Query Results 

------------------------------------------------------------
----------------------------MAGEGPRTEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYAT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQ----------------SS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDNIQKSEL--GNQSPSTS---S
R-PVTGQPQN-ASFGKR-N------------C-WWLFPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--ERGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGFRDPQE--DSE

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVNSQAL
KTTVTASTT---E-------EA--QAAYSASSLNK-----------DHQEIETIGPES--
------------------------ADT-G----------------DTS-EKPDETNLGDY
-PKHKT-----------------EHENNPSFQD--GEQG-HHVSSERSLGEEAL---DPD
PAHSPSGQ--GRADTQLDSSPAAFPE--------EVSNRTRAS-----QEPPAAIALLAQ
SPG---------------------------------------------------------
------------------------------------------------------------
-------LEGQDTLRRR----QPVP-E---------PENHQQETQ------------KLE
ENNDN-AQDAIRKIKEK-VFQ-------CYGPIFVGFMVAIIM-LS----L---LGY---
CSFSAQQVPQKPALEAFLAHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATLI
FTAARDGRET-LKCLSHHVADAYTSSQKV--SAIEIDGAGRTSQDSDTVKLLVDMELSNG
FENGQKAAVVHNFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNANTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVQEGWGMYVTPRAPIREGRGRL
APQNGGS-SDAPAYAT-PLSRQG-RREVRFSEEPPEV--YGDFEPRV-AKERSPV-----
--GK-RIRLEEFRP--------------DSAKEEVRESAYYLRSRQR-RQPRPQEAEEMK
TRRAIRLQQQH-----SEQSPLQPSPATTRRGLRDSHSS------EE---DESSS-----
------------------------QSDLSQMISEK---TV-----RSTQE-AP-VLS---
------------------------ED--L-----VISLCRPPLRNPRS------------
----EA----------------TSVQQKVIFSE-EG

PF05609 // ENSGT00390000012166_0_Domain_3 (457, 1019)

ETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTP
VKTRSWD----SDESGG--------------------QN-FTAHDKQPS-VLSS-GY---
--QKTSQKWAPQTARIRTRMQTSSPGK-SSVYGSFSDDDSIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASSGKR-N------------W-WWLLALLA--ALAYGSF---WFFST--
-----PEVETA-AVQEFQNQMNQLKNKYHGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTGKATQDSDTVKLEVDQELSNG
FTNGQNAAVVHRIESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPNSYNHMDS-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGPRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQHY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLCRPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-KGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGALECGI-NFQSMGNY-------------LLIYVFAS

PF05609 // ENSGT00390000012166_0_Domain_3 (653, 1019)

GS-GY---
--QRTLEEWAPQTARIRTRMQN----------------DNIQKSEL--GNQSPSTS---S
R-RK--------FVYSR-N------------C-WWLLPLIG--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MNDRGLRDPAE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NVSLVNSQAL
EIAVIANTS---K-------EA--QGPDSSSGLK----------------VETVGPRS--
------------------------TDK-D----------------DQE-ENPEEANYGSC
-PKGQP-----------------ELEDNQNLQD--EEQG-HHPP-SGRLSSDLLDL--EE
PNHPPSDK-VERTDTHLGVSSAALPEDMHDESSGEP----------SEQNPLAQ------
------------------------------------------------------------
-----------------------------------------------------ELQEAPS
SGHPSARLESSETLRRR----RLVP-E---------TRIHQQETQ------------RFE
ENKDI-GKDIKRKLNRKNMLS-I-------XXXXXXXXXXXXXXXXXXXXX---XXX---
XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXX
XXXXXXXXXX-XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAAFKDVALVLTV--EE-ETLEASVGPRE
TEEKVRDLLWARFTDSSAPTSYDHMDS-DKLSGLWSRISHLVLPVQPVSHI--EQEGCLL
SQ-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVNSQAQ
ETTIIASNA---E-------EA--EILHSACGLSK-----------DHQEVETEGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKT-----------------EDENKQSFLD--GGKG-HHLP-SENLGKEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPVILVVLV---VAVVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPTSFNHMDS-DKLSGLWSRISHLVLPVQPVSSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MADEGRRAEPAGERWGMYVTSRAPLREGRRRR
ASQ-DGGGGDALAYGTPPSR-QG-RREVRFSEEPPEV--YGDFEPQM-AKETSPV-----
--GR-QTPPKEFQP--------------DSAKEEGRESAYYLRSRQR-RQPRPQAVEEMN
TRRTARLLQP-P----L-----QPSPAMYYI---LDFNSYH-VFSLE---DEPSS-----
------------------------QTVTNQTVSKKS---------VRTQE-VP--VTS--
------------------------ED--P-----VISLCRPPLRSTRS-GKGL-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---FYLL

PF05609 // ENSGT00390000012166_0_Domain_3 (728, 1019)

PQN-EYFFKK-K------------W-FLCLLVVINVF-VLWNF---SFFHT--
-----PEVETT-AVQMFQNQMKQLRNKYQGQDEKLWERSLTFLQKHLNSSNPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDVVKLEVDQELSNG
FTNGQNAAVVHRLESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLGTSLGLKE
IEEKVRDFLKVKFTSSSTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MMDSGLRDPPE----DSR

PF05609 // ENSGT00390000012166_0_Domain_0 (286, 375)

LA---SDPSVNSQEQ
ETTVTANST---E-------EA--QTSCPASGLNK-----------DHQELEAESPASPD
TELEAEGP--ASPDTEREAEGPENPHT-D----------------EKS-KSLDEANFGKY-PKDKK-----------------EDENNLSFQD--GEQK-NHLP-LENLGEEPL---NSDANCFPSGR--GRTDENLGSSCAFFPE--------ELNYETEAS-----QEPSTVVSQEAQSAG-HSIEE------------------------------------------------------------------------------------------------------------------------SQDSLRRR----WPAP-E---------TESHEHETR------------TLGETKEM-A-RDTTKIKKK-NVW-------NYGCMLFGFLIVF--------SG---YCY---YSSPAQQVSQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PSEPATIIFTAAQEGRET-LKCLSHYVADAYTFSQKV--SAITINGAERASQDSDTVKLLVDLELSYGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEANVGPRETEEKVRDLLWAKFTNSNTPSSYNHMDP-DKLSGLWSRISHLVLPVQPVRNI--EEQGCF------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (371, 1018)

ASPDTEREAEGPENPHT-D----------------EKS-KSLDEANFGKY
-PKDKK-----------------EDENNLSFQD--GEQK-NHLP-LENLGEEPL---NSD
ANCFPSGR--GRTDENLGSSCAFFPE--------ELNYETEAS-----QEPSTVVSQEAQ
SAG-HSIEE---------------------------------------------------
------------------------------------------------------------
---------SQDSLRRR----WPAP-E---------TESHEHETR------------TLG
ETKEM-A-RDTTKIKKK-NVW-------NYGCMLFGFLIVF--------SG---YCY---
YSSPAQQVSQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PSEPATII
FTAAQEGRET-LKCLSHYVADAYTFSQKV--SAITINGAERASQDSDTVKLLVDLELSYG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEANVGPRE
TEEKVRDLLWAKFTNSNTPSSYNHMDP-DKLSGLWSRISHLVLPVQPVRNI--EEQGCF-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MSQSLKSQNTNMSDSDCRDPAG--DSQNV

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1019)

LE---NDPSVNSQAP
DTKVTPSNT--AEVTLSNTAEA--RTPHPTSDLRE-----------DCHEIGARGQEH--
------------------------VDT-G----------------DRS-GSPEEQALEKP
-PLGKA-----------------ELESSPSPQD--TEHG-HHPH-SEHAGRDAL---DLD
PDCSQIDL-GGRTDACLQSSSAAPPE----------------------------------
------------------------------------------------------------
-------GAG---DRGE------ADAHLESSSAAPPEGAGDRGEAAQELLAVDS-THGQS
LGHSNTGPGSQDSLRRR----LPAP-E---------AGRHEEETE------------LAE
EKQEVTQDTTLRKTDKK-SLW-------TYGSMFLGCLIVAVV---L-SSV---NSY---
YSSPAWQVPQNPALEAFLVQFSQLKEKFPGQSSFLWQRGRKFLQKHLNVSN-PSEPATII
FTAAREGKET-LKCLSYHVANAYTSSQKV--TAVSIDGAERALQDSDTVKLLVDLELSNG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEAGVSPRE
TEEKVRDLLWAKFTNSESPTSYSHMDS-DKLSGLWSRISHLVLPVQPVRNI--EERGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------MEN----
------------------LLKYRKYEEIFSIKLVNFF-SLASQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDSSINSQAQ
DTTVTPSNA--AK-----TEEA--QTPHPASGLNE-----------DHHEVGAHDPES--
------------------------ADT-R----------------GKS-ESPDEGQLEKH
-PKAKT-----------------EREDNLNSQD--GEQG-NHLS-SEHPSEELL---DPD
TNCSPSNGDAGREAACSESSMATLPE------GADVSSGA-------SQELPTSDSPDTQ
------------------------------------------------------------
-----------------------------------------------------------S
PGHCSEGPENQASVRRR----LPAP-E---------AGSHEEETQ------------IVS
ENEEV-PRDPIEKINKKKYLW-------NYAPMFFGGLVVAFV------SV---NSY---
YSSPAQQVPPNPALESSLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNVSN-PTEPATII
VSAARKGKET-LRCLSHHVADAYASSQRV--SAISIDGAERALQDSDTVKLWVDLELSYG
FEN------VHHFESLPAGATLIFYKYCDHENAAFKDVALVLTVL-DE-ETLEANVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAESVIEGWGLHVTPRAPLREGRRRL
APELGGG-SDARAHGTPSPSRHA-RREVRFSEEPPEV--YGDFEPPV-AKDRSPM-----
--GK-RIQLKEFRP--------------QATKEEVRERAYNLRSQPR-RQPRLQEAVE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MR
TRRAARLQQE-------NSPQPPPQPVMTRRRLRDSHSSE------E---EELSP-----
------------------------QTVVSQTVSKKT---V-----RRTQE-TSV--MS--
------------------------GD--S-----VLDLLRPPLRSPRS-E----------
-----A----------------TSVPQKVNFSE-EGDTE------------------EDD
QDVSDSA-----------------------------------------------------
---------------------------------------------------------VTS
VKVRSGE----SLDSGDQTSRP--GQHLESFWQSSQSQ-DFKALDKQHS-VPIS-EH---
--QKNLQERVDQTTRRRTKMPTSAPDK-CFNILLLSLDDSFQKSEF--GNQSPSTF---S
Q-HMTGQPKN-ASFVKM-K------------WWWLPIPVLL--ILVLGSW---WYTHV--
-----PEVEGT-AV-EFQNQMKQLMIKYQGQDEKLWKRSLTFLEKHLNSSQPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSHRSV--RAIRIDGTGRATEDSDAVKLEVDQELSNG
FQNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPTSYKHMDP-DKLSGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDRGLRDPPE--DPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDPSLNTQ--
ETTVTTSTT---E-------EA--QTPDPAPGLNK-----------DHQEVETVGPGS--
------------------------TDT-D----------------AQS-ENPDETDYGKY
-AKVT------------------EGENSQSFQG--GEQG-HQLP-SESVSEDPV---DPE
PKCSPSDK-VGRTDVHIVGSSAAFPE--------HVSDGAGAS-----QEPPVVDPQDAQ
SPG-HSSAGLES------------------------------------------------
------------------------------------------------------------
----------QHTLRKR----LLAP-E---------AERHQQETQ------------ELE
ENKEKNAQDTVRRTDKK-DFL-------SYGSIFLGFLVLTIV-LLS-S-V---NSY---
YSSPAQQVPKNPALEAFLVHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASH-PSEPATII
FTAAREGRET-LKCLSHHVADAYTSAQKV--SAIHIDGAGKTLQDSDKVKHSVDKELSSG
FEKGQKAAVVHRFESLPAGSTLIFYKYCDHENAVFKDVALVLTVLLEE-ETLEASVSPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCFV
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEPVWQGWGVYVTPRAPLREGRPRL
APQNGGG-SGAPAYGS-A-SRQG-RREVRFSEEPPEV--YGDFEPRV-TQERSPG-----
--GK-RTSLEVFRP--------------DSAKEEVRGSAYYLRSRQR-RQPRPQEAEEMK
TRRAARLQPQD-----SQQPPLQTSPVTTRRGLRDSPSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------QTVLSQTVSKK---TF-----RRTQE-AP-VVR---
------------------------DD--P-----VISLCRPPLRSPGS-E----------
-----A----------------TSVQQKVNFSE-GGETE------------------EDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VAT
LKVRSRD----SDESGDQTTRS-SGRYQESFWQSSQSQD-FRAHNKQPS-VLTS-GY---
--QKPSQVWAQQTARIRSRMQTPSPGK-SSVCGSFSDDDSIQKSEP--GNQSPSTS---S
Q-QLTRQPKN-VSFVKI-K------------W-WWLLFLIA--PLAFGSL---WFFRT--
-----PDVEASAAVQEFQNQMNQLRNKYQGQDEKLWKRSLTFLEKHLNSSHPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGASKAAQDSDTVKLEVDQELSSG
FTNGQNAAVVHRFESLPAGSALIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKAKFTSSNTPDSYDHMDP-DKLNGLWSRISHLVLPVQPENAL--RRGICL-
---------------------

------------------------------------------------------------
----------------------------MADEGRRPELAGEGWGRYVRARAPIREARLRF
APQDGGG-SDASAYGT-PTSRQG-RREVRFSEEPPEV--YGDFEPRG-SAERSPV-----
--GR-RTPPEKFRP--------------DSAKEEVRERVYNLRSRPP-RQPRALETEEMK
TRRAAAIQQHS-----QQPPPPQSSPVTTRRRLRESLSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_2 (290, 612)

-DEPFS-----
------------------------QNVISQTK---K--TV-----RKMHE-SP--VTS--
------------------------ED--P-----VISLCRPPLRSPRS-DSTYKTNGNTK
TTELED----------------ASAQQKVIFSE-EGETE------------------DDD
QDSSNSD-----------------------------------------------------
---------------------------------------------------------ATT
SKVRSRD----SIESRGQ---------------------DFTTLDKQPS-VLSS-GY---
--PKNTQEWREQTTRMRSRIP----------------NDSRQKSEP--RNQSLPAS---T
Q-QVVEQPQN-ESFVK--K------------WRWWLLCAVV--VLAFWMF---PFIHT--
-----PEVKTT-AAQEFQNQMNQLMTKYQGQDEKLWKRSVTFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKATQDSDVVKLEVDRELTNG
FRNGQNAAVVHRFESLPAGSALIFYKYCDHENAAFKDVALVLTVLLED-KTLGTSLGLKE
IEEKVRDFLKVKFIDSSTPSSYNHMDL-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---SDPSINPQAQ
ETTIIPSTA---E-------EA--QTLHPAAGLSK-----------GHQDIETIGPES--
------------------------VDT-G----------------DKS-ESPDEANVRKH
-PKDQT-----------------EHENSQSFLD--GEKG-HHLP-SESLSEEPL---DPD
PSHSPSDK-LGRADAHLGSSSAALPT--------EVTDGMGAS-----QEPPAADSQEAQ
SPG-HSSVGQEG------------------------------------------------
------------------------------------------------------------
----------KDTLRRR----LLAP-E---------AGSHPQQTH------------KLE
EIKEN-AQDTMRKTNKK-NIW-------NYGPVFLCLLVGA---VVL-PSV---YSY---
YFSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGQKFLQKHLNASN-PTEPATII
LTAAREGRET-LKCLSHHVADAYTSSQKA--SPIQIHGAGRTWQDSDTVKLLVDLELSSG
FENGQKAAVVHNFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWSKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------FKKKKEK

PF05609 // ENSGT00390000012166_0_Domain_3 (809, 1005)

KEKDEKLWNRSLTFLKKHLNNSHPQPQPSILL
LTAVRDAKEA-LQCLSEQIADAYSSLCSV--HAIQIDRTDKAVQDSDTVKLE----LNNG
FKNGQNAAVVPCFESLPTDSTLIFFKFCDHENAAFKDVALVLTVLLEE-ET-GSSLGLKE
T-EKVKDFLRAKFT----PSSYHHMDP-DKLSRLWSHIFHLVLPV---------------
---------------------

PGGGSDWEQLTQTRPCLCH-SPAEPPWAQRQVRSAAATTRAAARATLSCLPDRRDHSPTT
R--HRCPRQEHLAAPKRASPPTQDTSTAMAGEGRRAEPVGEGWGVHVTPRAPIREGRRRL
SPQDGGG-GDARAHGAPSSPRQG-RREVRFSEAPPEV--YGDFMSRL-TKEKSSV-----
--RR-QTPPEVFRL--------------DAENEEVIGSAYNLMSRQR-V-----PPRPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (240, 1019)

K
AAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------XX---DDPFP-----
------------------------QSVSSQSVSKKT---V-----RT-EE---VPEEK--
------------------------EV--L-----TRSLHRPPLRNSRSXXXXXXXXXXXX
XXXXX-----------------XXXXXXXXXXX-XXXXX-----------------XXXX
XXXXXX------------------------------------------------------
---------------------------------------------------------XXX
XXX-----XX-XX---XXXX-----X-X----------------XX----XXX-------
--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDNIQKSAF--GNQSPSTS---S
Q-QGSEQPKT-ASFFQI-K------------W-LLPLLLVGISVVAIF-Y---FT-PL--
-----PEVETT-AVKQFQNQMEQLRNKYQGQDEKLWKRSLTFLEKHLNSSQPQPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRINGADKAAQDSDTVKEEVDQELSNG
FRNGQNAAVVHHFELLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLETSLGLKE
IEEKVRDFLRVKFITSDASSSYNHMNA-DKLSGLWSRISHLVLPVQPENAL--ERGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPS-NSQAQ
ETTIIASTA---E-------EA--QTLHSAAGLSK-----------GHQEVETVGPES--
------------------------VDT-G----------------DKS-ESPDEANVGEH
-PKDQI-----------------EHENNRSFLD--GEKG-HHLP-SESLSEEPL---DPD
PSHSPSDK-LGRADAHLGSSSAALPT--------EVSDGMGAS-----QEPPATDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-ARDTMRKTNKK-SIQ-------NYGLVFLGLLVGA---VVV-TSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPVQIDGAGRTWQDSDTVKLLVDLELSSG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWSKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAEEGRQAEPVWARWGVRVTPRAPLREGRPPL
APQNGGG-SGAPAYGT-P-SRQG-RREVRFSEEPPQV--YGDFEPRV-TKERSPG-----
--GK-RTSLEVFRP--------------DSAKEEVRESAYYLRSRQR-RQPGPQEAEEMQ
TRRATRQ-QQY-----SQQPRLQTSPVTTRRGLRDSPSS------EE---DEPSS-----
------------------------QTVLSQTVSKK---TV-----RRTQV-AP-VVR---
------------------------DD--L-----VISLCR

PF05609 // ENSGT00390000012166_0_Domain_3 (401, 1019)

PPLRSPGS-E----------
-----A----------------TSVQQKVNCSE-GGETE------------------EDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSRD----SDESGDQTTRS-SGQYRESFWQSSQSQD-FIAHNKQPS-VLTS-GH---
--QKPSQVWAKQTARIRGRMQTPSPGK-SSIYGSFSDDDSIQKSEL--GNQSPSTH---S
Q-QLTTQPKN-VSFVKI-K------------W-WWPLFLIA--PLAFGSF---WFFCT--
-----PEVETTAAVQEFQNQMKQLRNKYQGQDEKLWKRSLTFLEKHLNSSHPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGASKAAQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTSSNTPNSYNLMDP-DKLNGLWSRISHLVLPVQPENAL--RRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGPRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESSYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSKPGMVAHTCNPSTLGGS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIHGSFSSDDNIQKSEL--GNQSPSTS---S
R-QMTGQPQN-ASFGKR-N------------C-WWLLPLIA--ALASGSL---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MSQTLKSQDTNMSDSGYRDPVE--DSQNV

PF05609 // ENSGT00390000012166_0_Domain_1 (286, 519)

LG---NDPSVNSQAQ
DPIVTPSNT----------VEA--QTLHPTSDLKE-----------DHHEIGAKGQEH--
------------------------ADT-G----------------DRA-ESSEEPALEKP
-PLDKA-----------------ELERSPSSQD--TEQR-HHPY-SEHVGGDTL---VLD
PNYSQSDL-GGRADAHLESSSAAPTE------GAGEGGEAGAHLESSCAALPVGADEGGR
-----ANAHLESSSAAPTEGAGEGGEADVHLESSSA--------VPPEEAHLESSS-AAP
----S-EGAG---EGGE------ADAHLESSSAAPSEGAGEGGETAQNLLAVDS-TDAQS
PCHSSAGPGSQDSLRRR----LPVT-E---------AERHEEETQ------------LVT
EKEEVAQE-TLRKTEKK-SLW-------TYGSMFLGCLIVAVV---L-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFSQLREKFPGQSAFLWQRGRKFLQKHLNASN-PSEPATVI
FTAAREGKET-LKCLSYHVANAYTSSQKV--TAVSIDGAERALQDSDTVKLLVDLELSYG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVSPRE
TEEKVRDLLWAKFTDSGTPSSFSHMDS-DKLSGLWSRISHLVLPVQPVKNI--EERGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLGEPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLQ---SDPSINSQAQ
ETTVTESTT---E-------EA--QTPHPASGLNT-----------DHQEIETIHPES--
------------------------ADT-V----------------DES-ESPDETNLGDY
-PKDKT-----------------ECGNNQSSQD--GEQG-HQVP-SESLGEEPS---DPD
PDGSASGK-EGRADTHLESSSAAVPE--------EVSDRIGAS-----QEPSAAGIQAAQ
SPG-HSGVGLES------------------------------------------------
------------------------------------------------------------
----------QDTLRRR----LLLP-E---------AESRQPETE------------KLE
ENKEK-AQDAIIKISKK-AFW-------SYGPFLLGFLVVAFV-L---SFV---NSY---
HSLPAQQVPQNPALEAFLAQFSQLEGKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATVI
FTAAREGRET-LKCLSHHVADAYTSSQNV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHNFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
KS-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQGVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQDAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSTPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAGEGQRAEPVWEGWSVSVTPRAPLREGRPRL
APQNGGG-SGAPAYGT--PPRQG-RREVRFSEEPPEV--YGDFEPRV-TKERSPG-----
--GK-QAPLEAFRP--------------DGAKEEVRESAYYLRSRQR-RHPRPQETEQ

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MN
TRRATRLRQQH-----TQESPVQSSPVTTRKGLRDSHSS------EE---DEPSS-----
------------------------QTVLSQTVSKKT--D------RRMQE-NPVLVVK--
------------------------ED--L-----ISSLCRPPLRSPRS-EAT--------
-----------------------SI-QQVDFSEGDIYM--------------------ES
ILINIKS-----------------------------------------------------
---------------------------------------------------------MHS
VAFKSRA----SASQFLDQISRSSGQYQESFWQSSRSQD-LIAHNRRPS-ALSL-GH---
--QKNSEEWVKQTTGIRTRNQTSPPGK-SSIYDSFSDDDSNQKSEF--RNQSPSTF---T
Q-QLTRQPKN-ASFVKM-K------------L-WWPFFIIA--LLALGSF---WFFYT--
-----PEVETTAAVQEFQNQMNQLRSKYQGQDEKLWKRSLTLLEKHLNSSHPRPQPAVLL
LTAARDAEEA-LKCLSEQIADAYSSFWSV--RAIRIDGAGKAAQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSDTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENTL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDRGLRDPPEV-DPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDPSLNTL--
ETIVTTSTT---E-------EA--QTPDPAPGLNK-----------DHQEVETIGPGS--
------------------------TDT-D----------------AQS-ENPDETDYGKY
-AKVT------------------EGEKSQSFQG--GEQG-HQLP-SESLSEDPV---DPE
PKCSPSDK-VGRTDVHIVGSSAAFPE--------HVSDGAGAS-----QEPPVVDPQDAQ
SPG-HSSAGLES------------------------------------------------
------------------------------------------------------------
----------QHTLRKR----LLAP-E---------AERRQQETQ------------ELE
ENKEKNAQDSIRRTDKK-DFL-------SYGSIFVCFLVFTIV-LLS-S-V---NSY---
YSSPAQQVPKNPALEAFLVHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASH-PSEPATII
FTAAREGRET-LKCLSHRVADAYTSAQKV--SAIQIDGAGKTLQDSDKVKHSVDMELSSG
FEKGQKAAVVHRFESLPAGSTLIFYKYCDHENAVFKDVALVLTVLLEE-ETLEASVSPRE
TEEKVRDLLWARFTNSNTPSSFNRMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCFV
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------CQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLED---VPSVNSQPQ
ETTVI----------ASVTRDAQ--TPHPATGLN-----------IDHQGVDIIGPGSTD
T-----------------------GDE-P----------------ERP-DET---TGGNY
-PKDET-----------------EHETSWSSQD--GEED-RHLH-AGSPSTKVL---DLH
PTCSP----------S--DKEERAG----------------AHLGS--------------
----------------------------------------------------HEESSVRT
T------ASR---E------------PPASDSQDVPSPRD--------------------
---STAGLESRDPLRGRLVAPEA--------------GSRLQETQ------------KLQ
ES---K-ENAQ-DS-RRKAIW---------GYXXXXXXXXXXXXXXXXXXX---XXX---
XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQRGRKL-QR--HVSD-PTEPATII
LTAAQEGQET-R--CSHHIANAYTSSQKV--SAIQIDGATRSLQDSDTVKLWVDGELSSG
FESGQKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVKSI--EERGCPL
E--------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLRDPPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1006)

RHLE---NVPAVSSQAQ
KTTVPESAT---K-------EA--QSPGSASGLNK-----------GPPGIEELGPGR--
------------------------ADT-G----------------AQS-EGPDDMTDGKH
-PEDGS-----------------KQETNRSSQD--GEQG-HHFH-PGSPGERFL---DQV
PNHSPGDM-VGRAGAHP-------------------------------------------
------------------------------------------------------------
----------------------------GSHSAALPEEGRISTAASQEPPAPDS-QDAQG
SGGPSTGLESQGALRRR----LVAP-E---------PTRHLQAEQ------------RSE
EKEKR-TH---------------GGRRQSYGHIIFVVMGIGLAVFLL-NAI---SSY---
YFSQAQQVHKNPALETFLAHFTQLQDKFPGQSSFLWQRGRKFLQKHLNVSN-PTEPATVI
FTAAREGRET-LKCLSYHVADAYTSSQKV--SAIQIDGAARTWQDSDMVKLLVDLELSSG
FENGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQ--------------
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MEENSSVGLPGAGPAQEEVESTAKHPVHQEPPQ
ESPEHRVTSTWPETSCRPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (320, 1018)

EDSSVCKPPAAHGGEETLTE------LDSPTVE--SPQDTQ
VPQ--------ETELSLEESGETKDDT-S----------------ERP-REEND------
--LDRA---------------------------------------------RLV---QNA
MHCAGHGHGLQEAQED--QETSRQPESSNTAEEDASSRSKSLSSGSEMT-----------
---------------------------RSD------LNA-P-QDVTEGLLA-RE------
-----------------------------STSAPLLEQEA-----------------GEH
IEQVTLQSDSSGTLRSRHGTKGHA-------------APQPEAQH------------CLQ
NI---TAQNTEQEKPKESLLV--------KGL-----VLLGLVFLGFCIFC---FGN---
PTAKSQPAPRNPTVEAFLSQFNQLQDRFPGQSPDLWLRSRKFLQKHLNASR-HTQPAIII
FTAARKGERT-LRCLSTHVADSYSAALRA--STAHIDGEDKSGLQSDQAKLEVDSELSSA
FQAGDCAAVIHRFELLPAGATLIFYKYCDHESAAFKDVALLLTVLLEE-EMLETHIRLQQ
VEERVRDFLWAKFTSASAPSSYDHMDS-DKLSGLWSRISHLVLPIHPVQNI--EKGGCHT
KP-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLG---NDPSVNSQVQ
ETTIIASNA---E-------EA--EILHSACGLSK-----------DHQEVETEGPES--
------------------------ADT-G----------------DKS-ESPDEANVGEH
-PKDKT-----------------EDENKQSFLD--GGKG-HHLP-SENLGKEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QEPPTTDSQEAQ
STG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-K---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPVILVVLV---VAVVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVSSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------SRQR-RQPRLQEA-E

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRATRLQQ----QQYSEPPPLQPSPVTTRRGLRDSHSSE------E---DEPPS-----
------------------------QTVLSPTVSKNT---I-----RRTQT-PXXXXXX--
------------------------XX--X-----X-------------------XXXXXX
XXXXXA----------------TSVQQKINFSE-EGETE------------------END
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VT-
VVVRSGD----SVESGXXXXXX-XXXXXXXXXXXXXXP-DFTAFDKQPL-VLSS-GY---
--QKNPQEWVEKTTRIRTRM----------------QNDGVQKSEL--GNQSPSAS---S
Q-QVTGQPQS-ASFVKV--------------KWWWPLVLIA--GLLIGCF---LYTRT--
-----PEAETT-AVQEFQNQMKQLMNKYQGQDEKLWKRSLTFLEKHLNSSHPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFQSV--PAIRIDGTGKATQDSDVVKQEVDEELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKLKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENDL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDRALRDPPE--DPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINCQAQ
ETTVTASPT---E-------EA--QTPNPASGLNK-----------DHQEVESVGPGS--
------------------------TDT-D----------------DQS-ESPDETDDRKY
-PKDT------------------EGENSQSFQG--GEQG-HPLP-SESLGEDLL---DPE
PNNSPSDK-VGRTDAHLVSSSAALPE--------HVSDRPGAL-----QEPPVLDPQDTQ
SPG-HSSAGLES------------------------------------------------
------------------------------------------------------------
----------QDTLRKR----LPAP-E---------VERHQQETQ------------KLE
GNKE-NVQDTIRKINKK-DFR-------SYGSIFLGFLVLILV-LLS-S-V---SSY---
YSCPAQQVPKNPALEAFLVHFSHLKDKFPGQSSFLWQRGRKFLQKHLNASH-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSAQKV--SAIQIDGAGKTFQDSDKVKESVDKKLSSG
FEKGQKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTILLEE-ETLEASVSPRE
TEEKVRDLLWARFTNSNTPSSFRHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEHGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------W

PF05609 // ENSGT00390000012166_0_Domain_3 (753, 1019)

-TLLVLLIV--ALALC-V---WWTGMLT
MSTTKSSRTTQ-ILQVFRARMDKLKETYQSQDPSLWRKTHMFLEKYLNVSQPHTKPAILL
FTAGREAEKA-LRCLSNEIADAFAFSQNA--TAIKINGADKAEMDSDDVKMEVDNQLSSG
FSKGKKVAVVHRFELLPAGSTLIFYKYCDHENAAFKDVALLLTVLLDE-KSLGKSLTVPE
LEEKVRDFLETKFTSSDVPSSYNSMDT-DKLSGLWSRISHLVLPVRPEEGL--PMEGCTC
STKSF----------------

------------------------------------------------------------
----------------------------MAGEARRTEPVREGWEVYVTPRAPLREGRHRL
AAQNGRG-SGAPAYRTLSPSRHG-RREVRFSEEPPEV--YGDFEPRV-TEERSPV-----
--GR-RTPPKEFRP--------------DSAKEEVRESAYNLRSRQR-RQPLLQEAVE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRATRLQQPHSQQQISQQPLLQRSPVTTRRGLWDSQSS------EE---DESSP-----
------------------------QTVLSQAVSKK---SV-----RRAQE-VP-VVS---
------------------------ED--P-----VVSLCRPPLRSSRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EED
KDGSDSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSRD----STESRDQNTRSASSQYSESLWQLSQSRN-FIAHEKQPS-MLSS-GY---
--QKNPQEWVKQTTRKRTRMQTSSPSK-ISKYGSFSDDDSVQKSQL--GNQSPSTS---S
Q-QVTGQPKN-TSFVKM-K------------W-WWAFLLIA--ALVIGSF---WSIHT--
-----PEIETT-AVQEFQNQMKQLMNKYRGQDEKLWKRSLTFLEKHLNNSHPQPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGADKAAQDSDTVKLEVDRELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLDLKE
IEEKVRDFLRAKFTSSNMPNSYNHMDP-DKLSGLWSRISHLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
----------------------------MAREGRRAEPAGEGWALYVTPRAPLREGRHRL
APQNGSG-SDAPAYGT-SPSRQG-RREVRFSEEPPEV--YGDFEPRV-AKERSPV-----
--GK-RNPPEEFRP--------------DSAKEEVRESAYYLRSRQR-RQPRLQEAEEMK
TRRATRLLQQH-----SPQPPLPPSPVTARRGLRDSQSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DETSY-----
------------------------QTVTSQTVSKK---TV-----RRTQE-AP-AVAS--
------------------------ED--P-----VISLCRPPLRSPRS-DSTYKTNGNTK
MSEVEA----------------ASVLQKVNFSEEEGETE------------------DDD
QDSSYSD-----------------------------------------------------
---------------------------------------------------------ITA
VKVKSGD----SVESRDLTTRSTSGQHPESIWRLSQNQD-FTAQEKQTS-VLSS-GY---
--QKNPQECIEQNVRMRTKMQTSSPGK-SSVYGRFPDDDSIQKSEL--GNQSPSNS---S
Q-QVAEQPQN-ESFVKR-K------------WGWWLLFMIA--PLACGIL---WFLHT--
-----PEVETA-AVQEFQNQMQQLMTKYQGQDEKLWKRSQTFLEKHLNSSHPRNQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAEDSDIVKLEVDQQLSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEERWAEPLTARWGIFATPRAPIREGRRRL
APQ-DGGGSDALTYGTPPAR-QG-RREVRFSEEPPEV--YGDFEPRG-AKERSPA-----
--GR-RTPPEKFRG--------------DSPEEEVKEIVYNLRSRRR-RQRGPQEAEEMK
TRR

PF05609 // ENSGT00390000012166_0_Domain_3 (244, 1019)

AQ-----------SQQPPPQPSPVTTRRGLRDSLSSEG-E-VED---EP-SS-----
------------------------QTVINQTVSKKT---------VRTQE-TS--VVS--
------------------------ED--P-----AVNLCRPPLRSPRSGKRL--------
---------------------------CAVYFL-SGETE-------------------DD
QDSSYSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSRD----SVASKD---------------------QDFTAHDKQPS-VLSS-GC---
--QKNPQEWVEQALRMRSRTANN----------------NVQKSEL--GNQSPSTT---S
S-QPLVR-------RKR-W------------K-WLIPCLLA---LALVIF---WFIHT--
-----PGIETN-AVQEFQNQMRQLRNKYQSQDEKLWKRSETFLEKHLNGSHPRPQPAILL
LTAAQDAEEA-LKCLSERIADAYSSFHSV--PAIRIDGADKADQDSDAVKLEVDEKLSNG
FRNGRNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNPDTPSSHNHMDP-DKLSGLWSRISHLVLPVQPETAL--KSGGCL-
---------------------

------------------------------------------------------------
----------------------------MAGEGQRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLCRPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
PDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSRN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDNIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------C-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDAVKLEVDQELSNG
FKNGQNAAVVHRIESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

PGGGSDPQQLTHRRG--RH-SPPDTPWAQRRLRSTAASTPAAASITVSCLPDRRPQPPTP
RSRSQQQEDP-R--NTKSPPGPTATSTKMADGGWRAESRWEDWGAHVTPRAPLRQGGNRP
GPQHGDSGRNAPAQVTPAPPRPG-RREVRFSEEPPEV--YGDLESPV-SGDRPPG-----
--GK-RSPREEFRH--------------DSEKEEVRENTYYLRSQRR-QPAP-R-VSE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRTALQ------EQQHQEPTLQPSPVTTRRSLRDAQFS------EE---DEPSS-----
------------------------QVILKQTVSKKK---I------RTQD-TS--VVS--
------------------------EV--L-----MSDLRRPPLRSSRSXX----------
----------------------XXXXXXXXXXX-XXEME------------------NDD
QDTSDSE-----------------------------------------------------
---------------------------------------------------------VST
AVVRNRD----SVESGDQTSRS-SSQYQESFWQSSQX-XXXXXXXXXXX-XXXS-GY---
--QKIPQGI--------------------------------VEPTI--R---IRSK---M
Q-KGTEQSKD-ASFLKR-S------------WLWLVVL-FI---FVTCSI---WFIQT--
-----PEAETTAAIEKFQIRMKQLMERYQGQDEKLWKRSLTLLEKHLRSSRPPPQPAILL
LTAARDAEEV-LRCLSEQIADAYSSIHSN--HAIRINGTSKASQDSDTVKHEVDQELNNG
FTNGHKAAVVHRIESLPASSTLIFYKYCDHESAAFKDVALVLTVLLEE-ETLGTSPDLKE
IEEKVRDFLKVKFTKSDTPNSYNQMDS-DKLSGLWSRISHLVLPVQPENAL--KKGICL-
---------------------

------------------------------------------------------------
----------------------------MAREGRRAEPAGAPWGMYVTPRAPLREGRLRC
AAQ-DGGDGDALAYGTPPSR-QG-RREVRFSEEPPEV--YGDFEPQT-AQEGSPV-----
--GR-RTPPGEFRP--------------DSAKEEVRESPYYLRSRQR-RRPRPQEAGEMK
TRREARPERSPN----SLESPLQPSPATTRRGLRDSQSSEG-GNRGK---DESSS-----
------------------------QTVTNQTAL-KT---------VRTQE-AP--VTS--
------------------------ED--P-----ISSLRRPPLRSTRH-ESTYRTHENTE
MS------------------------------E-QGETE------------------EDD
QDGTYSD-----------------------------------------------------
---------------------------------------------------------VTA
GKVRSGD----SV

PF05609 // ENSGT00390000012166_0_Domain_3 (614, 1019)

KSGG---------------------QDSAAQNKQSS-VLSS-GY---
--QKTPQEWSEQNVRMRAKMQSG----------------SILTSEF--GNQPPSPS---N
K-QIAEQPPN-EYFFKR-K------------L-FWCLLFSLVII-IPLVK---FFFPT--
-----PEIETT-AVQMFQNQMKQLRNKYQGQDEKLWDRSLTFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTRKAAQDSDVVKLEVDQELSNG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHETAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPNSYNHMDL-DKLNGLWSRISHLVLPVQPEDAL--KSGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEPEREGWALYVTPRAPLREGRPRL
APQNGGS-SDVPAYGTPTPSRHG-RREVRFSEEPPEV--YGDFEPRA-AKEKARV-----
--GR-QIPLEGFRP--------------DSAKEEVRESAYYLRSRQR-RQPRLHEAEEMQ
TRRSTRLQ----EQLHSPPPPIRPSPVTTRRGLRDSHSSE------E--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1018)

-DEPPS-----
------------------------QTVLSQTVTKKA---I-----RRTQE-TPV--MS--
------------------------ED--P-----LISLCRPPLRSSRS-DSAHKTNGNTK
MSELEA----------------ASVHQKVNYLE-EGETE------------------END
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VT-
VKVRSGD----SVESEDQTTRS-SSQYKESLWQSSQSR-DFTAFDKQPL-MLSS-GY---
--QKTPQERVEQTTRIRTRMQTSSPGK-RSIYGSFSDDDSVQKSEL--GNQSPSTS---N
Q-QMTGQPRS-ASSVKT--------------KWYWPLVVIA--ALLIGSF---WYTHP--
-----PEAETT-AVQEFQNQMKQLMNKYQGQDEKLWKRSQTLLEKHLNGSQPQPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--PAIRIDGAGKAARDSDTVKEEVDQELSTG
FRNGQKAAVVHRFESLPADSTLIFYKYCDHESAAFKDVALVLTVLLEE-ETLGTNLGLKE
IEEKVRDFLKVKFTNSNTPSSYEHMDP-DKLSGLWSRISHLVLPVQPENDL--KRGICF-
---------------------

------------------------------------------------------------
----------------------------MAGERWRAEGLGEGWAIYVTPRAPIREGRRRL
ATQ-NGDGSDAPAYETHPSR-HG-RREVRFSEEPPEV--YGDFEPRA-AKERSPG-----
--ER-RTPPEKFRS--------------DSAKEEVRESAYNLRSRQR-RQRGPQEAEEMK
TRRSTRLEQ--H----SQQAQQQLSPATSGRGLRDAQSLSE-DRGED---E

PF05609 // ENSGT00390000012166_0_Domain_3 (292, 1019)

PS-S-----
------------------------QPVTSQTVSKKT---------VRTPE-TS--VMS--
------------------------ED--P-----ISNLCRPPLRSPRP-D----------
-----A----------------SIV-QHINPFE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------VT-
IRIRSRD----SVESRDEAAVA-AGHHPDSLWGLPHSRGDFTAHENQPS-LLPT-GC---
--QKNPQEWVEQAVRMRTRMAYN----------------NIQKSDF--GNQSPSTS---R
Q-QAAVQPPD-ESSVKI-K------------W-WLLILVAA---LAMGIY---WFFHT--
-----PVVETT-AVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLEKHLNSSLPRPQPAILL
LTAAQDAAEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKHEVDQELTDG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-QTLEASLGLKE
IEEKVRDFLKVKFTSSDTANSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KAGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLRDPPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDPSVNSQEQ
ETTVTASST---E-------EA--QTPNPASGL------------------SKEGPES--
------------------------ADT-G----------------EKS-ERSDETNFGNY
-PKDKT-----------------EDENNLSFQD--GEQK-DHLP-SENLGKEPL---DPD
ANHSPSDK-GRKADANLGSSSASLPE--------EINDRTKPS-----QEPSTADSQEAR
SPS-HSRRE---------------------------------------------------
------------------------------------------------------------
---------SQDSLRRR----WPSP-E---------AGSHEQETQ------------TLG
EKKEI-AQDTIKKIKKK-SFW-------NYGRIIFGSLIVALV-LSS---V---SSY---
YSSPAQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAITINGAERAFQDSDTVKLFVDLELSYG
FEKGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVVLVLTVLLEE-ETLEANVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCFL
---------------------

------------------------------------------------------------
----------------------------MAGEGRAAEALGEGWAADVTPRAPIRAPRRRL
APQ-NGDGSDAPAYGAHPSR-HG-RREVRFSEEPPEV--YGDFEPRV-ARERSPG-----
--GR-RTLPEKFRP--------------DSAKEEVRESAYNLRSRPR-RRRS-RDAEEMK
TRRSARFEQ--P------QPQPQPSPATSRRGFRDSQSSGE-DRRED---EPS-S-----
------------------------QTVTSPTASKKT---------VRTPE-TS--MMS--
------------------------ED--P-----LSNLRRPPLRSPRSSDSTYKTNGNTK
MNEIEA----------------AGI-QQVNFSE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------TT-
VKVRSRD---

PF05609 // ENSGT00390000012166_0_Domain_3 (611, 1019)

-SVESR--------------------G-QDFTAHENQPS-VLSS-GC---
--QRNPQEWVDQVLRMRARLPHN----------------SIQESEL--GHQSPSTS---S
Q-YVAEHAQR-EPSFKT-K------------W-WLLGLVAV---LAIGLF---WFFHT--
-----PVVETT-AVREFQNQMRQLQSKYQSQDEKLWKRGTTFLERHLNSSLPRPQPAILL
LTAAQDAEEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDRVKQEVDQELSDG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLAASLGLKE
IEEKVRDFLKVKFTNSDTASSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KGGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------------TD--
------------------------ED--P-----IISLTRPPLRSRRF-DSAYRTN----
-------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (446, 963)

-ENSEMNE-LGETE-----------------DDDD
QDGSYSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSGD----SVESGG---------------------QDSTAHTKQSS-VLSD------
---------------------------------------SVQVSER--RNQSPSSL---N
K-QVAEQPQN-EYFLKR-K------------W-FWLPVILVLIIFGFVYY---SFIHR--
-----PEEETR-AVQMFQDQMKQLRKKYQGQDEKLWERSLTFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDVVKLEVDQELSSG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHETAAFKDVALILTVLLEE-KTLGTSLGLKE
IEE---------------------------------------------------------
---------------------

------------------------------------------------------------
----------------------------MAGERWQAEGPGEGWAIYVTPRAPIREGRPRL
DPR-NGDSSDAPAYGAHPSR-RR-RREVRFSEEPAEV--YGDFEPRA-AKERSPG-----
--GR-RTPPEKFRP--------------ASAGEEVRESAYNLRSRPR-RQRRAQEAEEMK
TRRSARLEQ--H----SQQ--PQLSPARSSRGLRDSPSSSE-DREED---EPS-S-----
------------------------RPVTSQTASKKT---------LRTPE-AS--VMN--
------------------------ED--P-----ISNLCRPPLRSPRP-DLTYQTNGNTK
TNEREA----------------TTA-QQVNFFE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------VT-
LRARPSD----SLE

PF05609 // ENSGT00390000012166_0_Domain_3 (615, 1019)

SRD---------------------QDFPAHENQPL-LLTS-GC---
--QENPQEWVEQAVRMRNRMAYN----------------NIQKSNF--GNQSPSTS---R
P-QAAIQHPN-EPSVKI-K------------W-WLLGLVAT---LAVGIF---WFFHT--
-----PAVETT-AVQEFQNQMKQLQSKYQSQNEKLWKRGTTFLEKHLNNSLPRPQPAILL
LTAAQDAAEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKHEVDQELTDG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLDE-KTLEASLGLKE
IEEKVRDFLKVKFTSSSTASSYNHMDP-DKLSGLWSRISHLVLPVQPENAL--KAGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MSLDRQDKNMMDSGCSDPVG--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDSSVDSQAQ
GTTVTANDT----------EEV--QTAPPASDLKD-----------DHHEVEAKGQEQ--
------------------------ADT-G----------------DKP-ESSEEMALGKH
-PVDKA-----------------EHQSSPSSQD--TEQG-HHPP-SEHLGGEAL---QLD
PNCSQSSK-GGTAGAHLGSSSTGL------------------------------------
------------------------------------------------------------
-----------------------------------PEGAGDRCEAAQEPLATDS-TDAPS
PVHSSADPGSQDLLRRR----LPVS-E---------AGSPEEETK------------LVK
EKQEAAQD-SLRKTDKK-SLW-------SYGLLFLCCLIVALV---L-SSI---NSY---
YSSLAQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNVSN-PTEPATII
FTAAQEGKET-LKCLSHHVANAYTSSQKV--SAVSIDGAERALQDSDVVKLWVDLELSSG
FKNGNKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALILTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSETPSSFSHMDS-DKLSGLWSRISHLVLPVQPVKNI--EERGCLL
---------------------

------------------------------------------------------------
----------------------------MADEGQREEPEGERWGMYVTARAPLREGRLRP
ASQ-DGGGGDVLAYGTPPSR-QG-RREVRFSEEPPEV--YGDFEPQM-AKERSPV-----
--GK-QTPPEEFQP--------------DSAKEEGRESAYYLRSRQR-RQPRPQSVEEMN
TRRTARLLQP-H----SQQPQLQPSPVTSRRGLRDSLSSEG-EDSGE---DEPSS-----
------------------------QTVTNQTVSKKS---------VRTQE-AP--VTS--
------------------------ED--P-----VISLCRPPLRSTRS-DSAYRTNENTK
MNELET----------------I--PQYIVYFS-LGETE------------------DDD
QDGSYSD-----------------------------------------------------
---------------------------------------------------------TTT
VKVRSGD---

PF05609 // ENSGT00390000012166_0_Domain_3 (611, 1019)

-SVEP------------------------------------GGS-GY---
--QKNPQEWFEHQIRMRTRMQS-----------------NIQMSEL--GNQSPSLS---S
Q-QVAEQPRN-EYFFKK-K------------W-FLCLLVVISVL-VLWNF---SFIHM--
-----PGVETT-AVQMFQNQMKQLRNKYQGQDEKLWERSLMFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDVVKLEVDQELSNG
FTNGQNAAVVHRLESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLGTSLGLKE
IEEKVRDFLKVKFTSSSTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-DGTSSRRD

PF05609 // ENSGT00390000012166_0_Domain_3 (790, 1018)

AE-ILQEFRARMEKLKNTYQSQDPDLWRRARASLEKRLNSSRVHLEPAILL
LTAGREAEKA-LRCLSNEIANAFASSQNA--TTISINGVDKAVQDSDTVKQQVDTELSSG
FSKGKKVAVVHRFESLPAGSTLIFYKYCDHENAAYKDVALLLTVLLDE-QSLRKSLTFQQ
VEEKVRDFLWAKFTSSDVPSSYNDMDT-DKLSGLWSRISHLVLPVWPERGL--PLEGCT-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-SLSRQG-RREVRFSDEPPEV--YGDFEPLV-DKERSPV-----
--GK-RTRLEEFRS--------------DSAKEEVRESAYYLRSRQR-RQPRPQEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRTTRLQQQH-----SQQPPLQPSPVMTRRGLRDSHSS------EE---DEPSS-----
------------------------PTDLSQTISKK---TV-----RSIQE-AP-AES---
------------------------ED--L-----VISLRRPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE-------------------DD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKSRSRD----SDESGDKTTRS-SSQYIESFWQSSQSQN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARMRTRMQTSSPGK-SSIYGSFSDDDSILKSEL--GNQSPSTS---S
Q-QVTGQPQN-ASFVKR-N------------W-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAD

PF05609 // ENSGT00390000012166_0_Domain_3 (271, 1019)

RGLRDSPE--XXXXXXX---XXXXXXXXXX
XXXXXXXXX---X-------XX--XXXXXXXXXXX-----------XXXXXXXXXXXX--
------------------------XXX-X----------------XX--XXXXXXXXXXX
-XXXXX-----------------XXXXXXXXXX--XXXX-XXQLSPESVGEESL---HPE
PSPSPRDK-AGEADAHLGGSSVALPE--------EASDRPGAS-----QEPPAVDPQGAQ
SPG-PSSAELEG------------------------------------------------
------------------------------------------------------------
----------QGTLRRR----LLVP-E---------AESHQEETQ------------KLE
ENKEN-AQDSIRKTDKK-DFW-------CYGFIFLGCLVMTPV-LLS-FAA---HSY---
YSSPTQQVANNPALEAFLAHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SAIQIDGTGRTLQDSDVVKLSVDKLLSSG
FEKGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-DTLEASVGPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVNSQAQ
ETTVIASNA---E-------EA--QILYSACGLSK-----------DHQGVETIGPES--
------------------------ADT-G----------------DKS-ESPDEANVGNH
-PKDKI-----------------EDENKQSFLD--GGKG-HHLP-SENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QEPPTTDYQEAQ
GPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSYPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGRMFLAILV---VAVVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--PPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSHTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------S-SDVPAYGTPTPSRHG-RREVRFSEEPPEV--YGDFEPRA-AKEKARV-----
--GR-QIPLEGFRP--------------DSAKEEVRESAYYLRSRQR-RQPRLHEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1018)

MQ
TRRATRLQ----EQLHSPPPPIRPSPVTTRRGLRDSHSSE------E---DEPPS-----
------------------------QTVLSQTVTNKA---I-----RRTRE-TPVLVMS--
------------------------ED--P-----LISLCRPPLRSSRS-DSAHKTNGNTK
MSELEA----------------ASVHQKVNYLE-EGETE------------------END
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VT-
VKVRSGD----SVESEDQTTRS-SSHYKESLWQSSQSR-DFTAFDKQPL-MLSS-GY---
--QKTAQERVEQTTRIRTRMQTSSPGK-RSIYGSFSDDDSVQKSEL--GNQSPSTS---N
Q-QMTGQPRS-ASSVKT--------------KWYWPLVVIA--ALVIGSF---WYTHP--
-----PEAETT-AVQEFQNQMKQLMNKYQGQDEKLWKRSQTLLEKHLNGSQPRPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--PAIRIDGAGKAARDSDTVKEEVDQELSTG
FRNGQKAAVVHRFESLPADSTLIFYKYCDHESAAFKDVALVLTVLLEE-ETLGTNLGLKE
IEEKVRDFLKVKFTNSDTSSSYKHMDP-DKLSGLWSRISHLVLPVQPENDL--KRGICF-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------HL

PF05609 // ENSGT00390000012166_0_Domain_3 (835, 1018)

EPAILL
LTAGQEAEKA-LRCLSNEIANAFASSQNA--TTISIDGVGKAVLDSDAVKEEVDTELSSG
FSEGKKVAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALLLTVLLDE-QSLRKSLTFQE
VEEKVRDFLWAKFINSDVPSSYNSMDT-DKLSGLWSRISHLVLPVWPEKGL--PLEGCT-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (834, 1018)

TQPAIII
LTAARRGERT-LRCLSARLADSYSAALHG--GTVQIEGRAKARLHSDQAKQEVDSELSSA
FQAGGRAAVVHRFELLPAGATLIFYKYCDHESAAFKDVALLLTVLLEE-DVLESHISLQQ
VEEKVRDFLWAKFTSTSTPSSYDRMDS-DKLSGLWSRISHLVLPIHPVQSI--EEGGCY-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NNPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAGERWQAEGPGEGWAIYVTPRAPIREGRRRL
DPR-NGDSSDAPAYGAHPSR-RG-RREVRFSEEPAEV--YGDFEPRA-AKERSPG-----
--GR-RTPPEKFRP--------------ASAGEEVRESAYNLRSRPR-RQRRAQEAEEMK
TRRSARLEQ--H----SQQ--PQLSPATSGRGLRDSPSSSE-DREED---EPS-S-----
------------------------RPVTSQTASKKT---------LRTPE-AS--VMN--
------------------------ED--P-----ISNLCRPPLRSPRL-DSTYQTNGNTK
TNEREA----------------TIV-QQVNFFE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------IT-
IRARS

PF05609 // ENSGT00390000012166_0_Domain_3 (606, 1019)

SD----SLESRD---------------------QDFPAHENQPL-LLTS-GC---
--QENPQEWVDRAVRMRSRMAYN----------------NIQKSNF--GNQSPSTS---R
P-QSAIHHPN-EPSVKI-K------------W-WLLGLVAI---LAVGLF---WFFHT--
-----PAVETT-AVQEFQNQMKQLQSKYQSQNEKLWKRGTTFLEKHLNSSLPRPQPAILL
LTAAQDAAEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKHEVDQELTDG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLEASLGLKE
IEEKVRDFLKVKFTSSSTASSYNHMDP-DKLNGLWSRISHLVLPVQPENTL--KAGSCL-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAELAREGWGLYVTPRAPLREGRPRL
APQNGGGGDAPA--HGTLPSRQG-RREVRFSEEPPEV--YGDFEPRV-AKERSPA-----
--GR-RVPSEEFRP--------------GSGKEELRESAYYLRSRQR-RPPRPRDAGE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1004)

MK
TRRATRQLQQ---QQHSPQPPAQASPITTRRGLRDSQSS------EE---DEPSS-----
------------------------QTVLSQTDSKKT---V-----RRTQE-IP--VLS--
------------------------ED--P-----VISLCRPPLRSPRSEA----------
----------------------TIIQPKVNFSE-EGETE------------------DDD
QESSFSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVGSRD----SVDSGDHTTRS-SGHHPESFWQSPQS-GDVRARDKQPA-VLSS-GY---
--QKNPQEWGEQTLRMRVGMQNN----------------RIQKSELGFRNQSPVASSQLI
R-NELEEASG-PAREGR-K------------WCCGLLALLA---ALACAA---L------
-----------WLVRQFQAQMQQLKRSYRGQG-RLWRRSQTLLGAAPQRLAPRRQPAILL
LAAARDAEPAPAPALGERIADAYSAFRSV--RAIRIDGAGQAARDSDAVK-EVDRELSEG
FRNGRNAAVVHRFESLPAGATLIFYK-CDHENAAFKDVALVLTVLLEE-ETLGTSPGLKE
VEEKVRDFLRAKFTSSDTPSAYNDMDA-DKLNGLWSRISHLVPARAPPDQTSKLQSSCV-
---------------------

------------------------------------------------------------
----------------------------MADEGQREEPEGERWGMYVTARAPLREGRLRP
ASQ-DGGGGDVLAYGTPPSR-QG-RREVRFSEEPPEV--YGDFEPQM-AKERSPV-----
--GK-QTPPEEFQP--------------DSAKEEGRESAYYLRSRQR-RQPRPQSVEEMN
TRRTARLLQP-H----SQQPQLQPSPVTSRRGLRDSLSSEG-EDSGE---DEPSS-----
------------------------QTVTNQTVSKKS---------VRTQE-AP--VTS--
------------------------ED--P-----VISLCRPPLRSTRS-DSAYRTNENTK
MNELET----------------I--PQYIVYFS-LGETE------------------DDD
QDGSYSD-----------------------------------------------------
---------------------------------------------------------TTT
VKVRSGD---

PF05609 // ENSGT00390000012166_0_Domain_3 (611, 1019)

-SVEP------------------------------------GGS-GY---
--QKNPQEWFEHQIRMRTRMQS-----------------NIQMSEL--GNQSPSLS---S
Q-QVAEQPRN-EYFFKK-K------------W-FLCLLVVISVL-VLWNF---SFIHM--
-----PGVETT-AVQMFQNQMKQLRNKYQGQDEKLWERSLMFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDVVKLEVDQELSNG
FTNGQNAAVVHRLESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLGTSLGLKE
IEEKVRDFLKVKFTSSSTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
MKETG-----------------AT

PF05609 // ENSGT00390000012166_0_Domain_3 (445, 1019)

RMQKVEFSE-EGETE-----------------EEEA
EHHNISD-----------------------------------------------------
---------------------------------------------------------NDV
NPLNHS-DED-STKSRGQEI-----K-L----------------PNKQSPLLTS-QA---
--PIKTQEWSGQNARLRTKSPTSTVD-QNLIHDHFSDDDNVHKSKL--RNKSLLSV---N
Q--NQ--SKK-KS-SVK-V------------W-LLVGLVLSLITSSFF-F---FWTST--
-----PSVETT-AVQKFQNQMKKLMNKYRSQDEKLWKRSQMFLEKHLNSSHPRPQPAILL
LTAAQDAEET-LKCLSEQIADAYSSFHRV--RAIRINGTDKSTQDSDHVKFQVDQKLNDG
FNNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALILTVLLEE-KTLGTDLGLKE
IEEKVRDFLKAKFTSSDTPNSYNHMDS-DKLSGLWSRISHLVLPVQPENSL--KSGVCL-
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEPGREGWGIYVTPRAPLREGRRRL
APQNGGG-SDAPAYGTPSPSRHG-RREVRFSEEPPEV--YGDFEPRA-AKEKSPA-----
--RR-RVPLEEFRP--------------DSAKEEVRESAYYLRSRQR-RQPRRQGAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MN
TRRTVRQ-Q---Q--QSQRPLLQPSPVTTRRGLRDSHSSE------E---DEPPS-----
------------------------QTILSQTVPKKT---I-----QRTPE-IPV--VS--
------------------------ED--P-----IISLRRPPLRSPRS-DSAYKTNGNTK
MSELEA----------------TSIQQKVNFSE-GGETE------------------QDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------ITT
VKVRSGD----SLDSGDQTTRS-STQYPESFWQPSQSR-DFITVDKHPS-VLSS-GY---
--QKKPQECFEQAARIRARTQTSSPGK-SSIYGNFSDDDSIQKSEL--GNQSPSTS---S
Q-QVTGQPKS-ASYSKM--------------WWW-LLVLIV--SLALGSY---LFPHR--
-----PEAETT-AVQEFQNQMKQLMNKYQGQDEKLWKRSLTFLEKHLNSSQPRPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTGKATQDSDVVKQEVDWELSNG
FQNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTSSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGQRAEPEREGWGVYVTPRAPLREGRRRL
APQDGGG-GDAPAYVS-PPSRQG-RREVRFSEEPPEV--YGDFEPRV-TIERSPV-----
--GK-RTPAEEFRP--------------DSAREEVRVSAYYLRSRQR-RQPRPQEAEEMQ
TRRTTRLQQQQ-----SQQPPLQPSPVTTRRGLRDSHSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------QTVFSQTVSEK---TV-----KRTQE-AP-VVN---
------------------------ED--L-----LISLCRPPLRSPRP-E----------
-----S----------------TSVQQKFNYSE-EGETE------------------EDD
QDSSDTD-----------------------------------------------------
---------------------------------------------------------VTT
VKVKSRD----SAESGDQTTRS-SSQYAESFWQSSQIRDN-TAHDKQPS-VLSS-GY---
--EKTSQEWPRQSARLRSRMQLSSPGK-SSLYGSFSDDGSIQKSDL--RNQFSATS---S
Q-QVTGQPRN-ASLVKM-N------------W-WWLLFLIP--LLASVSF---WIFPT--
-----SEVETM-AVQEFQHQMKKLMIKYQGQDEKLWRRSVTLLEKHLNSSHPRPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--PAIRIDGADKAAQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSALIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPNSYDHMDS-DKLNGLWSRISHLVLPVQPENAL--KGGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLRDPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTITASAT---E-------EA--QTPNPASDLNK-----------NHQEVEAVGPGS--
------------------------ADT-C----------------DKS-ESPDETIDGKY
-PKPKT-----------------EPENIRSFPD--GEQG-HLLP--ESLGEEPL---DPE
PNSSPSDK-VGGADAYLGSSSADLPE--------EASDRPGAS-----QEPPASDSQGAQ
GPG-HSTASLES------------------------------------------------
------------------------------------------------------------
----------QSTLRRR----LLVP-E---------AGSHEQETQ------------KLE
ENKKH-AQDIIRKINKK-DFW-------SHGPIFLAFLAMVLIFVLL-GSI---SSY---
YSSQAQQVSKNPALEAFLVQFNQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHYVADAYTSSKKV--SAVHIDGAGRTLQDSDTVKLLVDMELSSG
FGNGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEHGCLL
Y--------------------

------------------------------------------------------------
----------------------------MEGERRRTEGPGEGWAIDVTPRAPIRELRRRL
APQ-NGDSSDAPAYGTHPSR-PG-RREVRFSEEPPEV--YGDFEPRV-AKERSPG-----
--GR-RTPPEKFRP--------------DSAKEEVRESAYNLRSRPR-RRRGPQEA

PF05609 // ENSGT00390000012166_0_Domain_3 (237, 1019)

EEMK
TRRAARVEQ--F----SQQPQPQASPTTSRRGFRDSESSGE-DED------ESSS-----
------------------------QIVTNQTTSKKT---------VRTPE-TS-------
-------------------------S--P-----LSNLCRPPLRSPRS-DSTYKTNGNTR
MNEI-------------------------------GETE-------------------DV
LKSSYSD-----------------------------------------------------
---------------------------------------------------------VT-
VRVKSRN----YAESSG-------------------N-EDFTAHENQPS-VLN-------
----------------------N----------------SIQESEL--GNQSPSTS---S
Q-QAAEQPQN-ESSVNR-K------------L-WLLALFVA---FVSGVL---WLRYP--
-----PAVETT-AVQEFQNQMKQLRSKYQSQDEKLWKRGTTFLERHLNSSLPRLQPAILL
LTAAQDAEEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDEVKQQVDQELSDG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLEASLGLKE
IEEKVRDFLKVKFTSSHTASSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KGGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MAENGD--------------------------Q
ESPQVCPAQEWRRQVMEKTSQAQETENAPRTGQEKVV

PF05609 // ENSGT00390000012166_0_Domain_3 (338, 1018)

EDSGAVQLQASPEIETLGPQETS
CVS--------GSPLTVGEE----LSS-E----------------ERP-VSSDGISLKTY
-PVESP---------------------------------------------GLL---NLT
TRCPPNPMKLPDCSPE--K--------------DAV-----SSLGEKKV-----------
---------------------------HSV------LAA-VEENIPEEPTI-EEESDVTT
LRGELQDPAM---Q------------EPALSSADFLDPTG-----------------ETT
--SNKEGERLQDTVKKRHLTAGAKT-E---------AESHPQETK------------ARQ
GA----------TQKEKSFLG--------NGFAFPASLGILFAVVCFGIYC---NGY---
YTSQPQHVPKNPVVEAFLSGFHQLKDSFPGQSAHLWLRGRKLLQRHLNTSS-PTEPAILI
FTAAREGEET-LKCLSHRIAEVYSTSLHA--STIQIDGAGKARLSSDTAKLEVDRELSAG
FEEGKRAAVVHRFESLPAGSTLIFYKYCDHESAAFKDVALLFTVLLEE-EKLEANIDLLR
AEERVRDFLWARFTNADTPSSYNHMDT-DKLSGLWSRISHLVLPVHPVKAI--ETYGCSL
QAKP-----------------

------------------------------------------------------------
----------------------------MAGEGRRAEPLREDGWLHVTPRAPIREGRRRL
VRQNGGA-DG-DAPAYATASRQG-RREVRFSEEPPEV--YGGDDERRVAQEKSPA-----
--GRRVPSEDSFRL--------------DPEKGELRESAYYLRPRTR-TQPRAQDAGE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MQ
TRRASR-----RLQQLSPQPPPEPSPVTPGRGLRGPRPS------EX---XXXXX-----
------------------------XXXXXXXXXX------------XXXXXXXXXXXS--
------------------------ED--P-----VLSLRRPALRSLRSEASVV-------
-------------------------QPELGFSE-EGESE-----------------DNDQ
DSCFGSD-----------------------------------------------------
---------------------------------------------------------ATT
ESRESVEPEDRTTKSHDQS--------AESSWQLP----------------QSS-GY---
--QKIPQEWDEQTLRMRAGLQNDRNQK----------------TEP--RNHSPLIS---R
H-QATEQAAH-ESYVKM-Q------------W-WWCLLVLIPA-LAYWLS---WLYYT--
-----PEVDTS-AVRQFQDQMKQLKNKYQGQDEKLWKRSQMFLERHLNSSQPRPQPAILL
LTAARDAEAA-LRCLGEQIADAYSAFRSV--RAIRIDGAGRAAQDSDAVKLAVDAQLSHG
FENGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLDSSLGLKE
IEEKVRDFLKVKFTSSNTSSSYSRMDP-DKLNGLWSRISHLVLPVQPETAL--QGGSCL-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGMHVTPRAPIREGRGRL
APQNGGS-SDAPAYAT-PLSRQG-RREVRFSEAPPEV--YGDFEPRA-AKERSPV-----
--GK-RIRLEEFRH--------------DSAKEEVRESAYYLRSRQR-RQPRPQEAEEMK
TRRASRLQQQH-----PEQPPLQPSPATTRRGLRDSHSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------QSDLSQTISKK---TV-----RSTQE-TP-VLS---
------------------------ED--L-----VISLCRPPLRNPRS-DSTYKTNGNTK
MSELEA----------------ISVQQKVIFSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKTRSRD----SDEAGDQTTRS-SSKYTESFWQSSQSRN-FTAHDKQPS-VPSS-GY---
--QKTPQEWSPPTARIRTRMQTSSPGK-SSIYGSFSDDDSIQKSEL--RNQSPSTS---S
R-QVTGQPQN-ASSGKR-S------------W-WWPLALFA--ALTCGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYHGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTGKATQDSDTVKLEVDQELSNG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDRGLRDPPE--DPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDPSLNTQ--
EATVTTSTT---E-------EA--QTPDPAPGLNK-----------DHQEIETVGPGS--
------------------------TDT-D----------------AQS-ENPDETDCGKY
-LKDT------------------EGENSQSFQG--GEQG-HQLP-SESLSEDPV---DPE
TKCSPSDK-VGRTDAHIVGSSAALPE--------HVSDGPGAS-----QEPPVVDPQDAQ
SPG-HSSAGLES------------------------------------------------
------------------------------------------------------------
----------QHTLRRR----LLAP-E---------TETHQQETQ------------ELE
ENKEKNAQGTIRRIDKK-DFL-------SYGSIIFCFLVLIIV-LLS-S-V---NSY---
YSSPAQQVPKNPALEAFLVHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASH-PSEPATII
FTAAREGRET-LKCLSHHVADAYTSAQKV--SAIQIDGAGKTLQDSDKVKHSVDRELSSG
FEKGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVSPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCFV
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------P-V--------

PF05609 // ENSGT00390000012166_0_Domain_3 (696, 1019)

-TESHQQETQ------------ELE
ENKEN-ALATVRKTNKK-DFL-------SYGPIFLGL-VMTIV-LLC-C-V---NSY---
YSSPAQQVPKNPALEAFLAEFSQLRAKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHLVADAYTSSQKV--SAIQIDGAGRTLEDSDTVKHLVDMELSSG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPRSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-PPSRQG-RREVRFSDEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRS--------------DFAKEEVRESAYYLRSRQR-RQPRPQETEEMK
TRRTTRLQQQH-----SEQPPLQPSPVMTRRGLRDSHSS------EE---DEASS-----
------------------------QTDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----VISLRRPPLRYPRS

PF05609 // ENSGT00390000012166_0_Domain_3 (409, 1019)

-E----------
-----T----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKTTRS-SSQYIESFWQSSQSQN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARVRTRMQTSSPGK-SSIYGSFSDDDSILKSEL--GNQSPSTS---S
Q-QVTGQPQN-ASFVKR-N------------R-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEG-RAEPVREEWGLSVTPRAP-REGRGRL
APQNGGG-SDAPAYGTP-PARHG-RREVRFSEAPPEV--YGDFEPRV-AKEKSPV-----
--GR-RVPLEEFRP--------------HSGKEEARESAYYLRSRQR-RQPRPPEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MQ
TRRVARFQQQ----QHSPQPPPHPSPVTTRRGLRDSHSSE------E---DELFS-----
------------------------NTVLSQTGSKKI---I-----QRTQE-TPG--MS--
------------------------DD--P-----VKSLCRPPIRSSGS-D----------
-----A----------------TSVQQKFSFSE-EGETE------------------DDD
QDSYDS------------------------------------------------------
------------------------------------------------------------
VKIRYGD----SVNFGGQTSRS-SSQHSESPWQSAQNR-DFTALDKQPS-VLSS-GY---
--QKTPQQRVEQTTRKRTWM----------------QNDSVQKSEL--WNQSPSTS---N
Q-QVTGQPKN-APFVKT--------------KWWLLLVLIA--ALALGSF---WLSPT--
-----PEVETT-AVQEFQNRMKQLMKKYQGQDEKLWKRSLTFLEKHLNSSQPRPQPAILL
LTAAQDAEQA-LKCLSEQIADAYSSVHSV--RAIRIDGAGKATQDSDAVKLEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLETSLGLKE
IEEKVRDFLKVKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPIQPENAL--KGGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEEQRAEPVREGWGLCVTPRAPLREGRPRL
ALQNGGG-SDAPAYGTPTPSRHG-RREVRFSEEPPEV--YGDFEPRA-AKQKAPG-----
--GR-QIPLEEFRP--------------DSAKEEVRESAYYLRSRQR-RQPRLQEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRATRLQQQQ--QQNSQSSPLQSSPVTTRRGLRDSSRSS-----EE---DEPPS-----
------------------------QTVLSQTVSKKT---I-----RRTQE-TPV--VS--
------------------------ED--P-----IISLCRPPLRGSRS-E----------
-----A----------------TSVQEKVNFSE-EGETE------------------END
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VST
VKVRSRD----SVESEDQTIRS-SSQYPESLWQSSQSR-NYTAFDKQPL-VLSS-GY---
--HKTPQEWIEHATRIRTRM----------------KNDTVLKSDL--GNHSPSTT---S
Q-HMTGQHKS-ASFVQM--------------KWWWPLVLIA--ALVIGSF---WFTPP--
-----MTQTPA-XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXNSSQPRPHPVV-G
LTAARDAEEA-LKSRSEQIADAYSSFRSV--PAIRIDGARKATQDSDIVKREVDQELTNG
FTNGQSAAVVHRF-SLPAGSALIFYNYCDHENASFKDVTLFLTVLLEE-ETLETILGLKE
IEEKVRDFLKVKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENDL--KSGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADDGLTETQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINPQAQ
ETTIIASTP---E-------EA--QTLHSAADLSK-----------GHQEVETIGPES--
------------------------VDT-G----------------DKS-ESPDEANVGKH
-PKDQI-----------------EHENNRSFLD--GEKG-HHLP-SESLSEEPL---DPD
PSRSPSGK-LGQADTRLGSSSAAPPT--------EVSDGMGTS-----QEPRAADSQEAQ
SPG-HSSAGQGG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-ARDIMKKTNKK-NIW-------NYGPVFLCLLVGA---VVL-PSV---YSY---
YFSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGQKFLQKHLNASN-PTEPATVI
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSSG
FENGQKAAVVHNFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWSKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLREPQE--NSQKY

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1019)

SE---NDPSINSQAQ
ETTITASTI---E-------EA--QTPHPASGLNK-----------EHQGIETINPES--
------------------------ADT-V----------------DES-ESPDETNFGDS
-PKEKT-----------------EHENNQSFQD--RKQG-HHVP-SENLCEEPL---DPD
PDHSASDK-EGRADVHLESSSAALPE--------EVSDRTGAS-----QEPSAAVIQEAQ
SPG-HSRVGLES------------------------------------------------
------------------------------------------------------------
----------QDTLRRR----L-PP-E---------AENRQQETQ------------KSE
EKKEN-AQEAIIKISKK-AFW-------SYGPIFVGFLVVAFV-L---NSV---NSY---
YSFPAQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNATN-PTEPATII
FTAAQEGKET-LKCLSHHVADAYTYSQKV--SAIQIDGAGRTLQDSDTVKLLVDMELSYG
FENGQKAAVVHNFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNADTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCLF
KS-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MSQSLKSQNTNMSDSGCRDPVG--DSQNV

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1019)

LE---NDPSINSQTQ
DTRVTPNNT--A--------EA--QPLQPTSDLKE-----------DHHEIGARAQEH--
------------------------TDT-G----------------DRS-ESPEEPALEKP
-PLDKA-----------------ELESSPSSQD--TELG-HHPH-SEHGGGDAL---DLD
PNCSQSDL-GGRADAHLESSSVASPE----------------------------------
------------------------------------------------------------
-------GAG---DRGE------ADEHLESSSAAPTEGAGDRGEAGQELLAEDS-TDGQS
LGHSNTGPGNQDSLRRR----LPVP-E---------AGSHEEETE------------LVK
EKQEVAQD-TLRKTDKK-SLW-------TYGSVFLGCLIVAVV---L-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFGQLKEKFPGQSSFLWQRGRKFLQKHLNASN-PSEPATII
FTAAREGKET-LKCLSYHVANAYTSSQKV--TAVSIDGAERALQDSDTVKLLVDLELSDG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVSPRE
IEEKVRDLLWAKFTNSESPTSYSHMDS-DKLSGLWSRISHLVLPVQPVRNI--EERGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MHAGERAPGS------PSEGGEE
--GRLF--------------------------GHV-------------------------
-------------------------------TPRRPLRERASQNGSG------SNNSSTS
NFRFRTS------------------TPHYPRGRQRQKREVR--FSEEVLELSAEGPFATP
FGKRARMKPRQEREEGLQEEGEEQEDDAPAYRLRSSRLRYPPSPYRRV-EEEDEAQEEQR
LHEEDQ-----------------EEEEG-GSSE--GEEGCHHEPSLTKVQRKPV------
--KKPSNG----------QTQTESPN------------IFGIADDSKLVRPAIR-----R
SPRTGRNVVLGGRGALRRRRGGRPISLS--------------------------------
--------------------------PPPSIWAHVLLWGFS---------------YGQV
KDSTVNKPGSLHSVQK--------------------SPDHYQKTD------------LRA
KI----QPPILKKLPQK-VPK---SSTQSDGVY-S

PF05609 // ENSGT00390000012166_0_Domain_3 (756, 935)

LFMI--LILLVACIAAGGWYAF---
QYTPPHTLESDKALQAFQNQMKELMNNYPSQDKQVWKRIQTAFEKRLNFSQPHLEPAILL
LTAAKEAENS-LKCLSNQIADAFSSSLSA--ATIRIDGARKATLDSDTVKFSVDEMLSSG
FQGGKKAAVVHRFELLPAGSTLIFYKYCDHEHAAFPTWSCLCGLKIFS---LRRNACR--
------------------------------------------------------------
---------------------

------------------------------------------------------------
----------------------------MAREGRRAEPARELWALSATPPPPAAGGTAPP
GFARWAAGADAPAYGSSLRHARA-GGEGRFSEEPARG--VRGFQTPG-G-----------
-------------------------------QKEGSYTIFWIL-----------------
--------------------------------------THH-TFSLE---DEPSS-----
------------------------PTVKNQTLSKKT---------VRTQE-AP--VTD--
------------------------ED--P-----IISLTRPPLRSRRF-GKRLFCLLRLY
S-------------------------SILYYFF-LGETE-----------------DDDD
QDGSYSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSGD----SV

PF05609 // ENSGT00390000012166_0_Domain_3 (614, 1019)

ESGG---------------------QDSTAHTKQSS-VLSS-GY---
--QKNPQEWFEQPVRMRTRMQS-----------------NVQVSER--RNQSPSSL---N
K-QVAEQPQN-EYFLKR-K------------W-FWLPVILVLIIFGFVYY---SFIHR--
-----PEEETR-AVQMFQDQMKQLRKKYQGQDEKLWERSLTFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDVVKLEVDQELSSG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHETAAFKDVALILTVLLEE-KTLGTSLGLKE
IEEKVRDFLKVKFTNSNTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--QRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (834, 1019)

TQPATII
LTAARQGERT-LRCLSTHVADAYSAALHA--STVQIDGRDMSELQSDEAKLQVDSELSSA
FQAGYHAAVVHRFELLPAGSTLIFYKYCDHESAAFKDVALLLTVLLEQ-EELETQISLSR
VEERVRDFLWAKFTGARTPSSYDHVDS-DKLSGLWSRISHLVLPIHPVQNI--EKGGCH-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGMYVTPRAPIREGRGRL
APQNGGS-SDAPAYAT-SLSRQG-RREVRFSEEPPEV--YGDFEPRV-AKERSPV-----
--GK-RIRLEEFRP--------------DSAKEEVRESAYYLRSRQR-RQPRSQEAEEMK
TRRATRVQQQH-----SEQSPLQPSPATTRRGLRDSHSS------EE---DESSS-----
------------------------QSDLSQTISKK---TV-----RSTQE-AP-VLS---
------------------------ED--L-----IISLCRPPLRNPRF------------
----

PF05609 // ENSGT00390000012166_0_Domain_3 (425, 1019)

EA----------------TSVQQKVIFSE-EGETE------------------EED
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKTRSRD----SEESGDQTTRS-SSKYTESFWQSSQSRN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPHTARIRTRMQTSSPGK-SSIYGSSSDDDSIQKSEL--GNQSPSTS---R
R-QLTGQPQN-ASSGRR-N------------W-WGPLALLA--ALACGSF---WFFHT--
-----PEVKTT-AVQEFQNQMNQLKNKYHGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFHSV--RAIRINGTGKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNANTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDDGYRNPPQEYQMK

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

ENLE---KDPTMIPQAQ
ETTVVSSAI---K-------ET--QAGCPISGLKD----------VM--VVETIGSQTLD
AENK-------------------SADV-G----------------GT--DETDEGFPSSS
-PEMEP-----------------EQEKSQDDPS--GKQG-YPYS-SEGSCERPL---DKN
TDSSVT---EGKSNPPPGNSSAVLRE------DNEKSSTPQD------------------
------------------------------------------------------------
-----------------------------------------------------T-METQS
SVLTKEALESDVVVRKR----VRVQ-E---------VKSHHQEPV---------ETCAPE
ESKER-THD-VGKNLEK-NLW-------SLSAIFISVVFI--------ISW---CGS---
FSSQAQQVPKNPALEAFLDQFSQLKDKFPGQTSYLWQRGRKFLQKHLNASS-PTEPATII
FTAAQEGKET-LKCLSHHIADAYTFSQNV--TAIRIDGAQRTSEDSDTIKLLVDVELSTG
FEVGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLDTSVGPRE
TEEKVRDLLWGRFTNSDTPNSFNHMDS-DKLSGLWSRISHLVLPVQPVKKI--EEKGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLSDPQK--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSKEQ
ETTVTASAT---E-------EV--QTPHSAFGLNK-----------DQQEVEKTGPEG--
------------------------ADT-G----------------NKS-ESSDETNLGKY
-PKDKT-----------------EDENNQSFQA--EEQG-HHLP-SESQGEEPV---DPD
PNHPPSDK-VGREDAHIGSSSAALPE------EVS-DRTEEAS-----QEPPAIDSQEVQ
SPG-HSSTGPES------------------------------------------------
------------------------------------------------------------
----------QDALRRR----LLVP-E---------AGSHQQETH------------KLE
ENKENEAQDPIRKINIK-RFW-------NYGPIFLGLLVVAF--VLS-S-V---NSY---
YSSPAHQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSYHVADAYTSSQKV--SAIQIDGTGRTLQDSDTVKLLVDMELSYG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------EPQGLKRENTTMADRGPGDPPK--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTVTASTT---K-------EA--QILSPASGLNK-----------DHQEVETIGSGS--
------------------------ADT-S----------------NQS-ESPDEASYGNY
-PKDKT-----------------ELKTNQSFQD--GKLG-HQLSSKKSGGEESL---HPE
PSCCPSEE-VGRADAQLGSSSVDLPE--------EASNRPEAS-----QKPLAVDPQGVR
GPD-HSSAGPES------------------------------------------------
------------------------------------------------------------
----------QGTRRRR----LVEP-G---------EGSHQQEIQ------------TLE
ENKED-AQDAIRKSNKK-DFW-------SYGSIFLGFLVA-LV-LLS-S-A---QSY---
YSSPAQQVPQNPALEAFLAQFSQLKDTFPGQSAFLWQRGRKFLQKHLNASH-PTEPATII
FTAAREGRET-LRCLSHRVADAYTSSQKV--SAIQIDGAGRTLQDSDTVKLLVDMELSSG
FEDGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-DTLAASVGPRE
TEEKVRDLLWARFTNADTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRAI--EEQGCRL
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PPSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGEAE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSRN-FTAYDKQPS-VLSS-GY---
--QRTLEEWAPQTTRIRTRMQTSSPGK-SSIYGSFSRDDSIQKSEL--GNQSPSTS---S
Q-QVTGQPQN-ASFVKR-N------------C-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRIESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NNPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENKQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

----------MNFRGFFKGELGSSDVWQRD-----------------------------A
RLRVREQRECALTAPA----------ASCPGAGRR------------------RGVRGRC
RLQGGGAGAYQSQHSAGACPPLGGRRHVGWDGDDVLFCRVGGVQPGV-GEQKGPSKGSPD
VDSRRFKAPLEFSPYICFVSWVPEKHEPGGAWDKKKTRH--L-----------REKPD--
TKRK------------GSQRLKRQSANMTDTGLRDLPE--DPQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDSPINTQAQ
DTTVPARTT---E-------EA--QTPDPASGLNQ-----------DHQEIESLGPGS--
------------------------TDA-D----------------DQS-ESPAETNYGKY
-PKDA------------------ESENSPSLPD--GEQG-HQFP-PESPAEDSLDPEPPE
PNCSPSDM-VERTDAPLVSSSAALPE--------DIGSRPQAS-----QEPPVVDLQDAP
CPG-HSSARLDTP-----------------------------------------------
------------------------------------------------------------
---------SQDTLRKR----LLAP-E---------AERHQQETQ------------KLE
ENKEN-AQDTIRKINKK-DFL-------SYGSIFLGFLVLTLV-LLS-S-V---HSY---
YSSPAQQVPPNPALEAFLVHFSQLKAKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATLI
FTAAREGKET-LKCLSHHVADAYTAFQKV--SAIQIDGAGRTWQDSDAVKQSVDLELSSA
FEKGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWERFTNAHTPRSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEHGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MMDSGLPDPPE--ETQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KNLE---NDPSVNSEEQ
ETTVTANSS---E-------ES--QTPSPASDLK------------DHQELQAEGSES--
------------------------TDI-G----------------EKS-ESSSETDFGNC
-SKDKT-----------------ENENNLSFQD--GKQK-DHLP-SENLGKEPL---DPD
ANHSPSAK-GGRANANFGSCSTSLPE--------EVNDRTEAS-----QEPSTTDSQEAR
APS-HSRAE---------------------------------------------------
------------------------------------------------------------
---------SQDLLRKR----LPSP-E---------AESHEQETR------------TLG
ENKEI-AQDTIKKVKKK-SFW-------NYGPMFIGFLVVAFV-LSS---V---SSY---
YSSPAQQVPPNPALEAFLVQFRQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAITINGAERALQDSDTVKLFVDLELSYG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEANVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVNSQAQ
ETTIIASNA---E-------EA--EILHSACGLSK-----------DHQEVETEGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKY
-PKDKT-----------------EDENKQSFLD--GGKG-HHLP-SENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPVILVVLV---VAVVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVSSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEPGREGWVMYVTPRAPLREGRRRL
APQNGGG-SDAPAYGTPSPSRHG-RREVRFSEEPPEV--YGDFEPRV-AKEKSPA-----
--RR-RVPLEEFRP--------------DSGKEEVRESAYYLRSRQR-RQPRLQGAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MH
TRRSIRLQQ---QQPQPQQPLLQPSPVTARRGLRDSPSSEG-EAAGE---DEPSS-----
------------------------QTILSQTIPKKT---I-----QRAQE-TPVLVVS--
------------------------ED--P-----IISLCRPPLRSSRS------------
----EA----------------TGVQQKVNFSE-GGETE------------------QDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------ITT
AKVRSGD----SLDFGDQTTRS-SSQYPESFWQSSQSR-DFITLDKQPS-VLSS-GY---
--QKTPQEWFEQPTRRRARI----------------HNDNIQKTEL--GNWSPSTS---S
Q-QVTGQPKS-ASFIKT--------------WWW-LPVLIV--SLAVGSF---LFTPS--
-----PEVGTT-AVQEFQNQMRQLMNKYQGQDEKLWKRSLTFLEKHLNSSQPRPQPAILL
LTAARDAEEV-LRCLSEQIADAYSSFRSV--RAIRIDGAGKATQDSDVVKQEVDWELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIIASNA---K-------EA--QILHSACGLSK-----------DHQGIETIGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENKQSFLD--GGKG-HHLP-SENVGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QESPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINEK-SFW-------SHGPIFLFFLVVAVVAVVA-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFSRLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVKSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------M

PF05609 // ENSGT00390000012166_0_Domain_3 (822, 1019)

FLVKRLNTTQPHLQPAILL
LTAAQEAEKS-LSCLSNQIAEAYSSSLSA--ATIKIDGAGKAKMNSDTVKLEVDNELSSG
FQEGKKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALLLTVLLDD-KSLAKSLSLRE
VEEKVRDFLQEKFTNSDTPSSYNHMDI-DKLSGLWSRISHLVLPVWPENAL--PKEGCLQ
MN-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADRGLRDPAE--APQKDLK---NDVSVSPQAQ
ETTVPESTI---E-------EA--QTPDSASGLND----------VVHQGVETIGTGS--
------------------------ADT-D----------------DQS-DSPDGTNYGNY
-PKAKT-----------------

PF05609 // ENSGT00390000012166_0_Domain_3 (444, 1018)

QHENNQSFQE--EQNL-------------------PE
PTRSPSDR-VEREDAVLQSGSAALPE--------EVSSEPGVS-----PEPPAADPRGAP
SPE-HSPVAPES------------------------------------------------
------------------------------------------------------------
----------QPSVRRR----RLAP-E---------AESHQQETQ------------ELE
ENKEN-APDTIKKMDKK-DLW-------SYGSIFLCFMVMTIV-LVS-F-V---NSY---
CSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATVI
FTAAQEGRET-LKCLSHLVADAYTSFQKV--SAIQIDGAGRTLEDSDTVKQLVDMELSSG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSDTPRSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCFF
IS-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------SQDTNMADSGCRDPVE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NEPSVNSQGQ
GNTVSPSDP---E-------ET--QTLPPASDLKS-----------DPHEVGAKGQEH--
------------------------ADT-G----------------DRS-ESSEETTSDKR
-SMDKA-----------------EPKSSPSSQD--TEQG-HRPP-SEHLGGEAL---HLD
PHCSQSSE-AERGDAQLGGSSAAAPK------GA--GDGREAA-----QEPLASSAYPSA
--------GPGSQGHVRRRQPMPGET----------------------------------
------------------------------------------------------------
----------SELLSPR----LCFP------------GTPEEEMQ------------SVR
EKE-EAAQERLRKTDSR-SLW-------SYGPMFLGLLIVALV-L---HSV---NSY---
YFSPVQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATVI
FTAAREGRET-LKCLSHHVANAYTSSQKV--SAVSIDGAERALQDSDTIKLWVDLELSNG
FENGHKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLAASVGPRE
TEEKVRDLLWAKFTNSETPSSFSHMDS-DKLSGLWSRISHLVLPVQPVKNI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------YL--

PF05609 // ENSGT00390000012166_0_Domain_3 (774, 1019)

-HGFG--
----SMPSSDSTPVMTFLKEFEKLKAEFPGQNEALWLRSRKMLQKHLNKSH-PLEPATLI
LTAAQDGEHT-LRCLSIGLARAYATSLNS--SWNMIEGPSKAAYDSTTTKLQVDESLSSG
FESTCRAAVLHRIEDLPPASLLILYKYCDHENAVFKNVALVLTVLLKQ-STLKSDHTLTE
VEEQVKDFLWEKCTSRDSGNSYNEMNA-DKMSGVWSRISHLVLPVFPVDSL--ESGSCPW
ICDRNS---------------

------------------------------------------------------------
------------------------------------------------------------
------G-SDAPAYGTPSPSRHG-RREVRFSEEPPEV--YGDFEPPV-AKEKSPG-----
--RR-RLSLEEFRP--------------ESAKGEVRGSAYYLRSRQR-RHPRLQGAEEMN
TRTGEQ

PF05609 // ENSGT00390000012166_0_Domain_3 (247, 1018)

QQ-------QQQHPMLLPKPLPFPLTLR------G-HESPE---DEPST-----
------------------------QTILSQAVPKKT---I-----QRIQE-TPVLVVS--
------------------------ED--P-----VISLCRPPLRSPRS-DSAYKTNGNTK
MSELEA----------------TSVQQKVNFSE-GGETE------------------QDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------ITT
NKVRSGD----SLDSADQTTIL-SSQYPES-WQSSQSR-NFKTFDKQTS-VLSS-AY---
--PKKTQEWFEPTTRIRTTTQTSSPGK-SPKHGSFSDDDSIQKSEL--GNRSPSTS---S
QPEVTGQPKS-ASFIKI--------------KWWWLAVLIA--AFVLGSF---LFTPT--
-----PEVETT-AVQEFQNQMRQLMNKYQGQDEKLWRRSLTFLEKHLNSSQPRPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGAGKATQDSDIVKQEVDWELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-DTLGTSLGLKE
IEEKVRDFLKVKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENAL--KSGIC--
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MSQSLKSQNTDMSDSGCRDPVG--GKP-----------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-VGEGAGD-RGEADAHLESSSAAPPE----------------------------------
------------------------------------------------------------
-------G

PF05609 // ENSGT00390000012166_0_Domain_3 (609, 1019)

AG---DRGK------ADEHLESSSAAPPEGAGDRGEAGQELLAVDS-TDGQS
LGHSNAGPGSQDSLRRR----LPVP-E---------AGSHEEETE------------LVE
EKQEVAQD-TLGKTDKK-SLW-------TYGSVFLGCLIVAVV---L-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFGQLKEKFPGQSSFLWLRGRKFLQKHLNASS-PREPATVI
FTAAREGKET-LKCLSYHVANAYTSSQKV--TAVSIDGAERALQDSDTVKLLVDLELSNG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVSPRE
IEEKVRDLLWAKFTNSESPTSYSHMDS-DKLSGLWSRISHLVLPVQPVRNI--EERGCLL
---------------------

------------------------------------------------------------
----------------------------MAREERRAEPAGARWGLYATPRAPLREGRLRG
APQ-DGGADDALAYGTPPSR-QG-RREVRFSEEPPEV--YGDFEPPT-AKERSLL-----
--GR-RTPPEEFRP--------------ESAKQEARESAYYLRSRQR-RRPRPAEAEEMK
TRRDARLEQQQN----SQERPLQPSPVTTRRRLRDSVSSE------E--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------HTVTNQTVSKKT---------DRTQE-AP-AVTS--
------------------------ED--P-----VISLRRPPLRSTRR-DSAHRTNENTE
MNELET----------------SNVKQKVNFSE-EGETE------------------DDD
QDGSYSD-----------------------------------------------------
---------------------------------------------------------VAT
VKVRSRD----SVESRDQATIL-SGQCPESVWRLPQR-QDSTAHNKQPS-VLSS-GY---
--QKNRQEWFEQHTRMRNRMQTSSPVK-SSIYGHFADGGSIQMSEL--GNQLLSPS---S
K-QVSELPQN-EYFFKR-K------------W-FWCLLSLII-L-AIGTF---FFFRT--
-----PEVETT-AVQMFQNQMKQLRNKYQGQDEKLWERSLTFLQKHLNSSHPRPQPAILL
LTAAQDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDAVKLEVDQELSNG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHETAVFKDVALVLTVLLEE-KTLGTSLGLKE
IEEKVRDFLKVKFTNSNTPSSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDSGLRDPPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1018)

KDLE---NDPSVNSQEQ
ETTVTASST---E-------EA--QTPNPASGL------------------SKEGPES--
------------------------ADT-G----------------EKS-ERSDETNFGNY
-PKDKT-----------------EDENNLSFQD--GEQK-DHLP-SENLGKEPL---DPD
ANHSPSDK-GRKADANLGSSSASLPE--------EINDRTKPS-----QEPSTADSQEAR
SPS-HSRRE---------------------------------------------------
------------------------------------------------------------
---------SQDSLRRR----WPSP-E---------AGSHEQETQ------------TLG
EKKEI-AQDTIKKIKKK-SFW-------NYGRIIFGSLIVALV-LSS---V---SSY---
YSSPAQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAITINGAERAFQDSDTVKLFVDLELSYG
FEKGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVVLVLTVLLEE-ETLEANVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSALGDPPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

EDLE---NGPPVSLPVQ
GTAVTAGVT---E-------GA--QTPPSSPHLAA-----------DHQEVERESPPG--
------------------------VAA-A----------------ESS-AGLGQTGLLEH
-PEGKG-----------------EDETKPRCQD--GERG-HGLP-AGKLGEEPS---DLD
ANTCLSAP-AGGAGEHLMGGSATLPE------EV--SAGTGAA-----------------
------------------------------------------------------------
----------------------------------------------VASPAGAL-HEVQA
PGQPSAGLDSRDPLRRR----QPAP-G---------TGSHEQETQ------------TLE
VKEN--MQDTIRKM--K-DSW-------SYGGALLSCLAVLVV---L-STV---HSY---
YSSPA-QVPRNPALEAFLAQFSQLKEKFPGQSSFVWQRGRKFLQKHLNSSD-PSEPATII
FTAARDGRET-LRCLSYHVADAYTSSHRG--SVIQLDGAQRSSQDSDTVKLWVDLELSSG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLAASVSPRE
AEEKVRDLVWAKFTSSDTPSSFSHVDS-DQLSGLWSRISHLVLPVQPVRGI--EEQGCLV
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NNPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (291, 1019)

DEPSP-----
------------------------HTVLSPTVSKKK--TV-----RRTQE-VS-VVC---
------------------------ED--P-----VISLCRPPLRSPRS-A----------
-----A----------------TSVQQKVNFSE-EGETE------------------EED
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VTT
VKVRSGD----SIESKDQNTRSISSKYPESLWQSSQTLD-FRAHDKQPSV--LS-SY---
--QKNPRELVEQXXX----------------XXXXXXXDSVQKSEL--GNQFPSTS---S
Q-QVAKQPKN-TSYVKM-K------------W-WWSLLLIA--ALVIGSF---WSIDT--
-----PEVYST-AVQEFHNQLKHLMNKYQGQNDNLWIRSLTFLEKHLNNSPMW-WIPILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGTDKAAQDSDTVKHEVDQELSNG
FKNGQNATVVHRFESLPASSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLRAKFIDSNTPSSYDHMDP-DKLSGLWSRISYLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------MENCLLLAL--------QGLSFHGILGVL

PF05609 // ENSGT00390000012166_0_Domain_3 (762, 1018)

-VFLVAVFIS---SGY---
YTSRPAVVPKNPAVEAFLSRFDPLKDSFPDQSPYLWGRVRKVLQKHLNVSH-HTEPAILI
FTAAQEGEAT-LKCLSVQIADAYSSSLQG--STILVDGASKSTLNSDRAKLAVDEELSLG
FHGGGKAAVVHQFESLPAGSTLIFYKYCDHESAAFKDVALILTVLLED-EKLEPDVGLQI
VEEHVRDFLWAKFTKSDMPSSYNHMDT-DKLSGLWSRISHLVLPVHPVQTL--EDRGCSL
QTRPRGDSGERPEKA------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (801, 848)

MKQQINNYQGQDEK----NLTFLEKHLNSAQPWLHPSILL
LTADQDA

ENSGT00390000012166_0_Linker_3_4 (848, 876)

E--------------------------G

PF05609 // ENSGT00390000012166_0_Domain_4 (876, 1003)

IDGAGKATEDSDIVKQEVGQEL---
-------IVVLYFESLPAGSTLIFFKYCDHESAAFKDVALVLIVLLE--ETLGTNLGLKE
TEEKVRDFLKVKFSNSDTPNSYKHICCCSNANGLWSSISHLVLEYLLIRED--RKSSSSE
NFSNFLTRNRIQSFFLKELVF

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDNGYVNPQEG--MFKN

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1018)

LE---KDPTVTPQTL
EAIKASEVT---E-------ET--QIQCPVSGLKD-----------TPIEAETIGSQS--
------------------------LDA-E----------------NKS-ASTCEIDEGNS
-PETEQ-----------------EKEESQNDSI--SKQG-YSHN-TEGLCERPV---DQN
ISISLKEK-ESPTP-LQEKSSAVLTE------DNEKSTIP--------QKPNAD------
--------------------------------------------------------EKVP
---------D---AVG-----------------------------------------TQN
SVTAKEELENQVMVRKLICCMLLLFPE---------VRSHQQESV---------ETRRPE
ENKER-AQ-DVGKSPEK-TLWSK-------LGHTIGFLAVLIFV----VAF---ISS---
FSSQAQQVPKNPALEAFLDQFSQLKDKFPGQSSYLWQRGRKFLQKHLNASS-PVEPATII
FTAAQEGKET-LKCLSHHIADAYTFFQNV--SAIKIDGAHRTSQDSDTVKLLVDIELSTG
FEVGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEKSVGPRE
TEEKVRDLLWARFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVEKI--EEKGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------MT-----------
---------------------------HLD-----

PF05609 // ENSGT00390000012166_0_Domain_3 (576, 1018)

-VTG-V-EDVPSGLLA-EK------
-----------------------------SSSATLPDWKP-----------------EAP
REQETQERGSQGTLRK--RPKGET-------------TPNPETQS------------SLQ
NI---TTENTEQEKPKKSLPW--------KGL-----FIVGLAVLGFCIFC---FGS---
PTSSSQQPRRNPAVEAFLSQLEQLQRSFPGQSPELWLRGRKLLRKHLNASR-PAQPATII
LTAARGARRT-LRCLSARLADCYSAALHG--STVHIDGGDKAGLHSDRAKLELDSELSAA
FGAGGRAAVIHRFELLPAGATLIFYKYCDHENAAFKDVALLLTVLLEE-EALESRISLQQ
VEERVRDFLWAKFTSSGAPSSYNDMDS-DKLSGLWSRISHLVLPIHPVQSI--EEEGCYA
KP-------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------NTNMTDSGLRDPPE--DFQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDQSINSQAQ
ETTVTASAS---E-------EA--QIPNPASDLNK-----------DHQEVETGSPGS--
------------------------ADT-C----------------DKS-GSPDETVDGKY
-PKDKT-----------------EHENIRSFPG--GEQG-HLLP--ESTGEEPL---DPD
PNCSPSDK-VEGADAYLGSSYGDICE--------EVSGRTEAS-----QEPPAPDSQDAQ
GPG-HSTAGLGS------------------------------------------------
------------------------------------------------------------
----------QDILRRR----LLAS-E---------AGSHQQETK------------KLE
ENKES-AQD-IRKINKK-DFQ-------SYGSIFLAFLAMVLIFVLL-GSI---SSY---
YSSQAHQVTKNPALEAFLVHFNQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHYVADAYTSSQKV--SAIHIDGAGRTLQDSDTVKLLVDLELSSG
FENGRKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEWGCLL
---------------------

------------------------------------------------------------
----------------------------MAGEGRRPEAVREGLGMYVTPRAPIREGRGRL
APQNGGS-SDAPAYAT-PLSRQG-RREVRFSEEPPEV--YGDFEPRV-AKERSPV-----
--GK-RIRLVEFRP--------------DSAKEEVRESAYYLRSRQR-RQPLPQEAEEMK
TRRATRLRQQH-----SEQSPLQPSPATARRGLRDSHSS------EE---DELSS-----
------------------------QSDLSQTIS

PF05609 // ENSGT00390000012166_0_Domain_3 (334, 1019)

KK---TV-----RTTQE-AP-VLSE--
------------------------ED--L-----VISLCRPPLRNPRS-E----------
-----A----------------TSVQQKVIFSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTV
VKTRSRD----SDKSGDQTTRS-SSKYTESFWQSSQSQN-FTAHDKQSS-VLSS-GY---
--QKTPQEWAPHTARIRTRMQTSSPGK-SSISGSFSDDDSIQKSEL--RNQSPSTS---S
R-QVTGQPQN-ASSGKR-N------------W-WWLLALVA--AFVYGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYHGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFLSV--RAIRIDGTGKATQDSDTVKLEVDQELSNG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMNP-DQLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-SLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRHPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSHN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDSIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------C-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFHSV--RAIRIDGTDKAAQDSDTVKLEVDQELSNG
FKNGQNAAVVHRIESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADRGLRDPAE--ASQE

PF05609 // ENSGT00390000012166_0_Domain_3 (285, 1019)

DLK---NDPSVSSQAQ
ETIVTASTT---E-------EA--QTPDPVCGLNK-----------VHQEVENIGPGS--
------------------------ADA-G----------------DQS-EDSDETNYGNY
-PKDKT-----------------EHENNQSFQD--EEQG-HQLPDSESPGEKPL---DPE
PSCSPSDK-VGRDDVLLQSDSAALPE--------EVSSGPGVA-----QEPPAVDPQDAP
SPD-RSHAGPEN------------------------------------------------
------------------------------------------------------------
----------QSTVRRR----LLAPAE---------AESHQQETQ------------RLE
EKKES-TLDTRRKMNKK-DYL-------RYGSIFFGSVVTTLV-LLN-W-G---NSY---
YSSSAQQVPKNPALEAFLVHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHLVADAYTSSQKV--SAIQIDGAARTLQDSDVVKQLVDTELSSG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDFLWARFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRDI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------MS--S-----------QENPD--
TKKS------------I-LNSEEIEHKMTDSGLRDPPE--DSQK

PF05609 // ENSGT00390000012166_0_Domain_3 (285, 1019)

VLE---NDPSINSQAQ
ETTVTASAI---E-----EEAA--QTPHPASGLNE-----------DHQEVEANGLES--
------------------------ADT-D----------------DKS-ESPDETNIGSH
-PEDKT-----------------EHENSPSSEA--SAQG-HHFP-SEGLGENPQ---DPD
PSCSPSQE-VGRAPAGLGSA----------------------A-----EEPPAEDFPEAP
SPG-HSSAGPEG------------------------------------------------
------------------------------------------------------------
----------QDSLRRR----RPAP-E---------AESHEPETQ------------ILE
EKEEIAQDTTIRKITKK-NFW-------NYGFF-LGCLVIVAF-VLS-S-V---SSY---
YSSPVQQVPPNPALEAFLAQFSQLKDKFPGQSPFLWQRGRKFLQKHLNSSN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SAIMIDGADRAMNDSDTVKLWVDLELSSG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEATVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
SS-------------------

------------------------------------------------------------
------------------------------------------MGGVRHAQGPLREGRSRL
APQNGGG-SDAPAYGTPTPPRHS-RREVRFSEEPPEV--YGDFEPRA-AKEKVPV-----
--GR-QIPLEEFRP--------------DSAKEEVRESAYYLRSRRQ-RQPRLPEAEEMK
TRRGTRLQQQQ-QQPHSQPPPLQSSPVTTRRGLRDSHSSE------E---

PF05609 // ENSGT00390000012166_0_Domain_3 (291, 1019)

DETPS-----
------------------------QTVLSQTVSKKT---I-----MRTQE-TPV--VS--
------------------------ED--P-----VISLRRPPLRSSRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------END
QDSSDSD-----------------------------------------------------
---------------------------------------------------------VTT
VKFRSRD----SVASGDQTTRS-SSQYPESLWQSSQSG-DFITLDKQPL-VLSS-GY---
--QKNPQQWVEQTTRIRTRMQTSSPGK-RSIYGSFSDDDSVQKPEL--GNQSPSTS---S
Q-QVTGQAKT-TSFFKI--------------KWWWFPVVIV--ALAIGNF---WFSRT--
-----SEAETT-AVQEFQNQMKQLMNKYQGQDEKLWRRSQTFLEKHLNSSQPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--PAIRIDGAGKATQDSDIVKQEVDEELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLQVKFTNSDTPDSYKHMDP-DKLNGLWSRISHLVLPVQPENDL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------VSINMTDSGLRDPAQ--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
DARITESNT---E-------EA--KTPYLASDLKE-----------DHQQVGAEGSES--
------------------------ADT-G----------------AKS-EGSEEIEFEKY
-QKDET-----------------EPENSPSFQD--GEQG-YPRP-SEPLHEEAL---DPD
PECSPGDE-VGTADAHLGSSPATLPE------GA--GDRSGAF-----QGPHATDSTDAQ
SPS-HPSAGPES------------------------------------------------
------------------------------------------------------------
----------QDFLRRR----LPVS-D---------VGSHEEETE------------TVK
ENKEV-AQDTTRKTNKK-SLW-------SYGSILLSCLVVILV-LSS---V---HSY---
YSSPAQQVPKNPALEAFLAHFGQLKDTFPGQSSFLWQRGRKFLQKHLNVSN-PTEPATII
FTAAREGRET-LKCLSHHVANAYTSSQKA--TAISINGAERALQDSDTVKLWVDLELSSG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVMLED-ETLEANVGPRE
TEEKVRDLLWAKFTNSDTPNSFSRMDS-DKLSGLWSRISHLVLPVQPVQNI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGDGRWVEPVREGWGVYVTPRAPLREGRRRL
APQNGSG-SDASAYGSSFPSRHG-RREVRFSEEPPEV--YGDFEPRV-PKRRPPL-----
--GR-RTSPEKFRP--------------DSAKEEVKESAYYLRSRQR-RQPQPQEATE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
ARRAIRLQQQL-----SEQSLPQPSPVMTRRGLRNSYSSEV-S-PSE---DDPSS-----
------------------------QTVLSQPVSKKT---V------RTPE-VP--VVS--
------------------------ED--R-----VLSLCRPPLRNSRT-DSSYSTNGNSK
MSELEA----------------TSVQQKGSFSE--GETE------------------EDD
SDSSESD-----------------------------------------------------
---------------------------------------------------------VTV
GKVRSGD----SVDSGDQTIRS-ASRYPESFWQSSQSRDFTTAHDKQPS-VLSS-GY---
--QKNLQEWVEQTPRIRSRMQN--------------DNTHVQKSAL--GNQSPSIS---S
R-LKKIRNTNIPPWIIS-H------------W-RWLFLLIA--VIAIGIF---WSSRN--
-----PEVETT-AVQEFQNQMKQLMNKYRGQDEKLWKRSLTFLEKHLNSSIPRPQPAILL
LTAARDAEEV-LKCLSEQIADAYSSFRSV--RAIRIDGTGKAAQDSDTVKLEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLED-ETLETTLGLKE
IEEKVRDFLRVKFTSSDTPDSYNHMDS-DKLSGLWSRISHLVLPVQPENAL--KGGFCL-
---------------------

------------------------------------------------------------
----------------------------MEGERRLTQAL-GGWAIDVTPRAPIREPRRRL
APQ-NGDS-DAAAYGTHPSR-HG-RREVRFSEEPPEV--YGDFEPRV-TKERSPG-----
--GR-RTPPEKFRP--------------NSAKEEVRESAYNLRSRPR-RRRGPQEAEEMK
TRRSARMEQ--T----SQQPQPQLSPATSRRGLRNSQSSGE-DSGED---EPSSS-----
------------------------QTVTSQTASRKT---------VRTPD-AS--MMS--
------------------------ED--P-----ISNLCRPPLRSPRI-DSAYKTNGNTK
MSEIEA----------------VSI-HPV

PF05609 // ENSGT00390000012166_0_Domain_3 (450, 1019)

DFSE-E-------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------G-QDFTAHENQPS-VLNS-RC---
--QRNAQEWVEQVIRMRARLPYN----------------NIQESEF--GSQSSSNS---S
Q-QRADQPHS-ESSVNR-K------------W-WLAGLVAA---LVIGLF---WFFHT--
-----PAVETT-AVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLERHLNSSVPRPQPAILL
LTAAQDAKEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKQEVDQELSSG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLKASLGLKE
IEEKVRDFLKVKFTKSNTASSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KGGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------IFV--SLDS

PF05609 // ENSGT00390000012166_0_Domain_3 (285, 1019)

HLE---NDPSVNSKEQ
ETTVTASST---E-------EA--QTPCPASGLK------------DHQKLEAEGPES--
------------------------QGT-S----------------EKS-ENSHEANVEKY
-PKDKT-----------------EDENKLSFQD--GEQK-DHLP-SENLGKEPL---DPD
ANCFPCDK--ERADADLGSSSTSLPE--------EVKDRTEAS-----QVPSTTDLQEAQ
SPG-HSKEKS--------------------------------------------------
------------------------------------------------------------
----------QDSLRRR----QPAP-E---------TESHNQETH------------TLG
ENKKT-EQNTIKKIKKK-SFW-------NYGSIVFGCLVVVFF-VLK-F-V---NSY---
YSSPAQQVPQNPALEAFLAHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SAITIDGAERALQDSDTVKLVVDLELSYG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-EKLETNVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------S

PF05609 // ENSGT00390000012166_0_Domain_5 (896, 1011)

ELSSA
FQAGDRAAVIHRFELLPAGATLIFYKYCDHESAAFKDVALLLTVLLEE-EMLETHIRLQQ
VEERVRDFLWAKFTSARTPSSYDHMDS-DKLSGLWSRISHLVLPIHPVQNI---------
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDNGYVNPQEECQMKENLE---KD

PF05609 // ENSGT00390000012166_0_Domain_3 (293, 1018)

PTVTPQTL
EAIKASEVT---E-------ET--QIQCPVSGLKD-----------TPIEAETIGSQS--
------------------------LDA-E----------------NKS-ASTCEIDEGNS
-PETEQ-----------------EKEESQNDSI--SKQG-YSHN-TEGLCERPV---DQN
ISISLKEK-ESPTP-LQEKSSAVLTE------DNEKSTIP--------QKPNAD------
--------------------------------------------------------EKVP
---------D---AVG-----------------------------------------TQN
SVTAKEELENQVMVRKR------FIQE---------VRSHQQESV---------ETRRPE
ENKER-AQ-DVGKSPEK-TLWSK-------LGHTIGFLAVLIFV----VAF---ISS---
FSSQAQQVPKNPALEAFLDQFSQLKDKFPGQSSYLWQRGRKFLQKHLNASS-PVEPATII
FTAAQEGKET-LKCLSHHIADAYTFFQNV--SAIKIDGAHRTSQDSDTVKLLVDIELSTG
FEVGRKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEKSVGPRE
TEEKVRDLLWARFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVEKI--EEKGCFL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVNSQAQ
ETTIIASNA---E-------EA--EILHSACGLSK-----------DHQEVETEGPES--
------------------------ADT-G----------------DKS-KSPDEANVGKH
-PKDKT-----------------EDENKQSFLD--GGKG-HHLP-SENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPK--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPVILVVLV---VAVVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLEDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVSSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------MADRDPAE--VSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLK---NDPPISSQAQ
EITVPATTT---K-------EA--HTPDLASDLNK-----------VHQEVETVGPGS--
------------------------TDT-D----------------DQS-ESPDETNYENY
-PKDKT-----------------EHENNQSFQD--EEEE-HQLS-SESPNEKPL---DLE
PTCSPNDK-VGREDALFWSSSAALPE--------EVNSGPGVS-----QEPPAIDPQGTQ
SPA-FSPAAPES------------------------------------------------
------------------------------------------------------------
----------QSTVRRR----LLAP-E---------AESHQQETQ------------ELE
ENKEN-ALDTVRKMNTK-KFL-------SYGSIFFGFLVMTLF-LLS-C-V---NSF---
YSSPAQQVPKNPALEAFLVQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTDPATII
FTAAQEGRET-LKCLSHLVADAYTSFQKV--SAIQIDGTGRTLQDSDTVKHLVDVELSSG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLDE-KTLEASVGPRE
TEEKVRDLLWARFTNSDTPRSFNHMDS-DKLSGLWSRISHLVLPVQPVKSI--EEQGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------MSLDRQDKNMMDSGCSDPVG--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDSSVDSQAQ
GTTVTANDT----------EEV--QTAPPASDLKD-----------DHHEVEAKGQEQ--
------------------------ADT-G----------------DKP-ESSEEMALGKH
-PVDKA-----------------EHQSSPSSQD--TEQG-HHPP-SEHLGGEAL---QLD
PNCSQSSK-GGTAGAHLGSSSTGL------------------------------------
------------------------------------------------------------
-----------------------------------PEGAGDRCEAAQEPLATDS-TDAPS
PVHSSADPGSQDLLRRR----LPVS-E---------AGSPEEETK------------LVK
EKQEAAQD-SLRKTDKK-SLW-------SYGLLFLCCLIVALV---L-SSI---NSY---
YSSLAQQVPQNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNVSN-PTEPATII
FTAAQEGKET-LKCLSHHVANAYTSSQKV--SAVSIDGAERALQDSDVVKLWVDLELSSG
FKNGNKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALILTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSETPSSFSHMDS-DKLSGLWSRISHLVLPVQPVKNI--EERGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------MVGDGEEQ
------------------------------------------------------------
------------------------------------------------------------
--APPHAPELKHRRKSPRFAAEAEPDSGGAQEGGEP---AFGSPGS-LT-----------
---------------------------RPPIRACRVVGGSSSSFLPESPAK-E

PF05609 // ENSGT00390000012166_0_Domain_3 (594, 1018)

KVNDYDV
S--EPKNPAG---DQPN------AYTPLKESKADFSEKTQ-----------------EYH
A----TKSQSRSKF-----------------------RDQPSTGK------------QSQ
HL---AK-----KDGSQSGFP--------KGWTLLLVLLVSISLFSI-LWI---KGLN--
LPDATLSIRNTQILQAFRTRMKKLRNTYQSQDPNLWKRTHVFLERHLNTSHLHLEPAILL
FTAGQEAEKA-LRCLSDEIANAFAFSQNG--TTIKINGADKAILDSDVVKLEVDDELSSG
FREGKKVAVVHRFELLPAGSTLIFYKYCDHENAAFKDVALLLTVLLDE-QSLRRSLTLKE
VEEKVRDFLWTKFTSSDAPSSFNSIDT-DKLSGLWSRISHLVLPVWPEKGL--PIEGCT-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MTDRGLRDPPQ--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KNLE---NDPSVSPQAR
ETTVTASTT---E-------EA--QTPDPASGLNK-----------DHQEIQSIGPES--
------------------------TEV-G----------------DQS-ASPDETNYGKD
-PEDV------------------EGENNQSFQD--GEPG-NPLP-SES-EEEPL---DPE
PSCSPSDK-MGRTDPHSVSSSAALPE------DEDVTDRPGAS-----REPPAADPEDAQ
SPG-GSSAGLEG------------------------------------------------
------------------------------------------------------------
----------QDALRRR----LLAP-E---------AERHQQEIQ------------KLE
ENKEN-AQDTGRKINKK-DFL-------SYGSIFLGFMVLTLV-LLS-S-V---NSY---
YSSPAQQVPKNPALEAFLVHFSQLKDKFPGQSSFLWQRGLKFLQKHLNSSN-PTEPATII
FTAAREGRET-LRCLSHHVADAYTSSQKV--SAIQIDGAGRTLQDSDKVKHSVDMELSSG
FEKGQKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EEQGCSL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------VSRSLKRENKNMTDRGLRDPPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETAVT-STT---E-------EA--QTPNPASGLNK-----------DHHEVETIGPAG--
------------------------ADT-G----------------DQS-ESPKETNDGKS
-PKDKT-----------------EHENNQSCQD--GEER-HPSP-SENLGKDPL---DPE
PSHSPGEK-VGRADAHGGSGPAALAE--------EASARPGAS-----REPSAADPQDAQ
RDT-EEARARAGASKLRDEKS------------CSN------------------------
------------------------------------------------------------
--LNPATSLYVTLLKRR----CPVMLK---------AESHQQETQ------------KLE
ENKEN-VHDTLRKTNKK-DFC-------NYGSIFVGFLVVTLV-LLG-C-V---SSY---
YSSPAQQVP-NPALEAFLVQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASH-HTEPATII
LTAAREGRET-LKCLSYHVADAYTSSQKV--SAIQIDGAGRTLHDSDTVKLLVDMELSSG
FENGQKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLDE-ETLEASVGLRE
TEEKVRDLLWARFTDSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------------CIF

PF05609 // ENSGT00390000012166_0_Domain_3 (601, 1019)

RFHSQH-PEC-RWSSKSQEI-----K-L----------------PNKQSPLPTF-QP---
--LIKPQELSGQNARQRTKLPN----------------DNFHKSDL--RNKSQLTL---N
Q--NQ--SKK-KS-SVK-V------------W-LLVLLVILVAPGIF--------DFT--
-----TSVETT-AVQKFQNQMKRLMNKYRSQDEKLWKRSQTFLEKHLNSSHPRPQPAILL
LTAAQDAEET-LRCLSEQIADAYSSFYRV--RAIRINGTGRSTQNSDSVKLEVDQKLTDG
FSNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALILTVLLEE-KTLGTDLGLKE
VEEKVRDFLKAKFTSSDTPNSYNHMDS-DKLSGLWSRISHLVLPVQPENSL--KSGVCL-
---------------------

------------------------------------------------------------
----------------------------MAGEGQRAEPEREGWALYVTPRAPLREGRPRL
APQNGGS-GDVPAYGTPTPSRHG-RREVRFSEEPPEV--YGDFEPRA-AKEKARV-----
--GR-QIPLEGFRP--------------DSAKEEVRESAYYLRSRQR-RQPRLHEAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MQ
TRRAALLQ----QQPHSPPPPLRPSPVTTRRGLRDSHSSE------E---DEPPS-----
------------------------QTVLSQTVTKKA---I-----RRTQE-TPV--MS--
------------------------ED--P-----LISLRRPPLRSSRS-E----------
-----A----------------ASVQQKVNFLE-EGETE------------------END
QDSFDSD-----------------------------------------------------
---------------------------------------------------------VT-
VKVRSGD----SVESGDQTTRS-SSQYKESFWQSSQSG-DFTAFDEQPL-KLSS-GY---
--QKTPQEWAEKTVRIRTRMLTSSPGM-RSIYGSFSDDDSVQKSEL--GNQSPSTS---N
Q-QMTGQPKS-VSSVKT--------------KRYWPFAVIA--ALLIGGF---LYTRP--
-----PEAETT-AVQEFQNQMKQLMNKYQGQDEKLWKRSQTFLEKHLNGSQSRPQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--PAIRIDGASKATRDSDTVKEEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHESAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLQVKFTNSDTPNSYKHMDP-DKLSGLWSRISHLVLPVQPENDL--KKGICL-
---------------------

------------------------------------------------------------
----------------------------MAGERWQAEGPGEGWAIYVTPRAPIREGRRRL
DPR-NGDSSDAPAYGAHPSR-RG-RREVRFSEEPAEV--YGDFEPRA-AKERSPG-----
--GR-RTPPEKFRP--------------ASAGEEVRESAYNLRSRPR-RQRRAQEAEEMK
TRRSARLEQ--H----SQQ--PQLSPATSSRGLRDSPSSSE-DREED---EPS-S-----
------------------------RPVTSQTASKKT---------LRTPE-AS--VMN--
------------------------ED--P-----ISNLCRPPLRSPRL-DSTYRTNGNTK
TNEREA----------------TIV-QQVNFFE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------IT-
IRARSSD---

PF05609 // ENSGT00390000012166_0_Domain_3 (611, 1019)

-SLESRD---------------------QDFPAHENQPL-LLTS-GC---
--QENPQEWVDRAVRMRSRMAYN----------------NIQKSNF--GNQSPSTS---R
P-QSAIHHPN-EPSVKI-K------------W-WLLGLVAI---LAVGLF---WFFHT--
-----PAVETT-AVQEFQNQMKQLQSKYQSQNEKLWKRGTTFLEKHLNSSLPRPQPAILL
LTAAQDAAEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKHEVDQELTDG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLEASLGLKE
IEEKVRDFLKVKFTSSSTASSYNHMDP-DKLNGLWSRISHLVLPVQPENTL--KAGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------------------------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (291, 1019)

DEPSP-----
------------------------QHTLGPTGTKKS---M------IVQE-VP--VLI--
------------------------DD--P-----ISELRRPPLRSPGPXX----------
----------------------XXXXXXXXXXX-XXXXX------------------XXX
XXXXXXX-----------------------------------------------------
---------------------------------------------------------XXX
XXXXXXX----XXXXXXXXXXX-XXXXXXXXXXXXXX-QDFTVRDHQPS-GLSS-GY---
--PKASQEWNEQTGGIRSRRPNE----------------NLLKPEF--RNQRLPSP---A
P-QTSGLSKE-PFSAQR-V------------WCWALLL-VA---APPCAR---GGSCT--
-----PEVD-SPAVHEFQHQMQQLRRRYRGQDEALWRRGGALLEKHLNGSRPRPQPAILL
LTAARDAEDA-LRCLGEHLADAYAAALARRAPAIRIDGAGLAARDSSAAKLQVDLELSRG
FEGGRAAAVVHRFESLPAGATLIFYKYCDHEHAAFKDVALVLTVLLED-TTLGASPDLKH
VEEKVRDFLRVKFIDAGAPSAHDRMDA-DKLSGLWSRISHLVLPVQPEHAQ--EHGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACGLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPA-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----PLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAGEGWWAEPEREGWSVHVTPRAPLREGRRQP
APQDGSG-SDAPAYGTASPSRHG-RREVRFSEEPPEV--YGDFEPWV-VKERLPI-----
--GK-RTSPEGFRP--------------DSAKEEVKESAYYLRSRQR-RQPRPPEAME

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRATRLQQQHQQ---SEQSLPQPSAVLTRTGLRNSHSSEX-X-XXX---XXXXX-----
------------------------XXXX-------X--XX-----XXXXX-XXXXXVS--
------------------------ED--P-----VISLRRPPLRNARS-E----------
-----A----------------TSVQQKGSFSE-EGETE------------------EDD
PDSSDSD-----------------------------------------------------
---------------------------------------------------------VAA
SKGRTRD----SVESGDQTRD------------------FTAPYDKQPS-VLSS-GY---
--QRNPQEWVEQTPRFRSRMQN--------------DSVHIQKSSL--GNQSASTS---S
Q-QFTGQPKT-TGFVK--K------------W-CWLLLPIA--AVTIWSF---WSGSS--
-----PEVEST-AVQKFKNQMEQLKNKYQGQDEKLWRRSITFLEKHLNSSQPRPQPAILL
LTAARDAEEV-LKCLSEQIADAYSSFHRV--RAIRINGTSKAAQDSDTVKLDVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-DTLETSLGLQE
IEEKVRDFLRVKFTSSDSPDSYRHMDP-DKLSGLWSRISHLVLPVQPEDAL--RGGLCL-
---------------------

------------------------------------------------------------
----------------------------MAGERWRAGPELEGWAANVTPRAPLRQEKLPL
APQDGGG-SNALAYGSPSGQRRR-RREVRFSELPPQV--YGDFEPLA-SGGSAPV-----
--EK-QSPKQEFRL--------------SPGKEEVVEAYLRSQQGTH-LS--RLGPVE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MN
TRRTTRLQQ------QEAKPPAQPSPATTRRGLREPKSP------EE---DEPSS-----
------------------------QTIISQTVSKKS---I-----KRAQE-IPVANED--
------------------------ST--I-----IGDLRRPPIKSSGFDYSSFGTNGNSK
MKETG-----------------VTRMENVDFSE-EDP-E-----------------EEEV
EQQNISD-----------------------------------------------------
---------------------------------------------------------SDA
NPPSPS-DED-STKSRGQEI-----K-L----------------PNQQSPLLTS-QV---
--PAKLPEWSGQNARLRTKLPTSTLSKKNLIHDHFSDDDNCHKSEL--RNRSLLSV---N
L-RDQ--SKK-KS-SVK-F------------W-LLLMLISGVVPGFLY-M---NWPFA--
-----TNVKTT-AVKEFQNQMKKLMKKYQSQDEKLWKRSQTFLEKHLNSSHPRPQPAILL
LTAAQDAEET-LRCLSEQIADAYSSFYSV--RAIRINGTGTSTQDSDYVKLEVDQKLSSG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALILTVLLEE-KTLGTDLGLKE
VEEKVRDFLKAKFTSSDTPNSYNHMDS-DKLSGLWSRISHLVLPVQPENSL--KSGVCL-
---------------------

------------------------------------------------------------
----------------------------MAGEGPRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRHPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSRN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDNIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFGKR-N------------C-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGEGPRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSHN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDNIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFGKR-N------------C-WWLLPLIA--ALASGSL---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-PPSRQG-RREVRFSDEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRS--------------DSAKEEVRESAYYLRSRQR-RQPRPQETEEMK
TRRTTRLQQQH-----SEQPPLQPSPVMTRRGLRDSHSS------EE---DEASS-----
------------------------QTDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----VIRLRRPPLRYP

PF05609 // ENSGT00390000012166_0_Domain_3 (407, 1019)

RS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKTTRS-SSQYIESFWQSSQSQN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARIRTRMQTSSPGK-SSIYGSFSDDDSILKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------R-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDAVKLEVDQELSNG
FKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADTGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KNLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSAYGLSK-----------DHQGVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-AENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-A---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------NI

PF05609 // ENSGT00390000012166_0_Domain_6 (897, 1019)

LTAG
FQDTSSAAVLHQIESLHPGALLILYKYCDHENAAFKNVALVLTVLLED-SELEPQLSLTE
IEEKVRDFINEKMVSSKNAESHSEMDV-DKLSGVWSRISHTVLPVYPEDNF--ADCGGTE
--QGL----------------

------------------------------------------------------------
----------------------------MAGEGRRAEPPMERWGVYVTPRAPLREGGRRR
APQDGVG-SDAPAYGTPSLLCHG-RREVRFSEEPPKV--YRDFEPRA-AREKSPV-----
--EK-RIPLEEFRP--------------DAAKGEVRESAYYLRSQQR-RQPPRREAEE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MK
TRRAARLQQQ-----HAEQPPPQPSPATTRRALRDSHFSE------E---DEPSP-----
------------------------QTVLSQTASKKT---I-----RTQ----ETLVAS--
------------------------ED--P-----VISLRRPPLRSSRS-E----------
-----T----------------TSVQQKVNFSE-EGDTE------------------EDD
SDV-SSD-----------------------------------------------------
---------------------------------------------------------VTS
VKVGPGA----SVESEAQTS-G-GSQYSESFWQSSQSR-DVTALDKQS-------VY---
--QTTPREWVQQTTRIRTRM----------------QNDRLQKLEL--RNRSPSAS---S
Q-HVTRQPQN-ASSVKI-K------------WWWWLLVPIV--IFAVGYW---WYPLT--
-----PEAETT-AVKEFQNQMKQLMNKYQGQDEKLWKRSQTFLEKHLNSSQPRPQPAILL
LTAARDAEEV-LKCLSEQIADAYSSFRSV--RAIRIDGTGKATQDSDAVKLEVDQELTNG
FRNGQNAAVVHRFESLPARSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLRVKFTNSDAPNSYKHMDP-DKLSGLWSRISHLVLPVQPEDAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADTGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KNLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSAYGLSK-----------DHQGVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSHSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA-SSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQVQ
ETTIMASNA---E-------EA--QTLHSACVLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANMGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPN
PSHSPSDK-VA--DANLGSSSVAPPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSIAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTVRQINKK-SFW-------SYGPIFLFFLVVV---VVA-SSV---NSF---
YSSPAHQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQKV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------NTNMTDIGLSDPQEV-DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NVPSVSSQAQ
ETTVTARGT---R-------EA--QTPYSASGLNQ--------------RVEVIGPGS--
------------------------ADT-G----------------DEP-ESPDETTGQKY
-PKEET-----------------EHESNRSSQD--GEEG-HHFH-PGSAGAEAS---DPD
PDCSPSDR-GARVDAHFRSHSARPSE------GAGESGHTEEAAGGTSQVLPINKAQGGR
SDS-HLCFAVQGKGQ--------SVTANFHYESCSH--------MPPQRSVSAEASDPDP
----DRSPSD---GGER------ADAHFRSHSAAHPEELRVRTTASQEPPAPDF-QNAQS
PGHFITGLESQDTLRRR----LGAP-E---------AGSHLQEAQ------------KLK
GNKEK-AQDSRRKIFSH-SLT---------GYIVFALLAIGLCIFLL-RPI---TRD---
YFSQAQQVPKNPALEAFLAEFTRLKDKFPGQSPFLWQRGRKFLQKHLNVSD-PTEPATII
FTAAREGRET-LKCLSYHIADAYTSSRKV--SAIQIDGATRSSQDSDTVKLWVDVELSSG
FENGRKCAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWARFTNSNAPNSFNRMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGEGPRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-PLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RSRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE---DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLC

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSRN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDNIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFGKR-N------------C-WWLLPLIA--ALASGSL---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLRDTPE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDFE---NDSSINSQAP
EITVTSSNI---E-----DE-----TQQPVSSLNE-----------DFQEVEDLKAFEEE
SLASAQAP--S-------SSPRTGTET-G----------------DKS-ASPDETNFREH
-PEDKT-----------------EHENNPSFQD--GEQE-DHLPS-K-------------
---SLREE-IGRVDAHSRGSSADLPV------GA--SGGNRAS-----QEPPAGALG-GQ
SLV-HFSTG---------------------------------------------------
------------------------------------------------------------
-------PESQDLLRRR----LPVS-E---------IGSQEEEIH------------TAE
ENQKI-TEDSIRKTDKK-NFVSDSCSLSIFGPIFFGCIIGAFVLI---SVV---NSY---
YSSPAQQVPQNPALEAFLAQFGQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PSEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKG--SAIMIDGAERALQDSDTVKLFVDLELSHG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-DTLEANVGPRE
TEEKVRDLLWAKFTNSATPSSFNHMDS-DKLSGLWSRISHLVLPVQPVKNI--EEHGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIITSTA---E-------EA--QTLHSAAGLSK-----------GHQEVETIGPEN--
------------------------VVT-G----------------DKS-ESPDEANVGKH
-PKDQI-----------------EHENNQSFLE--GEKG-HHLP-SESLSEEPL---DPD
PSHSPSDK-LGRADEHLGSSSAALPT--------EVIDGMGAP-----QEPPAAGSQEAE
GPG-HSSAGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LLVP-E---------AGSHPQQTQ------------KSE
EIKEN-TRDTMRKTNEK-SIW-------NYGPVFLSLLFGA---LVL-TSV---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAREGRET-LKCLSHHVADAYTSSQKV--SPIQIDGAGRTWQDSDTVKLLVDLELSSG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWSKFTNSDTPRSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

PGGGSDPQQLTQPRHCLFH-SPQDTSWAQMQVCGTAATTQAAAPATLNCLPNHRDHRPTP
PRSHRHHRPNKLGAAEPPSRSTQDTSTTMEGDGRRAEPMLEAWGMYVTPRAPLREARRRL
APQNGGGGGGAPAYGT-PLARQG-RREVRFSEEPPEV--YGDFEPRV-AKERFPV-----
--GR-RTQPQEFRP--------------DSVKEEVRESAYNLRSRQR-RQSRPQKAGE

PF05609 // ENSGT00390000012166_0_Domain_3 (239, 1019)

MN
TRRAARLQQQQN----AQQPPLQPSPVTTRRRLQDSQSS------EX---XXXXX-----
------------------------XXXXXXXXXXXX--XX-----XXXXX-XX-------
--------------------------------------------XXXX-XXXXXXXXXXX
XXXXXN----------------TSVQQKVNFSE-EGETE------------------EDD
PESSDSD-----------------------------------------------------
---------------------------------------------------------GTT
VKVRSGD----SVESGDQNTSS-SSQYPGSLWLSSQSQD-LIAHDKQPS-VLSS-GY---
--QENPQEWVKQTPRMRTRIP----------------NDGIQKSQL--GNQSPSTS---S
Q-QMTGQPKN-ASFIKM-S------------W-RWLLFPIA--ALVFGYF---WFVPI--
-----PEVETT-AVQEFQNQMKQLMDKYQGQDEKLWKRSQTFLEKHLNSSHPRAQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFRSV--RAIRIDGADKASQDSDVVKLEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGASLGLKE
IEEKVRDFLKVKFTNSNTPNSYNHMDA-DKLNGLWSRISHLVLPVQPENAL--KRGVCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------DTDMADSGFRDPRE--DSPKDLE---SEPSVDSHAQ
ETAVTASPP---A-------ET--QALPPASDLDK-----------DHQ----EGPES--
------------------------ADA-G----------------GTA-EGPGPADFGDH
-PKATA-----------------EPESKPGVPD--GEQG-HQVP-WGSLGGEPL---GLD
PNCSPSDE-VGRAGAQPGSSSVALPE------GA--SDGAAAA-----LGAPAAASQEAH
GPG-PRSAGLDSRDALRRRQPAAGKNLRRSIQGCGA--------V

PF05609 // ENSGT00390000012166_0_Domain_3 (586, 1019)

TEDAAQVPAAS-AAP
----AQ-QSD---EVGR------AGAQPGSSSVALPEGASDGASAALGAPAAAS-QEAHG
PGPRSAGLDSRDALRRR----QPAA-D---------ARSHGQESQ------------KLE
ENKEN-AQDTIRKINKK-DLW-------SYGPVFLGLLVTALV-LSS---V---NSY---
YSSPAQHVPENPALEAFLAQFSQLKEKFPGQSPFLWQRGRKFLQKHLNASE-PSEPATVI
FTAAREGRET-LRCLSHHVADAYTSSQQV--SALQLDGAERASQDSDTVKLWVDLELSSG
FENGHKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDMPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EERGCLL
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-PPSRQG-RREVRFSDEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRS--------------DSAKEEVRESAYYLRSRQR-RQPRPQETEEMK
TRRTTRLQQQH-----SEQPPLQPSPVMTRRGLRDSHSS------EE---DEASS-----
------------------------QTDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----VIRLRRPPLRY

PF05609 // ENSGT00390000012166_0_Domain_3 (406, 1019)

PRY-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKTTRS-SSQYIESFWQSSQSQN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARIRTRMQ----------------NDSILKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------R-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MEGDRRLTQAPGGGWAIDVTPRAPIREPRRRL
APQ-NGDSSDAPAYGTHPSR-HG-RREVRFSEEPPEV--YGDFEPPV-TKERSPG-----
--GR-RTPLEKFRP--------------DSAKEEVRESAYNLRSRPR-RRRGPQEAEEMK
TRRSTRLEQ--T----SQQPQPQLSPATSRRGLRDSQSSGE-DGGED---EPSSS-----
------------------------QTVTSQTASKRT---------VRTPD-AS--MMS--
------------------------ED--P-----ISNLCRPPLRSPRS-DSTYKTNGNSK
MSEIEA----------------VST-QPVHFSE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------TT-
VKVRSRN----S

PF05609 // ENSGT00390000012166_0_Domain_3 (613, 1019)

VESR--------------------G-QDFTAHENQPS-VLNS-RC---
--QKNAQEWVEQVIRMRTRLLQN----------------NIQESEF--GNQSPSTS---G
Q-QPAEQPDN-EPSVNR-K------------R-WLLGLVVS---LAIGLL---WFFYT--
-----PAVQTT-AVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLERHLNSSVPRPQPAILL
LTAAQDAKEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKQEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLKASLGLKE
IEEKVRDFLKVKFTNSNKASSYNHMDP-DKLNGLWSRISHVVLPVQPENAL--KGGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------------------M-----KRTQGAAAAVSVG--
------------------------SE--S-----VADLCRPPIRSSGSEYSSFGTNGDAK
LNETDKREMKKRQRKLEAEY

PF05609 // ENSGT00390000012166_0_Domain_3 (441, 1019)

AGGGRVQKVDFSE-EGETG-----------------EEDN
QDSSGSE-----------------------------------------------------
---------------------------------------------------------GTS
AKPTDG-DSA-SPKDFRPLS-----K-FPDSFKKPIS-----NYTNFSSSSLVP-PS---
--TTKLQEWSDQKTQIRNRLQNDSHYKL----------------NV--GNKLSSHV---Q
K-TEPTGQSK-ERTSAK-I------------W-LWVIVIAVILVACVLGL---WYKFM--
-PESSLSGEIT-AVQRFQFQMKQLMNKYPSQDEKLWKRSQIFLEKHLNSSHPRLQPAILL
LTAARDAEEV-LRCLSERIADAYSSFFSV--SAIRIDGAGKAAQDSNVVKMEMDSQLNDG
FKNGKKAAVVHRFESLPAGSTLIFYKYCDHENAAFKEVALVLTVLLEEEETLGTSPDLKE
IEEKVRDFLKVKFTNSDTPNSYNHMDS-DKLSGLWSRISHLVLPVQPENAL--KSGSCL-
---------------------

------------------------------------------------------------
----------------------------MAGERWQAEGPGEGWAIYATPRAPIRERRRGP
DPQ-NGDSSDAPTYGAHPSR-RG-RREVRFSEEPAEV--YGDYEPRA-AKETSPG-----
--GR-RTPPEKFRP--------------ASAREEVRESAYNLRSRPR-RQRRAQEAEEMK
TRRATRLEQ--H----SQQ--PQLSPSTSGRGLRDSQSSSE-DRGED---EPS-S-----
------------------------QPVTSQIASKKT---------VRTPE-AS--AMN--
------------------------ED--P-----ISNLCRPPLRSPRL-DSTYQTNGNTK
RNEREA----------------TIV-QQVNFFE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------IT-
IRVRSND----SLESRG--------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (638, 1019)

-QDFPAHENRPL-LLTS-GY---
--QKNPQEWVDQAVRMRGRMAYN----------------NIQKSNF--GNQSPSTS---R
Q-QVAVQPPN-ESSVKI-K------------W-YVLGLVAT---VAV-LF---WSFST--
-----PAVETT-AVQEFQNQMKQLQSKYQSQNEKLWKRGTTFLEKHLNSSLPRPQPAILL
LTAAQDAAEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDIVKHEVDQELTDG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLEASLGLKE
IEEKVRDFLKVKFTSSSTANSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KAGSCL-
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-PPSRQG-RREVRFSDEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRS--------------DSAKEEVRESAYYLRSRQR-RQPRPQETEEMK
TRRTTRLQQQH-----SEQPPLQPSPVMTRRGLRDSHSS------EE---DEASS-----
------------------------QTDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----VIRLRRPPLRYP

PF05609 // ENSGT00390000012166_0_Domain_3 (407, 1019)

RS-E----------
-----A----------------TSVQQKVNSSE-EGETE------------------EDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKTTRS-SSQYIESFWQSSQSQN-FTAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARIRTRMQTSSPGK-SSIYGSFSDDDSILKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------R-WWLLPLIA--ALASGSF---WFFST--
-----PEVETA-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
----------------------------MEGDRRLTQAPGGGWAIDVTPRAPIREPRRRL
APQ-NGDSSDAPAYGTHPSR-HG-RREVRFSEEPPEV--YGDFEPPV-TKERSPG-----
--GR-RTPLEKFRP--------------DSAKEEVRESAYNLRSRPR-RRRGPQEAEEMK
TRRSTRLEQ--T----SQQPQPQLSPATSRRGLRDSQSS------

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1019)

ED---EPSSS-----
------------------------QTVTSQTASKRT---------VRTPD-AS--MMS--
------------------------ED--P-----ISNLCRPPLRSPRS-DSTYKTNGNSK
MSEIEA----------------VST-QPVHFSE-EGETE-------------------DD
LESSYSD-----------------------------------------------------
---------------------------------------------------------TT-
VKVRSRN----SVESRDEATRS-SSYCQESSWRLPQS-QDFTAHENQPS-VLNS-RC---
--QKNAQEWVEQVIRMRTRLLQN----------------NIQESEF--GNQSPSTS---G
Q-QPAEQPDN-EPSVNR-K------------R-WLLGLVVS---LAIGLL---WFFYT--
-----PAVQTT-AVQEFQNQMKQLQSKYQSQDEKLWKRGTTFLERHLNSSVPRPQPAILL
LTAAQDAKEV-LKCLSEQIADAYSSFRSV--RAIRIDGAGKAAQDSDLVKQEVDQELSNG
FRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-KTLKASLGLKE
IEEKVRDFLKVKFTNSNKASSYNHMDP-DKLNGLWSRISHVVLPVQPENAL--KGGSCL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------------------------MADSGLREPQE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSINSQAQ
ETTIMASNA---E-------EA--QTLHSACDLSK-----------DHQRVETVGPES--
------------------------ADT-G----------------DKS-ESPDEANVGKH
-PKDKI-----------------EDENNQSFLD--GEKG-HHLP-SENLGEEPL---DPD
PSPSPSDK-VGRADAHLGSSSVALPN--------EASDGTGAS-----QEPPTTDSQEAQ
SPG-HSITGQEG------------------------------------------------
------------------------------------------------------------
----------EDTLRRR----LPAP-E---------AGSHPQQTQ------------KLE
EIKEN-AQDTMRQINKK-GFW-------SYGPIFLLFLVVA---VVA---R---NSY---
YSSPAQQVPKNPALEAFLAQFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FTAAQEGRET-LKCLSHHVADAYTSSQNV--SAIQIDGAGRTWQDSDTVKLLVDLELSYG
FENGQKAAVVHHFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSDTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLF
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYGT-SLSRQG-RREVRFSEEPPEV--YGDFEPLV-AKERSPV-----
--GK-RTRLEEFRP--------------DSAKEEVRESAYYLRSRQRRRLPRLQEAEEMQ
TRRATRLQQQY-----SQQPPLQPSPVTTRRGLRDCHSS------EE--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------ETDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----AISLCRPPLRHPRS-DSTYKTNENTK
TSQLEA----------------TSVQQKVNFSE-EGETE------------------EDD
QDSSQSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDKATRS-SSQYTESFWQSSQSHN-FTAHDKQPS-VLSS-GY---
--QRTLEEWAPQTARIRTRMQTSSPGK-SSIYGSFSSDDSIQKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVKR-N------------C-WWLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQIFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFHSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGQNAAVVHRIESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDP-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------

PF05609 // ENSGT00390000012166_0_Domain_3 (294, 1018)

SVNSHEQ
KTTVTASST---E-------EA--QTPYPASGLNK-----------DNQELEAESPEK--
------------------------PHT-G----------------ETP-ESSDETNFAKY
-PKDET-----------------ENEDNLSFQD--GERK-DHLL-AENLDKEPL---DPD
ANHFPSDK--ERVDTNFGSSSASLLE------KV--NHETEAS-----QESCTTDPQEDQ
STD-CLKY----------------------------------------------------
------------------------------------------------------------
--------------CFF----FFFFPE---------TESPEQETQ------------TLG
EKKDI-AQDTIKKINKK-SFW-------NYGSIFCTLLVGAVV-LC---FV---ISH---
CSSPAQQVPQNPALEAFLAHFSQLKDKFPGQSSFLWQRGRKFLQKHLNASN-PTEPATII
FAAAQEGRET-LKCLSHCIADAYTSAQKV--SAITIDGAERALQDSDTVKLIVDLELSYG
FENGQKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDEALVLTVLLEK-ETLEANVGPRE
TEEKVRDLLWAKFTNSNTPSSFNHMDS-DKLSGLWSRISHLVLPVQPVRNI--EERGCFL
---------------------

------------------------------------------------------------
----------------------------MAGDGRRAEPGREGWGLYVTPRPPLREGRRRL
APQNGGG-SDAPAYGISSPSRLG-RREVRFSEEPPEV--YGDFEPRV-AKEKSPA-----
--GR-RVPLEEFRP--------------DSEKEEVRESAYYLRSRQR-RQPRLQEAEEMK
TRRTTRLQQ---Q--QSQQPLLEPSPVTTRRGLRDSHSSE------E--

PF05609 // ENSGT00390000012166_0_Domain_3 (290, 1019)

-DEPSS-----
------------------------QTILSQTVSKKT---V-----QRTQE-IPV--LS--
------------------------ED--P-----VISLCRRPLRSPRP-DSAYKTNGNTK
MSELEA----------------TSSQQKVNFSE-GEETE------------------QDD
QDSSDSD-----------------------------------------------------
---------------------------------------------------------ITI
LKVRSGD----SLDSGDQTTK--SSQYPESLWRSSQSR-DFITLDKQPS-VLSS-GY---
--QKKPQEWFEQSTRIRTKMQTSSPDR-SSIYGSFSDDDSIQKSEL--GNQFPSTS---S
Q-KAAGQPKS-ASFVKM--------------KWWCLLVLVA--SFAIGSF---LFVRT--
-----PEVKTT-PVQEFQNQMKQLMNKYQGQDEKLWKRSLTFLERHLNSSQPRPQPAILL
LTAARDAEEA-LKCLSEQIADAYSSFHSV--RAIRIDGADKATQDSDTVKEEVDWELSNG
FTNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
IEEKVRDFLKVKFTNADTPNSHKHMDP-DKLSGLWSRISHLVLPVQPENAL--KSGICL-
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------MSQSLKSQNTNMSDSGCRDPVG--DSQNV

PF05609 // ENSGT00390000012166_0_Domain_3 (286, 1019)

LE---NDPSINSQTQ
DTRVTPSNT--A--------EA--QSLQPTSDLKE-----------DHHEIGARAQEH--
------------------------TDT-G----------------DRS-ESPEEPALEKP
-PLDKA-----------------ELESSPSSQD--TELG-HHPH-SEHAGRDAL---DLD
PNCSQSDL-GGRADAHLESSSAASPE----------------------------------
------------------------------------------------------------
-------GAC---DRGE------ADEHLESSSAAPTEGAGDRGEAGQELLAEDS-TDGQS
LGHSNTGPGSQDSLRRR----LPVP-E---------AGSHEEETE------------LVK
EKQEVAQD-TLRKTDKK-SLW-------TYGSVFLGCLIVAVV---L-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFGQLKEKFPGQSSFLWQRGRKFLQKHLNASN-PSEPATII
FTAAREGKET-LKCLSYHVANAYTSSQKV--TAVSIDGAERALQDSDTVKLLVDLELSDG
FENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVSPRE
IEEKVRDLLWAKFTNSESPTSYSHMDS-DKLSGLWSRISHLVLPVQPVRNI--EERGCLL
---------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------ASQTLESDTDMADSSCRDPVE--DSQ

PF05609 // ENSGT00390000012166_0_Domain_3 (284, 1019)

KDLE---NDPSVSSQAQ
GTTVTPNDT----------KEA--QTPHPASDLKT-----------HQHEVEAKGQEH--
------------------------ADT-G----------------DRS-GSSEDAAVGRH
-PMDKA-----------------EHKSTPHSQD--PEQE-RHPT-SEHLDAEAL---HLD
PACSQSSK-RGRADAHLGSRSAAP------------------------------------
------------------------------------------------------------
-----------------------------------PEGAGDRCDAAQEPLAADATTDAQS
PGHCSAGPGSQDVLRRR----LPVP-E---------AGNPEEEMQ------------LVK
EKEEIAQD-TLRKIDKK-NLW-------SYGPVFLVCLVVALV---L-SSV---NSY---
YSSPAQQVPQNPALEAFLAQFSQLQDKFPGQSSFLWQRGRKFLQKHLNVSS-PSEPATLI
FTAAREGKET-LRCLSHHVANAYTSSQRV--SAVSIDGAKRAQQDSDTVKLWVDVELSSG
FENGHKAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLEASVGPRE
TEEKVRDLLWAKFTNSEAPSSFSHMDA-DKLSGLWSRISHLVLPVQPVRSI--EEQGCLL
---------------------

------------------------------------------------------------
----------------------------MAGEGRRAEAVREGWGVYVTPRAPIREGRGRL
APQNGGS-SDAPAYRT-PPSRQG-RREVRFSDEPPEV--YGDFEPLV-AQERSPV-----
--GK-RTRLEEFRS--------------DSAKEEVRESAYYLRSRQR-RQPRPQEAEEMK
TRRTTRLQQQH-----SQQPPLQPSPVMARRGLRDSHSS------EE---DEPSS-----
------------------------QTDLSQTISKK---TV-----RSIQE-AP-AVS---
------------------------ED--L-----VISLR

PF05609 // ENSGT00390000012166_0_Domain_3 (400, 1019)

RPPLRYPRS-E----------
-----A----------------TSVQQKVNFSE-EGETE------------------DDD
QDSSHSS-----------------------------------------------------
---------------------------------------------------------VTT
VKARSRD----SDESGDNTTRS-SSQYVESFWQSSQSRN-FIAHDKQPS-VLSS-GY---
--QKTPQEWAPQTARIRTRMQTSSPGK-SSICGSFSDDDSILKSEL--GNQSPSTS---S
R-QVTGQPQN-ASFVRR-N------------L--WLLPLIA--ALASGSF---WFFST--
-----PEVETT-AVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILL
LTAARDAEEA-LRCLSEQIADAYSSFRSV--RAIRIDGTDKATQDSDTVKLEVDQELSNG
FKNGRNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEE-ETLGTSLGLKE
VEEKVRDFLKVKFTNSNTPNSYNHMDA-DKLNGLWSRISHLVLPVQPENAL--KRGICL-
---------------------