Query Results 

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGSHVEISESSLES---DSEADS-PPSEDLD--PADPPI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSVRWSSSSSSSSGSGSSGGGS
SSS---SSSSS---EEDEPEPEQAQAGEGDR--------ALLSPQYMVPDMDLWVPARQS
TSQP-WRGGAGAWLGGPAASL----SPPKGSSASQGGSKEASTTAAAPGE--ETSPVQVP
ARAHGP-VPRA--AQASHS----------ADTRLA--GAEKQALEGGRRLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVVPCTQASQRPAIVQTHADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAS-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQ-----EARA-REATRGPVVLPS-----QLLVSSPVI
LQPPLP--HTPHGRP-APGPTV----LNVPLSGP--------------GAPAAAKP--GT
SGSWQEAGT-SAKDKRL--STMQA-------------------LPLAPAFTEAEGTAPAA
SQAPALGPGQISVSCPESGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPTLLPVQPLSLT-----HIGGPHVATSIPLPVTWVLTAQGLLPVPVPAVVSLPR
PAG-TPGPAGLLATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NMNREPEPSCRTDTPAPPTHVLSQSPAEVAGSVAF------VPGEA
QVAREIPEP----RMS------SH---ADP--PEAEPP-----------WSGRLPAFGGV
IP------------------------------PGPEKGGALDLEKPPLPQP--GPEKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVVGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSVPSRVGSES--EDED----LSELELA--DR--DGQPGCATAT
--------------------------CPIQGAPDSGKCCASSCLDASND--PDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHMEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERGGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEASLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEEEP--EPEQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHAASL----SPPKGSSASQGGSKEASATAVAPGE--ETSAVQAP
ATAHSP-VPRA--AQASHS----------ADTHPV--GPEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAP-SSAQS
--TPGHLLPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPAAAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSQVSVSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAVPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSG
PAG-TPGPTGLVATLLPPLTEA---QGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTVPPAPPTHAASRGPAEVDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPP-----------LPRRLPPLGGV
IPASEPGGTLGSPSGTQEPKGTLDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEAEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLRDNPAYLLLRARFLATFT
LPALLATLAPHGIRTTLSAASIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHSRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGTHVEISESSLES---DSEADS-PPSEDLD--PADPPI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSSSSSSSGSSGGGS
SSS---SSSS----EEEEPEPEQAQAGEGDR--------ALLSPQYVVPDVDLWVPARQS
TSQP-WRGGAGARLGGPAASL----SPPKGSSASQGGSKEASITAAAPGE--ETSPAQAP
ARAHGP-VPRA--AQASHS----------ADTRPA--GAEKQALEGGSRLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-VDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTLASQRPAAVQTQADGL--REQLQQ---VRLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAAARDPPVHLLQAS-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVLLP-----SQLLVSSPVI
LQPRLP--HTPHGRP-APGPTV----SNVPLSGP--------------GAPAAAKP--GT
SGSWQEAGT-SAEDKRL--STTQA-------------------LPLAPAFTGAEGTAPAA
SQAPALGPDQISVSRPESGLGQSQAPAASR--------------------KQGLPEAPLF
LPAAPSPTPLPIQPLSLT-----HVGGPHVAASVPLPVTWVLTAQGLLPVPVPAVVSLPR
PAG-TPGPARLLATLLPPLTEARAAQGPRAP---------A-------------------
--------------NMDTEPEHSCRTDLSAPPTHAPSQSPAEVDGSVAL------VLGEA
QVAREIPEP----RRS------SQ---ADL--PEAEPP-----------WSGRLPALGGV
IPASEPGGTPGSPSGTQEPRGPLGLE------------------KPPLPQP--GPEKGAL
DLGLLSQEGEAATQ-QWLGGQQGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSAASRAGSES--EDED--L-LSELELA--DR--DGQPGCTTAT
--------------------------CPTQGAPDSGKCSAASCLDASNDLDVDDLDVLRT
RHARHSRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIQELE
RILYPGSSSVHFEVSESSLSS---DSEADS-LPDEDLETA--GAPI---L-EEEGSSEGS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGTKC
PKVKDGRSLPSYMYIGHFLK---PYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHGKQSRVSSELERQALEKQIKEAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGARSAEEIRKFWQSSEHPSISKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKTLKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILARKKQHLQRK-RGQRPRHSSQWSSSDSS-------SASE
DYGSGSGSGSSSSSDSEDSDVELEESLESSR--------ALTSQQYRVPDIDLWVPTRLI
TSQS-QREGT----GC-YPQHPAVSCCTQDAS--QNHHKEGSTTVSAAEK----NQLHVP
SETHST-VP------------------------------------RGDRFLHF--SDTHS
ASL---KDPACKSHT-------------------------------------------LM
KGRPRQPLLPNSRSGADPGNN--TAG--PHLRQLWHGTYQN----KQR--RKRQALHRRL
LRHRLLLAVIPWVGDINLACTQAPRRPATEQTKADSI--RMQLEC---ARLASTPVF---
----------TLLIQLLQIDTAGCMEVVRERKSQPPALLQSGTQNTQPHLPQAS-SNAKN
--STGCLLPSMP-GEQTAKRASHKGRPRLG-------------SCRTEAT---P--FQVP
VAAPRGLRPKPKTVSELLREKRLR-----ESHA-KKATQAL-GLN-----SQLLVSSPVI
LQPPLLPVP--HGSP-VVGPA----TSSVELSVPV--------------APVMVSS--SP
SGSWQVGGI-SATDKQP--PNL--Q-TI------SLNPSHKG-TQV-AAPAA----F---
-RSLALAPGQVPTGGHLSTLGQT--STTSQ--------------------KQSLPKVLPI
LRAAPSLTQLSVQP---------PASGQPLATKSSLPISWVLTTQKLLSVQVPAVVGLPQ
SVT-TPET----------------------------------------------------
----IGLQA-------KQL--P--------------------------------------
-------SPAKTPAF--------L---EQP--PASLDT----------------------
-----------------------------EPKGPQ--------GQEVPPT--PGPEKAAL
DLSLLSQESEAAIA-TWLKGCQGAFVP---PLGSRMPYHPPSLCSLRALSSLLLHKQDLE
QKASSLVASQAAGAQP--------DPKAGALQASLELVQRRFRDNPAYLLLKTRFLAIFS
LPAFLATLPPNSVPTTLSPDVAVVSESDSED------LGDLELKD--R--ARQLDCMACR
VQASPAAPDP--V----------------QRAPSPGEVSALSPLNASDG--LDDLDVLRT
RRARHSRR------

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIKELE
RILDPSSSGIHVEVSESSLDS---DSETDL-LPGEGLD--AADPPI---L-EEERWGEAS
ND-EDDPKDRALPEDPETCLQLNMVYQEVIREKLAEVSLLLAQNREQQEEIMWDLAGPKG
PKVQGSKSLPPNVYIGHFMK---PYFKDRVTGVGPPANEETREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSRVSSEPERQALGKQIQEAEKEVQD
INQLPEETLLGNRLDNHDWEKISNVNFEGGRGAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVER
LKAIAASHGHLEWQKVAEELGTRRSAFQCLQTFQRHNTALRRREWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYF

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWTLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKVMIGKRQGLQRR--RRRPRRSVRWSSSSSSSGGDT-SSSGG
GST---SSSSSSGSGSEESEAELQQAQEGGR--------ELPSPQYVVPDMDLWVPARHS
TGPA-WRAGPGGRPGRPAASL----GPPKGPGATQGSREETSAPTSAPHE--QLGPSQAP
SGVHST-ALRG--VQDSRA----------ADTLLA--RSEELALEDGSRLLKVPLETV-L
RVL---RTNTATRSR-------------------------------------------TL
KEKLKQPPLPSSPLGAS-SGDS-AAR--SHVRQLWHGTFQN----GRR--RWRHALHQRL
LDRRLLLAVTPWVGDVILPCTPAPRRPAVAQTRADGL--GKQLQH---ARLASTPVF---
----------TLFIQLFQIDTAGCMEVVRERKVQPPGLLQAGTQDPPPRPVQAL-SRAPS
--TPGCPLPSVTAQKAAKP----------AG-------------RRT-----EYATPPVP
PPALSGPRPKPKTVSELLREKRLR-----EARA-RKAAQGPTVLT-----PRLLLSSPVI
LQPALP--PAPHGPP-ALGPAL----SNPAASGP--------------GGPAAASL--GT
SASWQGAGT-SAKDEGS--STLQT-------------------LS-----------LAAA
SGTPTLGPGQVTGSCHPNSLGQSQVPATSR--------------------KQGLPEALPF
LPAAPSPAQPPIQPLSLT-----HRAGPHVAANVPLPVTWVLTAQGLLPVSVPAVVGLPR
PAG-TPDSTGLPVTLLPPLAETRAAQGPRAPGLSCPGQPQT-------------------
--------------SVDVGPDSSPGTGPSTPATCPSSQRPADVDGD--V-----------
-----ACVA----RTS------PQ---ADH--PEAEPL-----------PPSPLPACGVA
GPGSDPGGTPG---------PPSGTR------------------EPRGPQP--GHEKGSL
DLGLLSHKSEAATQ-EWLRGQGGVCVP---PLGSRLPYQPPALCSLRALSGLLLRKKALE
DKATSLVANG----AA--------EPRAGALQAALGLVRAQLQDNPAYLLLKARFLAAFA
LPALLATLPPCGVPTTLSAATGVGSES--EDEG--L--DEPELT--SA--RSPDQVR---
--------------------------SASSPAPGPGEGSAPSCPDTSADL-DTDLHVLRT
RRARHARKRRRLL-

------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------KL
PRPKRARVCPRTSFVGHFMK---PYFKDKATGIGPPANEETREKVAQGIKSFEELLVTKW
KTREKTLLRNSVMSDRLQRLLQPKLLKLEYLNRKLEKIMNKMDRQIVEKQIAETEKEIED
INQLPSERLLGDRMDEHDWEKISNINFEGTRNAVELRKFWQNHEHPSINKA

PF00249 // ENSGT00390000001038_0_Domain_2 (412, 456)

EWGEKEIEK
LKEVAAKHSYLNWQKIAEELGTNRSPFQCLQKYQTYNKDFKRKEWTKEEDQMLTQLVGEM
RVGSHIPYKKI--AYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGFWTPEEDAKLLRAVAKYGER
DWFKIREEVPGRSDVQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

KRLHVNLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 618)

KGKWSPSEEEKLIELVEKHGVGHWTK
IAAELPQRTGSQCLS-KWKIMIGDKKGEDRH-QKKK-----------KQRN----RKRQR
KSRRGPRGGQHVPSSSEESEIEFTDNSEEEEEKKSDQEKEPAVPSYTVPNIDLWIPSVM-
--IA-CQGKRQKGFGNGASSHHSK----------------PVLP-SSF-FLYLIARLGLR
MLG---------ALVQRLLPL--QNQSFHQFQPPSP---HFIFF-------TVAHSPFTQ
DPG---SGNIFFCKE-------------------------------------------K-
---LKKPRLPTSSVMPQVSAG--MSG--DQVLQVWENTVEKRLQRLKV--GLRRNIRRSN
LDRRLLLAVTPWVGNVTLPRFQNSRKGLVLQTKASSLIKKRPLQT---VLLTSTPMF---
----------TLFIQLFQIDADGCMKVIQERKANQVEVVQVEPGNPEQLRHLFC-R---D
--ELGFLHEQAPPP--L-KKGEVSGMSDS-------LPHRV--SCYLQSE--LCSLPPP-
---------------------------------------RKMMIP-------MFPVFLGI
LQFPGHFRY--PSHS----------------------TYFLDFLGSLSRMRILTPWLQHL
SVLWDGKSL-GVSSRRP--VSVAATSSLELAER------KEGGTVLSLSPSA--------
---EHSCGGH-------DCLWQNQLGNP--------------------------------
----PHGWGLRRGPSGFYCMLLSFFP------------------------------GCQP
-QK-DPAKGNSRRRSAPRVEDGQLERDGKVTAQAGAPSAQKEN-----------------
--EPVRCTCVSQSHMPKDL-----------------------------------------
-PA-TQSAPTTAPLPARVGKDRPI---APR--PEATPPPG--------------------
-------GHPA----PAD--------PPPRGHPPPG-----GDRPPGP----VAPDKNKL
DLTLISLEEEAVVR-EWMKGKRGVHVP---PLKNNLPYLPPSVYNLKTLSGLLREKKNLE
RSAASLVAGDGGPAGS--------ELSPEGLEAIRALVRERLKDNPAYLLLKARFLAAFT
LPAFLATLPPPGVPTTLSRRPEESEEEDEDDG-----EEEEKD-----------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDVDAEREKIAKEIAELE
RILDPSSSSIGVGVSESGLAL---DSDADS-LPEEDSD--AADSPV---S-EEERWGEAS
NG-EDDPKEKNLPEDPETCLQLNMVYQEVIQERLAEVSLLLAQNREQQEEIMSDLAGSKG
PKVKDGKSLPPNLYIGHFMK---PYFKDRVTGVGPPANEETREKAAQGIKAFEELLVTKW
KNWEKALLRRSVVSDRLQRLLQPKLLKLEYLHQKQSRVTNEAERQVLEKQSREAETEAQD
IRQLPEEALLGNRLDNHDWEKISNVNFEGSRSAEEIRKFWQNFEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGQEVDQ
LKAIAAKHGHLQWQTIAKELGTNRSAFQCLQKYQQHNKALKRKEWTREEDRL

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLKKGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYLRRLHFSLKKGRWNASEEEKLVELIEKYGVGHWAK
IASELPHRTGSQCLS-KWKIMVRKKQSRGRR--RRRPLRSVRWSSSSGDTSSEDISGEGG
S---------GNSEDS--EPEEAPEAGTGGQ--------APPSTQYTVPDMDLWVPARQS
AGEP-CGEGARGWPGHHASPS----SPPQGSSKAQDGSGAIHPTASAPTE--EVGRVHAP
SGTHSTHSAGG--VGHPDL----------VDTHPL--SSEEPTNKPHI---CNSGSHL-L
QVL---RTNRAYWCQ--------------------------------------------M
VEKLRQSCLLSSSLGASPGDSS-VAR--PRVQQLWHRTTRN----RRR--WRGQALQRRL
LEYQLLMAMSSWVGDV-LPCTS--RRPATVHTQADGL--RKQLQD---AQLTSTPVF---
----------TLFIQLFQIDTTGCMEVVRERKAQSSALLQTSAQDPGPGLLQMS-SSTQN
--ATGRSFCSLPSREPAKQSTSHKGSRGWQP-------------CRA------KSSPQAP
LPAPSGPRPKPKTVSELLREKRLR-----EARA-QKATEGTVALT------PLLLSSPLI
LQPSLP--QTPHHPS-TSGLAV----TDMVLSGP--------------GAPAVTGL--R-
--------T-SAKDERP--STLPV-------------------VACTL---ASTEAVPAA
SRAPVLGPSQVSVNGHQDGLGQSQAPATSR--------------------KQGLPEAPLF
LPAAPSPTQLPVQPLSLTPALGMHKEGPHVVATTPLPVTWVLTAQGLLSV--PAVVGLRG
PAGGTSDPKGLSVTLSPTLPGMQVGRDPRPSGLSHPWQPPA-------------------
--------------NVDTDSDPPSRTDLLTIPMLCQSQNSVEMGGDVAHASGGPAFPGEA
QVVQEIAMPRIPSQAT------LL---ADH--PEAKPC-----------RSSQPPMQAE-
---SGPGETPGSPRPGGL-------------------PGPLGLERPPPPRP--RPERGAL
DLDLLSQESEAAVQ-EWLRGKQGVCVP---PLGSRLPYQPPALCSLRALSGLLLHKKTLE
QRATSLMPSGAAG----------------ALQASLGQVRRQLQDSPAYLLLKARFLAAFT
LPALLATLSPHGVPTTLSLATRADPESEDD-------LGELELT--------------CG
PQAGPAAT------------------IPVQGAPDPGQS-----LDG-----CDSLDVRRT
RHAWHARKRQRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITKEIKELE
RILDPCSSSINVEVSDSSLES---DSDADS-LPDEDSD--TAGPPI---S-EEERWGEVS
ND-EDDAKEKTLPEDPETCLQLNMVYQEVIQEKLAEVGLLLAQNREQQEGVMWDLAGSKG
PKVKDGKSLPPNLYIGHFMK---PYFKDRVTGVGPPANEDALDNAAQGINAFEALLVTR-
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRVTSEAERLVLEKQSREAEKEIQE
INQLPEEALLGSRLDAHDWEKISNVSFEGSRSAGEIQRFWQNWEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQEWSRQEVGQ
LKAIAAQHGHLEWQKIAEELGTGRSAFQCLQKLQQHSKASRRKEWTEQEDRMLTQLVQEM
RVGSHIPYRKI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGFWAPEEDAKLLRAVAKYGEQ
DWFKIRAEVPGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWNPKEEEKLTELIEKHGVGHWAK
IASELPHRSGSQCLS-KWKIMVRKQQRRGRG--RRRPLRTVRWSSSSGSSGSGDSGRDSS
GSS---SS--GSSKEDEPEPEEAAEAQEGGQ--------VLPSARHSVPDVDLWIPTRQS
ADRL-RGRGAGGS----ATSS----SPPAGFRVARGGST----AASAPTE--KAGQARAP
SATHSA-AGTD--VGYPRS----------ADTQPS--SSEGPADESGVRLPKGPPETV-L
QVL---RTDTDTDTG--C---------------------------------------QPL
EEEPRQP-CPGSAQGTGPGGSV-LAR--PRVRQ--------------W--PRGHALHRRP
LERRLLMAVSPWVGDV-LPCLP--RRPAVVHTRADSI--RTRLQN---ARLASTPAF---
----------ALFIQLFQINTAGCMEVVRERKALLATLPQSGSQEPLQRPLQVP-SSARS
--TTGGLLQNVPAREAAK-STLCRGSRGLQA-------------CWP------EPTPQAP
PPASCGPRPKPKTVSELLREKRLR-----EARA-SKAAQGPAALP-----PQLLVSSPVV
LQPALP--LVSPSPP-ATGPAV----SESTLSGP--------------GAPAAAGP--ST
SGSWP-----SAEDRGT--PVLQA-------------------LAFLPASTVAEGTAPAA
SRTPALGPSQLPMSCHLTGLGQSQAPATTR--------------------KQGLPEALPF
LPAAPSPAQLPVQPLSLT-----HPRGPRVAASTPLPVTWVLTTQGLLPVPVPAVAGLSR
PAE-TLDPKGLLVTLSPSLTETQEGQGL--------------------------------
-------------ANIDVEPDPSSRTDLMTLSTP-AASSPAEVDGDMAR------APGEA
QAAGEIAS-----KTA------LV---ADH--PEAEPT-----------WPSQLPTHGSA
YPGSGPGGTLVSRSDPGKTRGP------------------LDSERHPPPRL--GPEKGAL
DLGLVSQESEGAVR-AWLQGQRGVCVP---PLRSRLPYQPPALCSLRALAGLLLHKKALE
HKAASLAQRA-----------------ARTPQASPGLLQGRLGDSPAYLLLKARFLAAFT
LPALLATLPPRGVPTTLSAAARDHPEG--EQED----LGELELS--DG--DGQLGCWTAS
--------------------------SPVQGVPDPGEGSAPSCLDE-----SGDFDVLRT
RHSRHARKRRRLV-

------------------------------------------------------------
----------------------------------RPRRQAEAMDIDAEREKITQEIQELE
RILYPGSSSVHFEVSESSLSS---DSEADS-LPDEDLETT--GAPI---L-EEEGSSESS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGTKC
PKVKDGRSLPSYMYIGHFLK---PYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEIQD
INQLPEEALLGSRLDSHDWEKISNINFEGARSAEEIRKFWQSSEHPSISKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKTLKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WTPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILARKKQHLQRK-RGQRLRHSSQWSSSGSS----SSSSGSE
DYGSSSGSGGSSSSGSENSDVELEESLENSR--------ALTPQQYRVPDIDLWVPTRLI
TSQS-QREGK----GC-YPQHPAVSCCTQDAS--QNHHKEGSTTVSAAEK----NQLQVP
YETHSS-VP------------------------------------RGDQFLHF--LDTHS
ASL---KDPACKSHT-------------------------------------------LM
KERPKQPLLPNSRSGSDPGNN--TAG--PHLRQLWHGTYQN----KQR--RKRQALHRRL
LKHRLLLAVIPWVGDINLACTQAPRRPTTVQTKADSI--RMQLEC---ARLASTPVF---
----------TLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRNTQPHLLQAS-SNAKN
--NTGCL-PSMT-GKQTAKRASHKGRPRLV-------------SCRTEAT---P--FQVP
VAAPRGLRPKPKTVSELLREKRLR-----ESHA-KKATQAL-GLN-----SQLLVSSPVI
LQPPLLPVP--HGSP-VVGPV----TSSVELSVPV--------------APVMVSS--SP
SGSWPVGGI-SATDKQP--PNL--Q-TI------SLNPSHKG-TQV-AAPAA----F---
-RSLALAPGQVPTGGHLSTLGQT--STTSQ--------------------KQSLPKVLPI
LRAAPSLTQLSVQP---------PASGQPLATKSSLPVNWVLTTQKLLSVQVPAVVGLPQ
SVM-TPET----------------------------------------------------
----IGLQA-------KQL--P--------------------------------------
-------SPAKTPAF--------L---EQP--PASTDT----------------------
-----------------------------EPKGPQ--------GQEIPPT--PGPEKAAL
DLSLLSQESEAAII-TWLKGCQGAFVP---PLGSRMPYHPPSLCSLRALSSLLLHKQDLE
QKASSLAARQAAGAQP--------DPKAGALQASLELVQRQFRDNPAYLLLKTRFLAIFS
LPAFLATLPPNSVPTTLSPDVAVVSESDSED------LGDLELKD--R--ARQLDCMACR
VQASPAAPDP--V----------------QRAPSPGEVSAPSPLDASDG--LDDLNVLRT
RRARHSRR------

------------------------------------------------------------
---------------------------------RPRRSGAEIMDIDAEREKITQEIQELE
RILYPGSSGVHLEVSESSLGS---DSEADS-LPHEDLE--TADVPV---LVTEGRWGEAS
ND-EEDPKDRALPEDPETCLQLNMVYQEVILEKLAEISQLLAENQEQQEELLFDLAGAKC
PKVKDGKSLPSNMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRVSSESERQALERQVREAEKEIQD
INCLPEEALLGNRLDSHDWEKIANVSFEGGRSAEEIRKFWQSSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWGAEEVEQ
LRAIAAAHGHLEWHLVAEELGTRRSAFQCLQKFQQYNKALRRREWTEDEDRVLTQLVQEM
RVGSHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKKGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WTPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEEQLIELIEKYGVGESWR
L--------SSRCLK-KRC-------L--PRRRGRRPRPSSQWSSSSSSSNSGSDGYSS-
-----------SSSS---SEDSEAEPLEGGR--------VLLPPQYTVPHIDLWVPTRQS
TSLP-QRQGAGCYPEHPAASS----CPPDGSDTTHSHQKAVSTTASAL-D--AVIQAQVP
YETHST-VPRG--AQDLHL----------SDTHPA--SVEDPSCKS--------------
-----------------H---------------------------------------TLV
KERLRKPPLPNLPPGPGP-GDS-TIE--PCLQRLWRGTFQN----RQR--RKRQALHRRL
LKHRLLLAVIPWVGDITLPCTQAPRRLAAAQTQADII--RMQLEC---AHLASTPVF---
----------TLFIQLLQIDTAGCMEVVRERKTQPPTAHQPGTQGPQPHLQQVA-STKDK
NEDKCSLFPSMPAEHTVK-RAGHKGRPRLGS-------------CRT-----ESTSSPVP
TLAPQGPRPKPKTVSELLFEKRLR-----ESRA-RKATQAL---N-----SQLLVSSTLL
LQAPLL--PAPQGLP-VAGPAA----SNMELSGP--------------LAPVVISS--SP
SGSWQVAET-SAKDKQP--LNLQT-------------------LPLTPLHRGTQAAAPAA
FRSLAPAPEQAPVTCPLSTLGQSQAPATSQ--------------------KQSLPKALPL
FPAAPGPTRLPVQPLSGH----------PLAAGARLPISWVLTTQKLLPMPVATVVNFPQ
PVK-TPDPPLPPT---------K--------TPVCPGHPPF-------------------
------------------------------------------------------------
------------------------------------------------------------
---------------STEPRGPQDLE--------------------RPLTS--EPEKKAL
DLNLISQESEAAIR-AWLRGCQGASVP---PLGTKLPYLPPALCSLRALSNLLLHKKALE
HKVSSLVDGKAAG----------------ALQASLGLVRRQLHDNPAYLLLKTRFLAVFS
LPALLATLPPNSVPTTLSSATAVSSES--DSED--L-MGDLEPK--DK--ARKLECMACG
MQASPVAT------------------DPMQETPGPGEDSTPSHPDA-----SDDLDVLQT
RHARHARK------

------------------------------------------------------------
------------------------------------------MDIDAERERITKEIKELE
RILDPSSSGVPMEVSESSLDS---DSEADS-LPGEDLD--TADPLV---L-EEERWAEGS
ND-EDDPRDKTLPEDPETCLQLNMVYQEVIREKLAEVSLLLAQNREQQEEIMWDLAGPKG
PKVKDSKSLPPNMYIGHFMK---PYFKDKVTGVGPPANEETREKAAQGIKAFEELLVTKW
KSWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSRVCSELERQALEKQIREAEKEVKG
INQLPEEDLLGDRLDSHDWEKISNVNFEGGRGAEEIRKFWQNSEHPSINKQEWNGEEVEQ
LKVIAASHGHLEWQKVAEELGTGRSAFQCLQKFQQHNKALKRKAWTEEEDRMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

RGVWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHCSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNIKEEEQLLELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKVMTGKKQSLQRR--RRIPRRHPQWSSSSSSSSGETSSG---
--------SSRDTSSSEESEVELEQAQECGS--------VPLSPQYMVPDMDLWVPARQS
TSQA-WRGRTGSCPGHLAASP----SHPQGSSAAQAGGKET------PGK--ELSQAQAP
SRTHST-ALRG--VQCSHL----------ADPDPA--SSEGLALKDGKLLKKVPLQTV-L
RVL---RTNTATWSR-------------------------------------------TL
KEKLRQPLLPSSSLGASP-GNT-MAR--SHMQQLWHGTFQN----GRQ--RWRHALHRRL
LDRRLLLAVTPWVGDVVLPCVQPPRTTAATQTHADGL--RRQLQH---MRLASTPVF---
----------TLFIQLLQIDTAGCMEVVRERKVQPPGLLQAGPQDPLPHLLQAP-PSAQS
--TSGCLLPDATVQKATKTA----THRGLGS-------------CRA-----VCAPHQVS
PPTPCGPRPKPKTVSELLREKRLQ-----EARA-RKAAQGPTGLP-----PRLLLSPPVV
LQAPLL--PAPHGPS-ASSSVI----SNIAPSGL--------------GIPAVASL--IT
SASQQGVGT-AAKDQGS--PTLQT-------------------LPH-----------GVS
SVAPALGPGQVPMNCHLNGLGQSQAPATSQ--------------------KQGLPEALPF
LPAAPSPTQLPIQPLSLT-----HRGGPQVAANVPLPVSWVLTAQGLLPVSMPAVVGFPR
PAG-TPDPSGVPVTVLPPLPETCTTQGPRA------------------------------
--------------SMDTRPDLSSSTGPLASPTQSLSQSPAEVDGDMAC-----------
-------VP----RTL------PR---ADH--PEAGTP-----------QSSQLPVCAGS
GPRSEPGGLLG---------SPSGTR------------------EPKGPQP--GLEKGFL
DLSLISQDSEVATR-EWLRGQHGVCVP---PLGSRLPYQPPALCSLRALCGLLLHKKALE
HKATSLVAGGAARD----------EPEAETLQASLELVRRQLWDNPAYLLLKARFLAAFT
FPAFLATLSPHGVPTTLSAATGVDSES--EDED--L--EQAEPT--DK--HGQGGSVAPA
--------------------------IPVQQALNSGEGSAPPCLDASVDLDVDDLDVLRT
RHARHTRKRRRLL-

------------------------------------------------------------
------------------------------------------LDLEAERERIRREIQQLE
RSLQPGGTDLQLSD--CSLSS---GTAP---RGSGQR-RER-RSAR---S-VEVEGGDSS
DDDDDDDDIESLPQDPETCLQMNHVYQDVIKEKIEEVELLVAQNREQQKEIICELHGPKR
AKAGDGRNLRTNVFLGHFMK---PYFKDKITGIGPPSNEDAKEKAAQGIKSFEQLHSAKW
KTAEKTLLQKSVVSDRLQRLLQPKLLKLSYWNQKLEKIKTDIEKDTLVKQIKDLEQEIEA
INQLPESDLIGDRFDEHDWDKISNIHFDGQRRSEELRKFWQNWEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KNEWTEEELER
LKQIAAEHNYLDWQAIAQELGTNRTPFQCLQKYQV

ENSGT00390000001038_0_Linker_2_3 (456, 462)

YNKDLK

PF00249 // ENSGT00390000001038_0_Domain_3 (462, 511)

KKEWTKEEDQMLLELVQEM
RVGSHIPYKKI--AYYMEGRDSAQLIYRWT

ENSGT00390000001038_0_Linker_3_4 (511, 519)

KSVDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGPWTPEEDAMLMAAVNKYGEK
DWYKIRTEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

KALHWDVK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGKWSLQEEEQLIELVEKHGLGHWSK
IASELPHRTNAQCQS-KWKFM---------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDIDAEREKISKEIKELE
RILDPSSSSIPVDISESSLDS---DSDAES-LPPEDLE--VAGPRV---L-AEERWGEAS
DD-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
PRVKDGQGLAPHMYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLRQKQSQVSSEPERQALEEQARCAEQEIQD
INQLPEEALLGNRLDPHDWEKISKINFEGGRSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSVEEVGQ
LMAIAATHGHLQWQLVAEELGTGRSAFQCLQQFQQHNRALKRRQWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 520)

LTQLVQQM
RLGSHVPYRKI--VYYMEGRDSMQLIYRWTKSLDPNLRK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHVSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 620)

KGRWNAEEEAQLMELIEKHGVGHWAK
IASELPNRSGSQCLS-KWKSMVGKKQRVQRR-RRRRLRPSIQWSSSSSGGSSEDSDGICS
GSN-------SSSGDSEDSEAEPEEPQEAGS--------VPPSPQYVVPNMDLWLPARQS
TSQD----------------------------------PEAAPTALAPGE--TTRQAQAS
SGVHSTHS---------------------ADSPRTS---------LGQRG----------
------ALNTSTP-------------------------------------RSPHTSSCPQ
KERLRQLPLPGSPPGPGP-GDS-EDG--PHLRQLWHGTFQN----RQQ--RRRRALHRRL
LERRLLLAVTPWVGDVTLPCVQAPQRPEVARIRGT------QLER---VHLASTPVF---
----------TLCMQLMQIDTAGCMEVVRERKTQLPTPPLPGAQGPPPHPLQVAGMRGEG
---------------------TDSRSTELKP-------------CQA-----KSPSARAP
MLAPQGPRPRPKTVSQLLREKRLR-----EAPA-RKATLGPVALA-----PQLLISSSVV
LQQPLP--PARQSPP-ALSPTI----SSTGLSGS--------------VAPTAAST--GA
SGSQQELGT-SAKDEDQRLPALRA-------------------LSLAP------------
----TLGSGQVPAGRPLSSLGQSQAPTTTR--------------------KPGLPEVPRF
LPAAPSPAQLPMQPLGLTPA---------LTTSIPLPVTWVLTAQGLLPVQVPAVLGLPK
QGE-MPAPRQVPAPPPPP-TETPAPT----------------------------------
-------------------HQLLASVDPSGPPACPLPQTCTEACADL-------GVLGEA
QVARPASVP----RMT------SQ---ADS--PETGAL-----------RPGQLPAGDGS
SPRREPGGVAVAG-----------------------------------------------
------------------------------------------------------------
-------------------------SGPLAWQASLELVRRQLQDNPAYLLLKARFLAVFT
LPALLATLPPDGVPTTLSAATRSGPDDE----D----LSGLEPEDGDR--DERPHCTPHG
TQAGSAPR------------------SPVQGTPSSGEG-LVSCLDA-----SDDLDVLRT
RHGRHARK------

MPRVGEAVSLPFAPGMCFSGIFSASALYYQLSFQLPYPFSLCWRLFLKKRPPVCPAGVY-
AVSDPCQVLFWLEGEQGQMEPFPSSPLPVLSRCCVICQQVEVMDIDAEREKLSKEIKELE
RILDPSSSGIPVDVSESSLES---DSDGES-LPAEDLD--IASPPV---L-AKERWDGTR
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
PRVKDGKGLPPHMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRRSVVSDRLQRLLQPKLLKLEYLRQKQSRISSEPERQALEEQARCAEQEIQD
INQLPEEALLGNRMDSHDWEKISKVNFEGARSAEEIQKFWQSSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSTEEVEQ
LMAIAAAHGHLHWQLVAEELGTGRSAFQCLQKFQQHNKALKRREWTEEEDRMLTQLVQQM
RVGSHVPYRRI--VYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGLWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHVSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNAEEEEQLIELIEKHGVGHWAK
IASELPHRSGSQCLS-KWKIMAGKKQRVR----RRRPRPRVQWSSSSSSGGGSSSSGSGS
G-SSGDSDGGPSSSSSEDSEGELEEPQQAGS--------MPPSPQYVVPNMDLWVPARQS
ATQK----------------------------------PEAARTALAPRV--EIRQAQGS
SRVYGT-----------HA----------ADTQLT--SLEEPSCEGEQHLLKVPLETV-R
RVL---RTNTTAWRH-------------------------------------------KL
KERLRQPPLPGSPPGPGP-GDS-EAG--PHLRQLWRGTFRN----RHQ--HHRRILHRRL
LEHRLLLAMTPWVGDVTLPCTQAPQRPVVARTRADGV--RTQLEQ---VRLASTPVF---
----------TLCLQLLQIDTAGCMEVVRERKAQLPP------PGPQPRPLQVP-SGAPA
--PPGCQPQHVSSQDATKS--LCSGSTELKS-------------SQA-----KSTSARAP
APAPQGPRPRPKTVSQLLREKRLH-----EAPA-RKATLGPVALA-----PQ-LLISPVV
LQQPLP--PARQGPP-AAGPVR----SSPGLSGP--------------MTPTAAGT--NA
SGSQQEVGA-SAKAQCP--PTLQA-------------------LQLAP------------
----TLGSGQAPTGCPSSSLGQSQAPATMR--------------------KQGLPEAPAF
LPAAPSPALLPTQPLSLTPT---------LATSIPLPVSWVLTAQGLLPVQVPAVLGLPT
QRE-MLNPPKMPTLLPPSPTMTPV-------PPHHDSQPPA-------------------
--------------TVDTEAAPESRTDPSGPPTCCTPLSSTEVSGEE------------A
QVARQAPVP----RTS------IP---ADS--PDTG--------------ASKLPACGGP
SPSSDLGGTEV-------PSRPLGLE--------------------RSSLP--GSEKRAL
DLGLLCLESEAATW-EWVRGRQGVCVP---PLQTRLPYQPPALCSLRTLSSLLLRRAALE
HKAASLVADRAAG--------------PGAWRASLELVRRQLQDNPAYLLLKARFLAVFT
LPALLATLPPSGVPTTVSAAPRPSPET--TDED--F-SSELESEDGDR--HEWLGCTAHG
TQAGPEPG------------------SPVQGAPDSGKGS-VSCLD------ASDLDVLRT
RHGRHVRKRRRQL-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHMEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLDYLHQKQSKVSNEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEEEPEPEPEQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHAASL----SPPKGSSASQGGSKEASATAVAPGE--ETSAVQAP
ATAHSP-VPRA--AQASHS----------ADTHPV--GPEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPGHLLQAP-SSAQS
--TPGHLLPNVPAQEASK-SASHKGSRRRAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPAAAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSRVSVSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAVPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-TPGPTGLVATLLPPLTEA---QGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTVPPAPPTHAASQSPAEVDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPP-----------LPRRLPPPGGV
IPASEPGGTLGSPSGTQEPKGTLDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEAEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLRDNPAYLLLRARFLAAFT
LPALLATLAPHGIRTTLSAASIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHSRKRRRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKISQEIKELE
RILDPSSSSIPEDVSESSLDS---DSDAES-LPAEDLN--VAGPPG---L-AEERWGEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
TRVKDSKGLPAHMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSRVSGSPERQALEEQARCAEQEIQD
INQLPEEALLGSRLDPHDWEKISKINFEGGRSAEEIQKFWQSSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSEEEMGQ
LMAIAAAHGHLQWQLVAEELGTGRSAFQCLQKFQQHNKALKRSEWTVEEDRMLTQLVQQM
RVGSHVPYRKI--VYYMEGRDSMQLIYRWTKSLDPNLRK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHGSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWSAKEEEQLTELIEKHGVGHWAK
IASELPNRSGSQCLS-KWKIMVGKKQRVQRR---RRPRPRVWWSSSSSGSGSSSGDSDG-
---------SHSSSSREDSEVELEEPQEAGS--------MPPSLQYVVPDMDLWVPARQS
ASQK----------------------------------PEASPMALAPGE--EMRQAQVS
SRVHGT-----------HS----------ADAPRT--SLEEPAREGGQRLLKVPLELV-Q
GVL---RTSTAARSYTLVRAWAHAHSRDLYPPVPLSCLPRPRQWGHWMAPRLGAXXXXXX
XXXXXXLPLPGSPPGPGP-GDS-KAGPHPHLRQLWHGTLQN----RQQ--RRRRALHRRF
LEHRLLLAVAPWVGDVTLPCTQARQRPVGARIRADGI--RTQLEQ---VHLASTPVF---
----------TLCMQLLQIDAAGCMEVVRERKAQLPTLPPPGAQGPPPHPLQVP-SGAST
--PPGCHPHHAPAQNVTKST--DSGSAGLRS------------SCPA-----KSTPAQAP
MPAPQGPRPRPKTVSQLLREKRLR-----EAPA-RKGPPGPGTLA-----PQL-LISPVV
LQQPLL--PARQGPP-AVAPAV----AGTGLSGS-----------------TAAST--GT
AGSWQAVGT-SAKEKDQRPPAARA-------------------LPL--------------
--APTLGSGQVPADCPSSSPGQSQAPTTTR--------------------KQGLPEVPAF
LPAAPSPTQLPMQPLSLTPA---------VAASLPLSVTWVLTAQGLLPVQVPAVLGPPK
LGP-MPAPAKRPAPPPRPPTE----------TPAPPGQPPA-------------------
--------------SVGTEAAPSSSTDRSGPPACPPPKTCAGAHGADP------RVLGEA
QVAQQASVP----RMS------SQ---ANH--PEMKAP-----------QPGQPPTGDGP
SPRSGPGGTTAASS------GALGLE--------------------RPPLP--GPEKQAL
DLALVCLDSEVATWEPWLRGRRGVCVP---PLETRLPYQPPALCTLRALSSLLLRRAALE
RKASSLASDGAAG--------------PGAWQVSLEWVRRQLQDNPAYLLLKARFLAVFT
LPALLATLPPNGIPTTLSAATRTGPET--EDED--L-LSEPEPGDGDR--HKRPCCTSHG
MQARPVPR------------------SPEQGTLESSEG-LVSCPDA-----SDDLDVLRT
RHSRHARKRRQQL-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSTGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EEDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNELEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGVKQGLRRR--RRRARHSIRWSPAAAAAAVAVAAAEGA
AAA------A----VRRRCRAEQAEAEEGDR--------ALRVPRYV------------S
TSQPWRRGGPGACWEAPRCLP----QPSQGSSASQGGSKEASATAAAPGE--ETSGSAA-
-----L-SLRA--AQASHS----------ADTHPV--GAEKQALEVGP--GPVMTVPV-G
DRL---ARGPRCRLL-------------------------------------------FQ
KEQLRHRPCPTSSPGVSS-GDS-VAA--VPCA---LAGTQS----GQR--RWRHALHRRL
LNRKLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQR---ARLASTPVF---
----------TLFTQLLQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQVP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEK--------REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHSRP-ALGPTV----SNVPLSGH--------------GTPAAAKP--GT
SGSWQEAGT-SAKDDRL--STIQA-------------------LPLAPAFTGTEGTAPAA
SRAPGLDPSQVSVSCPGSGLGQSQAPTASQ--------------------RQSLPEVSPF
LPAAPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPV--PAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTDPPAPPTHAASQSPAEVDDSVAV------VPGEA
QVAREIPAP----RTS------SQ---TDP--PEAEPA-----------WPRRLPPLSGV
IPASEPGGTLGSPSGTQEPKRPLDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEGEVATQ-QWLGGQRGVRVH---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLATFT
LPALLATLTPHGIRTTLSAASIASSESEDEDL-----LSELELA--DR--DRQPGCTAAT
--------------------------CHIQGPPDSGRCSASSCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

----------MLAPD------------------------KTEHKEV----LGVQKAGRLQ
HQGWACASVSFQRETW---QRGIGALSCTLILCGVFWRQVEVMDIDAEREKISQEIKELE
RILDPSSSSIPEDVSESSLDS---DSDAES-LPAEDLN--VAGPPG---L-AEERWGEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
TRVKDSKGLPAHMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSRVSGSPERQALEEQARCAEQEIQD
INQLPEEALLGSRLDPHDWEKISKINFEGGRSAEEIQKFWQSSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSEEEMGQ
LMAIAAAHGHLQWQLVAEELGTGRSAFQCLQKFQQHNKALKRSEWTVEEDRMLTQLVQQM
RVGSHVPYRKI--VYYMEGRDSMQLIYRWTKSLDPNLRK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHGSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWSAKEEEQLTELIEKHGVGHWAK
IASELPNRSGSQCLS-KWKIMVGKKQRVQRR---RRPRPRVWWSSSSSGSGSSSGDSDGS
HSSSGDSDGSHSSSSSEDSEVELEEPQEAGS--------VPPSLQYVVPDMDLWVPARQS
ASQK----------------------------------PEASPMALAPGE--EMRQAQVS
SRVHGT-----------HS----------ADAPRT--SLEEPAREGGQRLLKVPLELV-Q
GVL---RTSTAARSYTLER-----------------------------------------
---LRQLPLPGSPPGPGP-GDS-KAGPHPHLRQLWHGTLQN----RQQ--RRRRALHRRF
LEHRLLLAVAPWVGDVTLPCTQARQRPVGARIRADGI--RTQLEQ---VHLASTPVF---
----------TLCMQLLQIDAAGCMEVVRERKAQLPTLPPPGAQGPPPHPLQVP-SGAST
--PPGCHPHHAPAQNVTKST--DSGSAGLRS------------SCPA-----KSTPAQAP
MPAPQGPRPRPKTVSQLLREKRLR-----EAPA-RKAPPGPGTLA-----PQL-LISPVV
LQQPLL--PARQGPP-AVAPAV----AGTGLSGS-----------------TAAST--GT
AGSWQAVGT-SAKEKDQRPPAARA-------------------LPL--------------
--APTLGSGQVPADCPSSSPGQSQAPTTTR--------------------KQGLPEVPAF
LPAAPSPTQLPMQPLSLTPA---------VAASLPLSVTWVLTAQGLLPVQVPAVLGPPK
LGP-MPAPAKRPAPPPRPPTE----------TPAPPGQPPA-------------------
--------------SVGTEAAPSSSTDRSGPPACPPPKTCAGAHGADP------RVLGEA
QVAQQASVP----RMS------SQ---ANH--PEMKAP-----------QPGQPPTGDGP
SPRSGPGGTTAASS------GALGLE--------------------RPPLP--GPEKQAL
DLALVCLDSEVATWEPWLRGRRGVCVP---PLETRLPYQPPALCTLRALSSLLLRRAALE
RKASSLASDGAAG--------------PGAWQASLEWVRRQLQDNPAYLLLKARFLAVFT
LPALLATLPPNGIPTTLSAATRTGPET--EDED--L-LSEPEPGDGDR--HKRPCCTSHG
MQARPVPR------------------SPEQGTLESSEG-LVSCPDA-----SDDLDVLRT
RHSRHARKRRQQL-

------------------------------------------------------------
------------------------------------------MDLVAEREKITKQIKNLE
KILDPNIATIEVVVSDSNLDSTS---EAGEPLIEENFH-VVKDPELKQEGKLEESWGES-
-D-EDDSKDQALPKDPETCLQLNMVYQEVLQEKIAEIDLLLAQNKEQQEEVMWDLAGSKA
SKTKDGKSLPSNVFVGHFMK---PYFKDKVTGIGPPANEDTREKATQGIKSFEELIVTKW
KTWEKTLLRKSVISDHLQRLLQPKLLKLEYLNQKLDKVSDSVEKQILEKQIKNTEKEIED
INQLPEESLLGDRLDERDWEKISNINFEGSRSADEIRKFWQNCEHPSINKQAWVEEETKR
LKEIAAKHNYLEWQKIAAELGTNRSAFQCLQMYQQYNKDLKRKEWTKEEDHMLTQLVEEM
RVGNHIPYRKI--VYYMEGRDSMQLIYRWTKSLNPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGFWTPEEDAKLLQAVAKYGER
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNAKEEEKLIELIEKYGAGHWAK
IASELPHRTGSQCLS-KWKALIRKKKRPRKRQKSRKKC-----SSCSSSSSSSS------
----------SSEDAQLEWHNDLEKEKDAEG--------ALDEHQYTVPSIDLWMPTRHS
HSEP-CKDPGWCYSRPSTISP----CLSKASGPSKDGSQAIPSVAVAKRR--DFSQ----
------------------------------DK----------------DILTPTMDME-C
TTL--------------S----------------------------ADIGLEKPQEELEE
KERLKKTHLFTSSLASKI--DNGMAI--EKVVQVWHKTFLN----RQR--QQKVGIQRKR
LDRKLLMAVTPWVGDIVIPCWSS-RKAVTVQTRAEAI--MTKLQT---IHLTSTPVF---
----------TLFIQLLQIDTDGCMKVIGERKTKQSELLWAITGNPQ-RPQQAS-SSLQK
--TSGCLMMKGVSKETQKKSISKMK--DLPE---------------------STQPGPTV
LPTSFGPISKPKTVSELLREKRLR-----ESRA-RKALESTVILA-----PQVLITPPVI
LQQSLQPLIPS-------TLAM----TQPLGSGSA-------------GKPVAVAS--SP
VATFQTPSPIIASTKSPEKSQSSS-------------------MRSEGHSVPSESPVPAI
AANPVPGISQISTSSGPANLLSSQATTASK--------------------KQELPNAPVL
APSQVSMQQ--PKPISLVPALSVPTCGPQVISSNMFPITWVVTTQGLVPMSMSTFVGLPG
PGK-PAGTPVLPITA----REMSA---P--------------------------------
------------------------------------------------------------
-----LSQPETQPQTK------SP---TNQ--PR--------------------------
---TEPDG------------------------------------CDCAPTP--EPGKSIL
DLNLLSLENEASIR-EWLKGKQGVCLP---PLQSTLPYLPPFLCNLKTLSGLLLQKKSLE
QKAVTIVAQGSIQDKN--------DVSREDVQSARHLVQQQLKENPAYLLLKARFLAAFA
LPAFLATLPPPRVPTTLSQILDRNSGSEEEKEEEEYSQSKTRPKDRDCGEKEQLVSTAGD
TQSTPETV------------------ASIQVSPHPDPHAMSS------ALDAADFNVLKT
RNAIHARKRRRV--

------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------------EVEKE
EDSSDDDTVNSLPEDPETCLQMNHVYQEVIQEKIEEVELLIAQNKEQQKEIMCELDGTKT
AKAADGRNLPANIFLGHFMK---PYFKDKTTGIGPPSNEDAKEKAAQGIKSFEQLLSTKW
KSREKVLLQKSVVSDRLQRLLQPKLLKLSYWNQKLEKVKTEMEKQILEKQIKEVEQEIEA
INQLPESDLLGDRFDEHDWEKISNIHFDGQRSSEELRKFWQNYEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KKEWTEEETER
LKKIAAEHGYLDWQTIAQELGTNRTAFQCLQKYQAYNKDLKRKEWTRDEDLMLLELVQEM
RVGSHIPYKKILVAYYMEGRDSAQLIYRWTKSVDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGPWTPEEDAMLLAAVKKYGER
DWYKIRTEVPGRSDAQ---CRD-RYLKA

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHCDVK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWSLEEEEQLIDLVQKHGLGHWSK
IASELPHRTGSQCLS-KWKLMIGSKKFPQGW-HKLTFSYRYIMSCQKRSRP----AKRRH
---VEEESTSCSDSSSEDIELDLTDSSEEEI---T------KKEECAFPSIDLWIPTQSS
TQET-NKGRYQTSSLFSSMSANARTSNSEVPRVLCDGGKDGVAD-KSAELNTILRGIARP
HSTDIT-VTNP----------------------------VEKASRCGKQVLRVTLEDV-R
RVL---RNNTCYQMK-------------------------------------------L-
AQQSKMVKPFSTGLTKMSGAA--TSA--DQKLQGLQL--KK----SYR--QKRERLKRIN
LDRKLLMAVTPWVGNVLLPCTLQTGKMAFHQTKAYAI--QEKMKS---ISLSSTPLF---
----------TLFIQLFQIDTNGCMKVIREGRLKQSELKANAAGPQQIITVKLF-S----
----------SSSSQPYTQRNSQRGVPRSAVRRPVALKARETSAAGLQSS--APVLAMQV
ALPAQAQRQKPKTVSELLKEKRLR-----ESQA-KAAMQRTVFIA-----PQVLVPGPLI
IQQPPQQIV--PSAQAGSTPGAVGCANSDVRFAPAQLPAFTSVAGSTSTTTVVENH--SS
SVPKTGESS-GSSEGPK--V----QS----------------------------------
------------------VVLQNQAFVPRQIAVVPVGVESGSN-------KLSLPTPLPC
---DPNGNGPQQRPGNFLPALVAPQAGSRLVPSSVLPFTWVVTPQALLPTSVQAVMGVPQ
-G-------LPAAA-VKSQSQASVMSDGS--ALGVAPVPAGANTPHPSSTETKAPSSQLA
EGVPLGKATLEN-HSVSLL--PVTSANPACSTPAVSSA-----DAS---------SKTSD
CSAAQHSPPADAPALH--AALLPQ---TQL--PA--STAG---SEGAVLQPRDPAPPNNV
PK-NSEGFAAQ----VLK-------PRPIASKPPATQ---------------PAGGKTQL
DFSLISLEDEEVVK-EWLSGEQGVQVP---LLQTRLPYFPPFLCNLKTLSRLLLQKAALE
KQAACLLPSDGSRDEG----------AGVDLRAITELVHQKLGDDPAFLLLKARFLAAFT
LPAVLATLSPPKVVTTLSGSRKQDDESDEEEW-----QSENEVSE--E--E---------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDVDAEREKISKEIKELE
RILDPGSSGINDDVSESSLDS---DSEAES-LPDDDAD--ATGPLL---S-EDERWGDAS
ND-EDDAKERALPEDPETCLQLNMVYQEVVREKLAEVSLLLAQNREQQEEVSWALAGSGG
RRVKDGRSPPARLYVGHFMK---PYFKDKVTGAGPPANEDTREKAAQGVKAFEELLVTKW
KSWEKALLRKAVVSDRLQRLLQPKLLKLEYLQQKQSRATSDAERQALEKQVREAEKEVQD
ISQLPEEALLGHRLDSHDWEKIANVNFEGGRSAEETRKFWQNHEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSAQEVDR
LKAIAAKHGHLRWQEIAEELGTRRSAFQCLQKYQQHNAALKRREWTQEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQAM
GVGSHIPYRRI--AYYMEGRDSTQLIYRWTKSLDPALK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGLWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLRLSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWSAQEEERLLELIGKHGVGHWAK
IASELPHRTDSQCLS-KWKIMARKQQSRGRR--RRRPLRRVCWSSSSEDSEDSGDSGGSS
S---------SSSSSEDVEPEGAPEARADGP--------APPSAQHPVPDMDLWVPTRQS
ARVP-WGVGPGAWPGHRSASP----RPPEGSDVAPG-------------E--EAGRAQAP
SETPSA-SLRG--GGCPRS----------ADARPS--GSEGLADEGPRRPLTVPLETV-L
RVL---RTNTAALCR-------------------------------------------AL
KEKLRRPRLLGSPLGPSPSDGS-VAR--PRVQPRW---------------RRRHALQRRL
LERQLLMAVSPWVGDVTLPCAP--WRPAVLHRRADGI--GKQLQG---ARLASTPVF---
----------TLLIQLFRIDTAGCMEVVRERRAQPPALPSGGRV---------P-SSARN
--SPGHLFQNGSARGAAKKSASHSGGGGPQS-----------------------------
APAPSGPRPKPKTVSELLREKRLR-----EARA-RKAAQGPAVLP-----PQGLLSSPAI
LQPLPP-----------QQLPV----SGAVLSGP--------------GGPAVASP--GA
PGPWASAK-----EGP---PSLHA-------------------LALAPASM-AAGVTPAA
PRAPALGPSQVPASCHLSSLGQSQAPATSR--------------------KQGLPEAPPF
LPAAPSPIQLPVQPRSLTPALAAHTGASHVVASTPLPVTWVLTAQGLLPV--PAVVGLPR
PAG-PPDPEGLSGTPPPSLTETRAGRGPKQP--------PA-------------------
--------------HVSVGPDPPAKT-------PPTAQSPAEGDGDVAHGPGGPSCPGEA
QVAGEASVPRTLSPAK------PL---ADH--PEAEPC-----------GSSQLPLPGGL
SPGGAPTRH-------------------------------QGLERPPPPWP--GPEKGAP
DLRLLSQESEAAVR-GWLTGQRGVCVP---PLASRLPYQPPTLCSLRALSGLLLHKKALE
HRAASLVPSGAAG----------------AQQAPLGQVRERLQSSPAYLLLKARFLAAFA
LPALLATLPPHGVPTTLSAAAGVDSESDDD-----S-LDELELA--DN--GGPLGGWPSG
RQAGPAAP------------------TPTQGAPG--EGSAAPG------LDSDDLDILRT
RHAWHARKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNQEQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSSSSSSSGSGGSGR
GSS------SSSEEEE--PEPEQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AEAWLGGHAASL----SPSKGSSASQGGSKEASATAAAPGE--ETSAVQAP
ATAHSP-VPRA--AQASHS----------ADTHPV--GAEKQALEGGR--LTVPLETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-SDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPAEAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSQVSVSCPGGGLGQSQAPTASR--------------------KQSLPEASPF
LPAVPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTVPPAPPTHAASRSPAEVDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPP-----------LPRRLPPLGGV
IPASEPGGTLGSPSGTQEPKGPLDLEKPSLPQAGP--------------------EKGVL
DLGLLSQEAEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLRDNPAYLLLRARFLATFT
LPALLATLAPHGIRTTLSAASIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIRELE
RILDPSSSGTHMEISESSFES---DSEADS-PPSEDLD--AADALI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLADANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KSWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSEPERQALEKQAREAEREIQD
INQLSEEALLGNRLDSHDWEKISNMNFEGSRSAEEIQKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEELER
LQAIAAAHGHLEWQRIAEELGTSRSAFQCLQKFQQHNKTLKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPALK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGCWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RQRARHRVRWSSSSSSSSGGS--SRGG
GS------G---SSGSDDEEPEQAQAGDGGR--------ALLSPQYVVPDVDLWVPARQS
T------GGAGDWLGCPAASP----NPLKGSNASQGDSKEASATPTAPGE--GSSPAQAP
ARAHSP-VPRA--AQASHL----------ADTPPA--GAEKQAPECGRRLLTVPVETV-L
RVL---GTDTAARSC-------------------------------------------TQ
KEQLRQPPLPSSSPGVSP-GDG-VAR--SHVRWLRHRATQS----GQR--RWRQALHRRL
LDRRLLLAVTPWVGDVVLPCTQAPQRPAAVQTRADGL--REQLQQ---AHLTSTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPRAAARDPPLHLPQAS-SNAQS
--TPGCPFPNVPAQEASK-SASHKGSRSRAS-------------SRA-----ERTLPQVS
PLAPTGPRPKPKTVSELLQEKRLQ-----EARA-REAARGPVLLP-----SQLLV-SPVV
LQPPLP--HAPHCRP-APGPAV----SNAPLSGP--------------GTPAAARP--GT
SGFQQEVGT-SATDKRL--STLQA-------------------LPLAPAFTGAEGTAPAA
SRAPSLGPGQVSVSCPGSSLGHSQAPAASR--------------------KQGLPEAPPF
LPAAPSPAPPPVQPLSLT-----HVGGPGVVASVPLPVTWVLTAQGLLPVPVPAVVGLPR
PVG-TPGPTGLLATLLPPLTEAQAAQDPRA------------------------------
------------VANMNVEPEPSCRTDPPAPPTQAPSQSPAEVDDSVAL------VPGEA
QVAREIPAP----MAS------TQ---TDL--PEAEPP-----------CPRRLPDLGGA
IPASEPAGTPGSPSGTQEPRGPLGLE------------------RPPLPQP--GPEKGAL
DLGLLSQEGETATQ-EWLGGQRGVRVP---PLVSRLPYQPPALCSLRALAGLLLCKKALE
HKAASLVGL-PTGVKT--------EQPAGVLQAARGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSAASMAGSES--EEED--L--SELELA--DG--AGQLGHVVAT
--------------------------RPVQGAPDSGECSASPCQGASDDLDVDDLDVLRT
RHARHTRKRRWLV-

------------------------------------------------------------
------MGVGVFEGEW---DPGMVLVS---NILGCVLEAGEVMDIDAEREKITQEIKELE
RILDPSSSGMHMETSESSLES---DSEADS-PPSEDLD--AADALI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLADANLLLAQNREQQEELMRDLAGSKG
TKVRDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSEPERQVLEKQAREAEKEIQD
INQLPEEALLGDRLDSHDWEKISNMNFEGSRSAEEIQKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEELER
LQAIAAAHDHLEWQRIAEELGTSRSAFQCLQKFQQHNKTLKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPALK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGCWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGK-QGLRRR--RRRARHRVRWSSSSSSSSSGGSSRVG-
--S---------SSSSDEEEPEQAQAGEGGL--------APLSPQYVVPDMDLWVPARQS
T------RGAGDWLGCPTASP----SPLKGSSG----SKEASTTPTAPGE--ERSPAQAP
ARAHSP-VPRT--AQASHL----------ADTQPA--GAEKQAPECGRRLPTVPMETV-L
RVL---RANTPVQSC-------------------------------------------TQ
KEQLGQPPLRSSSPGVSP-GDS-MAR--SHVRWLRHRAAQS----GQR--RWRQALNRRL
LDRRLLLAVTPWVGDVVLPCTQALRRPAAVQTRADDL--REQLQQ---AHLTSTPVF---
----------TLFTQLFQIDTAGCLEVVQERKALPPSLPRAGAQDPSLHLPQAS-SSAQN
--TPGRPFPNLLVQEASN-SASNKGSRRRVS-------------GRA-----ERTLPQVS
PLAPTGSRPKRKTVSELLQEKRLQ-----EARA-REAARGPVLLP-----SQLLVSSPVV
LQPPLP--HAPHCRP-APGPAI----SNAPLSGP--------------GTPAAARP--GT
SGFQQEVGT-SATDKRL--STLQA-------------------LPLAPAFTGAEGTAP--
----SLGPGQVSVSCPGSGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPTPPPIQPLSLT-----HVGGPGVVASVPLPVTWVLTAQGLLPVPVPAVVGLPR
PVG-TPGPAGLLATLLPPLTEAQAAQDPRA------------------------------
------------VASMKVEPEPSCRTDPPAPPMQAPPQSPAEVGGSVAL------VPGEA
QVAREVTAP----MTS------TQ---TDL--PEAEPP-----------WPRRLPDLGGA
IPASEPAGTPGSPSGTQEPRGPLGLE------------------RPPLPQP--GPEKGAL
DLGLLSQEGEMATQ-EWLGGRRGVHVP---PLVSRLPYQPPALCSLRALAGLLLHKKALE
HKAASLVHL-PAGVKM--------QQPTGVLQASRGLVQGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGIRTTLSAASMAGSES--EEEE--L--SELELA--DG--TGQLGHRVAT
--------------------------QPVQGAPDSGECSASPCQGASDDLDVDNLDVLRT
RHARHTRKRRWLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKIAKEIEELE
RILDPSSSSISVEVSESGLAL---DSEADS-LPEEDSD--AAGSLA---S-EEERWGEAS
NG-EDDPK-KTLPEDPETCLQLNMVYQEVIQERLAEVSLLLAQNREQQEEIMCDLAGSKG
PKVKDGKSLPPNLYIGHFMK---PYFKDRVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRRSVVSDRLQRLLQPKLLKLEYLHQKRSRVTSEAERQVLEKQSREAEKEVRD
IRELPEETLLGNRLDGHDWEKISNINFEGGRSAEEIRKFWQNCEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSGPEVEQ
LKAIAAKHGHLQWQKIAKELGTGRSAFQCLQKYQQHNRALKRREWTPEEDHLLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGLWAPEEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFGLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWSAKEEEKLMELIEKYGVGHWAK
IASELPHRTGSQCLS-KWKIMVRVRLVQKSV--RR-PT------------------GK--
-----------------------------GQ----------------EP-----------
------------------------------------------------------------
------------------------------------------------------------
-------------QMPFF---------------------------------------LTQ
KKKLRQPGLLGPSVGAGPSDRA-VAG--PCVRQLWHRTIGN----RQR--WRGHSLQRRL
LERQLLMAVSPWVGDIVLPCTP--RRPAAAHTRGDGL--LSHVCH---AR------V---
----------PRVPQLFQIDTAGCMEVVRERKAQPPALLQTGTRDPVPGLLPVR-S----
---RGHSFQNVPTREAAKQSASLKGSRGLQP-------------CHA------ESGPQAP
PPAPRGPRPKPKTVSELLREKRLR-----EARA-RKAAPGAVVLP-----PQLLLSSPLV
LQPRLP--VAPHGPS-ASGLAV----TASVLSRP--------------SAPAATEP--CP
SGSR----A-SAEDGGP--STLPV-------------------LAGAL---ASTEAAPAA
SMVPVLGPSQVPVNCHRGGPGQSQAPAATQ--------------------KQGLPEAPPF
LPAVPSPSQLPVQPISV----GTHERGPQVVAGTPLPVTWVLTAQGLLPV--PTVVGLPG
PAG-TSDSKGLSVALSSSLPGTQIGQGPGLPGPNHPWQPPT-------------------
--------------SRDTDSDPPSKTDPPGLPMPHQSQGSMEVDRDGAH-----GPAGEA
QVAGDTAVSGAPSQAT------LL---ADH--PEAKSP-----------RPSQPPLRGGT
GPGSGPGGTAGSTLRPER------------------LGEPLGLERPPPPRP--GPERGAL
DLDLVSQEGEAVVR-EWLRGRRGVSVP---PLGGGLPYQPPALCSLRALSALLLQKAALE
RRAASLVPGG-----------------AGALHASLGQVRRWLRDSPAYLLLKARFLAAFT
LPALLATLSPDGVPTTLSVATRADPESED--DL--G-LEESELT--DG-------CST--
--------------------------SGPRGAPDPGESSASSCLDS-----SDNLDVLRT
RHSWHARKRRRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIQELE
RILYPGSSSVHLEVSESSLSS---DSDADF-LPDEDLETAA-GAPI---V-EEERWSEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGAKC
SKVKDGKSLPSYMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKMLKLEYLHEKQSRVSSDLERQTLEKQIKEAEKEIQD
INQLPEEALLGSRLDHHDWEKISNINFEGGRSAEEIQKFWQSSEHPSINKQD

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WNTEEVER
LKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPNLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WTPEEDAKLLRAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKIMARRKQRLQRR-RGRRPHHSSQWSSSSSSDS-----NGSE
GY------GGGGSSSSEDSDVEPEDSLEHGR--------ALVPQQYRVPDIDLWVPTRPV
TSQS-QREGA----GC-SSTHRAVS-CTLDAT--QSHHKEGPTTVSTPQI----SQVQM-
--------P------------------------------------CKPTFLHS--PDTHI
TSK---EDPASKSHT-------------------------------------------LL
KEGPRQPPLPNSHSESDPGDS----V--PHLRRLWHGTFQY----KLR--RKRQALHRRL
LKHRLLLAVIPWVGDINLSCTQAPRRPAVVQTQADSI--RTQLEC---ARLTSTPVF---
----------TLLIQLLQIDTAGCMEVVRERKAKPPALLQPGTQNPQPHLLQAF-SSAKN
--STGCLLPSMP-GQQTTKRDSHKGRTRLG-------------TCGTEAT---S--FQVP
VAAPGGPRPKPKTVSELLREKRLR-----ESRA-KKATQALTAVN-----GQLLISSPVI
LQPPLLPAP--QGSP-VAGPT----TSSVELSVPV--------------APVMVSS--SP
SGSWQVAAM-SATDKQP--PIR--Q-TI------PLNPSHEG-TQI-ATPAA----F---
-RSLALAPRQVPPACPLSTLGQSQASVASQ---------------------PGLPKVLPL
LPAVPSPTQLPVQPLTL--------------AKASLPINWVLTTQKLLSVPVQA-VGLTQ
PVM-TPDT----------------------------------------------------
----IGPPA-------KQL--P--------------------------------------
-------SSATTPAR--------V---GQL--LASTNT----------------------
-----------------------------APKGPQ--------GQEIPAA--SGPEKKAL
DLSLLSQESEAATL-AWLKGCQGACVP---PLGSRMPYQPPSLCNLRALSSLLLHKKDLE
QKASSLVDSQAAGSQP--------EPKSGALQTSLGLVQRQFQDNPAYLLLKTRFLAIFS
LPALLATLPPNSVPTTLSAAMAVGSESDSEDL-----LGDQELKD--R--ARQLDCLGCR
VQASPAASSL--S-RPLPIL--------TGRAPGPGEDSAPSHLDASD-----DLDVLRT
RHARHSRKRRLR--

------------------------------------------------------------
------------------------------------------MDIDAKREKITQEIEELE
RILEPGSTGIHEEFSESSLDS---DSEADS-LPAEDLE--AAGALI---S-EEERWGEAS
ND-EDDPKDRALPEDPETCLQLNMVYQEVLQERLAEVGLLLAQNREQQEEITWDLAGSKG
PKVKESKNLPPNMYIGHFMR---PYFKDKVTGVGPPANEDAREKATQGIKGFEELLVTKW
KSWEKALLRKSVVSARLQRLLQPKLLKLEYLQQKQSRVSSEPERQVLEKQIREAEKEVQD
ISQLPEEALLGNRLDSHDWEKISNVNFEGGRRAEDIRKFWQNSEHPSINKQA

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSEEEVAR
LQAIAATHGHLEWQKVAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRKI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGLWAPEEDAKLLQAVAKYGEQ
YWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWDLKEEEQLTELIRKYGAGHWAK
IASELPHRSGSQCLS-KWRIMAGKKQSLRRR--RRRPRHSVQWSSSSSSSSSRDSSG---
-DS---SRGGSGSSSS--DEVEQEPAWEGST--------ALLSPQYMVPDIDLWIPARQS
ASQP-RRGGTKAWLGCPAASP----SPPEGASATQEGGKETSTPNLAPRE--IASQAQAP
SGTHSA-MPKG--IQDSCL----------ADIPPA--SSKEP---DGKHSLKVPLETV-L
RVL---RTNTAMQRR-------------------------------------------TL
KEKLKKLPLHSSSLGAIPS-DN-VAQ--AHVRRLWHGTFQN----GQQ--HWRRALQRRL
LDRRLLLAVTPWVGDITLPCTQAPQRPTAMQTRADGL--REQLQH---THLASTPVF---
----------TLFIQLFQIDAAGCMEVVRERKAQLPGLLQAGARDSALHLLQAP-SGVQS
--TPGCLSPDVPAREATK-STRQRGSRGLEA-------------SRT------HTPPQAL
PPAPHGPRPKPKTVSELLREKRLR-----EACA-RKAAQGPTLLP-----PQLLVSSPVI
LP------PAPHGSS-APRPAI----SDTVCSRS--------------GASAAGGS--ST
AGSWQERGT-SAQDERP--STQQA-------------------LALVPASMGTQGTAPDA
SRTPALSPSQGPVSCPLRGPGQSQAPATAR--------------------KQGLPEALPF
LPATPSPTPLPARPLSLT-----HGSGPHVAASVPLPVTWVLTAQGLLPV--PTMVGLPR
PAG-TPEPTALLLTPVLPPADTRAAKGPQQ------------------------------
-----------ILASTDAGPNPFSRTDPSASPTHSPSQNPAEVDCEVAF------VPGEA
QGAGERSGP----RTC------HS---AEH--PAA-VL-----------CSSQPPAGGAA
GPGSEPGGMTGAPL-AQEPRGPLGLE------------------GPPSAWP--GSEKGAL
ALGLLSLESEAATR-EWLRGRQGVCVP---PLGNRLPYQPPSLCSLRALSGLLLHKKTLE
CKAASLRADGVAGGEA--------EPQAGSLQASLALARWQLRDSPAYLLLKARFLAAFT
LPALLATLPPHGVPTTLSAATRVGSESEGEDED--L-AGEPGLA--DG--DAQLGCTVAT
--------------------------SPVQRALDPGEGSAPFCWGASEDLDADDLDVLRT
RRTRHIRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPGSSGSHVEISESSLES---DSEADS-LPSEDLD--PADPPI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSVRWSSTSSSGSSSGSSGGSS
SSS---SS------SSEEDEPEQAQAGEGDR--------ALLSPQYMVPDMDLWVPARQS
TSQP-WRGGAGAWLGGPAASL----SPPKGSSASQGGSKEASTTAAAPGE--ETSPVQVP
ARAHGP-VPRS--AQASHS----------ADTRPA--GAEKQALEGGRRLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFHIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAS-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
LLASTGPRPKPKTVSELLQEKRLQ-----EARA-REATRGPVVLPS-----QLLVSSSVI
LQPPLP--HTPHGRP-APGPTV----LNVPLSGP--------------GAPAAAKP--GT
SGSWQEAGT-SAKDKRL--STMQA-------------------LPLAPVFSEAEGTAPAA
SQAPALGPGQISVSCPESGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPTPLPVQPLSLT-----HIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPR
PAG-TPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPA-------------------
--------------NMNREPEPSCRTDTPAPPTHALSQSPAEADGSVAF------VPGEA
QVAREIPEP----RTS------SH---ADP--PEAEPP-----------WSGRLPAFGGV
IPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKG-ALDLEKPPLPQP--GPEKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVVGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPQGVRTTLSVPSRVGSES--EDED--L-LSELELA--DR--DGQPGCTTAT
--------------------------CPIQGAPDSGKCSASSCLDTSND--PDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIQELE
RILYPGSSSVHLEVSESSLSS---DSEADL-LPDEDLEA-T-GTPI---V-EEERWSEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSQLLAQNQEQQEEILYDLSGTKC
SKVKDGKSLPSYMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKMLKLEYLHEKQTRVSSDLERQALEKQIKEAEKEIQD
INQLPEEALLGNRLDNHDWEKISNINFEGGRSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHSHLEWHLVAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WTPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKIMARKQQHLQRR-RGRRPNRSSQWSSSSSSDS-----EGYG
SSN----SSSSSSSSSEDSELELEEPLENGR--------ALVPQQYRVPDIDLWVPTRLI
TSQS-QREGA----GC-YPAHRAAS-CTLDTT--QSHHKEGPTTVSTPQI----SQHVV-
--------K------------------------------------VPLE-------KMLK
LIR---ARPATQNHT-------------------------------------------LV
KERLRQPSLPNSHSESDPGDN--VAV--PHLRRLWHGTFQN----KLR--RKRQALHRRL
LKHRLLLAVIPWVGDINLSCTQAPRRPAIVQTQADSI--RTQLER---AHLTSTPVF---
----------TLLIQLLQIDAVGCMEVVRERKAQPPAVLQPSTQNPQPHLLQAF-SSAKN
--STGCLLPSMP-GQQTTKRDSHKGRPRLG-------------TCGTEAT---S--FQVP
VAAPGGLRPKPKTVSELLREKRLR-----ESRA-KKATQALTAIN-----SQLLISSPVI
LQPPLLPAL--QGSP-VAGPA----TSSVELSVPV--------------APVMVSS--SP
SGSWQVTGM-SATDKQP--PIQ--Q-TI------PLNASHKG-TQI-AAPAA----F---
-RSLALAPRQVPTGCPLSTLGQSQASVTSQ--------------------KQGLSKVLPL
LPASPSPTQLPVQPLSLPPVLGSQASGQPQAAKASLPINWVLTTQKLLSVPVPA-VSLPQ
SVM-TPDT----------------------------------------------------
----IGPPA-------KQL--P--------------------------------------
-------SPATTPAC--------L---GQL--PASTDT----------------------
-----------------------------EPKGPQ--------GQEIPTI--SGPEKKAL
DLSLLSQESETATL-TWLKGCQGACVP---PLGSRMPYQPPSLCSLRALSSLLLHKKDLE
QKASSLVTSQAAGSQS--------EPKAEALQTSLGLVQRQLQDNPAYLLLKTRFLALFS
LPALLATLPPNSVPTTLSPAVAVGSESDSEDL-----LGDLELKD--R--ARQLDCLACR
IQASPAATDP------------------EQRAPGPGED-----LDASD-----DLDVLRT
RHARHSRKRRLL--

------------------------------------------------------------
------------------------------------------MDIDAEREKITKEIKELE
RILDPSSSSINVEVSESSLDS---DSDADS-LPDEDSD--TAGPLI---S-EEDRAGEAS
ND-EDDPKEKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEVMWDLAGSKG
PKVKDGKSLPPNLYIGHFMK---PYFKDRVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KSWEKTLLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRVTSEAERQVLETQSREAESEVQA
INQLPEEALLGSRLDSHDWEKISNVNFEGGRSAEEIRKFWQNSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSGQEVDQ
LKAIAAKHGHLEWQKIAEELGTSRSAFQCLQKYQQHNKALKRKEWTEQEDRMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGFWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNSKEEEKLMELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKVMVRKKQSRGRR--RRRPPRSVRWSSSSEDSSSGDRSRRGS
SSS---SSSSSSSESSEDSEPGPEEAQEGGQ--------ALPSAQHAVPDMDLWVPARQS
TSEL-WGRGAGGWPGCSAASP----SPPKGSSAAQGVTGKLAPQ-----R--RRARRRPP
TRAHST-SLTG-----------------------------------------SEYTRS-V
DTH---PESSEGPADELH---------------------------------------TCV
PEKLRQPHLLCSPLGECPSGSG-VSG--PRVRQLWHGSARS----RQR--RRGPTLQRRL
LERQLLMAVSSWVGDVVLPCTS--RRPTVVQTQADRI--RKQLQE---AHLASTPAF---
----------TLFLQLFQIDTAGCMEVVRERKAQPPTLLQAGTRDPLTRPLQVR-REGEP
---QVPPLPSFSVREVAKKSTIHREREGLQA-------------PR------NESTPQAP
PPAPCGPRPKPKTVSELLREKRLR-----EARA-RTAAKGPVVVP-----PPLLGSSPVT
LQLRLP--LVPQGPP-ASGPAV----SNAALCGR--------------GPPATASA--ST
PGSWASAKD-E---RPY---TLQA-------------------LAL--A--VRSPAAPVA
SRVPVLGPDQVPGGCPLSSFGQSQAPATSR--------------------KQGLPEAPPF
LPAAPSPTQLPIQPSMPA----------L--GTSPLPVTWVITAQGLLPVPMPAVVGLPQ
PRG-TPDP-KGLL--PASQPGPEKG-----------------------------------
----------------ALGLER----------L---------------------------
-----------------------P---A--------------------------------
---SQPGPE-K---------GALGLE------------------RLPASQP--GPEKGAL
GLSLLSQESEAAVR-EWLRGQRGVCVP---ALGRRLAYQPPTLCSLRTLSGLLLQKKALE
RRAASLVPGGVAG----------------ALHASRGLVHRRLQDSPAYLLLKARFLAAFT
LPALLATLPPDGVPTTLSTTTRADSES--ENDS--L--GELELA--DG--GRQLGSSVSS
PQAEPAATASV----------ESPLLSASQRAPSPMERAASAVLPS-RAH-LDDLDVLRT
RHARHARK------

------------------------------------------------------------
------------------------------------------LDLDAEREKIRREIEQLE
RSLQPGGADIPLPLSDSSLSS---VSEIFF-LCQGQR-P-----PC---S-VSLQTPQ-A
VGTQQVQLRKCLPQDPETCLQMNHVYQEVIKEKIEEVELLIAQNKKQQKEIISELHGPKP
AKAGDGRNLPPNVFLGHFMK---PYFKDKITGIGPPSNEDAKEKAAQGIKSFEQLHSTKW
KTAEKTLLQKSVASDRLQRLLQPKLLKLSYWNQKLEKVKTETEKQILEKQIKDLEQEIEE
INQLPEGDLIGNRFDEHDWDKISNIHFDGQRSSEELRKFWQNWEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 454)

KKEWTEEEIEK
LKQIAAKHNYLDWQTIAQELGTNRTAFQCLQKY

ENSGT00390000001038_0_Linker_2_3 (454, 462)

QIYNKDLK

PF00249 // ENSGT00390000001038_0_Domain_3 (462, 511)

RKEWTKDEDQMLLELVQEM
RVGSHIPYKKI--AYYMEGRDSAQLIYRWT

ENSGT00390000001038_0_Linker_3_4 (511, 519)

KSVDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 563)

KGAWTPEEDAMLMAAVEKYGEK
DWYKIRREVPGRSDAR---CRE

ENSGT00390000001038_0_Linker_4_5 (563, 575)

RRYLKVLHRNLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGKWSLEEEDQLIELVEKHGLGHWSK
IASDLVHRTGSQCLS-KWKHMIGSKDGIYA-----------K---KKRCGA----SKRCH
---AEESSSPSESSSEEDMELDLADSSEEEGTSTK------SNEECAVPSIDLWIPTGAD
TQEA-TRERAGAGSSCSDIPR-----------AGCDR--DRAAD-KSSELSTLLRGIGKS
CSTDVL-VKNPAEVMAKVSWDRSLDQKLESFPVC----FHIQASQCGKQVLQVSLEEV-R
TIL---RRNTGFQRK-------------------------------------------L-
ARQSK-----------PPGEG--AAA--GQDAQGLQELPER----AGR--RPRECWRKLS
LNRRLLMAVTPWVGNVLLPCTVQAGSMAFYQTKAAAV--HELVKS---LSLSSTPLF---
----------ALLVRLFQIDTKGCMKIIKERKLRQLELLKANARSP------QQ-R----
----------LPKIRTLLQRNSQGGIPRNSVRRS-ALRARSSAPGALES----CARAVQG
APPGQGQRQKPKTVSELLREKRLR-----QSQA-KKALQRTVLVA-----SPVLVSGPLI
IQHPPQAFD--NPAPTTANH---------SLCTSS------------ASALVPENC--SS
AVPEAGDSP-GCSNGMD--L----QSTE---------------------------KA---
-PDLGGCNGQVPASSSASAVLQNQASVPHQMAVVPLGLVSGTN-------TLSLSTPVTC
---ELKSNGPQQTPVSLLPALVPPQAASPVIPNSILPFQWVVIPQTLLPSTVQTAVGAPQ
-G-------MPAAA-GKSQCQTNVTSNGNVSALGGTLVPAGAKPPHPSSAETKGPSSQ-L
AGAPLGKAADQS-TIPL----PLPSVCPGSTTSSVSVVTPACSDGS---------SMAPD
SSA----APAASSAPC--AIVLPQ---TQP--PA--SPQG---SDSQPV-----------
-----PSLTSL----ELR-------NRPIASKPPSA------DVPPQPST--SSAEKNLL
DFSLISMEDEGLVK-EWLTGKQGVQVP---SLQTRLPYLPPFICSIKTLSKLLVQKAALE
EQAASLLPSEASGDGG----------TGDVFHAVGELVQQKLGDNPAYLLLKARFLAAFT
LPAVLATLPPPKVTTTLSASRKQHEDSDDEEW-----QSKKNVSE--E--E---------
------------------------------------------------------------
--------------

------------------------------------------------------------
-----------------------------------PCRQAEAMDIDAEREKITQEIQELE
RILYPGSSSVHLEVSDSSLSS---DSEADF-LSDEDLETA--EAPT---L-EEGRWSEAS
NEEEEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSQLLAQNQEQQEEILFDLAGTKC
PKAKDGKSLPSYMYIGHFLK---PYFKDKITGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLREKQSRVSSELEKQALEKQIKEAEKEIQD
INQLPEEVLLGNRLDNHDWEKISNINFEGGRNAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHGHLEWHLIAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

RGSWAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

IRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 620)

KGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKVLARKKQRLQKR-RLRRPRHSRQWSSSSSSDSS---SEGYG
GGSSSSSSSSSSSSSSEDSDMELEESLENGR--------ALVPQPYSVPDIDLWVPTRPI
TSQS-QREGS----GCCCPAHRAVS-CTLDAT--QSQHKEDSTTVSTPEM----SQVPC-
-ETHRT-FP------------------------------------RRARFLPL--PDIHL
ANM---EDPASKSHT-------------------------------------------PV
KQGPKQPPLPNSCSESDPGDS--VAG--PRLRRLWHGTFQN----KWR--RKRQALHRRL
LKHRLLLAVIPWVGDINLSCTQAPRRPAVVQTQADSI--RMQLER---ARLTSTPVF---
----------TLLIQLLQIDTAGCMEVVRERKTQ------PDTQNPQPHL-QAS-SNAKN
--STGCSLPSMP-GQQTAKRDSNKGRPQLG-------------SCETEDT---S--FQV-
-TAPHGFRPKPKTVSELLREKRLR-----ESRA-RKATQALAAIN-----SQLLISSPVI
LQPPPPPAP--QGSP-VAGPA----TSSMELSVPV--------------APVMVSS--NS
PGSWQVAGI-SATDKQP--PTL--Q-TI------PLNPSHKG-SQI-VAPAA----F---
-RSLALAPRQVPTGCPLSTLGQSQASATSQ--------------------KQGLPKVLPL
LPAAPSPSQLPGQPLSLPPVLGPQASGQPLAAKASLPVNWVLTTQKLLSVPEPAVVGLPQ
SVT-TPET----------------------------------------------------
----IGSPA-------KQP--P--------------------------------------
-------SPATTPAC--------L---GQL--PASADT----------------------
-----------------------------EPKGPQ--------AQEVPPT--SGPKKKAL
DLSLLSQESGAATL-PWLKGCRGAHVP---PLGSRIPYQPPSLCSLRTLSSLLFHKKDLE
QKASSLVASQAAGSQS--------EPKAGALQTSLELVQKQFRDNPAYLLLKTRFLAVFS
LPALLATLPPNGVPTTLSPAMAVGSESDSED------LGDLELKD--R--ARQLDCLACS
TQASPAATDP------------------GQRAPGPGEDSAPSHLDASD-----DLDVLRT
RHARHSRKR-----

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSTGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EEDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNELEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEE--VPEPEQAEAEEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRRG-AGAWLGGPAASL----SPPKGSSASQGGSKEASATAAAPGE--ETSAAQAP
ARAHSP-VLRA--AQASHS----------ADTHPV--GAEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQLPLPTSSPGVSS-GDS-VAQ--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRKLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQR---ARLASTPVF---
----------TLFTQLLQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQVP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHSRP-ALGPTV----SNVPLSGH--------------GTPAAAKP--GT
SGSWQEAGT-SAKDDRL--STIQA-------------------LPLAPAFTGTEGTAPAA
SRAPGLDPSQVSVSCPGSGLGQSQAPTASQ--------------------RQSLPEVSPF
LPAAPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPV--PAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTDPPAPPTHAASQSPAEVDDSVAV------VPGEA
QVAREIPAP----RTS------SQ---TDP--SEAEPA-----------WPRRLPPLSGV
IPASEPGGTLGSPSGTQEPKGPLDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVH---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLMAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLATFT
LPALLATLAPHGIRTTLSAASIAGSESEDEDL-----LSELELA--DR--DRQPGCTAAT
--------------------------CHIQGPPDSGRCSASSCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------------------------
---------------------------------------------------EEESWG--E
SDEDDDSKDQALPKDPETCLQLNMVYQEVLQEKIAEIDLLLAQNKEQQEEVMWDLAGSKT
PKTKDGKSLPSNVFVGHFMK---PYFKDKVTGIGPPANEDTREKATQGIKSFEELIVTKW
KTWEKTLLRKSVMSDHLQRLLQPKLLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXFEGSRSADEIRKFWQNCEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQAWVEEETKR
LKEIAAKYNYLEWQKIAAELGTNRSAFQCLQIYQQYNKDLKRKEWTKEEDHMLTQLVEEM
RVGSHIPYRKI--VYYMEGRDSMQLIYRWTKSLNPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 568)

KGFWTPEEDAKLLQAVAKYGER
DWFKIREEVPGRSDAQ---CRDRXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXX
XXXXXXXXXXXXXXX-XXXXXXXEKK--------RRQKYR----------------KK--
-YRSSSSSSSSSSSGWNRSG--IMT-------WRRRDMLGTRGMQYVVPSIDMWIPTRQS
HAAL-WKDPGEGYS---RPSTL-SPCLSKASD-LQSGSK-AIPK-----V-------AV-
--------------------------------------------------------ALRR
DPD---WDKDTLDHS-------------------------------------------TV
KERLKKTHLFTSSLXXXXXXX--XXX--XXXXXXXXKTFLN----RQR--QQKINIQRKR
LDRKLLMAVTPWVGDITIRCWRSQ-KAVTVQTRAEAI--MTKLQT---IHMTSTPVF---
----------TLFIQLFQIDTDGCMKVIGERKTKQSELLLAIRGKSQQPQQXXX------
------------------------------------------------------XXXXXX
XLPSLGPKPKPKTVSELLREKRLR-----ESRA-NKALENTVILA-----PQVLVTPPVI
LQQPLQTSP--FLSFPGPTAN-SGSSL--------------------GNEVIVEENINKT
------EG---TSAPQV--LSL----T-----------------TVFESP------VPRT
TTNQALGVNQISTSSGPASLLSSQVTTTSG--------------------NQELPKASPF
LAPAQ-ISMQQPKPISLVPTLSVPTCGPQVISSNILPITWVVTAQGLVPVSVSTLVGLPG
PGK-PAGTPVLPILGGVAKSQATLK--PAFIN---SQQSPGAPEPSPSPKDHLF-PVKLF
KGMPGTAGP----SLPTHLPTTASS-------HTVSQ--SEKSNLT---------FFGGG
KTAGEMSAPSPQPDSL--RPRAPQTNQGQSLMTYCASTPE---AEPSWSEYR--------
----RPGFHTE----ILETKD-NLILRNPFPSQGHKK---GWAQDNQPKA--LEPGKSVL
DLSLLSLENEASVR-EWLKGGKGVCLP---QLQSTLPYLPPFLCNLKTLSGLLLQKKSLE
QTAATMVAQGRVQDKN---------ECPDRMQAARHLVQQQLKENPAYLLLKARFLAAFA
LPAFLATLSPPRVSTTLSGPWTNNVSEEE-------------------------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIQELE
RILYPGSSSTHLEVSESSLSS---DSEADF-LPDEDLGTA--AVPV---L-GEERWSEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSQLLAQNQEQQEEILFDLAGTKC
PKVKDGKSLPSYMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKPFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHEKQSRVSSELDRQALEKQIKEAEKEIQD
INQLPEETLLGNRLDNHDWEKISNINFEGGRSAEEIRKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WNAEEVER
LKAIAAAHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

RGFWTPEEDAKLLQAVAKYGAH
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

IRRLHFNLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKIMTRKKQHLQRR-RGRRPHHSSQWSSSSSSDS-----EGYG
GSSGSSS---SSSSEDSGSEMELEESLENGR--------ALVPPQHRVPDIDLWVPTRQT
TSQS-QREGA----GR-YLEHRAVS-YTLDAT--QSHHKEDSTTVSTPEV----SQVQMP
CEPHST-VP------------------------------------RGSS---T--SKHGR
PSQ---TRPTTQSHT-------------------------------------------LV
KKRPMQPPLPNSCSGSDPGDG--VAG--PHLRQLWRGTLEH----KLR--RKRQALHRRL
LKHRLLLAVIPWVGDINLSCTQAPRRPAAVQTQADGI--RMQLES---ARLTSTPVF---
----------TLLIQLLQIDTAGCMEVVRERKTQSLALLQPGTQNPQPHLLQVS-SSAKN
--STGCLLPSIP-GQQTAKRDSHKGRPQLG-------------SCGASAA---S--SQVP
VAAPRGLRPKPKTVSELLREKRLR-----ESCA-KKATQALTAIN-----SQLLISSPVI
LQPPLLPAP--QGSP-VAGPA----TSSVELAVPV--------------TPVMVSS--SP
SGSWQVAGI-SATDKQP--PTL--Q-TV------PLNPSHKG-THI-AAPAA----F---
-RSLAPAPMQVPTSCPPSTLGQSQASATSQ--------------------KQGP----PL
LPAAPSPTQLPIL----PPVLGP----QPLAAKASLPVNWVLTTQKLLSVPVPAVVGLPQ
SVM-APET----------------------------------------------------
----VGPPT-------KQL--P--------------------------------------
-------SPAMTPAC--------Q---GQL--PVSADT----------------------
-----------------------------EPKGPQ--------GHETPPT--SGHEKKTL
NLSLLSQESEAATL-AWLKGCQGACVP---PLGSRMPYQPPSLCSLRALSSLLLHKKDLE
QKASSLVASQAAGSQT--------EPKPGALQTSLELVQRQFRDNPAYLLLKTRFLAIFS
LPALLATLPPNSVPTTLSAAMAVGSESDSED------LGDLELKD--R--ASQLDCPTCR
VQADPTATAA----IQVRML--------GQRAPGSCEDSSPSHLSTSD-----DLDVLRT
RHACHSRTQRLL--

------------------------------------------------------------
------------------------------------------MDVDAERERIVEEIRELE
RILGAGSSGDHGQVSESSLDS---DSGADS-PPEEDMD--TTEPLV---S-EEEKWGEAS
DG-EDEPRDKALPEDPETCLQLNMVYQEVVREKLAEVSLLLAQNREQQEEVTWDLAGSKG
PKVKDGKSSASHVYIGHFMK---PYFRDRVTGMGPPANEDTREKAAQGVKTFEELLVTKW
KGWEKALLRKAVVSGRLQRLLQPKLLKLEYLQQKQSRASCEQERQMLERQTRDAEQEVQT
LSQLPEETLLGSRLDSHDWEKISNVNFEGRRSAEEVRKFWQNSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQDWSGEEVER
LQAIAATHGHLEWQEVAEELGTGRSAFQCLQQFQRHNPALRRRAWTEEEDRVLAQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

RGLWAPEEDAKLLRAGAKYGEQ
DWFKIRQEVSGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWSAQEEEQLLRLIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMTGKRQGPR----RCRPRRSVRWSSSSSEGSEDGSGGSSG
GSS--------SSSSSDGEDLEAELVPEETP--------ESGGVQYVVPDVDLWAPARQR
ASQP--PGGAGCWQRHPATFS----SLLKGSGTAQGGNRGTSAAAWAHGQ--ETGQAQAP
SGTHST-VLGG--AQEAC-----------------PASSEEPASEDGQCLLKVPRESV-L
RVL---RTGMAARRRM--------------------------------------------
-LKPRRPPRPGPPQGAGPG--S-AAG--PHLQRLWHGTVQN----GQR--R-RRPLHRRL
LECRLLLAVSSWVGDVILPCTRA-QSPSTQLTSADSI--REQLQG---ARLASTPVF---
----------AIFIQLFQIHTAGCLEVVQERKAPPPPLLPASTRDPPRLLQXXXXXXXXX
-XXXXXXXXXXXXXXXXX-XXXXXXXXXXXX-------------XXX------XXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXX-----XXXX-XXXXXXXXXXX--XX-XXXXXXXXXX
XXXXXX--XXXXXXX-XXXXXX----XXXXXXXX--------------XXXXXXXX--XX
XXXXXXXXX-XXXXXXX--XXXXX-------------------XXXXXX--XXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------------------XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXX-XXXXXXXXXXXXXXXXXXXXXXXX---------XXXX-------XXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X--XXXXXXXXXXXXXX------XX--X
XXXXXXXXX----XXX------XX---XXX--XXXXXX------------XXXXXXXXX-
--XXXXXXXXX---------XXXXXX--------------XXXXXXXXXXX--XXXXXXX
XXXXXXXXXXXXXX-XXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X-XXXXXXXXXXX--XXQPGCVVP-
------------------------SPSPVEGALGPCKGPVPSCLDA-----AADLDVLRT
RHALHARKRRRLSG

------------------------------------------------------------
------------------------------------------MDVDAEREKITKEIKELE
RILDPSTSNIHMEVSESSLDS---DSDADS-LPSEDLE--AVDPPI---L-EEERWGEAS
ND-EEDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWDLAGSRG
PRVKDGKSLPPNMYIGHFMK---PYFKDRVTGVGPPANEETREKAAQGIKAFEELLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLRQKQSRVSSESEQQALEKQVREAEKEIQD
INQLPEEALLGNRMDNHDWEKISNIHFEGGRSAEEIRKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSVEEVEQ
LRAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLKKGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYLRRLHFSLKKGRWNEKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKVMAGKKKSLRRR--RRRPCRRVRWSSDSSSS-----CSTGG
GSS---SS--SSSSSSEDPETELEEPQKGLR--------GPLSPKYTVPDMNLWVPARQN
TSQL-QRGEAGGCSGHPAAFT----GPSKESDATQGCSREASSTALAP-Q--ELNQREAP
TGIHSP-IPRG--VQDPHL----------ADHHPA--SLEEPASEGGQHLLKVPLVTV-Q
KVL---RTSMAVQNR---------------------------------------------
-------------------------------TLLRHGTFQN----GQQ--HRRHNLHRRL
LERRLLLAVTPWVGDIALPCAQVPPRPAAVHTRANTI--RMQLEP---AQLASTPVF---
----------TLLIQLLQIDTAGCLDVVRERKTQPPTSLQSGTQGLPPHLLQAP-SCAQS
--TPGCPFPNVPTRNATK-SASHRGSTGQES-------------CQA-----NSTSPQAP
VAAPRGSRPKPKTVSELLREKRLR-----EARA-RRATQGPAL-P-----PQLLVS-PVT
LGPPVLPAPQPQGSP-ATGS-V----SSTDCFGP--------------GALMAASA--CP
SGCWQETGV-SAKDEGL--PTLQA-------------------LPLSP------------
----APSPGQVPVGCPLSILGQSQAPTTSR--------------------KQGLPEVLPF
FPAAPSPTQLPMQPLNLTPALGTHRSGTPLAASIPLPVTWVLTAQGLLPMPVPAVVGLPG
PAG-LPAKFPPPC------CE----------APACPSQPQA-------------------
--------------SVDTEPAPSSRTDTSAPPTCPPSQSPLEVGGNVPG------ALGEA
QVVKEATVP----RTS------SQ---TNC--PEAEPS-----------RPSQLSASVGT
GPTNGSGGTLE---------PGGPLG------------------LEKPQLS--GSEKGVL
DLSLLSLESEAATR-QWLRGQQGVHVP---PLGNRLPYQPPTLSSLRALSNLLLHKKALE
HKASSLVASGAAG----------------TLQASLELVRRQLQDNPAYLLLKARFLAAFT
LPALLATLAPHGIRTTLSVATRASSES--EDED--L-LSELDLE--DR--DNRLGCAPSR
TQTRPATTVPI----------QGALVSNE--------GA----VPSHSDT-SDDLDVLRT
RHGRHARKQKPLL-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIKELE
RILDPSSSSIHVEVSESSLDS---DSETDL-LPGEGLD--AADPPI---L-EEERWGEAS
ND-EDDPKDRTLPEDPETCLQLNMVYQEVIREKLAEVSLLLAQNREQQEEITRDLAGPKG
PKVRGGKGLPPNAYIGHFMK---PYFKDKVTGVGPPANEETREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRVSSEPERQALDKQIREAEKEVRD
INQLPEEALLGNRLDNHDWEKISNVNFEGGRGAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVER
LKVIAASHGHLEWQKVAEELGTRRSAFQCLQTFQRHNGTLRRREWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

RGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKVMIGKRQGLQRR--RRKPRRRVRWSSSSSSSGGDT-SSGGG
GSS---SSSSSSSSSSEESEAELEQAQEGGK--------ELLSPQYVVPDMDLWVPARQS
TGQG-WKGGAEGRPGRPAASL----GPPTGPSAAQGGREEASTTMSATRE--ELSPAQAP
SSIHGT-APRG--VQDSRS----------RDVPPA--SSEELALKDGSRLLKVPLETV-L
RVL---RTNTATRSR-------------------------------------------TL
KEKLKQPPLPSSPLGAS-SGDS-VAQ--SHVRRLWHGTFQN----GRR--RWRHALHQRL
LDRRLLLAVTPWVGDVILPCTLAPRRPAAAQTRADGL--GKQLQH---ARLASTPVF---
----------TLFIQLFQIDTAGCMEVVRERRVQPPGLLQAGTQDSLPRPVQAP-SRAPS
--TPGCLLPNGTTQKAAKN----------AS-------------RRA-----ECAPPPVP
PPAPCGPRPKPKTVSELLREKRLR-----EARA-RKAAQGPTVLA-----PQLLLSSPVI
LQPALA--PAPHGPQ-ASGPAV----SNTAASGP--------------RGPAAASL--GT
SASWQEAGT-SAKDEGS--STLQT-------------------LP-----------LAAA
SGPPTLGPGQVTGSCHLNSLGQSQVPATSR--------------------KQGLPEALPF
LPAAPSPAQPLIQPLSLT-----HRGGPHVAANVPLPVTWVLTAQGLLPVSVPAVVGFPR
PAG-TPDSTGLPVTLLPPLAETRAAQGP--------GQPQT-------------------
--------------SMHVGPDPSPRTGPSTAPAPPPSQSPAEVDGD--V-----------
-----DCVA----RTS------PQ---ADH--LDAEPL-----------QPSRLPACGGA
GPGSDPGGTPG---------PLSGTR------------------EPRGPQP--GHEKGSL
ALGLLSQESEAATQ-EWLQGQGGVCVP---PLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVASREAGDQA--------ESWAGTLQAALGLVRGQLRDNPAYLLLKARFLAAFT
FPALLASLSPCGVPTTLSVATGTGSES--EDEG--L--EEPELT--DR--HGPPGATAAR
--------------------------SPDQGAPGPGEGSAPSCLDASPDL-DPDLDVLRT
RRARHARKRRRLL-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGSHVEISESSLES---DSEADS-PPSEDLD--PADPPI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDSKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGKEAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSVRWSSSSSSGSGSGSSGGGS
SSS---SSSSSSEEDEPEPEPEQAQAGEGDR--------ALLSPQYMVPDMDLWVPARQS
TSQP-WRGGAGAWLGGPAASL----SPPKGSSASQGGSKEASTTAAAPGE--ETCPAQVP
ARAHGP-VPRA--AQASHS----------ADTRLA--GAEKQALEGGRHLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAS-SSAQS
--TPGHLFPNVLAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
PLAPAGPRPKPKTVSELLQEKRLQ-----EARA-REATRGPVVLPSQLLPSQLLVSSPVI
LQPPLP--HTPHGRP-APGPTV----LNIPLSGP--------------GAPTAAKP--GT
SGSWQEAGT-SAKDKRL--STMQA-------------------LPLAPAFTEAKGTAPAA
SQAPALGPGQISLSCPESGLGQSQAPAASR--------------------KQGLPEAPPF
LPTAPSPTPLPVQPLSLT-----HIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPR
PAG-TPGPAGLLATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NMNREPEPSCRTDTPAPPTHALSQSPAEVDGSVAF------VPREA
QVAREIPEP----RTS------SH---ADP--PEAEPP-----------WSGRLPAFGGV
IPASEPGGTPGSPSGTQEPRGPLGLQ------------------KPPLTQP--GPEKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVVGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSVPSRVGSES--EDED--L-LSELELA--DR--DGQPGCTTAT
--------------------------CPIQGAPDSGKCSASSCLDASSD--PDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAERERISREIEQLE
RILDPSCASISMDVSESSLDS---DSDADS-LPDEDSDLDAAGPLL---S-EEERWGEAS
ND-EGDPKEKALPEDPETCLQLNMVYQEVVREKLAEVSLLLAQNREQQEEVMGDLAGVRG
LRVKDGRNPPPNLYLGHFMK---PYFRDKVTGVGPPANEDTREKAAQGIKAFKELLVTKW
KTWEKVLLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRATSELEKQVLEKQAREAEKEVQD
INQLPEEALLGDRLDSHDWDKISNVNFEGGRSTEEIRKFWQNYEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSEQEVTQ
LKAVAAKHGHLDWQSIAEELGTRRTAFQCLQKYQQHNPALKRREWTEEEDRMLTRLVQAM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGLWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 618)

KGRWNSKEVKKLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMVRQRQRARRR---ARPS------S---------------
GSS--SDSSWEGSEPEEAPKDVPEEAPAGGP--------EPPPAQYAVPDMDLWVPARQS
TEEL-GGAVAGGCXGTR--------------GPGRGGRRGYARWRRRPGCGAEASPLRGV
APMPGP-FPES--CPGQHW----------LPRSRPPP-SPQLARFFAGWLFRAPLGTG-P
WVLGTGL---------------------------------------------ATGAS-CS
TPSCRDHPHPRHPPVSLPY-PS-WP---GHPPALWHLGGGS----LGL--RCAHQPARRT
LSPFLGEGSGRWHAGSGWLCSRA------RVPSADGI--RRQLQG---AQLASTPVF---
----------ALLIQLFQIDTPGCVEVVRERKTWPPALLQAGAWDPPPLQE--P-SSARS
--TPGTARLPLPLSGWFM-SRPPAGSRGA---------------LWAQASG-TASPAGAC
LSPHQQDQAAPKTVSELLREKRLR-----EARA-RRAVQGPAFLS-----ARVLVSAPVV
LQPLAP-----------PGTSV----SRVVLSGP--------------GGPPVTSS--SV
SGSWAPAKA-----ERG--LTLHT-------------------FALGPA-----------
---TSRAPGQVPASCPLSALGQSPAPATSR--------------------KQGLPEAPPL
LPAAPSP----VQPVSLTPALGTP-----TVASTPLPVTWVLTAQGLLPVPLQAVVSLPT
PTG-APDPTQLSVTLPPSPAETPASRTPPP------------------------------
------------------------------------------------------------
------------------------------------------------------------
--RRGPRGAA----------------------GGPGAPQPLDLEEPLLPWL--GLENGPL
DLSLLSQESEAATQ-EWLRGQQGGPVPALGPLGSQLAYQPPTLCSLRALSSLLLRKKDLE
HGAAVLAPDGPAG----------------ALQASLGRVRERLRNSPAYLLLRARFLAAFT
LPALLATLSPRGVPTTLSASAGPDPETDSDELW--W-LTDRSPQ--VK--EGSAGSQS--
------------------------PTWPQEGAPDPSQGPARSCLDS-----PDNPDMLQT
RRLRHVRKRRRLQ-

------------------------------------------------------------
------------------------------------------MDIDAEREKISKEIKELE
RILDPSSSSIPVDISESSLDS---DSDAES-LPAEDLD--IAGPPV---L-VEERWGGGS
ND-EEDPKEKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
PRVKDSKGLLPHMYIGHFMK---PYFKDKVTGMGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKAVVSDRLQRLLQPKLLKLEYLRQKQSWVSSEPERQALEEQARCAEQEIQD
INQLPEEALLGNRMDSHDWEKISKVNFEGSRSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSMEEVER
LTAVATAHGHLQWQLVAKELGTGRSAFQCLQKFQQHNKALKRREWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 520)

LTQLVQQM
RVGSHVPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLKK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHASLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWTAQEEEQLLGLIEKHGVGHWAK
IASELPNRSGSQCLS-KWKIMAGKKQRVQRRRRQRRPRPRVRWSSSSSSSGDSDSGGSGS
S-------SSSSSSSSKDSEVELEEPPQAGS--------MPPSPQYTVPDMDLWVPVRHS
ATQR----------------------------------PEASRTALAPGE--ERRQVQAS
SEVLGT-----------HS----------AGTQHT--NLEEPAHK---------------
------------------------------------------------------------
-ERLRQPPRPSLPPGPGP-GDR-EAG--AHLRQLWRRTFQN----RHQ--RRRRILHRRL
LERRLLLAVAPWVGDVNLPCTLAPQRPAVTKTRADGV--RTQLER---VHLASTPVF---
----------TLCMQLLQIDTAGCMEVVRERKAQLP---PPGPQHPLPRPLQVP-PGAPA
--PPGCRPQQASAQDVVRNTHSRS--TEPKS-------------CWVQTTS-----AQAL
TPPPQGPRPRPKTVSQLLREKRLH-----KAPT-RKATLGPVSLT-----PQL-LISPVV
LQQPLT--SACQGPP-VVGPAF----TSTGLPRP--------------VTPTATVT--SA
SGSQQEVGT-SGKDKDQ--CL-----------------------PM----------SQVP
QLAPTLGPGQAPAGCPPSSLGQSQAPTTTR--------------------RQGLPEVPTC
LPAAPSPAQPHIQPLSLTPAL---------ATSIPLPITWVLTAQGLLPVQVPAVLGLPT
PGE-VLQPPKTPALAPPTPSG----------PPTSPCQPPA-------------------
--------------NMGTEPAPSSRTAHS------PPQSSTEA------------TGGEA
QVARPASAP----RMS------SQ---ANS--PHTGSP-----------QPDHLPGPSGP
SSGGDPGGTAV-------PSGPLG------------------LE--RPLLP--GLEKRAL
DLGLLCLESEVVTQEQWLRGQRGVCVP---PLETRLPYQPPALCSLRALSSLLLHRAALE
HKAASLAVDRAVG--------------PVAWRTSLELVRRQLQDNPAYLLLKARFLALFT
LPALLATLPPDGVPTTLSAVLSTGLESTDE--D--L--SELESGDGDG--NEQLGCTAPR
IQARPMPMSP-----------------MQ-GTPDSGEG-AVSCLDA-----SDDLDVLRT
RHGRHNRKRRWQL-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGSHVEISESSLES---DSEADS-PPSEDLD--PADPPI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQ
DWS----------DAQ---CRD-RYLRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSVRWSSSSSSSSGSGSSGGGS
SS------SSS---EEDEPEPEQAQAGEGDR--------ALLSPQYMVPDMDLWVPARQS
TSQP-WRGGAGAWLGGPAASL----SPPKGSSASQGGSKEASTTAAAPGE--ETSPVQVP
ARAHGP-VPRA--AQASHS----------ADTRLA--GAEKQALEGGRRLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTHADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAS-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQ-----EARA-REATRGPVVLPS-----QLLVSSPVI
LQPPLP--HTPHGRP-APGPTV----LNVPLSGP--------------GAPAAAKP--GT
SGSWQEAGT-SAKDKRL--STMQA-------------------LPLAPAFTEAEGTAPAA
SQAPALGPGQISVSCPESGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPTPLPIQPLSLT-----HIGGPHVATSIPLPVTWVLTAQGLLPVPVPAVVSLPR
PAG-TPGPAGLLATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NMNREPEPSCRTDTPAPPTHVLSQSPAEVAGSVAF------VPGEA
QVAREIPEP----RMS------SH---ADP--PEAEPP-----------WSGRLPAFGGV
IPASEPRGTPGSPSGTQEPRGPLGLEKPPLPQPGPEKGGALDLEKPPLPQP--GPEKGAL
DLGLLSQEGEVATQ-QWLGGQRGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVVGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVHTTLSVPSRVGSES--EDED----LSELELA--DR--DGQPGCATAT
--------------------------FPIQGAPDSGKCCASSCLDASND--PDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDSDSERAKITQEIRELE
RILEPGSSGVSLDLSESSLDS---ASDDDS-LLVEDSD--APGPPI---V-EKDRWGEAS
NE-EEDSRDRNLSEDSETCLQLNMVYQEVVQEKMAEVNLLLAQNRAQQXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXLEYLQQKQ

PF00249 // ENSGT00390000001038_0_Domain_0 (336, 404)

SRAQSEPEKQLLEKQVQDAERDIAD
IHQLPEEALLGSRLDSHDWEKISNVNFEGGRSAEEIRKFWQNCEHPSINQQAWSSEEVER
LQVLSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXX--XXXXXXXXSTQLIYRWTKSLDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGCWTPEEDAKLLQAVAKHGEH
DWFKIREEVPGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_6 (569, 575)

LRFNLR

PF00249 // ENSGT00390000001038_0_Domain_6 (575, 594)

KGRWNSKEEEKLLELIEKHGVXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXX-
X-X---------XXXX-XXXXXXXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXX
XXXX-XXXXXXXX---------------XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXX
XXXXXX-XXXX------XX----------XXXXXX----------XXXXXXXXXXXXX-X
XXX---X--XXXXXX---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXPLSPTSLRSSCPG-Q--TAG--PPVRCLWPGSTLN----GQQRRRQRHTLQRRL
LTRRLLMAVGPWVDRVILPHTQIPQRPA-VSTQADGV--QKQLRS---VQLTSTPVF---
----------TLLIQ---------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDIDAERVRISQEIRELE
RILDPGSSSINVDISESSLNS---DSDADS-LPDEDSD--AAGPLP---L-EGERWGEAS
ND-EDDPREKALPEDPETCLQLNMVYQEVIREKLAEVSLLLAQNREQQEEVMWELVGCKG
SRVKDSKTLPSSLYMGHFMK---PXXXXXXXXXGPPANEDTRERAAQGIKAFEELLVTKW
KTWEKALLRKSVASGRLQRLLQPKLLKLEYLQQKQSSSTSEAERQILEKQAREAEKEVRD
INQLPEESLLGNRLDDHDWEKISNVNFEGSRSAQEIRSFWRNLEHPAIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQEWSARELGQ
LQAIAAAHGHLHWQKIADELGTCRSAFQCLQKYQQHSPALKRREWTEEEDRVLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGLWAPEEDAKLLRAVAKYGEQ
GWFKIREEVPGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFGLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWNSKEEEKLIELIEKYGVGHWAR
IASELPHRTGSQCLS-KWKMLVRKQQRRRR---GRRPPRKARWSSSSGDSSTASSGD---
--------------SGDSEPEAALGALTGGQ--------ALLPTQHVVPDVDLWVPARQS
AREL-WGGGPGSWPGPCGACP----RPPEGSDPAQGGRWEACTTASAPAE--PAGQARAA
SGTQST-SLRG--IQCPCS----------TDARPS--SSTGPAHQGGRP---GPLEMA-L
QVLPD----VATW----------------------------------------------C
QKELRQPHLRSAAPGPTPGGGGGSGRARPCVRPLWHRTGQ-------R--RQGHALQRRL
LEHQLLTAVSPWVGKVILT---QPRRPAVAHSRADGI--RRQLQG---AHLASTPVF---
----------TLFIQLFQIDTAGCMEVVRERKARPPALLRAGARDSPLLQXXXX-----X
XXXXXCLLQSVPARGAAKKSTCPMGSGGAA--------------CHA------ESTPQAP
PPAPSGPRAXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXX-----XXXXXXXXXX
XXXXXX--XXXXX-X-XXXXXX----XXXXXXXX--------------XXXXXXXX--XX
XXXXXXXXX-XXXXXXX--XXXXX-------------------XXXXX----XXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXSR--------------------KQGVPEPLT-
--AAPSP-VLPVQPLSLTPALGTH-----TAASTPLHVTWVLTAQGLLSVPVQAMVGLPR
PAGT--LSLGLSVTLLPSPAATQAGQGPRLSGQGRPWQPPT-------------------
--------------NTDTESDPASGTELLTLAAHPTSQSPAEVDMAHGP--GG-CAPGE-
-----TSVPRTSSQAR------PW---LT-------------------------------
----AEAEPPGTTSGPGEPRRPSG------------------LEGPPPPRR--RPEKRAL
DLRLLSQEGEAAVR-EWLRGQRGVRVP---PLGSRLSYQPPTLCSLRTLSGLLLRKKALE
HRAASLAQRA-----------------AGALQASLGRVREQLRDSPAYMLLRVRFLAAFA
LPALLATLSPRGVPTTLSVAMRSSPESDSDDSS--P--GQPELV------AGQPGCAAAA
--------------------------MPAQGSPHPGQASAPSCPDS-----PDELDVLQT
RHARHARKRRRLE-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIKELE
RILDPSSSGTHMEISESSFES---DSEADS-PPSEDPD--AADALI---S-DEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLADANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSEPERQVLEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNMNFEGSRSAEEIQKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREELER
LQVIAAAHGHLEWQRIAEELGTNRSAFQCLQKFQQHNKTLKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPALK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGCWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHRVRWSSSSSSS-SGDSSRVG-
--G---SSS---SSSSDAEEPEQAQAGEGGR--------ALLSPQYVVPDMDLWVPARQS
T------RGAGGWLGCPAASP----SPLKGSTASQGDSKEASATPTAPGE--ERSPAQAP
ARAHSP-VPRA--AQASHL----------ADTQPA--GVEKQAPECGRRLLTVPVETV-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQPPLPSSPPGVSP-GDS-MAR--SHVRWLRHRAAQS----RQR--RWRQALHRRL
LDRRLLLAVTPWVGDVVLPCTQAPQRPATVQTRADGV--REQLQQ---AHLTSTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPRAGARDPPLHLPQAS-SSAQS
--TPGRPFPNMPAQEASK-SASHKGSQRRAS-------------SRA-----ECTLPQVS
PLAPTGPRPKRKTVSELLQEKRLQ-----EARA-REAARGPVVLP-----SQLLVSSPVV
LQPPLP--HVPHCRP-APGPAV----SNAPLSGP--------------GTPAAARP--GT
SGFQQEVGT-SATDKRL--STLQA-------------------LPLAPAFTGAEGTAP--
----SLSPGQVSVSCPGSGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPAPPPVQPLSLT-----HVGGPGVVASVPLPVTWVLTAQGLLPVPVPAVVGLPR
PVG-TPGPTGLLATLLPPLTETQVAQDPRA------------------------------
------------VASMNVEPEPSCRTDPPAPPTQAPSQSPAEVDGSVAL------VPGEA
QVAREIPAP----MTS------TQ---TDP--PEAEPL-----------WPRRLPDLGGA
IPASEPAGTPGSPSGTQEPRGPLGLE------------------RPPLPQP--GPEKGAL
DLGLLSEEGETATQ-EWLGGRRGVHVP---PLVSRLPYQPPALCSLRALAGLLLHKKALE
HKAASLVRL-PAGVQT--------QQPTGVLQASRGLVQGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGIRTTLSAASMVGSES--EEED--L--SELELA--EG--ARQ-------
---------------------------LVQGAPDSGQCSASPCQGASDDPDVDDLDVLRT
RHARHTRKRRWLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIRELE
RILYPGSSSVHLEVSESSLSS---DSEADS-LPDEDLEIT--GAPI---L-EEERWSEGS
NG-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILLDLSGTKC
PKVKDGKSLPSYMYIGHFLK---PYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLDYLHEKQSRVSSELEKQALEKQVKEAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGARSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSAEEVER
LKAVAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKSLKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGL

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILVRKKQHQQRR-RGQRPRHSSQWSSSGSS----SSS-SSE
DYGGG------SSSSSEESDVELEESLKNSQ--------ALTPQQYRVPGIDLWVPTRLV
TSQS-QREGT----GC-YPQHPAVSCCMQDAS--QNHHKEGSTTVSAPEK----NQLQVP
YETHST-VR------------------------------------RGDRFLHF--SDTHS
ASL---KDPACKSYT-------------------------------------------LM
KEGPRQPPVPNSRSGSDPGNS--MAG--PHLRQRWHGTFRN----KQR--RKRQALHRRL
LKHRLLLAVIPWVGDINLACTQAPRRPTTIQTQADSI--RMQLEC---ARLASTPVFTLL
IQVSPSTPVFTLLIQLLQIDTVGCMEVVRERKGQPPALLQPGIQNSQLHLPQAS-SNAKK
--STGCLLPSMP-GEQTAKRASHKGRPRLG-------------SCRTEAT---P--FPVP
GAAPRGLRPKPKTVCELLREKRLR-----ESHA-KKATQAL-GLS-----NQLLVSSPVI
LQPPLLPAP--HGSP-GVGPA----VSSVELSVPV--------------APVLVSS--SP
SGSWQVGGI-SATDKQP--PNL--Q-TT------SLNLSHKG-TQI-AAPAA----F---
-RSLALAPGQVPTGDHLSALGQS--TQK---------------------------PGLPI
LPATSSLTQLSVRP---------PASGQPLATKSSLPVSWVLTTQKLLSVQVPAVLGLPQ
SVT--PET----------------------------------------------------
----IG---------------P--------------------------------------
-------SPAKTSAL--------L---EQP--PASIDT----------------------
-----------------------------EPKGPQ--------GQEIPPT--PGPEKKAL
DLSLLSQESEAATI-TWLKGCQGVCVP---PLGSRMPYQPPSLCSLRALSSLLLHKQDLE
QKASSLVASQAAGAQPEPTTGAQPEPTTGALQASLELVQRRFQGNPAYLLLKTRFLAIFS
LPAFLATLPPNSVPTTLSPDMAVVSESDSED------LGDLELKD--R--ARQLDCMACR
VQASPAAPDP--V----------------QRAPSPGEVSAPSPLDASD-----DLDVLRT
RRARHSRKQRLL--

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSTGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-VTAGLI---
------------------------------------------------------------
-------------WLCHWVGPASTFQSGLGGGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLNETLS-QKQTAFPSQQE---NPQARRGANTLIPS
SSQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQEWSGEEVEQ
LQAIAAAHGQLEWQKIAEELGVRT--------------------WPGPQGP-------GD
LKDLPLPLSLV--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEE--EPEPEQAQAEEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGPTASL----SPPKGSSASQGGSKEASAIAAAPGE--ETSAAQAP
ARAHSP-VPRA--AQASHS----------ADSHPV--GAEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSCPGASS-GDS-VAQ--SHVQWLRHRATQS----AQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQR---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEK--------REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-APGPTV----SNVPLSGP--------------GTPAAAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGAEGTAPAA
SRAPGLDPSQVSVSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAAPSPTPLPIQPLSLT-----HVGGPCVAASVPLPVTWVLTAQGLLPVPVSAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPRAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRADPPAPPTHAASQSPAEVDDSVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPA-----------WPRRLPPLGGV
IPASEPGGTLGSPSGTQEPKGPLDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEGEAATQ-QWLGAQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLATFT
LPALLATLAPHGVRTTLSAASIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------CHIQGPPDSGRCSASSCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILYPSSPSARLEVSESSLSSDSE----DS-PPHEDVD--AASAPH---V-EEERWGQAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSLLLAQNQEQQEEILFDLAGAKC
PKVKDSKSLPSNMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KHWEKDLLRKSVVSDRLQRLLQPKLLKLEYLHQKKSRVSSEPEKQALEKQVRETEKEIED
INQLSEETLLGNRMDSHDWEKISNVNFEGRRSAEEIRKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSAEEVER
LKAIAAAHGHLEWHLVAEELGTGRSAFQCLQKFQQYNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 520)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPNLKK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWTPEEDAKLLQAVAKHGAQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNAKEEEQLIELIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILVRKKQRLQRR-RWRRPRQSTQWSSSSSDSSSGSDGSGH-
-------WSSSSSSSSEGSEAELEEPLESSR--------EPLSSQYTVPDIDLWVPARQ-
---P-WRKGAEYCSGHPIVST----CPPNGSDATQGHHKEVSPTASAPDE--MNQVQVTL
CD---P----------------------------------------QHCPKKCPGLTF-I
THLPSNQGNPACQSR-------------------------------------------TL
KERLRQPLQPNSPPGPGP-GDS-MTG--SHLRQLWHGTFQR----RQR--YRRQALHRRL
LKHRLLLAVIPWVGDITLPCTPSSWKPAAVQTQADSI--RRQLEH---AHLASTPVF---
----------TLLIQLLQIDTAGCMEVVRERKIQSQHQQAPG-LTLLSLLSQEP-SSAQS
--TTGCLFPSLAAQHTAKR-ASSRGRPQLKS-------------H-------SQSATQVP
TPAPRGLRPRPKTVSELLCEKRLR-----ESRA-RKAAQSPTTVP-----NQLLLSSAVI
LQPAVP--PAPQGSA-ATGPAM----SSAQLCGP--------------VAPIVITS--SP
SGSWQEAEF-SAKDKQI--PSLQA-------------------LPLTPTLNGVQGITSAA
YRSLVPTPSQILVSCPLSNLGQSQAPVISQ--------------------KQGLPKILPF
LPAASCPTQLPMHPLNLTPALGTQP----LAARASLPANVVLTAQRLLPVSMPAIVSHPQ
PVR-PPEPTGLPVTLPASTKTPTS-----------PVQP---------------------
------------------------------------------------------------
------------------------------------------------------------
-----------SASADGEPRGPQG--------------------KEKPPLA--GPEKGTL
DLSLLSQESEAAIQ-AWLRGRQGACVP---PLGSQLPYQPPALCSLRALSSLLRHKKDLE
RKAASLAASSAAEVQP--------ESRAGVLQASLGLVRRQLQDNPAYLLLKTRFLAVFT
LPALLATLPPDSIPTTLSSAMRESSES--EEEN--L-LGDLGLK--DR--AGQPDCVTQA
---------------------GSPATNPIQGAPDPGEGSAPSQLDA-----SDDLDVLRT
RRARHARK------

------------------------------------------------------------
------------------------------------------MDVDAERERISREIQQLE
RILDPCCSSVSMDVSESSLNS---DSDADL-LPDEDLDSDAAGPLL---S-EEERWGEAS
ND-EDDPKEKALPEDPETCLQLNMVYQEVVREKLAEVSLLLAQNREQQEEVMGDLVGVKG
PKVKDDRNPPPNLYLGHFMK---PYFRDRVTGVGPPANEDTREKAAQGIKAFTELLVTKW
KTWEKVLLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRATSELEKQILEKQAREAEKEVQD
INQLPEEALLGDRLDSHDWDKISNVNFEGGRSTEEIRKFWQNHEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSEQEVAQ
LKAVAAKHGHLDWQSIAEELGTHRSAFQCLQRYQQHNPALKRREWTEEEDRMLTRLVQAM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGLWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYLRRLHFSLKKGRWNSKEVKKLIELIEKYGVGKPGL
PCLRTVHSRGGGNISKLWRAGSLLLRGLSSSCVLWAQQHSLLWSAAGRAGAPAVEAA---
-----ANSSWEDSEPEEAPKDVPEEAPAGGP--------EPPPAQYAVPDMDLWVPARQS
TEELRWLPGAGAPTRGPSGAC----AQPRCSTPLPGGHRGCAQWRQRPGCGAEASPLHVT
APAPGP-FPES--CPGQLL----------TPWRPAPSVSPACSLSPGCRVLCVPNGSQ-L
RAEPSP---------------------------------------------HARGLSLPK
QERLRQPHPPGSAPGLSPGGGS-RDEARPRVQPQWARTAQ-------R--RQGHALQRRL
LEHKLLTAVSPWVGEVDLLCAR--PRPAMRPRRADGI--RRQLQG---AHLASTPVF---
----------ALLIQLFQIDVTGCMEVVRERKAWPPALLQAGAGDPLPLQVRTERASARL
PSSPGCLTQSVPAQGAAKQSTCPEGGRGPQA------------CCT-------ASMPRAA
APAPCRPRPKPKTVSELLREKRLR-----EARA-RRAAQGPAVLS-----ARVLVSTPMV
LQPLAP-----------PGASV----SRVVLSGP--------------GGPPVTSS--SV
SGSWAPVKN-----ERA--PTLHA-------------------FALSPA-----------
---TSRAPGQVPASCPLSALGQSQAPATSR--------------------KQGLPEAPPL
LPAAPSPVQLPVQPLSLTPALGMP-----AAASTPLPVTWVLTAQGLLPVPLQAMVSLPP
PTG-APDPTQLSVILPPSPTETRASRGPRLPEQSRPGPPAA-------------------
--------------STDLEPEPPCRTEPLSK-------SPTEVAEACGLA-ELTSHEEEA
LVSGETSAPRTPSQDT------PL---AHH--PATGPP-----------SSSPQPLHGAP
GAASGPREPQ-----------PLD----------LEEPQPLDLEEPLLPWL--GLENGPL
DLSLLSQESEVATQ-EWLRGQQGVPVP---ALGSQLAYQPPTLCSLRALSGLLLRKKDLE
HGAAVLAPGGPAG----------------ALQASLGRVRERLHDSPAYLLLRARFLAAFT
LPALLATLSPRGVPTTLSASTGPDPETDSDDFD--P--EEPELTD--S--DGQPG-----
--------------------------DPAQGAPDPSQGSAPSCPDS-----PDNLDVLQT
RRSRHVRKRRRLQ-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHMEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGNWDPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSSSSSSSGSGGSGR
GSS------SSSEEE--EPEPEQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHVASL----SPPKGSSASQGGSKEASATAAAPGE--ETSAVQAP
ATAHSP-VPRA--AQASHS----------ADTHPV--GAEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQASARDPPVHLLQAP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLS-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPAEAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAAAFTGPEGTAPAA
SGAPGLGPSQVSGSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAAPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-MPGPTGLVATLLPPLTEAQAAQGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPACGTVPPAPPTHAASRSSAEMDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPL-----------LPRRLPPLGGV
IPASEPGGTLGSPSGTQEPKGTLDLEKPPLPQPAPEKG-ALDLEKPPLPQPAPAPEKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSAASMAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIQELE
RILYPGSTSVHFEVSESSLSS---DSEADS-LPDEDLETA--GAPI---L-EEEGSSESS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLSGTKC
PKVKDGRSLPSYMYIGHFLK---PYFKDKVTGVGPPANEETREKATQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLHEKQSRVSSELERQALEKQIKEAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGARSAEEIRKFWQSSEHPSISKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKTLKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILARKKQHLQRK-RGQRPRHSSQWSSSGSS----SS--SSE
DYGSSSGSDG--SSGSENSDVELEASLEKSR--------ALTPQQYRVPDIDLWVPTRLI
TSQS-QREGT----GC-YPQHPAVSCCTQDAS--QNHHKEGSTTVSAAEK----NQLQVP
YETHST-VP------------------------------------RGDRFLHF--SDTHS
ASL---KDPACKSHT-------------------------------------------LM
KERPKQPLLPSSRSGSDPGNN--TAG--PHLRQLWHGTYQN----KQR--RKRQALHRRL
LKHRLLLAVIPWVGDINLACTQAPRRPATVQTKADSI--RMQLEC---ARLASTPVF---
----------TLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRNTQPHLLQAS-SNAKN
--NTGCL-PSMT-GEQTAKRASHKGRPRLG-------------SCRTEAT---P--FQVP
VAAPRGLRPKPKTVSELLREKRLR-----ESHA-KKATQAL-GLN-----SQLLVSSPVI
LQPPLLPVP--HGSP-VVGPA----TSSVELSVPV--------------APVMVSS--SP
SGSWPVGGI-SATDKQP--PNL--Q-TI------SLNPPHKG-TQV-AAPAA----F---
-RSLALAPGQVPTGGHLSTLGQT--STTSQ--------------------KQSLPKVLPI
LRAAPSLTQLSVQP---------PVSGQPLATKSSLPVNWVLTTQKLLSVQVPAVVGLPQ
SVM-TPET----------------------------------------------------
----IGLQA-------KQL--P--------------------------------------
-------SPAKTPAF--------L---EQP--PASTDT----------------------
-----------------------------EPKGPQ--------GQEIPPT--PGPEKAAL
DLSLLSQESEAAIV-TWLKGCQGAFVP---PLGSRMPYHPPSLCSLRALSSLLLQKQDLE
QKASSLAASQAAGAQP--------DPKAGALQASLELVQRQFRDNPAYLLLKTRFLAIFS
LPAFLATLPPNSIPTTLSPDVAVVSESDSED------LGDLELKD--R--ARQLDCMACR
VQASPAAPDP--V----------------QRAPSPGEVSAPSPLDASDG--LDDLNVLRT
RRARHSRR------

------------------------------------------------------------
---------------------------------MSRRDGPTGANLNAEREKIRREIEELE
RSLQLDVTSVDVAVSDSSLSS---GTGPHS-AASEWVLPGL-GVRC---Y-VRQWEVERE
EDSSDDDLESSLLEDPETCLQMNYVYQEVIQEKIEEVELLIAQNKEQQKEILCELDGRKT
TRTGDGRNLPSNIFLGHFMK---PYFKDKTTGIGPPSNEDAKEKAAQGIKSFEQLLSTKW
KSKEKVLLQKSVVSDRLQRLLQPKLLKLSYSNQKLENVKTEMEKQILEKQIKEVEREIEA
INQLPESDLLGGRFDEHDWEKIANVHFDGRRSSEELKKFWQNWEHPNINKNE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WTEEETER
LKDIAAKRGYLDWQTIAQELGTNRTAFQCLQKYQTYNKDLKRKEWTRDEDKM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LLELVQEM
RVGSHIPYKKI--AYYMEGRDSAQLIYRWTKSVDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 568)

KGPWTPEEDAMLLAAVEKYGER
DWYKIRTEVPGRSDAQ---CSD-RYLK

ENSGT00390000001038_0_Linker_4_5 (568, 575)

ALHRDVK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGKWSLKEEEQLIDLVQKHGLGHWSK
IASELPHRTRSQCLS-KWKIMIGSKNEIKS-----------VIYLYKRSRS----AKRQH
---AEESSSCSE-SSSEDVELDLSDTSEEEK---M------NKEECTFPSIDLWIPTQTD
VLES-CQGRHQASSPFSF---------------GSAN--AR--T-SSSKIPNARREGGE-
-----------EGANAKGVWIIPVTGLLRAFAPFANSISTSNFLWCGKQVLRVTLEDV-R
RVL---RENTCFQRK-------------------------------------------R-
VSQSKLIMSSAATLTKTSGVG--ASA--AEKHRGLWSTMGK----SRR--QERARWRKMN
LDRKLLMAVTPWVGDVLLPCTLRAGKMAFDQTKAYSI--QQKLKS---VSLSSTPLF---
----------TLFIQLFRIDTNGCMKIIRERRADAARPQQASQNLESS--SDLF-F----
----------FPFIH-LIGNAS--QPPSNTQ--R-ALP----------------ALPSPP
APLAQAHRQKPKTVSELLREKRQM-----EKQLKEKAMQTKLFVA-----PQMMLSGPLI
IQHPPQQMI--PSAQVGSKPGAGGSTDSQVQCVSASPSAFTSVAGSASTPVVLESH--SP
SVPKVGELP-GSSQETK--V----QSNK---------------------------E----
----------------------------------LNEQDSGNS-------KLSLPAPITY
---ELTHSG----PVNLLPALLAPQPGSHLTPDSMLPLTWVVTQQALLSSAVQAVVGVPQ
-G-------LQAIV--RSQSQASVTSSGSVSGLGAPPVSSGVNMPHPSHAETKTDPQL-A
AGSPAGKTAGVS-HSASVF--PVSSADPVCSVSGVSSATSAHSDSS---------SKTVD
SSAAHNALPGGAPTLH--AQLLPQ---MQL--PA--STQG---VAGNSE-----------
------GSADQ----GLK-------YRPIASKPPPEQ---TESAPPQPTT--SSAEKTLL
DYSLISLEDDELVK-EWLSGKQGVQVP---PLQTRLPYFPPFLCNLKTLSKLLLQKAALE
KQAARFLSPDGSQTEG----------EVD-LNAITKLVHEKLGDDPAFLLLKARFLAAFT
LPAVLATLPPPKVATTLSASKREYGESDEEEW-----QSEEEASE--D--ESCGDELDAP
SD-ETGGDEPGDRDADFPSKVKES------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDTDAERERITREIRELE
RILHPSSSDIGVELSESSLDS---DSDADL-LHGEDSD--APGPPV---S-EEERWGEVS
NE-EEDPKDRNLPEDPETCLQLNMVYQEVIQEKIAEVNLLLAQNHEQQEEITWDLAGSKG
PKAKGRKSLPPHVYIGHFMK---PYFKDKVTGVGPPANEDMREKAAQGVKSFEELLVTKW
KSWEKTLLRKSVMSDRLQRLLQPKLLKLEYLQQKQSRVSGEAERQLLEKQLRDTEKEIED
IHQLPEEALLGNRLDSHDWEKISNVNFEGGRSAGEIRKFWQNCEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQEWGGDEVER
LKAISAQHGHLEWQKIAEELGTQRSAFQCLQKFQQHNKDLKRKEWTEEEDCMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGCWAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYLRRLHFSLKKGRWNPKEEEK---------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGTRMGISESSFES---DSEADS-LPSEDLD--AADALI---S-EEERWGEAS
ND-EGDPKDKTLPEDPETCLQLNMVYQEVIQEKLADANLLLAQNREQQEELMRDLAGSKG
TKVKDGKSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSEPERQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNMNFEGSRSAEEIQKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSREELER
LQAIAATHGHLEWQRIAEELGTSRSAFQCLQKFQQHNKTLKRKEWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPALK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGCWAPDEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLQRR--RRKVHHRVRWSSSSSSSGGSRGGSRGG
SSS---SNS---SSSSDEEEPEQAQAGEDGR--------ALLSPQYVVPDMDLWVPARQS
T------RGAGGWLGCPTASP----CPLKGSSASQDGSKEASATPTAPGE--ERSPAQAP
ARAHSP-IPRA--AQASHL----------ADTRPA--GAEQQASECGRRLLTVPMETV-L
RVL---RANTAVPSC-------------------------------------------TQ
KEQLRQPPLLSSSPEVSP-GDI-VAR--SHVRWLRHRAAQS----GQR--RWRQALHRRL
LDRRLLLAVTPWVGDIVLPCTQAPQRPATVQTRADGL--REQLQQ---ARLTSTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPLHLPQAS-SSAHS
--TPGRPFPNVLAQEASK-STSHKGSRRQAS-------------SRA-----ECTLPQVS
PLAPTGPRPKPKTVSELLQEKRLQ-----EARA-REAAQGPVVLP-----SQLLVSSPVV
LQPPLP--HAPHCHP-APGPAI----LNAPLSGP--------------GTPAAARP--GT
SGFRQEVGT-SATDERL--STLQA-------------------LPLTPAFTGAEGTAPAA
FRASSLGPGQVSVSCPGSGLGQSQAPAASR--------------------KQGLPEAPPF
LPAAPSPTPPPIQPLSLT-----HVGGPGVVASVPLPVTWVLTAQGLLPVPVPAVVGLPR
PVG-TPGPTGLLATLLPPLTEAQTAQDPRA------------------------------
------------VANMNVEPKPSCRTDSPAPPTQAPFQSPAEVDGSVAF------VSGEA
QVAREIPAP----MTS------TQ---TDP--PEAELP-----------WPRRLPDFGGA
IPASEPAGTPGSPSGTQEPRGPLGHE------------------RPPLPQP--GPEKGVL
DLGLLSQEGETATQ-EWLGGQRGVHVP---PLVSRLPYQPPALCSLRALASLLLQKKALE
HKAASLVGL-PAGVKT--------EQPTGAMQTSRGLVRGQLQDNPAYLLLRARFLAAFT
LPALLATLAPHGIRTTLSAASRVGSES--EEED--L--SELELE--DR--ARQLGPVVAT
--------------------------QPVQGAPDSGKCSASPCQGASDDLDVDDLDVLRT
RHARHTRKRRWLV-

------------------------------------------------------------
------------------------------------------------------------
-----------------------------V-LLDEDYN-TA-GPPV---L-EEERWEEAS
ND-DDDAKEKALSEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEIMWDLAGSKG
SKVKDGKSLP-NMYVGHFMX---XXXXXXXXXXGPPANEDTREKAAQGIKAFEELLVTKX
XXXXXXXXXXXXXXXXXXXXXXXXXXXLEYLRQKQSRVTSEVEKQILEKQTGETEKEVQD
INELSEEALLGSRLDNHDWEKISNINFEGDRSAKELQKFWQNYEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KEEWSRQEVDQ
LKAIAAKHGHLEWQKIAEELGTSRSAFQCLQKYQQH

ENSGT00390000001038_0_Linker_2_3 (457, 462)

NKALK

PF00249 // ENSGT00390000001038_0_Domain_3 (462, 513)

RKEWTEEEDRILTQLVQEM
RVGDHIPYRKI--AYYMEGRDSVQLIYRWTKS

ENSGT00390000001038_0_Linker_3_4 (513, 519)

LDPNLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGYWAPEEDAKLLKAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWNSKEEEKLIELIEKYGVGHWTK
IASELPHRTGSQCLS-KWKIMLRQRQSRGRR-RQRRPLRRLQWSSSSEDSS---------
-----------SSGRSEDSESEEAP-------ETQEDVRALPSIQHTVPDMNLWVPARQS
ATGL-WRREAGGRPRCSSASPRPPKDSSAAQ---NSIRKAGITALAPT---EEMGQAQAP
FSTHSA-RPSG--VSAPHS---TDTQ---------PVTSERPAEERERQLVKVPQKAV-L
QVL---KTNTAAQRR-------------------------------------------AQ
KQKLKRPHSPCSAMEACPAGS--STA---R----LH---------GQQ--RRGHSLQRRL
LGRQLLMAVSPWIGDVVLPCSAQ--RPASTHTRADEI--RKQLQD---ARLTSTPVF---
----------TLFIQLFQIDTAGCMEVVRERKAPPPPPPQACGEPPSLPPVPSS---AQD
--TPDCLFLNVSSHQAAEKS----TLPKGG--------------GGL----------KAC
QAMPTTQPPRPKTVSELLREKRLR-----EARA-KKATQNPIVLP-----SSLLVSSPVI
LQPSHP-LA--PQVPLGTVL--SGLRA------PA-----------------------ST
SVSTS-DPS-DSVDKRP--PALKA-------------------LAIAPSPTGTGGVAPTA
SRAPAQGPNWVPVNCRLGNLGQSQAPATCR--------------------KQGLPEVPLF
LPAAPSPAQPPVQPVTLMHT-----KGPHTVASTSVPVTWVLTTQGLLPVPAMVSLTEPA
GTS-DPQG-LLVTL-PPSLNKTQADQGPQLTGLSHS-----DQPP---------------
----ANTDVELNLISRTDTPPPSF---PLA-----QSS--A--EVD---------TDTAQ
APTGKTTAPKTSPQVV------LL---ADH--PEAESSY------------SNQLPPHGV
V--------------TQE-------YHP-VPRGPL------GPERPPLPQ--PGPGKGAL
DLPSLSQESETTIR-EWLRGQRGVYVP---PLGTRLPYQPPTLCSLRALSGLLLHKRALE
HRATSLVPWDSA-----------------ALQMVLEQVRRQVQDSPAYLLLKARFLAAFT
LPALLATLPPHGVPTTLSAAAGTDSGSEDYED-----LEELDPSA--G--VTQ-------
--RGPAE-----------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSSGSHVEISESSLES---DSEADS-PASEDLD--PADPRI---S-EEERWGEVS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
AKVKDGKSLPPSTYMGHFMK---PYFKDRVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQAREAEKEIQD
I------------LDSHDWEKISNINFEGSRGAEEIQKFWQNSEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 455)

KQEWSREEEER
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGYWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 618)

KGRWDLKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMTGKKQGLRRR--RRRARHSIRWSSSSSSSSGSGSSGGGS
SSS---SSSS----EEEEPEPEQAQAGEGDR--------AVLSPQYVVPDMDLWVPARQS
TSQP-WRGGAGAWLGGPAASL----SPPKGSSASQGGSKEASTTAVAPGE--ETSPAQAP
ARAHGP-VVRA--AQASHS----------ADTRPA--GAEKQALEGGKRLLTVPVETM-L
RVL---RANTAARSC-------------------------------------------TQ
KEQLRQSPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDIVLPCTQASQRPAAVQT--QGL--REQLQQ---ARLASTPV----
---------------LFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAS-SSAQT
--TPGHLFANVLAQEASK-SASHKGSRRLAS-------------SRV-----ERTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQ-----EARA-REAVRGPVVLP-----SQLLVSSPVI
LQPPLP--HTSHGCP-APGPTV----SNVPLSGP--------------GAPAAAKP--GT
SGSWQEAGT-SAKDKRL--STMQA-------------------LPLAPAFTEAEGTAPVA
SQAPALGPGQISVSCPESGLGQSQAPAASQ--------------------KQGLPEAPPF
LPAAPSLTPLPVQPLSLT-----HVGGPRVAAGVPLSVTWVLTAQGLLPVPVPAVVSLPG
PPG-TPGPAGLLATLLPPRTEAGAAQGPRAPALSSTWQPPA-------------------
--------------NMNTEPEPSCRTDAPVPPTHAPSQSPAEVDGSVAF------VPGEA
QVAREIPEL----RTS------SQ---ADP--PEAEPP-----------WSRRLPALGGV
IPASEPGGTPGSPSGTQEPRGPLGLEKLPLPQPGP-EKGALDLEKPPLPQP--GPEKGAL
DLGLLSQEGEVATQ-QWLGGQRGVRVP---LLGSRLPYQPPALCSLRALSGLLLHKKALE
HKATSLVAGG----EA--------ERPAGALQASLGLVRGQLQDNPAYL-LRARFLAAFT
LPAFLATLAPHGVRTTLSAASRVGSES--EDED--L-LSELELA--DR--DGQPGCTTAT
--------------------------CPIQGAPDSGKCSASSCLDASKD--LDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVNAEREKIAKEIAELE
RILDPSSSGAAVGISASGLGL---DSDADS-LPDEDSE--AAGSPG---S-EEERWGEAS
NG-EDDPKDKTLPEDPETCLQLNMVYQEVIQERLAEVSLLLAQNREQQEEILCDLAGSKG
PKAKDGKSLPPSLYIGHFMK---PYFKDRVTGVGPPANEETREKAAQGIKAFEELLVTKW
KNWEKALLRRSVVSDRLQRLLQPKLLKLEYLHQKRSRVTSEAERQVLEKQSKEAEKEIQE
IRQLPEETLLGNRLDGHDWEKISNVNFEGGRSAEEIRKFWQNWEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KQEWSGQEVDQ
LKAIAAQHGHLQWQKIAKELGTNRSAFQCLQQYQQHNKALKRKEWTHEEDRLLAQLVREM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 565)

KGFWAPEEDAKLLQAVAKYGQQ
DWFKIREEVPGRSDAQ---CRD-R

ENSGT00390000001038_0_Linker_4_5 (565, 575)

YVRRLQAGLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 618)

KGRWAASEEGKLLELIGKHGVGHWAR
IASELPHRTGSQCLS-KWKIMVRKKQSRGRR--RRRPLRSVRWSSSSGDSSSGDSSGEGG
GSG---GSSSRDSEDS--EPEEAPEARAGDQ--------ELPSAQHTVPDMDLWVPARQS
TSEP-CGGGAQGWPGRRAASP----YPPRGSSEAQESSRAS-----RPTE--EAGQADTP
SGTHST-STRG--IGCPDS----------ADTDVS--NSEEPAHKSGSRLLKVPLETV-L
QVL---RTNTARRRQ--------------------------------------------T
LEKLRQPCLLSSSLETSASD-G-VAG--PPVRQLWHRTIGS----RRR--WRGHALQRRL
LERQLLMAVSPWVGDVVLPCFP--RRPATVPTRADGI--RKQLEE---ARLASTPAF---
----------TLFIQLLQIDTAGCMEVVRERKAQTPALLQTGARDPAPGLLQMS-PS-QD
--AAGRGLRNLPAQEAARQSTSQKGSRGLRP-------------CRA------ESGPQAP
LPALCGPRPKPKTVSELLREKRLR-----EARA-RKAAVGTVALP------PQLLLSPLV
LQPCLP--EAPPSPA-ASGPAA----A----------------------DPAATGL--S-
--------A-SAEDKQP--SSLPV-------------------GARGL---ASTEAAPAA
CRAPV--PSQALGSGHQDGPGQARAPAASR--------------------KPRLPEVPLV
PPAGSSPARLPVQPLGLTPALASHQGGPHVAAGASLPVTWVLTAQGLLPV--PAVVGLPG
PAG-TPDPEGLSAPLLPALPGMQAGRGPRPPGQSHPGRPPA-------------------
--------------TVDTGSDPPSRTDLATLPRFCPSQSSVEVGSDGSHARGGSSFPGEA
QAAREIAEPRIPSQTM-------T---ADR--PEARHP-----------SGSRLPLQAGT
GPGSGPGGTPGSPGPGGL-------------------TGPLGPERLRPPRP--GAERGAL
DLDLLSQESEAAVR-EWLRGQQGVCVP---PLGTRLPYQPPALYSLRALSGLLLHKKALE
RKATSLTSSGAAG----------------ALQASLGQVHRQLQDSPAYLLLKARFLATFT
LPALLATLSPHGVPTTLSVATRAEPESESD-------LEELELR--DG-------CSAGG
PQAGPAAS------------------LPPQEAPDPGQGS--SCLDS-----LDNLDVLRT
RHAWHARKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHMEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLDYLHQKQSKVSNEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRMLTQLVQEM
RIGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLKKGNWAPEEDAVSVRALGELGSG
RVTRLCSAVVPSLTGFGVGRLW-PFLQRLHLSA------CPFL

PF00249 // ENSGT00390000001038_0_Domain_5 (584, 618)

QKLLQAVAKYGEQDWFK
IREEVPGRSDAQFAQ-RWVREGLKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEEEPEPEPQQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHAASL----SPPKGSSASQGGSKEASATAVAPGE--ETSAVQAP
ATAHSP-VPRA--AQASHS----------ADTHPV--GPEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPATVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPGHLLQAP-SSAQS
--TPGHLLPNVPAQEASK-SASHKGSRRRAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEK--------REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPAAAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSRVSVSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAVPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-TPGPTGLVATLLPPLTEA---QGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPSCRTVPPAPPTHAASQSPAEVDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPP-----------LPRRLPPPGGV
IPASEPGGTLGSPSGTQEPKGTLDPEKPSLPQPGP--------------------EKGAL
DLGLLSQEAEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLRDNPAYLLLRARFLAAFT
LPALLATLAPHGIRTTLSAASIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHSRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAERERISREIEQLE
RILDPSCPSISMDVSESSLDS---DSDAAA-G--------SALGPR---S-EEERWGEAS
ND-EGDPKEKALPEDPETCLQLNMVYQEVVREKLAEVSLLLAQNREQQEEVMGDLAGVRG
LRVKDGRNPPPNLYLGHFMK---PYFRDKVTGVGPPANEDTREKAAQGIKAFKELLVTKW
KTWEKVLLRKSVVSDRLQRLLQPKLLKLEYLQQKQSRATSELEKQVLEKQAREAEKEVQD
INQLPEEALLGDRLDSHDWDKISNVNFEGGRSTEEIRKFWQNYEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSEQEVTQ
LKAVAAKHGHLDWQSIAEELGTRRTAFQCLQKYQQHSPALKRREWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 519)

LTRLVQAM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGLWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNSKEVKKLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMVRQRQRAR---------RRARWSPSSGSSS---------
------DSSWEGSEPEEAPKDVPEEAPAGGP--------EPPPAQYAVPDMDLWVPARQS
TEEL-GGAVAGGCPRPP-----------EGPDTAQAPTPAP------------A--GQLA
SRSRSA-DLRS--VGCPCP----------AAAHR--------------------------
---------------------------------------------WTEPSPHPRGLSLPK
QERLRQLHPPGSAPGLSPGGGS-RDEARARVQPQWARTMQ-------R--RQGHALQRRL
LEHKLLTAVSPWVGEVDLLCAR--PRPAMWPRRADGI--RRQLQG---AHLASTPVF---
----------ALLIQLFQIDMPGCVEVVRERKTWPPALLQAGAWDPPPLQVRTE-TCL--
PSSPGCLTQSVPAQGAAKQSTCPEGVRGLQA-------------CHA------ASTPQVP
APAPCRPRPKPKTVSELLREKRLR-----EARA-RRAVQGPAVLS-----ARVLVSAPVV
LQPLAP-----------PGTSV----SRVVLSGP--------------GGPPVTSS--SV
SGSWAPAKA-----ERG--LTLHA-------------------FALGPA-----------
---TSRAPGQVPASCPLSVLGQSQAPATSR--------------------KQGLPEAPPL
LPVAPSP----VQPVSLTPALGTP-----TVASTPLPITWVLTAQGLLPVPLQAVVSLPT
TTG-APDPTQLSVTLPPSPAETPAS-------QSCPGPPAA-------------------
--------------SIDLEPELPCRMEPL-------SESPTEVAEACGL--AGLASPEEA
LVAGEMSSPRTPSQDM------PL---AHH--LATEPP-----------SSSPPPLHGAP
GAASGPG-----------------------------EPQPLDLEEPLLPWL--GLENGPL
DLSLLSQESEAATQ-EWLRGQQGVPVP---ALGSQLAYQPPTLCSLRALSGLLLRKKDLE
HGAAVLAPDGPAG----------------TLQASLGRVRERLRNSPAYLLLRARFLAAFT
LPALLATLSPRGVPTTLSASAGPDPETDSDDFD--P--EEPELTD--S--DGEPG-----
--------------------------DPTQGAPDPSQGPARSCLDS-----PDNPDMLQT
RRLRHVRKRRRLQ-

------------------------------------------------------------
------------------------------------------MDIDAEREKVTQEIQELE
RILYPGSSSVHFEVSESSLSS---DSEADP-LPDEDLETA--GAPV---L-EEERSSEGS
ND-DEDPKDKALPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNQEQQEEILFDLAGTKC
PKVKDAKSLPSYMYIGHFLK---PYFKDKVTGVGPPANEETREKAAQGIKAFEQLLVTKW
KHWEKDLLRKSVVSDRLQRLLQPKLLKLEYLQEKQSRVSSELEKQALEKQIKEAEKEIQD
INQLPEEALLGNRLDSHDWEKISNVNFEGARSAEEIRKFWQSSEHPSINKKE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKTIAASHGHLEWHLVAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRRI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WAPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWDAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKILARKKQHLQKR-RGQRSRHSSQWSSCSSSSSSSSSSSGSE
DYGGGSSS---SSNSSEDSEVELEEPLQNSR--------ALAPQQYSVPDIDLWVPTRLI
DSRS-QREET----GC-YPVHPAVSCRT------QNHHKEGSTVVSAPER----NQMQEC
CETHST-VP------------------------------------RGVQSLHS--SDTHG
ASV---KEPACKSHT-------------------------------------------LV
KERRRQPPLPNSRSGSDPGNS--MAG--PHLRRLWHGTFQN----KQR--RKRQALHRRL
LKHRLLLAVIPWVGDINLACTQAVQRPAAVQTQADSI--RMQLEC---ARLASTPVF---
----------TLFIQLLQIDTAGCMEVVQERKTQPPALLQPGTRNTQPHLLQAS-SNAKN
--NTGCLLPGML-DEQTAKRTSQKGRPRLG-------------SCKAEAT---P--FQVP
VAAPRGLRPKPKTVSELLREKRLR-----ESHA-KKATQALTALS-----SQLLVSSPVL
LQPPLLPAA--RGSP-VVGPA----ASSVELSVPV--------------APVMVSS--SP
SGSWQVGGI-SATDKQP--PNL--Q-TI------PLNPSHKG-TQI-AAPAA----F---
-RSLALASGHVSTGCPLNTLGQT--STTSQ--------------------KQSLPKVLPI
LPAAPSLTQLSVQP--------PPASGQPPATKSSLPVSWVLTTQKLLSVQVPAVVGLPQ
PVT-TPET----------------------------------------------------
----IGLQA-------KQL--P--------------------------------------
-------SPSKTPAF--------L---GQP--PASTDT----------------------
-----------------------------EPKGPQ--------GQQTPPT--PGPEKKAL
DLSLLSQESEAAIL-TWLTGSQGACVP---PLGSRMSYHPPSLCSLRALSSLLLHKKDLE
QKASSLVAGQAAGAQP--------EPKAGALQASLELVQRQFQNNPAYLLLKTRFLAIFS
LPAFLATLPPNSVPTTLSPAMAVGSESDSED------FGDLEPRD--G--ATQLDCMACR
VRANLMAPDP--VQSHLPSW--------FQRAPSPSAVSAPSHLDASDD--LDDLDVLRT
RHARHSRK------

------------------------------------------------------------
------------------------------------------MDADAEREKIAQEIRELE
RILDPSSSDISLVLSESSLDS---DSDAGS-LCGEDSD--SPGPLV---S-EEERWGEAG
N--EEDPKDRTLPEDPETCLQLNMVYQEVVQEKIAEINLLLAQNREQQDEITWDLAGSKG
PRAESRKSLPPYMYLGHFMK---PYFKDRVTGVGPPANEDMR------VKSFEDLLVTKW
KSREKTLLRKSVMSDRLQRLLQPKLLKLEYLQQKQSRVSSDAERQLLAKQLREAEKEIED
IHQLPEEALLGDRLDS

PF00249 // ENSGT00390000001038_0_Domain_1 (377, 404)

HDWEKISNVNFEGGRSAEEIRKFWQNW

ENSGT00390000001038_0_Linker_1_2 (404, 410)

EHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KREWSGDEVER
LKAISAQHGHLEWQKIAEELGTQRSAFQCLQQFQQHNTELKRREWTEEEDGMLTQLVREM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGYWAPEEDAKLLQAVAKHGAQ
DWFKIREEVPGESDAQ---CRD-RYVRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWNPKEEEKLIELIEKYGAGHWAK
IAAELPHRTGSQCLS-KWKIMLGKKQSRQQR--RRRPRRCVRWSSSSSGGEDNGDC----
-N--------SSNRRNSREEQGPRGADGG-----------SSRAQYVVPGVHLWVPSRQH
TMAP-WNGGARGWPGRPPATR----SPPKAAEASCVG-SEEAPA-----T--ASAPRVDA
SN--GA-PLRR-----------------------------------------VPLETV-L
QLL---RANTAARARELX---------------------------------------XXX
XXXXXXXXXXXXXXXXXXXXXX-XXX----XXXXXXXXX-X----XXX--XXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXDNI--WRQLKN---AHLSSTPVF---
----------TLLIQLFQIDTDGCMEVIRERKTQPPXXXXXXXXXXGSFPAT--------
-------------QKAERRGTGHKGSRGLAP-------------SRP-----KPPLPPAP
SPVPSGPRPKPKTVSELLQEKRQR-----EARA-RRTTLGARTLP-----VQLLVSPGA-
PLPALQ--QAPQGPP-AAGQAV----CNVVLPGL--------------GAPTGIVP--GT
AGPWPGAQN-PAKERPC---VLPA-------------------PAPTPA--GARNSAPQA
SRSLVLGP-----ACASSGLGRSQALQVSR--------------------KRGPPELPPL
LPAAPSPAPLPAFSLVPA----------HVTASAPLPVTWVLTAPGLLPVSVPTVVGLPT
PAG-SSPGLSGTL--LLSLAEAPAGQCARASXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXRVSSSLGAAR----GARETAV----PRPTETSPQSPL-----------
-----LSSP----REA------GP---AAH--PPASPQ-------------SLWPG--E-
---SQQGPRHP---------SGTEGE------------------KSHSSQP--APKKGTL
DMSLLSPEGTMDMQ-AWLRGQHGVCVP---PLGSRLPYQPPTLSTLRALSNLLLHKEALE
HKAATLVPGGATGGKQ--------GCPAGALQAALQTVHTQLGDNPAYLLLRARFLAAFS
LPALLATLPPQGVSTTLSATTRSYAES--DSED--L--EEMEPP--NR--EQLQ------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSNELEKQALEKQAREAKKEIQD
INQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQEWSGEEVEQ
LQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQRNKALKRKEWTEEEDRMLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 566)

KGNWAPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RY

ENSGT00390000001038_0_Linker_4_5 (566, 575)

LRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 618)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSSSSSSSGSGGSGR
GSS------SSSEEE--EPEPEQAQTGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHAASL----SHPKGSSASQGGSKEASTTAAAPGE--ETSAAQVP
ARAHSP-VPRA--AQASHS----------ADTQPV--GAEKQALEGGR--LTVPMETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQLPLPTSSPGVSS-GDS-VAR--SHMQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQAP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REAARGPVVLP-----SHLLVSSPVI
LQPPLP--HTPHGRP-ALGPTV----SNVPLSGP--------------GTPTAAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSQVSVSCPGSGLGQSQAPNASR--------------------KQSLPEASPF
LPAAPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPGAPALSSSWQPPA-------------------
--------------NVNSGPQPSCRTVPPAPATHAASQSPAEVDDSVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--HEAEPP-----------LPRRLPPLGGV
IPASEPGGTLGSPSETQEPKG-LDLEKPSLPQPGP--------------------EKGAL
DLGLLSQEGEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPTGALQASLGLVRGQLRDNPAYLLLRARFLATFT
LPALLATLAPHGIRTTLSAASIAGSESDDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------CHIQGPPDSGRCSASSCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREK-TQEIQALE
RILGPGPAGFDEEVSESSLESDSEAGDADS-LPDEDSA--TAGPPV---S-EGERWDGAS
ND-EDDPKGKTLPEDPETCLQLNMVYQLVLQEKLAEVSLLLAQNQEQQEEVMWDLAGSKG
PRLKDSKSLPLNLYVGHFLK---PYFKDKVTGVGPPANEDAREKAGQGIKTFEELLVTKW
KSWEKALLRKAVVSGRLQRLLQPKLLKLEYLQQKLSKATSEAEREALEKQSSKAEEEIRD
INQLPEEALLGSRLDS

PF00249 // ENSGT00390000001038_0_Domain_1 (377, 404)

HDWEKISNVNFEGGRSAEEIRKFWQNW

ENSGT00390000001038_0_Linker_1_2 (404, 410)

EHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQEWTRPELEQ
LKAIAAKHGHLHWQEIAEELGTRRSAFQCLQQFQQHNKALRRRAWTEAEDRMLTQLVQEM
RVGNHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPRLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 564)

KGLWTPEEDTKLLQAVAKYGEH
DWFKIREEVPGRSDAQ---CRD-R------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------------G
EDSSDDDLESSLLEDPETCLQMNYVYQEVIQEKIEEVELLIAQNKEQQKEILCELDGRKT
AKTGDGRNLPSNIFLGHFMK---PYFKDKTTGIGPPSNEDAKEKAAQGIKSFEQLLSTKW
KSKEKVLLQKSVVSDRLQRLLQPKLLKLSYSNQKLENVKTEMEKQILEKQIKEVEREIEA
INQLPESDLLGDKFDEHDWEKISNIHFDGRRSSEELKKFWQNWEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KNEWTEEETER
LKDIAAKHGYLDWQTVAQELGTNRTAFQCLQKYQAC

ENSGT00390000001038_0_Linker_2_3 (457, 462)

NKDLK

PF00249 // ENSGT00390000001038_0_Domain_3 (462, 513)

RKEWTRDEDKMLLELVQEM
RVGSHIPYKKI--AYYMEGRDSAQLIYRWTKS

ENSGT00390000001038_0_Linker_3_4 (513, 519)

VDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGPWTPEEDAMLLAAVEKYGER
DWYKIRTEVPGRSDAQ---CSD-RYLKA

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHRDVK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGKWSLKEEEQLIDLVQKHGLGHWSK
IAAELPHRTRSQCLS-KWKIMIGSKVLYRT----LLCHSPTSLTKKKRSRS----VKRHH
---REESSSCSESSSEDDVELDLSDTSEEEK---T------SKEECTFPSIDLWIPTQTD
VLES-CQGRHQNSSPFSFGSANARTSSSKIPNARREGGEEGVTN-KATELSTILRGLARP
HSTDIT-VKNPIEEINKKLPG-----------------GAFAAVKCGKQVLRVTLEDV-R
RVL---RENTCFQRK-------------------------------------------L-
QS---KLMSSAATLTKTSGVG--ASA--AEKHRGLWNTVGK----TRC--QERARWRKMN
LDRKLLMAVTPWVGDVLLPCTLRTGKMTFDQTKAYSI--QQKLKS---VSLSSTPLF---
----------TLFIQLFRIDTNGCMKIIRERRADAVRPQQVYGRLPKTQSLLQT-S--LK
--QCTHNNTVLNFPISYAGDASQRA-------------------PKRQTA--PPVLPSFP
APLAQAQRQKPKTVSELLREKRQM-----EKQLKEKAMQTKVFVA-----PQMMLSGPLI
IQHPPQQMI--PSAQSA------------------------------STPVVLENH--SP
PGSKVGESP-GSSQETK--V----QSNKELNEQAPQNTPERGGFPS-LNP-AAAGKA---
-PDQGGCNGQILAGSSAPVVLQNQAFVPHR--------DSGNN-------KLSLPTPVTY
---GLNHPG----PVNLLPALLAPQPGSHLTPDSVLPLTWIVTQQALLSSAVQAVVGVPQ
-G-------LQAAV-MRSQSQASLTSSGNVCGLGVPPVSSGVNTPHPSHAETKTNPQL-A
SGSPAGRTASVS-HSASVF--PVSSANPVCSISGVSSATSARSDSS---------SKTAD
SSAAQNALPGGAPTPH--AQLLPQ---MQL--PA--STQG---SDSHWN-----------
----SEGSADQ----ASK-------YRPIASKPPPAQ---AASAPPQPTT--SSAEKTLL
DYSLISLEDEELVK-EWLSGKQGVQVP---PLQTRLPYFPPFLCNLKTLSKLLLQKAALE
KQAARLLSPEGSQTEG----------EVD-LNAITELVHEKLGDDPAFLLLKARFLAAFT
LPAVLASLPPPKVVTTLSASRREYGESDEEEW-----QSEEEASE---------------
------------------------------------------------------------
--------------

------------------------------------------------------------
------------------------------------------MDIDAEREKITQEIQELE
RILYPGSSSVHLEVSESSLSS---DSEADL-LPDEDLEA-T-GTPI---V-EEERWSEAS
ND-EEDPKDKALPEDPETCLQLNMVYQEVIQEKLAEVSQLLAQNQEQQEEILYDLSGTKC
SKVKDGKSLPSYMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKSVVSDRLQRLLQPKMLKLEYLHEKQTRVSSDLERQALEKQIKEAEKEIQD
INQLPEEALLGNRLDNHDWEKISNINFEGGRSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEVER
LKAIAATHSHLEWHLVAEELGTSRSAFQCLQKFQQYNKALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 522)

LTQLVQEM
RVGNHIPYRKI--VYFMEGRDSMQLIYRWTKSLDPSLKRGF

PF13921 // ENSGT00390000001038_0_Domain_4 (522, 586)

WTPEEDAKLLQAVAKYGAQ
DWFKIREEVPGRSDAQ---CRD-RYIRRLHFSLKKGRWNAKEEQQLIQLIEKYGVGHWAR
IASELPHRSGSQCLS-KWKIMARKQQHLQRR-RGRRPNRSSQWSSSSSSDS-----EGYG
SSN----SSSSSSSSSEDSELELEEPLENGR--------ALVPQQYRVPDIDLWVPTRLI
TSQS-QREGA----GC-YPAHRAAS-CTLDTT--QSHHKEGPTTVSTPQI----SQHVV-
--------K------------------------------------VPLE-------KMLK
LIR---ARPATQNHT-------------------------------------------LV
KERLRQPSLPNSHSESDPGDN--VAV--PHLRRLWHGTFQN----KLR--RKRQALHRRL
LKHRLLLAVIPWVGDINLSCTQAPRRPAIVQTQADSI--RTQLER---AHLTSTPVF---
----------TLLIQLLQIDAVGCMEVVRERKAQPPAVLQPSTQNPQPHLLQAF-SSAKN
--STGCLLPSMP-GQQTTKRDSHKGRPRLG-------------TCGTEAT---S--FQVP
VAAPGGLRPKPKTVSELLREKRLR-----ESRA-KKATQALTAIN-----SQLLISSPVI
LQPPLLPAL--QGSP-VAGPA----TSSVELSVPV--------------APVMVSS--SP
SGSWQVTGM-SATDKQP--PIQ--Q-TI------PLNASHKG-TQI-AAPAA----F---
-RSLALAPRQVPTGCPLSTLGQSQASVTSQ--------------------KQGLSKVLPL
LPASPSPTQLPVQPLSLPPVLGSQASGQPQAAKASLPINWVLTTQKLLSVPVPA-VSLPQ
SVM-TPDT----------------------------------------------------
----IGPPA-------KQL--P--------------------------------------
-------SPATTPAC--------L---GQL--PASTDT----------------------
-----------------------------EPKGPQ--------GQEIPTI--SGPEKKAL
DLSLLSQESETATL-TWLKGCQGACVP---PLGSRMPYQPPSLCSLRALSSLLLHKKDLE
QKASSLVTSQAAGSQS--------EPKAEALQTSLGLVQRQLQDNPAYLLLKTRFLALFS
LPALLATLPPNSVPTTLSPAVAVGSESDSEDL-----LGDLELKD--R--ARQLDCLACR
IQASPAATDP------------------EQRAPGPGED-----LDASD-----DLDVLRT
RHARHSRKRRLL--

------------------------------------------------------------
------------------------------------------MDVDAEREKIAKEIAELE
RILDPSSSGIGVGVSESGLTL---DSDGDS-LPEEDSE--AAGSPG---S-EEERWGEAS
NG-EDNPKEKTLPEDPETCLQLNMVYQEVIQERLAEVSLLLAQNREQQEEIMCDLAGSKG
PKVKDGKSLPPNLYIGHFMK---PYFKDRVTGVGPPANEETREKAAQGIKAFEELLVTKW
KNWEKALLRRSVVSDRLQRLLQPKLLKLEYLDQKRSKVTSEAERQMLEKQSREAEREVQD
IRQLPEEALLGSRLDSHDWEKISNVNFEGGRSAEEIRKFWQNCEHPSIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 457)

KQEWSGQEVDQ
LKAIAAKHGHLQWQKIAKELGTNRSAFQCLQKYQQHNKALKRKEWTREEDRLLTQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPGLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 569)

KGYWAPEEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYLRR

ENSGT00390000001038_0_Linker_4_5 (569, 575)

LHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 622)

KGRWNASEEGKLLELIEKYGVGHWAK
IASELPHRTGSQCLS-KWKVMVRKKQNRGRR--RRRPLRSVRWSSSSGDSSSGXXXXXXX
S---------SDSEDS--EPEEAPEARAGGQ--------ALPSAPHAVPDMDLWVPARQS
TGEP-CGGGSRGWPGRRAASP----GPPRGSSEAQDGSRATHPTASAPAE--EAGQADTS
SRIHST-SARG--VGHLDS----------ADT----------------------------
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------------------------------------------------------------
------------------------------------------MDIDAEREKITKEIKELE
RILDPSSSSIHLEVSESSLDSS--GSEADS-LPNEDSD--TTGAPV---L-EGERWGEAS
ND-EEDHKDKTLPEDPETCLQLNMVYQEVIREKLAEVSQLLAQNREQQEEILWDLAGSKG
LKMKEGRSLPPNMYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEALLVTKW
KHWEKALLRKSVVSDRLQRLLQPKLLKLEYLRQKQSRVSSEPERQALEKQVREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNVNFEGGRSAEEIQKFWQSSEHPSINKQD

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSTEEADR
LRAIAAKHGHLEWQQVAEELGTGRSAFQCLQKFQQHNTALKRKEWTEEEDHM

ENSGT00390000001038_0_Linker_2_4 (473, 520)

LTQLVQEM
RVGDHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLKK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWTPEEDAKLLQAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNAKEEEQLIELIEKYGVGHWAK
IASELPHRSGSQCLS-KWKIMRNQS-LPRRR--RRRPRRRVHWSSSSSSDSGSEDSADA-
SSS---SSSSSSSSSSESSEAELEEPQGQAR--------VLLPPQYTVPDLDLWVPARQS
ASQP-QKGGASSS-------------LPKGSDAAPSRPKEVP--T-------SAPGGKPP
SRIQGT-IPRG--VQYPHP----------PDTHPV--NVEEPAFEP--------------
-----------------F---------------------------------------SLQ
KERQRQPVLPDSPPGPGP-GDG-VTG--PHLKRLWR-----------Q--RQRHTLRQRL
LDRKLLLAVTPWVGDVTLPCTQASRRPGAVQTHADRV--RMKLEH---AHLASTPVF---
----------TLFIQVKWVA--GAWPLVRPRTRALY---S------TDTTYRLP-LGVSP
--STGRPFPNAPPQGTAQ-NTSHVGYRGLGS-------------CHT-----ESASSQVP
APAPCGPRPKPKTVSELLREKRLR-----ESRA-KKAAQAPVALQ-----PQLLVSSPVV
LQPSLP--PASQGLP-APCLTI----TNPTLSGP--------------GSPVLASA--SP
SGSWQEAGA-SAKDERP--AGLQA-------------------VTLTPVLPGAQGTASSA
CSLPALGLSQGPVSCPPSSLGQPQAPATSQ--------------------EQSLPRVLPL
FPTTPSPAQLPLQPLRGS-----------PLASLPLPVTWVLTAQGLLPVPVQAMVGVSG
QVA-TPDPAGLPATLPPPPAETPCLSPA--------------------------------
--------------SADPEPVPS-------------------------------------
------------------------------------------------------------
----------------------SMTL------------------PPSRNSS--GPEKGAW
DLGLLSQENEAALR-KWLKGQQGAHVP---RLESRLPYQPPALCNLRVLSSLLLHKKALE
QKAASLLAGT--------------EPEAGATQSSLGLVRRRLRDNPAYLLLKTRFLAAFA
LPAFLATLPPCGVPTTLSLAPRVDTESEDD-------LGELDCK--DM--SSVVQVG---
---------------------------PLPLSRGPHGASAPSQL-----DTSDDLRVLRT
RHAQHARK------

------------------------------------------------------------
------------------------------------------MDIDAEREKISKEIKELE
RILDPSSSSIPVDISESSLDS---DSDAES-LPAEDLD--IAGPPV---L-VEERWGGGS
ND-EEDPKEKALPEDPETCLQLNMVYQEVIQEKLAEVSLLLAQNREQQEEILWGLSGSQG
PRVKDSKGLLPHMYIGHFMK---PYFKDKVTGMGPPANEDTREKAAQGIKAFEQLLVTKW
KHWEKALLRKAVVSDRLQRLLQPKLLKLEYLRQKQSRVSSEPERQALEEQARCAEQEIQD
INQLPEEALLGNRMDSHDWEKISKVNFEGSRSAEEIQKFWQSSEHPSINKQE

PF13921 // ENSGT00390000001038_0_Domain_2 (413, 473)

WSMEEVER
LTAVATAHGHLQWQLVAKELGTGRSAFQCLQKFQQHNKALKRREWTEEEDRM

ENSGT00390000001038_0_Linker_2_4 (473, 520)

LTQLVQQM
RVGSHVPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLKK

PF00249 // ENSGT00390000001038_0_Domain_4 (520, 567)

GFWAPDEDAKLLRAVAKYGEQ
DWFKIREEVPGRSDAQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

RRLHASLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWTAQEEEQLLGLIEKHGVGHWAK
IASELPNRSGSQCLS-KWKIMAGKKQRVQRRRRQRRPRPRVRWSSSSSSSGDSDSGGSGS
S-------SSSSSSSSKDSEVELEEPPQAGS--------MPPSPQYTVPDMDLWVPVRHS
ATQR----------------------------------PEASRTALAPGE--ERRQVQAS
SEVLGT-----------HS----------AGTQHT--NLEEPAHKVGRGTLHIGGHSA-P
PC-------PAV--HTPV---------------------------------------FCP
QERLRQPPRPSLPPGPGP-GDS-EAG--AHLRQLWRGTFQN----RHQ--RRRRILHRRL
LERRLLLAVAPWVGDVNLPCTLAPQRPAVTKTRADGV--RTQLER---VHLASTPVF---
----------TLCMQLLQIDTAGCMEVVRERKAQLP---PPGPQHPLPRPLASS-VG---
-----CHSQQRQ------------------Q-------------SWVGPGSRGHEAVTQE
RAACRGPRPRPKTVSQLLREKRLH-----KAPT-RKATLGPVSLT-----PQL-LISPVV
LQQPLT--SACQGPP-VVGPAF----TSTGLPRP--------------VTPTATVT--SA
SGSQQEVGT-SGKDKDQ--CL-----------------------PM----------SQVP
QLAPTLGPGQAPAGCPPSSLGQSQAPTTTR--------------------RQGLPEVPTC
LPAAPSPAQPHIQPLSLTPAL---------ATSIPLPITWVLTAQGLLPVQVPAVLGLPT
PGE-VLQPPKTPALAPPTPSG----------PPTSPCQPPA-------------------
--------------NM--------------------------------------------
------------------------------------------------------------
---------TV-------PSGPLG------------------LE--RPLLP--GLEKRAL
DLGLLCLESEVVTQEQWLRGQRGVCVP---PLETRLPYQPPALCSLRALSSLLLHRAALE
HKAASLAVDRAVG--------------PVAWRTSLELVRRQLQDNPAYLLLKARFLALFT
LPALLATLPPDGVPTTLSAVLSTGLESTDE--D--L--SELESGDGDG--NEQLGCTAPR
IQARPMPMSP-----------------MQVRTPDSGEG-AVSCLDA-----SDDLDVLRT
RHGRHNRK------

------------------------------------------------------------
---------------------------------------MSPVDLQAEREKIRQEIEELE
KSLDPGIPSIEVLVSDSSLDS---DSDIGD-LDDDD-------SDA---H-TEMEVEKGG
GSGNDDDIDNNLPADPETCLQMNLVYQEVIQEKIEEVNLLIAQNKEQQKELMCEV-GPKT
AKAGDGRSLPLNLFLGHFMK---PYFKDKASGIGPPANEDTREKTAQGIKSFEELLVKKW
KSREKILLSKSVVSDRLQRLLQPKLLKLSYLNQKLEKAKNEMEKQILAKQIKEAEREIEE
INHLSEEALLGNRQDEHDWEKISNINFDGSRNAEELRKFWQNWEHPTIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

KEEWNEEEIEK
LKEVAAKHEHLHWQTIAQELGTNRSAFQCLQKFQAYNKDFKRKEWTKEEDQMLLQLVQEM
RVGSHIPYKKI--AYYMEGRDSMQLIYRWTKSVDPSLR

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 567)

KGFWTLEEDEQLLAAVAKYGER
DWYKIRAEVPGRSDTQ---CRD-RYL

ENSGT00390000001038_0_Linker_4_5 (567, 575)

NALHHDVK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGKWSLEEEEKLIELVEKYGVGHWTK
IASELLHRTGSQCLS-KWKFMIGTKKRSRPR-K----------------RL----QKRRR
---VQRPGFSSSESSSEESEPELMDSSEEEIDP-P------SGFNNLVPGLDLWIPTRTD
PNAH-RKAKRLIPSLYHFKNTHVTGCLSQVPKASAGGGQDQVPA-DSAGLNTVLKGIGFP
SSTDVN-LKDPEEL-------------------------VKEASMRGKQVLKVTLEDV-R
RAL---RNNTYSQRR-------------------------------------------R-
QNGLQKPCTPSS----AVASD--TSV--MQVLQELKNIRKK----QHR--CQRKQSRRKN
LARRLLMAVTPWVGNVLLPCTRAG----SHQTKADVV--REQLQT---VTLASTPVF---
----------TLFIQLFQIDTSGCMKVIRERRLKQSELIKTMAGNARMLQQP--------
--SCDFLKSSGQPAQPLPQK-----VGAKAAWKPITVKAKEK-----------PAAVPAA
VPALPAPRQKLKTVSELLREKRLR-----ESRA-KKALQRTVILA-----PQVLVSPSVI
IQHPVQPVI--PATQGGSGPQTAGFAASLAS------------------PSSGMSR--SS
PAPESGAGA-CPSQGN---A----NSKRKLEEAASE------GLASQDRPVSVGEKG---
-LSQGGRKAQVFGGSSAHIVLQNQGFMPHQIALMPSSAISLSPVPVKSDPTETSPSTSPC
---APALVRSQPNAINLLPAVVAPQTGSRI-----VPITWVMTPQGLIPTSVQALVGAHS
QGK-QPTAGIGGSA-TKNLSQTRETSNANTSAPNMPPTPAQASPLPVRC-----------
----LGTQVLSSQSAPSTLPPSATSSDPGCNSPSTAPSASASLHGL---------SQTSD
SSGKRNVAPTSLPSGP--GESSNS---GRL--TGTSSSPGVLVKESLVQRPDRLLACKNV
VT-NSNTPGAQ----VTR-------HRPIFPKPLSAS---HVASPPALPA--PSAEKNLL
DVSLISLEDEASVK-EWLRGKRGIQVP---ALKTGLSYLPPFLCNLKTLSRLLLQKAALE
QSVSCLGTFAECGDGD----------AGTDLPAVRELVRQKLSXX---------XXXXXT
LPAALATLPPPRVTTTLSRSWQQSSESEEEES-----LTDKELSE--A--GSCGKEPGEV
SFDGTAAIVPGSKDSAVTNQGAGAEVSAVQSVPGSCPD-------------VGGTRVQQT
RRSARLRKKRRT--

------------------------------------------------------------
------------------------------------------MDVDAEREKITQEIKELE
RILDPSSAGTHVEVSESSLES---DSEAES-LPSEDLD--PADPLI---S-EEERWGEAS
ND-EDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKG
TKVKDGRSLPPSTYMGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKW
KNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSEMEKQALEKQAREAEKEIQD
INQLPEEALLGNRLDSHDWEKISNIN----------------------------------
---------------------TSRSAFQCLQKFQQRNKALKRKEWTEEE-----------
------------------------------------------------------------
-----------------------DYLRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 619)

KGRWNLKEEEQLIELIGKYGVGHWAK
IASELPHRSGSQCLS-KWKIMMGKKQGLRRR--RRRARHSIRWSSSSS-SSSSGSGGSGR
GSS------SSSEEE--EPEPEQAQAGEGDR--------ALLSPQYVVPDMDLWVPARQS
TSQPWRGG-AGAWLGGHAASL----SPPKGSSASQGGSKEASATAAAPGE--ETSAVQAR
ATAHSP-VPRA--AQASHS----------ADTHPV--GAEKQALEGGR--LTVPVETV-L
RVL---RANTAARSR-------------------------------------------TQ
KEQLRQPPLPTSSPGVSS-GDS-VAR--SHVQWLRHRATQS----GQR--RWRHALHRRL
LNRRLLLAVTPWVGDVVLPCTQVPQRPAAVQTQADGL--REQLQQ---ARLASTPVF---
----------TLFTQLFQIDTAGCLEVVRERKALPPRLPQAGARDPPMHLLQAP-SSAQS
--TPGHLFPNVPAQEASK-SASHKGSRRLAS-------------SQV-----EGTLPQAS
PLAPTGPRPKPKTVSELLQEKRLQEKRLQEARA-REATQGPVVLP-----SHLLV-SPVI
LQPPLP--HTPHSHP-ALGPTV----SNVPYSGP--------------GTPAEAKP--GT
SGSWQEAGP-SAKDKRL--STMQA-------------------LPLAPAFTGPEGTAPAA
SGAPGLGPSQVSVSCPGSGLGQSQAPTASR--------------------KQSLPEASPF
LPAAPSPTPLPIQPLSLT-----HVGGPRVAASVPLPVTWVLTAQGLLPVPVPAVVGLSS
PAG-TPGPTGLVATLLPPLTEAQAAQGPGAPALSSSWQPPA-------------------
--------------NVNSGPEPSCGTVPPAPPTHAASRSPAEVDASVAV------VPGEA
QVAREIPAP----RTS------SQ---ADP--PEAEPP-----------LPRRLPPLGGV
IPASEPGGTLGSPSGTQEPKGTLDLEKPPLPQPGP--------------------EKGAL
DLGLLSQEAEAATQ-QWLGGQRGVRVR---LLGSRLPYQPPALCSLRALSSLLLHKKALE
HKAASLVAGG----EA--------ERPAGALQASLGLVRGQLRDNAAYLLLRARFLAAFT
LPALLATLAPHGVRTTLSAVSIAGSESEDEDL-----LSELELA--DR--DGQPGCTAAT
--------------------------RHIQGPPDSGRCSAASCLDAFNDLDVDDLDVLRT
RHARHTRKRRRLV-

------------------------------------------------------------
------------------------------------------MDVDAEREKIAKEIEELE
RILDPSSLSINGEVSESSLES---DSEADS-LLDEDSD--PPGPPA---L-EGGRWGDAS
NE-EDDTKDRNLPEDPETCLQLNMVYQEVIREKIAEVSVLLAQNREQQEEITWDLAGAKG
PKAKGGKGLPANVYIGHFMK---PYFKDKVTGVGPPANEDTREKAAQGIKSFEQLLVTKW
KNWEKTLLRKSVMSDRLQRLLQPKLLKLEYLQQKQSKAASEPERQALEKQIREAGKDIQE
INQLPEEALLGNRQDSHDWEKISNVNFEGGRSAEEIRKFWQNCEHPSINKQEWSREEIAL
LKEVSARHGHLGWQQTAEELGTGRSAFQCLQKFQQHNKGLKRREWTEEEDRLLSQLVQEM
RVGSHIPYRRI--VYYMEGRDSMQLIYRWTKSLDPSLK

PF00249 // ENSGT00390000001038_0_Domain_4 (519, 565)

KGCWAPEEDAKLLQAVAKYGEH
DWFKIRAEVPGRSDAQ---CRD-R

ENSGT00390000001038_0_Linker_4_5 (565, 575)

YVRRLHFSLK

PF00249 // ENSGT00390000001038_0_Domain_5 (575, 620)

KGRWNSKEEEKLIELIEKHGVGHWAK
IASELPHRTGSQCLS-KWKVLAGKRQSQQRR--RRRPQRSARWSSSSSSGGSGGS--GGS
GES---SSSSSSEDLGAELEEGPGV-PGQGG--------ALPPAAYVVPSMDLWVPARQG
AREL-WVGRSAS-------SA----LPPKAAPG----------SALAPGE--DAGLAQAP
SRACSA-VLRG--PRDPRS----------PDVHPA--RSEELEDEDGRRPPEVPLETV-L
QVL---RTNTAAWRR-------------------------------------------RL
KEKLRPSHLPSAALASGADGSS--AG--PHLLRSRPPRILR----RHR--RQRHALRRRL
LDRRLLMAMSPWVGDVSLPQAPASRRTAMAQTRGTAL--GAGQEGGPGKAVAASPET---
----------PCFLQLFQIDTEGCMEVIRERRAQPPAALQAGCRDP-ALPLQVP-SSAQH
--TPGCVLR-VPAREAAKKGASRKGGGGLGP-------------A-------AEAAPRAP
LTAPAGPRPKPKTVSELLREKRLR-----EARA-RKATAGAVVLA-----PPVLLSSPLI
LPAPLL--AAPQGPP-ATGL-----------PGP--------------VSPTPAHP--SS
ASSSQEAET-PAKEGSP--PAPPA-------------------LAPTK------ASAPST
SRDTAVGPE----SRGPDRTGHCQAPTAPR--------------------KQGLPEAPAL
LPAAPSPRQLPVQPLRLVQALGQHRGAALVTAPAPLPVTWVLTAQGLLPVSGPAIGGPPR
PEQ-PAGAPRV----GP-------SACA---RTPCPREPPA-------------------
----------------DLVPVPPSKT--------DPADSPTEVDRDAAS------APGGP
SPPREATAPPPQPSTP------SQ---ARP--PDGRPV-----------EPP--------
------------------------------------------------------------
-------LHSGAGR-TWSSGRGPGRAR---------------------------------
--GGGQPRGGAAG--------------------RTRPGAGALRDSTAYLLLQARFLAAFT
LPALLATLPPRGVPTTLSAASGDPG-S--EDED--S-PGELEAP--NG--AARQRGPPSG
----------A----------GSPALPGVQGALDAGAGFAATCLE----A-SDDLDVLQT
RRSRHARKRRRLE-

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---LPEEYLLANRFEEHDWEKIANVNFDGTRSAKELQRFWQNSEHPDIN

PF00249 // ENSGT00390000001038_0_Domain_2 (410, 456)

RKEWSPEETEA
LKEIATRRNGFDWAAIAQELGTQRTAFQCLQKFQT

ENSGT00390000001038_0_Linker_2_3 (456, 463)

YNKDLKK

PF00249 // ENSGT00390000001038_0_Domain_3 (463, 511)

REWTPEEDQMLLQMVREM
RVGKHIPYRKI--AYYMEGRDPAQLIYRWTKRVDPKLKHGPWTPKEDA------------
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