Query Results 

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 787)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICTKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QVRHAHLGPSWGPDLV-----------------LLSWRGSQ--HVPGGR
AVPQ-----SGALR-PPPSLSTG-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGRGPDACMTSRASEEA--------
-------------------PAFVQLGPS-------------------LDRLHPEDRP---
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPELGRWG
EYGPRPPARLGARAGQE-------PATA-----------LGAVGTMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQIAP---VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATARSVDEPAIKRSRATSPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALELGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLCPH
FLNTPDKSPGDRLAEICSKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGAPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDSQDSMSLLFRLLTKLWICC-----------------------REEGPASEPD--EA
LVDECCLLPSQLLV--PTLDWLPVSDGLVSRLQPKQPVRLQFGK--APVLPGSTPTMQLD
--GLARIPGQPKI----DHLRRLHLGAYPTEECKACA-----------------------
---RCGCVTMLKSPNKT-AVKQWEQRWTK-NCLCGGLWRRMPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------SMDVGYVCEWDKRPRT
SHCPSIPLVCAWSCRNLI----------AFTTDQRNEEE--KDITNLIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVY
SINSG---HQEVITSLEWDQSG--SRLLSADADGRIKCWGMTDHLANSWQSLVGSEVDGD
PIVALSWLHNGVKLALHVEK--SGVSSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPNGQVLTATESLCRL--RCRVALADIAFT--GGGNIVVATCD
GSSTSPVQFYKVCVSVVSE---KCKIDTEILPSLFMRCTTDP-------ARKDKFPAVTH
LKFLARDMSEQ--V-LLCASNQCSSIAECWSL----RKEGLPLNNIFQQLSPA--VSDKQ
PMILKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLG--LALAFHDGNV
QIVHRLSLQPMAVLYGSS-LRPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGK
--LSMLRVSPSMGHSLDMSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVEKLNE
EYTRQNAALQQ--VLSTRILAMKASLCKLSQTTVTRVCDYHAKLFLISISCTLKSLLRPH
VLNTPDKSPGDRLTEICNKFTDTD--IDKVMINLKTEEFVLDMPTLQSLQQLIQWLGDFV
LYLLASLPNQ-QGSSVRPGHSFLRDGASLGTLRE------MMVMIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTRLWLCCRDES-------------------HP----CDPD--ES
LIDECCLLPSQLLI--PNMDWLPLGNGIISRLQSKLPLRLQFGK--PPVAPSYA-SVQYE
--AYTRSPTQPKI----DHLRRLHLGTFPTEPCKSCT-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWIK-TCLCGGLWRKMPHTYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSD---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1058)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRV-------PLSYP-------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKWPKS
TYCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLARMIHILDTEHPWDVH
SISSE---HSEVITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSMSPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDV-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRSLDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEAKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYMRQKPALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLMAISSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLV--PSLDWLPASDSLVSRLQPKQPLRLFFGR--APPLPGSATTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLNSPNETTAVKQWEQRWIK-NCLCGGLWRRVPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------MMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRSDD---QDLTRVIHILDTEHPWDLH
SVASE---HTEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1054)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDKFPAITH
LKFLARDMSEQ--V-LLCASSQTSSIAECWSL----RKEGLPVNNIFQQISPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNYGK
--LSMLRISPSMGHTLDVNLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQNAALQQ--VLSTRILAMKASLCRLSPCTVARVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGVLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPA--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLQFGR--APTLPGSATSLQLD
--GLVRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCAPRAGPSAIKT---APPALVF---VH
CGATAHVPPSQD------------------------------------------------
-PRIPRNMSGCL-ESWLR------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSE---HSEAITCLEWDQSG--SRLLSADADGQIKCWTMADHLANSWESPVGS

PF11635 // ENSGT00390000003821_0_Domain_1 (236, 1059)

LVEGD
PIVALSWLHNGVKLALHVEK--SAASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRRDRVPAITH
LKFLARDMSEQ--V-LLCASSQTTSVVECWSL----RKEGLPVNNIFQQLSPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQSMAVFYSSAAPRSMDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGR
--LSMLRISPSLGHALDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQKAELQQ--VLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPH
VLNTPDKSPGDRLTEICTKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--EA
LVDECCLLPSQLLI--PNLDWLPVSDGLVSRLQPKQPLRLHFGK--APTLPGSATTLQLD
--GLIRAPGQPKM----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWIK-NCLCGGLWRRLPLSY---P-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPW

PF00400 // ENSGT00390000003821_0_Domain_0 (178, 220)

DVH
SVSSE---HSEAITCLEWDQSG--SRLLSADADGQIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 237)

SMADHLANSWESHVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNVFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQSMAVFYSSATPRSADEPAIKRPRASGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPAMVQSLVEKLHE
EYTRQNAALQQV--LSTRILAMKASLCKLSPCTVARVCDYHAKLFLVAVSSTLKSLLRPH
FLNTPDKSPGDRLTEVCSKITDAD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGPSLGLLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPTSEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APPLPTSAGALPLD
--GLIRAPGQPKV----DHLRRLHLGAFPTEERKACA-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------VCDAGGTMDLAYICEWEKWPKS
THCPSVPLACTWSCRNLI----------AFTTDLRSDD---QDLTRVIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SICSG---HSEAVTCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESPVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVNE---KCRIDTEILPSLFMRCTTDL-------NRRDRLPAITH
LKFLARDMSEQ--V-LLCASSQTSSVVECWSL----RKEGLPVNNIFQQLSPA--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAIFYSSAAPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGR
--LSMLRISPSMGHSLDAGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQKAELQQ--VLSTRILAMKASLCKLSPCAVTRVCEYHAKLFLIAASSTLKSLLRPH
VLNTPDKSPGDRLTEVCAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGASLGVLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--PPALPGSATSLQLD
--GLIRAPGQPKM----DHLRRLHLGAYPTEACKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NC----------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------RKPVGAGSWG
PAEPGGRGR--GLRGQR-------PDL---------PSAGAVSGTMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRSDD---QDLTRTIHILDTEHPWDVH
SISSQ---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESCLGSM

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------SRKDKFPAITH
LKFLARDMSEQVLL---CASSPTSSLVECWSL----RKEGLPVNNIFQQISPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMVVFYSSATPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQSAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLMAVSSTLKSLLCPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPSSEPD--EA
LVDECCLLPSQLLV--PSLDWLPVSDGLVSRLQPKQPLRLYFGR--APTLPGSATTLQLD
--SLARAPGQPKM----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCLCGGLWRRTPPSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAASDPGRWG
ECGPRPPGRLGARGGQE-------PGTV-----------LGAVGMMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-APRSLDEPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------REEGAASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSTSTLQLD
--GLTRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVTQWEQRWIK-NCLCGGLWRRVPLSCS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRRIHILDTEHPWDLH

PF00400 // ENSGT00390000003821_0_Domain_0 (181, 220)

SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSLVK-D
PIVALS-LHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASETQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALV-------
--LSMLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPNMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-Q------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------APGQP

PF11635 // ENSGT00390000003821_0_Domain_3 (972, 1052)

KI----DHLRRLHLGACPTGECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NC------GPDACVTNRAAEEAPAF---VQ
LSPRSTYRPPRTPR--------------------------------SLDRAHPEDHP---
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------MMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-APRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHALEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTMARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSALRPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PSLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSTSILQLD
--GLTRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLSCS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCSIRTSVAGGMMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRSDD---QDLTRVIHILDTEHPWDLY
SIA

PF00400 // ENSGT00390000003821_0_Domain_0 (184, 220)

SE---HSEAITCLEWDQSG--SRLLSADADGQIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 237)

SMADHLANSWESTVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDKFPAITH
LKFLARDMSEQ--V-LLCASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTVGPAVHFKAMQLSWTSLALVGIDNYGK
--LSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQNAALQQ--VLSTRILAMKASLCRLSPCTVARVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPS--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APMLPGSTTTLQLD
--GLIRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCL---------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH

PF00400 // ENSGT00390000003821_0_Domain_0 (181, 220)

SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGCHQH---------LCFQWAPPLTEDGRSHMQSWLTA
TSASW------VQAVLLLQ---LQTGSCSVTRL--ECSVFLVEIGFLHVGQGGLELLTSG
DPPASASQSAGMTVSVTSSR--HVQCGHQMLPSSPRQ--PLT-------ARPGSLPGLL

PF11635 // ENSGT00390000003821_0_Domain_1 (420, 1053)

D
LLLAIKSQSAM--V-LLCASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQ--VLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPA--SEPD--EA
LVDECCLLPSQLLI--PTLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGHGPDACVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPRSLD--------------------------------HPHPEDRL---
------------------------------------------------------------
-------------------------------------------------

---MQIDLGPGNAEAAAV----------------------------------------PE
AFGKLR--RC---ARDSLVPARW-RRRSRRGAGDGLRGGPRQLGAMDLAYVCEWEKWPKN
TYCPSVPLVCAWSCRNLI----------AFTTDLRSDD---QDLTRLIHILDTEHPWD

PF00400 // ENSGT00390000003821_0_Domain_0 (179, 219)

VH
SINSE---HEEAITCLEWDQSG--SRLLSADADGQVKC

ENSGT00390000003821_0_Linker_0_1 (219, 237)

WTMADHLANSWESPVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 739)

AEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFFKVCVSVVSE---KCRIDTEILPSLFMRCTADL-------NRKDKFPAVTH
LKFLARDMSEQ--V-LLCASSQTSSVVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVADDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYS-----PADEPALKRPRAPGPAVHFKAMQLSWTSLALVGIDSHGK
--LSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQNAALQQ--VLSTRILAMKASLCKLSPCTATRVCDYHAKLLLIAVSSTLKSLLRPH
SLSTPDKSPGDRLAEVCAKITDVG--GPLARGGGTRVRAP-GEAT------------RPS
RVALARLPG--PGG------------RSAGVGRRGQARASPHVRQPQWSAP--ASLA---
--------AECPFGAPGSFCCACAE---------------------RGV---GGPT--EG
RGAP-CPHPAAGPTPRHGRRWETPGHGAASG-----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
----------------------------------------WVLGTMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SISSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWNMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1055)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQ--V-LLCASSQTSSLVECWSL----RKEGLPVNNIFQQIAPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPVSLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRSVDEPAIKRSRATGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKAALQQ--VLSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNTPDKSPGDRLAEMCAKTTDLD--IDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVFT
ATSDSQDSMSLLFRLLTKLWMCCRD---------------------EGPA--SEPD--DT
LVDECCLLPSQLLV--PTLDWLPVSDGLVSRLQPKQPVRLHFGK--APMLPCSVPTSQLD
--SLARAPGQPKI----DHLRRLHLGTYPTEECKACA-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWTK-NCLSGPDWPTGQLHP---A-----W---VT
AGGAMGLLSVTGPRSL------------------------------------PEDRKCPP
MSRAPETLKGSLVGAWQGGK----------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HHEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICTKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGRGPDACVTSRASEEAPAF---VQ
LGPQSTHHSPRTPR--------------------------------SLDHLHPEDRP---
------------------------------------------------------------
-------------------------------------------------

-----------------------------------------------------------G
GCGPRPPARQRGPRGDP-------ARPPAGEPAALAVGPVACGHAMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILASQHPVHTL
-VSGT---HLVPLPCCGLPPTG--SRLLSADADGQIKCWSMADHLANSWESHVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNVFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQSMAVFYSSAAPRAADEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPGMVQSLVEKLHE
EYTRQNAALQQV--LSTRILAMKASLCKLSPCTVARVCDYHAKLFLVAVSSTLKSLLRPH
FLNTPDKSPGDRLTEVCTKITDAD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPTSEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APTLPTSASTLQLD
--GLIRAPGQPKI----DHLRRLHLGAYPTEECKTCT-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCVCGGLWRRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HQEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--ET
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APT-------LQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGRGPGASEAPRASVQL--------
-GPRPTHHPPS-----WDP--------------------------RSLDHLHPEDQPRGL
GVQA------DPVVTWLGA----------PASVSLPRLQWMLNLDKLRLGEGRSNKRPP-
RPGLCPSRQCPGPTRDLHSVLGSLCPLGLSLNHSALTGAQRMPGPGRPQ

--------------------------------------------------MAASDPGRWG
ECGPRPPGRLGARGGQE-------PGTV-----------LGAVGMMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-APRSLDEPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGTASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSTSTLQLD
--GLTRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVTQWEQRWIK-NCLCGGLWRRVPLSCS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SISSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1057)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRSRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLC--GHGPDACVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPR--------------------------------SLDHPHPEDHLTAR
GPR-------GP---WGDPA-------RAPASVSLPLLPRALNLDKLQLGRAGPINALCA
HNLGAAPNKRPGPAHNLGVVPGSLCPLGLSLNQYLWGT-----------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 887)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVDSSGKGD
---DVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICTKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RPSPPPPPVD--RC
PCRN-------------LASWCPGL------------------------------PHVLP
--SPARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGHGPDACMTSRASEEAPAF---VQ
LGPRSTHHPPRTPR--------------------------------SLDHLHPEDHL---
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAASDPGRWG
ECGPRPPGRLGARGGQE-------PGTV-----------LGAVGMMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-APRSLDEPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGAASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSTSTLQLD
--GLTRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVTQWEQRWIK-NCLCGGLWRRVPLSCS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------RPAAGGMMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRSDD---QGAGL------LPGPWTVH
PSVEG---LR----C-HLLPTG--SRLLSADADGQIKCWSMADHLANSWESSVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDKFPAITH
LKFLARDMSEQVSL---L--CQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGK-AEE---PGAW
HCTAPECLWTLALLQSVPRPRWP---GAAPPLPAG---TQVCLTWRWS-------SPT

PF11635 // ENSGT00390000003821_0_Domain_1 (599, 1059)

RQ
--LSMLRISPSMGHTLDVNLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQNAALQQV--LSTRILAMKASLCRLSPCTVARVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGVLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICLPSTGPGLLWVLFGCQW----LLGRDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APTLPGSATSLQLD
--GLIRAPGQPRI----DHLRRLHLGAYPTEECKACA-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWRRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------RPVAGGAMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLV----------AFTTDLRNDD---QDLTRMIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WEVH
SISSE---HSEPITCLEWDQSG--SRLLSADADGQIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 237)

SMADHLANSWESPVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 652)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCHIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQ--V-LLCASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRSVDEPAVKRPRATGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPS-GHALEVHPGLRHLLFLLEYCMVTGYDWWDILLHVQPGMVRA-------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------ESVGSIMDLAYVCEWEKWPRS
ALCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SIDSE---HREAVTCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESPVGSLVDGD
PIVALSWLHNGVKLALHVEK--SGS-SFGEK------SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQ--V-LLCASSQTNSLVECWSL----RKEGLPVNNVFQQLSPM--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HVVHRLSLQTMAVFYSSAAPRSVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNHGK
--LNLLRISPSMGHSLEMGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQSASLQQ--VLSTRILAMKASLCKLSPSTVTRVCDYHAKLFLIAISNTLRSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGILRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPS--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLQFGR--APTLPGSAAASQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKTCT-----------------------
---RCGCVTMLRSPNKTTAVRQWEQRWIK-NC----------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
----------------------TAGSFLIASG-------AAMDLAYV----CEW------
DKWAKSERQRNFLCLAGLWSTLIAN----FGQAA-EGNL--DHSTLCVHGTDGQQX

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SVNSG---HVEAITCLEWDQSG--SRLLSADADGHIKCWSMTDHLANSWENTVGSMVEGD
PVVALSWLHNGVKLALHVEK--SGASNFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTSTESLCRL--RCRVALADVAFT--GGGNIVVATSD
GSSASPVQFYKVCVSVVNE---KCKIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQNNSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLG--LALAFHDGSV
HIVHRLSLQMMAVFHGSSSQRPVDEQTIKRQRTTGPLVHFKAMQLSWTSLALAGIDSHGK
--LSMLRISPSMGHVLDMNTSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHE
EYTRQSAALQQ--VLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDID--IDKVMINLKTEEFVLEMNTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGPSLGMFRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCCREEN-------------------HI----TEPD--DT
LIDECCLLPSQLLI--PNIDWLPINDGIISKLQNKQLVRLQFGK--APGLIGHTVSSQFD
--AFVRAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTMLKSPNKVTAVKQWEQRWVK-NCL---------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPELGRWG
EYGPRLPARLGARAGQE-------PATA-----------LGAVGTMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQIAP---VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSASARSVDEPAIKRSRATGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGAPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDSQDSMSLLFRLLTKLWICC-----------------------REEGPASEPD--EA
LVDECCLLPSQLLV--PTLDWLPISDGLVSRLQPKQPVRLQFGK--APALPGSTPSAQLD
--GLARLPGQPKI----DHLRRLHLGAYPTEECKACA-----------------------
---RCGCVTMLKSPNKTTEVKQWEQRWTK-NCLCGGLWRRAPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 949)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARCVCPCTGPQTHTALSSMPGPGTPPQVHTAPS-----------------------
---SMPC------------PRTPKSTWLPPPCPALGPLNPHGSFFPVPCPRTPPQ---IH
TAPSSMPC-PRTPKSTWLPPPCLALGPLNPHGSFLPVPCPGTPKSTRLRQLRPSRFPLAP
SPS-------GVLCRWHELPHTHGHQCFCSPTCFFFFFPNSLALSP-RLECSGAISAHCN
LCLLGS-NDSPASAS----------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1058)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICFPSTGPGGVQVLWGWQLLP----GRDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARHPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRV-------PLSYP-------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLRSPNRTTAVKQWEQRWIK-NCLAVEGHGPDACVTSRAAEEAPAF---VQ
LGPWPTHRPPGTPR--------------------------------CLDHPHPEDRL---
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------QAGDPRNQSRGMMDLAYVCEWEKRPKS
NHCPSIPLVCAWSCR-NLI---------AFTTDLKNEEE--KDTMM-VKVLSPVTPMIFI
HFHKVPHLLPPPISPTLASLSG--SRLLSADADGHVKCWSMTDHLANSWENTVG

PF11635 // ENSGT00390000003821_0_Domain_1 (235, 1053)

SMVEGD
PIVSLSWLHNGVKLALHVEK--SGASSFGDKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VIVSLLKPNGQVLTSTESLCRL--RCRVALADIAFT--GGGNIVVATSD
GSSTSPVQFYKVCVSVVNE---KCRIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQMNSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFCPGLG--LALAFHDGSV
HIVHRLSLQTMAMFYGSSTQRPVDEPSIKRQRTAGPSIHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHE
EYMRQNAALQQ--VLSTRIVAMKASLCKLSSCTVARVCDYHAKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPIYT
ATSDTQDSMSLLFRLLTKLWLCCRDEN-------------------HP----SEPD--ET
LIDECCLLPSQLLI--PSLDWLPISDGIISKLQSKQLVRLQFGK--APGLLGYAGAPPFE
--VLARAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTVLRSPHKATAVKQWEQRWTK-NCL---------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAQELGRWG
EYGPRPPARLGARASQE-------PATA-----------LGTVGTMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWNMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQIAPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HVVHRLSLQTMAVFYSSATPRSVDEPAIKRARAAGPSVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPAMVQSLVERLHE
EYTRQKAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNTPD-SPGDRLTEICAKITDAD--IDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLV--PTLDWLPVSDGLVSRLQPKQPVRLHFGK--APMLPGSTPTSQLD
--GLARVPGQPKI----DHLRRLHLGAYPTEGCKACA-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWTK-NCLCGGLWRKMPLSFS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HVVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--VPTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEDHGPDTCVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPR--------------------------------SLDHPHPEDRL---
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
-------------------------------------------GGMELAYVCEWEKKPKS
NHCPSIPLVCAWSCR-NSS---------PFTTDLRNEEE--KDLTHMVHIIDTEHPWD

PF00400 // ENSGT00390000003821_0_Domain_0 (179, 219)

VY
SVNSG---HTEVITCLEWDQSG--SRLLSADADGHIKC

ENSGT00390000003821_0_Linker_0_1 (219, 234)

WGMTDHLANSWENTV

PF11635 // ENSGT00390000003821_0_Domain_1 (234, 1059)

GSVVEGD
PVVALSWLHNGVKLALHVEK--SGASNFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTATESLCRL--RCRVALADVAFT--GGGNIVVATSD
GSSTSPVQFYKVCVSVVNE---KCKIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQNNSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLG--LALAFHDGSV
HIVHRLSLQMMAVFYGSSSQRPVDEPALKRPRTTGPLVHFKAMQLSWTSLALAGVDSHGK
--LSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHE
EYMRQNAALQQ--VLSTRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGASLGMFRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCCREEN-------------------HI----TEPD--DA
LIDECCLLPSQLLI--PNIDWLPINDGIISKLQNKQLVRLQFGK--APGLVGHTVSSQFD
--AFVRAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTMLKSPNKVTAVKQWEQRWIK-NCLCGGLWRKMPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPELGRWG
EYGPRPPARLGARASQE-------PATA-----------LGTVGTMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWNMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRAALADIAF--TGGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSPTSSLVECWSL----RKEGLPVNNIFQQIAPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRSVDEPAIKRSRAAGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNTPDKSPGDRLAEMCAKTTDLD--IDKVMLNLKTEEFVLDTNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDSQDSMSLLFRLLTKLWICC-----------------------REEGPASEPD--EA
LVDECCLLPSQLLV--PTLDWLPVSDGLVSRLQPKQPMRLHFGK--APTLPSNAPASQLD
--GLARVPGQPRI----DHLRRLHLGTYPTEDCKACA-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWTK-NCLCGGLWRKMPVSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSD---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1058)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICPR-----SVWVPLGWQPWPPLSAGRDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRV-------PLS---------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------MMDLAYVCEWEKRPKS
NHCPSIPLVCAWSCR-NLI---------AFTTDLKNEEE--KDLTHMIHILDTEHPWDVY

PF00400 // ENSGT00390000003821_0_Domain_0 (181, 220)

SINSE---HNEMITCLEWDQSG--SRLLSADADGHVKCW

ENSGT00390000003821_0_Linker_0_1 (220, 235)

SMSDHLANSWENTVG

PF11635 // ENSGT00390000003821_0_Domain_1 (235, 1059)

SMVEGD
PIVSLSWLHNGVKLALHVEK--SGASSFGDKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTSTESLCRL--RCRVALADIAFT--GGGNIVVATSD
GSSTSPVQFYKVCVSVVNE---KCRIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQMSSIVECWSL----RKEGLPVNNIFQQISPV--VGEKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFCPGLG--LALAFHDGSV
HIVHRLSLQTMAMFYGSSSQRPVDEQAIKRQRAAGPSIHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHE
EYMRQNAALQQ--VLSTRIVAMKASLCKLSSCTVARVCDYHAKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPIYT
ATSDTQDSMSLLFRLLTKLWLCCRDEN-------------------HP----SEPD--ET
LIDECCLLPSQLLI--PNLDWLPISDGIISKLQSKQLVRLQFGK--APGLLGYAGTPPFD
--VLARAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTVLRSPHKATAVKQWEQRWTK-NCLCGGLWRRMPASYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
-------------------------------SHDRARRACCRGGTMDLAYVCEWEKWPKS
THCPSGPLACAWSCRNLI----------AFTTDLRSDD---QDLTRMIHILDTEHPWDVH
SIPSE---HSEAITY--------------------------------------------

PF11635 // ENSGT00390000003821_0_Domain_2 (240, 313)

-
PIVALSWLHNGVKLALHVEK--SGVSSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALFYPGLGMPTGA-ASRGHGQ
GAAWGTG-AWPPASRYPERRWPCRRLAASPVL----------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------TMDLAYICEWEKWPKS
THCPSGPLACTWSCRNLI----------AFTTDLRSDD---QDLTRMIHILDTEHPWDVH
SIRSE---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWES

PF11635 // ENSGT00390000003821_0_Domain_1 (232, 1057)

PVGSVVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQLYKVCVSVVNE---KCRIDTELLPSLFMRCTTDL-------SRRDRLPAITH
LKFLARDMSEQ--V-LLCASSQTSSVVECWSL----RKEGLPVNNIFQQLSPA--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAIFYSSAAPRPVDEPALKRPRTTGPTVHFKAMQLSWTSLALVGIDNHGR
--LSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQKAELQQ--VLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPH
VLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APALPGGSSSLQLD
--GLIRVPGQPKM----DHLRRLHLGAYPTEACKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGTPVTDRASE---DT----------
------LAPQPS------------------------------------------------
-HRGSFSLEAC-------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWERWTKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWEVH
SISSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-TPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PSLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSNTSTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWIK-NCLCGGLWRRVAPLSCA-------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

MQIWRRRSGPPPGLSSAVPEGAAARREQPAGSWHGCACAVELSRL---RSTPPPVPGSSD
GFGVRV--RVGEAAEERPLPAHPAGVRLVLPQPHRLHHRPAERGGAR----CGP------
PPFPPPPLTHSPRCSRGPSAFPLPPPRPANGAGVRLSLR--ADLTHMVHIIDTEHPWDVY
SVNSG---HVEAITCLEWDQSG--SRLLSADADGHIKCWSMTDHLANSWENT

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

MGSMVEGD
PVVALSWLHNGVKLALHVEK--SGASNFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTSTESLCRL--RCRVALADVAFT--GGGNIVVATSD
GSSASPVQFYKVCVSVVNE---KCKIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQNNSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLG--LALAFHDGSV
HIVHRLSLQMMAVFHGSSSQRPVDEQTIKRQRTTGPLVHFKAMQLSWTSLALAGIDSHGK
--LSMLRISPSMGHVLDMNTSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHE
EYTRQSAALQQ--VLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPH
FLNTPDKSPGDRLTEVCSKITDID--IDKVMINLKTEEFVLEMNTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGASLGMFRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCCREES-------------------HI----TEPD--DT
LIDECCLLPSQLLI--PNIDWLPINDGIISKLQNKQLVRLQFGK--APGLIGHTVSSQFD
--AFVRAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTMLKSPNKVTAVKQWEQRWVK-NCLCGGLWRRMPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYICEWEKCPKS
NHCPSIPLVCAWSCRNLI----------AFTTDLKNEEEKVLLFVPLLLFQHPLFVWDPR
VPSSNSPYRS-RLNAREGSNSMLNPTQRRAELRGEVV-----SRTKLEWIKMEGVDF--E
NRREISWERDGWKRSTHHLE--SEFIPFSGEL-----HQIFLTPK-------LETHWKQL
AEKQSSATQAANRSVYLKSNQIVLEVI-------------IVVLRARYVPGVNMSAGICF
PPNTSQDDIFCVCQAKEA--------------------RVGLFSCRGTEEATPTKTPHSR

PF11635 // ENSGT00390000003821_0_Domain_1 (421, 663)

LQILGLDDPSQV---LLCASNQISSIVECWSL----RKEGLPVNNIFQQISPVA-VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNIDLKVANDTKFYPGLG--LALAFHDGSV
HIIHRLSLQTMAMFYGSSSQRSVDEQALKRQRTASPSVHYKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHILDMNMSLCHLLFLLEYCMVTGYDWWDILLHVQPNMVQMLVEKLHE
EYMRQNAALQQVRRPPTWGDRTRQRE----------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------MGVMDLAYVCEWEKWVKS
TYCPSLPLACAWSCRNLI----------AFTTDLRSED---QDLTHMIHILDTEHPWEVH
SISSG---HSEVITCLEWDQSG--SRLLSADADGQIKCWNMAEHLANSWESTVC

PF11635 // ENSGT00390000003821_0_Domain_1 (235, 743)

SRVDGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQ--V-LLCASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAAFYSSAAPRSLDEPALKRPRTTSPTVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGLPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQ--VLSTRILAMKASLCRLSPCTVARVWDYHTKLFLMAVTSTLKSLLRPH
FLNTPDKSPGDRLAEICAKVTDVA--ILGLHMSCPH------------------------
---IWHPYL--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLLCCPCP-------------------LPTA--SEPD--EG
LVDECCLLPSQLLV--PTLDWLPASDGLVSRLQPKQPLRLRFGR--VPTLPSSASTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNNTTAVKQWEQRWVK-NCLCGGLCAH---HRTRQEEPALQM---FC
LGVWSTCHP---------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGS

PF11635 // ENSGT00390000003821_0_Domain_2 (236, 313)

LVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLXXX--XXXXXXXXXX---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
-----------------------------------------AGGTMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRLIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SISSE---HSEAITCLEWDQSG--SRLLSADANGQIKCWSMADHLANSWESPMGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQ--V-LLCASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAIFFSSTAPRSMDEPAIKRPRTTGPTVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHTLDVNLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVERLHE
EYTRQKAALQQ--VLSTRILAMKASLCKLSPCTVTLVCDYHAKLFLIAISSTLKSLLRPH
ILNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGAPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--ET
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APILPGSATTLQLD
--GLIRATGQPKI----DHLRRLHLGAHPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWRRMPLSC---P-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------LGAMDLAYICEWEKWPKS
THCPSGPLACTWSCRNLI----------AFTTDLRSDD---QDLTRMIHILDTEHPWDV

PF00400 // ENSGT00390000003821_0_Domain_0 (180, 220)

H
SIRSE---HSEAITCLEWDQSG--SRLLSADADGQIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 234)

SMADHLANSWESPV

PF11635 // ENSGT00390000003821_0_Domain_1 (234, 1058)

GSVVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQLYKVCVSVVNE---KCRIDTELLPSLFMRCTTDL-------SRRVELPAPGS
LRYLCFPPGHH--V-LLCASSQTSSVVECWSL----RKEGLPVNNIFQQLSPA--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAIFYSSAAPRPIDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGR
--LSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQKAELQQ--VLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPH
VLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APALPGSSTGLQLD
--GLIRAPGQPKM----DHLRRLHLGAYPTEACKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWWRMPLSY---P-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKWPRS
TLCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WEVH
SIDSE---HREAITCLEWDQSG--SRLLSADADGQIKCWGMADHLANSWESPVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDRFPAITH
LKFLARDMSEQHLTNLITASSIVPSFLSCPRF----CRALVSVVSLFAPVLVS--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRSVDEPAIKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LNMLRISPSLGHTLEVSLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQSAALQQV-VLSTRILAMKASLCKLSPNTVTRVCDYHAKLFLIAISSTLRSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGILRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPTSEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLISRLQPKQPLRLHFR---APTLPGSAAASQLD
APRPARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWRRMRLAYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
-------------------------------------------GTMDLAYICEWEKWPKS
THCPSGPLACTWSCRNLI----------AFTTDLRSDD---QDLTRMIHILDTEHPWDV

PF00400 // ENSGT00390000003821_0_Domain_0 (180, 220)

H
SIRSE---HSEAITCLEWDQSG--SRLLSADADGQIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 234)

SMADHLANSWESPV

PF11635 // ENSGT00390000003821_0_Domain_1 (234, 1058)

GSVVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQLYKVCVSVVNE---KCRIDTELLPSLFMRCTTDL-------SRRDRLPAITH
LKFLARDMSEQ--V-LLCASSQTSSVVECWSL----RKEGLPVNNIFQQLSPA--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAIFYSSAAPRPVDEPALKRPRTTGPTVHFKAMQLSWTSLALVGIDNHGR
--LSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHE
EYTRQKAELQQ--VLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPH
VLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLPN--QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICCRD---------------------EGPT--SEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APALPGGSSSLQLD
--GLIRVPGQPKM----DHLRRLHLGAYPTEACKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWWRMPLSY---P-----------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKWPKS
MYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWEVH
SFNSE---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSV

PF11635 // ENSGT00390000003821_0_Domain_1 (234, 1059)

GSMVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------DRKDKFPAITH
LKFLARDMSEQVLL---CASSQTNSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSSAAPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRIAPSLGHPLEAKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNTPDKSPGDRLAETCAKITDAD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-D-QGSPLRPGHSFLRDGTSLGMLRE------LMVVTRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLV--PSLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSASALQLD
--GLARAPSQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCVCGGLWRRLPPSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
SHCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HHECT--LSWLLRG--SVCL--------------------WGSQGGSPREPE
RPL--------PPPSLPSPQ--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSTSPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAVKRLRSAGPAVHFKAMQLSWTSLALVGIDSQGK
--LSMLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLAQPTQP-GGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICFPSTGPCSV---WGPPNP---HGSLPPCPAPGPP--ES
TQLPPCPAP---GS--PKSTWLPPSMSCR----PSPPVDRRSCRNLASWCPGL--PHALP
--SPAR

PF11635 // ENSGT00390000003821_0_Domain_3 (967, 1058)

APGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
---------WCEI---

PF11635 // ENSGT00390000003821_0_Domain_3 (977, 1058)

-DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPDPGRWG
ECGPRPPGRLSARGGQE-------PGAV-----------LGAVGMMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVNSG---HSEAITCLEWDQSG--SRLLSADADGRIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPVITH
LKFLARDMSEQVLL---CASSQSSSLVECWSL----RKEGLPVNNIFQQISPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HVVHRLSLQTMAVLYSS-APRSLDEPALKRPRTTGPAIHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSSSTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPDPGRWG
ECGSRQPGRLGARSGQE-------PGTV-----------LGAVGIMELVYVCEWENWAKN
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVNSG---HSEAITCLEWDQSG--SRLLSADADGHIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
SIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASETQFYPGLG--LVLAFQDGSV
QMVHRLSLQTMAAFYSS-TPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGTLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PSLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSNTSTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWIK-NCLCGGLWRRVPLSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKRPKS
NHCPSIPLVCAWSCRNLI----------AFTTDLKNEEEKGIDLTHMIHILDTEHPWDV

PF00400 // ENSGT00390000003821_0_Domain_0 (180, 220)

Y
SINSG---HIEIITCLEWDQSGIGSRLLSADADGHIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 235)

SMTDHLANSWENTVG

PF11635 // ENSGT00390000003821_0_Domain_1 (235, 864)

SMVEGD
PIVALSWLHNGVKLALHVEKVQSGASNFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTSTESLCRL--RCRVALADIAFT--GGGNIVVATSD
GSSTSPVQFYKVCVSVVNE---KCKIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQVKV-LLCASNQNSSIVECWSL----RKEGLPVNNIFQQISPVGEVGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGTGLALAFHDGSV
HIVHRLSLQTMAVFYGSSSQRPVDEQAIKRQRAAGPLVHFKAMQLSWTSLALVGIDNHGK
VQLSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHE
EYMRQNAALQQVQVLSTRIVAMKASLCKLSSSTVARVCDYHAKLFLIAISCTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDIGTDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFV
LYLLASLPNQVQGSPVRPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCCKGLK-------------------LPRIPATRPLWVQG
TLLAGCRKPPQGQRGS----------G---------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------L

PF11635 // ENSGT00390000003821_0_Domain_3 (981, 1059)

RRLHLGAYPTEECKACT-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGIMDLAYVCEWERWIKS
THCPSVPLACAWSCRNLI----------AFTMDLRGDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTGSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDDGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSATTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVRQWEQRWIK-NCLAVEGRGPGASVTNRSSEEAPVFLDCSQ
PTHRPPGTPRS-----LDR--------------------------LSLDRLHPEDQP---
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPDPGRWG
ECGSRQPGRLGARSGQE-------PGTV-----------LGAVGIMELVYVCEWENWAKN
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVNSG---HSEAITCLEWDQSG--SRLLSADADGHIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
SIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASETQFYPGLG--LVLAFQDGSV
QMVHRLSLQTMAAFYSS-TPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGTLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PSLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSNTSTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKATAVKQWEQRWIK-NCLCGGLWRRVPLSCP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
--------------------------------------------TMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SVNSE---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESHVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTADL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNVFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGR-LALAFHDGSV
HIVHRLSLQSMAVFYSSAAPRSADEPAVKRSRTTGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHTLDVSLALRHLLFLLEYCMVTGYDWWDTLLHVQPGMVQSLVEKLHE
EYTRQNAALQQV--LSTRILAMKASLCKLSPCTV---GDYHAKLFLVAVSSTLKSLLRPH
FLNTPDKSPGDRLTEVCAKITDAD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGASLGTLRE------LMVVIRIWGLLKPSCLPVYS
ATSDTQDSMSLLFRLLTKLWTCC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPVSDGLVSRLQPKQPLRLHFGK--APALPASASALQLD
--GLIRAPGQPKI----DHLRRLHLGAYPTEECKTCT-----------------------
---RCGCVTMLRSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLSYP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------------------MDLAYVCEWEKKPKS
NHCPSIPLVCAWSCR-NLI---------AFTTDLRNEEE--KDLTHMVHIIDTEHPWD

PF00400 // ENSGT00390000003821_0_Domain_0 (179, 220)

VY
SVNSG---HTEVITCLEWDQSG--SRLLSADADGHIKCW

ENSGT00390000003821_0_Linker_0_1 (220, 234)

SMTDHLANSWENTV

PF11635 // ENSGT00390000003821_0_Domain_1 (234, 1059)

GSVVEGD
PVVALSWLHNGVKLALHVEK--SGASNFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TISGL------VTVSLLKPNGQVLTATESLCRL--RCRVALADVAFT--GGGNIVVATSD
GSSTSPVQFYKVCVSVVNE---KCKIDTEILPSLFMRCTTDP-------ARKDKYPAITH
LKFLARDMSEQ--V-LLCASNQNNSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLG--LALAFHDGSV
HIVHRLSLQMMAVFYGSSSQRPVDEPALKRPRTAGPLVHFKAMQLSWTSLALAGVDSHGK
--LSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHE
EYMRQNAALQQ--VLSTRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPH
FLNTPDKSPGDRLTEICSKITDVD--IDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFV
LYLLASLPNQ--GSPVRPGHSFLRDGASLGMFRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWLCCREEN-------------------HI----TEPD--DA
LIDECCLLPSQLLI--PNIDWLPINDGIISKLQNKQLVRLQFGK--APGLVGHTVSSQFD
--AFVRAPGQPKI----DHLRRLHLGAYPTEECKSCT-----------------------
---RCGCVTMLKSPNKVTAVKQWEQRWIK-NCLCGGLWRKMPLSYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------LP-QGSPV

PF11635 // ENSGT00390000003821_0_Domain_1 (797, 1059)

RPGHSFLRDGASLGMLRE------LMVVIRIWGLLKPSCLPIYT
ATSDTQDSMSLLFRLLTKLWLCCKKEACQSLMVPIWQRPDSLPNTGRDENHPSEPD--ET
LIDECCLLPSQLLI--PNLDWLPVSDGIVNKLQGKQLLRLQFGK--PPGLLGYPVTPQFD
--LFARGPGQPKI----DHLRRLHLGAYPTEECKSCTRTKEFQARGRMWARGHMWGRESS
CIRRCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWRRVP------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--VPTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEDHGPDTCVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPR--------------------------------SLDHPHPEDRL---
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSD---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1058)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICPC-----SVWVPLGWQPLP----GRDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLCGGLWWRV-------PLSYP-------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1057)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--GESPG
R--LRE--ALVTRQLKRATAVP----------------SPRPHSFPRG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLC--GHGPDACVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPR--------------------------------SLDHPHPEDHLTAR
GPR-------GP---WGDPA-------RAPASVFLPLLPRALNLDKLQLGRAGPINALCA
HNLGAAPNKRPGPAHNLGVVPGSLCPLGLSLNQYLWGT-----------

------------------------------------------------------------
---------------------------------MCDLRRPAAGGMMDLAYVCEWEKWSKS
THCPSVPLACAWSCRNLI----------AFTMDLRSDD---QDLTRMIHILDTEHPWDLH
SIPSE---HREAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESSVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1053)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDL-------NRKDKFPAITH
LKFLARDMSEQVLL---CASSQTSSIVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGK
--LSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHE
EYTRQTAALQQV--LSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPH
FLNTPDKSPGDRLTEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSLLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLI--PSLDWLPASDGLVSRLQPKQPLRLQFGR--APTLPGSAATLQLD
--GLARAPGQPKI----DHLRRLHLGACPTEECKACT-----------------------
---RCGCVTMLKSPNRTTAVKQWEQRWIK-NCLAVEGHGPDACVTSRAAEEAPAF---VQ
LGPWPTYRPPRTPR--------------------------------SLDHPHPGDRL---
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
------------------------------------EGPPVAGGTMDLAYVCEW-KWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRLIHILDTEHP

PF00400 // ENSGT00390000003821_0_Domain_0 (177, 220)

WDVH
SINSE---HSEAITCLEWDQSG--SRLLSADANGQIKCWSMADHLANSWESPVGSLVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAFT--GGGNIVVATAD
GSSASPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTADP-------NRKDRFPAITH
LKFLARDMSEQ--V-LLCASSQTSSSVECWSL----RKEGLPVNNVFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSAAPRSADEPAIKRPRTTSPAVHFKAMQLSWTSLALVGIDSHGK
--LSVLRISPSMGHPLDLSLALRHLLFLLEYCMVTGYDWWDILLHVQPAMVQSLVDRLHE
EYTRQTAALQQ--VLSTRILAMKASLCKLSPCTATRVCDYHAKLFLTAVSSTLKSLLRPH
ILNTPDKSPGDRLAEICAKVTDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX------XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXX---------------------XXXX--XXXX--XX
XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXX
--XXXXAPGQPKI----DHLRRLHLGAHPTEECKACT-----------------------
---RCGCLTMLRSPNKTTAVRQWEQRWIK-NCLAVSRGQVPVTSQ---AAEEDMA-----
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

MQI-----NPEVELC--------RSRRHPI---SVCEAPEQLRRLLGLEKMAAPELGRWG
EYGPRPPARLGARAGQE-------PATA-----------LGAVGTMDLAYVCEWERWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_1 (237, 1059)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVATAD
GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQIAP---VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATARSVDEPAIKRSRATSPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSMGHALELGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKAALQQV--LSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLCPH
FLNTPDKSPGDRLAEICSKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGAPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDSQDSMSLLFRLLTKLWICC-----------------------REEGPASEPD--EA
LVDECCLLPSQLLV--PPLDWLPVSDGLVSRLQPKQPVRLQFGK--APVLPGSTPTMQLD
--GLARIPGQPKI----DHLRRLHLGAYPTEECKACA-----------------------
---RCGCVTMLKSPNKT-AVKQWEQRWTK-NCLCGGLWRRMPLNYS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAASDPGRWG
ECGPRPPGRLGARGGQE-------PGTV-----------LGAVGMMDLAYVCEWEKWAKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDLTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCHIDTEILPSLFMRCTTDP-------NRKDRCPAITH
LKFLARDMSEQVLL---CASSQTSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVFYSS-APRSLDEPALKRPRTTCPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLVSLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGTASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSTSTLQLD
--GLTRAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVTQWEQRWIK-NCLCGGLWRRVPLSCS--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

------------------------------------------------------------
----------------------------------EPATALGTVGTMDLAYVCEWEKWPKS
THCPSVPLACAWSCRNLI----------AFTTDLRNDD---QDLTRMIHILDTEHPWDVH
SINSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWNMVDHLANSWESRVGSL

PF11635 // ENSGT00390000003821_0_Domain_2 (237, 293)

VEGD
PIVALSWLHNGVKLALHVEK--SGASSFSEKF-----SRVKFSPSLTLFGGK

ENSGT00390000003821_0_Linker_2_1 (293, 361)

PXXXXXXX
XXXXX------XXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX--XXXXXXXXXXXD

PF11635 // ENSGT00390000003821_0_Domain_1 (361, 562)

GSSALPVQFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------HRKDRFPAITH
LKFLARDMSEQVLL---CASSQTSSLVGCGSL----RKGGLPVNNIFQQIAPA--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFHDGSV
HIVHRLSLQTMAVFYSSATPRSVDEPAIKRARAAGRRVSGLLAV----------------
-------FSPHMRPHVSS----------RQCCTHR-------------------AGRCPR
PPAPPLCPLP-Q-VLSTRILAMKASLCRLSPCTVTRVCDYHTKLFLVAISSTLKSLLRPH
FLNT----PGDRLTEICAKITDAD--IDKVMINLKTEEFVLDTNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EA
LVDECCLLPSQLLV--PTLDWLPVSDGLVSRLQPKQPVRLHFGK--APMLPGSTPTSQLD
--GLARVPGQPKI----DHLRRLHLGAYPTEGCKACM-----------------------
---PLSFS----------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------

--------------------------------------------------MAAPDSGRWG
ECGPRPPGRLGVRGAQE-------PGTV-----------LGAVGMMDLAYVCEWEKWTKS
TYCPSLPLACAWSCRNLI----------AFTTDLRNDD---QDMTHMIHILDTEHPWEVH
SVSSG---HSEAITCLEWDQSG--SRLLSADADGQIKCWSMADHLANSWESS

PF11635 // ENSGT00390000003821_0_Domain_1 (233, 1059)

VGSQVEGD
PIVALSWLHNGVKLALHVEK--SGASSFGEKF-----SRVKFSPSLTLFGGKPMEGWIAV
TVSGL------VTVSLLKPSGQVLTSTESLCRL--RGRVALADIAF--TGGGNIVVAAAD
GSSASPVKFYKVCVSVVSE---KCRIDTEILPSLFMRCTTDP-------NRKDRFPAITH
LKFLARDMSEQVLL---CASSQSSSLVECWSL----RKEGLPVNNIFQQISPV--VGDKQ
PMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLG--LALAFQDGSV
HMVHRLSLQTMAVLYSS-APRSLDEPALKRPRTAGPAVHFKAMQLSWTSLALVGIDNHGK
--LSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHE
EYTRQKPALQQV--LSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPH
FLNTPDKSPGDRLAEICAKITDVD--IDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFV
LYLLASLP-N-QGSPLRPGHSFLRDGTSLGMLRE------LMVVIRIWGLLKPSCLPVYT
ATSDTQDSMSLLFRLLTKLWICC-----------------------RDEGPASEPD--EG
LVDECCLLPSQLLV--PNLDWLPASDGLVSRLQPKQPLRLRFGR--APTLPSSASTLQLD
--GLARAPGQPKI----DHLRRLHLGAYPTEECKACT-----------------------
---RCGCVTMLKSPNKTTAVKQWEQRWIK-NCLCGGLWRRVPLARP--------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------