Query Results 

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------------------------------------------RQ-MHCSGLAWHPVA--T
QVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 309)

I
LCCNPNTG

PF00400 // ENSGT00390000003175_1_Domain_3 (309, 347)

EMLYELPTHTQWCFDIQWCPRNPAVLSAASFDGHISIYSIMGGSTDGLRQKQ
ADKLSSSF-S-LDPF-TGQPLP-PQ-LPQQTSP-S-TLL--PLKPKWI-RPLGASFSFGG
KLVTFENLKLQQHQGVEQQQQQQQQHHVYISQVVTEKEFLSRSNQLQQAVQTLGFVSYCQ
KKIESSQTDFEKNVWSFL-KVNFEDDC-RHKYLELLGYR-KGDLGQKIAVDKE-------
----DASVESHKDSEQNDGEDSLPMEEQS----C---REREKETESPPVAE-GTFSISIN
EDLDGLITQALLTGNFESAVDLCLRDNRMADAIILAIAGGQELLAQTQEKYFARTQSKMT
RV----------------------------------------------------------
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------------------------------

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSN-----------------
-----------------------------------RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGE---------------------------------------------------
---------------------------------------------------------FGG
KLVTFENVRMPSHQGAEQQ--Q-QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPVAGHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNTYPN------TPYISSA-SSYTGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLVLKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNISGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPLE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHNNR-MHCSGLAWHPEVATQ
MVLASEDDRLPVVQVWDLRFASTPLRVLENHA--RRGILAIAWSMADPELLLSCGKDAKI
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
ADKLSSSF-GNLDPFGTGQPLP-PLQIPQQAAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKVQSQQGA--E-L---QQHVFISQVVTEKEFLSRSDQLQQVVQSQGFVNYCQ
KKIDASQSDFEKHVWSFLK-VNFEDDS-RGKYLQLLGYS-KEDLGKKIALALNKVDGP--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKQESEFLPSAG-GPFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGNNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPESTNQPNIVQLRDRLRRAQGEPVPGQES-PQVPYE
RQQLPKGRP-GPIADQTQIPR-VPTQQYYPH-----------------------------
--GENPPPPGFLMHGNVNP-----NVAAAQLSTSPGH--MHTQVPPY-PQPQPYQPVQQY
SFGTGGSA----TYRPQQPAA---PSASNAYPN------TPYIPSA-PSYSGQSQLYAAQ
HQVSPPTSSPTASLPP-LPSSGASFQHGGPGAPPS-SAYAL-PPGTTGTLPAASELPASQ
RTENQSVQDQ--AN--M-LEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PMGDPQSQML----QQPSAPGPLSNQPSFPQPHLSGGQPS----FHGLQQPLGQPGMP-P
SFSKPNIEGAPGGPIGNTIQHVQALPAEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDANKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTATQAWSPAQCHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHTMDSKGNLSGVLIAGGENGNIILYDPSRIIAGD
S

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

DVVIAQNDKHTGPVRALDVNVFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA--XXXXX-XXXXXXXXXLLLSCGKDAKI
LCCNPNSGEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX--XXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFGG
KLVTFENVKPQ--LGA--EQQL-QRPQVHISQVVTEKEFLLRSDYLQQVVQSQGFVSYCQ
KKIDASQTDFEKSVWSFLK-XXXXXXX-XXXXLELLGYR-KEDLGKKIALSLKKGAGP--
----ELALKDSDHLAPSDGQESHAAEENFFGEST---KEENRETEISPSVS-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKTQSKIT
RXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLGTRLENEGDPLLQT
QACLCYICAGNIEKLVACWTKAQDGSSPLSLQXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPNIVQLRDRLRRAQGEPGSEQEAASRAVYE
RQHMAKGGP-GPAVSQTQGPR-TPAQQYYPH-----------------------------
--GENPPPPGFIMPGPSNP-----NMA-IPQSTSSGH--MYAQVPSY-PQPQTYQPTQQY
TFGTGGPA----MYQPQQPAP---LPASNAYPN------PPYVPSA-SSHSGQSPIYAAQ
HQASPNSPSSMSAFPP-P-PSGASFQHGGPGAPPSSTAYVL-PPGPTGTLPATSELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKIP--ENFTPPVPITSPIMN
PLGDPQSQMQQQQPQQPSVPAPLSGPAPFQQPHLSGSQPILQNPFHGMQPPLQP--AIPT
PFSKPSTEGAPGAPIGNTIQHVQSLPTEKITKKPIPAEHLVLKTAFEELIQRCLASATDP
QTKRKLDDANKRLEFLYDKLREQTLSPTILNGLHNIARSIETRNYMEGLNIHTHVVSNSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGKKFQVTPLTLLLFK----------
-----RLLVIKFIFFY-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGE
KDVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDRLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ-Q-QHHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKVNFW-ETLNVV--
----DCALKDSDQVAQSDGEASPAAEEQLLGEVL---I-------FFPYYI-GQ------
IHIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVVLRKAVQLTQATDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPMAGH-ESPKIPYE
KQQVPKGRP-GSVAGHHQMPR-VQAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAGSPSD
TQGENPPPPGFLMHGNVNP-----NAA-SQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPA-TFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMVQQ---QLSAPVPLSSQSSFPQPHLPGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTRRKLDDASKRLELLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

------------------------------------------------------------
------------------YHKLIWGPHKMDSKGNASGVLIAGGENGNIIVYDPAKIISGD
KEVVIAQKKKHTGPVRAXXXXXXX-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRSPVVQMWDLRFASSPLRVLENHAXXXXXXXXXXXXXX---XXXXXXXXXXX
XXXXXXX

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

XXVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGHISVYSLMGGSSDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPRWIRRPVGASFSXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X--XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXVNFEDDS-RGKYLELLGYK-KEDLGKKXXXXXXXXXXXXX
XXXXXX---------XXXXXXXXXXXXXXXXXXXXRIKKEKQDSEFLPLP-GGTFNISIS
GDVDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCHLKNWKEALAAVLTYAKPDEFSTLCDLLGSRLESEGDSLLQT
QAYLCYICAGNVEKLVACWNKAQDGSNPLSLQDLIEKGVILRKAVQLTKTMXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPNIVQLRDRLCRAQGEPAPGQES-PKIPYE
KQQLPKGRT-GPIAGHPQMPR-TSAQQYYPHXXXXXXXXXXXXXXXXXX-----------
---------------------------XXXXXXXXXX--XXXXXXXXXXXXXXYQPAQQY
PFGTGGSA----MYRPQQPVA---PPASNAYPN------TPYISPA-SSYSGQSQLYTAQ
HQSSPPTSSPSASFPP-PPSSGASFQHGGPGAPPSSSAFAL-PSGTTGTLPAASELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKVP--ENFMPPVPITSPIMN
PLGDAQSQMLQ---QQPSTPVPLPSQASFPQPHLPGGQP-----FHGIQQPIGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFENLIQRCFSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPAIISGLHNIARSIETRNYSEGLNTHTHIVSTSN
FSEISAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTATQAWSPAQCHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNLSGVLIAGGENGHVILYDPSRIIAGD
SDVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNVFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCCNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAILSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTPP-QGVVLPLKKPPKWIRRPVGASFSFGG
KLVTFESMKPQP--GA--EQQL-QRHQVHISQVVTEKEFLLRSDYLQQVVQSQGFVSYCQ
KKIDASQTDFEKNVWSFLK-VNFEDDS-RGKYLELLGYR-KEDLGKKIALALKKGEGP--
----ELVLKDSDQLAPSDGQESHAAEENFFGEIT---KEENQETEISLSS-GGTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKTQSKIT
RLITAVVMKNWKEIVQSCDLKNWREALAAVLTYARPDEFSALCDLLGTRLENEGDALLQT
QACLCYICAGNIEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQASDANVIGALL
AEKMSQYANLLAAQGSIAAALAFLPANTSQPNIVQLRDRLLKVVERRIEYQRRG-YGSVV
SKDLVKLKP-ACLCRSTQLVR-VKSQPSLIQVRIAPTVTTWSNKTPTALLSHPPAASPSD
TQGENPPPPGFIMPGPSNP-----NMA-ISQPTSPGH--MYAQVSSY-PQPQKYQQTQQY
TFGTGGPA----MYQPQQPVP---LPASNAYPN------PPYMPSA-SSHSGQSPIFAAQ
HQASPNTPNSMSAFPP-P-PSGASFQHGGPGAPPSSTAYVL-PPGSTGTLPATSELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKIP--ENFTPPVPITSPIMN
PLGDPQSQMQQQ--QQSSVPAPLSGQVPFQQPHLSGNQPILQNPFHGMQQPLQS--TIPP
AFSKPSTEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEELIQRCLASATDP
QTKRKLDDANKRLEFLYDKLREQTLSPTILSGLHNIARSIETRNYLEGLNIHTHVVSNSN
FSETSAF-------MPVLKVVLTQANKLGV

------------------------------------TSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGEVSGVLIAGGENGNIILYDPSKIIAGD
KEV----------------------TNLVASGANESEICIWDLNNFSAPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

VSCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKTEPIIKVSDHSNR-MHCSGLAWHPEIATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDTLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQSAQ-HSVVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRVQSPQGAEQQL---QQQQVFISQVVTEKEFLSRSDQLQQVVQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLRKKIALALNKVDGT--
----DVALTDSGPGAQSDGEESPAAEEQLLAERI---KEETQESEFLPSAG-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGKELLARTQTKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLQT
QACLCYICAGNVEKLVSCWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQAMDTNSVGVLL
AEKMSQYANLLAAQGSITA-AAFLPDNTNQPNIVQLRDRLRRAQGEPVSVQ-ESAKVPYE
RQPMPKGRP-GPIAGHPQMPR-MQVQQYYPH-----------------------------
--GENPPPPGFIMHGNINP-----NAA-APLPTSTGH--VHGQVPPY-PQPQPYQPAQQY
PFGTGGSA----LYRPQQPVA---PPASNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPAASLPP-PPSSGASFQHGGPGAPPSSAAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFTPPVPITSPIMN
PLGDPQSQMLQQ--Q-TPAPVPPSNQASFPQPHLPGGQP-----FHGMQQPLGQASMP-P
SFSKPNLEGAPGALIGNTVQHVQSLPTEKITKKPIPDEHLILKTTFEELIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIEMRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMNSKGNVSGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHNNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVVQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

TSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKILSQQGAEQQ--Q-HHHQVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIEASQTEFEKNVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIALALNKMDGP--
----DVALKDSDQVAQSDGEESPAAEEQLLGERI---KEEKQESEFLPSAA-GTFNISIS
EDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLNNWREALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQTMDANTVGVLL
AEKMSQYASLLAAQGSIAAALAFLPENTNQANIVQLRDRLCRAQAEPIPRH-ETPKIPYE
RHQLPKGRP-GPAVGHTQMPR-VPAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NTA-AQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----MYRPQQPVA---PPASNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASPPTSSPAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPDASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSNQASFPQPHLSGGQP-----FHGIQQPLAQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPAIINGLHNIARSIETRNYPEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XYHKLIWGPHKMDSKGNVSGVLIAGGENGNIILYDPSKIIAGD
KE

PF00400 // ENSGT00390000003175_1_Domain_0 (123, 162)

VMIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGVLAVAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 309)

I
LCSNPHTG

PF00400 // ENSGT00390000003175_1_Domain_3 (309, 347)

EVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDELRQKQ
VDKLSSSF-GNLDPFGTGQVLP-PLQIPQQSAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKVLSQQGAEQLQ----HHPVFISQVVTEKEFLSRSDQLQQVVQSQGFVTYCQ
KKIEASQTEFEKNVWSFLKXXXXXXXXXXX---XXXXXXXXXXXXXXIALALNEVDGP--
----DVALKDSDQVAQSDGEESPAAEEQLLGERI---KEEKQESEFLPSAG-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVME------IESCDLK--REALAAVLTYA-PDEF-SLCDHLGARLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGNNPLSLQXXXXXXXXXXXXXXXXXPVDTNTVGVLL
AEKMSQYASLLAAQGSIAAALAFLPENTNQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XX-XXX---------------------------------XXXXXXXXXXXXXXXXXXXXY
PHGENPPPPGFIMPGSVNP-----SAV-PQLPTSPGH--MHTQVPPY-PQPQPYQPTQQY
SFGTGGSA----VYRPPQPVA---PPASNAYPN------TPYISSA-PSYSGQSQLYAAQ
HQASPPSSSPAAAFPP-PPPSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPDASELPASQ
RT------------------GPQNGWNDPPALNRGPKK-KKMP--ENFMPPVPITSPIMN
PLGDSQSQMLQQ---QPSAPVPLSNQAALTQPHLPGGQP-----LHGIQQPLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
QTKRKLDDASKRLEFLYDKLRDQTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX-------XXXXXXXXXXXNKLGV

---------MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQKDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAVAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSIDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQSAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFESVAVPLQQGA--E-QQ-RRQPVFISQVVTEKDFLNRSAQLQHAVQSQGFIGYCQ
KKIEASQTEFEKNVWSFLK-VNFEEDS-RGKYLELLGYR-KEDLGQK-------------
--------------------------------RI---KEEKQECDFLPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 741)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCELLGSRLEREGDSLLRT
QACLCYICAGSVERLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQALDTNTVGALL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGKPVSGQES-SQSPYE
RQPLSKGRP-GPVAGHSQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMQGNVIP-----NPA-APLPTAPGH--MPSQLPPY-PQPQPYQPAQQY
SFGTGGAA----VYRPQQPVA---PPASNAYPN------TPYISPV-ASYSGQPQMYTAQ
QASSP-TSSS-AASFP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTPPAASELPASQ
RTENQSFQDQ--AS--I-LEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PSGDPQSQGLQ---QQPSTPGPLSSHASFPQQHLAGGQP-----FHGVQQPLAQTGMP-P
SFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPEEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLSVHTHIVSTSN
FSETSAF-------MPVLKVVLSQASKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATAHCSA--------------------
------IGFILFIFSC-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ---QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----DVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPV-GHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPSTSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPIPLSSQSSFPQPHLSGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHSIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSQGNVSGVLIAGGENGNTILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLTCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSVVLPLKKPPKWIRRPVGASFSFGG
KLVTFASVRAQPPQGAEPQQ-P-QQHHVLISQVVTEQEFLKRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGP--
----DVRI-----------------------------KEEKQESEFLPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGDFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKDWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRRAVQLTQAVDTNAVGVLL
AEKMSQYASLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGDPAPGHQESPKSPYE
RQQLPKGRP-GPVAGHTQMPR-VPAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPAFVMHGSGHP-----NAG---APTPLGH--VHTQVPPY-PQPQPYQPAQQY
SLGTGGSA----VYRPQQPVA---PSASNTYPN------TPYISSA-SSYPGQSQLYTAQ
HQASPPTSSPTASFPL-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RTESQSMPD-----QASVLEGPQNGWNDPPALNRVPKK-KKMP--ENFTPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQASFLQPHLPGGQP-----FHGILQPLGQVGMP-P
SFSKPNVEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLVLKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIISGLHNIARSIETRNYSKGLTIHTHVVSTSN
FSETSAF-------MPVLKVVLTQAIKLGV

---------MKLKEVDRTAMQAWSPAGQHPIYLATGTSAQQLDATFSTSASLEIFELDLA
DPSLDMKSCATFSSSH-RYHKLIWGPHSMTTGERVSGVLIAGGENGNVILYDPAKIIAGD
T

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVIIAQKDKHTGPVRALDVNMFQ-TNLVASGANESEIYIWDLNNFATPMTPGVKTQPLE
DISCMAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHNNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLESHT---RGILAIAWSMADSELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDQLSSSF-GNLDPFGTGQPLP-PLQLPQQTAP-QSVVLPLKKPPKWIRRPVGASFSFGG
KLVTFENAKPQQQPGI--EQQQ-QRHHVYVSQVVTEKEFLARSNQLQEAVQSEGFISYCQ
KKIDMAQADFEKNVWAFLK-VNFEEDS-RAKYLELLGYR-KDDLRNKITSALNKEGR--A
DGELGEAPAESDASLPNERDEGQAAEEPFLGERV---KDNKQETEDVGSA-KKTFNISVS
GDVDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLSRTQEKYFVKMQSKIT
RLITAVVTKNWKEIVQSCDLQNWREALAAVLTYARPDEFAALCDLLGNRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGNSPLSLQDLIEKVVILRKAVQLTQAVDPNAVGALL
AEKMSQYANLLAAQGSIAAALTFLPASTNQPNIVLLRDRLCRAQGELPARQEA-VKAPYD
RQPMPKGRA-GAVAGQMQGPQ-APAQQYYQQ-----------------------------
--GDNPPPPGFIMPGAVNP-----SAP-------QPA--MYSQAGARPAYPQSDNWG---
YWGQPAPSLALGGFRPSRP---------------------------DAFCPPPPPLSPGQ
PQPSPTGPNPASSFPL--PPSGASFQHGRPGLPATSVAYAL-PTGPTGTLPAASDLPASQ
RTENLPAPDQASPL--A-VPGPQNGWNDPPALNRAAKK-KKASRESDFVPELLITALILT
VAGQNNWGWLAQSRE-----SLFIPWCCFYLAHLPSSQHHL--------QVLLGSWVVPP
AASKPSTEGAPGAPIGNTIQHVQALPTEKITKKPIPEEHLILKTTFEALIQRCLLSASDP
QTKRKLDDANKRLECLYDKLREQTLSPTIISGLHNMVKSIETRNYVEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQ--Q-QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPVAGHHQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYTGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQP-----FHGVQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ-Q-QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPVAGHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYTGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQP-----FHGVQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXTNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-XXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXX

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

XXVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSLSF-CNLDPFTGXXXXX-XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXFGG
KLVTFENVKAQSQQGADQQ------QQVFISQVVTEKEFLLRSDQLQQVVQSHGFISYCQ
KKIDTSQTEFEKNVWSFL-KVNFEDDS-RGRYLELLGYR-KEDLGKKIALALNKVYGA--
----DMALKDSDHVAQSDGEESPAAEEQLLGEXX---XXXXXXXXXXXXXX-XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLLGTRLESEGDSILQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDANSVGVLL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPDIVQLRDRLCRAQGEPGPGP-ESTKIPYE
RQQLPKGRP-GPVAGHPQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFLMHGNVNP-----NAA-AQPPTSPGH--VHTQVPPY-PQPQLYQQAQQY
SFGSGGSA----MYRPQQPVA---PPASTAYPN------TPYIPPS-SSYSGQSQLYPAQ
HQTSPT-SSSAASLPP-PPPPGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDTQSQMLQQ---QPSAPGPLPSQASFPQPHLPGVQP-----FHGIQQPLAQTGMP-P
PFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLLSATDP
XXXXXXXXXXXXXXXXXX--XXXXXXLSTITNLHNIARSIETHY----SEIHTHIVSTSN
FSETSAF-------M---------------

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DSSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KDVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFSTPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ-Q-QHHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGT--
----SVALKDSDQVAQSDGEASPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 800)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDRSHPLSLQDLIEKVVVLRKAVQLTQATDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPMAGH-ESPKIPYE
KQQLPKGRP-GSVTGHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFLMHGNVNP-----NIA-SQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPA-TFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTRRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTATQAWSPAQCHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNLSGVLIAGGENGNVILYDPSRIIAGD
SDVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNVFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGVLAIAWSMADPELLLSCGKDGK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCCNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQLPQQTPLQGVVVLPLKKPPKWIRRPVGASFSFGG
KLVTFENTKPQP--GT--EQQP-QHHQVYISQVVTEKEFLLRSDHLQQVVQSQGFVSYCQ
KKIEASQTDFEKNVWSFLK-VNFEEDS-RGKYLELLGYR-KEDLGKKIAVALKKGEGP--
----ELVLKESNPMAPNDVQESHAAEENFFGESI---KEENRETEISLSA-GGTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKTQSKIT
RLITAVVMKNWKEIVQSCDLKNWREALAAVLTYARPDEFSALCDLLGTRLEKEGDSLLQT
QACLCYICAGNIEKLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQVTQATDTNAIGALL
AEKMSQYASLLAAQGSIAAALAFLPANTSQPNIVQLRDRLRRAQGESMPEQEATSRALYD
RQHMSKGGP-GPAVGQTQVPR-APAQQYYPH-----------------------------
--GENPPPPGFIMPGPSNP-----NMA-VQPPTSSGH--MYAQVPSY-PQPQPYQPTQQY
SFGTGGPA----MYQPQQPSP---LPASNAYPN------PPYIPSSASSHSGQAPLYAAQ
HQASPNTPSPMSAFPP-P-PSGAPFQHGGPGAPPSSTAYGL-PPGSTGTLPATSELPASQ
RTENQSNQDQ--AS--M-LEGPQNGWNDPPALNRVPKK-KKIP--DNFTPPVPITSPIMN
PLGDPQSQMQQQ--QQPSVPAPLSGQAPFPQPHLSGSQPVLQNPFHGIQQPLQP-A-IPP
AFSKPNMEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEELIQRCLASATDP
QTKRKLDDANKRLEFLYDKLREQTLSPTILNGLHNIARSIETRNYLEGLNIHTHVVSNSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKTDSKGEVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNEKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVVQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQATP-RSPGLPLKKPPKWIRRPVGASFSFGG
KLVTFENIRIQPLQGA--EQQ--QQYHVFVSQVVTEKEFLRRSDQLQQVVQSQGFISYCQ
KKIDASQTEFEKNVWSFLK-VNFEDNS-RGKYLELLGYR-KEDLGKKIALTLNKVDGA--
----DVALRDSDQGAQSDGEESPAAEEQLLGEHI---KEEKQESEFLPPAA-GTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 740)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDANTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRERLCRAQGEPMPGHES-PKTPYE
KQQLPKGRP-GPVAGHPQMPR-VHTQQYYPQVRIAPTVTTWSNKTPTALPSHPPAACPSD
TQGENPPPPGFLLRENVTP-----STA-AQQPTPPGH--MHTQGLPY-PQPQPYQPAQQY
SFGAGGSA----AYRPQQPVA---PP-SSAYPN------NPYLSPA-SSYPGQSQLYAAQ
HQASLPAPSPTASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAGSELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKMP--ENFMPPIPITAPIMN
LLGDPQSQMLQ---QQPSAPAPPSSQPSLPQPHLPGGQP-----FHSIQQPLG-PAVP-P
PFSKPNIEGAPGAPIGNTFQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEVLYDKLREQTLSPTIASGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQAKKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNVSGVLIAGGENGNIILYDPSKIIAGE
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVVQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFANVRPQPQQGVEPQ--A-LQNHVFISQVVTEKEFLRRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIALALNKVDGP--
----DVALKDSDQVAQSDGEESPAAEEQLLGERT---EEEKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGNFENAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAVDASTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGEPVPGQQESSKIPYE
RQQLPKGRP-GPVAGHTQMPR-VPTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NVAAAQLPTSPGH--MHTQVPPY--QPQPYQPAQKY
SFGTGGSA----VYRPQQPVA---PSASNAYPN------TPYIPSA-SSYSGQSQLYAAQ
HQASPPASSPTASFPP-PPASGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAP--LSSQASFPQPHLPGGQP-----FHGVQQPLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSASDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIISGLHNIARSIETRNYAEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQQTNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRVSVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQAAQ-HSVVLPLKKPPKWVRRPVGASFSFGG
KLVTFENVKVQSQQGPEQQQ-Q-QQHRVLVSQVVTEKEFLSRSDQLQQVVQSQGYIAYCQ
KKIDASQIEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKADGA--
----DVALKDSDQVAQSDGEEIHAAEEQLLGECI---KEEKPESEFLPSAR-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQS
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQASDANAVGVLL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPAPGH-GSPKM---
----PKGRP-APIGGHPQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALSSHPPAASPSD
TQGENPPPPGFIMQGNINP-----NAA-AQLPTSAGH--MHSQVPAY-PQPQPYQPAQQY
SFGTGGSA----MYRPQQPVA---PPAPNAFPS------TPYISSA-SSYSGQSQLCAAQ
HQASSPTSSPAAAFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLPSQASFPQPHLPGGQP-----FHGIQQPLGQTGMP-P
SFSKPNVEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGEVSGVLIAGGENGNIILYDPSKIIAGN
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNNFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFAAPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DVSCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHT---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDTLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKVQAQQGP--EQQ--QQHHVFISQVVTEKEFLSRSDQLQQVVQSQGFINYCQ
KKIDASQTEFEKNVWSFLK-VNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----DVALKDSDQVAQSDGEESPAAEEQLLGEHV---KEEKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGDFESAVDLCLHDNRMADAIILAIAGGKELLARTQTKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQALDTNTVGVLL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPVPGQES-AKVPYE
RQPLPKGRP-GPLAGHPQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGSVNP-----NAA-GQLATSSGH--MHPQVPPY-PQPQPYQPAQQY
SFGTGGSA----LYRPHQPVA---PPASNAYPN------TPYISSA-SSCSGQSQLYAAQ
HQASSPTSSPAASLPP-PPSSGASFQHGGPGAPPSSAAYAL-PPGTTGTLPAASELPASQ
RTESQFIQDQ--AL--M-LEGPQNGWNDPPALNRVPKK-KKMP--ENFTPPVPITSPIMN
PLGDPQSQMLQ---QQPPAPGPLSNQASFPQPHLPGGQP-----FHGIQQPLAQTSMP-P
SFSKPNLEGAPGAPIGNTVQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FNNALVSEGRKMQWVPRLADARW--SSAAV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDPKGNVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-VRLLTFIHNEWRVESWDQVSFCTVSLPCGSCKPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
ADKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HNIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKIQSQQGAEQQ--Q-QQHHVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKHVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIALALNKVDGP--
----EVALKDSDQVAQNDGEESPAAEEQLLGECI---KEGKQESEFLPSAG-GTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 800)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGQPVPGQ-ESPKIPYE
RQQLPKGRP-GPMAGHTQMPR-VPAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NTATAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGST----MYRPQQPVA---PSASNAYPN------TPYISPA-SSYSGQSQLYATQ
HQASPATSSSAAAFPP-PPSSGASFQHGGPGAPPSSSAYAL-PSGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKKKKKMP--ENFMPPVPITSPIMN
PLGDPQSQMLPQ---QPSAPVPLSSQASFPQPHLAGGQT-----FHGIQQPLGQPGMP-S
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIESRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNVSGVLIAGGENGNIILYEPSKILTGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISIYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKMLSQQSAEQQ----QHHHVFISQVVTEKEFLSRSDQLQQVVDSQGFIHYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEELAKKIALALSKVDGP--
----NVALKDSDQVAQSDGEESCAAEEQLLGESF---KEEKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDNLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVIILRKAIQLTQTTDANTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIMQLRDRLCRAQGQPVTGQ-ETPKIPYE
RQQLPKSRP-GPTVGHTQMSR-VPTQQYYPHVRIAPTVTTWSNKTPTALPSHLPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-TQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----MYQPQQAVI---PPASNAYPN------TPYVSSA-SSYSEHSQLYAAQ
HQASLPTSSPATSFPP-PPSSGASFQHGGPGAPPLSSAFAL--PGTTGTLPDASELPASQ
RT------------------GRQNGWNDPPALNRVPKK-KKVP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVQLSSQASFSQPHLPGGQP-----FHGIQQPLGQPGIP-P
SFAKPNIEGAPGAPTGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDVSKRLEFLYDKLREQTLSPTIISGLHSIARSIETRNYPEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPSQHHPIYLATGTSAQQLDATFSTNASLEIFELDLT
DPSLDMKSCATFSSTH-RYHKLIWGPPQVASDGNLSGVLIAGGENGNIILYDPAKILAGE
SEVVIAQKD

PF00400 // ENSGT00390000003175_1_Domain_0 (130, 162)

KHTGPVRALDVNLFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLESHA---RGILTIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTTTQWCFDVQWCPRNPALLSAASFDGRISIYSIMGGSPDSLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQLPQQTP--QSTILPLKKPPKWIRRPVGASFSFGG
KLVTFENSRSQQQGPE--QQQQPPHYHVYVSQVVTEKEFLSRSDQLQEAVQAEAFINYCQ
KKIDAARNDFEKNVWSFLK-VHFEEDS-RGKYLELLGYK-KDDLGQKITSALHKESLHSR
EPAVRKALEAFDQSAQSDGEEGLVAKDRHLGEQRNRIKKTENETDALSST-KETFNISVT
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLSRTQKKYFAKTRGKIT
RLITAVVTKNWKEIVQSCDLQNWREALAAMLTYARPDEFASLCDLLGARLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGNSPLSLQNLIEKVVILRKAVQQTQVMDGNAVGALL
--------NLLASQGSIAAALAFLPANTNQPNVVQLRERICRAQGELPRGPEA-PKASYE
RQPTAKGRG-GPSAGQMQMPQQIPAQQYYQQ-----------------------------
--GENPPPPGFVMQGAVNP-----NVPPHQPAPPGYN--MYSQVGTRPPYPQPCQPAQQC
SYGTGGPS----LYQPQQQPLAPPPPASVSYAN----PNPPYMPSN-PPSSMPSSLYSAQ
PQLSPTTLNPNSPLPPPPPPSGASFQHGRPGAPAHSMPYAL-PPGPTGTEPATSELAASQ
R------------------TGPQNGWNDPPALSRVAKK-KKMP--DNFMPPVPITAPIMN
PLSDPQAQMQQL----PP-TSAPPAQGPFQPSHLPPGQPVLQNPFQNIQQPVGQTIMT-P
SVSASSMEGAPGAPIGNTIQHVQSLPTEKITKKPIPEEHLILKTTFEALIQRCLSSATDP
QTKRKLDDANKRLEFLYDKLRDQTLSPTIINGLHNIARSIETRNYVEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFEFDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCVAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HNIVLPLKKPPKWTRRPVGASFSFGG
KLVTFENGRVQAQQGAEP------HHHVFVSQVVTEEEFLRRSDQLQQVVRSQGFVSYCQ
KKIEASQTEFEKNVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIAVALSKVDGP--
----NAALKDSDQVAQSDGEESPAAGEQLLGECI---KEGKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSTLCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCKAQGQPIPGQ-ESSKTPYD
RQQLPKGRP-GPVAGHTQMPR-VPAQQYYPHVRTAPTVTSWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAATAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----ACRAPQPVT---PSASNAYPN------TPYMSPA-SSYSGQPPLYAAQ
HQASLPASSSAAAFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAAGELPASQ
RTENQFMQD-----QALMLEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLPQ---QPSVPAPLSSQASFPQPHLAGGQT-----FHGVQQPLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIISGLHNIARSIESRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPARNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMRSCATFSASH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA--RYRAAAPSARMLKQDW----------
-----------FHLIFNFFFF---------------------FFFFSIF-----------
----VHRFGQILDPFGLGKPPPFPWQIPPA-ST-ASPTAPF----AAPKKPVGAAFSFGG
KLVTFENVRGQSQQGA--EQPP--KHQVFVSQVVTEREFLSRSDQLQQAVRSQGYAAYCQ
KKIDASQVEFEKNVWSFLK-VNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKADGP--
----DVALKDSDQVAQSDGEDSHAAEEQLLGERI---KEEKQESEFLPPAR-GTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 739)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCE--------RGDSLLQS
QACLCYICAGNVERLVACWAKAQDRSHPLSLQDLIEKVVIPAKAVQLTRPR-TGRRGALL
AEKKSTYC--------------------HTPNIVQLRDRLCRAQGEPVPGHAS-PKVPCE
KQQLPKGRL-GPIAGHPPMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAACPSD
PKGENPPPPGFIMHGNMNP-----SAA-AQRPTSPGH--MHAQGPPF-PQPQPCQAAQQY
SFGAGGPA----AYRPQQPVA---PPASNAYPN------TPYLPPA-ASYPGPSPLYQA-
---SAPASSPAPAFPP-PPPSGGSFQHGGPGAPPASSAYAP-PPGTPGTLPAAGELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKMP--ENYTPPVPITSPIMH
PVGDAPSQVLQ---QQPAAPVPPPSQPAFPQPHLPP---F----PGGIQQPLGQAGVPPP
AFSKPNIEGAPGAPIGNTVQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQT------------------------------------
------------------------------

---------MKLKEIDLTAMQAWSPAQQHPIYLATGTSAQQLDASFSTNASLEIFELDLS
DPSLDMKSCAVISSSH-RYHKLIWGPHSMTAGESVSGVLIAGGENGNVILYDPAKILVGN
SEAIIAQKDK

PF00400 // ENSGT00390000003175_1_Domain_0 (131, 162)

HTGPVRALDVNMFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPLE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHNNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFT

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLESHT---RGILAIAWSMADSELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNMQWCFDIQWCPRNPAIFSAASFDGRISTYSIMGGSTDGLRQKH
VDQLSSSF-GNLDPFGTGQPLP-PLQLPQQTAP-QSVVLPLKKPPRWIRRPVGASFSFGG
KLVTFENAKPQQQPGV--DQQP-QHHYVYVSQVVTEKEFLARSTQLQEAVQSEGFVSYCQ
KKIDMAQADFERNVWAFLK-VNFEEDS-RAKYLELLGYR-KDDLKNKITSALNLNKECCA
DGELGEAPTESDVPLLNKGDEGQTAEEQFLGEMA---KDNKQETEDLGSAR-KTFNISVS
GDVDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLSRTQEKYFSKIQSKIT
RLITAVVTKNWKEIVQSCDLQNWREALAAVLTYARPDEFAALCDLLGNRLESEGDSLLRT
QACLCYICAGNVEKLVACWSKVQDGNSPLSLQDLIEKVVILRKAVQLTQAVDPNAVGALL
AEKMSQYANLLAAQGSIAAALTFLPANTDQPNIVLLRDRLCRAQGELPAGQEA-IRAPYE
RQPIPKDRA-GPVVGQVPGPQ-TSAQQYYQQ-----------------------------
--GDKPPPPGFIMPGAVNP-----SAPPQQATSPSYS--MYSQAGTRPAYPQTYQSTQQY
SFGTGETA----LYQPQQPIA---APASASYPSPASNTNPPYLPTA---HPVPSSLYPGQ
PQPSPTSLNPASSFPL--PPSGASFQHGRPGLPATSVAYAL-PTGPTGTLPAASDLPASQ
R------------------TGPQNGWNDPPALNRTAKK-KKVP--DNFMPPVPITSPIMN
PLADPQAQTQQP-------PAAPVGTPSFQPPQLPAGQQAPLGPYA---PQALGPGVVPP
TTFKPRTEGAPGAPIGNAM---QALPTEKITKKPIPEEHLILKTTFEALIQRCLLSASDP
QTKRKLDDANKRLEFLYDKLREQTLSPAIVSGLHSIVKSIETRNYVEGLNIHMHIVSTSN
FSETSAF-------MPVLKVVLIQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNVSGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVA-GANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNN-ATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCISWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPEVATQ
MVLASEDDRLPVVQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAA-HSVVLPLKKPPKWIRRPVGASFSXXX
XXXXXXXXXXXXXXXX--EQPA-APQLVFVSQVVTEREFLSRAEQLQQAVQAQAFGAYCQ
RKVDASASEFEKNVWSFLK-VNFEDDS-RGKYLELLGYR-KEDLGKKIASALNKADGP--
----GVARADSDPVAQSDGEESCAAGEQPVGEHI---KEEKEEREFLPSAG-GTFNISVS
GDIDGLITQALLTGNFASAVDLCLHDNRMADAIVLAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWREIVESCDLKNWREALAAVLTYAEPDEFPALCDLLGSRLEREGDGLLQT
QACLCYICAGNVEKLVACWNKAQDGSNPLSLQDLIEKVVILRKAVQLTQALDAGTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGGPAPAQEA-AKVPYD
RQQLPKGRP-GPMAGHRQMPR-LPTQQYYPQ-----------------------------
--GENPPPPGFIMHGTIQP-----GATA-PPPPTSGH--MPTQVAAY-TQPQPYQPAQPY
PFGAGGSA----AFRPPQPPA---PPASSAYPS------APYVSST-PAYSGQPPLYPAQ
HRASPPATSPAAAFPP-PPPSGSSFQHGGPGAPPSSSAFAL-PPGA-------SELPASQ
R------------------TGPQNGWNDPPALNRVPKK--KMP--ENFLPPAPITEPIMN
PLGDPQSQMLP---PQPSAPAPLAGHASFPQPQQPGGQP-----FHGAQQPLGQPGLP-P
AFPKPSMEGAPGAPIG-TVQHVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
XXXXXXXXXXXXXXXXXXXXXXXXLSPTIINGLHSIARSIETRNYSEGLSIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAVAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSVDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWVRRPVGASFSFGG
KLVTFENVAVPLQQGA--E-QQ-RRQPVFISQVVTEKDFLSRSAQLQHAVQSQGFIGYCQ
KKIEASQTEFEKNVWSFLK-VNFEEDS-RGKCLELLGYR-KEDLGKK-------------
--------------------------------RI---KEEKQDCDFLPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 739)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLRT
QACLCYICAGNVERLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQALDTNTVGALL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGKPVSGQEA-SQSPYE
RQPLSKGRP-GPVAGHSQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMQGNVIP-----SPA-APLPTAPGH--MPSQLPPY-PQPQPYQPAQQY
SFGTGGAA----VYRPQQPVA---PPASNAYPN------TPYISPV-ASYSGQPQMYTAQ
QASSP-TSTSAAAAFP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTPPAASELPASQ
RTENQSFQDQ--AS--I-LEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PSGDPLSQGLQ---QQPSTPGPLSSHTSFPQPHLAGGQP-----FHGVQQPLAQTGMP-P
SFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLELLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLSVHTHIVSTSN
FSETSAF-------MPVLKVVLSQASKLGV

---------MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQKDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRIRVYSIMGGSIDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTSQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVTGQPQQGA--E-QP-RRQPVFISQVVTEKDFLSRSEQLQHVVQSQGFISYCQ
KKIDASQTDFEKNVWSFLK-VNFEEDS-RGKYLELLGYR-REDLGEKIALALNRVDGS--
----DVALKDSDRVAQSDGEESPAEEGQLLGERI---KEEKQECDFLPSAGGGTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDSLLRT
QACLCYICAGNVERLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQALDTNTVGALL
AEKMSQYANLLAAQGSIAAALAFLPDNTNQPDIVQLRDRLCRAQGRSVPGQES-SRSSYE
GQPLPKGGP-GPLAGHPQVSR-VQSQQYYPQVRIAPTVTTWSDRTPTALPSHPPAACPSD
TQGGNPPPPGFIMHGNVVP-----NSP-APLPTSPGH--MHSQPPPY-PQPQPYQPAQQY
SFGTGGSA----VYRPQQPVA---PPASNAYPN------APYVSPV-ASYSGQPQMYTAQ
PASSP-TSSSA-PLPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTPPAASELPASQ
R------------------TGPQNGWNDPPALNRVPKK-KKLP--ENFMPPVPITSPIMN
PGGDPQPQGLQ---QQPSASGPRSSHASFPQPHLAGGQP-----FHGIQQPLAQTGMP-P
SFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLECLYDKLRDQTLSPTIISGLHSIARSIETRNYSEGLTVHTHIVSTSN
FSETSAF-------MPVLKVVLSQASKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ---QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----DVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSPLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPV-GHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSPPIPLSSQSSFPQPHLSGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHSIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

------------------------------------TSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-TNLVASGANESEIYIWDLNNFATPMTPGAKTQXXX
XXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXMHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTSQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKMLSQQGSE----QQQHHHVFISQVVTEKEFLSRSDQLQQVLESQGFINYCQ
KKIDASLTEFEKNVWSFLK-VNFEDDS-RGKYLELLGYR-KEDLAKKIAFALNRVDGP--
-----DRALDSDQVAQSDGEEPAAEK-QLL----RNIRVEKQESEFLPSA-GGTFNISIS
GDIDGLITQALLTGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFLGTRLESEGDSLLRT
QACLCYICAGNXXXXXXXXXXXXXXXXXXXXXDLIEKVVILRKAVQLTQTMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXX---XXXXXXXXX-XXXXXXXXX-----------------------------
--XXXXX-XXXXXXXXXXX-----XXXXXXXXXXXXX--XXXXXXXXXXXXXXYQPAQQY
SFGTGGSA----MYRPQQPVP---PPASNAYPN------TPYIPSA-SSYSGHCQLYATQ
HQVSLPTSSPAASFPP-PPSSGASFQHGGPGAPPSSSAYALPP--ATGTLPDASELPASQ
R------------------TGRQNGWNDPPTLNRVPKK-KKXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXX--------XXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X
XXXITKPISAAGAPTGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTRRKLDDVSKRLEFLYDKLREQTLSPTIISGLHSIARSIETRNYPEGLSIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQKDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAVAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSVMGGSIDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFESVAVPLQQGA--E-QQ-RRQPVFISQVVTEKDFLSRSAQLQHAVQSQGFIGYCQ
KKIEASQTEFEKNVWSFLK-VNFEEDS-RGKYLELLGYR-KEDLGKKIALALNKVDGS--
----DVALKDSDQVAQSDGEESPAAEEQLLGERI---KEEKQECDFLPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 739)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLEREGDSLLRT
QACLCYICAGNVERLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQALDTNTVGALL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGKPVSGQES-SQSPYE
RQPLSKGRP-GPVAGHSQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMQGNVIP-----NPA-APLPTAPGH--MPSQLPPY-PQPQPYQPAQQY
SFGTGGAA----VYRPQQPVA---PPASNAYPN------TPYISPV-ASYSGQPQMYTAQ
QASSP-TSSS-AASFP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTPPAASELPASQ
RTENQSFQDQ--AS--I-LEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PSGDPQSQGLQ---QQPSTPVPLSSHASFPQQHLAGGQP-----FHGVQQPLAQTGMP-P
SFSKPNTEGAPGAPIGNTIQHVQALPTEKITKKPIPEEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLSVHTHIVSTSN
FSETSAF-------MPVLKVVLSQASKLGV

MTPVFPFNRMKLKEIDRTAMQAWSPAQHHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCAIHSSSHRRYHKLIWGPHKMDSDGNLSGVLIAGGENGNIILYDTAKILAGD
GEVVMAQKDK

PF00400 // ENSGT00390000003175_1_Domain_0 (131, 162)

HTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFGTPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNRKVHCHHLI--------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
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------------------------------

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNISGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-VRLLTLGVNESEHYLSNINSFKACIFP--------
---------------------------------------QNKVE-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTTTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTTP-QSIVLPLKKPPRWIRRPVGASFSFGG
KLVTFANVRTQPHPGAEQQ--P-QQHHVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGP--
----DVALKDSDQVAQGDGEESPAAEEQLLGEQI---KEEKQESEFLPAAG-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWREIVESCDLKNWREALAAVLTYAKSDEFSALCDLLGTRLESDGDSLLQT
QACLCYICAGNVEKLIACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGDPIPGPQESPKIPYE
RHQVPKNRP-GPGAGHAQMPR-VPAQQYYPH-----------------------------
--GENPPPPGFVMHGNVSP-----NVAAAQLPTSPAH--VHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----MYRPQQPVA---PSTSNAYPN------TPYIPSA-SSYSGQSQLYPAQ
HQAPPPTSCPAASFPP-PPSSGASFQHGGPGAPSTSSAYAL-PPGTT-------------
--------------------GPQNGWNDPPALNRGPKK-KKMP--ENFTPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQAPFPQPHLAGGQP-----FRGIQQPLSQPGMP-P
SFSKPNIEGAPGAPIGNTMQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPAQSHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNISGVLIAGGENGNIILYDPSKIIAGD
EEVVIAQKDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA----------------------------
---------VLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRINVYSIMGGSIDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKVQPQHAAEQQQ---QRQHVFISQVVTEKDFLSRSEQLQQVVQSQGFVSYCQ
RKIDASQTEFEKNVWSFL-KVNFEEDS-RGKYLELLGYR-REDLGKKIALALDRVDGS--
----DVALKDPDQVAQSDGEESPAAEEQLLGERI---KEEKQESDFAPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDMNTVGALL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGKPVPGQ-ESSKSPYE
RQPLSKGRP-GPSAGHPQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NTAA-PPPPSPGH--MHNQLPPY-PQPQPYQPAQQY
SFGTGGSA----AYRPQQPVA---PPASNAYPN------PQYISPA-TSYSGQPQMYTAQ
QA-SSPTSNSAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTTPAASELPASQ
RTENQFFQD-----QASVLEGPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PAGDPQSQMLQQ---QPSAPGPLSSQASFPQPHLVGGQP-----FHGVQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTIQHVQAMPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLTVHTHIVSNSN
FSETSAF-------MPVLKVVLSQASKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRVSVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ---QQHHVFVSQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYK-KEDLGKKIALALNKVDGA--
----DVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPV-GHHQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPIPLSSQSSFPQPHLSGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHSIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGSVSGVLIAGGENGNIILYDPSKIIAGD
KEVVVAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 264)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFATS

PF00400 // ENSGT00390000003175_1_Domain_2 (264, 300)

PLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HNIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENIRMQSQQGAEQQ--Q-QQHHVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFENDSQRGQLLGITLYSRDQSCGQVIALALNKVDGT--
----DVALKDSDQLAQSDGEESPAAEEQLLGEHI---KEEKQESEFLPSAG-KTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWREIVESCDLRNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAVDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGEPTLGQ-ESPKIPYE
RQQLPKVRP-GPVAGHTQMPR-VPTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAAVAPLPTSPGH--MHTQIPPY-PQPQPYQPAQQY
SFGTGGSA----MYQPQQPVA---PSASNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQVSPPTSSPTASFPP-PSSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRIPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQASFPQPHLPGGQP-----FHGIQQPLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIISGLHSIARSIETRNYSEGLTIHTHVVSTSN
FSETSAF-------MPVLKVVLTQAHKLGV

------------------------------------TSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASANPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPANTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPHQTAQ-HRIVLPLKKPPKWVRRPVGASFSXXX
XXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXX-XVNFEDDS-RGKYLELLGYR-KEDLGKKIASALNKVDGP--
----DVALKDSDQVAQSDGEESPAAEEQLLGERI---KEEKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGNPA-GQQESPKIPYE
RQQLPKGRP-GPVAGHTQMPR-VPAQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NVATAQLPTSPGH--MHSQVPPY-PQPQPYQPAQQY
SFGTGGSA----VYRPQQPVA---PSASNAYPN------TPYISSA-SSYSGQSQLYTAQ
HQASPPTSSSTASFPP-PPSSGASFQHGGPGAPPSSSAYAL-APGATGTLPAAGELPASQ
RT------------------GSQNGWNDPPALNRVPKK-KKMP--ENFTPPVPITSPIMN
PLGDHQSQMLQQ---QPSAPVPLSSQASFPQPHLPGGQP-----FHGIQQPLSQPGMP-P
SFSKPNIEGAPGAPIGNTMQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNISGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTTP-HSIVLPLKKPPRWIRRPVGASFSFGG
KLVTFASVRTQPQPGPEQQ--P-QQHHVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLEKKIALALNKVDGP--
----DVALKDSDQVAQGDGEESPAAEEQLLGEQI---KEEKHESEFLPTAG-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLIMAVVMKNWKEIVESCDLKNWREALAAVLTYAKADEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQAMDTDTVGALL
AEKMSQYASLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGDPIPGQQESPKIPYE
RHQVPKSRP-GPVAGHAQMPR-VPAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFVMHGNVSP-----NVAAAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----MYRPQQPVA---PSTSNAYPN------TPYIPPA-ASYSGQSQLYPAQ
HQASPPTSSPAASFPP-PPPSGASFQHGGPGAPPASSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRGPKKKKKMP--ENFTPPVPITSPIMN
PLGDPQSQMLPQ---QPSAPVPLPSQAPFPQPHLASGQP-----FRGIQQPLSQPGMP-P
SFSKPNIEGAPGAPIGNAMQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQQHPIYLATGTSAQQLDATFSTSATLEIFELDLA
DPSLDMKSCATFSSSH-RYHKLIWGPHSMTSGDRVSGVLIAGGENGNVILYDSAKIIDGE
AEVIIAQKDK

PF00400 // ENSGT00390000003175_1_Domain_0 (131, 162)

HTGPVRALDVNMFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGVKTQPLE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHNNR-MHCSGLAWHPEVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLESHT---RGILAIAWSLADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGSSADGLRQKQ
VDQLSSSF-GNLDPFGTGQPLP-PLQLPQQTAP-QSVVMPLKKPPKWIRRPMGASFSFGG
KLVTFENSKPLQQLGMEQ----QQHPHVYVSQVVTEKEFLARSNQLQEAVQSEGFVSYCQ
-KIDMALADFERNVW-FLK-VNFEEDS-RVRYLELLGYR-KDDLRKKVSFALLVV-----
PSCNMDAPTESDGSVPNEGDEGQTTEEQFLGETL---KDHKKETEDLGCA-KTTFNISVS
GDVDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLSQTQEKYFAKMRSKIT
RLITAVVTKNWKEIVQSCDLQNWREALAAVLTYARPDEFTALCDLLGSRLENEGDSILQT
QACLCYICAGNVDKLVACWTKVQDGNSPLSLQDLIEKVVILRKAVQLTQAVDPNAMGALL
AEKMSQYANLLAAQGSLAAALTFLPANTNQPNIVQLRDRLCRAQGELPVGHNG-LKGQYE
REPMSKGRA-GPMAGQMQAPQ-APAQQYYQ------------------------------
-QGDNPPPPGFIMPGAVGP-----SMPPQQAISSNYS--MGQS--PPHPKQHSYQATQQY
SSGTGVAA----LYQPQQPIA---APS-QPYPNPAPNTTPSYLPFA-PAHSVPSPLYPGQ
PQPSPTSLNPASSFPV--PPSGTSFQHGRPGLPATSVAYAL-PTGPTGTLPAASDLPASQ
R------------------TGPQNGWNDPPTLNRAAK--KKVP--DNFLPPVPITSPIMN
PLVDPQSQMQQ-----PQAPAPPSKAPSFQPPHLPAGQMVLQGGFQPAAQPLGPSTM-PP
TVSKPSMEGAPGAPIGNAIQHVQALPTEKITKKPIPEEHLILKTTFEALIQRCLLSTSDP
QTKRKLDDANKRLEFLYDKLREQTLSPNIISGLHNIVKSIETRNYQEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---MKEISRMKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQN

PF00400 // ENSGT00390000003175_1_Domain_0 (129, 162)

DKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGAKTQPPE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGE---------------------------------------------------
---------------------------------------------------------FGG
KLVTFENVRMPSHQGAEQQ--Q-QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGH-ESPKIPYE
EQQLPKGRP-GPVAGHHQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYTGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQH-----FHGIQQPLGQIGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFS-SH-RYHKLIWGPHKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNNKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCISWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASTPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPALLSAASFDGHISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTTQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFGNVKVHSQQGAEQQ----QQQHVFISQVVTEKEFLNRSDQLQQVMQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KDDLGKKIALALNKMDGS--
----DVALKDSEQVTQSDGEESPAAEEQVLGEHI---KEEKHEYEFLPPSG-GTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQRKYFAKSQSKIT
RLITAVVMQNWKEIVQSCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRNRLCRAQGEPIPGQ-ESPKIPYE
RQQLSKGRP-GPIAGHPQMQR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFVMHENINP-----NAA-TQLPTSPGH--MHTQVPPY-PQPQLYQPAQQY
SFGTGGSA----MYRPQQPVA---PPASNAYPN------TPYISSA-SSYSGQSQLYTPQ
HQASSPTSSPAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFTPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSNQASFPQPHLAGGQH-----FHGIQQPLGQTGMP-P
AFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSHSQYHPIYLATGTSAQQLDATFSTNASLEIFELDLA
DPSMDMKSCATFSSTH-RYHKLIWGPHRTASNGSASGVLIAGGENGNVILYDPAKIIEGD
R

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQQDKHTGPVRALDVNSFQ-TNLVASGANESEIYIWDLNNFAVPMTPGAKSQPLE
DIGCIAWNRQVQHILASASPSGRATVWDLRKNEPILKVSDHSNR-MHCSGMAWHPDVATQ
MVLSSEDDRLPVIQMWDLRFASSPLRVIESHTSTSRGILAIAWSLADPELLLSSGKDSRI
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNMQWCFDMQWCPRNPAVLSAASFDGRISIYSIMGGNNDSLSQKQ
ADKLSSSF-GNLDPFGTGHPLP-PLQLPQQPTQ-QNTIVPLKKPPKWMRCPVGASFSFGG
KLVTFETVNTQTAQQQQHPEAEPHHFHVYVSQVVTEKEFLTRSNQLQDVVSTGTFIDYCQ
KKVEDAKTDFEKDVWSFLKVVNFEEDT-RGKYLELLGFR-KDDLSSKLLLLLLLLLGG--
----NTAEKDSDQAIASDEEERQHSEDNFLAEVS---KDDKRQSSGSNS-PGESLNILVS
GDVDGLITQALLTGNFESAVNLCLHDNRMADAVILAIAGGPELLAKTQRKYFAKSQSKIT
RLITAVVTKNWNEIVQSCDLKNWREALAAVLTYTKPDEFSSLCDLLGSRLENEGDIALQT
QACLCYICAGNVEKLVSCWTKAHDSNCSLALQDLIEKVVILRKAVE------TNDMGTIL
SQKMSQYANVLAAQGSLAAAMAFLPTDAHQGDVVQLRERLCRAQGQEDITGVPSPHFPQE
LQFTPKHRHPEPLCFISELPL---------------------------------------
LQRNSALPLGFNIPGSTYTSGSLASVASADSSAPSYN--INSQITPRLPYSQPYLQSQQY
SYGMGGPA----VYQPQPPSTVP---SATPYHN------SSYTSAS--------------
------QTTTQPLY--PGPASGASFQHGGPGAPANTAHCALPPPGSTGTLPATSELPASQ
R------------------TGPLNGWNDPPALSRISKK-KEVL--ENYVPPPPITAPIMN
PVTDPSSQQQQIPAS-----GTQMPSIPFQPSTMLVAQPGTQTSFPISQPCNSQPGL-PL
ESSKPSMEGAPGAPIGNTIQAIHTLPAEKIVKNPIPGEHLILKTTFEALIQRCLCSANDP
QTKRKLDDANKRLEYLYDKLREQTLSPAIIAGLHNIARSIESRNYTEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPAQQHPIYLATGTSAQQLDATFSTSASLEIFELDLA
DPSLDMKSCATFSSSH-RYHKLIWGPHSMTSGDRVSGVLIAGGENGNVILYDTAKILDGE
AEVIIAQKDK

PF00400 // ENSGT00390000003175_1_Domain_0 (131, 162)

HTGPVRALDVNMFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 181)

DLNNFATPMTPGVKTQPLE

PF00400 // ENSGT00390000003175_1_Domain_1 (181, 208)

DISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 263)

DLRKNEPIIKVSDHNNR-MHCSGLAWHPEVATQ
MVLASEDDRLPVIQMWDLRFAS

PF00400 // ENSGT00390000003175_1_Domain_2 (263, 300)

SPLRVLESHT---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDQLSSSF-GNLDPFGTGQPLP-PLQLPQQTAP-QSVVLPLKKPPKWIRRPMGASFSFGG
KLVTFENSKSVQQPGMEQ---QQQHPHVYVSQVVTEKEFLARSNQLQEAVQSEGFVSYCQ
KKIDMALADFDRNVWAFLK-VNFEEDS-RVKYLELLGYR-KDDLRNKITSALNKEG--LA
DGVLGEAPAESDGSVPNKGDEGQTTEEQFLGETL---KDHKKETEDSGSA-KTTFNISVS
GDVDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLSRTQEKYFAKMRSKIT
RLITAVVTKNWKEIVESCDLQNWREALAAVLTYARPDEFTALCDLLGSRLENEGDSILQT
QACLCYICAGNVDKLVACWTKVQDGNSPLSLQDLIEKVVILRKAVQLTQAADPNAMGALL
AEKMSQYANLLAAQGSLAAALTFLPANTNQPNIVQLRDRLCRAQGELPVGQDG-LKGPYE
REPMAKGRA-GPVAGRMQAPQ-APAQQYYQQVRIAPTVTTWSNKTPTALPSHPPAGCPSD
TQGDNPPPPGFIMPGAVGP-----SVPPQQATSSNYS--MYSQAGARPPYPQTYQATQQY
SSGTGGPA----LYQPQQPIA---APASASYPSPAPNTTPSYLPSA-PAHPMPSPLYPGQ
PQPSPTSLNPISSFPA--PPSGTSFQHGRPGPPATSVAYAL-PTGPTGTLPATSDLPASQ
RTESLPSQDQASLF--AGELGPQNGWNDPPTLNRAAKK-KKVP--DNFLPPVPITSPIMN
PLADPQAQLQQ-----PQAPAPPSSAPSFQPPHLPAGQVVLQGGFQPASQPLGPSIM-PP
TVSKPSTEGAPGAPIGNAIQHVQALPTEKITKKPIPEEHLILKTTFEALIQRCLLSASDP
QTKRKLDDANKRLEFLYDKLRDQTLSPTIISGLHNIVKSIETRNYQEGLNIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEIDRTAMQAWSPAQSHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDSKGNISGVLIAGGENGNIILYDPSKIIAGD
EEVVIAQKDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRINVYSIMGGSIDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKVQPQHAAEQQQ---QRQHVFISQVVTEKDFLSRSEQLQQVVQSQGFVSYCQ
RKIDASQTEFEKNVWSFL-KVNFEEDS-RGKYLELLGYR-REDLGKKIALALDRVDGS--
----DVALKDPDQVAQSDGEESPAAEEQLLGERI---KEEKQESDFAPSAG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 743)

ITRALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGARLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDMNTVGALL
AEKMSQYASLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGKPVPGQ-ESSKSPYE
RQPLSKGRP-GPSAGHPQMPR-VQTQQYYPHVRVAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NTAA-PPPPSPGH--MHNQLPPY-PQPQPYQPAQQY
SFGTGGSA----AYRPQQPVA---PPASNAYPN------PQYISPA-TSYSGQPQMYTAQ
QA-SSPTSNSAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTT-------------
--------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PAGDPQSQMLQQ---QPSAPGPLSSQASFPQPHLVGGQP-----FHGVQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTIQHVQAMPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHSIARSIETRNYSEGLTVHTHIVSNSN
FSETSAF-------MPVLKVVLSQASKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTSASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKMDPKGNVSGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HNIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKTQAQQGAEQQ--Q--QQHVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIALALNKVDGP--
----DVALKDSDQVAQNDGEESPAAEEQLLGECI---KEGKQESEFLPSAG-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLAQTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGQPVPGQ-ESPKIPYE
RQQLPKGRP-GPMAGHTQMPR-VPAQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAATAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGST----MYRPQQPVA---PSASNAYPN------TPYISPA-SSYSGQSQLYASQ
LQASPPTSSSAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKKKKKMP--ENFMPPVPITSPIMN
PLGDPQSQMLPQ---QPSAPVPLSSQASFPQPHLAGGQT-----FHGIQQPLGQLGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIESRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHNLIWGPYKMDSKGNVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVVQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSADGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMQSQQGAEQQ--Q-QPRPVFISQVVTEKEFLSRSDQLQQVVQSQGFVSYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDSR-GKYLELLGY-RKEDLGKKIALALNKVDEP--
----DVALKDSDQVAQSDGEESPAAEEQLLGECI---KEGKQESEFLPPAG-RTFNISIS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 740)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDILLQT
QACLCYICAGNVEKLVACWTKAQDGSSPLSLQDLIEKVVILRKAVQLTQAMDTNTVGVLL
AEKMSQYANLLAAQGSIAAALAFLPENTNQPNIVQLRDRLCRAQGQPVPGQ-ESSKIPYE
RQQLPKGRP-GPMAGHTQMSR-VPAQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NATTAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGST----MYRPQQPVA---PSASNAYPN------TPYISSA-SSYSGQSQLYATQ
PQASPPTSSSAASFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RTENQSMQD-----QAPMLEGPQNGWNDPPALNRVPKK-KKIP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPLPLSSQASFPQPHLPGGQT-----FHGIQQPLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIINGLHNIARSIETRNYSEGLTIHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---MKDISRMKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDIATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ---QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFINYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----DVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIVQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPV-GHHQMPR-VQTQQYYPH-----------------------------
--GENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTETHSVQDQA--PM
LE------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPIPLSSQSSFPQPHLSGGQP-----FHGIQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHSIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPYKMDSKGDVSGVLIAGGENGNIILYDPSKIIAGD
KEVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
DISCIAWNRQVQHILASASPSGRATVWDLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFASSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAKI
LCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVRMPSHQGAEQQQ-Q-QQHHVFISQVVTEKEFLSRSDQLQQAVQSQGFISYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGA--
----NVALKDSDQVAQSDGEESPAAEEQLLGEHI---KEEKEESEFLPSSG-GTFNISVS
GDIDGL

PF12931 // ENSGT00390000003175_1_Domain_4 (607, 744)

ITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLKNWREALAAVLTYAKPDEFSALCDLLGTRLENEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSHPLSLQDLIEKVVILRKAVQLTQAMDTSTVGVLL
AAKMSQYANLLAAQGSIAAALAFLPDNTNQPNIMQLRDRLCRAQGEPVAGH-ESPKIPYE
KQQLPKGRP-GPVAGHHQMPR-VQTQQYYPHVRIAPTVTTWSNKTPTALPSHPPAASPSD
TQGENPPPPGFIMHGNVNP-----NAA-GQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
PFGTGGSA----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYTGQSQLYAAQ
HQASSPTSSPATSFPP-PPSSGASFQHGGPGAPPSSSAYAL-PPGTTGTLPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENFMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQSSFPQPHLPGGQP-----FHGVQQPLGQTGMP-P
SFSKPNIEGAPGAPIGNTFQV----------TKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV

---------MKLKEVDRTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-TNLVASGANESEIYIWDLNNFATPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHNNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

TSPLRVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAILSAASFDGRISVYSIMGGSSDGLRQKQ
VDKXXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXFGG
KLVTFENVKMLSQQGA--EQQ--QHHHVFISQVVTEKEFLSRSDQLQQVVQSQGFVNYCQ
KKIEASQTEFERNVWSFLK-VNFEEDS-RGKYLELLGYR-KEELGKKIGLALDKMDRP--
----DVALKDSDQVALSDGEESPAAEEQLLGERI---KEENQESEFLSSVG-GTFNISVG
EDVDGLITRALLTGSFESAVDLCLRDDRMADAIILAIAGGQELLARTQRKYFAKSQSKIT
RLITAVVMKNWKEIVESCDLNNWREALAAVLTYAKPDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQRTQTVDTNTVGVLL
AEKMSQYASLLAAQGSIAAALAFLPENTNQANIVQLRDRLCRAQGEPIPRHET-PKIPYE
RQPLTKGRP-GPTTGHTQMPR-VPAQQYYPH-----------------------------
--GENPPPSGFMMHGNVNP-----NTA-TQLPTSPGH--MHTQVPPY-PQPQPYQPAQPY
SFGTGGST----MYRPQQPVA---PPTSNAYPN------TPYISSA-SSYSGQSLLYATQ
HQVSPPTSSPAAAFPP-PPSSGASFQHGGPGAPPSSSAYAL-SPGTTGTLPDASELPASQ
R------------------TGPQNGWNDPPALNRVHK--KKMP--EHFMPPVPITSPIMN
PLSDPQSQMLQQ---HTPAPVPLSNQA-SPQSHLSGGQP-----FQSIQQPLGQPGMPP-
-FSKPN-EGAPGAPIGNTIQ----------------------------------------
------------------------------------------------------------
------------------------------

---------MKLKEVDLTAMQAWSPAQNHPIYLATGTSAQQLDATFSTNASLEIFELDLS
DPSLDMKSCATFSSSH-RYHKLIWGPHKVDSKGNISGVLIAGGENGNIILYDPSKIIAGD
K

PF00400 // ENSGT00390000003175_1_Domain_0 (122, 162)

EVVIAQNDKHTGPVRALDVNIFQ-TNLVASGANESEIYIW

ENSGT00390000003175_1_Linker_0_1 (162, 182)

DLNNFTAPMTPGAKTQPPE
D

PF00400 // ENSGT00390000003175_1_Domain_1 (182, 208)

ISCIAWNRQVQHILASASPSGRATVW

ENSGT00390000003175_1_Linker_1_2 (208, 262)

DLRKNEPIIKVSDHSNR-MHCSGLAWHPDVATQ
MVLASEDDRLPVIQMWDLRFA

PF00400 // ENSGT00390000003175_1_Domain_2 (262, 300)

SSPLHVLENHA---RGILAIAWSMADPELLLSCGKDAK

ENSGT00390000003175_1_Linker_2_3 (300, 308)

I
LCSNPNT

PF00400 // ENSGT00390000003175_1_Domain_3 (308, 347)

GEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVYSIMGGSTDGLRQKQ
VDKLSSSF-GNLDPFGTGQPLP-PLQIPQQTAQ-HSIVLPLKKPPKWIRRPVGASFSFGG
KLVTFENVKMQSQQGAEQQQ-Q-QQQHVFISQVVTEKEFLSRSDQLQQVVQSQGFVNYCQ
KKIDASQTEFEKNVWSFL-KVNFEDDS-RGKYLELLGYR-KEDLGKKIALALNKVDGP--
----DVXXXXXXXXXXXXXXXXXXXXXXXXXXRI---KEEKQELEFLPSAR-GTFNISIS
GDIDGLITQALLTGNFESAVDLCLHDNRMADAIILAIAGGQELLARTQKKYFAKSQSKIT
RLITAVVMKNWREIVESCDLKNWKEALAAVLTYAKLDEFSALCDLLGTRLESEGDSLLQT
QACLCYICAGNVEKLVACWTKAQDGSNPLSLQDLIEKVVILRKAVQLTQAVDTKAVGVLL
AEKMSQYANLLAAQGSIAAALAFLPESTNQPNIVQLRDRLYKAQGEPVPGQ-ESTKVPYE
RQQLPKGRP-GPIAGHTQMPR-VPTQQYYPH-----------------------------
--GENPPPPGFLVHGNVNP-----NVAAAQLPTSPGH--MHTQVPPY-PQPQPYQPAQQY
SFGTGGSA----AYRPQQPVA---PSTSNAYPN------TPYISPA-SSYSGQSQLYAAQ
HQVSPPTSSPT-AFPP-PPSSGASFQHGGPGAPPS-SAYAL-PPGTTGILPAASELPASQ
RT------------------GPQNGWNDPPALNRVPKK-KKMP--ENYMPPVPITSPIMN
PLGDPQSQMLQQ---QPSAPVPLSSQASFPPSHLPGGQPS----FHGI--PLGQPGMP-P
SFSKPNIEGAPGAPIGNTIQHVQSLPTEKITKKPIPDEHLILKTTFEDLIQRCLSSATDP
QTKRKLDDASKRLEFLYDKLREQTLSPTIISGLHNIARSIETRNYSEGLTTHTHIVSTSN
FSETSAF-------MPVLKVVLTQANKLGV