGG-SVAETNPETLITG-FDA
RKEVLISSK-ILSAESSSSTETSV-VS--SSSVSNA--------TFSGTP-PQPTSRRQT
FITLEKFDGSE--TRPFSPSPLNNISSTVT----VRNNQDNTTNTDMPPKARKREVTNS-
-------------KSDSENLANAGKKSS-----RRWSKAE-------QSVTKKSKPSLT-
------------SEQEEHS----------SEN-NSPDLLSPTEHVSEN-DDHPS-EATLE
HKDGDPKP-AVENA-SLEDLTTEEKNVGINMESKESTASVVART-EQIVNEDSQAAALAP
NPKTLRRSSRRRSEAVDSCSDSQERESGQQKKERRKEEEKI-ISKSPLRIKDDKLPTQKL
TDESP--IQENLTEKGNTLPERTSGEPS----------VNAEIDQNRRKPDLENVSSEGG
GGTLDNLDKSSEKPLRGRTRYQTRRASQGLISAVENSESDSSEAKEEVSRKKRSGKWK--
--------------NRSSDSVD-IEEQEEKKAEEEVMKTANQTLDG---------QAVPD
VDVNA--AAQVCEKSTNNNRVILQDS--AGPADSLQAPP-----KG----EEKSKINKCV
DSS-----FVSLPVPESNLRTRNASKRLLY----KQDND--S-------NVRVSDSSLSP
EKFTQ-VECQHKRS-RRVRRSKSCDCCGEKSQSQE--KSFIGLKNTESYAIKSVEKKKTD
LQVPETAPETREA-RDHAETKLAG-EEPLVNFHVGLKEENCTTGD-SVKSEAELQEA---
--SLP-PEIVTVKEK--TYDTDA-SEAVSEI-------QGPCSENHSPAEDPGLSECKDI
SQK-QLSEN-------------------G--ELDISDV-----GKACKV----------I
AGSSPEGV-ETMELNVRN----DAFVAADS-EKSTQMDVS------------VDVA----
TEEDNKK-DECEAV-TTEVN-VEGVATEDFNSGMDLSDTPIPVSK-D-------------
--------VET--EHAASGEIEGES-NESDSGSCEEMN-KEMGSHKAQ----MSTEIDSA
R-VKETDILAS-ASKSEEALIGRLDVNTQSFV----SDIEMS-SG-----ERTVNCKTET
SIELNKLDE--AKLSGNEATVGND--TLQEVCFT--SEKVEKLPQCLLVQVAS-ELGAES
NTT-SPEK-LELD--S-FGSVNESPSG--MQQARCVWSPLASPSTSILKRGLKRS-QEDE
I-SPVNK--IRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPIIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSSKFKSPKKCLITEMAQESMLSPT-ESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFA-----------------------S
DLIEPVTLDT--PLSKNLVAQISALALQLDSEDLYSYTGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTAPGRSPLEPLLETWEDPSVPPG

PF12231 // ENSGT00390000012204_0_Domain_1 (113, 504)

EQTDAYLT
-----------LTSRMTGEEGKEVIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGF
CLYNPRITSGLSEANIQELLLTLNGII-KSSDKNVCTRALWVISKQTFPAELVSKMV---
--------------------------SSIIDSLEVILSKGEIHSAVVDFEALNVIIS--H
WFLHC-RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSIP-SPQGNPSRGSASPGLSPLTP-
GHKGASPYGSP---RGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLS
LEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDA--SDAVVSAIWKELISLVKSVTE
AGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAF
SDSVLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALT
LPINHIFSAQTFPTGTMKALLKTWSELYRAFTRCAALVATAEENLCCEELSSKIMCSLED
EALSDLLFLDRISHIIIVMVDCIDFSPYNKKYQPKIKSPQRS-SDWSRKK-KEPLGKLAS
LFKLIVRVMDTFHTLSLKETFSD----TLLAIGNSIISMLSNVFGHISLPSMIREIFATF
TRPLALLYEN-SK--LDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPL
LCIIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMM
D-ESSELYSESTENSQLNVKISGM--ERKSSGKRDSILAHTKDKKK-KVK-------LSA
QLKLESSSPKIRSG-KLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALY
N-NLDASQDTLFSAQF--SQEESMES--LTLTEKPKEDAKII--------KEEQMESTIF
--IHQDAPENCGIDEHSENASLP---------------NCGG-SVAETNPETLITG-FDA
RKEVLISSK-IMSAESSSSTETSVSVS--STSVSNA--------TFSGTP-PQPTSRRQT
FITLEKFDGSE--TRPFSPSPLNNMSSTVT----VRNNQDNTTNTDMPPKARKREVTNS-
-------------KSDSDNLANAGKKSS-----RRWSKAE-------QSVTKKSKPSLT-
------------SEQEEHS----------SEN-NSPDLLSPTEHVSEN-DDHPS-EATLE
HKDGDPKP-A-----SLEDLTTEEKNVGINMESKESTASVVART-EQIVNEDSQAAALAT
NPKTLRRSSRRRSEAVDSCSDSQERESGQQKKERRKEEEKI-ISKSPLRIKDDKLPTQKL
TDESL--IQENLTEKGNSLPERTSGEPS----------VNAEIDQNRRKPDLENVSSEGG
GGTLDNLDKSSEKPLRGRTRYQTRRASQGLISGVENSESDSSEAKEEVSRKKRSGKWK--
--------------NRSSDSVD-IEEQEEKKAEEEVMKTANQTLDG---------QAVPD
VDINA--TAQVCEKSTNNKRVILQDS--AGPAESLQAPP-----KG----EEKSKMSKCV
DSS-----FVSLPVPESNLRTRNASKRLLY----KQDTD--S-------NVRVSDSSLSP
EKFTQ-VECQHKRS-RRVRRSKSCDCCGEKSQSQE--KSFIGLKNTESYAIKSAEKKKTD
IQVPETAPETREA-SDHAETKLAG-EEPLVNFHLGLKEENCTTGD-SVKSEAELEEA---
--SLP-SEIVTMKEK--TYDTDA-SEAVSEI-------QEPCSEKHSPAEDPCLSECKDI
SQK-QLSEN-------------------G--ELDISDV-----GKACKV----------I
AGSSPEGV-ETMELNVRN----DAFVAADS-EKSTQMDVS------------VDVA----
TEEDNKK-DECEAV-TTEVN-VEGVATEDFNSGMDLSDTPIPVSK-D-------------
--------VET--EHAASGEIEGEG-NESDSGSCEEMK-KEMGSHKAQ----MSTEIDSA
R-VKETDIFAS-ASKSEEALIGRLEVNTQSFV----SDIETS-SG-----ERTVNCKTET
SIELNKLDE--AKLSGNEATVGND--TLQEVCFT--SEKVEKLPQCLLVQVAS-ELGAES
NTT-SPEK-LELD--S-FGSVSESPSG--MQ-ARCVWSPLASPSTSILKRGLKRS-QEDE
I-SPVNK--IRRVSFADPIYQAGLADDIDRRCSVVRSH-SSNSSPIIKS---VKTSPTSH
SKHNTTSAKGFLSPGSQSSKFKSPKKCLITEMAQESMLSPT-ESVYPALVNCAASVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL-RVYHEQ
QMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFA-----------------------S
DLIEPVTLDT--PLSKNLVAQISALALQLDSEDLYSYTGSQLFEMHEKLGTMANSIIRNL
QSRWRSPAHENS---------------

------------------------------------------------------------
----------------------------MTARGQSPLAPLLETLEDPSA

PF12231 // ENSGT00390000012204_0_Domain_0 (110, 295)

SHGEQTDAYLT
-----------LTSRMTGEEGKEVILEIERKLPQLYSVLKTHISSQNLELSSAALQALGF
CLYNPKITSVLSVRCKAN------------------------------------------
------------------------------------------------FFIDFTIY----
------RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQNQQEI
ASITEQLMTTNLISELQKLFMNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISTDSNA-SLQGNLSRVTSSPGLNSMTPV
HKGASSPYGTSVTPRMNLSSNLGGMATIPSIQLLGLEMLLHFLLGPEVLNFAKEKKLVLS
LEPLEHPLISSPSFFCKHANTFISAVHDSFVAVGKVA--SDMVINAIWKELIRLVKSVTE
SGIKKERPGSEVLTLLLKSLESIVKSEVFPISKTLVVMEITVEGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-N-NLLEFGVTDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNTKQLESKEHLWRMWSIIVTPLTELINQTNEVNQGDALEHNFSAIYGALM
LPINHIFSVQRFPVVTMKTLLRTWSELYRAFARCAALVATAEENLCCEELSSKIMSSLEN
EGLSDLLFLDRIFHIITVMVDCIDFSPYNIKYQPKVKSLQKP-SDWSKKK-NAPLGKLTS
LFKLLVRMIYSFHTLSFKEVYSD----TLFTIGNSITSILSKVLGHISLPSMIREVFVTL
TRPLALFYEN-AK--LDEAPKVYSCLNNKLEKLLGEIVTCLQFSYTGTYDSELLELLSPL
LCIIFLHKNKQIRKQSAQFWNATFAKVPMLIYPEELKPILRQTKQKFLLLLPGLETVEML
E-ESSGPYSDSTENSQLNVKISGM--ERKSNGKRESFLARTKDKRE-NIK-------PTA
KLKFESSSPKAKSE-ILLEEEKSTDFVFIPPEGTDAKERVLTEHQKEVLKTKRCDIPTMY
N-NLDISQDTLF-SQY--SQEESLEI--STSATKAKEDSKIMS-------EGENMDSDVV
--ILQDVVENCGMNEHLEKSSLS---------------NNECGSVDEASPKILTSN-NDA
RNNTLISSKKTKKTECTSNIDNSLVVS--SSSLSNA--------TVSGTP-SQPTSRRQT
FITLEKFDGSE--NRPFSPSPLDNMSSTVT----VKNNQENTIKADTPLKAKQKEVTVF-
-------------KSDSEKIVNGTKRSG-----RRSGKAD-------QTGNKRSK-LMR-
------------SEQERSTQESPEGMV-ALEN-KPPVLINQTECVSDN-QGNYS-ESTME
YEDTKLKS-TIENVVLSENNTVEEKTVEINLECKENTPPVVIPA-DQMVNEDSQVQ-ITS
NQKTLRRSSRRRSEIIESTIDSQDKENNNQKKERRKDEEKS-LQKSPLQIKDDVLLKQKL
ISEQT--VQENLIEKGNNLNEKTFGETS----------ANAEIEQNKRKPDLESIKSEGD
G-SQDIADKSSEKPIRGRTRYQTRRASQGLLSSIENSESDSSEAKEESSRKKRSGKWK--
--------------NKSNDSVD-IEDQVEKIAKQECIKAENQTHDY---------KASSE
VAIDI--KSQICEKQDESNTVVLRDS--TVSSDLLQVSDDLS-NMY----KEKSKTGKCA
EHS-----FTSPPVPESNLRTRNANKRLHK----RDSSDNCSA--EDSSKVGASDISLLS
ENTLPTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--KSFIGLKNTEDCDVKISETKKTD
VQASVTISET-SKTSLSSEVKVVE-EHHSVNFHLSLKEDNDTINDSLITSETELKANTA-
-QESLPSEMVNFEEE--TCDMDCSEAMSPES-------QEPSDENFK-TVGPCLGDFKVT
SQE--CSLEIKV------GKLEATP---K-KELGLES-F-NIEGNECKV-----------
TESNLEGV-ETMELDARS----DKSEASFS-EQETSKMDIS-----------GESA----
TEENSKRSDESEANTGEELN-A-EATAEEFNSGIDLSDNTAPIKLS--------------
--------AQPEVSEQTADRELERTNDGSDLGSSKEMSVAEVENCAETMIGEVNAETDHV
NETEDGDIAIKTCSKPEEAETKRLNSEIGNFV----SDMLEMSTKEEKF----DSNKTET
DIELKS-EE--TKLDNNQMVVGNI--LQE-VHHI--SDSVEGPSQSLTSETAISELIIE-
DNNASPQKLRELD--PLLVSANDSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPINK--VRRVSFADPIYQAGLADDIDRRCCVVRSH-SSNSSPIVKS---VKTSPTAQ
SKHNTTSTKGFLSPGSRSPKFKSSKKCLISEMVKESMPCPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTPSEIKTLPIRSPKVSNVRKAL-RVYHEQ
QVKSRGLEEIPVFDISEKTVNGIENKSLCPDEERLA-----------------------S
DLIDPVTLE--TPLSKNLVAQISALALQLDSEDLHNYSGNQLFEMHEKLGSMANSIIKNL
QSRWRSPAQEN----------------

------------------------------------------------------------
--------------------------SRLTGEEGKE--FVLEI---GKQLSRLSKVFQVH
-----------IS-------------------------------HQNSELNCAALQALGF
CLHNSKISSGLSESEMERLLSEVNSIAEKTSDKNTRTRALWVLSKQTFPAEIVGKVV---
--------------------------PSIIATLERVFNKEDVHSMVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLLEQAPVQMGEEAVRWAKLVIPLVVHSAPKVHLRGAAALELGMPLLLLKQQEV
AAITEQLMTTKLISELQKLFMTKNETYVLKLWPLFVKLLGKSLHRSGSFINSLLQLEELG
FRSGAPVIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGSHLPANFEQVCVPLIQNTLSIDSNA-PSQGTPSRGAANQSLNSVTSG
QKAGTFPFGSSVTPRMNLSTSVGGMAAIPSIQLLGIEMLLHFLLGPEVLEFAKQNKLVLS
LEPLQHPLISSPSFFCKHANTLIAAVQDGFIAVGKDA--SDAMINAIWMDLIGFVKSVIE
SGNKRERQGSEVLTLLLQALKNIVTSNALPVSKTLVLIEATIKNLPQKVLGSPAYQIANM
DLLN--------GTPALFLIQLIF-HNNLLENGATDERFFLNLETLVGYVLSGPTSPLAF
SESVLGVINQNAKHLKNREHLWRMWSIIVNPLTELINRTNEVNQGDALEHNFSAVYSALI
LPINHIFPAEDFPPPSMKSLLRTWSELYRAFARCAALVATAEENLCCEELCAKIMLGMDD
EALANLPLLDGIVHIITVMVDCIDFSPYSTKYQPIIKSPQTP-TDWSKKK-KEPLGKLAS
LFKFIVRAINSFHRLSSKER-PE----ALLPIGSSIVSIISSVLGHISLPSVIRTIFATL
ARPLALFYEN-SK--CDDRPKIYSSLSNKLEKLLGEIFLCLQSRYTGNYDNELLEQLSPF
LGSIILHKNKQIRNQSAQFWNATFAKATMLMYPEELKPILNQAKHKTLLLLPGFESVDVV
E-ESSGPYSEPTENTQLEAKISGV--KVKSSGKRNSLLSQAKDLKEKNPK-------PPA
KLKLEFSSPKVKNE-ILLEEEKSADFVFIPPEGKETKARTLTEHQKEKLRTKRS-IPLLP
K-QISLTESSLNNKSW--LVAPVFQLLRAPLNKIYITIRQFCI-------QMKTQLVVFS
--SATCQLCDCGQVTSLLCASVP---------------SSSI---------FKNNYYYLA
KLKAPDIDL-PKSFECASLDECSIFCS--IFPLKSAECNMTLFMRCDGLP-SFNIPLNSV
FIRLSVLNSDYLLSTYFEPNTS-----EWN----IRN--ICFCRVDIPVMYNNLDVSQDT
ALF--------SRYSQEESMEKGTLIE-----------EP-------KDNPSEFQIL---
------------GELLM-SSNW-----------VKRTLSSPSELLPCQ-SKHLS---YLA
S-----IT-ASASL-LLTPLLSESVKVGPNLESKENTPPEEIQT-DPMSNEDQGPQ-IAS
NQKPLRRSSRRRSENAECATGSQDKENSHQKKERRKEEEKC-PQKRISQLKDDFSPKQKQ
ASAKVRDEQDDTCRKESNLPEKTTEETT----------SETEINKS-IKKEVENLKSDG-
DSQDSGSDKAGEKPARGRTRYQTRRASQGLLSSIENSESDSSETKEDGSKKKRPGKWK--
--------------NKTRDPLE-DKEREEKIGSQ-EYVASETVSEARSLDVQNKSEMSPE
EDPKISLISQTCEA---------KDG--GNSSTINQCAD-VS-EVGEQNRNGKLKTDTAK
EDS-----RVSPCVSEPVLRTRHAAKSLNM----EDSTV--HS--DR----DFSVISSPS
EKPLPTPECHHKRS-RRVRKSKSCDCCGEKSQSQE--KSFTELKSPDDRQHLNPSEHK--
--KTGAQTTVTAA-ENFQLSPLSE-KKPLK-ETWALKDSLIDSVL-ESEKKERSAGLFQ-
-EPLP-VERVGFENK--TSFS----DGILEK-------QGPTEVDGQADKPRLLNDD---
-DS-LDPLERDPVVEMQTEVPVTSLEEEMNKNGKPEKVA-SPGDELKAPTDKDESEDMDT
HCAEPEET-EGKETDTQC----AKC----E-EADGGGMDTH-----------DSKP----
------KQDEEEMMDAQDAE-PKEIKAEE----MGNPGAESQRAEVEDGDVRGTEAKRKE
EEDVNAQPVKPEKAEAERWELRNGGTKTSQNESNE-------------------------
----NRNLS-------------MKGV----------NK--SLSKV----DLGGTETAREP
RVDF---EK--QRHNNNNKYHNYN--L-ADLG-------CLTFPPP----KSK-FWVAG-
EWEAW-EEEKGAE--KWLLAGDLLKLSDQLNELSFEVHPLSLISYLMLIRSP-RI-IRFI
LYLAHLQ--IRRVSFADPIYQAGLADDIDRRSPVVRSH-SSNSSPTARS---LKIPSNSQ
SKHNTTPTKGFLSPGSRSPKFKSSKKCLMTEMTKESMPSPN-ESVYPALMSCGAPIDIIL
PQITSNMWARGLGQLIRAR--IKTIGDLSTLQQL-NQSLPIRSPKVFSITLPPLLPNTTM
KMKSRGFEEITALDASDKLVNGVDNKPTSPDEERLA-----------------------T
DLVEPASSVTEPQEPKDLLLQINSLALQLTSEALHQYSGSQLFEMQEKLGSMTNCIMRNL
QSRWKSPPHESCS--------------

------------------------------------------------------------
------------------------------------------------------------
---------------MTGDEGKEVVIEMEKNLPRLYKVLKTHISNQNSELSSAALQDLTM
FQVVSNLVIH------------LHQF-----------LRCWIKRHA--------------
--------------------------LSFLA--------------IYSLSF----LGYCF
--------------SYSKDYLRYCELFLN------------------FGYCIFFLY----
-LLNILLCL

PF12231 // ENSGT00390000012204_0_Domain_1 (370, 447)

QKLISELQKLFMNKNETYVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGTPMIKKIAFIAWKSLIDNFALNS---------------------------------
--EVWWYLLMRLGPHLPANFEQVCVPLIQSTIS-DSST-SPPGNSSRVAASPGLSPMTPV
HK-GKEEQMF-----------------------------FFLFKGCEDLCCITEFILVME
-------------------------IEHRY-----LLCLTDAVVNAIWKALISLVNSLTE
SGNKKEKPGSEVLTLLLKSLESVVKSEVLPISKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-SCYIQECGIADERFFLNLESLVGCVLSGPTSPLAF
SDSVLSVINQNAKQLENKEHLXXXXSIIVTPLTELINQTNEVNQGDALEHNFSAIYSALT
LPINHIFSAQRFPVVTMKALLRTWSELYRIFARCAALVATTEENLCCEELSSKIMSTLED
EAFLNLLFLDRIIHIITVIVDCIDFSPYNNKYQPIVKSPQRS-SDWAKKK-KEPLGKLAS
LFKLTVRVICSFHTLSFKETHSD----TLLGIGNSIINMISNLLGHISLPSVIRKIFTVL
TRPLALFYEN-SN--LDEVPKVYSSLNNKLEKLLGEIVTFNITN-TNTLDSNMYIY----
-----------------------------TYFFFFLRPVLREAKQKVLLLLPGLENVEIM
E-ESSASYSDAVTLSL---K------------------------IF-FVK-------LSK
ILKRESSSLRVKSE-PLLEEEKSTDFVLIPPEGKESKERILTEHQKEVLKTKRCDIPAMY
N-NLDVSQDTVFTDHY--SQEDSVQT--PTLTEKPKEDTKE-----------EQMKSDTV
--I-QDALENCGMDEHVKKASFS---------------NNECGFVPKTNPEIMSG-SNEA
RKNSLISSK-KTSTECASSAENSL-VS--SQSISDA--------SISETP-PQTTSRRQS
FITLEKFDGSE--NRPFSVPSLSSMSSNTL----VQNSQENMTTTDNTSKTNKREMMHS-
-------------KSDSEKNLHGIRKSS-----RRLSKAE-------KSASKRSKPLIK-
------------SQQEE-NQELVE-------ENNSPVFFNQTDCSSDG-QTHIS-DSVPE
HEDRRPKL-TLENTVLLENSTVQDKNMGINLESKENTPPAQPPA-DQIVNEDSQVQ-VTP
NQKTLRRSSRRRSEITDAVGDNQDKENSHQKKERHKEEEKL-QGL--LHVKDDVLPKQKL
TYEQT--GQENLLEKESNLHEKACGETS----------VNADIDQSKRKPDLENVNSQGD
S-ALDIVDKSSERPLRGRTRYQTRRLSQGLLSSIENSESDSSEAKEEGSRKKRSGKLK--
--------------NKNNDSID--TEQEEKITEEESGSVTNHTQDY---------KAISE
IDVDK--KPQVLEKG-QSNTIILQDS--KTSVGML------------------VKTTKCL
ESS-----FASSPMPESNLKTRNASKRSVK----QDSD-N--------------KMSTLS
EKNVQTIECHHKRS-RRVRRSKGYENVTTK------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------TKSEMKIEQLNVELDSFV----SDTLEMNTEEEKI----DSNKTET
NIELCKSEE--TNLDDNQMVVG-N--ILLEVNHT--PDKAEKPTESLTSETAVSELVTE-
NINSSPEKLRELD--SLLMSANDSPSA--T-QTRCVWSPLAXXXXSILKRGLKRL-QEDE
ISSPINK--VRRVSFADPIYRAGLADDIDRRCPLVRSH-SSNSSPIIRN---VKTSPTSQ
TKHNTTSAKGFLSPGSRNCKFKSSKKCLITEMAKESISCLT-ESVYPPLMNYTFLLLIL-
------FRARGLGQLIRAK-NIKTIGDLSTLTASEIKALPIRSPKVSNVKKAL-RIYHEQ
QMKSHGLEEIPVFDISEKTLNGIENKS--ADEERLA-----------------------S
DLIDPAALE--TPLSKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPAHENSS--------------

------------------------------------------------------------
----------------------------MTAPAQSPLAPLLETLEDPSAPHGEQTDAYLT
-----------LTSRMTGEDGKEVIMEIEKKLPQLFRVLKMHISSQNSDLCSAALQALGF
CLYNPKITSGLSETDTQELLLKLNDSV-KSPDKNVRTRALWVLSKQTFPAEVIGKVV---
--------------------------SNIIDSLEIVFNKGEMHSAVVDYEALNVII----
------

PF12231 // ENSGT00390000012204_0_Domain_1 (307, 440)

RLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEI
ASITEQLMTTKLLSELQKLFMSKNETYVLKLWPLFVRLLGKTLHRSGSFINSLLQLEELG
FRSGAPMIKKIAFIAWKSLIDNFALNP----EILCSAKRLKLLMQPLSSIHVRTETLALT
KLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISIDSNA-SPQGTSSRVAASPGLNPITPI
HK-GASPYGTPVTPRMNLSSNFGGMATIPSIQLLGLEMLLHFLLGPEVLSFAKQNKLVLS
LEPLEHALISSSSFFSKHANTLITAVHDSFVAVGKDA--SDAVVNAIWKELISLMKSVIE
SGNKKERPGSEVLTLLLKSLESIVKSEVFPASKTLVLMEITIKGLPQKVLGSPAYQVANM
DILN--------GTPALFLIQLIF-NNNLLEYGVEDERFFLNLETLVGCVLSGPTSPLAF
SDSVLNVINQNVKLLQNKEHLWRMWSIIVTPLAELINQTNEVNQGDALEHNFSAIYGALT
LPINHIFSVQKFPVATMKTLLKTWSELYRVFARCAALVATAEENLCCEELSSKIMSCLED
SSFSNLLFLDRIIHIVTVMIDCIDFSPYNIKYQPKVKSPQRP-SDWSKKK-KEPLGKLAS
LFKLIVRVIYSFHTLSFKEVHSD----TLLTVGNSIISILSNVLGRISLPSMIRKIFATL
TRPLALFYEN-LK--LDEVPKVYSCMSNKLEKLLGEIIACLHFSYTGTYDSELLEQISPL
LCIIFLHKNKQIRKQSAQFWNATFAKVTTLTYPEELKPVLRQAKQKFLLLLPGLENVEIM
E-ESSGPYSDSTENSQLNMKISGM--ERKSSGKRDSFLAQTKDAKE-NKK-------PPV
KLKLEPSSTKTKSE-MPLEEEKSTDFVFIPPEGKEAKERILTEHQKEVLKTKRYDIPVMY
N-NLDVSQDTLFS-QY--TQEESMEI--PPLTEKSTEDTKVIY-------KEEKTERDIV
--IPRDVTENRDTDEHLEKASLS---------------DNQCGSNDETSPELPSS-NNDS
RKNALISSK--KTTECSSSVENTSGVS--ISSVSNA--------IISGIL-PQPTSRRQT
FITLEKFDGSE--NRPFSPSALNNMSSTVT----VKNNQEVMDKIDNPPKAKKREMALE-
-------------KSDAEKIAHGIKRSS-----RRSSKAE-------QTGNKRSKL-LR-
------------SDQEKNTQESIDGTV-VLEN-NPPGLLNQTECVLDN-QAHLS-ESTME
DEDTMLKP-TIENAVLLENSTVEEKTLGISLESKENTPPAIKPA-DQMVDEDSPVQ-ITP
NQKTLRRSSRRRSEIAEPTPESQEKENNHQKKDRRKEEEKT-LQKSPLHVKDDVLPKQKL
IAEQT--LQENLIDKGNNLHEKTFGETS----------TTSEIDESKKKLDLENIKSEGD
S-AQDIVDKSSEKPVSGRTRYQTRRASQGLLSSIENSESDSSEAKEESSKKKRSGKWK--
--------------SKSNDSVD-IEDQEEKVIKQECVNVENQTLDY---------KANSE
VGRDL--KPQICEQKDENTVVTLKDS--TVSSDVLQVSDDVS-TAD----EGKSKTNKCT
EYS-----VSDPSVPDSNLRTRNASKRLQK----RDSIENN-M--GESSKIGTSDNSLLS
EKTLQTLECQHKRS-RRVRRSKGCDCCGEKSQPQE--K-FIGLKSTENYDIKASETKKTD
THTPVTVSET-SKANLCSEVKLLD-EHNCVNFHLGLKEENDAVNDSLIISESELKENTS-
-QNPLPSGVVNFEEE--TCDMDSEEATPLES-------QEPSNKKCR-TVSPCLGDSKDN
SLE-CSILEIKE------EKSEAVL---E-KELSIENIV-NVETDACKA----------N
AKSNPE-V-EAIELGVKI----DKSEASFS-EQESTET-----------GISEEEV----
MEINSDRSDESDAEAAEKLK-AEEAVTEEFNSVVDHYDNTT--EMS--------------
--------AVVEIPEQTAVGELDERSDESGPGSSEGMN-AEMETCEETVIGEVSAEADQV
NETEGQDSTNRISTKPVQAETETSSMEVSSFV----LTTLGMSTEEGKD----DSNETET
KNELSKSEE--AVSADSQMVG-ND-EILQEAHHT--SEKVEDTSQSLTSETAISELITE-
DNNASPQKLRELD--PLLVSANGSPSG--M-QTRCVWSPLASPSTSILKRGLKRP-QEDE
ISSPVHK--VRRVSFADPIYQAGLADDIDRRCSIVRSH-SSNNSPIVKS---VKTSPTAQ
SKHNATSTKGFLSPGSRSPKLKSSKKCLITEMAKESMPGPT-ESVYPALVNCVAPVDIIL
PQITSNMWARGLGQLIRAK-NIKTIGDLSTLTASEIKTLPIRSPKVSNVKKAL-RIYHEQ
QVKSRGLEEIPVFDISEKPVNGIQTKSLPSDEERLA-----------------------S
DLIDPVALE--TPLPKNLVAQISALALQLDSEDLHNYSGSQLFEMHEKLGSMANSIIKNL
QSRWRSPTHENSV--------------

------------------------------------------------------------
--------------------------MSGTVSAAAGLRPLLETLQDPAAPAGDL

PF12231 // ENSGT00390000012204_0_Domain_1 (115, 504)

TDAHLS
-----------LVNRLSGEEGREFVAAVRKHFPRLCKVFKAHISSENSELSNAALQALGF
CVFNSKITSELSASEVEDLLSTLNSIAVKTSDKNTRTRALWVISKQTFPSEIIKKEV---
--------------------------SSLISTLETILTKGDVQSMIVEYEALNVVI----
------RLMEQAPAQMGEEAVRWAKLIIPLVVHSAHKVQLRGATALEIGMPLLLQKQQEV
AAVTEHLMTTKLISELQKLFSTKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELG
FRSGSPVVKKIAFIAWKSLIDNFALNP----DILCSAKRLKLLMQPLSSIHVRTEALALT
KLEVWWYLLMRLGPQLPANFEQVCIPLIQSTLSVDSAA-ALQGTPSRVPSNPNS--ANPP
QKPGPYPFASPATPRMNLNSSTAGLVAIPSIQLLGIEMLLHFLMGPEVLEFAKRNKLVLS
LEPLQHPLISSPSFFCKHASTFINAVQDGFIAVGKEV--PESMLNSIWKDINGHVKAAIE
SGNKKEKQGSEVLTMLLQALKNIVRSNSLPVQKILSLIDITVKELPPKVLGSPAYQIADM
DLLN--------GTPALFLVQLPF-HNNLLEWCVTDERFFIILETLMRYVLSGPTSLLAF
SESVLCVINQNAKQVENKEHLWRMWSIVVNPLTDWINRTNEVNQGDALEHNFNAVYNALL
LPVSHIFPVQEFPQPTMKSLLRAWSDLYRAFARCAALVATAEENLCCEELCAKIISGLEG
ETPVMSAMLDGLTHVVAVMVDCINFAPYGTKYQPKNRSPQTP-TDWSKKK-REPLGKLSS
LFKLLVMLLDSFHALSSEETCPE----PLASVGHSLIAVLHNIISHVSLPSMIGTMFAVF
SKPLAVFYEK-TK--LADVPKAYSNLNSKLEKLLAEIILCLQSHCMGCYDSELLEQLSPL
LCVIFQHKSKQMRKQCANFWNTTFAKAASLTYPEELKPVLSQAKQKMPLLLPGFESIEIA
D-EQSGPFSDEAENSQWDAKLSGM--EVNLGQKRDSILAQTGELKNEVKDKSDNVQVTSA
KLKLEFSASKPK-SDVLLEEEKSVDFVFIPPE---TKARILTEHQKEVLRSKRVGIPAMY
N-NLDSSQDTTLFSQYTQSQEDSLEK--SP-LENAKEDFKNNP-------QEENGKSESC
IADSDGNTGDCKVDNPLEDV---KEKSAYHIEKNSN--SEEESS-RGDRTGIIGEE-SSV
GEALEKSGTETASKESLVGNENTSAIS--CSSTSSD--------VICGTP--QPASRRQS
FITLEKFDSSE--SRPFSPSALNSVSEVSQSAPVPD-KQGNINVCKTGRKPGKSGEESRK
SSQS-------------EQISAAKRR-LT----RRQSKME-------QQGNQQAKLVTN-
------------SEQEKGAQESFVSN-------SVENSPESPCSMEDTERVLTAQPQPVS
SPEPDIKK-AEAVMAEIE------KVRAFEMDSKENTPPKTAVSSEQVMGDGSQGPHASL
SQKTLRRSSRRRSENAEMAAGSQDKEDGYQKKDKRKEDEKA-LQKKVPQTKEDASQKQKA
VCGKASEHAIK---KESSLPERSAAEDLGSKEPPAAKGADEEANRSAGKPEDTL-KSDS-
EGQDCSSDTVSEKK-RERPRYHTRRSSQGLLSSIENAEADGSETKKESLKKK-SGKTK--
--------------NKSDS-LE-GKRKDVQPESQSHGVSSQ-VDESKNLSGMNESELSSE
VSTDAALMS---APSDVKNQVLLAGADEAEGSASSRTS-----PSTQNVSVEQSKA-GVL
PES-----FSDPRVSDEVLKGDEN-KCIEK----QSSVEQHSSVQPENVQG-A-NTSGSD
LSSLQMQDCQHKRS-KRVRKAKSCDCCSKRVKQQT---SLSESKSEDPREL--IEPQATP
VQMAVSTAEV-SGSSNLEESLSIT-P-CAMSTPLPPAKESGMLSLERERTG-----EDN-
---------------------LQGNSGVMK--------EE-AEN----------------
-------------------------------------------------P----------
AHTAGEVSDPVVEIKVKEEV--DGNDRAE--QCVSVSECASDEPSDSSVAAG--------
----D--QSEEKAAVEKEEE-SQHGEMEEVPE----------------------------
-------------------------------------ADGSKP------------ETKQM
---------------------DEL---EGNRDGKEEA---ENA-------LEEVCIT---
----------------------PDNEMRE----ELLEAEITVPENVAV--GNKDVVVEN-
KSADSPQKPEGLDS---FTSVNGSPSG--V-QARCTWSPSASPSTSILKRGVKRH-HEDD
SLSPANK--IRRVSFANPIYQEGLADDIDRRSPVIRSH-SSPSSRSLKI---L---SNIQ
TKHITTPTKGFLSPGSRNPKFKSSKKCLMTEMVKESLPSPT-ECVYPALAGCKAPVDVIL
PQITSNICARGLGQLIRAK-NIKTVGDLSALTASEIKTLPIRSPKVSNVKKAL-RGYHEQ
QVKSRGCEEIGALEDGERTVNSAEDKSPPVDEEKLA-----------------------T
DLGEAIALSSSSPPPADLLSQMDLLAAQLTSEDLRSYPGSRLFEMQEKLASMSDCIMKTL
RSRWRSPPHDSAE--------------